ATY Instructions / ૂચના
Total Page：16
File Type：pdf, Size：1020Kb
Load more
Recommended publications
-
Dermatopathology
Dermatopathology Clay Cockerell • Martin C. Mihm Jr. • Brian J. Hall Cary Chisholm • Chad Jessup • Margaret Merola With contributions from: Jerad M. Gardner • Talley Whang Dermatopathology Clinicopathological Correlations Clay Cockerell Cary Chisholm Department of Dermatology Department of Pathology and Dermatopathology University of Texas Southwestern Medical Center Central Texas Pathology Laboratory Dallas , TX Waco , TX USA USA Martin C. Mihm Jr. Chad Jessup Department of Dermatology Department of Dermatology Brigham and Women’s Hospital Tufts Medical Center Boston , MA Boston , MA USA USA Brian J. Hall Margaret Merola Department of Dermatology Department of Pathology University of Texas Southwestern Medical Center Brigham and Women’s Hospital Dallas , TX Boston , MA USA USA With contributions from: Jerad M. Gardner Talley Whang Department of Pathology and Dermatology Harvard Vanguard Medical Associates University of Arkansas for Medical Sciences Boston, MA Little Rock, AR USA USA ISBN 978-1-4471-5447-1 ISBN 978-1-4471-5448-8 (eBook) DOI 10.1007/978-1-4471-5448-8 Springer London Heidelberg New York Dordrecht Library of Congress Control Number: 2013956345 © Springer-Verlag London 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifi cally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. -
Table I. Genodermatoses with Known Gene Defects 92 Pulkkinen
92 Pulkkinen, Ringpfeil, and Uitto JAM ACAD DERMATOL JULY 2002 Table I. Genodermatoses with known gene defects Reference Disease Mutated gene* Affected protein/function No.† Epidermal fragility disorders DEB COL7A1 Type VII collagen 6 Junctional EB LAMA3, LAMB3, ␣3, 3, and ␥2 chains of laminin 5, 6 LAMC2, COL17A1 type XVII collagen EB with pyloric atresia ITGA6, ITGB4 ␣64 Integrin 6 EB with muscular dystrophy PLEC1 Plectin 6 EB simplex KRT5, KRT14 Keratins 5 and 14 46 Ectodermal dysplasia with skin fragility PKP1 Plakophilin 1 47 Hailey-Hailey disease ATP2C1 ATP-dependent calcium transporter 13 Keratinization disorders Epidermolytic hyperkeratosis KRT1, KRT10 Keratins 1 and 10 46 Ichthyosis hystrix KRT1 Keratin 1 48 Epidermolytic PPK KRT9 Keratin 9 46 Nonepidermolytic PPK KRT1, KRT16 Keratins 1 and 16 46 Ichthyosis bullosa of Siemens KRT2e Keratin 2e 46 Pachyonychia congenita, types 1 and 2 KRT6a, KRT6b, KRT16, Keratins 6a, 6b, 16, and 17 46 KRT17 White sponge naevus KRT4, KRT13 Keratins 4 and 13 46 X-linked recessive ichthyosis STS Steroid sulfatase 49 Lamellar ichthyosis TGM1 Transglutaminase 1 50 Mutilating keratoderma with ichthyosis LOR Loricrin 10 Vohwinkel’s syndrome GJB2 Connexin 26 12 PPK with deafness GJB2 Connexin 26 12 Erythrokeratodermia variabilis GJB3, GJB4 Connexins 31 and 30.3 12 Darier disease ATP2A2 ATP-dependent calcium 14 transporter Striate PPK DSP, DSG1 Desmoplakin, desmoglein 1 51, 52 Conradi-Hu¨nermann-Happle syndrome EBP Delta 8-delta 7 sterol isomerase 53 (emopamil binding protein) Mal de Meleda ARS SLURP-1 -
A Deep Learning System for Differential Diagnosis of Skin Diseases
A deep learning system for differential diagnosis of skin diseases 1 1 1 1 1 1,2 † Yuan Liu , Ayush Jain , Clara Eng , David H. Way , Kang Lee , Peggy Bui , Kimberly Kanada , ‡ 1 1 1 Guilherme de Oliveira Marinho , Jessica Gallegos , Sara Gabriele , Vishakha Gupta , Nalini 1,3,§ 1 4 1 1 Singh , Vivek Natarajan , Rainer Hofmann-Wellenhof , Greg S. Corrado , Lily H. Peng , Dale 1 1 † 1, 1, 1, R. Webster , Dennis Ai , Susan Huang , Yun Liu * , R. Carter Dunn * *, David Coz * * Affiliations: 1 G oogle Health, Palo Alto, CA, USA 2 U niversity of California, San Francisco, CA, USA 3 M assachusetts Institute of Technology, Cambridge, MA, USA 4 M edical University of Graz, Graz, Austria † W ork done at Google Health via Advanced Clinical. ‡ W ork done at Google Health via Adecco Staffing. § W ork done at Google Health. *Corresponding author: [email protected] **These authors contributed equally to this work. Abstract Skin and subcutaneous conditions affect an estimated 1.9 billion people at any given time and remain the fourth leading cause of non-fatal disease burden worldwide. Access to dermatology care is limited due to a shortage of dermatologists, causing long wait times and leading patients to seek dermatologic care from general practitioners. However, the diagnostic accuracy of general practitioners has been reported to be only 0.24-0.70 (compared to 0.77-0.96 for dermatologists), resulting in over- and under-referrals, delays in care, and errors in diagnosis and treatment. In this paper, we developed a deep learning system (DLS) to provide a differential diagnosis of skin conditions for clinical cases (skin photographs and associated medical histories). -
