International Union of Toxicology

PROPOSAL TO THE NOMINATING COMMITTEE: MEMBERS SUITABLE FOR NOMINATION TO THE IUTOX EXECUTIVE COMMITTEE FOR THE PERIOD 2019-2022

Proposal due to Barbara Hales at the IUTOX Secretariat by: November 19, 2018 Please include a short CV for the nominee

PROPOSAL SUBMITTED BY

Member Society: Malaysian Society of Toxicology

Name and signature of IUTOX Member Society representative submitting nomination: Chan Kok Meng

Position: President

Signature:

Date: 15 November 2018

BIOGRAPHICAL DETAILS OF PROPOSED CANDIDATE

Name and signature of proposed candidate: Salmaan Hussan Inayat-Hussain

Nomination for officer or director may be indicated: Director

Date of Birth: September 5, 1968

Current Position: Head & Group Technical Authority Product Stewardship and Toxicology, Group Health, Safety, Security & Environment PETROLIAM NASIONAL BERHAD (PETRONAS)

Address: 8, Lorong Setiapuspa 2, Medan Damansara, 50490 ,

Page 1 of PROPOSAL TO THE NOMINATING COMMITTEE: MEMBERS SUITABLE FOR NOMINATION TO THE IUTOX EXECUTIVE COMMITTEE FOR THE PERIOD 2019-2022

Nationality: Malaysian

Scientific Field: Toxicology

Education: BSc (Hons)-Pharmacology (Universiti Kebangsaan Malaysia) in 1991 PhD- Toxicology (University of Leicester) in 1997

Professional positions held (with dates): Head, Global Toxicology, Group Health, Safety & Executive, PETROLIAM NASIONAL BERHAD (PETRONAS) (Feb 2013-present) Visiting Professor of Toxicology, Faculty of Engineering, Kyoto University, Japan (Oct 2012-Jan 2013) Dean & Professor of Toxicology, Faculty of Health Sciences, UKM (December 2009- October 2012) Deputy Dean, Postgraduate, Research, Industrial and International Relations, Faculty of Health Sciences, UKM (July 2008- December 2009) Professor of Toxicology, Environmental Health Programme, Faculty of Health Sciences, UKM (Apr 2008- July 2014) Visiting Research Associate, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO (Apr 1999-Mar 2000 & Apr-Dec 2004) Director, Melaka Biotechnology Corporation (July 2006- July 2007)

IUTOX positions held (with dates): Director, International Union of Toxicology Executive Committee (2016-2019) Advisor, International Union of Toxicology Education Committee (2013-2016

Member Society positions held (with dates): Full Member, Society of Toxicology (USA) - 2004-present Founding President & Executive Committee Member of Malaysian Society of Toxicology (2011-present)

Professional memberships and/or awards: UK Institute of Biology Registered Toxicologist (2005-present) Diplomate of the American Board of Toxicology (2009-present) Eurotox Registered Toxicologist (2005-present) Fellow of the Academy of Science Malaysia (awarded in 2012) Temporary Advisor, WHO Chemical Risk Assessment (2008-2010) Joint FAO/WHO Meeting on Pesticide Residues (JMPR) Roster of Toxicological and Epidemiological Experts (2010-present) Chair, IPIECA (Fuels and Products) GHS Task Force Toxicology Advisor and Professional Committee, Department of Occupational Safety and Health, Ministry of Human Resources, Malaysia (2013-present) Associate Editor, Food and Chemical Toxicology (2010-present) Steering Commitee, JSPS-Asian Core Program on Risk Based Assessment of Asian Oriented Integrated Watershed Management (2011-2016)

Page 2 of PROPOSAL TO THE NOMINATING COMMITTEE: MEMBERS SUITABLE FOR NOMINATION TO THE IUTOX EXECUTIVE COMMITTEE FOR THE PERIOD 2019-2022 Salmaan H Inayat-Hussain PhD, DABT, ERT, FASc

Head & Group Technical Authority Product Stewardship and Toxicology, Group Health, Safety, Security & Environment PETROLIAM NASIONAL BERHAD (PETRONAS)

Dr. Salmaan Inayat-Hussain joined PETRONAS in February 2013 as the Chief Toxicologist where he pioneered the area of toxicology in PETRONAS. In 2014, Salmaan played a significant role in the strategic planning of the Global Toxicology Department within the Group Health, Safety & Environment Division that was established in July 2014 and he remains committed to steering this department as the current Head. The Global Toxicology Department encompasses Product Stewardship, Ecotoxicology and Environmental Health. In 2015, Salmaan was appointed as the Group Technical Authority to provide technical leadership and drive best practices implementation in Toxicology PETRONAS-wide. Prior to joining PETRONAS, Salmaan was a Professor of Toxicology and Dean of the Faculty of Health Sciences, Universiti Kebangsaan Malaysia (UKM). He was also a Visiting Professor at Graduate School of Engineering, Kyoto University. He holds a PhD in Toxicology from the MRC Toxicology Unit, University of Leicester, England. Salmaan is the first and currently the only resident Malaysian who is an American Board Certified Toxicologist. He is also a Eurotox Registered Toxicologist. Salmaan is a Fellow of the Academy of Sciences, Malaysia. He has more than 25 years of research, teaching, consulting and industrial experience with various organizations including Yale University, University of Colorado Health Sciences Center, Karolinska Institutet, University of Osaka, King’s College London, Kyoto University, PETRONAS, Talisman, Newfields, Pfizer and Melaka Biotechnology Corporation. He was recently a Fulbright Visiting Scholar at Yale School of Public Health. In recognition of his vast expertise and contribution to toxicology, Salmaan has represented Malaysia as the Advisor to the World Health Organization (WHO) on the Development of Chemical Risk Assessment Toolkit, Risk Assessment trainer for APEC Chemical Regulators and he is the only Malaysian who is an Expert Panel member of the Joint FAO/WHO Meeting on Pesticide Residues. Furthermore, Salmaan is the current Chair for the IPIECA GHS Task Force and Director of the International Union of Toxicology (IUTOX) Executive Committee. He is the Associate Editor for Food & Chemical Toxicology journal and Editorial Board Member of several journals including Human and Experimental Toxicology, Toxicology Mechanisms and Methods and Genes and Environment. Nationally, Salmaan is the Founding President of the Malaysian Society of Toxicology. He was an Advisor to the Department of Occupational Safety and Health, Malaysia and a past member of the National Professors’ Council. He has conducted pro-bono consulting and training for Department of Environment, Environment Institute of Malaysia (EiMAS), Ministry of Health and the Department of Occupational Safety & Health.

Open PERSONAL INFORMATION

Name: Salmaan Hussain Inayat-Hussain Date and Place of Birth: September 5, 1968; Kuala Terengganu, Malaysia Citizenship: Malaysia Marital Status: Married 1992, two children (18 and 16 years old) Home Address: 8, Lorong Setiapuspa 2, Medan Damansara, 50490 Kuala Lumpur, Malaysia Office Address: Product Stewardship and Toxicology, Group HSSE, Level 63, Tower 2, PETRONAS Twin Towers, KLCC, 50088 Kuala Lumpur, Malaysia Email: [email protected] Mobile: +6012-2981689

EDUCATION

BSc (Hons) Pharmacology Universiti Kebangsaan Malaysia 1991 PhD Toxicology University of Leicester, UK 1997

PROFESSIONAL CERTIFICATION

2005-present UK Institute of Biology Registered Toxicologist 2005-present Eurotox Registered Toxicologist 2009-present Diplomate of the American Board of Toxicology

PROFESSIONAL AFFILIATION

Full Member, Society of Toxicology (USA) 2004-present Founding President & Executive Committee Member of Malaysian Society of Toxicology 2011-present Member, Expert Panel Joint FAO/WHO Meeting on Pesticide Residue 2011-present Steering Committee, JSPS-Asian Core Program on Risk Based Assessment of Asian Oriented Integrated Watershed Management 2011-2016 Fellow, Academy of Sciences Malaysia 2012-present Advisor, International Union of Toxicology Education Committee 2013-2016 Advisor, Malaysian National Professors’ Council, Natural Resources & Environment Cluster 2014-present Chair, IPIECA Globally Harmonised System Task Force 2014-present Director, International Union of Toxicology Executive Committee 2016-2019

EDITORIAL BOARD

Food and Chemical Toxicology (Associate Editor, 2011-present) Chemico-Biological Interactions (since 2001-2011) Journal of Toxicological Sciences (since 2002-present)

Open Human and Experimental Toxicology (since 2005-present) Toxicology Mechanisms and Methods (since 2015-present) Genes and Environment (since 2015-present)

PROFESSIONAL EXPERIENCE

2014-2017 Head, Global Toxicology Group Health, Safety and Environment, Petroliam Nasional Berhad (PETRONAS), Kuala Lumpur, Malaysia

As a Group Technical Authority and Head of Department, I lead a team of highly skilled professionals in the area of (eco) toxicology, product stewardship and environmental health in providing expert support to all of PETRONAS business globally as well as to provide functional advisory role to the different national and global business segments. In this role, I provide leadership and strategic direction to PETRONAS businesses and expert toxicology advice to drive an integrated approach in managing risks in PETRONAS operations globally. *Awarded the Fulbright Malaysian Professional Exchange Program to conduct a project at Yale University (School of Public Health) from August 2017 to February 2018. This project aimed to systematically assess and prioritize chemicals used in petrochemical industries specifically with regards to reproductive health hazards. This project will serve as an industrial guidance for the determination of safer alternatives as part of sustainable chemical stewardship.

