Global Burden of Skin Disease As Reflected in Cochrane Database Of

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Supplementary Online Content

Karimkhani C, Boyers LN, Prescott L, et al. Global Burden of Skin Disease in 2010 and Skin Disease Systematic Reviews and Protocols in Cochrane Database of Systematic Reviews. Published online May 7, 2014. JAMA Dermatology. doi:10.1001/jamadermatol.2014.709.

eTable 1. Terms entered into search query for “other skin and subcutaneous diseases” category with GBD 2010 ICD-10 code definitions

eTable 2. Titles for all reviews and protocols included for the 15 skin conditions studied by GBD 2010 and associated Cochrane Group responsible for publication

eTable 3. Excluded titles generated from search of 15 skin conditions studied by GBD 2010 in The Cochrane Database of Systematic Reviews

eTable 4. Titles for all reviews and protocols included for the “other skin and subcutaneous diseases” category studied by GBD 2010 and associated Cochrane Group responsible for publication

eTable 5. Excluded titles generated from search of GBD 2010 “other skin and subcutaneous diseases” category in The Cochrane Database of Systematic Reviews

This supplementary material has been provided by the authors to give readers additional information about their work.

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eTable 1. Terms entered into search query for “other skin and subcutaneous diseases” category with GBD 2010 ICD-10 code definitionsa

GBD “other skin and subcutaneous diseases” Abstract/project terms supporting category (ICD-10 code) inclusion

Pediculosis and phthiriasis (B85) “pediculosis” “phthiriasis”

Myiasis (B87) “myiasis”

Other infestations (B88) “ acariasis” “tungiasis” or “sandflea” “scarabiasis” or “arthropod” “hirudiniasis” or “leech” “ichthyoparasitism” “ vandellia cirrhosa, “linguatulosis” “porocephaliasis” “skin infestation” “mites” “skin parasites” Pilonidal cyst with and without abscess (L05.0 and “pilonidal cyst” L05.9) Pemphigus (L10) “pemphigus” Other acantholytic disorders (L11) “keratosis follicularis” “acantholytic dermatosis” “acantholytic” Pemphigoid (L12) “pemphigoid” “bullous” or “bulla” “epidermolysis bullosa”

Other bullous disorders (L13) “dermatitis herpetiformis” “subcorneal pustular dermatitis” “bullous” “bulla” Lichen simplex chronicus and prurigo (L28) “lichen simplex chronicus” “prurigo”

Other dermatitis (L30) “nummular dermatitis” “dyshidrosis” “cutaneous autosensitization” “infective dermatitis” “erythema intertrigo “pityriasis alba” Pityriasis rosea (L42) “pityriasis rosea”

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Lichen planus (l42) “lichen planus” Other papulosquamous disorders (L44) “pityriasis rubra pilaris” “lichen nitidus” “lichen striatus” “lichen ruber moniliformis” “infantile papular acrodermatitis” or “Giannotti-Crosti” “papulosquamous” Erythema multiforme (L51) “erythema multiforme” “Stevens Johnson” Erythema nodosum (L52) “erythema nodosum” Other erythematous conditions (L53) “toxic erythema” “erythema annulare centrifugum” “erythema marginatum” “chronic figurate erythema” Sunburn (L55) “sunburn” Other acute skin changes due to ultraviolet “drug phototoxic” radiation (L56) “drug photoallergic” “photocontact dermatitis” “solar urticaria” “polymorphous light eruption” “acute” and “UV” or “ultraviolet” Skin changes due to chronic exposure to “actinic keratosis” nonionizing radiation (L57) “actinic reticuloid” “cutis rhomboidalis nuchae” “poikiloderma of Civatte” “cutis laxa senilis” “actinic granuloma” “nonionizing radiation” “wrinkles” “chronic” and “UV” or “ultraviolet” “tanning” Radiodermatitis (L58) “radiodermatitis” Other disorders of skin and subcutaneous tissue “erythema ab igne” related to radiation (L59) “dermatitis ab igne” Nail disorder (L60) “nail” “ingrowing” “onycholysis” “onychogryphosis” “Beau lines” “yellow nail syndrome” Androgenic alopecia (L64) “androgenic alopecia” Other nonscarring hair loss (L65) “telogen effluvium” “anagen effluvium” “alopecia mucinosa” “nonscarring”

