INDEX

Volume 250, July-September, 1989

Acad, B.-A. and Weiss, H. R: Regional modification of status, obesity (dogs), inhalational, hepatobiliary clearance, 02 consumption and coronary flow 1061 cholephilic xenobiotics (rats), 421 during Beta adrenoceptor stimula- postjunctional, anococcygeus muscle local, induced injury to sciatic nerve, his- tion in reperfused canine myocar- (rats), 492 tologic analysis (rats), 406 dium, 611 beta Angiotensin II Acetaminophen, -induced necrosis, hepato- basal activity, phosphatidic acid phos- -adenosine interactions protective effects, cystathionine phatase (rats), 236 heart rate changes, aldosterone release (rats), 667 02 consumption and coronary flow, (rats), 442 Acetylcholine myocardium (dogs), 611 noradrenergic neurotransmission, a-aminobutyric acid outflow, morphine Adrenocorticotropin, acute and chronic vasoconstriction (rats), 433 withdrawal, alpha receptors (guinea phencyclidine administration (rats), antihypertensive mechanism of captopril, pigs), 682 534 renal hypertension (rats), 515 endogenous release, muscarinic modula- Aging, defective modulation, noradrenergic defective modulation, noradrenergic neu- tion, neostriatal slices (rats), 617 neurotransmission, prostaglandins rotransmission, prostaglandins preclinical studies of quinelorane (rats), (rats), 9 (rats), 9 227 Ahlers, S. T., see Barrett, J. E., 788 minimal receptor domains (rabbits), 31 Acetylcholinesterase Ahiers, S. T., see Gleeson, S., 809 nonpeptide receptor antagonists, struc- changes in drinking activity, electrolyte Albelda, S. M., see Howell, R. E., 93 ture-function studies (rats), 867 excretion, diisopropylfluorophos- Albumin Angus, P. W., Mihaly, G. W., Morgan, D. J. phate (rats), 202 active furosemide fraction, urine compo- and Smallwood, R. A.: Oxygen de- discriminative stimulus effects, physo- sition, nephrotic syndrome, 772 pendence of omeprazole clearance stigmine (rats), 241 methotrexate transport, proximal tubule and sulfone and sulfide metabolite muscarinic receptor subtype regulation, (rabbits), 688 formation in the isolated perfused rat tetrahydroaminoacridine (rats), 573 Albuquerque, E. X., see Alkondon, M., 842 liver, 1043 Adenosine Alcohol, luteinizing hormone releasing hor- Anoxia, pulmonary venule contractions, ar- -angiotension II interactions mone, anterior pituitary and gonadal achidonic acid metabolites (guinea heart rate changes, aldosterone release hormones, women, 902 pigs), 1097 (rats), 442 Aldosterone, release and heart rate changes, Anterior pituitary, gonadal hormones and, noradrenergic neurotransmission, adenosine-angiotensin II interac- luteinizing hormone releasing hor- (rats), 433 vasoconstriction tions (rats), 442 mone, alcohol effects in women, 902 pulmonary vasodilator response, adeno- Alkondon, M. and Albuquerque, E. X.: The Antibiotics, transport of imipenem, central sine 5’-triphosphate, pulmonary vas- nonoxime bispyridinium compound nervous system (rats), 979 cular bed (cats), 170 SAD-128 alters the kinetic properties Anticonvulsants Adenosine triphosphatase of the nicotinic acetyicholine recep- amygdala-kindled rats, valproic acid, 1067 cardiac sarcoplasmic reticulum, calmod- tsr ion channel: A possible mecha- CGS 19755, behavioral pharmacological ulin, free oxygen radicals (dogs), 286 nism for antidonal effects, 842 profile (mice), 454 N-ethylmaleimide sensitivity, vanadate Altszuler, N., see Tuman, R. W., 836 Antidepressants, 5-hydroxytryptamine, re- stimulation, nephron (rats), 529 Amiloride analog, inhibition, bradykinin-in- ceptors, differential-reinforcement- Adenosine triphosphate, -sensitive outward duced cytosolic calcium increase of-low rate 72-sec schedule (rats), 52 potassium current, nicorandil, yen- (dogs), 795 Antihypertensive drugs, nonpeptide angio- tricular myocytes (guinea pigs, rab- 2-Amino-4,5-(1,2-cyclohexyl)-7-phospho- tensin II receptor antagonists, struc- bits), 278 nohaptanoic acid, pharmacological ture-function studies (rats), 867 Adipose tissue, modification of adrenergic profile (rats, mice, gerbils), 100 Antinociception status, obesity (dogs), 1061 Amino acids, NMDA receptor site, compet- infused spinal agents, magnitude of tol- Adrenal cortex, nonpeptide angiotensin II itive inhibitors, guanine nucleotides erance, continuous infusion (rats), 1 receptor antagonists, structure-func- tion studies (rats), 867 (rats), 162 opioid, role, histamine and H,-receptors Adrenoceptors a-Aminobutyric acid, changes in cortical ac- (rats), 476 alpha etylcholine, morphine withdrawal, at- serotonergic involvement, tolerance, U- binding site density and contractile re- pha receptors (guinea pigs), 682 50,488H (mice), 508 sponse, vascular tissues (dogs), 1119 ‘y-Aminobutyric acid, release from electri- Antioxidants, protection, glutamate-in- morphine withdrawal, acetylcholine cally stimulated cortical slices, mod- duced cytotoxicity, neuronal cells and a-aminobutyric acid (guinea ulation, GABAS autoreceptors (rats), (mice), 1132 pigs), 682 648 Antonelli, T., see Beani, L., 682 neuropeptide Y, blood vessel response Amrick, C. L., see Bennett, D. A., 454 Anxiolytics to norepinephrine (rabbits), 523 Amygdala, -kindled rats, valproic acid, 1067 behavioral studies, serotonin receptor reduction of outward currents, ventric- Analgesia subtypes (pigeons), 809 ular myocytes (rats), 364 conditional fear-induced, opioid mu and CGS 19755, behavioral pharmacological alpha-i, 1,4,5-inositol trisphosphate for- kappa receptors (rats), 825 profile (mice), 454 mation, ventricular myocytes (rats), effects of phencyclidine-like drugs (mon- Aorta 1141 keys), 197 cellular mechanisms of endothelin (rats), alpha-2 purine antinociception, adenosine recep- 548 catecholamine receptors and mela- tore, spinal cord (rats), 915 contraction, prostaglandins, protein ki- tonin, retina and pineal gland Anderson, D., see McKinney, M., 565 nasa C mechanism (rats), 44 (chicken), 86 Anesthetics Apomorphine, dopaminergic Dl and D2 ag- 1162 Index Vol. 250

onists, behavioral differentiation, methyl-D-aspartate at its receptor Billings, J., see Schonwetter, B. S., 110 stimulus properties (rats), 800 site both in vitro and in vivo, 162 i,3-Bis(2-chloroethyl)-i-nitrosourea, phe- Arachidonic acid Barone, S., Churchill, P. C. and Jacobson, nytoin teratogenicity, embryonic glu- blockade ofEGF-induced uterine contrac- K. A.: Adenosine receptor prodrugs: tathione reductase (mice), 336 tions, indomethacin, nordihydro- Towards kidney-selective di- Bispyridinium, SAD-128, nicotinic acetyl- guaritic acid (rats), 882 alkylxanthines, 79 choline receptor kinetics (frogs), 842 lipoxygenation, interleukin 1 induction, Barrett, J. E., see Gleeson, S., 809 Bjornsson, T. D., Schneider, D. E. and Ber- prostaglandin biosynthesis (rats), Barrett, J. E., Zhang, L., Ahlers, S. T. and ger, H., Jr.: Asprin acetylates fibrin- 714 Wojnicki, F. H.: Acute and chronic ogen and enhances fibrinolysis. Fi- metabolites, pulmonary venule contrac- effects of corticotropin-releasing fac- brinolytic effect is independent of tions, hypoxia and anoxia (guinea tor on schedule-controlled respond- changes in plasminogen activator pigs), 1097 ing and neurochemistry of pigeons, levels, 154 Arai, Y., see Tadano, T., 254 788 Bladder Arnold, W. S., see Trugman, J. M., 1156 Bazzato, G., see Sabatini, S., 910 membrane, phthalate acid esters, trans- Artery Beani, L., Tanganelli, S., Antonelli, T., Si- port effect (toads), 910 adrenoceptor mechanisms (dogs), 1119 monato, M., Spalluto, P., Tomasini, purine antinociception, adenosine recep- basilar, two populations, 5-hydroxytrypt- C. and Bianchi, C.: Changes in cor- tore, spinal cord (rats), 915 amine receptors (dogs), 379 tical acetylcholine and a-aminobu- 9-Blocking drugs, atenolol, stereoselective blood vessel response to norepinephrine, tyric acid outflow during morphine central hypotensive action (rats), 759 neuropeptide Y, sympathetic field withdrawal involve Alpha-i and Al- Blood flow stimulation (rabbits), 523 pha-2 receptors, 682 models of hepatic elimination, taurocho- coronary, nonneurogenic relaxation, field Beaumont, K., Vaughn, D. A. and Healy, D. late, diazepam (rats), 1048 stimulation (cattle), 461 P.: Thiazide diuretic receptors: Au- regional, endothelin effects (monkeys), generation of endothelium-derived relax- toradiographic localization in rat kid- 1125 ing factor, 5-lipoxygenase products ney with [3Hjmetolazone, 414 Blood pressure (dogs), 1055 Beaune, P., see Labbe, G., 1034 catecholaminergic ventrolateral medul- mesenteric, TA3090 actions, electrical Behavior lary neurons, hypotension correla- and mechanical responses (rabbits), conditional fear-induced analgesia, opioid tion, clonidine (rats), 642 1079 mu and kappa receptors (rats), 825 desoxycorticosterone acetate-sodium hy- prejunctional inhibitory effect of N-0437, differential-reinforcement-of-low-rate pertensive rats, SCH 39370, atrial vascular adrenergic responses (rats), 72-second natriuretic factor, 624 853 5-hydroxytryptamine, receptors (rats), L-glutamate as neurotransmitter, barore- Ascorbic acid, preclinical studies of quinlor- 60 ceptor information, nucleus of trac- ane (rats), 227 5-hydroxytryptamine-2 antagonists tus solitarius (rats), 953 Aspirin, acetylation of fibrinogen and en- (rats), 52 mediation, serotonin receptors, m-chlo- hanced fibrinolysis (humans), 154 role of noradrenaline, anxiogenic actions, rophenylpiperazine (rats), 72 Assays, radioligand binding, characteriza- benzodiazepine receptor agonist rise, cyclosporine, decreased renal vascu- tion of D2 receptors, caudate (dogs), (rats), 358 lar responses (rats), 1105 110 schedule-controlled, corticotropin-releas- B-lymphopoiesis, bone marrow stromal cell Atenolol, stereoselective central hypoten- ing factor, neurochemistry (pigeons), regulation, hydroquinone (mice), 582 sive action (rats), 759 788 BM 13.177, combined with streptokinase, Atrial natriuretic factor Bend, J. R., see Tracey, W. R., 1097 thrombolytic synergy (dogs), 887 mediation of inhibitory effect, cyclic Benishin, C. G., see Zeng, Y. Y., 343, 352 BMY 7378, serotonin receptor subtypes, be- GMP, pheochromocytoma cells, 428 Bennett, B. M., Leitman, D. C., Schroder, havioral studies, anxiolytic drugs (pi- SCH 39370, desoxycorticosterone ace- H., Kawanioto, J. H., Nakatsu, K. geons), 809 tate-sodium hypertensive rats, 624 and Murad, F.: Relationship between BMY-25405, histamine H1 and H2 receptors, Autoradiography biotransformation of glyceryl trini- cardiovascular actions (rats), 500 [‘4C]-2-deoxyglucose, Dl dopamine ago- trate and cyclic GMP accumulation Bobker, D. H. and Williams, J. T.: Sero- nist effects (rats), 1156 in various cultured cell lines, 316 tonin agoni8ts inhibit synaptic po- localization in kidney with metolazone, Bennett, D. A., Bernard, P. 5., Amrick, C. tentials in the rat locus ceruleus in thiazide diuretic receptors (rats), 414 L., Wilson, D. E., Liebman, J. M. and vitro via 5-hydroxytryptoaminelA and Autoreceptors, GABAB, GABA release, cor- Hutchison, A. J.: Behavioral phar- 5-hydroxytryptamine15 receptors, 37 tical slices (rats), 648 macological profile of CGS 19755, a Bonanno, G., see Raiteri, M., 648 Ayesta, F. J. and Fl#{243}rez,J.: Tolerance to competitive antagonist at N-methyl- Bone marrow, stromal cell regulation, B- respiratory actions of sufentanil: D-asparate receptors, 454 lymphopoiesis, hydroquinone (mice), Functional tolerance and route-de- N-[i-(2-Benzo(B)thiophenyl)cyclohexyljpi- 582 pendent differential tolerance, 371 peridine, behavioral effects (mice, Borosky, S., see Ferkany, J. W., 100 rats, pigeons), 1019 Boselli, C., see Kenakin, T., 944 B#{228}#{228}rnhielm,C., see Wang, S.-X., 632 Benzodiazepines, intravenous lorazepam Bousquet, P., see Tibrica, E., 642 Bagdy, G., Szemeredi, K., Kanyicska, B. and compared to diazepam, kinetic and Bowden, C. R, see Tuman, R. W., 836 Murphy, D. L.: Different serotonin dynamic study (humans), 134 Bradykinin, -induced increase of cytosolic receptors mediate blood pressure, Berger, H., Jr., see Bjornsson, T. D., 154 calcium, inhibition, novel amioride heart rate, plasma catecholamine and Berlan, M., see Taouis, M., 1061 analog (dogs), 795 prolactin responses to m-chlorophen- Bernard, P. S., see Bennett, D. A., 454 Brain ylpiperazine in conscious rats, 72 Bertrand, C., see Gies, J.-P., 309 amygdala-kindled rats, valproic acid, 1067 Balduini, W. and Costa, L. G.: Effects of Besseghir, K., Mosig, D. and Roch-Ramel, basal ganglia neuropeptide systems, co- ethanol on muscarinic receptor-stim- F.: Transport of methotrexate by the caine (rats), 818 ulated phosphoinositide metabolism in vitro isolated rabbit proximal to- calcium release from microsomes, during brain development, 541 bule, 688 ethanol, 1,4,5-inositol trisphosphate Balster, R. L, see Ferkany, J. W., 100 Bianchi, C., see Beani, L,, 682 (mice), 875 Barnett, A., see Sybertz, E. J., 624 Bickel, W. K., see Preston, K. L., 184 catecholaminergic ventrolateral medal- Baron, B. M., Dudley, M. W., McCarty, D. Bigelow, G. E., see Preston, K. L., 184 lary neurons, hypotension correla- R., Miller, F. P., Reynolds, I. J. and Bigelow, G. E., see Heishman, S. J., 485 tion, clonidine (rats), 642 Schmidt, C. J.: Guanine nucleotides Bile, output of methotrexate, structural development, ethanol, phosphoinositide are competitive inhibitors of N- specificity (rats), 221 metabolism (rats), 541 1989 Index 1163

