Copyrighted Material
Total Page：16
File Type：pdf, Size：1020Kb
Load more
Recommended publications
-
Unusual Multiple Cutaneous Retiform Hemangioendothelioma on Forearm
Clinical and Diagnostic Pathology Research Article Unusual multiple cutaneous retiform hemangioendothelioma on forearm and neck misdiagnosed as angiosarcoma with metastasis Bin-cai Pan1, Chun-hua Wang1, Gui-fang Huang1, Xiao-ying Tian2 and Zhi Li3* 1Department of Pathology, Guangdong Tongjiang Hospital, Nanguo East Road, Shunde district, Foshan 528300, China 2School of Chinese Medicine, Hong Kong Baptist University 7, Baptist University Road, Kowloon Tong, Hong Kong, China 3Department of Pathology, The First Affiliated Hospital, Sun Yat-sen university.58, Zhongshan Road II,Guangzhou 510080, China Abstract Retiform hemangioendothelioma (RH) is extremely rare, and often involves the skin and subcutaneous tissues of distal extremities in young adults or children. Since its first description by Calonje in 1994, only a few primary multiple cases have been described in the literature. We present a case of unusual primary multiple RH on forearm and neck occurring in a 56 years old female patient. The patient presented with a slow-growing cutaneous plaque-like lesion on her left forearm, followed by another lesion at the site of neck for several years. In the skin biopsy examination, a diagnosis of angiosarcoma with cutaneous metastasis was made based on multiple lesions at different anatomic sites and vasoformative growth pattern with anastomosing channels under the microscopy. However, postoperative histological diagnosis of the lesion was primary multiple RH by thoroughly microscopical inspection and the presence of thin-walled interconnecting vascular channels arranged in a retiform pattern and absence of lymph node metastasis. Despite wide surgical excision with tumor-free margin, the tumor recurred at the neck 3 months after surgery. -
A Cutaneous Horn-Like Form of Juvenile Xanthogranuloma
Brief Report https://doi.org/10.5021/ad.2016.28.6.783 A Cutaneous Horn-Like Form of Juvenile Xanthogranuloma Young Hoon Yoon, Hyun Jeong Ju, Kyung Ho Lee, Chul Jong Park Department of Dermatology, Bucheon St. Mary’s Hospital, College of Medicine, The Catholic University of Korea, Bucheon, Korea Dear Editor: to be a cutaneous horn due to molluscum contagiosum or Juvenile xanthogranuloma (JXG) is a benign, self-healing, viral wart, and a shave biopsy was performed. non-Langerhans cell histiocytosis predominantly affecting Histopathologic examination revealed hyperkeratosis and infants and children. Usually, the clinical presentation is parakeratosis in the epidermis and dense intradermal his- characterized by solitary or multiple yellowish or red-brown tiocytic infiltrates, some of which contained foamy cells firm papules or nodules on the head, neck, and trunk1,2. and Touton giant cells (Fig. 2). Histopathological findings Herein, we report the case of a solitary JXG with an un- were consistent with a diagnosis of JXG. usual clinical presentation. JXG was first described by Adamson in 1905. Histological A 4-year-old boy presented with an asymptomatic nodule examination revealed an ill-defined, unencapsulated, on the left forearm since 2 months. The lesion was a dense histiocytic infiltration in the dermis. In mature le- corn-shaped, erythematous to yellowish nodule measuring sions, histiocytes have a foamy appearance, and Touton 0.5 cm in diameter and 0.7 cm in height. The apical part giant cells, which are characteristic of JXG, are observed. of the nodule showed marked hyperkeratosis (Fig. 1). The The clinical course tends to be benign, and lesions sponta- patient’s parents reported that it had spontaneously devel- neously regress over a period of months to years. -
Optimal Management of Common Acquired Melanocytic Nevi (Moles): Current Perspectives