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“hair loss” “alopecia” Cicatricial alopecia (scarring hair loss) (L66) “pseudopelade” “lichen planopilaris” “folliculitis decalvans” “perifolliculitis capitis abscedens” “folliculitis ulerythematosa reticulate” “cicatricial” “scarring” “hair loss” “alopecia” Hair color and hair shaft abnormalities (L67) “trichorrhexis nodosa” “hair color” “hair shaft” Hypertrichosis (L68) “hirsutism” “hypertrichosis” “polytrichia” Rosacea (L71) “rosacea” “perioral dermatitis” “rhinophyma” Follicular cysts of skin and subcutaneous tissue “cyst” (L72) “follicular” “epidermal” “trichilemmal” “steatocystoma” Other follicular disorders (L73) “acne keloid” “pseudofolliculitis barbae” “hidradenitis suppurativa” Eccrine sweat disorders (L74) “eccrine sweat” “miliaria” “anhydrosis” apocrine sweat disorder (L75) “apocrine sweat” “bromhidrosis” “chromhidrosis” “apocrine miliaria” Vitiligo (L80) “vitiligo” Other disorders of pigmentation (L81) “hyperpigmentation” “chloasma” “freckles” “café au lait spots” “leukoderma” “hypopigmentation” [excluding “vitiligo] “pigmented purpuric dermatosis” “iron pigmentation” “tattoo pigmentation” Seborrhoeic keratosis (L82) “seborrhoeic keratosis”

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Acanthosis nigricans (L83) “acanthosis nigricans” Corns and callosities (L84) “corn” “callous” Other epidermal thickening (L85) “(acquired) icthyosis” “keratoderma” “(acquired)keratosis” “xerosis cutis” “epidermal thickening” Transepidermal elimination disorders (L87) “keratosis follicularis et parafollicularis in cutem penetrans” “reactive perforating collagenosis” “elastosis perforans serpiginosa” “transepidermal” Atrophic disorders of skin (L90) “lichen sclerosis” “anetoderma” “atrophoderma” “acrodermatitis chronica atrophicans” “adherent scar” “cicatrix” “striae atrophicae” Hypertrophic disorders of skin (L91) “hypertrophic scar” “keloid” Granulomatous disorders of skin and subcutaneous “granuloma annulare” tissue (L92) “necrobiosis lipoidica” “granuloma faciale” “eosinophilic granuloma of skin” “foreign body granuloma” and “skin” Lupus erythematosus (L93) “discoid” “cutaneous” and “lupus” “local” and “lupus” Other localized connective tissue disorders (L94) “localized scleroderma” “morphea” “linear scleroderma” “calcinosis cutis” “sclerodactyly” “Gottron papules” “poikiloderma vasculare atrophicans” “ainhum” L95: Vasculitis limited to skin, not elsewhere “livedoid vascultitis” classified (L95) “erythema elevatum diutinum” “vasculitits” and “skin” a Specific ICD-10 and ICD-9 codes used by GBD 2010 for the “other skin and subcutaneous diseases” category are published in: Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, et al. Supplementary appendix to: Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet. 2012 Dec 13; 380: 2095–2128.

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eTable 2: Titles for all reviews and protocols included for the 15 skin conditions studied by GBD 2010 and associated Cochrane Group responsible for publication