muscarinic receptor subtype regulation, urinary excretion, 5-8666 effect (rats), To, A. C. S. and Volicer, L.: Increased tetrahydroaminoacridine (rats), 573 654 serotonin efflux by a partially oxi- neostriatal slices, endogenous acetylcho- Calcium channel dized serotonin: Tryptamine-4,5- line release, muscarinic modulation actions ofTA3O9O, electrical and mechan- dione, 141 (rats), 617 ical responses, mesenteric artery Chiba, S. see Horiuchi, A.see 734 para-hydroxyamphetamine-induced (rabbits), 1079 Ching, M. S., Morgan, D. J. and Smallwood, head-twitch response, inhibition, blocking properties, PD 122860 (rats), 22 R. A.: Models of hepatic elimination: monoamine oxidase type A (mice), gating Implications from studies of the si- 254 fluoride, vascular smooth muscle (rats), multaneous elimination of taurocho- raclopride kinetics and distribution, do- 343 late and diazepam by isolated rat pamine D2 receptors (rats, rabbits), guanosine 5’-(’y)triphosphate, vascular liver under varying conditions of 696 smooth muscle (rats), 352 binding, 1048 release of GABA from electrically stimu- neuronal, changes, ethanol tolerance Chiorazzi, N., see Novick, D. M., 606 lated cortical slices, modulation, GA- (rats), 985 Chiu, A. T., Duncia, J. V., McCall, D. E., BA5 autoreceptors (rats), 648 Calmodulin, free oxygen radicals and, cal- Wong, P. C., Price, W. A., Jr., striatal and brainstem M2 muscarinic re- ium accumulation, cardiac sarco- Thoolen, M. J. M. C., Carmni, D. J., ceptors, cyclic AMP inhibition (rats), plasmic reticulum (dogs), 286 Johnson, A. L. and Timmermans, P. 565 Calyculin-A, contractile apparatus in B. M. W. M.: Nonpeptide angioten- tyrosine availability, ethanol sensitivity, smooth muscle, calcium-independent sion II receptor antagonists. III. long- and short-sleep mice, 556 activation (rats, guinea pigs), 388 Structure-function studies, 867 Brater, D. C., see Voelker, J. R., 772 Cannabinoids, dimethyl homologs of ii-hy- Chiu, P. J. S., see Sybertz, E. J., 624 Bremazocine, diuretic effect (rats), 992 droxy-8-tetrahydrocannabinol, m-Chlorophenylpiperazine, mediation of BRL 34915 stereospecificity, discriminative blood pressure, serotonin receptors potassium channel opener, inhibition by stimulus functions (rats, pigeons), (rats), 72 glibenclamide (rabbits, rats), 261 1000 Chlorpheniramine, histamine H, and H2 re- stimulation of potossium efflux, arteries, Captopril, antihypertensive mechanism, ceptors, cardiovascular actions (rats), calcium modulation (rabbits), 591 renal hypertension (rats), 515 500 Bromocriptine, autoradiographic assess- Carbamylcholine, comparison of contrac- Cho, A. K., Hiramatsu, M., Pechnick, R. N. ment, Di dopamine agonist effects tions, contractile agonists, stomach and Di Stefano, E. : Pharmacokinetic (rats), 1156 fundus (rats), 971 and pharmacodynamic evaluation of Bronchoconstriction, endothelin-mediated, Cardiotonic agents, MCI-154, myofilament phencyclidine and its decadeutero mechanisms (guinea pigs), 740 force, ATPase activity (dogs), 272 variant, 210 Bronner, C., see Mousli, M., 329 Carmni, D. J., see Chiu, A. T., 867 Cho, A. K., see Pechnick, R. N., 534 Brown, K. E., see Schleimer, R. P., 598 Carotid sinus nerve, serotonin-induced in- Choi, D. W., see Hartley, D. W., 752 Budai, D., see Friedman, D. J., 853 crease in activity, GR38032F (rats), Choroid plexus, cefodizime transport (rats), Bueb, J.-L., see Mousli, M., 329 637 324 Gusse, 1006 Bueno, L., see M., Carr, C., see Mayeux, P. R., 923 Churchill, P. C., see Barone, S., 79 Buprenorphine, opioid agonist/antagonist, Catecholamines Churchill, P. C., see Rossi, N. F., 891 drug discrimination, human postad- adrenergic agonists and Na-K-ATPase, Clarithromycin, cytochrome P-450 effects, dicts, 184 proximal tubules, basolateral mem- comparison, other macrolides (rats), Burchett, K., see Ferkany, J. W., 100 branes (rabbits), 672 746 blood pressure mediation, serotonin re- Clay, K. L., see French, T. A., 556 Caffeine, heart rate changes and aldosterone ceptors, m-chlorophenylpiperazine Clemens, J. A., see Foreman, M. M., 227 release, adenosine-angiotensin II in- (rats), 72 Clonidine teractions (rats), 442 long- and short-sleep mice, ethanol sen- discriminative stimulus effects, naltrex- Calcagnetti, D. J., see Fanselow, M. S., 825 sitivity, brain tyrosine availability, one, morphine treatment (monkeys), Calcium 556 937 ventrolateral medullary neurons, hypo- hypotension, catecholaminergic ventro- cytosolic, inhibition, bradykinin-induced tension correlation, clonidine (rats), lateral medullary neurons (rats), 642 . increases (dogs), 795 endothelin cellular mechanisms in aorta 642 Clozel, J.-P., see Clozel, M., 1125 (rats), 548 Caudate, characterization of D2 receptors, Clozel, M. and Clozel, J.-M.: Effects of en- furosemide-induced diuresis, additive di- radioligand binding assay (dogs), 110 dothelin on regional blood flows in uretic effect, 5-8666 (rats), 659 Cavero, I., see Marquis, 0., 293 squirrel monkeys, 1125 -independent activation ofcontractile ap- Cefodizime, cephalosporin and, transport in Cocaine paratus, smooth muscle, calyculin-A choroid plexus (rats), 324 behavioral effects ofphencyclidine analog (rats, guinea pigs), 388 Central nervous system (mice, rats, pigeons), 1019 ionic and secretory events, pancreatic is- changes in drinking activity, electrolyte serotonin agonists, inhibited synaptic po- lets, pinacidil and diazoxide (rats), excretion, diisopropylfluorophos- tentials, locus ceruleus (rats), 37 1011 phate (rats), 202 striatonigral dynorphin levels, dopami- modulation, potassium efflux from arter- transport of imipenem (rats), 979 nergic mechanism (rats), 818 ies, BRL 34915 (rabbits), 591 Cerebral cortex Cohen, M. L., see Secrest, R. J., 971 NMDA receptor site, competitive inhibi- NMDA receptor-mediated neuronal in. Colpaert, F. C., see Koek, W., 1019 tore, guanine nucleotides (rats), 162 jury, delayed rescue, cortical culture Confort-Gouny, S., see Vion-Dury, J., 1113 reduction of outward currents, alpha ad- (mice), 752 Convulsions, behavioral effects of phency- renoceptor stimulation, ventricular raclopride kinetics and distribution, do- clidine analog (mice, rats, pigeons), myocytes (rats), 364 pamine D2 receptors (rats, rabbits), 1019 release from separate stores of brain mi- 696 Cook, N. S., see Quast, U., 261 crosomes, ethanol, 1,4,5-inositol tris- CGS 19755, behavioral pharmacological Cornfeldt, M., see Locke, K. W., 241 phosphate (mice), 875 proffle (mice), 454 Corpus striatum steady-state accumulation, cahnodulin Chemoreceptors, serotonin-induced in- comparative anticholinergic properties, and free oxygen radicals, cardiac sar- crease, carotid sinus nerve activity, thioridazine, mesoridazine and sul- coplasmic reticulum (dogs), 286 GR38032F (rats), 637 foridazine (rabbits), 126 stimulation of myofilament force, ATP- Chemotaxis, glucocorticoid effects, leuko- comparative antidopaminergic properties, ase activity and MCI-154, cardiac triene B4 formation, neutrophils, 598 thioridazine, mesoridazine and sul- muscle (dogs), 272 Chen, J.-C., Crino, P. B., Schnepper, P. W., foridazine (rabbits), 117 I 164 Index Vol. 250

Corticosterone lease calcium from separate stores of Dingledine, R., see Ferkany, J. W., 100 acute and chronic phencyclidine admin- brain microsomes, 875 Discriminative stimulus istration (rats), 534 Deoxyglucose, autoradiographic assess- D-amphetamine or pentobarbital, hista- preclinical studies of quinelorane (rats), ment, Dl dopamine agonist effects mine H,-antagonists (pigeons, mon- 227 (rats), 1156 keys), 779 Corticotropin-releasing factor, acute and Depression behavioral differentiation and, dopami- chronic effects, schedule-controlled 5-hydroxytryptamine-2 antagonists nergic Dl agonist, D2 agonist (rats), responding, neurochemistry (pi- (rats), 52 800 geons), 788 5-hydroxytryptamine1 receptors, antide- effects of physostigmine (rats), 241 Cory-Slechta, D. A., Widzowski, D. V. and pressant-like drug effects (rats), 60 naltrexone effect, morphine treatment Newland, M. C.: Behavioral differ- Derse, C. P., see Schleimer, R. P., 598 (monkeys), 937 entiation of the stimulus properties Descatoire, V., see Labbe, G., 1034 stereospecificity, dimethyiheptyl homo- of a dopaminergic Dl agonist from a Descatoire, V., see Tinel, M., 746 logs, 11-hydroxy-M-tetrahydrocan- D2 agonist, 800 Desmoulin, F., see Vion-Dury, J., 113 nabinol (rats, pigeons), 1000 Costa, L. G., see Balduini, W., 541 Desoxycorticosterone acetate, -sodium hy- Di Stefano, E., see Cho, A. K., 210 Coustaut, D., see Vion-Dury, J., 1113 pertensive rats, SCH 39370, atrial Diuresis Coyle, J. T., see Miyamoto, M., 1132 natriuretic factor, 624 active furosemide fraction, urine compo- Coyne, D. W., Mordhorst, M., Cragoe, E. J. Deutsch, J. C. and Kolhouse, J. F.: Struc- sition, nephrotic syndrome, 772 and Morrison, A. R.: Inhibition of tural specificity of mechanisms con- atrial natriuretic factor responses to SCH bradykinin-induced increases of cy- trolling the hepatic uptake and bili- 39370, desoxycorticosterone acetate- tosolic Ca by a novel amioride an- ary output of methotrexate in the rat, sodium hypertensive rats, 624 alog, 795 221 effect of bremazocine (rats), 992 Cozzone, P. J., see Vion-Dury, J., 113 Devoisselle, J. M., see Vion-Dury, J., 113 Diuretics Cragoe, E. J., see Coyne, D. W., 795 Devreux, V., see Lebrun, P., 1011 adenosine receptor prodrugs, kidney-se- Crino, P. B., see Chen, J.-C., 141 Dewar, K. M., Montreuil, B., Grondin, L. lective dialkylxanthines, 79 Cromakalim, see BRL 34915 and Reader, T. A.: Dopamine D2 re- glutathione depletion in kidney, vulnera- Croxson, T. S., see Novick, D. M., 606 ceptors labeled with [3Hjraclopride in bility, thick ascending limb (rats), Cubeddu, L. X., see Niedzwiecki, D. M., 117, rat and rabbit brains. Equilibrium 247 126 binding, kinetics, distribtuion and se- 5-8666 effect Cyclic AMP lectivity, 696 furosemide (rats), 659 atrial and ventricular contractile re- Dexamethasone urinary calcium excretion (rats), 654 sponses, somatostatin, heart (guinea glucocorticoid effects on neutrophils, leu- thiazide diuretic receptors, autoradi- pigs), 726 kotriene B4 formation, 598 ographic localization, metolazone cellular mechanisms of endothelin, aorta phosphatidic acid phosphatase, basal ac- (rats), 414 (rats), 548 tivity, neonatal lung (rats), 236 Dolin, S. J. and Little, H. J.: Are changes in intraperitoneal endotoxin, D-tubocura- Dextrorphan neuronal calcium channels involved rime, gastrocnemius muscle (mice), analgesic effects (monkeys), 197 in ethanol tolerance, 985 216 NMDA receptor-mediated neuronal in- Donati, D., see Mugridge, K. G., 714 mediation ofinhibition using selective an- jury, delayed rescue, cortical culture Dopamine tagonists, striatal and brainstem M2 (mice), 752 basal ganglia neuropeptide systems, co- muscarinic receptors (rats), 565 Diabetes, recovery from insulin-induced caine (rats), 818 Cyclic GMP hypoglycemia, recovery, methyl pal- Dl agonist effects, autoradiographic as- accumulation, glyceryl trinitrate, bio- moxirate effect (dogs), 836 sessment (rats), 1156 transformation, 316 Dialkylxanthines, kidney-selective, adeno- D2-dopaminergic agonist, quinelorane, desoxycorticosterone acetate-sodium hy- sine receptor prodrugs, 79 preclinical studies (rats), 227 pertensive rats, SCH 39370, atrial Diazepam mediation of inhibitory effect by cyclic natriuretic factor, 624 compared to intravenous lorazepam, ki- GMP, atrial natriuretic factor, pheo- mediation of inhibitory effect, atrial na- netic and dynamic study (humans), chromocytoma cells, 428 triuretic factor, pheochromocytoma 134 prejunctional inhibitory effect of N-0437, cells, 428 models of hepatic elimination (rats), 1048 vascular adrenergic responses (rats), Cyclooxygenase, contraction of pulmonary Diazoxide 853 venules, induction by hypoxia and pinacidil and, ionic and secretory events, Drapeau, G., see Patacchini, R., 678 anoxia (guinea pigs), 1097 pancreatic islets (rats), 1011 Drewett, J. G., Ziegler, R. J., Marchand, G. Cyclosporine A potassium channel opener, inhibition by R. and Trachte, G. J.: Cyclic guano- -induced renal vasoconstriction, mecha- glibenclamide (rabbits, rats), 261 sine 3’, 5’ monophosphate mediates nism (rats), 896 Diethylenetriaminopentaacetic acid, -gado- the inhibitory effect of atrial natri- rise in blood pressure, decreased renal linium, liposome-mediated delivery, uretic factor in adrenergic, neuronal vascular responses (rats), 1105 hepatic cells, 1113 pheochromocytoma cells, 428 Cystathionine, hepatoprotective effects, ac- Dihydropyridine Drug discrimination, see also Discriminative etaminophen-induced necrosis (rats), changes in neuronal calcium channels, stimulus 667 ethanol tolerance (rats), 985 opioid agonist/antagonist, human postad- Cytochrome P-450 contraction of pulmonary venules, induc- contribution of intestine, first-pass me- dicts, 184 tabolism, felodipine (rats), 632 Duckles, S. P., see Friedman, D. J., 853 tion by hypoxia and anoxia (guinea PD 122860, sodium channel stimulation, Dudley, M. W., see Baron, B. M., 162 pigs), 1097 calcium channel blocking properties Duesler, J. G., Jr., see Hieble, J. P., 523 effects of clarithromycin, comparison, Dulaney, M. D., Jr., Rockhold, R. W., Por- other macrolides (rats), 746 (rats), 22 suicide inactivation, methoxsalen (rats), Diisopropylfluorophosphate, changes in ter, A. C., Hoskins, B. and Ho, I. K.: 1034 drinking activity, urine volume, elec- Changes in drinking activity, urine trolyte excretion (rats), 202 volume and urinary electrolyte excre- 4,5-Diketotryptamine, increased serotonin tion after interacerebroventricular Daly, R. N., see Hieble, J. P., 523 efflux, partially oxidized serotonin administration of diisopropylfluoro- D’Ambrosio, R., see Nichols, A. I., 963 (rats), 141 phosphate, 202 Daniel, E. E., see Shi, A. G., 1119 Diltiazem, inhibitory actions of TA3090, Dumont, P., see Gies, J.-P., 309 Daniell, L. C. and Harris, R. A.: Ethanol electrical and mechanical responses, Duncia, J. V., see Chiu, A. T., 867 and inositol 1,4,5-trisphosphate re- mesenteric artery (rabbits), 1079 Duncia, J. V., see Wong, P. C., 515 1989 Index 1165

