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JMIR Research Protocols JMIR Research Protocols Ongoing Trials, Grant Proposals, Formative Research, Methods, Early Results Volume 6 (2017), Issue 8 ISSN: 1929-0748 Contents Protocols Pacing, Conventional Physical Activity and Active Video Games to Increase Physical Activity for Adults with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Protocol for a Pilot Randomized Controlled Trial (e117) Katia Ferrar, Ashleigh Smith, Kade Davison. 4 A Web-Based Public Health Intervention to Reduce Functional Impairment and Depressive Symptoms in Adults With Type 2 Diabetes (The SpringboarD Trial): Randomized Controlled Trial Protocol (e145) Judy Proudfoot, Janine Clarke, Jane Gunn, Susan Fletcher, Samineh Sanatkar, Kay Wilhelm, Lesley Campbell, Nicholas Zwar, Mark Harris, Helen Lapsley, Dusan Hadzi-Pavlovic, Helen Christensen. 16 Efficacy of Lactobacillus Reuteri DSM 17938 for the Treatment of Acute Gastroenteritis in Children: Protocol of a Randomized Controlled Trial (e164) Henryk Szyma ski, Hania Szajewska. 31 Smartphone-Enabled Health Coaching Intervention (iMOVE) to Promote Long-Term Maintenance of Physical Activity in Breast Cancer Survivors: Protocol for a Feasibility Pilot Randomized Controlled Trial (e165) Paul Ritvo, Maya Obadia, Daniel Santa Mina, Shabbir Alibhai, Catherine Sabiston, Paul Oh, Kristin Campbell, David McCready, Leslie Auger, Jennifer Jones. 38 Simulation-Based Training of Non-Technical Skills in Colonoscopy: Protocol for a Randomized Controlled Trial (e153) Rishad Khan, Michael Scaffidi, Catharine Walsh, Peter Lin, Ahmed Al-Mazroui, Barinder Chana, Ruben Kalaichandran, Woojin Lee, Teodor Grantcharov, Samir Grover. 54 Are Routine Radiographs Needed the Day After Open Reduction and Internal Fixation Surgery for Distal Radius and Ankle Fractures: Study Protocol for a Prospective, Open Label, Randomized Controlled Trial (e159) Florian Oehme, Annika Rühle, Julia Mühlhäusser, Lana Fourie, Björn-Christian Link, Reto Babst, Frank Beeres. 63 The Spanish Version of the Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Adolescents (UP-A) Adapted as a School-Based Anxiety and Depression Prevention Program: Study Protocol for a Cluster Randomized Controlled Trial (e149) Julia García-Escalera, Rosa Valiente, Paloma Chorot, Jill Ehrenreich-May, Sarah Kennedy, Bonifacio Sandín. 72 Ivermectin Treatment in Patients With Onchocerciasis-Associated Epilepsy: Protocol of a Randomized Clinical Trial (e137) Robert Colebunders, Michel Mandro, Deby Mukendi, Housseini Dolo, Patrick Suykerbuyk, Marieke Van Oijen. 90 JMIR Research Protocols 2017 | vol. 6 | iss. 8 | p.1 XSL·FO RenderX Project Stronger Together: Protocol to Test a Dyadic Intervention to Improve Engagement in HIV Care Among Sero-Discordant Male Couples in Three US Cities (e170) Rob Stephenson, Nicolas Suarez, Robert Garofalo, Marco Hidalgo, Samuel Hoehnle, Jennie Thai, Matthew Mimiaga, Emily Brown, Anna Bratcher, Taylor Wimbly, Patrick Sullivan. 98 A Mobile Device App to Reduce Medication Errors and Time to Drug Delivery During Pediatric Cardiopulmonary Resuscitation: Study Protocol of a Multicenter Randomized Controlled Crossover Trial (e167) Johan Siebert, Frederic Ehrler, Christian Lovis, Christophe Combescure, Kevin Haddad, Alain Gervaix, Sergio Manzano. 110 Medicine Goes Female: Protocol for Improving Career Options of Females and Working Conditions for Researching Physicians in Clinical Medical Research by Organizational Transformation and Participatory Design (e152) Joachim Hasebrook, Klaus Hahnenkamp, Wolfgang Buhre, Dianne de Korte-de Boer, Ankie Hamaekers, Bibiana Metelmann, Camila Metelmann, Marina Bortul, Silvia Palmisano, Jannicke Mellin-Olsen, Andrius Macas, Janusz Andres, Anna Prokop-Dorner, Tomáš Vymazal, Juergen Hinkelmann, Sibyll Rodde, Bettina Pfleiderer. 121 Combination Analgesic Development for Enhanced Clinical Efficacy (CADENCE Trial): Study Protocol for a Double-Blind, Randomized, Placebo-Controlled Crossover Trial of an Alpha-Lipoic Acid ± Pregabalin Combination for the Treatment of Fibromyalgia Pain (e154) Ian Gilron, Dongsheng Tu, Ronald Holden, Tanveer Towheed, Elizabeth Vandenkerkhof, Roumen Milev. 134 Impact of a Tutored Theoretical-Practical Training to Develop Undergraduate Students' Skills for the Detection of Caries Lesions: Study Protocol for a Multicenter Controlled Randomized Study (e155) Mariana Braga, Tathiane Lenzi, Fernanda Ferreira, Fausto Mendes, Daniela Raggio, José Imparato, Marcelo Bonecker, Ana Magalhães, Linda Wang, Daniela Rios, Juliano Pessan, Cristiane Duque, Maria Rebelo, Ary Alves Filho, Marina Lima, Marcoeli Moura, Alessandro De Carli, Mariane Sanabe, Maximiliano Cenci, Elenara Oliveira, Marcos Correa, Rachel Rocha, Julio Zenkner, Pedroza Murisí, Stefania Martignon, Juan Lara, Fatima Aquino, Alfredo Carrillo, Chun Chu, Chris Deery, David Ricketts, Paulo Melo, José Antunes, Kim Ekstrand, IuSTC Group. 