Health Effects of Artificial Light 1
http://www.greenfacts.org/ Copyright © DG Health and Consumers of the European Commission. page 1/17 http://ec.europa.eu/health/scientific_committees/policy/opinions_plain_language/index_en.htm Source document: Health Effects of Artificial SCENIHR (2012) Light Summary & Details: GreenFacts Level 2 - Details on Health Effects of Artificial Light 1. Why is artificial light a concern?................................................................................2 2. How do artificial lights work?.....................................................................................2 3. How does light affect living organisms?..................................................................4 3.1 What is light and how is it absorbed and measured?............................................................4 3.2 How can light affect biological systems?.............................................................................5 4. What effects on health have been observed?.........................................................5 4.1 Thermal and chemical effects...........................................................................................5 4.2 Effects on the eyes..........................................................................................................6 4.3 Effects on the sleep, mood and the circacian rhythm...........................................................6 5. What are the effects on people who have conditions that make them sensitive to light?.............................................................................................................................7 -
Latest Evidence Regarding the Effects of Photosensitive Drugs on the Skin
pharmaceutics Review Latest Evidence Regarding the Effects of Photosensitive Drugs on the Skin: Pathogenetic Mechanisms and Clinical Manifestations Flavia Lozzi 1, Cosimo Di Raimondo 1 , Caterina Lanna 1, Laura Diluvio 1, Sara Mazzilli 1, Virginia Garofalo 1, Emi Dika 2, Elena Dellambra 3 , Filadelfo Coniglione 4, Luca Bianchi 1,* and Elena Campione 1,* 1 Dermatology Unit, Department of Internal Medicine, Tor Vergata University, 00133 Rome, Italy; fl[email protected] (F.L.); [email protected] (C.D.R.); [email protected] (C.L.); [email protected] (L.D.); [email protected] (S.M.); [email protected] (V.G.) 2 Dermatology Unit, Department of Experimental, Diagnostic and Specialty Medicine-DIMES, University of Bologna, Via Massarenti, 1-40138 Bologna, Italy; [email protected] 3 Laboratory of Molecular and Cell Biology, Istituto Dermopatico dell’Immacolata–Istituto di Ricovero e Cura a Carattere Scientifico (IDI-IRCCS), via dei Monti di Creta 104, 00167 Rome, Italy; [email protected] 4 Department of Clinical Science and Translational Medicine, Tor Vergata University, 00133 Rome, Italy; fi[email protected] * Correspondence: [email protected] (L.B.); [email protected] (E.C.); Tel.: +39-0620908446 (E.C.) Received: 5 October 2020; Accepted: 2 November 2020; Published: 17 November 2020 Abstract: Photosensitivity induced by drugs is a widely experienced problem, concerning both molecule design and clinical practice. Indeed, photo-induced cutaneous eruptions represent one of the most common drug adverse events and are frequently an important issue to consider in the therapeutic management of patients. Phototoxicity and photoallergy are the two different pathogenic mechanisms involved in photosensitization. -
Dermatopathology A-Z Vladimir Vincek