Skin Condition Review (R) or Protocol (P) Title Cochrane Group Dermatitis Oral H1 antihistamines as monotherapy for eczema (R) Skin Group Dermatitis Probiotics for treating eczema (R) Skin Group Dermatitis Topical pimecrolimus for eczema (R) Skin Group Dermatitis Interventions to reduce Staphylococcus aureus in the Skin Group management of atopic eczema (R) Dermatitis Chinese herbal medicine for atopic eczema (R) Skin Group Dermatitis Oral evening primrose oil and borage oil for eczema (R) Skin Group Dermatitis Dietary exclusions for established atopic eczema (R) Skin Group Dermatitis Psychological and educational interventions for atopic eczema in Skin Group children (R) Dermatitis Dietary supplements for established atopic eczema (R) Skin Group Dermatitis Prebiotics in infants for prevention of allergy (R) Neonatal Group Dermatitis Probiotics in infants for prevention of allergic disease and food Neonatal Group hypersensitivity (R) Dermatitis Formulas containing hydrolysed protein for prevention of allergy Neonatal Group and food intolerance in infants (R) Dermatitis Soy formula for prevention of allergy and food intolerance in Neonatal Group infants (R) Dermatitis Maternal dietary antigen avoidance during pregnancy or lactation, Pregnancy and or both, for preventing or treating atopic disease in the child (R) Childbirth Group Dermatitis Topical cyclosporine for atopic keratoconjunctivitis (R) Eyes and Vision Group Dermatitis Topical Vitamin A, or its derivatives, for treating and preventing Skin Group napkin dermatitis in infants (R) Dermatitis Disposable nappies for preventing napkin dermatitis in infants (R) Skin Group Dermatitis Interventions for preventing occupational irritant hand dermatitis Skin Group (R) Dermatitis House dust mite reduction and avoidance measures for treating Skin Group eczema (P) Dermatitis Interventions for hand eczema (P) Skin Group Dermatitis Specific allergen immunotherapy for the treatment of atopic Skin Group eczema (P) Dermatitis Topical tacrolimus for atopic dermatitis (P) Skin Group Dermatitis Emollients for eczema (P) Skin Group Dermatitis Different strategies for using topical corticosteroids for established Skin Group eczema (P) Dermatitis Interventions for seborrhoeic dermatitis (P) Skin Group Dermatitis Topical anti-inflammatory agents for seborrhoeic dermatitis of the Skin Group face or scalp (P) Acne vulgaris Minocycline for acne vulgaris: efficacy and safety (R) Skin Group Acne vulgaris Laser resurfacing for facial acne scars (R) Skin Group Acne vulgaris Spironolactone versus placebo or in combination with steroids for Menstrual hirsutism and/or acne (R) Disorders and Subfertility Group Acne vulgaris Insulin‐sensitising drugs versus the combined oral contraceptive Menstrual pill for hirsutism, acne and risk of diabetes, cardiovascular Disorders and disease, and endometrial cancer in polycystic ovary syndrome (R) Subfertility Group Acne vulgaris Statins for women with polycystic ovary syndrome not actively Menstrual trying to conceive (R) Disorders and Subfertility Group

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Skin Condition Review (R) or Protocol (P) Title Cochrane Group Acne vulgaris Combined oral contraceptive pills for treatment of acne (R) Fertility Regulation Group Acne vulgaris Complementary therapies for acne vulgaris (P) Skin Group Acne vulgaris Oral isotretinoin for acne (P) Skin Group Acne vulgaris Light therapies for acne (P) Skin Group Acne vulgaris Ovarian surgery for symptom relief in women with polycystic Menstrual ovarian syndrome (P) Disorders and Subfertility Group Bacterial skin Interventions to reduce Staphylococcus aureus in the Skin Group diseases management of atopic eczema (R) Bacterial skin Interventions for impetigo (R) Skin Group diseases Bacterial skin Interventions of cellulitis and erysipelas (R) Skin Group diseases Bacterial skin Antibiotics for treating scrub typhus (R) Infectious diseases Diseases Group Bacterial skin Interventions for the prevention of recurrent erysipelas and Skin Group diseases cellulitis (P) Viral skin Interventions for cutaneous molluscum contagiosum (R) Skin Group diseases Viral skin Topical treatments for cutaneous warts (R) Skin Group diseases Viral skin Medical interventions for high grade vulval intraepithelial neoplasia Skin Group diseases (R) Viral skin Interventions for anal canal intraepithelial neoplasia (R) Skin Group diseases Viral skin Vaccines for preventing herpes zoster in older adults (R) Acute diseases Respiratory Infections Group Viral skin Vaccines for post‐exposure prophylaxis against varicella Acute diseases (chickenpox) in children and adults (R) Respiratory Infections Group Viral skin Interventions for prevention of herpes simplex labialis (cold sores Skin Group diseases on the lips) (P) Viral skin Interventions for treatment of herpes simplex labialis (cold sores Skin Group diseases on the lips) (P) Viral skin Management of herpes zoster ophthalmicus in people with HIV HIV/AIDs Group diseases infection (P) Urticaria Histamine H2‐receptor antagonists for urticaria (R) Skin Group Urticaria H1-antihistamines for chronic urticaria (P) Skin Group Fungal skin Topical treatments for fungal infections of the skin and nails of the Skin Group diseases foot (R) Fungal skin Oral treatments for fungal infections of the skin of the foot (R) Skin Group diseases Fungal skin Systemic antifungal therapy for tinea capitis in children (R) Skin Group diseases Fungal skin Oral potassium iodide for the treatment of sporotrichosis (R) Skin Group diseases Skin Condition Review (R) or Protocol (P) Title Cochrane Group Fungal skin Oral antifungal medication for toenail onychomycosis (P) Skin Group diseases Fungal skin Topical antifungal treatments for tinea cruris and tinea corporis (P) Skin Group diseases