Dynorphin, striatonigral levels, cocaine, do- nositide metabolism, brain develop- Foster, C. J., see Sybertz, E. J., 624 paminergic mechanism (rats), 818 ment (rats), 541 Foust, J. M., see Gleeson, S., 809 sensitivity in long- and short-sleep mice, Fracasso, A., see Sabatini, S., 910 brain tyrosine availability, 556 France, C. P., Snyder, A. M., and Woods, J. Eberle, N. B., see Gogas, K. It, 476 tolerance, changes, neuronal calcium H.: Analgesic effects of phencycli- Edema, local anesthetic-induced injury, channels (rats), 985 dine-like durgs in rhesus monkeys, sciatic nerve, histologic analysis N-Ethylmaleimide, -sensitive adenosine tri- 197 (rats), 406 phosphataae, vanadate stimulation, France, C. P. and Morse, W. H.: Pharma- Ehrenberg, B. L., see Greenblatt, D. J., 134 nephron (rats), 529 cological characterization of super- Elastase, degranulatory responses in PAF Evans, S. M. and Johanson, C. E.: Discrim- sensitivity to naltrexone in squirrel receptors, polymorphonuclear leuko- inative stimulus properties of hista- monkeys, 928 cytes (humans), 293 mine H1-antagothsts in animals France, C. P. and Woods, J. H.: Discrimi- Electrolytes, urinary excretion, drinking ac- trained to discriminate d-ampheta- native stimulus effects of naltrexone tivity, diisopropylfluorophosphate mine or pentobarbital, 779 in morphine-treated rhesus monkeys, (rats), 202 EXP6803, nonpeptide angiotensin II recep- 937 El-Fakahany, E. E., see McKinney, M., 565 tor antagonists, structure-function Freeland, H. S., see Schleimer, It P., 598 Elias, M. M., see Torres, A. M., 247 studies (rats), 867 French, T. A., Clay, K. L. and Weiner, N.: Ellenberger, S. R., see Ferkany, J. W., 100 Role of brain tyrosine availability in EIIIngbOe, J.see Mendelson, J. H., 902 mediating differences in ethanol sen- Ellis, V. R, see Rossi, N. F., 891 Fan, Z., see Hiraoka, M., 278 sitivity in long-sleep and short-sleep Endothelin Fanselow, M. S., Calcagnetti, D. J., and mice, 556 cellular mechanisms in aorta (rats), 548 Helmstetter, F. J.: Role of mu and Frenken, M. and Kaumann, A. J.: Dimethy- effects on regional blood flow (monkeys), kappa opoiod receptors in conditional lation of the activator IC! 169,369 1125 fear-induced analgesia: The antago- results in a high-affinity partial deac- -mediated bronchoconstriction, mecha- nistic actions of norbinaltorphimine tivator, IC! 170,809, of the arterial 5- nisms (guinea pigs), 740 and the cyclic somatostatin octapep- hydroxytryptamine2 receptor system, Endotheium tide CysTyrOrn6Pen7-amide, 825 707 pulmonary extraction ofpropranolol, nor- Fatty acids, recovery from insulin-induced Frenken, M.: Evidence for two populations mal and oxygen-toxic sheep, 93 hypoglycemia, recovery, methyl pal- of 5-hydroxtryptamine receptors in vascular, glucocorticoid effects, neutro- moxirate effect (dogs), 836 dog basilar artery, 379 phils, 598 Fedele, E., see Raiteri, M., 648 Friedman, D. J., Budai, D., Krause, D. N. Endotheium-derived relaxing factor Feldman, J., see Tibrica, E., 642 and Duckles, S. P.: Prejunctional decreased renal vascular responses, rise in Felodipine, contribution of intestine, first- inhibitory effect of a dopamine D-2 blood pressure, cyclosporine (rats), pass metabolism (rats), 632 agonist, N-0437, on vascular adrener- 1105 Ferkany, J. W., Kyle, D. J., Willets, J., gic responses, 853 endothelin cellular mechanisms in aorta Rzeszotarski, W. J., Guzewska, M. E., Fuller, R. W., see Foreman, M. M., 227 (rats),548 Ellenberger, S. R., Jones, S. M., Sa- Furosemide generation, 5-lipoxygenase PrOdUCts caan, A. I., Snell, L. D., Borosky, S., diuretic resistance, nephrotic syndrome, (dogs), 1055 Jones, B. E., Johnson, K. M., Balster, 772 Endotoxin, intraperitoneal, D-tuboCurarine R. L., Burchett, K., Kawasaki, K., 5-8666 effect dose-response curves, gastrocnemius Hoch, D. B. and Dingledine, R.: additive diuretic effect (rats), 659 muscle (mice), 216 Pharmacological profile of NPC urinary calcium excretion (rats), 654 Endou, M., Hattori, Y., Nakaya, H. and 12626, a novel, competitive N- Fusetani, N., see Ishihara, H., 388 Kanno, M.: Differential effects of so- methyl-D-aspartate receptor antago- matostatin on atrial and ventricular nist, 100 contractile responses in guinea pig Fetal alcohol syndrome, ethanol effects, Gadolinium, -diethylenetriaminopentaa- . heart: Influence ofpretreatment with phosphoinositide metabolism, brain cetic acid, liposome-mediated deliv- islet-activating protein, 726 development (rats), 541 ery, hepatic cells, 1113 Enkephalin Fibrinogen, acetylation by aspirin, en- Gaffney, T. E., see Pearson, A. A., 759 basal ganglia neuropeptide systems, co- hanced fibrinolysis (humans), 154 Gallamine, pirenzepine and, antagonism of caine (rats), 818 Fielding, S., see Locke, K. W., 241 muscarinic responses, trachea (rats), conditional fear-induced analgesia, opioid Fisher, J. E., see Loscher, W., 1067 944 mu and kappa receptors (rats), 825 Fishman, A. P., see Howell, R. E., 93 Gardner, R M. and Stancel, G. M.: Block- effects of opioid agonists, sympathetic Fl#{243}rez,J., see Ayesta, F. J., 371 ade of epidermal growth factor-in- and parasympathetic transmission, Fluoride, gating ofcalcium channels, G-pro- duced uterine contractions by indo- heart (dogs), 1087 teins, vascular smooth muscle (rats), methacin or nordihydroguaritic acid, Epidermal growth factor, -induced uterine 343 882 contractions, blockade, indometha- Flynn, D. D. and Mash, D. C.: Multiple in Gastric function, relaxation induced by cm or nordihydroguaritic acid (rats), vitro interactions with and differen- feeding, central and peripheral opioid 882 tial in vivo regulation of muscarinic modulation (dogs), 1006 Epilepsy, amygdala-kindled rats, valproic receptor subtypes of tetrahydroami- Gentamicin, nephrotoxicity, protection, pa- acid, 1067 noacridine, 573 lyaspartic acid (rats), 149 Epinephrine, preclinical studies of quinelor- Folate, methotrexate transport, proximal George, R. see Pechnick, R. N., 534 ane (rats), 227 tubule (rabbits), 688 Gerkens, J. F.: Cyclosporine treatment of Erythroleukemia cells, functional throm- Foic acid, hepatic uptake and biliary out- normal rats produces a rise in blood boxane Aprostaglandin H2 recep- put, methotrexate, structural speci- pressure and decreased renal vascular tore, 923 ficity (rats), 221 responses to nerve stimulation, vas- Erythromycin acistrate, erythromycin Fofficle-stimulating hormone, alcohol ef- oconstrictors and endothelium-de- stearate and, efficacy, infections fecta in women, 902 pendent dilatora, 1105 (mice), 1028 Foreman, M. M., Fuller, R. W., Hynes, M. Gertner, S. B., see Poulakos, J. J., 500 Estan, L., see Taouis, M., 1061 D., Gidda, J. S., Nichols, C. L., Gessner, G., see Pendleton, R. G., 31 Estradiol, alcohol effects in women, 902 Schaus, J. M., Kornfeld, E. C. and Ghali, V., see Novick, D. M., 606 Ethanol Clemens, J. A.: Precinical studies on Gidda, J. S., see Foreman, M. M., 227 1,4,5-inositol trisphosphate and, calcium quinelorane, a potent and highly se- Gies, J.-P., Bertrand, C., Vanderheyden, P., release, brain microsomes (mice), 875 lective D2-dopaminergic agonist, 227 Waeldele, F., Dumont, P., Pauli, G. muscarinic receptor-stimulated phosphoi- Forray, C., see McKinney, M., 565 and Landry, Y.: Characterization of 1166 Index Vol. 250

muscarinic receptors in human, guanosine 5’-(-y)triphosphate, vascular that prostaglandins can contract the guinea pig and rat lung, 309 smooth muscle (rats), 352 rat aorta via a novel protein kinase Gies, J.-P., see Mousli, M., 329 Guanine nucleotide regulatory protein, at- C-dependent mechanism, 44 Gleeson, S., Ahlers, S. T., Mansbach, R S., pha-1 stimulation, 1,4,5-inositol tris- Heishman, S. J., Stitzer, M. L., Bigelow, G. Foust, J. M. and Barrett, J. E.: Be- phosphate formation, ventricular E. and Liebson, I. A.: Acute opioid havioral studies with anxiolytic myocytes (rats), 1141 physical dependence in humans: Ef- drugs. VI. Effects on punished re- Guanine nucleotides, competitive inhibitors fect ofvaring the morphine-naloxone sponding of drugs interacting with of NMDA, receptor site (rats), 162 interval. I, 485 serotonin receptor subtypes, 809 Guanosine 5’-(-y)triphosphate, gatingofcal- Helmstetter, F. J., see Fanselow, M. S., 825 Glibenclamide, inhibition of potassium cium channels, G-proteins, vascular Hepatobiliary clearance, inhalational anes- channel openers, diazoxide and cro- smooth muscle (rats), 352 thetics, cholephilic xenobiotics (rats), makalim (rabbits, rats), 261 Gume, M., Junien, J. L. and Bueno, L.: 421 Glick, S. D., see Gogas, K. R., 476 Central and peripheral opioid modu- Hepatotoxicity, hepatoprotective effects of Glucocorticoids, degranulation and chemo- lation of gastric relaxation induced cystathionine, acetaminophen-in- taxis effects, vascular endotheium, by feeding in dogs, 1006 duced necrosis (rats), 667 neutrophils, 598 Gunderman, J., see Greenblatt, D. J., 134 Herchuelz, A., see Lebrun, P., 1011 Glutamate Guzewska, M. E., see Ferkany, J. W., 100 Hermann, M., see Lebrun, P., 1011 -induced cytotoxicity, protection with an- Heroin, abusers and long-term methadone tioxidants, neuronal cells (mice), maintenance, natural killer cell activ- Haleen, S. J., Steffen, B,. P., Sircar, I., Ma- 1132 ity, lymphocyte subsets, 606 jor, T. C., Taylor, M. D., Pugsley, T. NMDA receptor-mediated neuronal in- Hieble, J. P., Duesler, J. G., Jr. and Daly, A. and Weishaar, R. E.: PD 122860: jury, delayed rescue, cortical culture R. N.: Effects of neuropeptide Y on A novel dihydropyridine with sodium (mice), 752 the response of isolated blood vessels channel stimulating and calcium L-Glutamate, neurotransmitter of barore- to norepinephrine and sympathetic channel blocking properties, 22 ceptor information, nucleus, tractus field stimulation, 523 Haloperidol, dopaminergic Dl and D2 ago- solitarius (rats), 953 Hiltunen, A. J., see J#{225}rbe,T. U. C., 1000 nists, behavioral differentiation, -y-Glutamyltransferase, adenosine receptor Hippocampus stimulus properties (rats), 800 prodrugs, kidney-selective di- muscarinic receptors in lung (humans, Halushka, P. V., see Mayeux, P. R., 923 alkylxanthines, 79 guinea pigs, rats), 309 Hamilton, J. T., see Tracey, W. R., 1097 Glutathione raclopride kinetics and distribution, do- Hanano, M., see Nohjoh, T., 324 acetaminophen-induced necrosis, hepa- pamine D2 receptors (rats, rabbits), Hanano, M., see Suzuki, H., 979 toprotective effects, cystatbionine 696 Hanhij#{225}rvi, H., see M#{220}nniSt#{212},P. T., 1028 (rats), 667 Hiramatsu, M., see Cho, A. K., 210 Hansen-Flaschen, J. H., see Howell, R. E., depletion in kidney, vulnerability, thick Hiramatsu, M., see Pechnick, R. N., 534 93 Hiraoka, M. and Fan, Z.: Activation of ATP- ascending limb (rats), 247 Harf, A., see Macquin-Mavier, I., 740 Glutathione reductase, embryonic, phenyt- sensitive outward K current by m- Harmatz, J. S., see Greenblatt, D. J., 134 Oin teratogenicity, corandil (2-mcotinamidoethyl ni- 1,3-bis(2-chloro- Harris, R. A., see Daniell, L. C., 875 ethyl)-1-nitrosourea (mice), 336 Hartley, D. M. and Choi, D. W.: Delayed trate) in isolated ventricular my- ocytes, 278 Glyceryl trinitrate, cyclic GMP accumula- rescue of N-methyl-D-asparate re- Histamine tion and, biotransformation, 316 ceptor-mediated neuronal injury in Glycosides, cardiac distribution, skeletal cortical culture, 752 H1-antagonists, discriminative stimulus muscle Na,K-pump concentration, Hartahorne, D. J., see Ishihara, H., 388 properties, D-amphetamine or pen- children, 721 Haselton, F. R., see Howell, R B., 93 tobarbital (pigeons, monkeys), 779 Gogas, K. R., Hough, L B., Eberle, N. B., Hashimoto, K., see Ishihara, H., 388 H2-receptors and, role, opioid antinoci- Lyon, R. A., Glick, S. D., Ward, S. J., Haslanger, M. F., see Sybertz, E. J., 624 ception (rats), 476 Young, R C. and Parsons, M. E.: A Hattori, Y., see Endou, M., 726 Ho, B. Y. and Takemori, A. E.: Serotonergic role for histamine and H2-receptors Havas, A., see M#{228}nnisto, P. T., 1028 involvement in the antinociceptive in opioid antinociception, 476 Hay, D. W. P., see Ohlstein, E. H., 548 action of and the development of tol- Gonadal hormones, anterior pituitary and, Healy, D. P., see Beaumont, K., 414 erance to the kappa-opoid receptor luteinizing hormone releasing hor- Heart agonist, U-50,488H, 508 mone, alcohol effects in women, 902 atrial and ventricular contractile re- Ho, I. K., see Dulaney, M. D., Jr., 202 Gonon, F., see Tibrica, E., 642 spouses, differential effects, somato- Hoch, D. B., see Ferkany, J. W., 100 Gordon, F. J., see Leone, C., 953 statin (guinea pigs), 726 Holycross, B. J., Ping, L and Jackson, E. Gorney, B., see Locke, K. W., 241 cardiac sarcoplasmic reticulum, calmod- K.: Adenosine-angiotensin II inter- Greenblatt, D. J., Ehrenberg, B. L, Gunder- ulin, free oxygen radicals (dogs), 286 actions. Part II. The role of adenosine man, J., Scavone, J. M., Tai, N. T., cardiovascular actions, central histamine in regulating angiotensin Il-induced Harmatz, J. S. and Shader, R. I.: Ki- H1 and H2 receptors (rats), 500 changes in heart rate and aldosterone netic and dynamic study of intrave- effects of opioid agonists, sympathetic release, 442 nous lorazepam: Comparison with in- and parasympathetic transmission Holycross, B. J. and Jackson, E. K.: Aden- travenous diazepam, 134 (dogs), 1087 osine-angiotensin II interactions. GR38032F electrophysiologic effects, ketanserin Part I. Role of adenosine in regulat- serotonin-induced increase, carotid sinus (dogs), 397 ing angiotensin Il-induced potentia- nerve activity (rats), 637 glycoside distribution, skeletal muscle Na, tion of noradrenergic neurotransmis- serotonin receptor subtypes, behavioral K-pump concentration, children, 721 sion and angiotensin il-induced vaso- studies, anxiolytic drugs (pigeons), muscarinic receptors in lung (humans, constriction, 433 809 guinea pigs, rats), 309 H#{246}nack, see Lbscher, W., 1067 Gr#{248}n,P., see Kjeldsen, K., 721 rate changes and aldosterone release, Hori, M., see Ishihara, H., 388 Grondin, L., see Dewar, K. M., 696 adenosine-angiotensin II interac- Horiuchi, A., Iwatsuki, K., Yonekura, H. GTP-binding protein, atrial and ventricular tions (rats), 442 and Chiba, S.: Do D-1 dopamine re- contractile responses, somatostatin, sodium channel stimulation, calcium ceptors mediate dopamine-induced heart (guinea pigs), 726 channel blocking properties, PD pancreatic exocrine secretion in an- Guanine nucleotide binding proteins 122860 (rats), 22 esthetized dogs?, 734 gating of calcium channels Heart rate, mediation, serotonin receptors, Homer, E., see Pendleton, R. G., 31 fluoride, vascular smooth muscle (rats), m-chlorophenylpiperazine (rats), 72 Horohonich, S., see Kopia, G. A., 887 343 Heaslip, a. J. and Sickels, B. D.: Evidence Horohonich, S., see Ohistein, E. H., 548 1989 Index 1167