2013-2014 Chief Toxicologist Group Health, Safety and Environment, Petroliam Nasional Berhad (PETRONAS), Kuala Lumpur, Malaysia

First Toxicologist in PETRONAS with responsibility to strategise and drive the development of Toxicology as a discipline and competent working team that will enhance and sustain capabilities in achieving high performance delivery. The toxicology department was officially established in July 2014.

2012-2013 Visiting Professor Research Center for Environmental Quality Management, Graduate School of Engineering, Kyoto University, Kyoto, Japan

Responsible for research on risk assessment of environmental samples including dioxins and molecular mechanisms of benzene induced apoptosis.

2010-2012 Dean Faculty of Health Sciences, Universiti Kebangsaan Malaysia

Responsible for providing a strategic direction on the faculty’s research and academic programs. Managed 170 academic staff and 130 non-academic staff.

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2008 -2009 Deputy Dean, Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia

Responsible for research, postgraduate, industrial relations and internationalization. There were 167 academic staff and 150 postgraduate students which were directly under this portfolio .

2008-2014 Professor of Toxicology Faculty of Allied Health Sciences, Universiti Kebangsaan Malaysia

Responsible for establishing an in vitro Mutagenicity Laboratory for the State of , Malaysia according to OECD GLP with a budget of MYR4.2 million (approx: USD 1.2 million). OECD GLP was granted in 2011 by Standards Malaysia. Involved in setting the direction for Toxicology curriculum development for the Bachelors and Masters Course. Subjects taught included Basic Toxicology, Environmental Toxicology, Occupational Toxicology and Health Risk Assessment

2006-2007 Chief Executive Officer Malacca Biotechnology Corporation

Responsible for 24 administration staff and 10 researchers with an operating budget of MYR 3.0 million (approx: USD 0.83 million) and research budget of MYR 1.0 million (approx: USD 0.27milion ).

2005-2012 Senior Fellow (honorary appointment) UKM Medical Molecular Biology Institute (UMBI) Hospital Universiti Kebangsaan Malaysia

Responsible in designing and execution of experiments to understand the basic mechanism of action of the toxic chemicals including quinones and styryllactones.

2004 Visiting Research Associate Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO, USA

Responsible to manage and provide direction for internal research relating to the mechanisms of cell death induced by quinones. In this role, I was responsible to supervise 2 post-doctoral fellows and provide research direction for future research in this field.

Host: Prof Dr. David Ross

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2003-2006 Associate Professor of Toxicology Environmental Health Program Faculty of Allied Health Sciences Universiti Kebangsaan Malaysia

Responsible for 7 research staff with a research budget of MYR1.0 million (approx: USD 0.27milion).

2002-2004 Program Head Environmental Health Program Faculty of Allied Health Sciences Universiti Kebangsaan Malaysia

Founding Head and managed the program which consisted of 5 faculty members and 5 non-academic staff. Taught Environmental Health and Occupational Toxicology related subjects.

1997-2002 Lecturer (Pharmacology & Toxicology) Dept of Biomedical Sciences Faculty of Allied Health Sciences Universiti Kebangsaan Malaysia

Taught Basic Pharmacology, Basic Toxicology and Occupational and Environmental Toxicology course to Doctor of Medicine, Bachelors of Biomedical Science, Bachelors of Pharmacy, Bachelors of Optometry programs.

1999-2000 Visiting Research Associate Molecular Toxicology and Environmental Health Sciences Program, School of Pharmacy, University of Colorado Health Sciences Center, Denver, CO, USA

Responsible to design and execute experiments to understand the mechanisms of benzene and the anti-psychotic remoxipride toxicity. In this role, I was responsible to conduct experiments and provide future direction for future research in this field.

Supervisor: Prof Dr. David Ross

1993-1997 Tutor Dept of Biomedical Science Faculty of Allied Health Sciences Universiti Kebangsaan Malaysia

Open On study leave, MRC Toxicology Unit, Leicester, UK

1991-1992 Hospital Service Representative Pfizer Pharmaceuticals (Malaysia) Pte. Ltd

Responsible for the marketing, disseminating current updates and conducting educational sessions for anti-hypertensives, anti-fungals and anti-microbial agents. I was also responsible for new product launching and to liaise with physicians conducting clinical trials for Pfizer products.

SELECTED OIL & GAS EXPERIENCE

1. Headed the Health and Safety consultancy section of the “Detailed Environmental Impact Assessment (EIA) study (1997-1998) Study on the olefin and derivatives plants at Kerteh, Terengganu” from 1997-1998. This project was a joint-venture project between PETRONAS and Union Carbide Corporations (USA). The EIA report was presented to the Department of Environment and approved in 1999. The plant is currently operating in Kerteh, Malaysia.

2. Trainer for Petrochemical Industries (2003-present) Conducted training on Chemical Hazard Communication and Toxicology to PETRONAS Gas Sdn Bhd staff at all levels. The training covered MSDS, hazard communication, fundamentals of toxicology, biomonitoring of chemicals including, benzene, toluene, xylene, hydrogen sulfide and others. 2003-2010

Conducted regular training to staff on behalf of TALISMAN in mercury management policy. The training covers safety awareness, understanding the health hazards of mercury, biological monitoring, occupational safety levels and biological exposure index . 2008-2013

Regular trainer for PETRONAS technical professionals and professionals from chemical industries in the areas of Environmental Health, Toxicology and Product Stewardship. 2013-present

3. Consultant, Toxicological Risk Assessment of Mercury in Petrochemical Exposed Workers (Talisman Malaysia Ltd) September 2010- March 2011 This was a consultancy project where data from the medical surveillance and biomonitoring were analyzed and a risk assessment was carried out on the workers. The findings from this study were instrumental in the establishment of the mercury biomonitoring guideline by Department of Occupational Safety and Health.

4. Engen Petroleum Limited, Cape Town, South Africa. November-December 2010 Used SAP Product Safety and Dangerous Goods for the production of GHS compliant material safety data sheet for benzene, MTBE, asbestos waste and waste containing mercury. Prepared material safety data sheets on benzene, MTBE, asbestos waste and waste containing mercury.

Open 5. Petronas Aromatics Sdn Bhd and Petronas Penapisan Terengganu Sdn Bhd, Kerteh, Terengganu. April-2011- July, 2012 Headed a collaborative study on the assessment of occupationally exposed workers to benzene and the relationship between biomarkers of exposure and genotoxic effects. 38 workers during turnaround activity were recruited for the study and blood disorder, DNA damage and urinary biomarker were determined for chronic toxicity.

6. Technical Committee Member for National Mercury Management Guidelines for Oil & Gas Industry. Feb 2011-Nov 2011 Provided toxicological input, which was critical for the Department of Occupational Safety and Health to revise the biomonitoring guideline for mercury exposure among petrochemical workers. The guideline was published in November 2011.

7. Litigation Expert Witness for petroleum product used by Continental Sime Tyre PJ Sdn Bhd. June –September, 2011 In this role, I conducted a toxicological evaluation whether Naphtha induced oral squamous cell carcinoma. I was also an expert witness and presented evidence for the defendant (Continental Sime) at the . (The court dismissed the plaintiff’s case on 21 Mar 2012)

8. Project Rainbow: HSE Due Diligence for Phu My Plastics & Chemicals Co.,Ltd, Vietnam (PMPC) May –June 2013 Conducted walkabout at PMPC and assessed chemical inventory and identified issues on health hazard and exposure. The toxicological concern was identified and reported to PETRONAS Chemicals Group.

