Carlsberg Research Laboratory Annual Report
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Carlsberg Research Laboratory J. C. Jacobsens Gade 4 Carlsberg A/S 1799 Copenhagen V Denmark CARLSBERG RESEARCH LABORATORY ANNUAL REPORT 2020 SCIENTIFIC STAFF AT CARLSBERG RESEARCH LABORATORY Head of Carlsberg Research Laboratory, VP Group Research Birgitte Skadhauge Director of Research Support & Project Management Anders Holme Jensen Raw Materials platform Director Kim Jørgensen Professor (Associated) Geoff Fincher Principal Scientists Finn Lok, Kenneth Fredlund Senior Scientists Christoph Dockter, Pai Rosager Pedas Scientists and Postdocs Jose Cuesta-Seijo, Hanne Thomsen, Magnus Rasmussen, Qiongxian Lu, Emiko Murozuka, Katarzyna Braune, Lucia Marri, Júlía Hafþórsdóttir, Morten Jørgensen, Iain Cooper, Jeppe Opstrup Husum, Sophia Tulloch PhD students Martin Toft Simmelgård Nielsen Yeast & Fermentation platform Director Jochen Förster Senior Technical Brewer Birgitte Funch Senior Scientists Michael Katz, Claes Gjermansen, Rosa Garcia Sanchez, Klaus Lengeler Scientists and Postdocs Ross Fennessy, Vratislav Stovicek, Kim Friis Olsson, Anna Chailyan PhD students Isabella Jane Larsen New Ingredients platform Director Adam Fenton / Gustav Hambraeus Distinguished Professor (Associated) Birger Lindberg Møller Principal Scientists Pia Vaag Senior Scientists Ilka Braumann, Renil Manat, Jesper Harholt Scientists and Postdocs Oliver Kemp, Olayide Oladokun, Qing Liu, Brian King, Christian Poulsen, Andrea Delgado, Inês Oliveira, Kasper Nielsen 2 Brewing Science & Technology platform Director Zoran Gojkovic Head Brewer Erik Lund Principal Scientists Arvid Garde, Søren Knudsen Senior Scientists Jeppe Frank Andersen Scientists and Postdocs Michela Della Negra, Iuliana Stoica, Stefano Soprani, David Martinez, Ali Farsi, Yanyan Su, Rolf Ringborg, Ole Mikkelsen, Helena Friis, Kathrine Ørnslund PhD students Anders Bagger Sørensen Commercial Unit Director Gustav Hambraeus Senior Scientists Toni Wendt Scientists and Postdocs Jeppe Østerberg, Lillian Møller, Mikkel Jensen 3 *** PEER-REVIEWED PUBLICATIONS Betts, N.S., Collins, H.M., Shirley, N.J., Cuesta-Seijo, J.A., Schwerdt, J.G., Phillips, R.J., Finnie, C., Fincher, G.B., Dockter, C., Skadhauge, B., Bulone, V. (2020): Identification and spatio-temporal expression analysis of barley genes that encode putative modular xylanolytic enzymes. Plant Science, 110792. Betts, N.S., Dockter, C., Berkowitz, O., Collins, H.M., Hooi, M., Lu, Q.X., Burton, R.A., Bulone, V., Skadhauge, B., et al. (2020): Transcriptional and biochemical analyses of gibberellin expression and content in germinated barley grain. Journal of Experimental Botany, 71, 6, 1870-1884. Colomer, M.S., Chailyan, A., Fennessy, R.T., Olsson, K.F., Johnsen, L., Solodovnikova, N., Förster, J. (2020): Assessing Population Diversity of Brettanomyces Yeast Species and Identification of Strains for Brewing Applications. Frontiers in Microbiology, 11, 637. Colomer, M.S., Funch, B., Solodovnikova, N., Hobley, T.J., Förster, J. (2020): Biotransformation of hop derived compounds by Brettanomyces yeast strains. Journal of The Institute of Brewing, 126, 3, 