The Anatomy and Physiology Learning System, 4Th Edition
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Development and Maintenance of Epidermal Stem Cells in Skin Adnexa
International Journal of Molecular Sciences Review Development and Maintenance of Epidermal Stem Cells in Skin Adnexa Jaroslav Mokry * and Rishikaysh Pisal Medical Faculty, Charles University, 500 03 Hradec Kralove, Czech Republic; [email protected] * Correspondence: [email protected] Received: 30 October 2020; Accepted: 18 December 2020; Published: 20 December 2020 Abstract: The skin surface is modified by numerous appendages. These structures arise from epithelial stem cells (SCs) through the induction of epidermal placodes as a result of local signalling interplay with mesenchymal cells based on the Wnt–(Dkk4)–Eda–Shh cascade. Slight modifications of the cascade, with the participation of antagonistic signalling, decide whether multipotent epidermal SCs develop in interfollicular epidermis, scales, hair/feather follicles, nails or skin glands. This review describes the roles of epidermal SCs in the development of skin adnexa and interfollicular epidermis, as well as their maintenance. Each skin structure arises from distinct pools of epidermal SCs that are harboured in specific but different niches that control SC behaviour. Such relationships explain differences in marker and gene expression patterns between particular SC subsets. The activity of well-compartmentalized epidermal SCs is orchestrated with that of other skin cells not only along the hair cycle but also in the course of skin regeneration following injury. This review highlights several membrane markers, cytoplasmic proteins and transcription factors associated with epidermal SCs. Keywords: stem cell; epidermal placode; skin adnexa; signalling; hair pigmentation; markers; keratins 1. Epidermal Stem Cells as Units of Development 1.1. Development of the Epidermis and Placode Formation The embryonic skin at very early stages of development is covered by a surface ectoderm that is a precursor to the epidermis and its multiple derivatives. -
Hair Histology As a Tool for Forensic Identification of Some Domestic Animal Species
EXCLI Journal 2018;17:663-670 – ISSN 1611-2156 Received: June 28, 2018, accepted: July 02, 2018, published: July 06, 2018 Original article: HAIR HISTOLOGY AS A TOOL FOR FORENSIC IDENTIFICATION OF SOME DOMESTIC ANIMAL SPECIES Yasser A. Ahmed1, Safwat Ali2, Ahmed Ghallab3* 1 Department of Histology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt 2 Department of Anatomy and Embryology, Faculty of Veterinary Medicine, Minia University, Minia, Egypt 3 Department of Forensic Medicine and Toxicology, Faculty of Veterinary Medicine, South Valley University, Qena, Egypt * Corresponding author: E-mail: [email protected] http://dx.doi.org/10.17179/excli2018-1478 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/). ABSTRACT Animal hair examination at a criminal scene may provide valuable information in forensic investigations. How- ever, local reference databases for animal hair identification are rare. In the present study, we provide differential histological analysis of hair of some domestic animals in Upper Egypt. For this purpose, guard hair of large rumi- nants (buffalo, camel and cow), small ruminants (sheep and goat), equine (horse and donkey) and canine (dog and cat) were collected and comparative analysis was performed by light microscopy. Based on the hair cuticle scale pattern, type and diameter of the medulla, and the pigmentation, characteristic differential features of each animal species were identified. The cuticle scale pattern was imbricate in all tested animals except in donkey, in which coronal scales were identified. The cuticle scale margin type, shape and the distance in between were characteristic for each animal species. -
Diapositiva 1