9. PETRONAS Technical Standards and Guidelines August 2013- present Established a PETRONAS Technical Standard (PTS) on Classification of Chemicals Hazardous to Health. This PTS provides a guideline for classification of human health hazards with an emphasis on the identification of highly hazardous chemicals.

Led the establishment of several other standards and guidelines including in Management of Reproductive Toxicants, Product Stewardship, SDS Management, Management of Contract Research Organisation and Management of Third Party Laboratory Data.

10. Product Toxicity Testing 2013- present Coordinated and provided expert judgement on toxicity testing of chemical products from PETRONAS Chemicals Group and chemicals used in Enhanced Oil Recovery from PETRONAS Research. Coordinated risk based assessment of produced water and food contact material toxicity testing .

11. Process Safety- Lethal Service Requirement 2015-present Provided the methodology for screening process chemicals for lethal service based on Health Hazard Categories under GHS classification. This step wise classification was implemented for Gas Development Projects.

12. Product Risk Assessment 2014-present

Open Provided guidance on how product risk assessment is conducted for PETRONAS chemicals and mentored capability for Product Stewards. This work has resulted in the generation of the first Global Product Safety Summary for PETRONAS.

13. Assurance and Compliance 2013-present Team Leader for Tier 3 HSE assurance audit at PETRONAS Carigali Turkmenistan Sdn Bhd.

Chemical Management/ Product Stewardship auditor for Tier 3 HSE assurance for MISC and PETRONAS Fertiliser plant.

Auditor for Responsible Care Product Stewardship for Chemical Industries Council of Malaysia. Audited 2 chemical companies in 2013 and 2 chemical companies in 2014.

14. Process Owner for SAP EHS 2013-present Led the blueprint and implementation of SAP EHS modules on Product Safety, Global Label Management and Waste Card. Established a one stop portal for SDS for PETRONAS.

OTHER PROFESSIONAL TRAINING & EXPERIENCE

1. Visiting Scientist, Biochemical Toxicology Division, MRC Toxicology Unit, Leicester, United Kingdom (Supervisors: Prof G. M Cohen and Dr. Kelvin Cain) 1999

2. Visiting Scientist, Department of Biochemistry, University of Osaka, Osaka, Japan (Supervisor: Prof Naoyuki Taniguchi) 2000

3. UNESCO Research Fellow, Division of Toxicology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden (Supervisor: Prof. Sten Orennius) 2002

4. Honorary Research Fellow, Department of Molecular Medicine, King’s College, London, United Kingdom (Host: Prof. Farzin Farzaneh) 2002

5. Visiting Scientist, Department of Biomaterials and Biomimetics, Guy’s, King’s and St Thomas’ Dental Institute, University of London, UK (Host: Dr. Lucy Di Silvio) 2004

6. Visiting Scientist, Department of Global Engineering, Kyoto University, Kyoto, Japan (Host: Prof S Morisawa) 2005 & 2008

7. Visiting Scientist, Research Institute of Bioresources, Okayama University, Okayama, Japan (Host: Prof I Aoyama) 2005

8. Visiting Scientist, Department of Haematological and Molecular Medicine, King’s College, London, UK (Host: Prof Dr. Farzin Farzaneh) 2006

9. Visiting Scientist, School of Life Sciences, Keele University, Keele, UK (Host: Prof. Dr. Gwyn T Williams) 2006, 2008 & 2009

Open 10. Visiting Scientist, Department of Haematological and Molecular Medicine, King’s College, London, UK (Host: Prof Dr. Farzin Farzaneh) 2008

11. Visiting Professor, Faculty of Biosciences and Bioengineering, Universiti Teknologi Malaysia (2011)

12. Fulbright Visiting Scholar, Department of Environmental Health Sciences, Yale School of Public Health (2017-2018)

HONORS & AWARDS

1. First prize for the best oral presentation at the British Toxicology Society Spring Meeting, York (1996)

2. Recipient of the Biochemical Society Travel Grant to attend the International Union of Biochemistry and Molecular Biology (IUBMB) meeting in Edinburgh, 1996

3. Recipient of the Wellcome Trust Research Travel Grant, January-February, 1999, MRC Toxicology, Leicester, UK.

4. Visiting Research Associate Award from the University of Colorado Health Sciences Center, Denver, CO (1st April, 1999- 31st March, 2000, 1 April -31 Dec, 2004)

5. Recipient of the Young Scientist Travel Fellowships Award by IUBMB to participate in the Young Scientist Travel Fellowships Symposium and 18th International Congress of Biochemistry and Molecular Biology, 13-20 July, 2000 Birmingham, UK

6. Recipient of the ‘International Fellowship of the Dan Charitable Trust Fund for Research in the Biological Sciences’, Osaka, Japan (September-October, 2000)

7. Recipient of the International Union of Toxicology Junior Fellowship to attend the ICT-IX, Brisbane, Australia (8-13 July, 2001)

8. Honorary Research Fellow & Recipient of the Wellcome Trust Research Travel Grant, Department of Molecular Medicine, Kings’ College, London (1-10 September, 2002).

9. Recipient of “Short-term UNESCO Fellowship”, 11-31 May, 2002 at Karolinska Institutet, Stockholm, Sweden

10. Recipient of 26th International Molecular Biology Network-AMBO Fellowship 10-21 March, 2003, Research Institute of Microbial Diseases, Osaka University, Osaka, Japan

11. Awarded 2004 Society of Toxicology/International Union of Toxicology AstraZeneca Fellowship, 21 March, 2004, Baltimore, Maryland, USA

12. Recipient of the Royal Society Short-Term Fellowship, 3-14 October, 2004, Guy’s, King’s and St Thomas’ Medical and Dental Institute, Dept. Biomaterials, King’s College, London, UK.

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13. Visiting Scientist under the Japanese Society for Promotion of Science JSPS-VCC Visiting Scientist Fellowship to Kyoto University and Okayama University, Japan from 26 Jan- 10 Feb 2005, 15-24 Nov 2006 & 20-29 Nov 2008

14. Fellowship Travel Award Winner, Water Security: Integrating Lessons Learned for Water Quality, Quantity and Sustainability, International Union of Toxicology and the Brazilian Society of Toxicology, 4-6 November 2015, Natal, Brazil

15. Fulbright Malaysian Professional Exchange Program 2017-2018. Yale University School of Public Health. August 2017-February 2018

INVITED TALK & ATTENDANCE IN CONFERENCES/SEMINARS/WORKSHOPS/SYMPOSIUMS (2009- present)

1. Invited Speaker, Asian Society of Toxicology Conference, Pattaya, Thailand 18-21 June, 2018

2. Chair, Product Stewardship and Regulatory Toxicology in The Oil And Gas Industry Workshop. Congress of Toxicology for Developing Countries, Belgrade, Serbia 20 April, 2018

3. Invited Speaker, Continuing Education Course on Water Security: Integrating Lessons Learned for Water Quality and Sustainability. Congress of Toxicology for Developing Countries, Belgrade, Serbia 18 April, 2018

4. Invited Panelist, Toxicology for Health in the United Nations Sustainable Development Goals, Congress of Toxicology for Developing Countries, Belgrade, Serbia 19 April, 2018

5. Invited Speaker, Toxicological Risk Assessment & Product Safety Forum, 15 February, 2017

6. Invited Speaker, Society of Occupational and Environmental Medicine & Malaysian Medical Association, Miri, , 21 January, 2017

7. Invited Speaker, WHO Workshop on Human Biomonitoring to Support Chemical Risk Assessment, Chulabhorn Research Institute, Bangkok, Thailand 17-19 November, 2016

8. Invited Speaker, Emerging Environment and Health Linkages in Asia (Joint UNEP/WHO), The 8th Princess Chulabhorn International Science Congress, Bangkok, Thailand 16 November, 2016

9. Invited Speaker, Seminar on Mercury Control and Management in Malaysia, Department of Environment and Environmental Resources Management (ERM), Shah Alam, Selangor 12 October, 2016

10. Invited Speaker, CE Course on Water Security: Integrating Lessons Learned for Water Quality and Sustainability, ICT-XIV Congress and the X Mexican Congress of Toxicology, Merida, Mexico 2 October, 2016

