DOCSLIB.ORG

Handbook of Pharmaceutical Controlled Release Technology

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Handbook of Pharmaceutical Controlled Release Technology Handbook of Pharmaceutical Controlled Release Technology executive editor Donald L. Wise Cambridge Scientific, Inc. Cambridge, Massachusetts associate editors Lisa Brannon-Peppas DebraJ. Trantolo Biogel Technology, Inc. Cambridge Scientific, Inc. Indianapolis, Indiana Cambridge, Massachusetts Alexander M. Klibanov Gary E. Wnek Robert S. Langer Virginia Commonwealth University Massachusetts Institute of Technology Richmond, Virginia Cambridge, Massachusetts Michael J. Yaszemski Antonios G. Mikos Mayo Clinic Rice University Rochester, Minnesota Houston, Texas Nicholas A. Peppas Purdue University West Lafayette, Indiana MARCEL MARCEL DEKKER, INC. NEW YORK • BASEL mD E K K E R Contents Preface m Part I: Polymers as Drug Delivery Carriers 1. Hydrophilic Cellulose Derivatives as Drug Delivery Carriers: 1 Influence of Substitution Type on the Properties of Compressed Matrix Tablets Carmen Ferrero Rodriguez, Nathalie Bruneau, Jerome Barra, Dowthee Alfonso, and Eric Doelker 2. Poly(Vinyl Alcohol) as a Drug Delivery Carrier 31 Surya K. Mallapragada and Shannon McCarthy-Schroeder 3. Development of Aery late and Methacrylate Polymer Networks for 47 Controlled Release by Photopolymerization Technology Robert Scott, Jennifer H. Ward, and Nicholas A. Peppas 4. Smart Polymers for Controlled Drug Delivery 65 Joseph Kost and SmadarA. Lapidot 5. Complexing Polymers in Drug Delivery 89 Anthony M. Lowman 6. Polylactic and Polyglycolic Acids as Drug Delivery Carriers 99 Lisa Brannon-Peppas and Michel Vert 1 • Use of Infrared and Raman Spectroscopy for Characterization of 131 Controlled Release Systems A. B. Scranton, B. Drescher, E. W. Nelson, and J. L. Jacobs 8. Accurate Models in Controlled Drug Delivery Systems 155 Balaji Narasimhan Part II: Mechanism-Based Classification of Controlled Release Devices 9. Drug Release from Swelling-Controlled Systems 183 Paolo Colombo, Patrizia Sand, Ruggero Bettini, Christopher S. Brazel, and Nicholas A. Peppas vii viii Contents 10. Superporous Hydrogels as a Platform for Oral Controlled Drug Delivery 211 Jun Chen, Haesun Park, and Kinam Park 11. Osmotic Implantable Delivery Systems 225 Cynthia L. Stevenson, Felix Theeuwes, and Jeremy C. Wright 12. Bioadhesive Controlled Release Systems 255 Nicholas A. Peppas, Monica D. Little, and Yanbin Huang Part III: Micro- and Nanoparticulate Release Systems 13. Microencapsulation Technology: Interfacial Polymerization Method 271 A. Atilla Hincal and H. Siiheyla Kas 14. Nanoparticulate Controlled Release Systems for Cancer Therapy 287 C. Dubernet, E. Fattal, and P. Couvreur 15. Microencapsulation Using Coacervation/Phase Separation: An Overview 301 of the Technique and Applications H. Siiheyla Kas, and Levent Oner 16. Microsphere Preparation by Solvent Evaporation Method 329 A. Atilla Hincal and Sema 17. Nanosuspensions: A Formulation Approach for Poorly Soluble 345 and Poorly Bioavailable Drugs R. H. Mullen B. H. L. Bohm, and M. J. Grau 18. Large-Scale Production of Solid Lipid Nanoparticles (SLN) 359 and Nanosuspensions (DissoCubes) R. H. Miiller, A. Dingier, T. Schneppe, and S. Gohla 19. Solid Lipid Nanoparticles (SLN) as a Carrier System for the Controlled 377 Release of Drugs R. H. Miiller, A. Lippacher, and S. Gohla 20. Stability of Encapsulated Substances in Poly(Lactide-co-Glycolide) 393 Delivery Systems