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Pruritus Pharmacological interventions for pruritus in adult palliative care Pain, Palliative, patients (R) and Supportive Care Group Pruritus Drugs for the prevention and treatment of pruritus in patients Anaesthesia receiving neuraxial opioids (P) Group Scabies Interventions for treating scabies (R) Infectious Diseases Group Scabies Treatment of close contacts of people with scabies for preventing Occupational re‐infestation or spread of infestation in contacts (P) Safety and Health Group Alopecia areata Interventions for alopecia areata (R) Skin Group Cellulitis Interventions for cellulitis and erysipelas (R) Skin Group Cellulitis Interventions for the prevention of recurrent erysipelas and Skin Group cellulitis (P) Decubitus ulcer Support surfaces for pressure ulcer prevention (R) Wounds Group Decubitus ulcer Wound cleansing for pressure ulcers (R) Wounds Group Decubitus ulcer Pressure‐relieving devices for treating heel pressure ulcers (R) Wounds Group

Decubitus ulcer Therapeutic ultrasound for pressure ulcers (R) Wounds Group Decubitus ulcer Risk assessment tools for the prevention of pressure ulcers (R) Wounds Group Decubitus ulcer Support surfaces for treating pressure ulcers (R) Wounds Group Decubitus ulcer Repositioning for treating pressure ulcers (R) Wounds Group Decubitus ulcer Electromagnetic therapy for treating pressure ulcers (R) Wounds Group Decubitus ulcer Nutritional interventions for preventing and treating pressure ulcers Wounds Group (R) Decubitus ulcer Dressings and topical agents for preventing pressure ulcers (R) Wounds Group Decubitus ulcer Massage therapy for preventing pressure ulcers (P) Wounds Group Decubitus ulcer Hydrocolloid dressings for treating pressure ulcers (P) Wounds Group Decubitus ulcer Topical phenytoin for treating pressure ulcers (P) Wounds Group Decubitus ulcer Phototherapy for treating pressure ulcers (P) Wounds Group Decubitus ulcer Repositioning for pressure ulcer prevention in adults (P) Wounds Group Melanoma Surgical excision margins for primary cutaneous melanoma (R) Skin Group Melanoma Statins and fibrates for preventing melanoma (R) Skin Group Melanoma Chemoimmunotherapy versus chemotherapy for metastatic Skin Group malignant melanoma (R) Melanoma Systemic treatments for metastatic cutaneous melanoma (R) Skin Group Melanoma Interferon alpha for the adjuvant treatment of cutaneous Skin Group melanoma (R) Melanoma Interventions for melanoma in situ, including lentigo maligna (P) Skin Group Melanoma Sentinel lymph node biopsy followed by lymph node dissection for Skin Group early cutaneous melanoma (P) Psoriasis Antistreptococcal interventions for guttate and chronic plaque Skin Group psoriasis (R) Psoriasis Interventions for nail psoriasis (R) Skin Group Psoriasis Topical treatments for chronic plaque psoriasis (R) Skin Group Psoriasis Interventions for guttate psoriasis (R) Skin Group Skin Condition Review (R) or Protocol (P) Title Cochrane Group Psoriasis Narrow‐band ultraviolet B phototherapy versus broad‐band Skin Group ultraviolet B or psoralen‐ultraviolet A photochemotherapy for psoriasis (R) Psoriasis Interventions for chronic palmoplantar pustulosis (R) Skin Group Psoriasis Interventions for treating psoriatic arthritis (R) Musculoskeletal Group Psoriasis Anti-TNF agents for paediatric psoriasis (P) Skin Group

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Psoriasis Oral fumaric acid esters for psoriasis (P) Skin Group Psoriasis Methotrexate for psoriasis (P) Skin Group Psoriasis Topical treatments for scalp psoriasis (P) Skin Group Non-melanoma Interventions for non‐metastatic squamous cell carcinoma of the Skin Group skin cancer skin (R) Non-melanoma Interventions for cutaneous Bowen's disease (R) Skin Group skin cancer Non-melanoma Interventions for preventing non‐melanoma skin cancers in high‐ Skin Group skin cancer risk groups (R) Non-melanoma Interventions for basal cell carcinoma of the skin (R) Skin Group skin cancer Non-melanoma Mohs micrographic surgery versus surgical excision for periocular Eyes and Vision skin cancer basal cell carcinoma (R) Group Non-melanoma Selenium for preventing cancer (R) Gynaecological skin cancer Group Leprosy Interventions for skin changes caused by nerve damage in leprosy Skin Group (R) Leprosy Interventions for erythema nodosum leprosum (R) Skin Group Leprosy Decompressive surgery for treating nerve damage in leprosy (R) Cochrane Neuromuscular Disease Group Leprosy Corticosteroids for treating nerve damage in leprosy (R) Cochrane Neuromuscular Disease Group