Dermatopathology A-Z Vladimir Vincek Dermatopathology A-Z A Comprehensive Guide Vladimir Vincek Department of Dermatology College of Medicine University of Florida Gainesville, FL USA ISBN 978-3-319-89485-0 ISBN 978-3-319-89486-7 (eBook) https://doi.org/10.1007/978-3-319-89486-7 Library of Congress Control Number: 2018951196 © Springer International Publishing AG, part of Springer Nature 2018 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifically the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfilms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. The use of general descriptive names, registered names, trademarks, service marks, etc. in this publication does not imply, even in the absence of a specific statement, that such names are exempt from the relevant protective laws and regulations and therefore free for general use. The publisher, the authors, and the editors are safe to assume that the advice and information in this book are believed to be true and accurate at the date of publication. Neither the publisher nor the authors or the editors give a warranty, express or implied, with respect to the material contained herein or for any errors or omissions that may have been made. The publisher remains neutral with regard to jurisdictional claims in published maps and institutional affiliations. This Springer imprint is published by the registered company Springer Nature Switzerland AG The registered company address is: Gewerbestrasse 11, 6330 Cham, Switzerland This book is dedicated to my parents, who provided me with an enriching childhood, to my wife for all of her patience, understanding, and support, and to my children for some unforgettable moments that always brighten my days. -
DRUG-INDUCED PHOTOSENSITIVITY (Part 1 of 4)
DRUG-INDUCED PHOTOSENSITIVITY (Part 1 of 4) DEFINITION AND CLASSIFICATION Drug-induced photosensitivity: cutaneous adverse events due to exposure to a drug and either ultraviolet (UV) or visible radiation. Reactions can be classified as either photoallergic or phototoxic drug eruptions, though distinguishing between the two reactions can be difficult and usually does not affect management. The following criteria must be met to be considered as a photosensitive drug eruption: • Occurs only in the context of radiation • Drug or one of its metabolites must be present in the skin at the time of exposure to radiation • Drug and/or its metabolites must be able to absorb either visible or UV radiation Photoallergic drug eruption Phototoxic drug eruption Description Immune-mediated mechanism of action. Response is not dose-related. More frequent and result from direct cellular damage. May be dose- Occurs after repeated exposure to the drug dependent. Reaction can be seen with initial exposure to the drug Incidence Low High Pathophysiology Type IV hypersensitivity reaction Direct tissue injury Onset >24hrs <24hrs Clinical appearance Eczematous Exaggerated sunburn reaction with erythema, itching, and burning Localization May spread outside exposed areas Only exposed areas Pigmentary changes Unusual Frequent Histology Epidermal spongiosis, exocytosis of lymphocytes and a perivascular Necrotic keratinocytes, predominantly lymphocytic and neutrophilic inflammatory infiltrate dermal infiltrate DIAGNOSIS Most cases of drug-induced photosensitivity can be diagnosed based on physical examination, detailed clinical history, and knowledge of drug classes typically implicated in photosensitive reactions. Specialized testing is not necessary to make the diagnosis for most patients. However, in cases where there is no prior literature to support a photosensitive reaction to a given drug, or where the diagnosis itself is in question, implementing phototesting, photopatch testing, or rechallenge testing can be useful. -
Hall (Editor), Gordon C