Hoskins, B., see Dulaney, M. D., Jr., 202 tors, cardiovascular actions (rats), Johnson, A. L., see Chiu, A. T., 867 Hough, L. B., see Gogas, K. R., 476 500 Johnson, K. M., see Ferkany, J. W., 100 Howell, R. E., Lanken, P. N., Hansen- Indomethacin Jones, A. W., see Post, J. M., 591 Flaschen, J. H., Haselton, F. R., Al- antihypertensive mechanism of captopril, Jones, B. E., see Ferkany, J. W., 100 belda, S. M. and Fishman, A. P.: Pal- renal hypertension (rats), 515 Jones, S. M., see Ferkany, J. W., 100 monary extraction of propranolol in defective modulation, noradrenergic neu- Josepovitz, C., see Ramsammy, L. S., 149 normal and oxygen-toxic sheep, 93 rotransmission, prostaglandins Jtmien, J. L., see Gue, M., 1006 Huidobro-Toro, J. P., see Salas, S. P., 992 (rats), 9 Jusko, W. J., see Nichols, A. I., 963 Human immunodeficiency virus, heroin glutathione depletion in kidney, vulnera- bility, thick ascending limb (rats), abusers and long-term methadone Kadowitz, P. J., see Neely, C. F., 170 247 maintenance, natural killer cell activ- Kainic acid, L-glutamate as neurotransmit- nordihydroguaritic acid or, blockade, ity, lymphocyte subsets, 606 ter, baroreceptor information, nu- EGF-induced uterine contractions Hutchison, A. J., see Bennett, D. A., 454 cleus of tractus solitarius (rats), 953 (rats), 882 Hydromorphone, opioid agonist/antagonist, Kalichman, M. W., Powell, H. C. and Inman, M., see Tuman, R. W., 836 drug discrimination, human postad- Myers, R. R.: Quantitative histologic 1,4,5-Inositol trisphosphate dicts, 184 analysis of local anesthetic-induced alpha-i adrenergic stimulation of forma- Hydroquinone, bone marrow stromal cell injury to rat sciatic nerve, 406 tion, ventricular myocytes (rats), regulation, B-lymphopoiesis (mice), Kaloyanides, G. J., see Ramsammy, L. S., 1141 582 149 ethanol and, calcium release, brain micro- 11-Hydroxy-8-tetrahydrocannabinol, di- Kalsner, S. and Quillan, M.: Nonneurogemc somes (mice), 875 methyl homologs, stereospecificity, relaxation to field stimulation in cor- Inouye, T., see Steinberg, S. F., 1141 discriminative stimulus functions onary arteries, 461 (rats, pigeons), 1000 Insulin diazoxide and cromakalim, inhibition by Kamenka, J.-M., see Koek, W., 1019 5-Hydroxytryptamine, see Serotonin Kamisaki, Y., see Kitamura, Y., 667 Hyman, A. L., see Neely, C. F., 170 gibenclamide (rabbits, rats), 261 -induced hypoglycemia, recovery, methyl Kanda, A., see Koyanagawa, H., 1092 Hynes, M. D., see Foreman, M. M., 227 palmoxirate effect (dogs), 836 Kanno, M., see Endou, M., 726 Hyperglycemia, diazoxide and cromakalim, ionic and secretory events, pancreatic is- Kanyicska, B., see Bagdy, G., 72 inhibition by glibenclamide (rabbits, lets, pinacidil and diazoxide (rats), Kaplan, L. M., see Steinberg, S. F., 1141 rats), 261 1011 Karaki, H., see Ishihara, H., 388 Hypertension Interleukin 1, induction of prostaglandin Kato, Y., see Ishihara, H., 388 decreased renal vascular responses, rise in biosynthesis, arachidonic acid lipox- Kaumann, A. J., see Frenken, M., 707 blood pressure, cyclosporine (rats), ygenation (rats), 714 Kawamoto, J. H., see Bennett, B. M., 316 1105 Intestine, contribution to first-pass metab- Kawasaki, K., see Ferkany, J. W., 100 defective modulation, noradrenergic neu- olism, felodipine (rats), 632 Kenakin, T. and Boselli, C.: Pharmacologic rotransmission, prostaglandins Ipsapirone, serotonin receptor subtypes, be- discrimination between receptor het- (rats), 9 havioral studies, anxiolytic drugs (pi- erogeneity and allosteric interaction: renal, antihypertensive mechanism, cap- goons), 809 Resultant analysis of gallamine and topril (rats), 515 Ischemia, cardiac sarcoplasmic reticulum, pirenzepine antagonism of musca- Hypoglycemia, insulin-induced, recovery, calmodulin, free oxygen radicals rinic responses in rat trachea, 944 methyl palmoxirate effect (dogs), 836 (dogs), 286 Ketamine Hypothalamus, changes in drinking activ- Ishihara, H., Ozaki, H., Sato, K., Hori, M., analgesic effects (monkeys), 197 ity, electrolyte excretion, diisopropyl- Karaki, H., Watabe, S., Kato, Y., Fu- behavioral effects ofphencyclidine analog fluorophosphate (rats), 202 setani, N., Hashimoto, K., Uemura, (mice, rats, pigeons), 1019 Hypoxia D. and Hartshorne, D. J.: Calcium- Ketanserin NMDA receptor-mediated neuronal in- independent activation of contractile electrophysiologic effects, Purkinje fibers, jury, delayed rescue, cortical culture apparatus in smooth muscle by caly- ventricular myocardium and heart (mice), 752 culin-A, 388 (dogs), 397 omeprazole metabolism, sulfone and sal- Islet-activating protein, atrial and ventric- serotonin receptor subtypes, behavioral fide metabolites, liver (rats), 1043 ular contractile responses, somato- studies, anxiolytic drugs (pigeons), pulmonary venule contractions, arachi- statin, heart (guinea pigs), 726 809 domc acid metabolites (guinea pigs), Isoproterenol, 02 consumption and coronary two populations of 5-hydroxytryptamine 1097 flow, beta adrenoceptor stimulation, receptors, basilar artery (dogs), 379 role of purines and xanthine oxidase, re- myocardium (dogs), 611 Kidney perfusion injury, liver (rats), 470 latin, N., see Macquin-Mavier, I., 740 changes in drinking activity and electro- Ito, H., see Okabe, E., 286 lyte excretion, diisopropylfluoro- Itoh, T., see Kitamura, Y., 667 Ibuprofen, defective modulation, noradre- phosphate (rats), 202 Itoh, T., see Shimizu, T., 659 nergic neurotransmission, prosta- cyclosporine A-induced vasoconstriction, luvone, P. M., see Zawilska, J., 86 glandins (rats), 9 mechanism (rats), 896 Iwatsuki, K., see Horiuchi, A., 734 IBZM, characterization of D2 receptors, decreased vascular responses, rise in caudate (dogs), 110 blood pressure, cyclosporine (rats), ICI 169,369, dimethylation, partial deacti- Jackson, E. K.: Defective modulation of nor- 1105 vator IC! 170,809, arterial 5-HT2 re- adrenergic neurotransmission by en- glutathione depletion, vulnerability, thick ceptor system (calves), 707 dogenous prostaglandins in aging ascending limb (rats), 247 ICS 205930, serotonin receptor subtypes, spontaneously hypertensive rats, 9 methotrexate transport, proximal tubule behavioral studies, anxiolytic drugs Jackson, E. K., see Holycross, B. J., 433,442 (rabbits), 688 (pigeons), 809 Jacobson, K. A., see Barone, S., 79 nephron, vanadate stimulation, N-ethyl- Idebenone, glutamate-induced cytotoxicity, Jameson, D. M., see Voelker, J. R., 772 maleimide-sensitive ATPase (rats), protection with antioxidants, neu- Jarbe, T. U. C., Hiltunen, A. J. and Mech- 529 ronal cells (mice), 1132 oulam, R: Stereospecificity of the purinergic vasoconstriction (rats), 764 Iga, T., see Nohjoh, T., 324 discriminative stimulus functions of renal hypertension, antihypertensive Iga, T., see Suzuki, H., 979 the dimethylheptyl homologs of 11- mechanism, captopril (rats), 515 Imipenem, transport in central nervous sys- hydrox-8-tetrahydrocannabinol in -selective dialkylxanthines, adenosine re- tem (rats), 979 rats and pigeons, 1000 ceptor prodrugs, 79 Impromidine, histamine H1 and H2 recep- Johanson, C. E., see Evans, S. M., 779 thiazide diuretic receptors, autoradi- 1168 Index Vol.250