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11. Invited Speaker, CPD Series 1: Medical Surveillance, Society of Occupational and Environmental Medicine-Malaysian Medical Association, Grand Seasons Hotel, Kuala Lumpur, Malaysia 3 September 2016

12. Invited Trainer, Chemical Management Course, for Malaysian Dept of Environment and Singapore National Environment Agency officers at Environment Institute of Malaysia, Department of Environment, Kuala Lumpur, Malaysia 16 August, 2016

13. Invited Speaker, Environmental Quality Council, Department of Environment, Ministry of Natural Resources and Environment, Kuala Lumpur, Malaysia 28 July, 2016

14. Invited Speaker & Toxicology Workshop Leader, PetroEnvironment 2016 Symposium, Dhahran, Saudi Arabia 22-24 February, 2016

15. Invited Speaker, Meeting of the WHO Chemical Risk Assessment Sub-Network of Developing Countries, Chulabhorn Research Institute (CRI), Bangkok, Thailand 2-4 December 2015

16. Invited Speaker, Malaysian Congress of Toxicology, Kuala Lumpur, 29- 30 October, 2015

17. Invited Speaker, Seminar on the Guideline for Sand Disposal & Environmental Regulations. Dept of Environment, Kuala Lumpur, 2 March, 2015

18. Invited Speaker, Oil Spill Health & Ecotoxicological Effects and Risk Assessment Worskhop, Kuala Lumpur, 10-11 November, 2014

19. Invited Trainer, CICM Global Product Strategy Risk Assessment, Hilton Petaling Jaya. 26 September, 2014

20. Invited Speaker, Career bridge between academia and industry. UKM Molecular Medicine Institute, 3 June, 2014

21. Invited Speaker, High CO 2 and H 2S gas fields development. Society of Petroleum Engineers Forum Series Asia Pacific, 18-23 May, 2014 Bali, Indonesia

22. Trainer, Human Health Risk Assessment for Ministry of Health Occupational and Environmental Health Doctors. KL Convention Centre 24 February, 2014

23. Invited Speaker, 13 th Asia Pacific Responsible Care Conference and Process Safety Workshop 2013, Centra Grand Mirage Beach Resort Pattaya, Thailand 8-11 October, 2013

24. Invited Lecture, The International Symposium of Health Sciences (i-Sihat 2013), Bangi, 20 August 2013

25. Invited Speaker, International Congress of Toxicology (ICTXIII), Seoul, Korea. 30 June- 3 July, 2013

Open 26. Invited Speaker, APEC/CTI/Chemical Dialogue/Regulators Forum. Regulatory Cooperation– Introductory level training on risk assessment and risk management. Bangkok, Thailand, 7-8 November, 2012

27. Advisor, The First Malaysian Congress of Toxicology: From mechanisms of toxicity to risk assessment. Kuala Lumpur, 2-3 October 2012

28. Invited Professional Development Course Trainer, Interfacing Toxicologic Principles in the Industrial Hygiene World, 9th International Occupational Hygiene Association International Scientific Conference, Kuala Lumpur, 17 September, 2012

29. Invited Speaker and Co-Chairman, 8 th Congress of Toxicology in Developing Countries. Bangkok, Thailand 10-14 September 2012

30. Invited Speaker, Natural Compounds 2012: Regulators of Cell Signaling Pathways and Novel Therapeutic Tools, Luxembourg, 25-27 January 2012.

31. Invited Speaker, 3 rd Global Quality Assurance Conference (3 rd GQAC), Kyoto, Japan, 13-16 November 2011. (Country Representative)

32. Guest Speaker, Occupational Health & Industrial Hygiene Community of Practice (OH & IHCoP) Forum, 5 July 2011

33. Speaker, 39 th International MEDICHEM Congress on Occupational Environmental Health in the Production and Use of Chemicals, Heidelberg, Germany, 2-8 June 2011.

34. Keynote Speaker, 3 rd Medical Undergraduate Annual Scientific Meeting, Kuala Lumpur, Malaysia, 31 May 2011.

35. Apoptosis/Session Chairman, 50 th Annual Meeting of the Society of Toxicology, Washington D.C., USA, 6-10 March 2011.

36. Invited Speaker, 2 nd International Cancer Research Symposium, Trivandrum, India, 17-21 December 2010.

37. Invited Speaker, 2 nd Asian Conference on Environmental Mutagens, Pattaya, Thailand, 15-18 December 2010.

38. Distinguished Speaker, Inaugural Screening Asia Conference & Exhibition, Singapore, 15-16 November 2010.

39. Guest Speaker, PETRONAS Group HSE Forum. Kota Kinabalu, 8-9 August 2010

40. Invited Speaker, 3 rd National Industrial Hygiene Conference, Kuala Lumpur, Malaysia, 5-6 May 2010.

41. Participant, 49 th Annual Meeting & ToxExpo (2010 Society of Toxicology), Utah, USA, 7-11 March 2010.

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42. Invited Speaker, Asian Symposium on ADMET Profiling in Drug Discovery: Metabolism and Drug Safety, Singapore, 15-16 September 2009.

43. Invited Speaker, The 2009 Benzene Symposium, Munich, Germany, 7-11 September 2009.

44. Participant, eCheminfo Workshop on Predictive ADME Toxicology Medical Sciences Teaching Laboratory, Oxford, UK, 25-31 July 2009.

45. Committee/Session Chairman/Invited Speaker, 7 th COSTAM/SFFR (Asia Malaysia) International Workshop 2009, Langkawi, Malaysia, 9-12 July 2009.

46. Advisor, Pre-Conference Toxicology Workshop – Apoptosis: Mechanism of Cell Death & Therapeutic Implications, Kuala Lumpur, Malaysia, 8 July 2009.

47. Invited Speaker, International Society for the Study of Xenobiotics (ISSX), Bangkok, Thailand, 10- 12 May 2009.

TRAINING AND CERTIFICATIONS

• Occupational and Environmental Toxicology , School of Medicine, University of Colorado Health Sciences Center. July 1999 • Toxicogenomics in the Trenches , SOT 2000 Annual Meeting Continuing Education, Philadelphia, Penn, USA. March 2000 • A Biotechnology Platform for Toxicology , IUTOX 2001 Continuing Education, Brisbane, Australia. July 2001 • Molecular Biology in Postgenomic Era , University of Osaka, Japan. March 2003 • International Workshop on Toxicology Towards Diplomate of American Board of Toxicology (DABT) (Mid-America Toxicology Course), Bangalore, India. October 2007 • Chemical Safety Management under REACH , RIVM-IRAS, Bilthoven, Netherlands. January 2009 • Intermediate GHS Training and Chemical Health Risk Assessment , Department of Occupational Safety and Health, Bangi, Malaysia. April 2009 • OECD GLP Training Pharmaceutical Services Corporation (Singapore), Melaka Biotechnology Corporation, July 2009 • eCheminfo Workshop on Predictive ADME Toxicology , Oxford University, UK. July 2009 • Technologies and Tools for Toxicity Testing in the 21 st Century, SOT 2010 Annual Meeting and ToxExpo Continuing Education Course, Salt Lake City, Utah, USA March 2010 • Essentials of Leadership Programme, Centre for Management Development, London Business School. Genting Highlands, Malaysia May 11-13, 2010 • Protecting Human Health : Use of Toxicological and Epidemiological Data in Determining Safe Levels for Human Exposure. SOT 2011 Annual Meeting and ToxExpo Continuing Education Course, Washington DC, USA March 2011

Open • Improving Public Sector Performance : Challenges, Strategies and Results. Conducted by Dr Robert D. Behn (Harvard Kennedy School). Ministry of Higher Education and Harvard Alumni Club. Bandar Enstek, . May 17-18, 2012 • The REACH Regulation and Safety Assessment Approaches for Chemicals That Come in Contact with the Skin , SOT 2013 Annual Meeting and ToxExpo Continuing Education Course, San Antonio, Texas, USA March 2013 • Assessor Training for Programme Accreditation, Malaysian Qualifications Agency 19-21 November 2014 • HSE Tier 3 Assurance Course, Proactive Control and PETRONAS, 16021 August 2015 • Leadership Excellence at PETRONAS Program conducted by The Works Partnership (TWP), PETRONAS Leadership Centre, Bangi, Selangor, Malaysia Sep-Dec 2015 • Water Security: Integrating Lessons Learned for Water Quality, Quantity and Sustainability, International Union of Toxicology and the Brazilian Society of Toxicology, 4-6 November 2015, Natal, Brazil • Kelvin Top-SET 1-day Investigator Course, Bangi, Selangor, Malaysia 21 July 2016 • OPITO T-BOSIET Offshore Safety Passport (valid thru 30-3-2021)

PUBLICATIONS

H-index =18, Citations=711 Journals (*corresponding author)

1. Cain, K*., Inayat-Hussain, S.H. , Wolfe, J.T. and Cohen, G.M. (1994) DNA fragmentation into 200-250 and/or 30-50 kilobase pair fragments in rat liver nuclei is stimulated by Mg 2+ and Ca 2+ /Mg 2+ but not by Ca 2+ alone. Federation of European Biochemical Societies Letters 349, 385-391.