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eTable 3: Excluded titles generated from search of 15 skin conditions studied by GBD 2010 in The Cochrane Database of Systematic Reviews Searched Skin Review (R) or Protocol (P) Excluded Excluded Condition without after Discrepancy Consensus Review Dermatitis Low molecular weight heparin for prevention X of venous thromboembolism in patients with lower-leg immobilization (R)

Dermatitis Optimal duration of exclusive breastfeeding X (R)

Dermatitis Psychological interventions for parents of X children and adolescents with chronic illness (R)

Dermatitis Tartrazine exclusion for allergic asthma(R) X

Dermatitis Gold as an oral corticosteroid sparing agent in X stable asthma (R)

Acne vulgaris Testosterone for peri and postmenopausal X women (R)

Acne vulgaris Dehydroepiandrosterone for systemic lupus X erythematosus (R)

Acne vulgaris Lifestyle changes in women with polycystic X ovary syndrome (R)

Acne vulgaris Skin patch and vaginal ring versus combined X oral contraceptives for contraception (R) Acne vulgaris Metformin treatment before and during IVF or X ICSI in women with polycystic ovary syndrome (R)

Acne vulgaris Insulin-sensitising drugs (metformin, X rosiglitazone, pioglitazone, D-chiro-inositol) for women with polycystic ovary syndrome, oligo amenorrhoea and subfertility (R)

Acne vulgaris Danazol for heavy menstrual bleeding (R) X

Acne vulgaris Danazol for uterine fibroids (R) X

Acne vulgaris Corticosteroids for treating optic neuritis (R) X

Acne vulgaris Progestagens and anti-progestagens for pain X associated with endometriosis (R) Acne vulgaris Interventions for melasma (R) X

Acne vulgaris Interventions for rosacea (R) X

Acne vulgaris Gonadotrophin-releasing hormone analogues X for endometriosis: bone mineral density (R)

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Searched Skin Review (R) or Protocol (P) Excluded Excluded Condition without after Discrepancy Consensus Review Acne vulgaris Anti-inflammatory treatment for carditis in X acute rheumatic fever (R)

Acne vulgaris Quadriphasic versus monophasic oral X contraceptives for contraception (R)

Acne vulgaris Danazol for pelvic pain associated with X endometriosis (R)

Bacterial skin Beta lactam antibiotic monotherapy versus X diseases beta lactam-aminoglycoside antibiotic combination therapy for sepsis (R) Bacterial skin Third generation cephalosporins versus X diseases conventional antibiotics for treating acute bacterial meningitis (R)

Bacterial skin Different classes of antibiotics given to women X diseases routinely for preventing infection at caesarean section (R)

Bacterial skin Topical ointment for preventing infection in X diseases preterm infants (R)

Bacterial skin Skin preparation with alcohol versus alcohol X diseases followed by any antiseptic for preventing bacteraemia or contamination of blood for transfusion (R)

Bacterial skin Antibiotic prophylaxis for preventing burn X diseases wound infection (R)

Bacterial skin Antibiotics to reduce post-tonsillectomy X diseases morbidity (R)

Bacterial skin Antibiotics for acute maxillary sinusitis (R) X diseases Bacterial skin Additional anti-Gram-positive antibiotic X diseases treatment for febrile neutropenic cancer patients (R)

Bacterial skin Percutaneous lines for delivering intravenous X diseases antibiotics in people with cystic fibrosis (R)

Bacterial skin Early versus delayed dressing removal after X diseases primary closure of clean and clean- contaminated surgical wounds (R)

Bacterial skin Antistreptococcal interventions for guttate and X diseases chronic plaque psoriasis (R)

Searched Skin Review (R) or Protocol (P) Excluded Excluded Condition without after Discrepancy Consensus

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Review Bacterial skin Minocycline for acne vulgaris: efficacy and X diseases safety (R)

Bacterial skin Quinolones for uncomplicated acute cystitis in X diseases women (R) Bacterial skin Antibiotic prophylaxis versus no prophylaxis X diseases for preventing infection after cesarean section (R)

Bacterial skin Face washing promotion for preventing active X diseases trachoma (R)

Bacterial skin Dietary exclusions for established atopic X diseases eczema (R)

Bacterial skin Teicoplanin versus vancomycin for proven or X diseases suspected infection (R)

Bacterial skin Interventions for treating leg ulcers in people X diseases with sickle cell disease (R)