145 Systematic Review Protocol to Assess the Effectiveness of Usability Questionnaires in mHealth App Studies (e151) Leming Zhou, Jie Bao, Bambang Parmanto. 153 mHealth Technologies for Palliative Care Patients at the Interface of In-Patient to Outpatient Care: Protocol of Feasibility Study Aiming to Early Predict Deterioration of Patient's Health Status (e142) Gudrun Theile, Vanessa Klaas, Gerhard Tröster, Matthias Guckenberger. 160 Ascertaining the Value of Noninvasive Measures Obtained Using Color Duplex Ultrasound and Central Aortic Pressure Monitoring During the Management of Cerebral Arteriovenous Malformation Resection: Protocol for a Prospective, Case Control Pilot Study (e173) Kathryn Busch, Hosen Kiat. 217 Feasibility of a Facebook Intervention for Exercise Motivation and Cardiac Rehabilitation Adherence: Study Protocol (e162) Lee Siegmund, Haitham Ahmed, Michael Crawford, James Bena. 230 Beliefs, Knowledge, Implementation, and Integration of Evidence-Based Practice Among Primary Health Care Providers: Protocol for a Scoping Review (e148) Filipa Pereira, Mireille Salvi, Henk Verloo. 253 JMIR Research Protocols 2017 | vol. 6 | iss. 8 | p.2 XSL·FO RenderX Proposal Automating Construction of Machine Learning Models With Clinical Big Data: Proposal Rationale and Methods (e175) Gang Luo, Bryan Stone, Michael Johnson, Peter Tarczy-Hornoch, Adam Wilcox, Sean Mooney, Xiaoming Sheng, Peter Haug, Flory Nkoy. 169 Tutorial Opening the Black Box of Electronic Health: Collecting, Analyzing, and Interpreting Log Data (e156) Floor Sieverink, Saskia Kelders, Mannes Poel, Lisette van Gemert-Pijnen. 188 Original Papers Barriers and Facilitators for the Use of a Medical Mobile App to Prevent Work-Related Risks in Pregnancy: A Qualitative Analysis (e163) Adeline Velu, Monique van Beukering, Frederieke Schaafsma, Monique Frings-Dresen, Ben Mol, Joris van der Post, Marjolein Kok. 200 An Electronic Health Record±Based Strategy to Systematically Assess Medication Use Among Primary Care Patients With Multidrug Regimens: Feasibility Study (e157) Stacy Bailey, Christine Oramasionwu, Alexandra Infanzon, Emily Pfaff, Izabela Annis, Daniel Reuland. 223 Conventional Cognitive Behavioral Therapy Facilitated by an Internet-Based Support System: Feasibility Study at a Psychiatric Outpatient Clinic (e158) Kristoffer Månsson, Hugo Klintmalm, Ragnar Nordqvist, Gerhard Andersson. 239 Correction of: Effectiveness of Adaptive E-Learning Environments on Knowledge, Competence, and Behavior in Health Professionals and Students: Protocol for a Systematic Review and Meta-Analysis (e131) Guillaume Fontaine, Sylvie Cossette, Marc-André Maheu-Cadotte, Tanya Mailhot, Marie-France Deschênes, Gabrielle Mathieu-Dupuis. 251 Short Paper Engaging Adolescents to Inform the Development of a Mobile Gaming App to Incentivize Physical Activity (e161) Lizzy Pope, Bernice Garnett, Marguerite Dibble. 211 Corrigenda and Addenda Correction of: Development of a Web-Based Intervention for Addressing Distress in Caregivers of Patients Receiving Stem Cell Transplants: Formative Evaluation With Qualitative Interviews and Focus Groups (e130) Nicole Pensak, Tanisha Joshi, Teresa Simoneau, Kristin Kilbourn, Alaina Carr, Jean Kutner, Mark Laudenslager. 249 JMIR Research Protocols 2017 | vol. 6 | iss. 8 | p.3 XSL·FO RenderX JMIR RESEARCH PROTOCOLS Ferrar et al Protocol Pacing, Conventional Physical Activity and Active Video Games to Increase Physical Activity for Adults with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome: Protocol for a Pilot Randomized Controlled Trial Katia Elizabeth Ferrar1, B.App.Sc (PT), B. Hlth. Sc (Hons), PhD; Ashleigh E Smith1, B. Sc (Biomedical Science), B.Sc (Hons), PhD; Kade Davison1, B.App.Sc(HM), B.Hlth.Sc.(Hons), PhD Alliance for Research in Exercise, Nutrition and Activity, School of Health Sciences, University of South Australia, Adelaide, Australia Corresponding Author: Katia Elizabeth Ferrar, B.App.Sc (PT), B. Hlth. Sc (Hons), PhD Alliance for Research in Exercise, Nutrition and Activity School of Health Sciences University of South Australia GPO Box 2471 CEA-14 Adelaide, Australia Phone: 61 8 8302 2554 Fax: 61 8 8302 2853 Email: [email protected] Abstract Background: Myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) is a serious illness of biological origin characterized by profound physical and cognitive exhaustion and postexertion malaise. Pacing is a common strategy used to manage available energy and complete activities of daily living; yet little research has investigated this as a strategy to increase physical activity levels. Typically, people living with ME/CFS are faced by unique barriers to physical activity
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