Ingegneria delle tecnologie per la salute Fondamenti di anatomia e istologia Apparato tegumentario aa. 2017-18 INTEGUMENTARY SYSTEM integumentary system = refers to skin and its accessory structures responsible for much more than simply human outward appearance: about 16% of body weight, covering an area of 1.5 to 2 m2 (= largest organ system in human body). • skin protects inner organs INTEGUMENTARY SYSTEM • skin = even not typical, but an organ, made of tissues that work together as a single structure to perform unique and critical functions • integumentary system = skin + its accessory structures, providing body with overall protection. • made of multiple layers of cells and tissues, which are held to underlying structures by connective tissue: deeper layer of skin is well vascularized (has numerous blood vessels) and also has numerous sensory, and autonomic and sympathetic nerve fibers ensuring communication to and from brain. INTEGUMENTARY SYSTEM Overview • Largest organ (15% of body weight) • Epidermis – keratinized stratified squamous epithelium • Dermis – connective tissue layer • Hypodermis • Thickness variable, normally 1-2 mm – dermis may thicken, up to 6 mm – stratum corneum layer increased • calluses on hands and feet Structure of the Skin 2 layers: epidermis + dermis SKIN: histology SKIN: histology SKIN: histology Cells of the Epidermis • Stem cells – undifferentiated cells in deepest layers • Keratinocytes – most of the skin cells • Melanocytes – synthesize pigment that shield UV • Tactile (merkel) cells – receptor cells associated with nerve fibers • Dendritic (langerhans) cells – macrophages guard against pathogens Cell and Layers of the Epidermis Epidermis: histology = composed of keratinized, stratified squamous epithelium, made of 4 or 5 layers of epithelial cells, depending on its location in body. -
Nail Anatomy and Physiology for the Clinician 1
Nail Anatomy and Physiology for the Clinician 1 The nails have several important uses, which are as they are produced and remain stored during easily appreciable when the nails are absent or growth. they lose their function. The most evident use of It is therefore important to know how the fi ngernails is to be an ornament of the hand, but healthy nail appears and how it is formed, in we must not underestimate other important func- order to detect signs of pathology and understand tions, such as the protective value of the nail plate their pathogenesis. against trauma to the underlying distal phalanx, its counterpressure effect to the pulp important for walking and for tactile sensation, the scratch- 1.1 Nail Anatomy ing function, and the importance of fi ngernails and Physiology for manipulation of small objects. The nails can also provide information about What we call “nail” is the nail plate, the fi nal part the person’s work, habits, and health status, as of the activity of 4 epithelia that proliferate and several well-known nail features are a clue to sys- differentiate in a specifi c manner, in order to form temic diseases. Abnormal nails due to biting or and protect a healthy nail plate [1 ]. The “nail onychotillomania give clues to the person’s emo- unit” (Fig. 1.1 ) is composed by: tional/psychiatric status. Nail samples are uti- • Nail matrix: responsible for nail plate production lized for forensic and toxicology analysis, as • Nail folds: responsible for protection of the several substances are deposited in the nail plate nail matrix Proximal nail fold Nail plate Fig. -
Pathologic Patterns of the Sebaceous Gland* John S
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by Elsevier - Publisher Connector PATHOLOGIC PATTERNS OF THE SEBACEOUS GLAND* JOHN S. STRAUSS, M.D.t AND ALBERT M. KLIGMAN, M.D. By studying the way in which a structurecells which subsequently rupture in the fundus reacts to an imposed experimental stress, oneof the gland. Fragments of the thin eosinophilie can often better understand the changes ex-cell wall, which morphologically resemble kera- hibited in spontaneous dlsease. Much has beentin, persist in the sebum; occasionally the entire learned about the potentialities of the eccrinecell walls survive as ghosts. Furthermore, the in- and apocrine sweat units in this fashion (1—12).dividual oil droplets are separated by keratin- Previous study of the response to injury in thelike trabeculae. A dual potentiality is exhibited sebaceous gland has been restricted mainly to theby sebaceous cells in their capacity to produce changes that occur in the sebaceous duct per sefat predominantly and keratin to a minor de- (13). In this study we have followed the reac-gree. Epidermal cells have this bipotentiality tion of the sebaceous gland itself to a variety ofwith keratin as the major product. cutaneous insults and have correlated the findings with those which occur in disease states. MA.TERIALS AND METRODS The scalp and cheek of post-puberal individuals MOBPOLOGY AND FUNCTION OF were selected for study because the glands here TRN SEACEOUS GLAND are among the largest and most numerous. Biopsy 1.Morphology: The glands of the glabrous skinspecimens were obtained before the experimental are not free but are associated with hair follicles,stresses as well as at varying intervals afterwards. -