Clinical, Cosmetic and Investigational Dermatology Dovepress open access to scientific and medical research Open Access Full Text Article REVIEW Optimal management of common acquired melanocytic nevi (moles): current perspectives Kabir Sardana Abstract: Although common acquired melanocytic nevi are largely benign, they are probably Payal Chakravarty one of the most common indications for cosmetic surgery encountered by dermatologists. With Khushbu Goel recent advances, noninvasive tools can largely determine the potential for malignancy, although they cannot supplant histology. Although surgical shave excision with its myriad modifications Department of Dermatology and STD, Maulana Azad Medical College and has been in vogue for decades, the lack of an adequate histological sample, the largely blind Lok Nayak Hospital, New Delhi, Delhi, nature of the procedure, and the possibility of recurrence are persisting issues. Pigment-specific India lasers were initially used in the Q-switched mode, which was based on the thermal relaxation time of the melanocyte (size 7 µm; 1 µsec), which is not the primary target in melanocytic nevus. The cluster of nevus cells (100 µm) probably lends itself to treatment with a millisecond laser rather than a nanosecond laser. Thus, normal mode pigment-specific lasers and pulsed ablative lasers (CO2/erbium [Er]:yttrium aluminum garnet [YAG]) are more suited to treat acquired melanocytic nevi. The complexities of treating this disorder can be overcome by following a structured approach by using lasers that achieve the appropriate depth to treat the three subtypes of nevi: junctional, compound, and dermal. Thus, junctional nevi respond to Q-switched/normal mode pigment lasers, where for the compound and dermal nevi, pulsed ablative laser (CO2/ Er:YAG) may be needed. -
WO 2016/176656 A2 3 November 2016 (03.11.2016) P O P C T
(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2016/176656 A2 3 November 2016 (03.11.2016) P O P C T (51) International Patent Classification: (74) Agent: BELLOWS, Brent, R.; Knowles Intellectual Prop A61K 39/00 (2006.01) erty Strategies, LLC, 400 Perimeter Center Terrace NE, Suite 200, Atlanta, GA 30346 (US). (21) International Application Number: PCT/US20 16/030303 (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, (22) International Filing Date: AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, 29 April 2016 (29.04.2016) BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, (25) Filing Language: English DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, (26) Publication Language: English KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, (30) Priority Data: MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, 62/155,217 30 April 2015 (30.04.2015) US PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, 62/232,148 24 September 2015 (24.09.2015) US SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, 62/268,257 16 December 201 5 (16. 12.2015) us TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. -
Precancerous Diseases of Maxillofacial Area
PRECANCEROUS DISEASES OF MAXILLOFACIAL AREA Text book Poltava – 2017 0 МІНІСТЕРСТВО ОХОРОНИ ЗДОРОВ’Я УКРАЇНИ ВИЩИЙ ДЕРЖАВНИЙ НАВЧАЛЬНИЙ ЗАКЛАД УКРАЇНИ «УКРАЇНСЬКА МЕДИЧНА СТОМАТОЛОГІЧНА АКАДЕМІЯ» АВЕТІКОВ Д.С., АЙПЕРТ В.В., ЛОКЕС К.П. AVETIKOV D.S., AIPERT V.V., LOKES K.P. Precancerous diseases of maxillofacial area ПЕРЕДРАКОВІ ЗАХВОРЮВАННЯ ЩЕЛЕПНО-ЛИЦЕВОЇ ДІЛЯНКИ Навчальний посібник Text-book Полтава – 2017 Poltava – 2017 1 UDK 616.31-006 BBC 56.6 A 19 It is recommended by the Academic Council of the Higher state educational establishment of Ukraine "Ukrainian medical stomatological academy" as a textbook for English-speaking students of higher education institutions of the Ministry of Health of Ukraine (Protocol № 3, 22.11.2017). Writing Committee D.S. Avetikov – doctor of medicsl science, professor, chief of department of surgical stomatology and maxillo-facial surgery with plastic and reconstructive surgery of head and neck of the Higher state educational establishment of Ukraine ―Ukrainian medical stomatological academy‖. V.V. Aipert – candidate of medical science, assistant professor of department of surgical stomatology and maxillo-facial surgery with plastic and reconstructive surgery of head and neck of the Higher state educational establishment of Ukraine ―Ukrainian medical stomatological academy‖ K.P. Lokes - candidate of medical science, associate professor of department of surgical stomatology and maxillo-facial surgery with plastic and reconstructive surgery of head and neck of the Higher state educational establishment of Ukraine ―Ukrainian medical stomatological academy‖ Reviewers: R. Z. Ogonovski, doctor of medicsl science, professor, chief of department of surgical stomatology and maxillo-facial surgery ―Lviv national medical university named of D.Galicky‖. Y.P. -
