DXS 100 Gephyrocapsa oceanica RCC1303 100 Emiliania huxleyi 64 Isochrysis galbana CCMP1323 Chyrsochromulina ericina CCMP281 70 100 Prymnesium parvum_Texoma1 haptophytes 98 Phaeocystis sp CCMP2710 63 Karlodinium micrum CCMP2283 76 Pavlova sp. CCMP459 Eutreptiella gymnastica NIES-381 euglenid Nannochloropsis gaditana stramenopile 87 Chromera velia CCMP2878 Vitrella brassicaformis CCMP3155 chromerids 88 60 Toxoplasma gondii apicomplexan parasite

Voromonas pontica colpodellid 72 Thalassiosira pseudonana 99 Odontella aurita isolate 1302-5 84 Phaeodactylum tricornutum stramenopiles

56 Heterosigma akashiwo CCMP 452 96 71 Guillardia theta 100 Rhodomonas lens RHODO cryptophytes Hemiselmis andersenii CCMP644 Aureococcus anophagefferens CCMP1850 stramenopile 55 Porphyridium aerugineum SAG 1380-2 61 Chondrus crispus Rhodosorus marinus CCMP 769 72 red algae Cyanidioschyzon merolae 92 Galdieria sulphuraria Symbiodinium sp. CCMP2430 Polarella glacialis CCMP 1383 Peridinium aciculiferum PAER-2 90 Heterocapsa rotundata SCCAP K-0483 94 Lingulodinium polyedrum CCMP 1738 dinoflagellates 100 Lepidodinium chlorophorum NIES-1868 88 Lepidodinium chlorophorum NIES-1868 73 90 Amphidinium carterae CCMP1314 100 Karenia brevis_Wilson Gloeochaete witrockiana SAG 46.84 glaucophyte 100 Chlamydomonas reinhardtii 96 Volvox carteri f. nagariensis Chlorella variabilis 92 Bigelowiella natans CCMP 2755 100 Lotharella globosa LEX01 chlorarachniophytes Chlorarachnion reptans CCCM449 green plants 100 Ostreococcus tauri 93 Micromonas sp. RCC299 99 Arabidopsis thaliana Oryza sativa japonica 100 Selaginella moellendorffii Physcomitrella patens subsp. patens 64 Synechocystis sp. PCC 6803 Microcystis aeruginosa Trichodesmium erythraeum 100 Anabaena variabilis Nostoc sp. PCC 7120 cyanobacteria Synechococcus sp. WH8102 Thermosynechococcus sp. NK55 Acaryochloris marina

0.2 0.4 DXR 51 Lepidodinium chlorophorum NIES-1868 Gymnodinium catenatum GC744 97 Karlodinium micrum CCMP2283 Karenia brevis_Wilson Lepidodinium chlorophorum NIES-1868 dinoflagellates Peridinium aciculiferum PAER-2 Lingulodinium polyedrum CCMP 1738 100 Heterocapsa rotundata SCCAP K-0483 76 Symbiodinium sp. CCMP421 Oxyrrhis marina Perkinsus marinus ATCC 50439 perkinsid 100 Theileria orientalis 100 Babesia equi apicomplexan 87 Plasmodium falciparum 3D7 parasites Toxoplasma gondii 100 Emiliania huxleyi Gephyrocapsa oceanica RCC1303 Isochrysis galbana CCMP 1323 Coccolithus pelagicus ssp braarudi PLY182g haptophytes 100 Phaeocystis sp CCMP2710

87 Pavlova sp. CCMP459 58 Prymnesium parvum_Texoma1

70 Aureococcus anophagefferens 100 Hemiselmis andersenii CCMP644 Guillardia theta cryptophytes

78 100 Phaeodactylum tricornutum Thalassiosira pseudonana 81 Ochromonas sp CCMP1899 stramenopiles 65 Ectocarpus siliculosus Bigelowiella natans CCMP 2755 100 Chlorarachnion reptans CCCM449 chlorarachniophytes Lotharella globosa LEX01 70 Chromera velia CCMP2878 Vitrella brassicaformis CCMP3155 chromerids Eutreptiella gymnastica NIES-381 euglenid 75 Chondrus crispus Rhodosorus marinus CCMP 769 Cyanidioschyzon merolae red algae Galdieria sulphuraria 70 Prochlorococcus marinus SS120 100 Synechococcus sp. WH8102 cyanobacteria cyanelle in Paulinella chromatophora 100 Ostreococcus tauri 82 Micromonas sp. RCC299 100 Chlamydomonas reinhardtii 100 Volvox carteri f. nagariensis green plants 65 Arabidopsis thaliana 97 Physcomitrella patens subsp. patens Selaginella moellendorffii 80 Synechocystis sp. PCC 6803 Acaryochloris marina 86 Trichodesmium erythraeum cyanobacteria 73 100 Nostoc sp. PCC 7120 Anabaena variabilis Gloeochaete wittrockiana SAG4.46.84 glaucophyte

