(12) United States Patent (10) Patent No.: US 6,190,315 B1 Kost Et Al
USOO6190315B1 (12) United States Patent (10) Patent No.: US 6,190,315 B1 KOst et al. (45) Date of Patent: Feb. 20, 2001 (54) SONOPHORETIC ENHANCED Grups & Frohmüller, “Cyclic Interferon Gamma Treatment TRANSIDERMAL TRANSPORT of Patients with Metastatic Renal Carcinoma, Br. J. Urol ogy 64(3):218–220 (1989). (75) Inventors: Joseph Kost, Omer (IL); Samir S. Junginger, et al., “Visualization of Drug Transport AcroSS Mitragotri, Cambridge; Robert S. Human Skin and the Influence of Penetration Enhancers,” in Langer, Newton, both of MA (US) Drug Permeation Enhancement (Hsieh, Ed.), pp. 59-89, Marcel Dekker, Inc.:New York, 1994. (73) Assignee: Sontra Medical, Inc., Cambridge, MA Kost & Langer, “Ultrasound-Mediated Transdermal Drug (US) Delivery” in Topical Drug Bioavailability Bioequivalence (*) Notice: Under 35 U.S.C. 154(b), the term of this and Penetration (Maibach & Shah, Eds.), pp. 91-104, patent shall be extended for 0 days. Plenum Press:New York, 1993. Krall, et al., World Book of Diabetes in Practice Elsevier: (21) Appl. No.: 09/227,623 Amsterdam, 1988. Levy, et al., “Effect of Ultrasound on Transdermal Drug (22) Filed: Jan. 8, 1999 Delivery to Rats and Guinea Pigs,” J. Clin. Invest. 83:2074–2078 (1989). Related U.S. Application Data Parkin, et al., “Atopic manifestations in the acquired (60) Provisional application No. 60/070,813, filed on Jan. 8, immune deficiency Syndrome: response to recombinant 1998. interferon gamma,” Br. Med. J. 294:1185-1186 (1987). (51) Int. Cl." - A61B 65/20 Prausnitz, et al., “Electroporation of mammalian Skin: A (52) U.S. Cl. ............................................... 600/309; 604/22 mechanism to enhance transdermal drug delivery,” Proc.
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