Bacterial skin Removal of nail polish and finger rings to X diseases prevent surgical infection (R)

Bacterial skin Vaccines for post-exposure prophylaxis X diseases against varicella (chickenpox) in children and adults (R)

Bacterial skin Vaccines for preventing anthrax (R) X diseases Bacterial skin Umbilical cord antiseptics for preventing X diseases sepsis and death among newborns (R)

Bacterial skin Routine perineal shaving on admission in X diseases labour (R)

Bacterial skin De-escalation of antimicrobial treatment for X diseases adults with sepsis, severe sepsis or septic shock (R)

Bacterial skin Early versus late pre-intensive care unit X diseases admission broad spectrum antibiotics for severe sepsis in adults (R)

Bacterial skin Gauze and tape and transparent polyurethane X diseases dressings for central venous catheters (R)

Searched Skin Review (R) or Protocol (P) Excluded Excluded Condition without after Discrepancy Consensus Review Bacterial skin Antibiotics / anti-inflammatories for reducing X diseases acute inflammatory episodes in lymphoedema of the limbs (R)

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Bacterial skin Interventions for chronic blepharitis (R) X diseases Bacterial skin Mupirocin ointment for preventing X diseases Staphylococcus aureus infections in nasal carriers (R) Bacterial skin Interventions for the management of dry X diseases mouth: non-pharmacological interventions (R)

Bacterial skin Interventions for guttate psoriasis (R) X diseases Bacterial skin Infant position in neonates receiving X diseases mechanical ventilation (R)

Viral skin Dietary exclusions for established atopic X diseases eczema (R) Viral skin Physical interventions to interrupt or reduce X diseases the spread of respiratory viruses(R)

Viral skin Antibiotics for acute maxillary sinusitis (R) X diseases Viral skin Immunotherapy for advanced renal cell X diseases cancer (R)

Urticaria Prebiotics in infants for prevention of allergy X (R) Urticaria Maternal dietary antigen avoidance during X pregnancy or lactation, or both, for preventing or treating atopic disease in the child (R)

Urticaria Soy formula for prevention of allergy and food X intolerance in infants (R)

Urticaria Prenatal administration of progesterone for X preventing preterm birth in women considered to be at risk of preterm birth(R)

Urticaria Oral H1 antihistamines as monotherapy for X eczema (R)

Fungal skin Topical ointment for preventing infection in X diseases preterm infants (R) Fungal skin Prophylactic oral/topical non-absorbed X diseases antifungal agents to prevent invasive fungal infection in very low birth weight infants (R)

Searched Skin Review (R) or Protocol (P) Excluded Excluded Condition without after Discrepancy Consensus Review Fungal skin Additional anti-Gram-positive antibiotic X diseases treatment for febrile neutropenic cancer patients (R) Pruritus Interventions for treating cholestasis in X pregnancy (R)

Pruritus Methotrexate for primary biliary cirrhosis (R) X

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Pruritus Horse chestnut seed extract for chronic X venous insufficiency (R)

Pruritus Ursodeoxycholic acid for primary biliary X cirrhosis (R)

Pruritus Colchicine for primary biliary cirrhosis (R) X

Pruritus Cyclosporin A for primary biliary cirrhosis (R) X

Pruritus Combined spinal-epidural versus epidural X analgesia in labour (R)

Pruritus Phlebotonics for haemorrhoids (R) X Pruritus Laxatives for the treatment of hemorrhoids (R) X

Pruritus Drug therapy for preventing post-dural X puncture headache (R)

Pruritus Pain management for women in labour: an X overview of systematic reviews (R) Pruritus Bezafibrate for primary biliary cirrhosis (R) X

Pruritus Azathioprine for primary biliary cirrhosis (R) X

Pruritus Linezolid versus vancomycin for skin and soft X tissue infections (R)

Pruritus Different antibiotic regimens for treating X asymptomatic bacteriuria in pregnancy (R)

Pruritus Topical interventions for genital lichen X sclerosus (R)

Pruritus Local anaesthetic wound infiltration and X abdominal nerves block during caesarean section for postoperative pain relief (R)

Pruritus D-penicillamine for primary biliary cirrhosis (R) X

Searched Skin Review (R) or Protocol (P) Excluded Excluded Condition without after Discrepancy Consensus Review Pruritus Patient controlled opioid analgesia versus X conventional opioid analgesia for postoperative pain (R)

Pruritus Neuromodulators for pain management in X rheumatoid arthritis (R)

Pruritus Rituximab for relapsing-remitting multiple X sclerosis (R)