ographic localization, metolazone L651,548, inhibition, bradykinin-induced hepatoprotective effects, cystathionine, (rats), 414 cytosolic calcium increase (dogs), 795 acetaminophen-induced necrosis urine composition, active furosemide frac- Labbe, G., Descatoire, V., Beaune, P., Let- (rats), 667 tion, nephrotic syndrome, 772 teron, P., Larrey, D. and Pessayre, liposome-mediated delivery, gadolinium- Kim, S. K., see Tadano, T., 254 D.: Suicide inactivation of cyto- diethylenetriaminopentaacetic acid, Kimura, T., see Koyanagawa, H., 1092 chrome P.450 by methoxsalen. Evi- 1113 Kimura, T., see Musha, T., 1087 dence for the covalent binding of a omeprazole metabolism, sulfone and sal- Kindling, amygdala-kindled rats, valproic reactive intermediate to the protein fide metabolites (rats), 1043 acid, 1067 moiety, 1034 peripheral-type benzodiazepine receptors, Kinemuchi, H., see Tadano, T., 254 Labbe, G., see Tinel, M., 746 solubilization, characterization King, A. G., Landreth, K. S. and Wierda, Lafontan, M., see Taouis, M., 1061 (rats), 1149 D.: Bone marrow stromal cell regu- Laird, H. E., II, see Parola, A. L, 1149 reperfusion injury, role, purines and ian- lation of B-lymphoboiesis. II. Mech- Landreth, K. S., see King, A. G., 582 thine oxidase (rats), 470 anisms ofhydroquinone inhibition of Landry, Y., see Gies, J.-P., 309 uptake of methotrexate, structural speci- pre-B cell maturation, 582 Landry, Y., see Mousli, M., 329 ficity (rats), 221 Locke, K. W., Gorney, B., Cornfeldt, M. and Kisara, K., see Tadano, T., 254 Lane, B. P., see Ramsammy, L S., 149 Kitada, Y., Kobayashi, M., Narimatsu, A. Lanken, P. N., see Howell, R E., 93 Fielding, S.: Characterization of the discriminative stimulus effects of and Ohizumi, Y.: Potent stimulation Larrey, D., see Labbe, G., 1034 physostigmine in the rat, 241 of myofilament force and adenosine Larrey, D., see Tine!, M., 746 Locus ceruleus, inhibition of synaptic pa- triphosphatase activity ofcanine car- Leatherman, D. L., see Middlebrook, J. L., tentials, serotonin agonists (rats), 37 diac muscle through a direct en- 860 Loeper, J. see Tinel, M., 746 hancement of troponin C Ca bind- Lebrun, P., Devreux, V., Hermann, M. and Lorazepam, intravenous, kinetic and dy- ing by MCI-154, a novel cardiotonic Herchuelz, A.: Similarities between namic study, diazepam comparison agent, 272 the effects of pinacidil and diazoxide on ionic and secretory events in rat (humans), 134 Kitamura, K., see Nishiye, E., 1079 pancreatic islets, 1011 Loscher, W., Fisher, J. E., Nau, H. and Kitamura, Y., Kamisaki, Y. and Itoh, T.: H#{246}nack,D.: Valproic acid in amyg- Hepatoprotective effects of cystathi- Leighton, H. J., see Ramagopal, M. V., 492 dala-kindled rats: Alterations in an- onine against acetaminophen-in- Leitman, D. C., see Bennett, B. M., 316 Lemasters, J. J., see Zhong, Z., 470 ticonvulsant efficacy, adverse effects duced necrosis, 667 Leone, C. and Gordon, F. J.: Is L-glutamate and drugand metabolitelevels in var- Kjeldsen, K. and Gr#{248}n,P.: Skeletal muscle ious brain regions during chronic Na,K-pump concentration in cM!- a neurotransmitter of barorecptor in- formation in the nucleus of the trac- treatment, 1067 dren and its relationship to cardiac tus solitarius?, 953 Luedtke, R. It, see Schonwetter, B. S., 110 glycoside distribution, 721 Letteron, P., see Labbe, G., 1034 Lung Kobayashi, M., see Kitada, Y., 272 Letteron, P., see Tinel, M., 746 basal activity, phosphatidic acid phospha- Koek, W., Colpaert, F. C., Woods, J. H. and Leukocytes tase (rats), 236 Kamenka, J.-M.: The phencydidine obesity and fat cell adrenoceptors (dogs), muscarinic receptors (humans, guinea (PCP) analog N-[1-(2-ben- pigs, 309 1061 rats), zol(B)thiophenyl)cyclohexyljpiperi- polymorphonuclear, degranulatory re- pulmonary extraction ofpropranolol, nor- dine shares cocaine-like but not other mal and oxygen-toxic sheep, 93 sponses, platelet-activating factor re- characteristic behavioral effects with ceptors (humans), 293 pulmonary venule contractions, hypoxia, PCP, ketamine and MK-801, 1019 arachidonic acid metabolites (guinea Leukotriene B4, formation by neutrophils, Kolhouse, J. F., see Deutsch, J. C., 221 glucocorticoid effects, chemotaxis, pigs), 1097 Komulainen, H., see Mannistroo, P. T., 1028 598 Luo, Z.-P., see Yang, X.-M., 358 Kopaciewicz, L. J., see Kopia, G. A., 887 Luteinizing hormone releasing hormone, Leukotrienes Kopia, G. A., Kopaciewicz, L J., Ohistein, blockade or EGF-induced uterine con- anterior pituitary and gonads! hor- E. H., Horohonich, S., Storer, B. L. mones, alcohol effects, women, 902 tractions, indomethacin, nordihydro- Lymphocytes, natural killer cell activity, and Shebuski, R J.: Combination of guaritic acid (rats), 882 the thromboxane receptor antago- parenteral heroin abusers, long-term pulmonary venule contractions, arachi- methadone maintenance, 606 nist, sulotroban (BM 13.177; Sk&F donic acid metabolites (guinea pigs), Lyon, R. A., see Gogas, K. R., 476 95587), with streptokinase: Demon- 1097 stration ofthrombolytic synergy, 887 Levame, M., see Macquin-Mavier, I., 740 Kornfeld, E. C., see Foreman, M. M., 227 Li, A. A., see Marek, G. J., 52,60 Macquin-Mavier, I., Levame, M., Istin, N. Koyanagawa, H., Musha, T., Kanda, A., Ki- Lidocaine, local anesthetic-induced injury, mura, T. and Satoh, S.: Inhibition of and Harm, A.: Mechanisms of endoth- sciatic nerve, histologic analysis elm-mediated bronchoconstriction in vagal transmission by cardiac sym- (rats), 406 the guinea pig, 740 pathetic nerve stimulation in the dog Liebman, J. M., see Bennett, D. A., 454 Macrolides, effects of clarithromycin, cyto- Possible involvement ofopioid recep- Liebson, I. A., see Preston, K. L, 184 chrome P-450 (rats), 746 tore, 1092 Liebson, I. A., see Heishman, S. J., 485 Macrophages, bone marrow stromal cell reg- Koyanagawa, H., see Musha, T., 1087 Liposomes, -mediated delivery, gadolinium- ulation, B-lymphopoiesis, hydroqui- Krause, D. N., see Friedman, D. J., 853 diethylenetriaminopentaacetic acid, none (mice), 582 Kreek, M. see Novick, D. M., 606 hepatic cells, 1113 Maggi, C. A., see Patacchini, R, 678 Kudlacz, E. M., Navarro, H. A. and Slotkin, Lipoxygenase, contractions of pulmonary Mailman, R. B., see Niedzwiecki, D. M., 126 T. A.: Phosphatidic acid phosphatase venules, induction by hypoxia and Mailman, R. B., see Niedzwiecki, S. M., 117 in neonatal rat lung Effects of pre- anoxia (guinea pigs), 1097 Mais, D. E., see Mayeux, P. R, 923 natal dexamethasone or terbutaline 5-Lipoxygenase, generation of endotheium- Major, T. C., see Haleen, S. J., 22 treatment on basal activity and on derived relaxing factor (dogs), 1055 Malfatto, G., see Zaza, Z., 397 responsiveness to beta-adrenergic Lippton, H., see Neely, C. F., 170 Malik, K. U., see Schwartz, D. D., 764 stimulation, 236 Little, H. J., see Dolin, S. J., 985 Mammalian cells, differential association, Kung, H. F., see Schonwetter, B. S., 110 Liver T-2 and T-2 tetraol, 860 Kung, M. P., see Schonwetter, B. S., 110 basolateral plasma membrane vesicles, M#{228}xmisth,P. T., Hanhij#{228}rvi, H., Havas, A., Kuriyama, H., see Nishiye, E., 1079 sodium, taurocholate uptake (rats), Vuorela, A., Komulainen, H. and Kurtzman, N. A., see Sabatini, S., 529, 910 301 Rauramaa, V.: Efficacy of erythro- Kwan, C. Y., see Shi, A. G., 1119 elimination of taurocholate and diaze- mycin acistrate (2’-acetyl erythro- Kyle, D. J., see Ferkany, J. W., 100 pam, models (rats), 1048 mycin stearate) and erythromycin 1989 Index 1169

stearate in experimental infections in hepatic uptake and biliary output, struc- ceptor binding and stimulated phos- mice, 1028 tural specificity (rats), 221 phoinositide-specific phospholipase Mansbach, R. S., see Gleeson, S., 809 transport by proximal tubule (rabbits), C in rabbit platelets, 831 Marchand, G. R, see Drewett, J. G., 428 688 Morse, W. H., see France, C. P., 928 Marek, G. J., Li, A. A. and Seiden, L S.: Methoxsalen, suicide inactivation, cyto- Mosig, D., see Besseghir, K., 688 Evidence for involvement of 5- chrome P-450 (rats), 1034 Mousli, M., Bronner, C., Bueb, J.-L., hydroxytryptainine1 receptors in an- N-Methyl-D-aspartic acid, L-glutamate as Tschirhart, E., Gies, J.-P. and Lan- tidepressant-like drug effects on dif- neurotransmitter, baroreceptor in- dry, Y.: Activation of rat perioneal ferential-reinforcement-of-low-rate formation, nucleus of tractus solitar- mast cells by substance P and mas- 72-second behavior, 60 isa (rats), 953 toparan, 329 Marek, G. J., Li, A. A. and Seiden, L. S.: Methyl-4-ethyl-6,7-dimethoxy--carboline- Mugridge, K. G., Donati, D., Silvestri, S. Selective 5-hydroxytryptamine-2 an- 3-carboxylate, behavioral evidence and Parente, L.: Arachidonic acid li- tagonists have antidepressant-likeef- for role of noradrenaline, anxiogenic poxygenation may be involved in in- fects on differential-reinforcement- actions (rats), 358 terleukin-l induction of prostaglan- of-low rate 72-second schedule, 52 Methyl palmoxirate, recovery from insulin- din biosynthesis, 714 Marquis, 0., Robaut, C. and Cavern, I.: Evi- induced hypoglycemia, diabetic dogs, Murad, F., see Bennett, B. M., 316 dence for the existence and ionic 836 Murphy, D. L., see Bagdy, G., 72 modulation ofplatelet-activating fac- Metolazone, autoradiographic localization, Murphy, T. H., see Miyamoto, M., 1132 tor receptors mediating degranula- thiaZide diuretic receptors (rats), 414 Muscle tory responses in human polymor- Microsomes, brain, calcium release, ethanol anococcygeus, postjunctional alpha-2 phonuclear leukocytes, 293 and l,4,5-inositol trisphosphate adrenoceptors (rats), 492 Martyn, J., see Tomera, J. F., 216 (mice), 875 cardiac, myofilament force and ATPase Mash, D. C., see Flynn, D. D., 573 Middlebrook, J. L. and Leatherman, D. L.: actiivty, MCI-l54 (dogs), 272 Masson, S., see Vion-Dury, J., 1113 Differential association ofT-2 tetraol gastrocnemius, intraperitoneal endo- Mast cells, peritoneal, activation, substance with mammalian cells, 860 toxin, D-tubocurarine dose-response P and mastoparan (rats), 329 Mihaly, G. W., see Angus, P. W., 1043 curves (mice), 216 Mayeux, P. R, Mais, D. E., Carr, C. and Miller, F. P., see Baron, B. M., 162 skeletal, Na,K-pump concentration, car- Halushka, P. V.: Human erythroleu- Minami, Y. and Toda, N.: Possible involve- disc glycoside distribution (humans), kemia cells express functional throm- ment of 5-lipoxygenase products in 721 boxane Ajprostaglandin H2 recep- the generation of endothelium-de- vascular, adrenoceptor mechanisms toys, 923 rived relaxing factor, 1055 (dogs), 1119 McCall, D. E., see Chiu, A. T., 867 Miyamoto, M., Murphy, T. H., Schnaar, R. Muscle, smooth McCarty, D. R, see Baron, B. M., 162 L and Coyle, J. T.: Antioxidants pro- activation of contractile apparatus, caly- McDonald, F. D., see Rossi, N. F., 891 tact against glutamate-induced cy- culin-A (rats, guinea pigs), 388 MCI-154, stimulation oftroponin C calcium toxicity in a neuronal cell line, 1132 vascular binding, ATPase activity, cardiac Miyata, K., see Shimizu, T., 654 calcium modulation of K efflux, BRL muscle (dogs), 272 MK-80l 34915 (rabbits), 591 McKinney, M., Anderson, D., Forray, C. and analgesic effects (monkeys), 197 G-proteins, gating of calcium channels El-Fakahany, E. E.: Characterization behavioral effects ofphencycidine analog (rats), 343, 352 striatal ofthe M2 muscarinic receptor (mice, rats, pigeons), 1019 nonpeptide angiotensin il receptor an- mediating inhibition of cyclic AMP NMDA receptor-mediated neuronal in- tagonists (rats), 867 using selective antagonists: A com- jury, delayed rescue, cortical culture Musha, T., Satoh, E., Koyanagawa, H., Ki- parson with the brainstem M2 recep- (mice), 752 mum, T. and Satoh, S.: Effects of tor, 565 Molinoff, P. B., see Schonwetter, B. S., 110 opioid agonists on sympathetic and Monoamine oxidase, inhibition of type A in MDL 72222, serotonin receptor subtypes, parasympathetic transmission to the behavioral studies, anxiolytic drugs brain, para-hydroxyamphetamine- dog heart, 1087 induced head-twitch response (mice), (pigeons), 809 Musha, T., see Koyanagawa, H., 1092 Mechoulam, R, see J#{227}rbe,T. U. C., 1000 254 Myers, It R., see Kalichman, M. W., 406 Meclofenamate, cyclosporine A-induced Monoamine oxidase inhibitors, 5- Myocardium renal vasoconstriction, mechanism hydroxytryptamine1 receptors, anti- coronary flow during beta adrenoceptor (rats), 896 depressant-like drug effects (rats), 60 stimulation, regional 02 consumption see 301 Monoclonal antibodies, angiotensin II, cap- Meier, P. J., Zimmerli, B., (dogs), 611 Melatonin, content of retina and pineal topril, renal hypertension (rats), 515 ventricular, electrophysiologic effects, ke- gland, catecholamine receptors Montastruc, P., see Taouis, M., 1061 tanserin (dogs), 397 (chicken), 86 Montreal!, B., see Dewar, K. M., 696 Myocytes Mordhortst, M., see Coyne, D. W., 795 Meli, A., see Patacchini, R., 678 ventricular Mello, N. K., see Mendelson, J. H., 902 Morgan, D. J., see Angus, P. W., 1043 a4tha-l stimulation, 1,4,5-inositol tris- Mendelson, J. H., Mello, N. K.. Teoh, S. K. Morgan, D. J., see Ching, M. S., 1048 phosphate formation (rats), 1141 and Ellingboe, J.: Alcohol effects on Morphine ATP-sensitive potassium current, ni- luteinizing hormone releasing hor- discriminative stimulus effects, naltrex- corandil (guinea pigs, rabbits), 278 mone-stimulated anterior pituitary one (monkeys), 937 reduction of outward currents, alpha and gonadal hormones in women, 902 effects of opioid agonists, sympathetic adrenoceptor stimulation (rats), 364 Meningitis, cefodizime transport, choroid and parasympathetic transmission, plexus (rats), 324 heart (dogs), 1087 Mercer, W. D., see Novick, D. M., 606 -naloxone interval variation, acute opioid N-0437, prejunctional inhibitory effect, vas- Mermet, C., see Tibirica, E., 642 physical dependence (humans), 485 cular adrenergic responses (rats), 853 Mesoridazine potency of infused spinal antinociceptive Nakamura, M., see Shimizu, T., 654,659 thioridazine and sulforidazine agents, magnitude of tolerance, con- Nakao, K., see Nishiye, E., 1079 anticholinergicproperties (rabbits), 126 tinuous infusion (rats), 1 Nakatsu, K., see Bennett, B. M., 316 antidopaminergic properties, corpus withdrawal, acetylcholine and a-amino- Nakaya, H., see Endou, M., 726 striatum (rabbits), 117 butyric acid outflow, alpha receptors Nalbuphine, opioid agonist/antagonist, Methadone, long-term maintenance, natu- (guinea pigs), 682 drug discrimination, human poetad- ral killer cell activity, lymphocyte Morrison, A. R, see Coyne, D. W., 795 diets, 184 subsets, 606 Morrison, W. J. and Shukla, S. D.: Antago- Naloxone Methotrexate nism of platelet activating factor re- cortical acetylcholine and GABA outflow, 1170 Index Vol.250