2. Cain, K.*, Inayat-Hussain, S.H ., Kokileva, L. and Cohen, G.M. (1994) DNA cleavage in rat liver nuclei activated by Mg 2+ or Ca 2+ + Mg 2+ is inhibited by a variety of structurally unrelated inhibitors. Biochemistry and Cell Biology 72 , 631-638

3. Cain, K.*, Inayat-Hussain, S.H ., Kokileva, L. and Cohen, G.M. (1995) Multi-step DNA cleavage in rat liver nuclei is inhibited by thiol reactive agents. Federation of European Biochemical Societies Letters 358, 255-261.

4. Cain, K,* Inayat-Hussain, S.H ., Couet, C, Cohen, G.M. (1996) A cleavage site-directed inhibitor of interleukin-1ß-converting enzyme-like proteases inhibits apoptosis in primary cultures of rat hepatocytes. Biochemical Journal 314 , 27-32

5. Cain, K,* Inayat-Hussain, S.H ., Couet, C, Qin, H-M, Oberhammer, F.A. (1996) A novel method for detecting apoptosis shows that hepatocytes undergo a time dependent increase in DNA cleavage and chromatin condensation which is augmented after TGF-ß1 treatment. Cytometry, 23, 312-321

Open 6. Oberhammer, F*., Froschl, G., Tiefenbacher, R., Inayat-Hussain, S.H. , Cain, K. and Stopper, H. (1996) Hepatocyte death following transforming growth factor-ß1 addition. Microscopy Research and Technique, 34, 3, 247-258.

7. Inayat-Hussain, S.H ., Couet, C, Cohen, G.M. and Cain, K.* (1997) Processing/activation of CPP32-like proteases is involved in transforming growth factor-ß1 induced apoptosis in hepatocytes. Hepatology , 25, 1516-1526.

8. Inayat-Hussain, S.H .*, Cohen, G.M. and Cain, K. (1998) Mn 2+ activates DNA cleavage in rat liver nuclei. Asia Pacific Journal of Molecular Biology and Biotechnology , 6, 2 , 67-73

9. Inayat-Hussain, S.H .*, Osman, A.B., Din, L.B., Ali, A.M., Snowden, R.T., MacFarlane, M., Cain, K. (1999) Caspases-3 and -7 are activated in goniothalamin-induced apoptosis in human Jurkat T- cells . Federation of European Biochemical Societies Letters 13 ;456(3):379-83

10. Inayat-Hussain S.H.* (1999) Liver apoptosis. Asia Pacific Journal of Molecular Biology and Biotechnology 7(2): 97-107 (review)

11. Syarif, SL*, Uttaman, A, Jamal Hisham, H, Inayat-Hussain, SH , Jamil, MRM (1999) The effect of pesticide on the activity of serum cholinesterase and current perception threshold on the paddy farmers in the Muda Agricultural Development Area, MADA, , Malaysia. Medical Journal of Malaysia 54 (3): 320-324

12. Inayat-Hussain, S.H .*, Cohen, G.M. and Cain, K (1999) A reappraisal of the role of zinc in TGF-B1 induced apoptosis in hepatocytes . Cell Biology and Toxicology 15 (6), 381-387

13. Inayat-Hussain, SH, McGuinness S.M., Johansson, R., Lundstrom, J. and Ross, D.* (2000) Caspase- dependent and -independent mechanisms in apoptosis induced by hydroquinone and catechol metabolites of remoxipride in HL-60 cells. Chemico-Biological Interactions 128 (1), 51-63

14. Ali, AM,* Umar-Tsafe, N., Mohamad, SM, Oo, KT, Yusoff, K., Dhaliwal, J, Abdullah, N, Din, LB and Inayat-Hussain, SH (2000) Cell cycle and apoptosis induction by goniothalamin in CEM-SS T- lymphoblastic leukemia cell line. Journal of Biochemistry, Molecular Biology and Biophysics 5, 1- 9.

15. Inayat-Hussain, S.H.*, Winski, SL, Ross, D (2001) Differential involvement of caspases in hydroquinone-induced apoptosis in human leukemic HL-60 and Jurkat cells. Toxicology and Applied Pharmacology 175, 95-103.

16. Inayat-Hussain SH *, Annuar BO, Din LB and Taniguchi N (2002) Altholactone, A Novel Styryl- Lactone Induces Apoptosis Via Oxidative Stress In Human HL-60 Leukemia Cells. Toxicology Letters 131, 153-159.

17. Inayat-Hussain, SH ,* Osman, AB, Din, LB, Ali, AM and Ross, D (2003) Loss of mitochondrial transmembrane potential and caspase-9 activation during apoptosis induced by the novel styryl- lactone goniothalamin in HL-60 leukemia cells. Toxicology In Vitro 17, 433-439.

Open 18. Inayat-Hussain, S.H *. and Thomas, N (2004) Recent Advances In The Discovery And Development Of Lactones And Stilbenes In Anticancer Therapy. Expert Opinion on Therapeutic Patents 14 (6):819-835 (review)

19. N.F. Rajab,T.A. Yaakob, B.Y.Ong,M.Hamid, A.M.Ali, B.O. Annuar, S.H. Inayat-Hussain . (2004) DNA damage evaluation of hydroxyapatite on fibroblast cell L929 using the single cell gel electrophoresis assay. Medical Journal of Malaysia , 59(Suppl B): 170-171.

20. Inayat-Hussain ,S.H .*, N.F. Rajab, H. Roslie, A.A. Hussin, A.M. Ali, B.O.Annuar. (2004) Cell Death Induced by Hydroxyapatite on L929 Fibroblast Cells. Medical Journal of Malaysia , 59(Suppl B): 176-177.

21. Inayat-Hussain, SH * and Ross, D (2005) Differential involvement of the mitochondrial/caspase-9 dependent apoptotic pathway in hydroquinone treated HL-60 and Jurkat leukemia cells. Chemical Research in Toxicology 18(3):420-7.

22. Dehn, DL, Inayat-Hussain, SH & Ross D * (2005) RH1 induces cellular damage in an NQO1- dependent manner:Relationship between DNA cross-linking, cell cycle perturbation and apoptosis. Journal of Pharmacology and Experimental Therapeutics . 313(2): 771-9.

23. Rajab, NF *, Hamid, Z, Hassan,H, Ali, AM, Din, LB & Inayat-Hussain, SH (2005) Evaluation of the cytotoxic and genotoxic effects of goniothalamin in leukemic cell lines. Environmental Mutagen Research 27; 161-164

24. Yip FW, Farina Y, Teoh SG, Inayat-Hussain SH, Yamin BM, Baba I & Ali AM (2006) Effect of Additional Methylene Groups of Triphenyltin(IV) Complex Derivatives of Dicarboxylic Acids on Cytotoxicity Tests on Human Promyelocytic Leukemic Cells and 119 Sn NMR Resonance, Malaysian Journal of Pharmaceutical Sciences , 4(2): 33-47

25. Chan, K.M., Rajab, N.F., Ishak, M.H.A., Ali, A.M., Yusoff, K., Din, L.B. & Inayat-Hussain, S.H .* (2006) Goniothalamin induces apoptosis in vascular smooth muscle cells. Chemico-Biological Interactions 159(2): 129-40

26. Zafar, KS , Inayat-Hussain, SH, Siegel, D, Bao, A, Shieh, S & Ross, D * (2006) Overexpression of NQO1 protects human SK-N-MC neuroblastoma cells against dopamine-induced cell death. Toxicology Letters 166(3); 261-267

27. Siew EL, Rajab, NF, Annuar, BO, Sudesh, K, Inayat-Hussain, SH * (2007) In vitro biocompatibility Evaluation Of Poly(3-Hydroxybutyrate-Co- 4-Hydroxybutyrate) [P(3HB-Co-4hb) Copolymer In Fibroblast Cells. Journal of Biomedical Materials Research A 81(2):317-325

28. Inayat-Hussain SH *., Lubis, SH, Ghazali, R, Sakian, NI., Ghazali, AR, Ali, NS, Sersi, EM, Lee, MT, Zainab, AM, Hashim, S, Ghazali, MS, Saidin, MN, Ab Rahman, AR, Rafaai, MJM, Omar, S, Rapiai, R, Othman, R, Chan, TL, Johari, A, Soon, WH, (2007) Is beta-glucuronidase a novel biomarker for anticholinesterase poisoning? A Malaysian experience. Toxicology and Applied Pharmacology ; 219(2-3):210-6.