Decubitus ulcer Pressure-relieving interventions for treating X diabetic foot ulcers (R)

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Decubitus ulcer Honey as a topical treatment for wounds (R) X

Decubitus ulcer Compression for preventing recurrence of X venous ulcers (R)

Decubitus ulcer Effectiveness of organisational infrastructures X to promote evidence-based nursing practice (R)

Decubitus ulcer Endovenous thermal ablation for healing X venous ulcers and preventing recurrence (R)

Decubitus ulcer Therapeutic ultrasound for venous leg ulcers X (R)

Decubitus ulcer Hyperbaric oxygen therapy for chronic X wounds (R)

Decubitus ulcer Dressings for healing venous leg ulcers (R) X

Decubitus ulcer Autologous platelet-rich plasma for treating X chronic wounds (R)

Decubitus ulcer Negative pressure wound therapy for treating X foot wounds in people with diabetes mellitus (R) Decubitus ulcer Aloe vera for treating acute and chronic X wounds (R)

Decubitus ulcer Silver based wound dressings and topical X agents for treating diabetic foot ulcers (R)

Decubitus ulcer Enteral tube feeding for older people with X advanced dementia (R)

Searched Skin Review (R) or Protocol (P) Excluded Excluded Condition without after Discrepancy Consensus Review Decubitus ulcer Negative pressure wound therapy for skin X grafts and surgical wounds healing by primary intention (R)

Decubitus ulcer Antibiotic therapy for the treatment of X methicillin-resistant Staphylococcus aureus (MRSA) in non surgical wounds (R)

Decubitus ulcer Surgery for deep venous incompetence (R) X

Decubitus ulcer Compression stockings for the initial treatment X of varicose veins in patients without venous ulceration (R)

Decubitus ulcer Rofecoxib for osteoarthritis (R) X

Decubitus ulcer Compression therapy for treating stage I and X

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II (Widmer) post-thrombotic syndrome (R)

Decubitus ulcer Injection sclerotherapy for varicose veins (R) X

Decubitus ulcer Pre-operative traction for hip fractures in X adults (R)

Decubitus ulcer Hospital nurse staffing models and patient X and staff-related outcomes (R)

Decubitus ulcer Infant position in neonates receiving X mechanical ventilation (R)

Melanoma Interventions for preventing non-melanoma X skin cancers in high-risk groups (R)

Melanoma Selenium for preventing cancer (R) X

Melanoma Psychosocial interventions to improve quality X of life and emotional wellbeing for recently diagnosed cancer patients (R)

Melanoma Thymic peptides for treatment of cancer X patients (R) Melanoma Mistletoe therapy in oncology (R) X

Melanoma Cryotherapy for liver metastases (R) X

Searched Skin Review (R) or Protocol (P) Excluded Excluded Condition without after Discrepancy Consensus Review Psoriasis Combination therapy for pain management in X inflammatory arthritis (rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, other spondyloarthritis) (R)

Psoriasis Effect of cyclosporine on blood pressure (R) X

Psoriasis Tumour necrosis factor alpha blocking agents X for induction of remission in ulcerative colitis (R)

Non-melanoma Psychosocial interventions to improve quality X skin cancer of life and emotional wellbeing for recently diagnosed cancer patients (R) Non-melanoma Topical interventions for genital lichen X skin cancer sclerosus (R)

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eTable 4: Titles for all reviews and protocols included for the “other skin and subcutaneous diseases” category studied by GBD 2010 and associated Cochrane Group responsible for publication