morphine withdrawal, aLpha recep- Niedzwiecki, D. M., Cubeddu, L X. and activation of the spinal serotonergic tors (guinea pigs), 682 Mailman, R. B.: Comparative anti- system in the rat by phencycidine in effects of opioid agonists, sympathetic cholinergic properties of thionidazine, vitro, 177 and parasympathetic transmission, mesoridazine and sulforidazine, 126 Okabe, E., Sugihara, M., Tanaka, K., Sa- heart (dogs), 1087 Nishiye, E., Nakao, K., Kitamura, K. and saki, H. and Ito, H.: Calmodulin and -morphine interval variation, acute opioid Kuriyama, H.: Inhibitory actions of a free oxygen radicals interaction with physical dependence (humans), 485 novel benzothiazepine deniavative, steady-state calcium accumulation Naltrexone TA3090, on the electrical and me- and passive calcium permeability of discriminative stimulus effects, morphine chanical responses ofthe rabbit mes- cardiac sarcoplasmic reticulum, 286 treatment (monkeys), 937 enteric artery, 1079 Omeprazole, clearance, oxygen dependence, supersensitivity, pharmacological charac- Nohjoh, T., Suzuki, H., Sawada, Y., Sugi- liver (rats), 1043 terization (monkeys), 928 yama, Y., Iga, T. and Hanano, M.: Opiates, tolerance to respiratory actions, su- Narimatsu, A., see Kitada, Y., 272 Transport of cefodizime, a novel fent,anil (rats), 371 Natural killer cells, lymphocyte subsets, third generation cephalosponin anti- Opioids parenteral heroin abusers, long-term biotic, in isOlated rat choroid plexus, acute physical dependence, variation, methadone maintenance, 606 324 morphine-naloxone interval (hu- Nau, H., see Loscher, W., 1067 Noradrenaline mans), 485 Navarro, H. A., see Kudlacz, E. M., 236 alpha adrenoceptor stimulation, reduction agonist/antagonist, drug discrimination, Neely, C. F., Kadowitz, P. J., Lippton, H., of outward currents, ventricular my- human postaddicts, 184 Neiman, M. and Hyman, A. L.: Aden- ocytes (rats), 364 antinociception, role, histamine and H,- osine does not mediate the pulmo- behavioral evidence, anxiogenic actions, receptors (rats), 476 nary vasodilator response of adeno- benzodiazepine receptor agonist central and peripheral, modulation of gas- sine 5’-triphbsphate in the feline pul- (rats), 358 tric relaxation, feeding (dogs), 1006 monary vascular bed, 170 Nor-binaltrophimine, conditional fear-in- diuretic effect of bremazocine (rats), 992 Neiman, M., see Neely, C. F., 170 ducedanalgesia, opioid mu and kappa potency of infused spinal antinociceptive Neostriatum, raclopride kinetics and distri- receptors (rats), 825 agents, magnitude of tolerance, con- bution, dopamine D2 receptors (rats, Nordihydroguanitic acid, indomethacin or, tinuous infusion (rats), 1 rabbits), 696 blockade, EGF-induced uterine con- Organophosphorus agents, SAD-128, nico- Nephron, vanadate stimulation, N-ethyl- tractions (rats), 882 tinic acetylcholine receptor kinetics maleimide-sensitive adenosine tn- Norepinephnine (frogs), 842 phosphate (rats), 529 adrenergic agonists and Na-K-ATPase, Ouabain, skeletal muscle Na,K-pump con- Nephrotic syndrome, urine composition, ac- proximal tubules, basolateral mem- centration, cardiac glycoside distri- tive fuoresmide fraction, 772 branes (rabbits), 672 bution, children, 721 adrenoceptor mechanisms, vascular tis- Nephrotoxicity, gentamicin, protection; pa- Oxygen lyaspartic acid (rats), 149 sues (dogs), 1119 omeprazole clearance, sulfone and sulfide blood vessel response, neuropeptide Y, Nerve, peniartenial, puninergic vasoconstric- metabolites, liver (rats), 1043 tion (rats), 764 sympathetic field stimulation (nab- regional consumption, coronary flow, beta bits), 523 adrenoceptor stimulation (dogs), 611 Neurochemistry, corticotropin-releasing factor, schedule-controlled behavior defective modulation, noradrenergic neu- toxicity, pulmonary extraction, propran- rotransmission, prostaglandins olol, 93 (pigeons), 788 (rats), 9 Oxygen radicals, calmodulin and, calcium Neuronal cells, protection with antioxi- mediation of inhibitory effect by cyclic accumulation, cardiac sarcoplasmic dant.s, glutamate-induced cytotoxic- GMP, atrial natriuretic factor, pheo- reticulum (dogs), 286 ity (mice), 1132 chromocytoma cells, 428 Ozaki, H., see Ishihara, H., 388 NeuropeptideY, blood vessel response, nor- NMDA receptor site, competitive iaMbi- epinephrine, sympathetic field stim- tore, nucleotides (rats), 162 ulation (rabbits), 523 guanine prejunctional inhibitory effect of N-0437, Pancreas Neurotoxicity, NMDA receptor-mediated vascular adrenergic responses (rats), exocrine secretion, D-1 dopamine recep- neuronal injury, delayed rescue, con- 853 tors (dogs), 734 tical culture (mice), 752 Novick, D. M., Ochshorn, M., Ghali, V., ionic and secretory events, pinacidil and Neurotransmission Croxson, T. S., Mercer, W. D., Chior- diazoxide (rats), 1011 noradrenergic azzi, Nand Kreek M. J.: Natural Pang, P. K. T., see Zeng, Y. Y., 343, 352 adenosine-angiotensin II interactions, killer cell activity and lymphocyte Para-hydroxyamphetamine, -induced head- vasoconstniction (rats), 433 subsets in parenteral heroin abusers twitch response, inhibition of mono- defective modulation, prostaglandins and long-term methadone mainte- amine oxidase type A, brain (mice), (rats), 9 nance patients, 606 254 Neurotransmitter, Lglutamate, barorecep- NPC 12626, pharmacological profile (rats, Parente, L, see Mugnidge, K. G., 714 ton information, nucleus of tractus mice, gerbils), 100 Panini, A., see Podevin, R.-A., 672 solitarius (rats), 953 Nuclear magnetic resonance, liposome-me- Parola, A L, Putnam, C. W., Russell, D H. Neutrophils, leukbtniene B4 formation, glu- diated delivery to hepatic cells, gad- and Laird, H. E., II: Solubilization cocorticoideffects, chemotaxis, 598 oliniuin-diethylenetriaminopentaa- and characterization of liver periph- Newland, M.. C., see Cory-Slechta, D. A., cetic acid, 1113 eral-type benzodiazepine receptor, 800 1149 Nichols, A. I.,.D’Ambrosio, R., Pyszczynski, Parsons, M. E., see Gogas, K. It, 476 N. A. and Jusko, W. J.: Pharmaco- Obesity Patacchini, R., Maggi, C. A., Rovero, P., kinetics and pharmacodynamics of modification ofadrenergic status,adipose Regoli, D., Drapeau, G. and Mcli, A.: prednisolone in obese rats, 963 tissue (dogs), 1061 Effect of thiorphan on tachykinin- Nichols, C. L, see Foreman, M. M., 227 pharmacokinetics and pharmacody- induced potentiation of nerve-me- 2-Nicotinamidoethyl nitrate, ATP-sensitive namics, prednisolone (rats), 963 diatedcontractions ofthe rat isOlated potassium current, ventricular my- Ochahorn, M., see Novick, D. M., 606 vas deferens, 678 ocytas (guinea pigs, rabbits), 278 Ohizumi, Y., see Kitada, Y., 272 Patch-clamp technique, activation of ATP- Niedzwiecki, D. M., Cubeddu, L. X. and Ohistein, E. H., Horohonich, S. and Hay D. sensitive potassium current, nicor- Mailman, R. B.: Comparative anti- W. P.: Cellular mechanisms of en- andil, ventricular myocytes (guinea dopaminergic properties of thiorida- dothelin in rabbit aorta, 548 pigs, rabbits), 278 zinc, mesoridazine and sulfonidazine Ohlatein, E. H., see Kopia, G. A., 887 Paterson, N. A. M., see Tracey, W. R., 1097 on the corpus stniatum, 117 Ohno, Y. and Warnick, J. E.: Presynaptic Pauli, G., see Gies, J.-P., 309 1989 Index 1171

PD 122860, sodium channel stimulation, Pineal gland, melatonin content, catechol- acute and chronic phencydidine admin- calcium channel blocking properties amine receptors (chicken), 86 istration (rats), 534 (rats), 22 Ping, L., see Holycross, B. J., 442 alcohol effects in women, 902 Pearson, A. A., Gaffney, T. E., Walle, T., Pirenzepine, muscarinic receptors (humans, blood pressure mediation, serotonin re- and Privitera, P. J.: A stereoselective guinea pigs, rats), 309 ceptors, m-chlorophenylpiperazine central hypotensive action of ateno- Pirenzipine, gallamine and, antagonism of (rats), 72 lol, 759 muscarinic responses, trachea (rats), preclinical studies of quinelorane (rats), Pechnick, R N., George, R, Poland, R. E, 944 227 Hiramatsu, M. and Cho, A. K.: Char- Pitts, B., see Sybertz, E. J., 624 Propranolol, pulmonary extraction, normal acterization ofthe effects ofthe acute Plasma membrane, basolateral liver vesi- and oxygen-toxic sheep, 93 and chronic administration of phen- des, sodium, taurocholate uptake Prostaglandin F,, comparison of contrac- cycidine on the release of adrenocor- (rats), 301 tions, contractile agonists, stomach ticotropin, corticosterone and prolac- Plasminogen activator, acetylation of fi- fundus (rats), 971 tin in the rat: Evidence for the differ- bninogen by aspirin, enhanced fibri- Prostaglandin H,, functional receptors, ential development of tolerance, 534 nolysis (humans), 154 HEL cells, 923 Pechnick, B. N., see Cho, A. K., 210 Platelet-activating factor Prostaglandins aorta contraction, protein kinase Pendleton, R. G., Gessner, G. and Homer, antagonism of receptor binding, phos- C-dc- E.: Studies defining minimal receptor phoinositide-specific phospholipase pendent mechanism (rats), 44 domains for angiotensin II, 31 C (rabbits), 831 biosynthesis, interleukin 1 induction, ar- achidomc acid lipoxygenation (rats), Pentazocine modulation of receptors, degranulatory 714 effects of opioid agomsts, sympathetic responses, polymorphonuclear leu- blockade or EGF-induced uterine con- and parasympathetic transmission, kocytes (humans), 293 tractions, indomethacin, nordihydro- heart (dogs), 1087 Platelets, obesity and fat cell adrenoceptors guaritic acid (rats), 882 opioid agonist/antagonist, drug discnimi- (dogs), 1061 defective modulation, noradrenergic neu- nation, human postaddicts, 184 Podevin, R-A. and Parini, A.: Adrenergic rotransmission (rats), 9 Pergolide, autoradiographic assessment, Dl agonists and the Na-K-adenosine Protein, malnutrition, intraperitoneal endo- dopamine agonist effects (rats), 1156 triphosphatase from rabbit proximal toxin, D-tubocurarine and gastroc- Pessayre, D., see Labbe, G., 1034 tubules and their basolateral mem- nemius muscle (mice), 216 Pessayre, D., see Tine!, M., 746 branes, 672 Protein kinase C, -dependent mechanism, Peters, S. P., see Schleimer, R. P., 598 Poland, R E., see Pechnick, R. N., 534 prostaglandins, aorta contraction Phencydidine Polyaspartic acid, protection against genta- (rats), 44 acute and chronic administration, endo- micin nephrotoxicity (rats), 149 Proximal tubules crine function (rats), 534 Porter, A. C., see Dulaney, M. D., Jr., 202 adrenergic agonists and Na-K-ATPase, behavioral effects ofphencycidine analog Post, J. M., Smith, J. M. and Jones, A. W.: basolateral membranes (rabbits), 672 (mice, rats, pigeons), 1019 BRL 34915 (cromakalim) stimula- methotrexate transport (rabbits), 688 decadeutero variant and, pharmacoki- tion of4’K efflux from rabbit arteries Pugsley, T. A., see Haleen, S. J., 22 netic and pharmacodynamic evalua- is modulated by calcium, 591 Punines, xanthine oxidase and, reperfusion tion (rats), 210 Potassium, efflux from arteries, BRL 34915 injury, liver (rats), 470 -like drugs, analgesic effects (monkeys), stimulation, calcium modulation Purkinje fibers, electrophysiologic effects, 197 (rabbits), 591 ketanserin (dogs), 397 presynaptic activation, spinal serotoner- Potassium channel, diazoxide and cromak- Putnam, C. W., see Parola, A. L, 1149 gic system (rats), 177 alim, inhibition by glibenclamide Pyridylethylamine, histamine H1 and H, re- Phencydidine analog, N-[1-(2- (rabbits, rats), 261 ceptors, cardiovascular actions (rats), benzo(B)thiophenyl)cyclohexyl)pi- Potassium current 500 peridine, behavioral effects (mice, ATP-sensitive, nicorandil, ventricular Pyszczynski, N. A., see Nichols, A. I., 963 rats, pigeons), 1019 myocytes (guinea pigs, rabbits), 278 Phenylalanine, minimal receptor domains, reduction of outward currents, alpha ad- Quast, U. and Cook, N.S.: In vitro and in angiotensin II (rabbits), 31 renoceptor stimulatiop, ventricular vivo comparison of two K channel Phenylephrine, adrenoceptor mechanisms, myocytes (rats), 364 openers, diazoxide and cromakalim, vascular tissues (dogs), 1119 Poulakos, J. J. and Gertner, S. B.: Studies and their inhibition by glibenclam- Phenytoin, teratogenicity, 1,3-bis(2-chloro- on the cardiovascular actions of cen- ide, 261 ethyl)-1-nitrosourea, embryonic glu- tral histamine H1 and H, receptors, Quillan, see Kalsner, S., 461 tathione reductase (mice), 336 500 Quinacrine, cyclosporine A-induced renal Pheochromocytoma cells, mediation of Powell, H. C., see Kalichman, M. W., 406 vasoconstriction, mechanism (rats), inhibitory effect, atrial natriuretic Prazosin, adrenoceptor mechanisms, vas- 896 factor, cyclic GMP, 428 cular tissues (dogs), 1119 Quinelorane, predinical studies (rats), 227 Phosphatidic acid phosphatase, basal activ- Prednisolone, pharmacokinetics and phar- Quisqualate, glutamate-induced cytotoxic- ity, beta-adrenergic stimulation macodynamics, obesity (rats), 963 ity, protection with antioxidants, (rats), 236 Preston, K. L., Bigelow, G. E., Bickel, W. neuronal cells (mice), 1132 Phosphoinositide K. and Liebson, I. A.: Drug discnimi- muscarinic receptor-stimulated metabo- nation in human postaddicts: Ago- Raclopride, kinetics and distribution, dope- lism, ethanol, brain development nist-antagonist opioids, 184 mine D, receptors, brain (rats, rab- (rats), 541 Price, W. A., Jr., see Chiu, A. T., 867 bits), 696 turnover, endothelin cellular mecha- Price, W. A., see Wong, P. C., 515 Raiteri, M., Bonanno, G. and Fedele, E.: nisms, aorta (rats), 548 Privitera, P. J., see Pearson, A. A., 759 Release of y-[’H]amipobutyric acid Phospholipase C, phosphoinositide-specific, Probenecid, methotrexate transport, proxi- (GABA) from electrically stimulated antagonism,platelet activating factor mal tubule (rabbits), 688 rat cortical slices and its modulation receptor binding (rabbits), 831 Procaine, local anesthetic-induced injury, by GABA8 autoreceptors, 648 Phthalate acid esters, effect on transport in sciatic nerve, histologic analysis Ramagopal, M. V. and Leighton, H. J.: bladder membrane (toads), 910 (rats), 406 Analysis of the presence of postjunc- Physostigmine, discriminative stimulus ef- Prodrugs, adenosine receptor, kidney-selec- tional ajpha-2 adrenocptors in the fects (rats), 241 tive dialkylxanthines, 79 rat anococcygeus musde,. 492 Pinacidil, diazoxide and, ionic and secretory Progesterone, alcohol effects in women, 902 Ramsammy, L. S., Josepovitz, C., Lane, B. events, pancreatic islets (rats), 1011 Prolactin P. and Kaloyarndes, G. J.: 1172 Index Vol.250