0.2 0.4 IspD 53 Isochrysis galbana CCMP1323 Coccolithus pelagicus ssp braarudi PLY182g 100 Prymnesium parvum_Texoma1 59 Chrysochromulina polylepis CCMP1757 92 Phaeocystis antarctica haptophytes 24 Gephyrocapsa oceanica RCC1303 Emiliania huxleyi Pavlova sp. CCMP459

Cyanidioschyzon merolae red alga Vaucheria litorea CCMP2940 Phaeodactylum tricornutum 53 Leptocylindrus danicus var. apora B651 100 Odontella aurita isolate 1302-5 88 Thalassiosira pseudonana strameno- Chromera velia CCMP2878 chromerid piles Chattonella subsalsa CCMP2191 Aureococcus anophagefferens

100 Ochromonas sp CCMP1899 Lepidodinium chlorophorum NIES-1868 63 Guillardia theta Hemiselmis andersenii CCMP644 cryptophytes

Vitrella brassicaformis CCMP3155 chromerid 80 83 Rhodella maculata CCMP 736 Rhodosorus marinus UTEX LB 2760 Ectocarpus siliculosus red algae Galdieria sulphuraria Gloeochaete witrockiana SAG 46.84 glaucophyte

88 Lotharella globosa LEX01 chlorarachniophytes 77 Bigelowiella natans CCMP 2755 93 Eutreptiella cf. gymnastica CCMP1594 euglenid 99 Chlamydomonas reinhardtii Volvox carteri f. nagariensis

82 Ostreococcus lucimarinus Micromonas sp. RCC299 green plants Pyramimonas parkeae CCMP726

22 Karenia brevis CCMP2229 68 Selaginella moellendorffii 67 Physcomitrella patens subsp. patens Arabidopsis thaliana Perkinsus marinus ATCC 50439 perkinsid 64 Symbiodinium sp. CCMP421 53 Protoceratium reticulatum CCCM 535 (=CCMP 1889) Polarella glacialis CCMP 1383 Lepidodinium chlorophorum NIES-1868 dinoflagellates 56 Heterocapsa rotundata SCCAP K-0483 Peridinium aciculiferum PAER-2 81 Lingulodinium polyedrum CCMP 1738 Karlodinium micrum CCMP2283 Theileria orientalis apicomplexan parasite

97 Anabaena variabilis Nostoc sp. PCC 7120 Trichodesmium erythraeum Synechocystis sp. PCC 6803 83 50 Microcystis aeruginosa cyanobacteria 100 Acaryochloris marina 52 Prochlorococcus marinus SS120 95 Synechococcus sp. WH8102 cyanelle in Paulinella chromatophora

0.2 0.4 100 Emiliania huxleyi 99 Gephyrocapsa oceanica RCC1303 IspE 93 Isochrysis galbana CCMP 1323 66 Coccolithus pelagicus ssp braarudi PLY182g haptophytes 100 99 Chrysochromulina polylepis CCMP1757 Prymnesium parvum_Texoma1 51 Karenia brevis 83 Hemiselmis rufescens PCC563 100 Guillardia theta CCMP 2712 cryptophytes Rhodomonas lens RHODO 71 Physcomitrella patens 100 Selaginella moellendorffii 69 Arabidopsis thaliana Pyramimonas parkeae CCMP726 green plants 100 81 Chlamydomonas reinhardtii Coccomyxa subellipsoidea 77 Micromonas sp. RCC299 Ostreococcus lucimarinus 87 Phaeodactylum tricornutum 96 Thalassiosira pseudonana Odontella sinensis_Odontella sinensis (Grunow) 1884 Aureococcus anophagefferens CCMP1850 stramenopiles Nannochloropsis gaditana Chattonella subsalsa CCMP2191 Lotharella globosa LEX01 72 Chlorarachnion reptans CCCM449 88 Bigelowiella natans CCMP 2755 chlorarachniophytes Gymnochlora sp. CCMP2014 Eutreptiella gymnastica NIES-381 euglenid Gloeochaete wittrockiana SAG4.46.84 glaucophyte