Skin Condition Review (R) or Protocol (P) Title Cochrane Group Pediculosis Interventions for treating head lice (P) Infectious Diseases Group Pemphigus Interventions for pemphigus vulgaris and pemphigus foliaceus (R) Skin Group Pemphigoid Interventions for mucous membrane pemphigoid and Skin Group epidermolysis bullosa acquisita (R) Pemphigoid Interventions for bullous pemphigoid (R) Skin Group Pityriasis rosea Interventions for pityriasis rosea (R) Skin Group Lichen planus Interventions for erosive lichen planus affecting mucosal sites (R) Skin Group Lichen planus Interventions for treating oral lichen planus (R) Oral Health Group Lichen planus Interventions for cutaneous lichen planus (P) Skin Group Toxic epidermal Interventions for toxic epidermal necrolysis (R) Skin Group necrolysis Actinic Interventions for actinic keratoses (R) Skin Group Keratosis Polymorphic Interventions for polymorphic light eruption (P) Skin Group light eruption Other skin Interventions for photodamaged skin (R) Skin Group changes due to chronic exposure to nonionizing radiation Radiodermatitis Homeopathic medicines for adverse effects of cancer treatments Pain, Palliative, (R) and Supportive Care Group Radiodermatitis Interventions for preventing and managing radiation-induced skin Skin Group reactions in cancer patients (P) Ingrowing nail Interventions for ingrowing toenails (R) Skin Group Androgenic Interventions for female pattern hair loss (R) Skin Group alopecia Hirsutism Cyproterone acetate for hirsutism (R) Menstrual Disorders and Subfertility Group Hirsutism Spironolactone versus placebo or in combination with steroids for Menstrual hirsutism and/or acne (R) Disorders and Subfertility Group Hirsutism Insulin‐sensitising drugs versus the combined oral contraceptive Menstrual pill for hirsutism , acne and risk of diabetes, cardiovascular Disorders and disease, and endometrial cancer in polycystic ovary syndrome (R) Subfertility Group Hirsutism Laser and photoepilation for unwanted hair growth (R) Skin Group Hirsutism Statins for women with polycystic ovary syndrome not actively Menstrual trying to conceive (R) Disorders and Subfertility Group Hirsutism Ovarian surgery for symptom relief in women with polycystic Menstrual ovarian syndrome (P) Disorders and Subfertility Group Hirsutism Interventions for hirsutism excluding laser and photoepilation Skin Group therapy (P)

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Skin Condition Review (R) or Protocol (P) Title Cochrane Group Rosacea Interventions for rosacea (R) Skin Group Hidradenitis Interventions for hidradenitis suppurativa (P) Skin Group suppurativa Eccrine sweat Interventions for excessive sweating of unknown cause (P) Skin Group disorder unspecified Vitiligo Interventions for vitiligo (R) Skin Group Chloasma Interventions for melasma (R) Skin Group Lichen Topical interventions for genital lichen sclerosus (R) Skin Group sclerosus Hypertrophic Silicone gel sheeting for preventing and treating hypertrophic and Wounds Group scar keloid scars (R) Lupus Drugs for discoid lupus erythematosus (R) Skin Group erythematosus Lupus Interventions for cutaneous disease in systemic lupus Skin Group erythematosus erythematosus (P) Localized Interventions for morphea (P) Skin Group scleroderma (morphea)

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eTable 5: Excluded titles generated from search of GBD 2010 “other skin and subcutaneous diseases” category in The Cochrane Database of Systematic Reviews

Searched Skin Review (R) or Protocol (P) Excluded Excluded Condition without after (ICD-10 code) Discrepancy Consensus Review Androgenic 5-alpha-reductase inhibitors for prostate X alopecia (L64) cancer prevention (R)

Hirustim Pre-operative endometrial thinning agents X (L68.0) before endometrial destruction for heavy menstrual bleeding (R)

Hirsutism Metformin treatment before and during IVF or X (L68.0) ICSI in women with polycystic ovary syndrome (R) Hirsutism Danazol for uterine fibroids (R) X (L68.0) Hirsutism Lifestyle changes in women with polycystic X (L68.0) ovary syndrome (R) Hirustism Quadriphasic versus monophasic oral X (L68.0) contraceptives for contraception (R) Hirsutism Acupuncture for polycystic ovarian syndrome X (L68.0) (R) Vitiligo (L80) Selenium supplementation for Hashimoto's X thyroiditis (R)

Lupus Dehydroepiandrosterone for systemic lupus X erythematosus erythematosus (R) (L93) Lupus Cyclophosphamide versus X erythematosus methylprednisolone for treating (L93) neuropsychiatric involvement in systemic lupus erythematosus (R) Lupus Treatment for lupus nephritis (R) X erythematosus (L93) Lupus Minocycline for acne vulgaris: efficacy and X erythematosus safety (R) (L93) Lupus Chloroquine as a steroid sparing agent for X erythematosus asthma (R) (L93) Lupus Cyclofenil for Raynaud's phenomenon in X erythematosus progressive systemic sclerosis (R) (L93) Lupus Ketanserin for Raynaud's phenomenon in X erythematosus progressive systemic sclerosis (R) (L93) Lupus Belimumab for systemic lupus erythematosus X erythematosus (P) (L93) Searched Skin Review (R) or Protocol (P) Excluded Excluded

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Condition without after (ICD-10 code) Discrepancy Consensus Review Lupus Disease modifying immunosuppressant drugs X erythematosus for juvenile-onset systemic lupus (L93) erythematosus (P) Lupus Herbal medicines for systemic lupus X erythematosus erythematosus (P) (L93)

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