Sauer's Manual of Skin Diseases 8th edition (January 15, 2000): by John C. Hall (Editor), Gordon C. Manual of Skin Diseases Sauer ByLippincott Williams & Wilkins Publishers By OkDoKeY Sauer’s Manual of Skin Diseases Contents Dedication Contributing Authors Preface to the First Edition (abridged) Preface Acknowledgments Chapter 1 Structure of the Skin Kenneth R. Watson, D.O. Chapter 2 Laboratory Procedures and Tests Kenneth R. Watson, D.O. Chapter 3 Dermatologic Diagnosis Chapter 4 Introduction to the Patient Chapter 5 Dermatologic Therapy Chapter 6 Physical Dermatologic Therapy Chapter 7 Fundamentals of Cutaneous Surgery Frank Custer Koranda, M.D. Chapter 8 Cosmetics for the Physician Marianne N. O’Donoghue,M.D. Chapter 9 Dermatologic Allergy Chapter 10 Dermatologic Immunology Richard S. Kalish, M.D., Ph.D. Chapter 11 Pruritic Dermatoses Chapter 12 Vascular Dermatoses Chapter 13 Seborrheic Dermatitis, Acne, and Rosacea Chapter 14 Papulosquamous Dermatoses Chapter 15 Dermatologic Bacteriology Chapter 16 Spirochetal Infections Chapter 17 Dermatologic Virology Chapter 18 Cutaneous Disease Associated with Human Immunodeficiency Virus M. Joyce Rico, M.D., and Neil S. Prose,M.D. Chapter 19 Dermatologic Mycology Chapter 20 Granulomatous Dermatoses Chapter 21 Dermatologic Parasitology Chapter 22 Bullous Dermatoses Chapter 23 Exfoliative Dermatitis Chapter 24 Pigmentary Dermatoses Chapter 25 Collagen Disease Chapter 26 The Skin and Internal Disease Warren R. Heymann, M.D., and Robin Levin,M.D. Chapter 27 Diseases Affecting the Hair Thelda Kestenbaum, M.D. Chapter 28 Diseases Affecting the Nails Thelda Kestenbaum, M.D. Chapter 29 Diseases of the Mucous Membranes Chapter 30 Dermatologic Reactions to Sun and Radiation Chapter 31 Genodermatoses Virginia P. -
Ultraviolet Radiation and the Skin
Ministry of Defence Synopsis of Causation Ultraviolet radiation and the skin Author: Dr Tony Fisher, Medical Author, Medical Text, Edinburgh Validator: Professor LE Rhodes Photobiology Unit, University of Manchester, Salford Royal Foundation Hospital April 2010 Disclaimer This synopsis has been completed by medical practitioners. It is based on a literature search at the standard of a textbook of medicine and generalist review articles. It is not intended to be a meta- analysis of the literature on the condition specified. Every effort has been taken to ensure that the information contained in the synopsis is accurate and consistent with current knowledge and practice and to do this the synopsis has been subject to an external validation process by consultants in a relevant specialty nominated by the Royal Society of Medicine. The Ministry of Defence accepts full responsibility for the contents of this synopsis, and for any claims for loss, damage or injury arising from the use of this synopsis by the Ministry of Defence. 2 1. Definition 1.1. Ultraviolet radiation (UVR) is a component of the non-ionising part of the electromagnetic spectrum, just beyond the violet end of visible light. It has a wavelength of 100-400 nanometres (nm) and it is arbitrarily classified as UVA (320-400 nm), UVB (280-320 nm) and UVC (100-280 nm).UVA can be further subdivided into UVA I, or far UVA (340-400 nm), and UVA II, or near UVA (320-340 nm). UVR falls beyond the range of human vision but has a number of important effects on health. 1.2. -
Drug-Induced Photosensitivity—An Update Forearms and Hands
Drug Safety https://doi.org/10.1007/s40264-019-00806-5 REVIEW ARTICLE Drug‑Induced Photosensitivity—An Update: Culprit Drugs, Prevention and Management Kim M. Blakely1 · Aaron M. Drucker1,2 · Cheryl F. Rosen1,3 © Springer Nature Switzerland AG 2019 Abstract Photosensitive drug eruptions are cutaneous adverse events due to exposure to a medication and either ultraviolet or visible radiation. In this review, the diagnosis, prevention and management of drug-induced photosensitivity is discussed. Diagnosis is based largely on the history of drug intake and the appearance of the eruption primarily afecting sun-exposed areas of the skin. This diagnosis can also be aided by tools such as phototesting, photopatch testing and rechallenge testing. The mainstay of management is prevention, including informing patients of the possibility of increased photosensitivity as well as the use of appropriate sun protective measures. Once a photosensitivity reaction has occurred, it may be necessary to discontinue the culprit medication and treat the reaction with corticosteroids. For certain medications, long-term surveillance may be indicated because of a higher risk of developing melanoma or squamous cell carcinoma at sites of earlier photosensitivity reactions. A large number of medications have been implicated as causes of photosensitivity, many with convincing clinical and scientifc supporting evidence. We review the medical literature regarding the evidence for the culpability of each drug, including the results of phototesting, photopatch testing and rechallenge testing. Amiodarone, chlorpromazine, doxycycline, hydrochlorothiazide, nalidixic acid, naproxen, piroxicam, tetracycline, thioridazine, vemurafenib and voriconazole are among the most consistently implicated and warrant the most precaution by both the physician and patient. -