Open 29. Zafar, KS , Inayat-Hussain, SH & Ross, D * (2007) A comparative study of proteasomal inhibition and apoptosis induced in N27 mesencephalic cells by dopamine and MG132. Journal of Neurotoxicology 102(3):913-21.

30. Lubis SH *, El Sersi M, Inayat-Hussain SH , Sakian NI, Salleh R, Rafai J, Al Khamesey K. (2008) A biomarker for exposure to organophosphate and carbamate pesticides. Asia Pac J Public Health. 2008 Oct; 20 Suppl:162-5.

31. Siew EL , Rajab, NF, Annuar, BO, Sudesh, K, Inayat-Hussain, SH* (2009) In vitro genotoxicity evaluation of Poly(3-Hydroxybutyrate-Co- 4-Hydroxybutyrate) [P(3HB-Co-4hb) Copolymer In Salmonella typhimurium and chinese hamster V79 lung fibroblasts . Journal of Biomedical Materials Research A 91(3):786-794

32. Inayat-Hussain SH *, Wong LT, Chan KM, Rajab NF, Din LB, Harun R, Kizilors A, Saxena N, Mourtada- Maarabouni M, Farzaneh F, Williams GT (2009) RACK-1 overexpression protects against goniothalamin-induced cell death. Toxicol Lett. 191(2-3):118-22.

33. Inayat-Hussain SH *, Ibrahim HA, Siew EL, Rajab NF, Chan KM, G T Williams, Ross D. (2010) Modulation of the benzene metabolite hydroquinone induced toxicity: Evidence for an important role of fau. Chem Biol Interact. 184(1-2):310-312

34. Inayat-Hussain SH *,, Chan KM, Rajab NF, Din LB, Chow SC, Kizilors A, Farzaneh F, Williams GT. (2010) Goniothalamin-induced oxidative stress, DNA damage and apoptosis via caspase-2 independent and Bcl-2 independent pathways in Jurkat T-cells. Toxicol Lett. 193(1):108-114

35. Chan KM, Rajab NF, Siegel D, Din LB, Ross D, Inayat-Hussain SH * (2010) Goniothalamin induces coronary artery smooth muscle cells apoptosis: the p53-dependent caspase-2 activation pathway. Toxicol Sci . 116(2):533-548.

36. Arias-Barreiro CR, Okazaki K, Koutsaftis A, Inayat-Hussain SH , Tani A, Katsuhara M,Kimbara K & Mori IC (2010) A Bacterial Biosensor for Oxidative Stress Using the Constitutively Expressed Redox-Sensitive Protein roGFP2. Sensors 10 , 6290-6306.

37. Kee, CH, Ariffin, A, Awang, K, Takeya, K, Morita, H, Inayat-Hussain S , Chan, KM, Wood, PJ, Threadgill, MD, Lim, CG, Ng, SW, Weber, JFF & Thomas NF (2010) Challenges associated with the synthesis of unusual o-carboxamido stilbenes by the Heck protocol:Intriguing substituent effects, their toxicological and chemopreventive implication. Org. Biomol. Chem ., 2010, 8, 5646–5660

38. Hasiah AH, Ghazali AR *, Weber J, Velu S, Thomas N, Inayat Hussain SH (2011) Cytotoxic and antioxidant effects of methoxylated stilbene analogues on HepG2 hepatoma and Chang liver cells. Hum Exp Toxicol . 30(2): 138-4

39. Roslie, H, Chan, KM, Rajab, NF, Velu, SS, Illah, S, Bunyamin, S, Weber, JFF, Thomas, NF, Majeed, ABA, Myatt, G & Inayat-Hussain SH * (2012) 3,5-Dibenzyloxy-4’-hydroxystilbene induces early caspase-9 activation during apoptosis in human K562 chronic myelogenous leukemia cells. J. Tox Sci 2012;37(1):13-21.

Open 40. Chan KM*, Hamzah R, Rahaman AA, Jong VYM, Khong HY, Rajab NF, Ee GCL & Inayat-Hussain SH (2012) The pyranoxanthone Inophyllin a induces oxidative stress mediated-apoptosis in Jurkat T lymphoblastic leukemia cells. Food Chem Tox 50(8):2916-22.

41. Siew, EL, Chan, KM, Williams, GT, Ross, D & Inayat-Hussain, SH* (2012) Protection of hydroquinone-induced apoptosis by downregulation of fau is mediated by NQO1. Free Rad Biol Med ;53(8):1616-24

42. Orlikova B, Schumacher M, Juncker T, Yan CC, Inayat-Hussain SH , Hajjouli S, Cerella C, Dicato M, Diederich M*. (2013) Styryl-lactone goniothalamin inhibits TNF-α-induced NF-κB activation. Food Chem Toxicol . 59:572-8.

43. Yen HK, Fauzi AR, Din LB, McKelvey-Martin VJ, Meng CK, Inayat-Hussain SH , Rajab NF* (2014) Involvement of Seladin-1 in goniothalamin-induced apoptosis in urinary bladder cancer cells. BMC Complement Altern Med . 14:295

44. Mori IC*, Arias-Barreiro CR, Koutsaftis A, Ogo A, Kawano T, Yoshizuka K, Inayat-Hussain SH , Aoyama I (2015) Toxicity of tetramethylammonium hydroxide to aquatic organisms and its synergistic action with potassium iodide. Chemosphere . 120:299-304

45. Chow PW, Abdul Hamid Z, Chan KM, Inayat-Hussain SH, Rajab NF*. (2015) Lineage-related cytotoxicity and clonogenic profile of 1,4-benzoquinone-exposed hematopoietic stem and progenitor cells. Toxicol Appl Pharmacol . 284(1):8-15

46. Inayat-Hussain SH *, Fukumura M, Aziz AM, Chai MJ, Low WJ, Garcia-Milian R, Vasiliou V, Deziel NC (2018) Prioritization of Reproductive Toxicants in Unconventional Oil and Gas Operations Using a Multi-Country Regulatory Data-Driven Hazard Assessment. Environment International . 117:348-358

47. Perkins AL, Inayat-Hussain SH , Deziel NC, Johnson CH, Ferguson SS, Boyles AL, Garcia-Milian R, Thompson DC and Vasiliou V (2018) Evaluation of Potential Carcinogenicity of Organic Chemicals in Synthetic Turf Crumb Rubber. Environmental Research (accepted, https://doi.org/10.1016/j.envres.2018.10.018 )

Chapters in Book/Chapter in Encyclopedia

1. Lubis, S.H., Hashim, J.H., Ismail, N.H. and Inayat-Hussain, S.H. (1998) Pattern of diseases among rice farmers exposed to pesticides in the Muda Area, p.192-9, In: Rice Agroecosystem of the Muda irrigation Scheme Malaysia . B.M. Nashriyah, N.K. Ho, B.S. Ismail, A.B. Ali and K.Y. Lum. (Eds) MINT-MADA, Malaysia 256pp

2. Satoh, T and Inayat-Hussain, S.H. (2002) Environmental Toxicology and Human Health in Knowledge For Sustainable Development - An Insight into the Encyclopedia of Life Support Systems Vol. II; section 11.4 , pp757-780, UNESCO Publishing/ EOLSS Publishers, Paris, France, Oxford, UK

Open 3. Lubis, SH, Abdullah, U, Abdul Ghani, NH , Jamil, MRM, Inayat-Hussain SH (2002) The Current Perception Threshold (CPT) among rice farmers in Muda, Kedah, and fishermen in Setiu, Terengganu. p155-160, In: Sustainable Rice Production In Malaysia Beyond 2000 Institut Penyelidikan Teknologi Nuklear Malaysia (MINT) and Muda Agricultural Development Authority (MADA)

4. Inayat-Hussain SH , Siew EL, Rajab NF (2008) In vitro toxicity testing as a predictive tool for safety evaluation of biomaterials. (chapter 20 in Cellular Response to Biomaterials , CRC Press & Woodhead Publishing Limited, UK) pp 508-537

5. Inayat-Hussain SH , Bakar JA, Ibrahim E, Mokhtar M and Nunis MA (2009) Malaysia (chapter 96 in Information Resources in Toxicology , Elsevier and AP Press ) pp1003-1013

6. Satoh T, Inayat-Hussain SH , Kamishima M and Ueyama J (2010) Novel Biomarkers of Organophosphate Exposure (chapter 21 in Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, Wiley-VCH).