Dermatopathology
Dermatopathology Clay Cockerell • Martin C. Mihm Jr. • Brian J. Hall Cary Chisholm • Chad Jessup • Margaret Merola With contributions from: Jerad M. Gardner • Talley Whang Dermatopathology Clinicopathological Correlations Clay Cockerell Cary Chisholm Department of Dermatology Department of Pathology and Dermatopathology University of Texas Southwestern Medical Center Central Texas Pathology Laboratory Dallas , TX Waco , TX USA USA Martin C. Mihm Jr. Chad Jessup Department of Dermatology Department of Dermatology Brigham and Women’s Hospital Tufts Medical Center Boston , MA Boston , MA USA USA Brian J. Hall Margaret Merola Department of Dermatology Department of Pathology University of Texas Southwestern Medical Center Brigham and Women’s Hospital Dallas , TX Boston , MA USA USA With contributions from: Jerad M. Gardner Talley Whang Department of Pathology and Dermatology Harvard Vanguard Medical Associates University of Arkansas for Medical Sciences Boston, MA Little Rock, AR USA USA ISBN 978-1-4471-5447-1 ISBN 978-1-4471-5448-8 (eBook) DOI 10.1007/978-1-4471-5448-8 Springer London Heidelberg New York Dordrecht Library of Congress Control Number: 2013956345 © Springer-Verlag London 2014 This work is subject to copyright. All rights are reserved by the Publisher, whether the whole or part of the material is concerned, specifi cally the rights of translation, reprinting, reuse of illustrations, recitation, broadcasting, reproduction on microfi lms or in any other physical way, and transmission or information storage and retrieval, electronic adaptation, computer software, or by similar or dissimilar methodology now known or hereafter developed. Exempted from this legal reservation are brief excerpts in connection with reviews or scholarly analysis or material supplied specifi cally for the purpose of being entered and executed on a computer system, for exclusive use by the purchaser of the work. -
Cutaneous Horn: a Potentially Malignant Entity
Letter to the editor Cutaneous horn: a potentially malignant entity Cutaneous horn: a potentially malignant entity N. F. Fernandes, S. Sinha, W. C. Lambert, and R. A. Schwartz S UMMARY A cutaneous horn is a conical, dense, hyperkeratotic protrusion that often appears similar to the horn of an animal. It is a morphologic designation referring to an unusually cohesive keratinized material, not a true pathologic diagnosis. Cutaneous horns occur in association with, or as a re- sponse to, a wide variety of underlying benign, pre-malignant, and malignant cutaneous diseases. The most important common concern is distinguishing a hyperkeratotic actinic keratosis from a cutaneous squamous cell carcinoma. Keratoacanthoma is another cause, as illustrated herein as a projective cutaneous tumor with a fingernail-like appearance. The treatment of choice for cuta- neous horns is shave excision with subsequent histopathologic evaluation to rule out underlying malignancy and to guide potential further therapy. KEYIntroduction with the characterization of cutaneous horns as a WORDS medical disorder in the late eighteenth century (2). A cutaneous horn is a conical, dense hyperkeratotic cutaneous protrusion that often resembles the horn of an Epidemiology and etiology horn, cornu animal. The earliest documented case of cutaneous cutaneum, horn, or cornu cutaneum, was that of an elderly Welsh Cutaneous horns are nodules composed of hyperkerato- woman in London who was displayed commercially compact keratin that project above the surface of sis, actinic as an anomaly of nature in 1588 (1). There were the skin. They differ from animal horns by the keratosis, several other accounts of cutaneous horns in the absence of a central bone. -
Just a Cutaneous (Keratotic) Horn?