tic acid protects against gentamicin stimulus effects, physostigmine Kurtzman, N. A.: Effect of phthalate nephrotoxicity in the rat, 149 (rats), 241 acid esters on transport in toad blad- Rauramaa, see MAnnistro#{246}, P. T., 1028 muscarinic M,, cyclic AMP inhibition, den membrane, 910 Rauwolscine, adrenoceptor mechanisms, brainstem and stniatum (rats), 565 Sabatini, S. and Kurtzman, N. A.: Vanadate vascular tissues (dogs), 1119 nicotinic acetylcholine, kinetics, SAD-128 stimulates the N-ethylmaleimide- Ravens, U., Wang, X.-L. and Wettwer, E.: (frogs), 842 sensitive adenosine triphosphatase in alpha adrenoceptor stimulation re- opioid kappa, serotonin and tolerance, U- rat nephron, 529 duces outward currents in rat yen- 50,488H (mice), 508 Sacaan, A. I., see Ferkany, J. W., 100 tricular myocytes, 364 opioid mu and kappa, conditional fear- SAD-l28, alteration of kinetic properties, Reader, T. A., see Dewar, K. M., 696 induced anlgesia (rats), 825 nicotinic acetylcholine receptor ion Receptors platelet-activating factor channel (frogs), 842 adenosine antagonism, phosphoinositide-specific Salas, S. P., Roblero, J., Ureta, H. and Hm- prodrugs, kidney-selective dialkylian- phosphoipase C (rabbits), 831 dobro-Toro, J. P.: Diuretic effect of degranulatory responses, polymorpho- thines, 79 bremazocine, a kappa-opioid with purine antinociception, spinal cord nuclear leukocytes (humans), 293 central peripheral sites of action, 992 (rats), 915 prostaglandin H,, HEL cells, 923 Sarcoplasmic reticulum, cardiac, calmodu- adrenergic, Na-K-ATPase, proximal purinergic in, free oxygen radicals (dogs), 286 pulmonary vasodilator response, aden- tubules and basolateral membranes Sasaki, H., see Okabe, E, 286 osine (cats), 170 (rabbits), 672 Sato, K., see Ishihara, H., 388 renal periarterial nerve stimulation, angiotensin II, minimal receptor domains Satoh, E., see Musha, T., 1087 vasoconstniction (rats), 764 (rabbits), 31 Satoh, N., see Tadano, T., 254 serotonin benzodiazepine Satoh, S., see Koyanagawa, H., 1092 antinociception, U-50,488H (mice), 508 Satoh, S., see Musha, T., 1087 agonist, noradrenaline and anxiogenic behavioral studies, anxiolytic drugs (pi- Satoh, S.-E., see Tadano, T., 254 actions (rats), 358 geons), 809 Sawada, Y., see Nohjoh, T., 324 liver peripheral-type, solubilization blood pressure mediation, m-chloro- Sawada, Y., see Suzuki, H., 979 (rats), 1149 phenylpiperazine (rats), 72 catecholamine, melatonin content, retina Scavone, J. M., see Greenblatt, D. J., 134 two populations, basilar artery (dogs), SCH 39370, atnial natriu.retic factor re- and pineal gland (chicken), 86 379 sponses, desoxycorticosterone ace- dopamine Dl, pancreatic exocrine secre- thromboxane A,, HEL cells, 923 tate-sodium hypertensive rats, 624 tion (dogs), 734 Reflex Schaus, J. M., see Foreman, M. M., 227 dopamine D2 baroreceptor, L-glutamate, neurotrans- Schleizner, R. P., Freeland, H. S., Peters, S. prejunctional inhibitory effect, N-0437 mitter (rats), 953 P., Brown, K. E. and Derse, C. P.: An (rats), 853 monosynaptic, spinal serotonergic sys- assessment of the effects of glucocor- raclopride kinetics, brain (rats, rab- tem, phencyclidine (rats), 177 ticoids on degranulation, chemotaxis, bits), 696 Regrdh, C. G., see Wang, S.-X., 632 binding to vascular endotheium and radioligand binding assay, caudate Regoli, D., see Patacchini, R., 678 formation of leukotriene B4 by pun- (dogs), 110 Reilly, T. M., see Wong, P. C., 515 fled human neutrophils, 598 dopamine Dl and D2, behavioral differ- Respiration, tolerance, sufentanil (rats), 371 Schmidt, C. J., see Baron, B. M., 162 entiation, stimulus properties (rats), Retina, melatonin content, catecholamine Schnaar, R. L, see Miyamoto, M., 1132 800 receptors (chicken), 86 Schneider, D. E., see Bjornsson, T. D., 154 histamine H,, role, opioid antinociception Reynolds, I. J., see Baron, B. M., 162 Schnepper, P. W., see Chen, J.-C., 141 (rats), 476 Ribosomes, differential association of T-2 Schoepp, D. D., see Secrest, It J., 971 histamine H, and H,, cardiovascular ac- and T-2 tetnaol, mammalian cells, Schonwetter, B. S., Luedtke, R. R., Kung tions (rats), 500 860 M. P., Billings, J., Kung, H. F. and Ritanserin, serotonin receptor subtypes, be- 5-hydroxytryptamine,, antidepressant- Molinoff, P. B.: Characterization of havioral studies, anxiolytic drugs (pi- like drug effects (rats), 60 membrane-bound and soluble D2 re- 5-hydroxytryptamine,, dimethylation of geons), 809 ceptors in canine caudate using [1Th1) Robaut, C., see Marquis, 0., 293 IC! 169,369 (calves), 707 -IBZM, 110 Robinson, R. B., see Steinberg, S. F., 1141 5-hydroxytryptaminel and 5-HT1B, in- Schr#{246}der, H., see Bennett, B. M., 316 Roblero, J., see Salas, S. P., 992 hibited synaptic potentials, locus cer- Schwann cells, local anesthetic-induced in- Roch-Ramel, F., see Besseghir, K., 688 uleus (rats), 37 jury, sciatic nerve, histologic analysis Rockhold, R. W., see Dulaney, M. D., Jr., N-methyl-D-aspartate (rats), 406 202 antagonist, NPC 12626 pharmacologi- Schwartz, D. D. and Malik, K. U.: Renal Rodriguez, J. V., see Torres, A. M., 247 cal profile (rats, mice, gerbils), 100 peniartenial nerve stimulation-in- Rosen, M. R., see Zaza, Z., 397 behavioral pharmacological profile, duced vasoconstniction at low fre- Rossi, N. F., Churchill, P. C., McDonald, F. CGS 19755 (mice), 454 quencies is primarily due to release D. and Ellis, V. R.: Mechanissm of competitive inhibitors, guanine nucleo- ofa puninergic transmitter in the rat, cyclosporine A-induced renal yam- tides (rats), 162 764 constriction in the rat, 891 neuronal injury, delayed rescue (mice), Sciaky, M., see Vion-Dury, J., 113 Rovero, P., see Patacchini, R., 678 752 Secrest, R. J., Schoepp, D. D. and Cohen M. RU 24969, serotonin receptor subtypes, be- presynaptic activation by phencycli- L.: Comparison ofcontractions to se- drugs (pi- dine, spinal serotonergic system havioral studies, anxiolytic geons), 809 rotonin, carbamylcholine and pros- (rats), 177 Rubidium, ionic and secretory events, pan- taglandin F,, in rat stomach fundus, muscaninic creatic islets, pinacidil and di.zoxide 971 endogenous acetylcholine release, neo- (rats), 1011 Seiden, L. S., see Merck, G. J., 52, 60 striatal slices (rats), 617 Serotonin Russell, D. H., see Parola, A. L, 1149 gallamine and pirenzipine antagonism, Rzeszotarski, W. J., see Ferkany, J. W., 100 agonists, inhibited synaptic potentials, lo- trachea (rats), 944 cus ceruleus (rats), 37 lung (humans, guinea pigs, rats), 309 comparison of contractions, contractile phosphoinositide metabolism, ethanol 5-8666 agonists, stomach fundus (rats), 971 and brain development (rats), 541 . additive diuretic effect, furosemide-in- 5-hydroxytryptamine, receptors, differ- subtype regulation, tetrahydroami- duced diuresis (rats), 659 ential-reinforcement-of-low-rate 72- noacridine (rats), 573 urinary calcium excretion (rats), 654 sec behavior (rats), 60 muscarmnic cholinergic, discriminative Sabatini, S., Fracasso, A., Bazzato, G. and increased efflux, partially oxidized sero- 1989 Index 1173