Study Guide Medical Terminology by Thea Liza Batan About the Author
Study Guide Medical Terminology By Thea Liza Batan About the Author Thea Liza Batan earned a Master of Science in Nursing Administration in 2007 from Xavier University in Cincinnati, Ohio. She has worked as a staff nurse, nurse instructor, and level department head. She currently works as a simulation coordinator and a free- lance writer specializing in nursing and healthcare. All terms mentioned in this text that are known to be trademarks or service marks have been appropriately capitalized. Use of a term in this text shouldn’t be regarded as affecting the validity of any trademark or service mark. Copyright © 2017 by Penn Foster, Inc. All rights reserved. No part of the material protected by this copyright may be reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, or by any information storage and retrieval system, without permission in writing from the copyright owner. Requests for permission to make copies of any part of the work should be mailed to Copyright Permissions, Penn Foster, 925 Oak Street, Scranton, Pennsylvania 18515. Printed in the United States of America CONTENTS INSTRUCTIONS 1 READING ASSIGNMENTS 3 LESSON 1: THE FUNDAMENTALS OF MEDICAL TERMINOLOGY 5 LESSON 2: DIAGNOSIS, INTERVENTION, AND HUMAN BODY TERMS 28 LESSON 3: MUSCULOSKELETAL, CIRCULATORY, AND RESPIRATORY SYSTEM TERMS 44 LESSON 4: DIGESTIVE, URINARY, AND REPRODUCTIVE SYSTEM TERMS 69 LESSON 5: INTEGUMENTARY, NERVOUS, AND ENDOCRINE S YSTEM TERMS 96 SELF-CHECK ANSWERS 134 © PENN FOSTER, INC. 2017 MEDICAL TERMINOLOGY PAGE III Contents INSTRUCTIONS INTRODUCTION Welcome to your course on medical terminology. You’re taking this course because you’re most likely interested in pursuing a health and science career, which entails proficiencyincommunicatingwithhealthcareprofessionalssuchasphysicians,nurses, or dentists. -
CHAPTER 4 the Integumentary System
CHAPTER 4 The Integumentary System LEARNING OBJECTIVES Upon completion of this chapter, you should be able to: • Name the two layers of the skin. • Name the accessory structures of the integumentary system. • Build and pronounce medical terms of the integumentary system. • Name the disorders and treatments relating to the integumentary system. • Name the major classifi cations of pharmacologic agents used to treat skin disorders. • Analyze and defi ne the new terms introduced in this chapter. • Interpret abbreviations associated with the integumentary system. 53 54 PART TWO • BODY SYSTEMS Introduction The largest organ of the body is the skin. The skin covers the entire body—more than 20 square feet on average—and weighs about 24 pounds. It is part of the integumentary system, which also includes the accessory structures: hair, nails, and sebaceous (oil) and sudoriferous (sweat) glands. Integumentum is Latin for “covering” or “shelter.” The physician who specializes in the diag- nosis and treatment of skin disorders is called a dermatologist (dermat/o being one of the com- bining forms for skin). Coupling the root dermat/o with the previously learned suffi x -logy gives us the term dermatology , which is the term for the specialty practice that deals with the skin. Word Elements The major word elements that relate to the integumentary system consist of various anatomical components, accessory structures, colors of the skin, and abnormal conditions. The Word Ele- ments table lists many of the roots, their meanings, and examples associated -
Long-Lasting Muscle Thinning Induced by Infrared Irradiation Specialized with Wavelengths and Contact Cooling: a Preliminary Report
