Datasheet Inhibitors / Agonists / Screening Libraries A DRUG SCREENING EXPERT

Product Name : -3-O-glucoside chloride Catalog Number : TN1909 CAS Number : 7228-78-6 Molecular Formula : C23H25ClO12 Molecular Weight : 528.90

Description: Malvidin 3-glucoside has antioxidant activity, alone is not oxidized in the presence of grape polyphenol oxidase. Malvidin 3-glucoside's color stabilization at a higher pH can be explained by self-aggregation of the flavylium cation and with the Z-chalcone form.

Storage: 2 years -80°C in solvent; 3 years -20°C powder;

Receptor (IC50) others

In vitro Activity Here we used a gel electrophoresis assay employing supercoiled DNA plasmid to examine the ability of these compounds (1) to intercalate DNA, (2) to inhibit human topoisomerase I through both inhibition of plasmid relaxation activity (catalytic inhibition) and stabilization of the cleavable DNA-topoisomerase complex (poisoning), and (3) to inhibit or enhance oxidative single-strand DNA nicking. We found no evidence of DNA intercalation by anthocyan(id)ins in the physiological pH range for any of the compounds used in this study- chloride, cyanidin 3-O-glucoside, cyanidin 3,5-O-diglucoside, Malvidin-3-O-glucoside chloride and luteolinidin chloride. The inhibited topoisomerase relaxation activity only at high concentrations (> 50 muM) and we could find no evidence of topoisomerase I cleavable complex stabilization by these compounds.

Reference 1. Interactions with DNA: Intercalation, Topoisomerase I Inhibition and Oxidative Reactions.J Food Biochem. 2008 Sep 23;32(5):576-596.

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