Table S4. TCOF1 related genes calculated by Genedeck database involved in different biological process analysed by DAVID database List Pop Pop Fold Term P Value Genes Bonferroni Benjamini FDR Total Hits Total Enrichment
GO:0010604~positive regulation of 1.67E-70 MEF2C, HRAS, THRB, STAT5A, STAT5B, SNCA, TGFB3, CASK, TLR4, TBP, CBFB, TGFB1, ZIC3, 481 857 13528 5.119556 6.48E-67 6.48E-67 3.09E-67 macromolecule metabolic process CITED2, TGFB2, APOE, GATA4, H2AFX, RARB, MLL4, CCNA2, INSR, SYK, RARG, MYO6, RXRA,
PPARGC1A, IRS1, HES1, HHEX, MAPK1, EP300, HES5, JUN, SIX1, VEGFA, MAPK9, CAV1, BLM,
SOX4
GO:0042127~regulation of cell 1.90E-68 NOG, HRAS, IL18, STAT5A, PTGS1, STAT5B, TGFB3, IL13, FGF10, TGFB1, TGFB2, BDNF, MYD88, 481 787 13528 5.289024 7.37E-65 3.69E-65 3.51E-65 proliferation CDKN2A, CDKN2C, APOE, CDKN2D, ILK, GATA4, RARB, CCNA2, INSR, SYK, EGFR, GTPBP4,
RARG, RXRA, EFNB1, IRS1, HES1, PTHLH, HHEX, MAPK1, FGFR1OP, JUN, VEGFA, FOXG1,
PDGFRB, F
GO:0009891~positive regulation of 1.85E-66 MEF2C, HRAS, THRB, STAT5A, STAT5B, TGFB3, CASK, TLR4, TBP, TGFB1, ZIC3, CBFB, CITED2, 481 695 13528 5.584481 7.20E-63 2.40E-63 3.43E-63 biosynthetic process TGFB2, APOE, GATA4, RARB, MLL4, CCNA2, INSR, SYK, EGFR, RARG, MYO6, RXRA,
PPARGC1A, IRS1, HES1, PTHLH, HHEX, MAPK1, EP300, HES5, JUN, SIX1, VEGFA, BLM, SOX4,
ABCA1, SOX9
GO:0031328~positive regulation of 2.16E-65 MEF2C, HRAS, THRB, STAT5A, STAT5B, TGFB3, CASK, TLR4, TBP, TGFB1, ZIC3, CBFB, CITED2, 481 685 13528 5.58389 8.40E-62 2.10E-62 4.00E-62 cellular biosynthetic process APOE, GATA4, RARB, MLL4, CCNA2, INSR, SYK, EGFR, RARG, MYO6, RXRA, PPARGC1A, IRS1,
HES1, PTHLH, HHEX, MAPK1, EP300, HES5, JUN, SIX1, VEGFA, BLM, SOX4, ABCA1, SOX9, SRF,
GO:0051173~positive regulation of 4.29E-64 MEF2C, HRAS, THRB, STAT5A, STAT5B, TGFB3, CASK, TBP, TGFB1, ZIC3, CBFB, CITED2, APOE, 481 644 13528 5.721026 1.67E-60 3.34E-61 7.95E-61 nitrogen compound metabolic process GATA4, H2AFX, RARB, MLL4, CCNA2, INSR, EGFR, RARG, MYO6, RXRA, PPARGC1A, PTHLH,
HES1, HHEX, MAPK1, EP300, HES5, JUN, SIX1, VEGFA, BLM, SOX4, ABCA1, SOX9, SRF, WT1,
ARNT,