Long-Lasting Muscle Thinning Induced by Infrared Irradiation Specialized With Wavelengths and Contact Cooling: A Preliminary Report Yohei Tanaka, MD, Kiyoshi Matsuo, MD, PhD, and Shunsuke Yuzuriha, MD, PhD Department of Plastic and Reconstructive Surgery, Shinshu University School of Medicine, Matsumoto, Nagano 390-8621, Japan Correspondence: [email protected] Published May 28, 2010 Objective: Infrared (IR) irradiation specialized with wavelengths and contact cooling increases the amount of water in the dermis to protect the subcutaneous tissues against IR damage; thus, it is applied to smooth forehead wrinkles. However, this treatment consistently induces brow ptosis. Therefore, we investigated whether IR irradiation induces muscle thinning. Methods: Rat central back tissues were irradiated with the specialized IR device. Histological evaluation was performed on sagittal slices that included skin, panniculus carnosus, and deep muscles. Results: Significant reductions in panniculus carnosus thickness were observed between controls and irradiated tissues at postirradiation day 30 (P30), P60, P90, and P180; however, no reduction was observed in nonirradiated controls from days 0 to 180. No significant changes were observed in the trunk muscle over time. From day 0, dermal thickness was significantly reduced at P90 and P180; however, no difference was observed between P180 and nonirradiated controls at day 180. DNA degradation consistent with apoptosis was detected in the panniculus carnosus at P7 and P30. Conclusions: We found that IR irradiation induced long-lasting superficial muscle thinning, probably by a kind of apoptosis. The panniculus carnosus is equivalent to the superficial facial muscles of humans; thus, the changes observed here reflected those in the frontalis muscle that resulted in brow ptosis. -
Enabling Sweat-Based Biosensors: Solving the Problem of Low
Enabling sweat-based biosensors: Solving the problem of low biomarker concentration in sweat A dissertation submitted to the Graduate School of the University of Cincinnati in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Biomedical Engineering of the College of Engineering & Applied Science by Andrew J. Jajack B.S., Biology, Wittenberg University, 2014 Committee Chairs: Jason C. Heikenfeld, Ph.D. and Chia-Ying Lin, Ph.D. Abstract Non-invasive, sweat biosensing will enable the development of an entirely new class of wearable devices capable of assessing health on a minute-to-minute basis. Every aspect of healthcare stands to benefit: prevention (activity tracking, stress-level monitoring, over-exertion alerting, dehydration warning), diagnosis (early-detection, new diagnostic techniques), and management (glucose tracking, drug-dose monitoring). Currently, blood is the gold standard for measuring the level of most biomarkers in the body. Unlike blood, sweat can be measured outside of the body with little inconvenience. While some biomarkers are produced in the sweat gland itself, most are produced elsewhere and must diffuse into sweat. These biomarkers come directly from blood or interstitial fluid which surrounds the sweat gland. However, a two-cell thick epithelium acts as barrier and dilutes most biomarkers in sweat. As a result, many biomarkers that would be useful to monitor are diluted in sweat to concentrations below what can be detected by current biosensors. This is a core challenge that must be overcome before the advantages of sweat biosensing can be fully realized. The objective of this dissertation is to develop methods of concentrating biomarkers in sweat to bring them into range of available biosensors. -
Neural Control of Facial Sweat Gland Secretion in Horses
Iowa State University Capstones, Theses and Creative Components Dissertations Fall 2019 Neural control of facial sweat gland secretion in horses Lu Liu Follow this and additional works at: https://lib.dr.iastate.edu/creativecomponents Part of the Comparative and Evolutionary Physiology Commons, and the Systems and Integrative Physiology Commons Recommended Citation Liu, Lu, "Neural control of facial sweat gland secretion in horses" (2019). Creative Components. 455. https://lib.dr.iastate.edu/creativecomponents/455 This Creative Component is brought to you for free and open access by the Iowa State University Capstones, Theses and Dissertations at Iowa State University Digital Repository. It has been accepted for inclusion in Creative Components by an authorized administrator of Iowa State University Digital Repository. For more information, please contact [email protected]. Neural control of facial sweat gland secretion in horses Lu Liu 2019.11.26 BMS 599 Creative Component Biomedical Sciences Department Iowa State University Abstract: For sweat glands, it has been shown that sympathetic neurons express a cholinergic/noradrenergic co-phenotype in their innervation in the trunk of mice.(Schütz et al. 2008). It is unknown if facial sweat glands are innervated the same way. Gustatory sweating is an abnormal sweating condition. People can sweat profusely when eating or drinking, or even thinking about eating or drinking. We hypothesize that the facial sweat glands are controlled differently and can be related to parasympathetic neurons from cranial nerves. Some samples from human donors have been tested, but few sweat glands can be targeted since the donors were older people. Thus, it was decided to use horse tissue for this project to obtain greater numbers of sweat glands on the face. -