7. Ghazali, AR , Inayat-Hussain SH (2014) N,N-Dimethylacetamide. In: Wexler, P. (Ed.), Encyclopedia of Toxicology, 3rd edition vol 3. Elsevier Inc., Academic Press, pp. 594–597 .

8. Faustman, EM, Foth, H, Umbuzeiro, GA, Barros, SM, Smith, MN, Navoni, JA, Schiesari, L & Inayat-Hussain, SH (2018) 4.1 Water Security: Integrating Lessons Learned for Water Quality, Quantity and Sustainability. In Global Change and Future Earth: The Geodetic and Geophysical Perspective (Monograph) Cambridge University Press. In press

SELECTED SUPERVISORY/EXAMINER EXPERIENCE

Postdoctoral supervision

1. Dr Chakra Reddy (2010-2011) Postdoctoral fellow, Universiti Kebangsaan Malaysia (UKM) 2. Dr Shoeb Zafar Khan (2004) Postdoctoral fellow, University of Colorado Health Sciences Center 3. Dr Shieh Bie-Huoy (2004) Postdoctoral fellow, University of Colorado Health Sciences Center

Postgraduate supervision Doctor of Philosophy 1. Dr Chan Kok Meng (2009) Universiti Kebangsaan Malaysia Mechanisms of Styryllactone induced Apoptosis. Current position: Head, Environmental Health Program & Associate Professor of Toxicology, Faculty of Health Sciences, Universiti Kebangsaan Malaysia Main Supervisor

2. Dr Siew Ee Ling (2015) Universiti Kebangsaan Malaysia Molecular Mechanisms of Benzene Toxicity. Current position: Product Scientist at Interscience Sdn Bhd Main Supervisor

Open

3. Ms Nor Rahmah Nor Hashim (2015-present) Colorado School of Public Health Exposure and health risk assessment of air emissions from petroleum/petrochemical facilities. Current Position: Staff, Industrial Hygienist, PETRONAS (on study leave for PhD) Doctor of Public Health Thesis Committee

4. Ms Maihani Ismail (2018-present) Kyoto University, Japan Environmental health risk assessment of emissions surrounding Melaka Petroleum Refinery Current position: Environmental Health Executive, Toxicology Dept, Group HSE PETRONAS ( on study leave for PhD) Co- supervisor

Masters

5. Mr Khor Tin Oo (2001) Universiti Putra Malaysia Characterisation of plant derived damnacanthal and nordamnacanthal induced cytotoxicity on human HT29 Colon Adenocarcinoma cell line. Current position: Research Scientist at MD Anderson Cancer Research Center, Houston, Texas Co-supervisor

6. Ms Siew Ee Ling (2008) Universiti Kebangsaan Malaysia In vitro toxicological assessment of degradable biomaterials. Current position: Product Scientist at Interscience Sdn Bhd Main Supervisor

7. Mr Haslan Roslie (2012) Universiti Teknbologi MARA Molecular mechanisms of stilbene derivatives induced apoptosis Current position: Research Officer at Universiti Malaysia Sarawak. Main Supervisor

8. Ir Mokhtar Sabtu (2013) Universiti Kebangsaan Malaysia Assessment of biomarkers of benzene exposure and effect in petrochemical workers. Current position: Factory and Machinery Inspector, Dept of Occupational Safety and Health, Selangor Main Supervisor

9. Ms Ruhana Hamzah (2015) Universiti Kebangsaan Malaysia The role of Fau and NQO1 in Goniothalamin-induced cytotoxicity on Glioblastoma Multiforme Current position: Teacher Co-supervisor

10. Ms Maihani Ismail (2018) Kyoto University, Japan Environmental health risk assessment of emissions surrounding Melaka Petroleum Refinery

Open Current position: Environmental Health Executive, Toxicology Dept, Group HSE PETRONAS (on study leave for PhD) Co- supervisor

Thesis examiner 1. External examiner for UPM (1 PhD and 1 Master’s thesis) 2. External examiner for USM (1 PhD thesis) 3. Internal examiner for UKM (2 Master’s theses)

Academic Examiner 1. External examiner for professorial promotion for USM & UMT academicians 2. Senate member for professorial promotion in UKM

RESEARCH GRANTS

No. Title Place Status Financial Support

1 Characterization of the MRC Toxicology Completed UKM and MRC mechanisms of TGF-ß1 Unit and University (Doctor of induced apoptosis in of Leicester, UK Philosophy primary hepatocytes (1993-1997) research) 2 Molecular mechanisms of MRC Toxicology Completed MRC and goniothalamin induced Unit and University (Project Wellcome Trust apoptosis in leukemia cells of Leicester, UK Leader ) (1999)

3 Identification and Faculty of Allied Completed IRPA (09-02-02- evaluation of structure, Health Sciences, (joint project) 0021) bioactive agents and UKM consumption of local sea- (1998-1999) cucumbers 4 Screening for antiviral, Faculty of Food Completed IRPA (03-03-04- anticancer, antinematode Science and (joint project) 05) and antimicrobial Biotechnology, activities of medicinal UPM plants of the and (1998-2000) Orang Asli 5 NQO1 protection in School of Completed NIH (5ROI benzene toxicity Pharmacy, (Head, ES09554) University of Apoptosis Research

Open Colorado Health Sciences Center (1999-2000) 6 Mechanistic Studies on School of Completed AstraZeneca Aplastic Anemia Pharmacy, (Head, University of Apoptosis Colorado Health Research) Sciences Center (1999-2000) 7 Safety evaluation of SIRIM and Faculty Completed IRPA (09 -01 -01 - indigenous cosmetic of Science and (Joint project) 0021) ingredients Technology, UKM (1999-2000) 8 Role of oxidative stress in Dept of Completed Nippon Trust altholactone induced Biochemistry, (Project Bank Limited apoptosis in HL-60 human University of Osaka Leader ) leukemia cells Medical School (2000) 9 Synthesis, characterization Faculty of Science Completed IRPA (09 -02 -02 - & biological activity study and Technology, (Joint project; 0133) of new oxygen and UKM and Faculty of involved in sulphur chelated Allied Health toxicology organotins Sciences, UKM assessment) (1999-2003) 10 Biological Assessment of Faculty of Allied Completed IRPA (03 -02 -02 - Bone Graft Substitutes Health Sciences, (Head of 0035PR) (Top down Project: UKM and Faculty of Research Biomaterials for Medical Science and Group; Applications) Technology, UKM involved in (2002-2005) cytotoxicity and apoptosis) 11 Effects of Tocotrienol on Faculty of Medicine Completed IRPA (06 -02 -02 - Oxidative Stress and and HUKM, Faculty (Joint project: 0026PR) Inflammation In Patients of Allied Health involved in with IHD and Sciences, UKM oxidative stress Hypercholesterolemia (2002-2005) assessment) 12 Effect of local natural Faculty of Completed IRPA (06 -02 -04 - products such as Medicine, HUKM (Joint project: 0374-PR0014/06- goniothalamin on cellular and Faculty of involved in 05) proliferation and Allied Health mechanisms of apoptosis induction Sciences, UKM apoptosis) pertaining to coronary (2002-2005) artery restenosis post- angioplasty. 13. Japan Society for Malaysia Completed JSPS -VCC Promotion of Science UKM, USM, (Joint project (JSPS) – Malaysian Vice- KUSTEM & UM between