Chondrus crispus red alga 71 Lepidodinium chlorophorum 95 Gymnodinium catenatum GC744 Lepidodinium chlorophorum NIES-1868 Karlodinium micrum Karenia brevis Lingulodinium polyedrum CCMP 1738 dinoflagellates 55 Amphidinium carterae CCMP1314 Prorocentrum minium CCMP2233 88 Polarella glacialis CCMP 1383 Peridinium aciculiferum PAER-2 Symbiodinium sp. CCMP2430

53 Voromonas pontica colpodellid 74 Vitrella brassicaformis CCMP3155 Chromera velia CCMP2878 chromerids

70 Plasmodium falciparum 3D7 apicomplexan parasite Galdieria sulphuraria Cyanidioschyzon merolae red algae 99 Nostoc sp. PCC 7120 75 Anabaena variabilis 88 Trichodesmium erythraeum 96 Oscillatoria acuminata cyanobacteria 100 Synechocystis sp. PCC 6803 100 Prochlorococcus marinus SS120 Synechococcus sp. WH8102

0.2 0.4 Chrysochromulina polylepis CCMP1757 Coccolithus pelagicus ssp braarudi PLY182g Karenia brevis CCMP2229 IspF 100 Emiliania huxleyi haptophytes 70 Gephyrocapsa oceanica RCC1303 93 Isochrysis sp. CCMP1324 Prymnesium parvum_Texoma1 Aureococcus anophagefferens Ochromonas sp. CCMP1393 70 stramenopiles Ectocarpus siliculosus 53 Heterocapsa rotundata SCCAP K-0483 56 Peridinium aciculiferum PAER-2 59 Karenia brevis_Wilson dinoflagellates 85 63 Lepidodinium chlorophorum NIES-1868 Togula jolla CCCM 725 Karlodinium micrum CCMP2283 82 Phaeodactylum tricornutum Kryptoperidinium foliaceum CCMP 1326 98 stramenopiles Thalassiosira pseudonana Durinskia baltica CSIRO CS-38 96 Vitrella brassicaformis CCMP3155 Chromera velia CCMP2878 chromerids Gymnodinium catenatum GC744 64 Lepidodinium chlorophorum NIES-1868 94 Symbiodinium sp. CCMP2430 Polarella glacialis CCMP 1383 60 Eutreptiella cf. gymnastica CCMP1594 euglenid dinoflagellates 91 Alexandrium minutum CCMP113 Lingulodinium polyedrum CCMP 1738 68 51 Guillardia theta Rhodomonas lens RHODO cryptophytes Hemiselmis andersenii CCMP644 59 Gymnochlora sp. CCMP2014 85 Chlorarachnion reptans CCCM449 chlorarachniophytes 66 Lotharella globosa LEX01 Nannochloropsis gaditana stramenopile Plasmodium falciparum 3D7 apicomplexan parasite Cyanidioschyzon merolae Chondrus crispus Rhodosorus marinus CCMP 769 red algae Gloeochaete wittrockiana SAG4.46.84 glaucophyte 75 Galdieria sulphuraria 99 Micromonas sp. RCC299 Ostreococcus tauri 59 99 Volvox carteri f. nagariensis 91 Chlamydomonas reinhardtii 66 Chlorella variabilis 82 green plants 82 Physcomitrella patens subsp. 91 Selaginella moellendorffii Oryza sativa japonica 80 Arabidopsis thaliana Theileria parva Toxoplasma gondii apicomplexan parasites 99 Nostoc sp. PCC 7120 Anabaena variabilis Acaryochloris marina Trichodesmium erythraeum Thermosynechococcus elongatus cyanobacteria 84 Oscillatoria acuminata Microcystis aeruginosa Synechocystis sp. PCC 6803 99 Synechococcus sp. WH8102 cyanelle in Paulinella chromatophora

0.5 100 Emiliania huxleyi Emiliania huxleyi IspG 83 Chyrsochromulina ericina CCMP281 100 Prymnesium parvum_Texoma1 haptophytes 98 Isochrysis galbana CCMP1323

