Oxytocin Is a Nonapeptide Involved in a Wide Range of Physiologic OXT Activity Depends on Adequate Interaction with Its Unique and Behavioral Functions
Evolutionary pattern in the OXT-OXTR system in primates: Coevolution and positive selection footprints Pedro Vargas-Pinillaa,1, Vanessa Rodrigues Paixão-Côrtesa,1, Pamela Paréa, Luciana Tovo-Rodriguesa, Carlos Meton de Alencar Gadelha Vieiraa, Agatha Xaviera, David Comasb, Alcides Pissinattic, Marialva Sinigagliaa, Maurício Menegatti Rigoa, Gustavo Fioravanti Vieiraa, Aldo B. Luciond, Francisco Mauro Salzanoa,2, and Maria Cátira Bortolinia,2 aDepartamento de Genética, Instituto de Biociências, Universidade Federal do Rio Grande do Sul, 91501-970 Porto Alegre, RS, Brazil; bInstitut de Biologia Evolutiva, Departament de Ciències Experimentals i de la Salut, Universitat Pompeu Fabra, 08003 Barcelona, Spain; cCentro de Primatologia do Rio de Janeiro, 20940-200 Rio de Janeiro, RJ, Brazil; and dDepartamento de Fisiologia, Instituto de Ciências Básicas da Saúde, Universidade Federal do Rio Grande do Sul, 90050-170 Porto Alegre, RS, Brazil Contributed by Francisco Mauro Salzano, November 26, 2014 (sent for review July 11, 2014; reviewed by Guido Barbujani and Rafal Slusarz) Oxytocin is a nonapeptide involved in a wide range of physiologic OXT activity depends on adequate interaction with its unique and behavioral functions. Until recently, it was believed that an receptor, OXTR, although it can also bind to the vasopressin unmodified oxytocin sequence was present in all placental mam- receptors (AVPR1a, AVPR1b, and AVPR2) with lower affinity mals. This study analyzed oxytocin (OXT) in 29 primate species and (11–13). Similar to other receptors that use G proteins as OXTR the oxytocin receptor ( ) in 21 of these species. We report transducer signals across the cell membranes, OXTR is com- here three novel OXT forms in the New World monkeys, as well posed of seven transmembrane (TM1–TM7), four extracellular as a more extensive distribution of a previously described variant (N-terminal tail-ECL3), and four intracellular (ICL1-C-terminal (Leu8Pro).
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