Open Chancellors’ Council (VCC) Japan Malaysia & Ten Year Research Kyoto University & Japan Programme Okayama Environmental Science, University Ethics and Engineering: (2000-2009) Towards Zero Discharge Society: 2000- 2009 (Group: Environmental Toxic Evaluation & Management & Risk Assessment) 14 Molecular and University of Completed NIH (NCI) RO1 Biochemical Studies on Colorado (Leading the CA51210 (12-16) DT-diaphorase (2004) Apoptosis Research) 15 NQO1, oxidative stress University of Completed NIH (NINDS) RO1 and proteasomal Colorado (Headed the NS44613 (01-05 inhibition (2004) Apoptosis Research) 16 Molecular Mechanism of Universiti Completed SAGA-Academy Goniothalamin induced Kebangsaan (Project of Science, apoptosis on vascular Malaysia Leader ) Malaysia smooth muscle cells as a (2005-2007) model for restenosis postangioplasty 17 Assessment of Universiti Completed Kurita Water and environmental genotoxins Kebangsaan (Project Environment in industrial wastewater Malaysia Leader ) Foundation and river (2005-2006) (Japan)

18 Analysis of the molecular Universiti Completed The Wellcome mechanisms controlling Kebangsaan (Project Trust (UK) the induction of apoptosis Malaysia, Keele Leader ) by natural styryllactones University and including goniothalamin King’s College London (2005-2009) 19 Molecular mechanisms of Universiti Completed Third World styryllactone induced Kebangsaan (Project Academy of apoptosis Malaysia Leader ) Sciences (Italy) (2005-2007) 20. Molecular mechanisms of Universiti Completed UKM Medical the antitumor quinone Kebangsaan (Project Molecular RH1 induced apoptosis Malaysia and Leader) Biology University of Fundamental Grant

Open Colorado Health Sciences Center (2005-2006) 21 Biomonitoring of Universiti Completed Muda pesticides toxicity using Kebangsaan (Project Agricultural beta-glucuronidase as a Malaysia, Leader ) Development novel biomarker in plasma International Authority of exposed farmers Islamic University of Malaysia, Chiba University & Muda Agriculture Development Authority (MADA) (2005-2006) 22 In vitro cytotoxic and Universiti Completed Q-Nutrient Pte apoptotic effects of novel Kebangsaan (Project Ltd microbial fermentation Malaysia Leader ) products Oncogen XP180 (2006) and Oncolyn

23 Mutagenicity Testing Universiti Completed MOSTI facility in Accordance with Kebangsaan (Project OECD Principles of Good Malaysia and Leader) Laboratory Practice Melaka Melaka Biotechnology Corporation (2007- 2011) 24 Design, Synthesis and Universiti Completed MOSTI Pharmacological Kebangsaan (Project Leader Properties of Styryl Malaysia, Universiti in UKM) Derivatives, Their Teknologi Mara & Chelated Cyclen (1,4,7,10- Universiti Malaya Terazacyclododecane)- (2006-2009) Bound Analogues and Oligomers 25 Analysis of The Molecular Universiti Completed UKM Research Mechanisms Controlling Kebangsaan (Project University Grant the Induction of Apoptosis Malaysia, Leader) by Benzene Derived University of Quinone Colorado & University of Keele, UK (2008-2012) 26 Role of Fau and NQ01 in Universiti Completed HiCOE Grant, Glioblastoma Multiforme Kebangsaan (Project Ministry of (GBM) and Colorectal Malaysia, Leader) Higher Education Cancer (CRC) University of

Open Colorado & University of Keele, UK (2010-2013) 27 Molecular Mechanism of Universiti Completed ( Co- FRGS Grant, trifluoromethoxy- Kebangsaan researcher) Ministry of Goniothalamin Induced Malaysia Higher Education Apoptosis in Jurkat (2011-2013) Lymphoblastic Cells 28 Understanding Molecular Universiti Completed ( Co - FRGS Grant, Signature of Leukaemia Kebangsaan researcher) Ministry of Stem Cells by targeting Malaysia Higher Education Genes Regulating (2011-2013) Hematipoietic Stem Cells Fate: Benzene as a Model 29 The Relationship between Universiti Completed PETRONAS Biomarker and Genetoxic Kebangsaan (Project Penapisan Effects of Low Air Levels of Malaysia (2011- Leader ) Terengganu Sdn Benzene exposure among 2012) Bhd, Aromatics Petrochemical Workers Malaysia Sdn Bhd & UKM

Open http://www.mysot.org.my Tel: +60 3 9289 8118 Fax: +60 3 2698 7832

15 November 2018 Prof. Dr. Herman Autrup Chair of the Nominating CommitteeIUTOX

Dear Prof. Faustman,

NOMINATION: DR. SALMAAN HUSSAIN INAYAT-HUSSAIN FOR THE DIRECTOR POSITION

On behalf of Malaysian Society of Toxicology, it is my pleasure to nominate Dr. Salmaan Hussain Inayat-Hussain for IUTOX Director position for the 2019-2022 term. He is an outstanding nominee for the position in which he has a long list of success. I recommend him to you highly.

Dr. Inayat-Hussian is a registered toxicologist under EuroTox and a Diplomate of the American Board of Toxicology. He is also a Fellow of Academy of Sciences, Malaysia. He has facilitated the advancement of toxicology in Malaysia whereby he is the founding President for the Malaysian Society of Toxicology. His has a vast contribution towards nation development and one of it was that he was directly involved in the establishment of the DOSH guideline on mercury management in oil and gas industry. In addition, he has helped the Melaka State Government where he was appointed as the Scientific Adviser to the Chief Minister and has established the first GLP accredited lab for mutagenicity testing in the state. He is currently serves as an Advisor to the Department of Occupational Safety and Health and National Professors’ Council. Dr. Inayat-Hussain was a Professor of Toxicology and Dean of the Faculty of Health Sciences prior to joining PETRONAS. In 2013, he joined PETRONAS as the Chief Toxicologist where he pioneered the area of toxicology in PETRONAS. He is currently the Head of Global Toxicology Department within the Group Health, Safety & Environment Division which he has established in PETRONAS. Dr. Inayat-Hussain is also recognised internationally for his scientific contribution where he is appointed as an Advisor for the World Health Organization (WHO) on the Development of Chemical Risk Assessment Toolkit, Risk Assessment trainer for APEC Chemical Regulators and he is the only Malaysian as an Expert Panel member of the Joint FAO/WHO Meeting on Pesticide Residues. He is the current Chair for the IPIECA GHS Task Force and holding a director position for International Union of Toxicology (IUTOX) Executive Committee. He has also been appointed recently as an adjunct professor at Yale University, USA.

Dr. Inayat-Hussain continued to produce impact research although he was committed with his administrative duties as the Head of Global Toxicology Department until very recently. He has published numerous toxicology related articles over the years. He is currently the associate editor for Food and Science Toxicology, Journal of Toxicological Sciences, and Human and Experimental Toxicology. His research area mainly focuses on understanding the toxicity of chemicals in the environment and workplace. I’m confident in saying that his research work is of high quality.

President, MySOT (Email: [email protected] ) Environmental Health and Industrial Safety Programme, School of Diagnostic & Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia http://www.mysot.org.my Tel: +60 3 9289 8118 Fax: +60 3 2698 7832

Dr. Inayat-Hussain proved himself to be an exemplary and capable mentor. He has supervised numerous undergraduate and postgraduate students, and mentored many young toxicologists in Malaysia. He is clearly able to transmit his passion and talent for research to young scientists. I was especially taken by Prof. Salmaan’s passion and work ethic where he managed to spend time to troubleshoot method and discuss research direction despite his busy schedule. He handled responsibility well, was resourceful, and took initiative to maintain and ensure that safety standards were met. He took on many of the responsibilities of a toxicologist and excelled in everything he did.

For these reasons, I highly recommend Dr. Salmaan Hussain Inayat-Hussain for the IUTOX director position. I can assure that with Dr. Inayat-Hussain’s vast experience in science and management, without any doubt, he can contribute to the IUTOX and more importantly he will be the ambassador for the Malaysian Society of Toxicology and the South East Asia countries.

Please contact me if there is anything else I can do on his behalf.

Yours sincerely,

Chan Kok Meng, PhD President Malaysian Society of Toxicology

President, MySOT (Email: [email protected] ) Environmental Health and Industrial Safety Programme, School of Diagnostic & Applied Health Sciences, Faculty of Health Sciences, Universiti Kebangsaan Malaysia Jalan Raja Muda Abdul Aziz, 50300 Kuala Lumpur, Malaysia