Steven P. Schwendeman, Anna Shenderova, Gaozhong Zhu, and Wenlei Jiang 21. Development of Polysaccharide Nanoparticles as Novel Drug Carrier Systems 413 C. Vauthier and P. Couvreur Part IV: Classification of Controlled Release Devices According to Administration Site 22. An Overview of Controlled Release Systems 431 S. Venkatraman, N. Davar, A. Chester, and L. Kleiner Contents ix 23. Research and Development Aspects of Oral Controlled-Release Dosage Forms 465 Yihong Qiu and Guohua Zhang 24. A Gastrointestinal Retentive Microparticulate System to Improve Oral 505 Drug Delivery Y. Kawashima, H. Takeuchi, and H. Yamamoto 25. In Vitro-In Vivo Correlations in the Development of Solid Oral Controlled 527 Release Dosage Forms Yihong Qiu, Emil E. Samara, and Guoliang Cao 26. Gamma Scintigraphy in the Analysis of the Behavior of Controlled 551 Release Systems C. G. Wilson and N. Washington 27. Electrically Assisted Transdermal Delivery of Drugs 567 Ajay K. Banga 28. A Novel Method Based on Artificial Neural Networks for Optimizing 583 Transdermal Drug Delivery Systems Kozo Takayama and Tsuneji Nagai 29. Transdermal Drug Delivery by Skin Electroporation 597 Tani Chen, Robert Longer, and James C. Weaver 30. Enhancement of Transdermal Transport Using Ultrasound in Combination 607 with Other Enhancers Samir Mitragotri, Robert Langer, and Joseph Kost 31. Electrotransport Systems for Transdermal Delivery: 617 A Practical Implementation of Iontophoresis Erik R. Scott, J. Bradley Phipps, J. Richard Gyory, and Rama V. Padmanabhan Part V: Peptide and Protein Release Systems 32. Controlled Release Protein Therapeutics: Effects of Process 661 and Formulation on Stability Paul A. Burke 33. Solid-State Chemical Stability of Peptides and Proteins: Application 693 to Controlled Release Formulations Elizabeth M. Topp, Yuan Song, Ashley Wilson, Rong Li, Michael J. Hageman, and Richard L. Schowen 34. Growth Factor Release from Biodegradable Hydrogels 725 to Induce Neovascularization Yoshito Ikada and Yasuhiko Tabata x Contents 35. Biopolymers for Release of Interleukin-2 for Treatment of Cancer 743 Debra J. Trantolo, Joseph D. Gresser, A. Ganiyu Jimoh, Donald L. Wise, and James C. Yang Part VI: Medical Applications of Drug Delivery 36. Osmotic Drug Delivery from Asymmetric Membrane Film-Coated 751 Dosage Forms Mary Tanya am Ende, Scott M. Herbig, Richard W. Korsmeyer, and Mark B. Chidlaw 37. Controlled Release Pain Management Systems 787 Vasif Hasirci, Dilek Sendil, Leonidas C. Goudas, Daniel B. Carr, and Donald L. Wise 38. Biodegradable Systems for Long-Acting Nestorone 807 Debra J. Trantolo, Donald L. Wise, A. J. Moo-Young, Yung-Yueh Hsu, and Joseph D. Gresser 39. Preparation and Evaluation of Buprenorphine Microspheres 821 for Parenteral Administration William R. Ravis, Yuh-Jing Lin, and Ram Murty 40. Prolonged Release of Hydromorphone from a Novel Poly(Lactic-co-Glycolic) 837 Acid Depot System: Initial In Vitro and In Vivo Observations Leonidas C. Goudas, Daniel B. Carr, Richard M. Kream, Louis Shuster, William M. Vaughan, Joseph D. Gresser, Donald L. Wise, and Debra J. Trantolo 41. Incorporation of an Active Agent into a Biodegradable Cement: 849 Encapsulation of the Agent as Protection from Chemical Degradation During Cure and Effect on Release Profile Joseph D. Gresser, Debra J. Trantolo, Pattisapu R. J. Gangadharam, Hisanori X. Nagaoka, Yung-Yueh Hsu, and Donald L. Wise 42. The Pharmacoeconomic Value of Controlled Release Dosage Forms 865 Laura B. Gardner Index 873.