BMJ 2019;364:l595 doi: 10.1136/bmj.l595 (Published 7 March 2019) Page 1 of 2 Endgames BMJ: first published as 10.1136/bmj.l595 on 7 March 2019. Downloaded from ENDGAMES SPOT DIAGNOSIS Just a cutaneous (keratotic) horn? Jane Wilcock general practitioner, Yvonne Savage Silverdale Medical Practice, Salford, Manchester, UK A 70 year old woman attended a dermatologist with a lesion on In this case, the speed of growth made a keratoacanthoma a the dorsum of her right hand (fig 1). It had appeared over eight possibility. However, the patient also had several risk factors weeks and was painless but unsightly. She reported good health for squamous cell cancer: age, sun exposure, past lymphoma,1 and no history of warts. Fifteen years ago, she had lymphoma past chemotherapy, and no history of warts. Other invasive treated by chemotherapy; her last treatment (biological therapy) features of squamous cell cancer relevant to this case include had finished seven years ago and she had been well since. She the lesion’s arrival over eight weeks and its wide, thick, red base had holidayed in Australia for three months at a time over the with a diameter larger than the height of the horn. About 35% 2 last three years and more recently had driven frequently from of keratotic horns are invasive squamous cell cancers. http://www.bmj.com/ northern England to the south coast while a close relative was Invasive squamous cell cancer is a non-melanotic skin ill. She said she was careful to use sunscreen. malignancy with a good prognosis but may metastasise to the lymph nodes. -
(C) Mosby-Year Book Inc. 1996. All Rights Reserved
The Journal of Pediatrics (C) Mosby-Year Book Inc. 1996. All Rights Reserved. ---------------------------------------------- Volume 128(3) March 1996 pp 329-335 ---------------------------------------------- Congenital hemangioma: Evidence of accelerated involution [Original Article] Boon, Laurence M. MD; Enjolras, Odile MD; Mulliken, John B. MD From the Division of Plastic Surgery, Children's Hospital and Harvard Medical School, Boston, Massachusetts, and the Department of Dermatology, Hopital Tarnier-Cochin, Paris, France. Submitted for publication Sept. 8, 1995; accepted Nov. 28, 1995. Reprint requests: John B. Mulliken, MD, Division of Plastic Surgery, Children's Hospital, 300 Longwood Ave., Boston, MA 02115. ---------------------------------------------- Outline Abstract METHODS RESULTS DISCUSSION REFERENCES Graphics Figure 1 Figure 2 Figure 3 Figure 4 Figure 5 ---------------------------------------------- Abstract Objective: To study the course of hemangiomas that proliferate in utero, are fully grown at birth, and begin to regress during early infancy. Design: We analyzed retrospectively 31 infants with congenital hemangioma seen at Tarnier-Cochin Hospital (Paris) and Children's Hospital (Boston). Diagnosis was made by clinical and radiologic examination and, if necessary, by biopsy. Age, gender, location, appearance, and evolution were noted for each infant. : Only 3 of 23 congenital hemangiomas were diagnosed in utero by ultra- sonography. The three most common morphologic forms were raised violaceous tumor with ectatic veins (n = 8), raised grayish tumor with multiple tiny telangiectasias, surrounded by a pale halo (n = 8), and flat infiltrative tumor with violaceous overlying skin (n = 5). Two congenital hemangiomas had associated thrombocytopenic coagulopathy (Kasabach-Merritt phenomenon). All the untreated congenital hemangiomas (n = 24) regressed by the time the infants were 14 months of age, leaving either atrophic skin or extra skin. -
Inflammatory Juvenile Compound Conjunctival Nevi. a Clinicopathological Study and Literature Review