tonin, 4,5-diketotryptamine (rats), A, adenosine receptors mediating the antidopaminergic properties, corpus 141 punine antinociception, motor and stniatum (rabbits), 117 -induced increase in carotid sinus nerve autonomic function in the rat spinal Sulotroban, combined with streptokinase, activity, GR38032F (rats), 637 cord, 915 thrombolytic synergy (dogs), 887 involvement in antinociception, toler- Spalluto, P., see Beani, L., 682 Sutfm, T. A., see Wang, S.-X., 632 ance, U-50,488H (mice), 508 Spector, R., see Suzuki, H., 979 Suzuki, H., Sawada, Y, Sugiyama, Y., Iga, presynaptic activation, phencydidine, Spinal cord T., Hanano, M. and Spector, R.: spine (rats), 177 potency of infused spinal antinociceptive Transport of imipenem, a novel car- pulmonary extraction ofpropranolol, nor- agents, magnitude of tolerance, con- bapenem antibiotic, in the rat central mal and oxygen-toxic sheep, 93 tinuous infusion (rats), 1 nervous system, 979 receptor subtypes, behavioral studies, role of A1/A, adenosine receptors, purine Suzuki, H., see Nohjoh, T., 324 anxiolytic drugs (pigeons), 809 antinociception (rats), 915 Sybertz, E. J., Chiu, P. J. S., Vemulapalli, selective 5-hydroxytryptamine-2 antago- serotonergic system, presynaptic activa- S., Pitts, B., Foster, C. J., Watkins, nists, antidepressant-like effects, dif- tion, phencycidine (rats), 177 R W., Barnett, A. and Haslanger, M. ferential-reinforcement-of-low rate Spiperone, serotonin receptor subtypes, be- F.: SCH 39370, a neutral metalloen- dopeptidase inhibitor, potentiates bi- 72-sec schedule (rats), 52 havioral studies, anxiolytic drugs (pi- ological responses to atrial natri- Serotonin N-acetyltransferase, melatonin geons), 809 uretic factor and lowers blood pres- content, catecholamine receptors, Stancel, G. M., see Gardner, R M., 882 sure in desoxycorticosterone acetate- retina and pineal gland (chicken), 86 Staphylococcus aureus, efficacy of erythro- sodium hypertensive rats, 624 Shader, R. I., see Greenblatt, D. J., 134 mycin acistrate, erythromycin stear- Szemeredi, K., see Bagdy, G., 72 Shebuski, R. J., see Kopia, G. A., 887 ate (mice), 1028 SM, A. G., Kwan, C. Y. and Daniel, E. E.: Steffen, R. P., see Haleen, S. J., 22 T-2, T-2 tetraol and, differential associa- Rejation between (maximum bind- Steinberg, S. F., Kaplan, L. M., Inouye, T., tion, mammalian cells, 860 ing) of alpha adrenoceptor binding Zhang, J. F. and Robinson, R. B.: TA3090, inhibitory actions, electrical and sites and contractile response in four alpha-i adrenergic stimulation of 1, mechanical response8, mesentenic ar- canine vascular tissues, 1119 4,5-inositol trisphosphate formation tery (rabbits), 1079 Shimizu, T., Itoh, T. and Nakamura, M.: in ventricular myocytes, 1141 Tachykinin, -induced potentiation of nerve- Additive diuretic effect of 5-8666 Stevens, C. W., see Sosnowski, M., 915 mediated contractions, thiorphan ef- during furosemide-induced diuresis Stevens, C. W and Yaksh, T. L.: Potency of fect, vas deferens (rats), 678 in rats, 659 infused spinal antinociceptive agents Tadano, T., Satoh, S.-E., Satoh, N., Kisara, Shimizu, T., Miyata, K. and Nakamura, M.: is inversely related to magnitude of K., Anal, Y., Kim, S. K. and Kine- Effect of 5-8666 on urinary Ca ex- tolerance after continuous infusion, muchi, H.: Potentiation of para-hy- cretion in rats, 654 1 droxyamphetamine-induced head- Shukla, S. D., see Morrison, W. J., 831 Stitzer, M. L., see Heishman, S. J., 485 twithh response by inhibition of Sickels, B. D., see Heaslip, R. J., 44 Stomach monoamine oxidase type A in the Silvestri, S., see Mugridge, K. G., 714 arachidonic acid lipoxygenation, interleu- brain, 254 Simonato, M., see Beani, L, 682 kin 1 induction, prostaglandin bio- Tai, N. T., see Greenblatt, D. J., 134 Sircar, I., see Haleen, S. J., 22 synthesis (rats), 714 Takemoni, A. E., see Ho, B. Y., 508 Sivam, S. P.: Cocaine selectivity increases fundus, comparison, contractile agonists Tanaka, K., see Okabe, E., 286 stniatonigral dynorphin levels by a (rats), 971 Tanganelli, S., see Beani, L., 682 dopaminergic mechanism, 818 Storer, B. L, see Kopia, G. A., 887 Taouis, M., Valet, P., Estan, L, Lafontan, SKF 38393, dopaminergic Dl and D2 ago- Streptococcuspneumoniae, efficacy of eryth- M., Montastruc, P. and Berlan, M.: iiists, behavioral differentiation, romycin acistrate, erythromycin Obesity modifies the adrenergic sta- stimulus properties (rats), 800 stearate (mice), 1028 tus of dog adipose tissue, 1061 SKF 95587, combined with streptokinase, Streptokinase, combined with sulotroban, Taunine, acetaminophen-induced necrosis, thrombolytic synergr (dogs), 887 thrombolytic synergy (dogs), 887 hepatoprotective effects, cystathio- SKF 10,047, analgesic effects (monkeys), Striatum, basal ganglia neuropeptide sys- nine (rats), 667 197 Taurocholate Sleep, long- and short-, ethanol sensitivity, tems, cocaine (rats), 818 Stroke, glutamate-induced cytotoxicity, models of hepatic elimination (rats), 1048 brain tyrosine availability (mice), 556 protection with antioxidants, neu- sodium-dependent uptake, basolateral Slotkin, T. A., see Kudlacz, E. M., 236 liver plasma membrane vesicles ronal cells (mice), 1132 Smallwood, R A., see Angus, P. W., 1043 (rats), 301 Stromal cells, bone marrow, B-lympho- Smallwood, R. A., see Ching, M. S., 1048 poiesis regulation, hydroquinone Taylor, M. D., see Haleen, S. J., 22 Smith, J. M., see Post, J. M., 591 Tech, S. K., see Mendelson, J. H., 902 (mice), 582 Snell, L. D., see Ferkany, J. W., 100 Terbutaline, phosphatidic acid phospha- Submandibular gland, muscarinic receptors Snyder, A. M., see France, C. P., 197 tase, basal activity, neonatal lung in lung (humans, guinea pigs, rats), Sodium (rats), 236 309 -dependent taurocholate uptake, basolat- Tetrahydroaminoacridine, regulation, mus- Substance P cmi liver plasma membrane vesicles carinic receptor subtypes (rats), 573 activation of peritoneal mast cells (rats), (rats), 301 Thiazide, diuretic receptors, autoradi- transport in bladder membrane, phthalate 329 ographic localization, metolazone basal ganglia neuropeptide systems, co- acid esters (toads), 910 (rats), 414 Sodium channel, stimulation, PD 122860 caine (rats), 818 Thionidazine (rats), 22 Substantia nigra, basal ganglia neuropep- mesoridazine and sulforidazine Sodium-potassium, skeletal muscle pump tide systems, cocaine (rats), 818 anticholinergic properties (rabbits), 126 concentration, cardiac glycoside dis- Sufentanil, tolerance to respiratory actions antidopaminergic properties, corpus tnibution, children, 721 (rats), 371 striatum (rabbits), 117 Sodium-potassium-ATPAse, vanadate Sugihara, M., see Okabe, E., 286 Thiorphan, tachykinin-induced potentia- stimulation, N-ethylmaleimide san- Sugiyama, Y., see Nohjoh, T., 324 tion, nerve-mediated contractions, sitivity, nephron (rats), 534 Sugiyama, Y., see Suzuki, H., 979 vas deferens (rats), 678 Somatostatin, atrial and ventricular con- Sulfone, sulfide metabolites and, omepra- Thoolen, M. J. M. C., see Chiu, A. T., 867 tractile responses, differential ef- sole metabolism, liver (rats), 1043 Thrombolysis, sulotroban and streptoki- fects, heart (guinea pigs), 726 Sulforidazine nasa, synergy (dogs), 887 Sosnowski, M., Stevens, C. W and Yaksh, thioridazine and mesoridazine Thromboxane A,, functional receptors, T. L.: Assessment of the role of A1/ anticholinergic properties (rabbits), 126 HEL cells, 923 Vol. 250 1174 Index era! medullary neurons, hypotension Thurman, R. G., see Zhong, Z., 470 Thtwilem, G. F., see Tuman, R W., 836 Tibirica, E., Mermet, C., Feldman, J., Tyrosine, availability, ethanol sensitivity, correlation, clonidine (rats), 642 Vuorela, A., see M#{227}nnistO#{246},P. T., 1028 Gonon, F. and Bousquet, P.: Come- long- and short-sleep mice, 556 lation between the inhibitory effect on catecholaminergic ventrolateral Waeldele, F., see Gies, J.-P., 309 U-50,488H, tolerance development, sero- medullary neurons and hypotension Walle, T., see Pearson, A. A., 759 tonin, antinociception (mice), 508 evoked by clonidine: A voltammetric Wang, S.-X., Sutfin, T. A., B#{225}arnhielm, C. Uemura, D., see Ishihara, H., 388 approach, 642 and Reg#{224}rdh,C. G.: Contribution of Ureta, H., see Salas, S. P., 992 Timmermans, P. B. M. W. M., see Chiu, A. the intestine to the first-pass metab- Urine, composition, active furosemide frac- T., 867 olism of felodipine in the rat, 632 tion, nephrotic syndrome, 772 Timmermans, P. B. M. W. M., see Wong, Wang, X.-L., see Ravens, U., 364 Uterus, epidemmal growth factor-induced P. C., 515 Warnick, J. E., see Ohno, Y., 177 contractions, blockade, indometha- Tinel, M., Descatoire, V., Larrey, D., Los- Watabe, S., see Ishihara, H., 388 din or nordihydroguaritic acid (rats), per, J., Labbe, G., Letteron, P. and Watkins, J. B., 111: Exposure of rats to in- 882 Pessayre, D.: Effects of clarithromy- halational anesthetics alters the hep- din on cytochrome P-450. Compani- atobiliary clearance of cholephilic xc- son with other macrolides, 746 nobiotics, 421 Vagus nerve, effects ofopioid agonists, sym- To, A. C. S., see Chen, J.-C., 141 pathetic and parasympathetic trans- Watkins, R. W., see Sybertz, E. J., 624 Toda, N., see Minami, Y., 1055 Weiler, M. H.: Muscariic modulation of mission, heart (dogs), 1087 Tomasini, C., see Beani, L,, 682 Valantinas, J., see Zimmerli, B., 301 endogenous acetylcholine release in Tomera, J. F. and Martyn, J.: Intraperito- rat neostriatal slices, 617 Valet, P., see Taouis, M., 1061 Weiner, N., see French, T. A., 556 neal endotoxin but not protein mal- Valproic acid, amygdala-kindled rats, 1067 Weishaar, R. E., see 22 nutrition shifts d-tubocurarine dose- Vanadate, N-ethylmaleimide-sensitive Haleen, S. J., B.-A., 611 response curves in mouse gastrocne- adenosine triphosphatase, stimula- Weiss, H. R, see Acad, Wells, P. G., see Wong, M., 336 mius muscle, 216 tion, nephron (rats), 529 Tomes, A. M., Rodriguez, J. V. and ElIas, Vanderheyden, P., see Gies, J.-P., 309 Wettwer, E., see Ravens, U., 364 M. M.: Vulnerability of the thick as- Vas deferens, tachykinin-induced potentia- Widzowski, D. V., see Cory-Slechta, D. A., cendinglimb to glutathione depletion tion, nerve-mediated contractions, 800 Wierda, D., see King, A. G., 582 in rat kidney Effects of diuretics and thiorphan effect (rats), 678 Willets, J., see 100 indomethacin, 247 Vasoconstniction Ferkany, J. W., Touchet, N., see Trugman, J. M., 1156 adenosine-angiotensin II interactions, Williams, J. T., see Bobker, D. H., 37 Tracey, W. R., Bend, J. R., Hamilton, J. T. noradrenergic neurotransmission Wilson, D. E., see Bennett, D. A., 454 and Paterson, N. A. M.: Role of li- (rats), 433 Wojnicki, F. H., see Barrett, J. E., 788 Wong, M. and Wells, P. G.: Modulation of poxygenase, cycbooxygenase and cy- blood vessel response to norepinephrine, tochrome P-450 metaboites in con- neuropeptide Y, sympathetic field embyronic glutathione reductase and tractions of isolated guinea pig pul- stimulation (rabbits), 523 phenytoin teratogenicity by 1,3- monary venules induced by hypoxia renal, cyclosporine, mechanism (rats), bis(2-chloroethyl)-1-nitrosourea, 336 Wong, P. C., Price W. A., Reilly, T. M., and anoxia, 1097 896 Trachea, antagonism of muscarinic re- renal periarterial nerve stimulation-in- Duncia, J. V. and Timmermans P. B. M. W. M.: Antihypertensive spouses, gallamine, pirenzipine duced, low frequency, purinergic nism of captopril in renal hyperten- (rats), 944 transmitter release (rats), 764 sive rats: Studies with a nonpeptide Trachte, G. J., see Drewett, J. G., 428 Vasoconstnictors Tractus solitarius, L-glutamate as neuro- decreased renal vascular responses, rise in angiotensin II receptor antagonist and an angiotensin II monoclonal transmitter, baroreceptor informa- blood pressure, cyclosporine (mats), tion (rats), 953 1105 antibody, 515 Tnichlonmethiazide endothelin effects, regional blood flow Wong, P. C., see Chiu, A. T., 867 furosemide-induced diuresis, additive di- (monkeys), 1125 Woods, J. H., see France, C. P., 197, 937 Woods, J. H., see Koek, W., 1019 uretic effect, 5-8666 (rats), 659 Vasodilation, nonneurogenic relaxation, Wooten, G. F., see Trugman, J. M., 1156 S-8666 effect, urinary calcium excretion field stimulation, coronary artery (rats), 654 (cattle), 461 Trichothecenes, differential association of Vasodilatom Xanthine oxidase, punines and, reperfusion T-2 and T-2 tetraol, mammalian diazoxide and cromakalim, inhibition by injury, liver (rats), 470 cells, 860 glibenclamide (rabbits, rats), 261 Xanthines, adenosine receptor prodrugs, Tnimetrexate, hepatic uptake and biliary PD 122860, sodium channel stimulation, kidney-selective dialkylxanthines, 79 output, methotrexate, structural calcium channel blocking (rats), 22 Xenobiotics, cholephilic, hepatobiliary specificity (rats), 221 pulmonary response, adenosine, pulmo- clearance, inhalational anesthetics Troponin C, calcium binding, ATPase activ- nary vascular bed (cats), 170 (rats), 421 ity and MCI-l54, cardiac muscle Vaughn, D. A., see Beaumont, K., 414 (dogs), 272 Vein, adrenoceptor mechanisms (dogs), Trugman, J. M., Arnold, W. S., Touchet, N. 1119 Yaksh, T. L., see Sosnowski, M., 915 and Wooten, G. F.: D, dopamine ag- Vemulapalli, S., see Sybertz, E. J., 624 Yaksh, T. L., see Stevens, C. W., 1 onist effects assessed in vivo with Vion-Dury, J., Mason, S., Devoisselle, J. M., Yang, X.-M., Luo, Z.-P. and Zhou, J.-H.: [‘4C.2-deoxyglucose autoradiogra- Sciaky, M., Desmoulin, F., Confort- Behavioral evidence for the role of phy, 1156 Gouny, S., Coustaut, D. and Cozzone, noradrenaline in the pltative anxi- Tschirhart, E., see Mousli, M., 329 P. J.: Liposome-mediated delivery of ogenic actions of the inverse benzo- D-Tubocuranine, dose-response curves, in- gadolinium-diethylenetriaminOpen- diazepine receptor agonist methyl-4- traperitoneal endotoxin, gastrocne- taacetic acid to hepatic cells: A P-31 ethyl6,7-dimethoxy-fi-carbOlifle-3- carboxylate, 358 mius muscle (mice), 216 NMR study, 1113 Tuman, R. W., Bowden, C. R., Inman, M., Voelker, J. R., Jameson, D. M. and Brater, Yonekura, H., see Honiuchi, A, 734 Yoshioka, M.: Effect of a novel 5- Altszuler, N. and Tutwiler, G. F.: Ef- D. C.: In vitro evidence that urine hydroxytryptamine,-antagonist, fect of the fatty acid oxidation inhib- composition affects the fraction of GR38032F, on the 5-hydroxytrypt- itor methyl palmoxirate (methyl 2- active furosemide in the nephrotic amine-induced increase in carotid tetradecylglycidate) on recovery from syndrome, 772 sinus nerve activity in rats, 637 insulin-induced hypoglycemia in di- Voicer, L., see Chen, J-C., 141 Young, H. C., see Gogas, K. K, 476 abetic dogs, 836 Voltammetry, catecholaminergic ventrolat- 1989 Index 1175

Zawilska, J. and luvone, P. M.: Catechol- Zeng, Y. Y., Benishin, C. G. and Pang, P. Zhang, L, see Barrett, J. E., 788 amine receptors regulating serotonin K. T.: Guanine nucleotide binding Zhong, Z, Lemasters, J. J. and Thurman, N-acetyltransferase activity and me- proteins may modulate gating of cal- R. G.: Role of purines and xanthine latonin content ofchicken retina and cium channels in vascular smooth oxidase in reperfusion injury in per- pineal glandi D,-dopamine receptors muscle. IL Studies with guanosine 5’- fused rat liver, 470 in ret4na and alpha/-2 adrenergic re- (-y)triphosphate, 352 Zhou, J.-H., see Yang, X.-M., 358 ceptors in pineal gland, 86 Zeng, Y. Y., Benishin, C. G. and Pang, P. Ziegler, R. J., see Drewett, J. G., 428 Zaza, A., Malfatto, G. and Rosen, M. R: K. T.: Guanine nucleotide binding Zimmeni, B., Valantinas, J. and Meier, P. Electrophysiologic effects of ketan- proteins may modulate gatingof cal- J.: Multispecificity of Na-dependent senin on canine purkinje fibers, van- cium channels in vascular smooth taurocholate uptake in basolateral tricular myocardium and the intact muscle. I. Studies with fluoride, 343 (sinuosoidal) rat liver plasma mem- heart, 397 Zhang, J. F., see Steinberg, S. F., 1141 brane vesicles, 301