Load more

Recommended publications
  • Curriculum Vitae Henry Brem, M.D
    Henry Brem, M.D. 1 CURRICULUM VITAE HENRY BREM, M.D. TABLE OF CONTENTS DEMOGRAPHIC INFORMATION ............................................................................................................................................ 2 RESEARCH ACTIVITIES ................................................................................................................................................................. 3 Peer-Reviewed Articles: ................................................................................................................................................................. 3 Editorials, Reviews: ...................................................................................................................................................................... 22 Book Chapters, Monographs: ....................................................................................................................................................... 22 Books: ........................................................................................................................................................................................... 25 Other media (films, videos, CD-ROMSs, slide sets): ................................................................................................................... 25 Inventions, Patents, Copyrights (pending, awarded) .................................................................................................................... 26 Extramural Sponsorships (current, pending,
    [Show full text]
  • Ben Gurion University of the Negev Biotechnology Engineering Study
    Committee for the Evaluation of Biotechnology & Biotechnology Engineering Study Programs Ben Gurion University of the Negev Biotechnology Engineering Study Program Evaluation Report December 2012 1 Contents Chapter 1: Background…………………………………………………………………..............................3 Chapter 2: Committee Procedures………...………..……………………………..…………………...4 Chapter 3: Evaluation of Biotechnology Engineering Study Program at Ben Gurion University of the Negev……………………………………………………………………5 Appendices: Appendix 1 – Letter of Appointment Appendix 2 - Schedule of the visit 2 Chapter 1: General Background At its meeting on July 25, 2010, the Council for Higher Education (CHE) decided to evaluate study programs in the field of Biotechnology and Biotechnology Engineering during the academic year 2012. Following the decision of the CHE, the Minister of Education, who serves ex officio as Chairperson of the CHE, appointed a Committee consisting of: • Prof. Moshe Rosenberg, Department of Food Science & Technology, UC Davis, USA, Committee Chair1 • Prof. Gad Galili, Department of Plant Sciences, Weizmann Institute of Science, Israel • Prof. Milica Radisic, Institute of Biomaterials and Biomedical Engineering ,Department of Chemical Engineering and Applied Chemistry, University of Toronto, Canada2 • Prof. Joseph Shiloach, Biotechnology Core Lab, NIH- National Institutes of Health, USA • Ms. Yael Elbocher - Coordinator of the Committee on behalf of the CHE. Within the framework of its activity, the Committee was requested to:3 1. Examine the self-evaluation reports, submitted by the institutions that provide study programs in Nutritional Sciences, and to conduct on-site visits at those institutions. 2. Submit to to CHE an individual report on each of the evaluated academic units and study programs, including the Committee's findings and recommendations. 3. Submit to the CHE a general report regarding the examined field of study within the Israeli system of higher education including recommendations for standards in the eval- uated field of study.
    [Show full text]
  • Microneedle Based Device to Sample Interstitial Fluid
    MICRONEEDLE BASED DEVICE TO SAMPLE INTERSTITIAL FLUID THROUGH SKIN A Dissertation Presented to The Academic Faculty by Pradnya P. Samant In Partial Fulfillment of the Requirements for the Degree Ph.D. in the School of Chemical and Biomolecular Engineering Georgia Institute of Technology May 2018 COPYRIGHT © 2018 BY PRADNYA SAMANT MICRONEEDLE BASED DEVICE TO SAMPLE INTERSTITIAL FLUID THROUGH SKIN Approved by: Dr. Mark R. Prausnitz, Advisor Dr. Hang Lu School of Chemical and Biomolecular School of Chemical and Biomolecular Engineering Engineering Georgia Institute of Technology Georgia Institute of Technology Dr. Julie Champion Dr. Paul Yager School of Chemical and Biomolecular Department of Bioengineering Engineering University of Washington Georgia Institute of Technology Dr. David Ku School of Mechanical Engineering Georgia Institute of Technology Date Approved:30 November, 2017 To my father ACKNOWLEDGEMENTS Although it is my name on the degree, it is supported by the valuable support and contributions of many others. First and foremost, I would like to thank my advisor Dr. Mark Prausnitz. Throughout the duration of my PhD he has been a solid source of strength. I have learnt from him essential skills in sound scientific practice, creative problem solving, and the importance of discipline and organization in research. His expertise in oral and written communication has sharpened my soft skills and enabled me to become a better communicator. Working with him and observing him closely over the years, I have admired his intelligence and learnt to stay grounded and humble while being successful. It is no exaggeration to say that he has made me a better scientist and an even better person.