Health Effects of Artificial Light
Health Effects of Artificial Light Scientific Committee on Emerging and Newly Identified Health Risks SCENIHR Health Effects of Artificial Light The SCENIHR adopted this opinion at its 17th plenary meeting on 19 March 2012 1 Health Effects of Artificial Light About the Scientific Committees Three independent non-food Scientific Committees provide the Commission with the scientific advice it needs when preparing policy and proposals relating to consumer safety, public health and the environment. The Committees also draw the Commission's attention to the new or emerging problems which may pose an actual or potential threat. They are: the Scientific Committee on Consumer Safety (SCCS), the Scientific Committee on Health and Environmental Risks (SCHER) and the Scientific Committee on Emerging and Newly Identified Health Risks (SCENIHR) and are made up of external experts. In addition, the Commission relies upon the work of the European Food Safety Authority (EFSA), the European Medicines Agency (EMA), the European Centre for Disease prevention and Control (ECDC) and the European Chemicals Agency (ECHA). SCENIHR This Committee deals with questions related to emerging or newly identified health and environmental risks and on broad, complex or multidisciplinary issues requiring a comprehensive assessment of risks to consumer safety or public health and related issues not covered by other Community risk assessment bodies. Examples of potential areas of activity include potential risks associated with interaction of risk factors, synergic effects, cumulative effects, antimicrobial resistance, new technologies such as nanotechnologies, medical devices including those incorporating substances of animal and/or human origin, tissue engineering, blood products, fertility reduction, cancer of endocrine organs, physical hazards such as noise and electromagnetic fields (from mobile phones, transmitters and electronically controlled home environments), and methodologies for assessing new risks. -
Global Burden of Skin Disease As Reflected in Cochrane Database Of
Supplementary Online Content Karimkhani C, Boyers LN, Prescott L, et al. Global Burden of Skin Disease in 2010 and Skin Disease Systematic Reviews and Protocols in Cochrane Database of Systematic Reviews. Published online May 7, 2014. JAMA Dermatology. doi:10.1001/jamadermatol.2014.709. eTable 1. Terms entered into search query for “other skin and subcutaneous diseases” category with GBD 2010 ICD-10 code definitions eTable 2. Titles for all reviews and protocols included for the 15 skin conditions studied by GBD 2010 and associated Cochrane Group responsible for publication eTable 3. Excluded titles generated from search of 15 skin conditions studied by GBD 2010 in The Cochrane Database of Systematic Reviews eTable 4. Titles for all reviews and protocols included for the “other skin and subcutaneous diseases” category studied by GBD 2010 and associated Cochrane Group responsible for publication eTable 5. Excluded titles generated from search of GBD 2010 “other skin and subcutaneous diseases” category in The Cochrane Database of Systematic Reviews This supplementary material has been provided by the authors to give readers additional information about their work. © 2013 American Medical Association. All rights reserved. Downloaded From: https://jamanetwork.com/ on 09/29/2021 2 eTable 1. Terms entered into search query for “other skin and subcutaneous diseases” category with GBD 2010 ICD-10 code definitionsa GBD “other skin and subcutaneous diseases” Abstract/project terms supporting category (ICD-10 code) inclusion Pediculosis and phthiriasis