100 Emiliania huxleyi Thalassiosira pseudonana Phaeodactylum tricornutum stramenopiles Durinskia baltica CSIRO CS-38 Bigelowiella natans CCMP1258.1 chlorarachniophyte 99 Plasmodium falciparum 3D7 94 Theileria annulata apicomplexan Toxoplasma gondii parasites 77 55 Chromera velia CCMP2878 68 Vitrella brassicaformis CCMP3155 chromerids Voromonas pontica colpodellid Ochromonas sp. BG-1 Heterosigma akashiwo NB stramenopiles 100 Volvox carteri f. nagariensis 99 Chlamydomonas reinhardtii Chlorella variabilis 99 Arabidopsis thaliana green plants 89 Oryza sativa japonica 100 Selaginella moellendorffii Physcomitrella patens subsp. patens 68 Cryptomonas curvata CCAP979/52 71 54 Hemiselmis andersenii CCMP441 100 Guillardia theta cryptophytes Rhodomonas salina CCMP1319 95 100 Micromonas sp. RCC299 Ostreococcus tauri green plants Eutreptiella gymnastica NIES-381 euglenid Symbiodinium sp. CCMP421 Alexandrium catenella OF101 Lingulodinium polyedrum CCMP 1738 Durinskia baltica CSIRO CS-38 52 Lepidodinium chlorophorum NIES-1868 dinoflagellates 82 Karenia brevis CCMP2229 98 Karlodinium micrum CCMP2283 Lepidodinium chlorophorum NIES-1868 Rhodella maculata CCMP 736 51 Chondrus crispus 94 Cyanidioschyzon merolae red algae Galdieria sulphuraria 87 Synechocystis sp. PCC 6803 Microcystis aeruginosa 73 Acaryochloris marina Thermosynechococcus elongatus 78 76 Oscillatoria acuminata 100 Nostoc sp. PCC 7120 Anabaena variabilis cyanobacteria Gloeochaete wittrockiana SAG4.46.84 glaucophyte 100 Prochlorococcus marinus SS120 Paulinella chromatophora 95 Synechococcus sp. WH8102

0.5 1.0 100 Prymnesium parvum_Texoma1 Chrysochromulina polylepis UIO037 IspH Coccolithus pelagicus ssp braarudi PLY182g 100 Emiliania huxleyi 80 Gephyrocapsa oceanica RCC1303 haptophytes 90 Isochrysis galbana CCMP1323 97 Karlodinium micrum CCMP2283 93 98 Karenia brevis CCMP2229 Pavlova sp. CCMP459 Aureococcus anophagefferens CCMP1850 69 98 Durinskia baltica CSIRO CS-38 89 Kryptoperidinium foliaceum CCMP 1326 Odontella aurita isolate 1302-5 100 75 Thalassiosira pseudonana stramenopiles Phaeodactylum tricornutum 88 Karenia brevis CCMP2229 76 Ochromonas sp. CCMP1393 Heterosigma akashiwo CCMP 452 98 Lotharella globosa LEX01 89 Bigelowiella natans CCMP623 chlorarachniophytes 53 Hemiselmis andersenii CCMP644 99 Guillardia theta cryptophytes Rhodomonas abbreviata_CaronLabIsolate 58 Rhodosorus marinus UTEX LB 2760 65 Rhodella maculata CCMP 736 57 Chondrus crispus red algae 95 Galdieria sulphuraria Cyanidioschyzon merolae 100 Chlamydomonas reinhardtii 91 Volvox carteri f. nagariensis 63 Eutreptiella gymnastica NIES-381 euglenid 83 Chlorella variabilis 97 Ostreococcus tauri Micromonas sp. RCC299 green plants 57 89 Physcomitrella patens subsp. patens 99 Selaginella moellendorffii Oryza sativa japonica 80 Arabidopsis thaliana 88 Babesia bovis 79 Theileria parva apicomplexan Plasmodium falciparum 3D7 52 100 Plasmodium vivax parasites 100 Toxoplasma gondii Chromera velia CCMP2878 74 Vitrella brassicaformis CCMP3155 chromerids Heterocapsa rotundata SCCAP K-0483 Peridinium aciculiferum PAER-2 Lepidodinium chlorophorum NIES-1868 Karenia brevis CCMP2229 Protoceratium reticulatum CCCM 535 (=CCMP 1889) Lingulodinium polyedrum CCMP 1738 dinoflagellates 59 Symbiodinium sp. CCMP421 74 Gymnodinium catenatum GC744 Kryptoperidinium foliaceum CCMP 1326 68 83 Durinskia baltica CSIRO CS-38 Heterocapsa rotundata SCCAP K-0483 Lepidodinium chlorophorum NIES-1868 55 Prochlorococcus marinus SS120 100 Synechococcus sp. WH8102 86 Paulinella chromatophora Thermosynechococcus elongatus 100 Anabaena variabilis cyanobacteria Nostoc sp. PCC 7120 Synechocystis sp. PCC 6803 94 Microcystis aeruginosa Acaryochloris marina 96 Trichodesmium erythraeum Gloeochaete witrockiana SAG 46.84 glaucophyte

0.5 1.0