280-288. Iaccarino, N., Khakimov, B., Mikkelsen, M.S., Nielsen, T.S., Jensen, M.G., Randazzo, A., Engelsen, S.B. (2020): Structurally different mixed linkage beta- glucan supplements differentially increase secondary bile acid excretion in hypercholesterolaemic rat faeces. Food & Function, 11, 1, 514-523. Knudsen, C., Bavishi, K., Viborg, K.M., Drew, D.P., Simonsen, H.T., Motawia, M.S., Møller, B.L., Laursen, T. (2020): Stabilization of dhurrin biosynthetic enzymes from Sorghum bicolor using a natural deep eutectic solvent. Phytochemistry, 170, 112214. Lengeler, Klaus B., Stovicek, V., Fennessy, R.T., Katz, M., Förster, J. (2020): Never Change a Brewing Yeast? Why Not, There Are Plenty to Choose From. Frontiers in Genetics, 11, 582789. Long, L.Z., Pedas, P.R., Kristensen, R.K., Schulze, W.X., Husted, S., Zhang, G.P., Schjoerring, J.K., Yuan, L.X. (2020): High light intensity aggravates latent manganese deficiency in maize. Journal of Experimental Botany, 17, 19, 6116- 6127. Lopez-Marques, R.L., Noerrevang, A.F., Ache, P., Moog, M., Visintainer, D., Wendt, T., Østerberg, J., Dockter, C., Jørgensen, M.E., et al. (2020): Prospects for the accelerated improvement of the resilient crop quinoa, Journal of Experimental Botany, 71, 18, 5333-5347. 4 Matyszczak, I., Tominska, M., Zakhrabekova, S., Dockter, C., Hansson, M. (2020): Analysis of early-flowering genes at barley chromosome 2H expands the repertoire of mutant alleles at the Mat-c locus. Plant Cell Reports, 39, 1, 47-61. Mnich, E., Bjarnholt, N., Eudes, A., Harholt, J., Holland, C., Jørgensen, B., Larsen, F.H., Liu, M., Manat, R., et al. (2020): Phenolic cross-links: building and de-constructing the plant cell wall. Natural Product Reports, 37, 7, 919-961. Xu, W.L., Jin, B., Zhou, S.F., Su, Y.Y., Zhang, Y.F. (2020): Triclosan Removal in Microbial Fuel Cell: The Contribution of Adsorption and Bioelectricity Generation. Energies, 13, 3, 761. Zhang, C.S., Kang, X.X., Wang, F.H., Tian, Y.F. Liu, T., Su, Y.Y., Qian, T.T., Zhang, Y.F. (2020): Valorization of food waste for cost-effective reducing sugar recovery in a two-stage enzymatic hydrolysis platform. Energy, 208, 118379. Zhao, N.N., Su, Y.Y., Angelidaki, I., Zhang, Y.F. (2020): Electrochemical capacitive performance of intact anaerobic granular sludge-based 3D bioanode. Journal of Power Sources, 470, 228399. Zhou, H.H., Xing, D.F., Xu, M.Y., Su, Y.Y., Zhang, Y.F. (2020): Biogas upgrading and energy storage via electromethanogenesis using intact anaerobic granular sludge as biocathode. Applied Energy, 269, 115101. *** MASTER THESES Cobo, M.F.: Brewery Wastewater Treatment and Nutrients Recovery by Microalgae, Technical University of Denmark (DTU), February 2020. Gómez, R.M.: Microalgae technology for brewery wastewater treatment, Technical University of Denmark (DTU), July 2020. Mattia, A.: Electrification of the heat supply in batch processes through heat pumps: Application in the brewery industry, Technical University of Denmark (DTU), July 2020. Mikkelsen, O.: Non-Saccharomyces yeast for beer brewing with special focus on usability of Yarrowia in the production of sour beer, University of Copenhagen (UCPH), July 2020. Thorball, N.A.: Co-cultivation of Hydrogen Oxidizing Bacteria and Microalgae for Brewery Wastewater Treatment, Technical University of Denmark (DTU), January 2020. 