    [Show full text]
  • Berberine Encapsulated Lecithin–Chitosan Nanoparticles As Innovative Wound Healing Agent in Type II Diabetes
    pharmaceutics Article Berberine Encapsulated Lecithin–Chitosan Nanoparticles as Innovative Wound Healing Agent in Type II Diabetes Dibya Sundar Panda 1 , Hussein M. Eid 2 , Mohammed H. Elkomy 1,* , Ahmed Khames 3 , Randa M. Hassan 4 , Fatma I. Abo El-Ela 5 and Heba A. Yassin 6 1 Department of Pharmaceutics, College of Pharmacy, Jouf University, Sakaka 72388, Saudi Arabia; [email protected] 2 Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Beni-Suef University, Beni-Suef 62511, Egypt; [email protected] 3 Department of Pharmaceutics and Industrial Pharmacy, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia; [email protected] 4 Department of Cytology and Histology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt; [email protected] 5 Department of Pharmacology, Faculty of Veterinary Medicine, Beni-Suef University, Beni-Suef 62511, Egypt; [email protected] 6 Pharmaceutics Department, Faculty of Pharmacy, AlSalam University, Tanta 31527, Egypt; [email protected] * Correspondence: [email protected]; Tel.: +966-560967705 Abstract: The aim of this research is to formulate a lecithin–chitosan based nanoparticulate sys- tem loaded with berberine (BER-LC-CTS-NPs) that could be integrated into a topically applied formulation and assessed for healing wounds in a diabetic animal model. In order to formulate BER- Citation: Panda, D.S.; Eid, H.M.; LC-CTS-NPs, soybean lecithin, isopropyl myristate, and berberine dispersed in ethanolic solution Elkomy, M.H.; Khames, A.; Hassan, were added into an aqueous solution of chitosan dropwise with sonication.
    [Show full text]
  • What's Inside
    Newsletter A publication of the Controlled Release Society Volume 30 • Number 1 • 2013 What’s Inside 40th CRS Annual Meeting & Exposition Interview with Joachim Kohn Intracellular Delivery of Bioactive Molecules Using Liposomes Surface-Modified with Cell-Penetrating Peptide Octa-arginine for Improved Anticancer Activity NanoDDS Symposium Report Preclinical Sciences & Animal Health Advances Chapter News BUSINESS OPPORTUNITIES! Discover 40th Annual Meeting & Exposition of the Controlled Release Society July 21–24, 2013 Hawaii Convention Center Honolulu, Hawaii, U.S.A. Exhibit • Connect with the worldwide delivery science community with an exhibit where 1,300+ attendees can find you. • NEW! Identify your company as a first-time exhibitor from Asia or the Pacific with a tabletop in the Asia Pacific Pavilion. Make a Presentation • Present your company’s latest products, technologies, or research with a one-hour Technology Forum. • Tell about your novel technology, especially if yours is a young company, with a five-minute Soapbox presentation. Sponsor • Stand out and be recognized with a sponsorship. Support delivery science. Advertise • Invite attendees to come to your exhibit and presentations with an ad in the Annual Meeting Program Book. • “Spotlight” your company with a feature article and ad in the CRS Newsletter. Attend the Program • Gain a competitive advantage. Increase your understanding of delivery science and your customers’ needs by attending the outstanding program. Act NOW to be included in the 2013 Program Book. Contact Debby Woodard, Director of Development +1.651.994.3817 | [email protected] www.controlledreleasesociety.org/meeting Newsletter Charles Frey Vol. 30 • No. 1 • 2013 Editor Table of Contents From the Editor .................................................................................................................