Biomechanics of Human Stratum Corneum: Dry Skin Conditions, Tissue Damage and Alleviation a Dissertation Submitted to the Depar
BIOMECHANICS OF HUMAN STRATUM CORNEUM: DRY SKIN CONDITIONS, TISSUE DAMAGE AND ALLEVIATION A DISSERTATION SUBMITTED TO THE DEPARTMENT OF MATERIALS SCIENCE AND ENGINEERING AND THE COMMITTEE ON GRADUATE STUDIES OF STANFORD UNIVERSITY IN PARTIAL FULFILLMENT OF THE REQUIREMENTS FOR THE DEGREE OF DOCTOR OF PHILOSOPHY Kemal Levi November 2009 © 2010 by Kemal Levi. All Rights Reserved. Re-distributed by Stanford University under license with the author. This work is licensed under a Creative Commons Attribution- Noncommercial 3.0 United States License. http://creativecommons.org/licenses/by-nc/3.0/us/ This dissertation is online at: http://purl.stanford.edu/cb644mw1707 ii I certify that I have read this dissertation and that, in my opinion, it is fully adequate in scope and quality as a dissertation for the degree of Doctor of Philosophy. Reinhold Dauskardt, Primary Adviser I certify that I have read this dissertation and that, in my opinion, it is fully adequate in scope and quality as a dissertation for the degree of Doctor of Philosophy. Sarah Heilshorn I certify that I have read this dissertation and that, in my opinion, it is fully adequate in scope and quality as a dissertation for the degree of Doctor of Philosophy. William Nix Approved for the Stanford University Committee on Graduate Studies. Patricia J. Gumport, Vice Provost Graduate Education This signature page was generated electronically upon submission of this dissertation in electronic format. An original signed hard copy of the signature page is on file in University Archives. iii Abstract The outermost layer of human skin, the stratum corneum (SC), is subject daily to variable ambient moisture and temperature conditions as well as application of potentially damaging cleansing agents. -
The Integumentary System
CHAPTER 5: THE INTEGUMENTARY SYSTEM Copyright © 2010 Pearson Education, Inc. OVERALL SKIN STRUCTURE 3 LAYERS Copyright © 2010 Pearson Education, Inc. Figure 5.1 Skin structure. Hair shaft Dermal papillae Epidermis Subpapillary vascular plexus Papillary layer Pore Appendages of skin Dermis Reticular • Eccrine sweat layer gland • Arrector pili muscle Hypodermis • Sebaceous (oil) gland (superficial fascia) • Hair follicle Nervous structures • Hair root • Sensory nerve fiber Cutaneous vascular • Pacinian corpuscle plexus • Hair follicle receptor Adipose tissue (root hair plexus) Copyright © 2010 Pearson Education, Inc. EPIDERMIS 4 (or 5) LAYERS Copyright © 2010 Pearson Education, Inc. Figure 5.2 The main structural features of the skin epidermis. Keratinocytes Stratum corneum Stratum granulosum Epidermal Stratum spinosum dendritic cell Tactile (Merkel) Stratum basale Dermis cell Sensory nerve ending (a) Dermis Desmosomes Melanocyte (b) Melanin granule Copyright © 2010 Pearson Education, Inc. DERMIS 2 LAYERS Copyright © 2010 Pearson Education, Inc. Figure 5.3 The two regions of the dermis. Dermis (b) Papillary layer of dermis, SEM (22,700x) (a) Light micrograph of thick skin identifying the extent of the dermis, (50x) (c) Reticular layer of dermis, SEM (38,500x) Copyright © 2010 Pearson Education, Inc. Figure 5.3a The two regions of the dermis. Dermis (a) Light micrograph of thick skin identifying the extent of the dermis, (50x) Copyright © 2010 Pearson Education, Inc. Q1: The type of gland which secretes its products onto a surface is an _______ gland. 1) Endocrine 2) Exocrine 3) Merocrine 4) Holocrine Copyright © 2010 Pearson Education, Inc. Q2: The embryonic tissue which gives rise to muscle and most connective tissue is… 1) Ectoderm 2) Endoderm 3) Mesoderm Copyright © 2010 Pearson Education, Inc.