5 *** PUBLISHED PATENT APPLICATIONS AND GRANTED PATENTS Donaldson, I., Vaag, P., Gojkovic, Z.: Method for producing beverages by acid removal, Patent no.: 3434113 (European Patent). Møller, B., Mikkelsen, M., Jensen, M., Gojkovic, Z.: Beverages containing barley Beta-glucan, Patent no.: 3451852 (European Patent). Møller, B., Mikkelsen, M., Jensen, M., Gojkovic, Z.: Beverages containing barley Beta-glucan, Patent no.: 748105 (New Zealand). Riis, P., Knudsen, S., Skadhauge, B., Bech, L.M., Olsen, O.: A method for preparing a barley, a barley plant, a malt composition, and a barley based beverage prepared from a barley plant, Patent no.: 23028 (Vietnam). Riis, P., Knudsen, S., Skadhauge, B., Bech, L.M., Olsen, O.: Energy saving brewing method, Patent no.: BR 11 2012 030806-8 B1 (Brazil). Riis, P., Knudsen, S., Skadhauge, B., Bech, L.M., Olsen, O.: Energy saving brewing method, Patent no.: 344135 (India). Singh, S., Jakob, M.: Fermentation tank with side ports and method of operation, Patent no.: 036267 (Eurasian Patent). Singh, S., Jakob, M.: Fermentation tank with side ports and method of operation, Patent no.: 3452571 (European Patent). Solodovnikova, N., Andersen, J.F., Sanchez, R.G., Gojkovic, Z.: Yeast for preparing alcoholic beverages, Patent no.: 2015371749 (Australia). Solodovnikova, N., Andersen, J.F., Sanchez, R.G., Gojkovic, Z.: Yeast for preparing alcoholic beverages, Patent no.: 3237601 (European Patent). Sørensen, S.B., Breddam, K., Knudsen, S., Hambraeus, G., Bech, L.M., Skadhauge, B., Olsen, O.: Barley and malt-derived beverages with low DMS levels, Patent no.: 29621 (Egypt). Sørensen, S.B., Breddam, K., Knudsen, S., Hambraeus, G., Bech, L.M., Skadhauge, B., Olsen, O.: Barley and malt-derived beverages with low DMS levels, Patent no.: 32282 (Uruguay). Wendt, T., Krucewicz, K., Marri, L., Skadhauge, B., Lok, F., Knudsen, S., Olsen, O.: Refined Cereal-based Beverages, Patent no.: 3478813 (European Patent). Wendt, T., Krucewicz, K., Marri, L., Skadhauge, B., Lok, F., Knudsen, S., Olsen, O.: Refined Cereal-based Beverages, Patent no.: 19131 (OAPI). 6 Wendt, T., Krucewicz, K., Marri, L., Skadhauge, B., Lok, F., Knudsen, S., Olsen, O.: Refined Cereal-based Beverages, Patent no.: 11201810753S (Singapore). Wendt, T., Krucewicz, K., Marri, L., Skadhauge, B., Lok, F., Knudsen, S., Olsen, O.: Refined Cereal-based Beverages, Patent no.: 2018/08217, (South Africa). Wendt, T., Thomsen, H.C., Striebeck, A., Rasmussen, M.W., Carciofi, M., Olsen, O., Knudsen, S., Skadhauge, B.: Method of identifying a sub-pool comprising a mutant organism, Patent no.: 2019268102 (Australia). Wendt, T., Thomsen, H.C., Striebeck, A., Rasmussen, M.W., Carciofi, M., Olsen, O., Knudsen, S., Skadhauge, B.: Method of identifying a mutant plant, Patent no.: 2019268103 (Australia). Wendt, T., Thomsen, H.C., Striebeck, A., Rasmussen, M.W., Carciofi, M., Olsen, O., Knudsen, S., Skadhauge, B.: Method to screen for a mutant within a population of organisms by applying and pooling and splitting approach, Patent no.: 2018/08218 (South Africa). 7 .