Rom J Morphol Embryol 2017, 58(3):in press R J M E EVIEW AND ASE ERIES Romanian Journal of R C S Morphology & Embryology http://www.rjme.ro/ Inflammatory juvenile compound conjunctival nevi. A clinicopathological study and literature review CLAUDIA FLORIDA COSTEA1,2), MIHAELA DANA TURLIUC3,4), GABRIELA DIMITRIU2), CAMELIA MARGARETA BOGDĂNICI1), ANCA MOŢOC2), MĂDĂLINA ADRIANA CHIHAIA2), CRISTINA DANCĂ2), ANDREI CUCU4), ALEXANDRU CĂRĂULEANU5), NICOLETA DUMITRESCU6), LUCIA INDREI7), ŞERBAN TURLIUC8) 1)Department of Ophthalmology, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania 2)2nd Ophthalmology Clinic, “Prof. Dr. Nicolae Oblu” Emergency Clinical Hospital, Iaşi, Romania 3)Department of Neurosurgery, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania 4)2nd Neurosurgery Clinic, “Prof. Dr. Nicolae Oblu” Emergency Clinical Hospital, Iaşi, Romania 5)Department of Obstetrics and Gynecology, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania 6)4th Year Student, Faculty of Medicine, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania 7)3rd Year Student, Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania 8)Department of Psychiatry, “Grigore T. Popa” University of Medicine and Pharmacy, Iaşi, Romania Abstract Aim: The conjunctival nevus affecting children and adolescents is a rare condition and the literature showed only few reports on this issue. The aim of this article is to determine the histopathological features for the correct diagnosis of an inflammatory juvenile compound nevus of the conjunctiva (IJCNC) in order to make the difference between this tumor and other lesions, like conjunctival melanoma or lymphoma, very similar from a gross point of view. -
Table of Contents
CONTENTS 1. Specimen evaluation 1 Specimen Type. 1 Clinical History. 1 Radiologic Correlation . 1 Special Studies . 1 Immunohistochemistry . 2 Electron Microscopy. 2 Genetics. 3 Recognizing Non-Soft Tissue Tumors. 3 Grading and Prognostication of Sarcomas. 3 Management of Specimen and Reporting. 4 2. Nonmalignant Fibroblastic and Myofibroblastic Tumors and Tumor-Like Lesions . 7 Nodular Fasciitis . 7 Proliferative Fasciitis and Myositis . 12 Ischemic Fasciitis . 18 Fibroma of Tendon Sheath. 21 Nuchal-Type Fibroma . 24 Gardner-Associated Fibroma. 27 Desmoplastic Fibroblastoma. 27 Elastofibroma. 34 Pleomorphic Fibroma of Skin. 39 Intranodal (Palisaded) Myofibroblastoma. 39 Other Fibroma Variants and Fibrous Proliferations . 44 Calcifying Fibrous (Pseudo)Tumor . 47 Juvenile Hyaline Fibromatosis. 52 Fibromatosis Colli. 54 Infantile Digital Fibroma/Fibromatosis. 58 Calcifying Aponeurotic Fibroma. 63 Fibrous Hamartoma of Infancy . 65 Myofibroma/Myofibromatosis . 69 Palmar/Plantar Fibromatosis. 80 Lipofibromatosis. 85 Diffuse Infantile Fibromatosis. 90 Desmoid-Type Fibromatosis . 92 Benign Fibrous Histiocytoma (Dermatofibroma). 98 xi Tumors of the Soft Tissues Non-neural Granular Cell Tumor. 104 Neurothekeoma . 104 Plexiform Fibrohistiocytic Tumor. 110 Superficial Acral Fibromyxoma . 113 Superficial Angiomyxoma (Cutaneous Myxoma). 118 Intramuscular Myxoma. 125 Juxta-articular Myxoma. 128 Aggressive Angiomyxoma . 128 Angiomyofibroblastoma. 135 Cellular Angiofibroma. 136 3. Fibroblastic/Myofibroblastic Neoplasms with Variable Biologic Potential. -
Toma, 539 Acinic Cell Carcinoma Mucinous Adenocarcinoma Vs., 334
Cambridge University Press 978-0-521-87999-6 - Head and Neck Margaret Brandwein-Gensler Index More information INDEX acanthomatous/desmoplastic ameloblas- ameloblastomas benign neoplasia toma, 539 desmoplastic ameloblastoma, 539 juvenile nasopharyngeal angiofibroma, acinic cell carcinoma metastasizing ameloblastoma, 537 99–104 mucinous adenocarcinoma vs., 334–335 mural ameloblastoma, 533 salivary gland anlage tumor, 104–106 oncocytoma vs., 295–299 odonto-ameloblastoma, 551–553 benign peripheral nerve sheath tumors papillary cystic variant, vs. cystade- peripheral ameloblastoma, 534 (BPNST), 40–44 noma, 316–317 unicystic ameloblastoma, 532–533 benign sinonasal tract neoplasia, 28–48 salivary glands, 353–359 aneurysmal bone cyst (ABC), 584 benign peripheral nerve sheath tumor, adenocarcinoma not otherwise specified central GCRG vs., 590–591 40–44 (ANOS), 389–390 angiocentric T-cell lymphoma, 81 meningioma, 37–40 adenoid cystic carcinoma (ACC) angiomatoid/angioectatic polyps vs. JNAF, nasal glial heterotopia (NGH), 44–48 adenomatoid odontogenic tumor vs., 100–104 oncocytic Schneiderian papilloma 545 angiosarcoma vs. Kaposi’s sarcoma, 206 (OSP), 5, 33–36 basal cell adenocarcinoma vs., 372 antrochoanal polyp, 5–8 Schneiderian inverted papilloma, 28–32 basal cell adenoma vs., 293 apical periodontal cyst, 510–512 bisphosphonate osteonecrosis (BPP), canalicular adenoma vs., 294 arytenoid chondrosarcomas, 241 565–566 neuroendocrine carcinoma vs., 240–241 atrophic oral lichen planus, 126 blastomas of salivary glands, 319–325 atypical adenoma vs. parathyroid