    [Show full text]
  • (12) United States Patent (10) Patent No.: US 6,190,315 B1 Kost Et Al
    USOO6190315B1 (12) United States Patent (10) Patent No.: US 6,190,315 B1 KOst et al. (45) Date of Patent: Feb. 20, 2001 (54) SONOPHORETIC ENHANCED Grups & Frohmüller, “Cyclic Interferon Gamma Treatment TRANSIDERMAL TRANSPORT of Patients with Metastatic Renal Carcinoma, Br. J. Urol ogy 64(3):218–220 (1989). (75) Inventors: Joseph Kost, Omer (IL); Samir S. Junginger, et al., “Visualization of Drug Transport AcroSS Mitragotri, Cambridge; Robert S. Human Skin and the Influence of Penetration Enhancers,” in Langer, Newton, both of MA (US) Drug Permeation Enhancement (Hsieh, Ed.), pp. 59-89, Marcel Dekker, Inc.:New York, 1994. (73) Assignee: Sontra Medical, Inc., Cambridge, MA Kost & Langer, “Ultrasound-Mediated Transdermal Drug (US) Delivery” in Topical Drug Bioavailability Bioequivalence (*) Notice: Under 35 U.S.C. 154(b), the term of this and Penetration (Maibach & Shah, Eds.), pp. 91-104, patent shall be extended for 0 days. Plenum Press:New York, 1993. Krall, et al., World Book of Diabetes in Practice Elsevier: (21) Appl. No.: 09/227,623 Amsterdam, 1988. Levy, et al., “Effect of Ultrasound on Transdermal Drug (22) Filed: Jan. 8, 1999 Delivery to Rats and Guinea Pigs,” J. Clin. Invest. 83:2074–2078 (1989). Related U.S. Application Data Parkin, et al., “Atopic manifestations in the acquired (60) Provisional application No. 60/070,813, filed on Jan. 8, immune deficiency Syndrome: response to recombinant 1998. interferon gamma,” Br. Med. J. 294:1185-1186 (1987). (51) Int. Cl." - A61B 65/20 Prausnitz, et al., “Electroporation of mammalian Skin: A (52) U.S. Cl. ............................................... 600/309; 604/22 mechanism to enhance transdermal drug delivery,” Proc.
    [Show full text]
  • Chemical Materials and Their Regulation of the Movement of Molecules
    PERSPECTIVE Chemical materials and their regulation of the movement of molecules Robert Langer MIT, Cambridge, MA, USA Quarterly Reviews of Biophysics (2015), 48(4), pages 424–428 doi:10.1017/S0033583515000165 Abstract. Materials chemistry has been fundamental to the enormous field that encompasses the delivery of molecules both to desired sites and/or at desired rates and durations. The field encompasses the delivery of molecules including fertilizers, pesticides, herbicides, food ingre- dients, fragrances and biopharmaceuticals. A personal perspective is provided on our early work in this field that has enabled the controlled release of ionic substances and macromolecules. Also discussed are new paradigms in creating biomaterials for human use, the non-invasive delivery of molecules through the skin and lungs, the development of intelligent delivery systems and extensions to nanomedicine. With the advent of potentially newer biopharmaceutics such as siRNA, mRNA and gene editing approaches and their use being limited by delivery, future research in this field may be more critical than ever before. Key words: Chemical materials molecular delivery. Materials are used to control, and in many cases, direct the de- weeks period. Using an ophthalmic microscope, we could livery of specific molecules. The applications are vast and in- measure the length of the longest vessel. However, we clude herbicides, pesticides, fertilizers, aquaculture, household needed to place the macromolecular inhibitors in the cor- products (e.g., fragrances), nutrition, and particularly drugs neas in such a way that did not cause any inflammation and biopharmaceuticals (Langer & Wise, 1984). Hundreds of (or vascularization) in the cornea and that delivered these millions people use such products every year and annual sales molecules continuously over this several month time period.
    [Show full text]
  • Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications
    Polymers 2012, 4, 997-1011; doi:10.3390/polym4020997 OPEN ACCESS polymers ISSN 2073-4360 www.mdpi.com/journal/polymers Review Hydrogels from Biopolymer Hybrid for Biomedical, Food, and Functional Food Applications Lin Shu Liu 1,*, Joseph Kost 2, Fang Yan 3 and Robert C. Spiro 4 1 Eastern Regional Research Center, U.S. Department of Agriculture, 600 East Mermaid Lane, Wyndmoor, PA 19038, USA 2 Ben-Gurion University, Beer-Sheva, 84105, Israel; E-Mail: [email protected] 3 School of Medicine, Vanderbilt University, 2215 Garland Avenue, MRB IV 1035J, Nashville, TN 37232, USA; E-Mail: [email protected] 4 RCS Consulting, 213 Central Avenue, Half Moon Bay, CA 94019, USA; E-Mail: [email protected] * Author to whom correspondence should be addressed; E-Mail: [email protected]; Tel.: +1-215-233-6486; Fax: +1-215-233-6795. Received: 1 March 2012; in revised form: 27 March 2012 / Accepted: 29 March 2012 / Published: 13 April 2012 Abstract: Hybrid hydrogels from biopolymers have been applied for various indications across a wide range of biomedical, pharmaceutical, and functional food industries. In particular, hybrid hydrogels synthesized from two biopolymers have attracted increasing attention. The inclusion of a second biopolymer strengthens the stability of resultant hydrogels and enriches its functionalities by bringing in new functional groups or optimizing the micro-environmental conditions for certain biological and biochemical processes. This article presents approaches that have been used by our groups to synthesize biopolymer hybrid hydrogels for effective uses for immunotherapy, tissue regeneration, food and functional food applications. The research has achieved some challenging results, such as stabilizing physical structure, increasing mucoadhesiveness, and the creation of an artificial extracellular matrix to aid in guiding tissue differentiation.
    [Show full text]
  • Moshal Scholarship Students Say “Todah”
    NEWSLETTER OF BEN-GURION UNIVERSITY OF THE NEGEV אוניברסיטת בן-גוריון בנגב Illinois Governor Signs Collaborative Magnanimous Bequest from Agreement on Behalf of University of Illinois Eric Ross to Benefit Students American Associates, Ben-Gurion University Guzik Family Antiquities of the Negev (AABGU) recently received Pathway Highlights a $17.4 million bequest on behalf of Negev History Ben-Gurion University from the estate of businessman and philanthropist Eric Ross of Photo: Carl Cox South Orange, New Jersey and West Palm Beach, Florida. In recent years, Ross and his late wife Lore BG Racing Team Puts made frequent gifts to BGU. They supported Guzik Family Antiquities Pathway Students on the Fast numerous University programs, including Highlights Negev History Track scholarships for students in need, capital projects, as well as community service programs for disadvantaged residents of the Negev region. An outgrowth of their extraordinary personal relationship with Local Hero Given Full University President Prof. Rivka Carmi, they Scholarship to BGU also made numerous contributions to the President’s Discretionary Fund. Ross rose from humble beginnings, fleeing Nazi Germany in 1938 with only $10 in his pocket and arriving in New York on what is * now infamously known as Kristallnacht. He Eric Ross receives an honorary doctoral degree started what became an extremely successful business, manufacturing plastics and vinyl went to college and was forced out of school products for the flooring industry, as well as in 1933 at the age of 14, and have now compounds for the medical industry. Ross received the University’s highest honor, I have later sold it and began his second career not yet digested it.” as a philanthropist.
    [Show full text]
  • Journal of Controlled Release 285 (2018) 252–257
    Journal of Controlled Release 285 (2018) 252–257 Contents lists available at ScienceDirect Journal of Controlled Release journal homepage: www.elsevier.com/locate/jconrel B'reshith T ⁎ Ronald A. Siegela, , Larry Brownb, Elazer R. Edelmanc,d, Robert J. Linhardte a Departments of Pharmaceutics and Biomedical Engineering, University of Minnesota, Minneapolis, MN, United States b Noveome Biotherapeutics, Inc., Pittsburgh, PA, United States c Institute for Medical Engineering and Science, MIT, Cambridge, MA, United States d Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, United States e Department of Chemistry and Chemical Biology, Department of Biology, Department of Chemical and Biological Engineering, Department of Biomedical Engineering, Rensselaer Polytechnic Institute, Troy, NY, United States ARTICLE INFO ABSTRACT means “in the beginning”. It is the first word and title of the Book of ( תיִׁשאֵרְּב ) ”Keywords: The Hebrew word “b'reshith Early days Genesis, and it describes a process of creation. The four authors were present at the beginning of Langer labs, and Langer labs the purpose of this essay is to convey the scientific and technological zeitgeist that existed in the late 1970s and early 1980s, when Bob Langer began his exceptionally creative work. While Langer labs has branched into many other areas, Bob's unique ability to recognize important problems and entice people to look beyond their own disciplines to solve them was evident from the start. We focus on the two areas of most interest to Bob at the time, namely controlled release of macromolecules from polymers, and removal of heparin in order to prevent uncontrolled bleeding during surgery.
    [Show full text]
  • הנדסה ביורפואית – סמינר מחלקתי 14:00 יום רביעי בשעה 28.12.2011 חדר בנין
    אוניברסיטת בן - גוריון בנגב BEN-GURION UNIVERSITY OF THE NEGEV ת.ד. 653, באר שבע P.O.Box 653, BEER-SHEVA 84105, ISRAEL 84105 המחלקה להנדסה ביורפואית Department of Biomedical Engineering הפקולטה למדעי ההנדסה Faculty of Engineering Science Tel. 972-8-6479614 Fax. 972-8-6479628 סמינר מחלקתי – הנדסה ביורפואית 28.12.2011 יום רביעי בשעה 14:00 בנין 51 חדר 015 (אודיטוריום בניין הננו) NANO-BASED TARGETED THERAPIES Prof. Joseph Kost Department of Chemical Engineering, Ben-Gurion University of the Negev Nanotechnology has the potential to revolutionize cancer and other therapies. Advances in protein engineering and materials science have contributed to novel nanoscale targeting approaches that may bring new hope to patients. Several nanocarriers have been approved for clinical use. However, to date, there are only a few clinically approved nanocarriers with drugs to selectively bind and target cancer cells. Nanoparticles used as drug delivery carriers consist of different biodegradable materials such as natural or synthetic polymers, lipids, or metals. Nanoparticles are taken up by cells more efficiently than larger micromolecules and therefore, could be used as effective delivery systems. For therapeutic applications, drugs can either be integrated in the matrix of the particle or attached to the particle surface. In the presentation the drug delivery aspects of nanomedicine, the molecular mechanisms underlying the interactions of nanoparticles with cell-surface receptors, biological responses and ultrasound as a targeting tool and its effect on cellular transport would be discussed. About the Lecturer Dr. Kost received his BSc and MSc degrees in Chemical Engineering, PhD at the Department of Biomedical Engineering, all from the Technion and MBA from BGU.
    [Show full text]
  • Bio-Inspired Nano-Carriers for Sub-Cellular Targeted Therapeutics
    Focal Technology Area 1: Nano-Biomedical Research Bio-Inspired Nano-Carriers for Sub-Cellular Targeted Therapeutics Research Leader Research Prof. Joseph Kost Our research in the nono-biomedical Focal Technology Area (FTA) Department of Chemical develops bio-inspired nano-carriers (NCs) aimed at sub-cellular Engineering; Dean of The Faculty targeting of therapeutics for the treatment of cancer and metabolic of Engineering Sciences diseases. Uniquely, this program’s focus on drug delivery systems and includes aspects such as: design of new nano-carriers, synthesis and characterization, intra-cellular trafficking, sub-cellular recognition, and localized cargo discharge, up to the level of in-vivo proof of efficacy. The benefits of our NCs will be dramatic for both doctors and patients, providing lower drug toxicity, more specific targeting and possibly reduced treatment costs. Getting the active compound to where it is needed and effectively delivering it, is one of the holy grails in the treatment of diseases ranging from inflammation to cancer. Our NC encapsulated therapeutics provide both patient and payer value by: • Using approved drugs and finding better ways of delivering them to their targets. • Using bioinspired compounds for drug delivery that may extend the product and patent lifecycles of drugs, via reformulation of existing compounds. • Developing new drugs and drug combinations that can be delivered together to increase the efficacy and potency for unmet medical indications. Applications & Products Our 5 year FTA has focused on the following: • Two RNAi nanoparticle drugs; targeting breast and ovarian cancer in NCs. • Peptidic NC delivery of Lonidamine to mitochondria. • NC-mediated inner membrane delivery of Phosphoinositides to modulate autophagy (a metabolic disease).
    [Show full text]