GO:0010557~positive regulation of 3.04E-63 MEF2C, HRAS, THRB, STAT5A, STAT5B, TGFB3, CASK, TBP, TLR4, TGFB1, ZIC3, CBFB, CITED2, 481 654 13528 5.633549 1.18E-59 1.97E-60 5.63E-60 macromolecule biosynthetic process TGFB2, GATA4, RARB, MLL4, CCNA2, INSR, SYK, RARG, MYO6, RXRA, PPARGC1A, IRS1, HES1,
HHEX, MAPK1, EP300, HES5, JUN, SIX1, VEGFA, BLM, SOX4, SOX9, SRF, WT1, ARNT, NR1H2, H
GO:0045935~positive regulation of 6.05E-63 MEF2C, HRAS, THRB, STAT5A, STAT5B, TGFB3, CASK, TBP, TGFB1, ZIC3, CBFB, CITED2, APOE, 481 624 13528 5.769177 2.35E-59 3.36E-60 1.12E-59 nucleobase, nucleoside, nucleotide and GATA4, H2AFX, RARB, MLL4, INSR, CCNA2, RARG, MYO6, RXRA, PPARGC1A, PTHLH, HES1, nucleic acid metabolic process HHEX, MAPK1, EP300, HES5, JUN, SIX1, VEGFA, BLM, SOX4, ABCA1, SOX9, SRF, WT1, ARNT,
NR1H2
GO:0010941~regulation of cell death 1.08E-62 MEF2C, XRCC5, HRAS, MAEA, MMP9, STAT5A, STAT5B, SNCA, TGFB3, TLR4, TGFB1, BTK, 481 815 13528 4.969279 4.20E-59 5.25E-60 2.00E-59
CITED2, TGFB2, MAP3K7, BDNF, MYD88, CDKN2A, CD44, HTRA2, CDKN2C, APOE, CDKN2D,
ILK, RARB, FAS, TWIST2, EGFR, RARG, RXRA, FADD, STK4, MAPK1, JUN, VEGFA, RIPK3,
MAPK9, MAPK8, TNF
GO:0043067~regulation of programmed 5.13E-62 MEF2C, XRCC5, HRAS, MAEA, MMP9, STAT5A, SNCA, STAT5B, TGFB3, TLR4, TGFB1, BTK, 481 812 13528 4.953002 1.99E-58 2.21E-59 9.49E-59 cell death CITED2, TGFB2, MAP3K7, BDNF, MYD88, CDKN2A, CD44, HTRA2, CDKN2C, APOE, CDKN2D,
ILK, RARB, FAS, TWIST2, EGFR, RARG, RXRA, FADD, STK4, MAPK1, JUN, VEGFA, RIPK3,
MAPK9, MAPK8, TNF
GO:0010628~positive regulation of gene 5.98E-61 MEF2C, THRB, STAT5A, STAT5B, TGFB3, CASK, TBP, TGFB1, ZIC3, CBFB, CITED2, GATA4, 481 581 13528 5.905711 2.32E-57 2.32E-58 1.11E-57 expression RARB, CCNA2, MLL4, MYO6, RARG, RXRA, PPARGC1A, HES1, HHEX, MAPK1, EP300, HES5,
JUN, SIX1, VEGFA, MAPK9, BLM, SOX4, SOX9, SRF, WT1, ARNT, NR1H2, HOXA1, HOXA2,
NKX2-1, RUNX1, R
GO:0045944~positive regulation of 4.66E-59 MEF2C, THRB, STAT5A, STAT5B, TGFB3, CASK, ZIC3, TGFB1, CBFB, CITED2, GATA4, RARB, 481 371 13528 7.504985 1.81E-55 1.65E-56 8.63E-56 transcription from RNA polymerase II MYO6, RARG, RXRA, PPARGC1A, HES1, HHEX, EP300, HES5, JUN, SIX1, VEGFA, SOX9, SRF, promoter WT1, ARNT, NR1H2, HOXA1, HOXA2, NKX2-1, RUNX1, RUNX2, NKX2-5, BMP4, BMP2, MLL,
MAFB, GRIN1,
GO:0042981~regulation of apoptosis 4.74E-59 MEF2C, XRCC5, HRAS, MAEA, MMP9, STAT5A, SNCA, STAT5B, TGFB3, TLR4, TGFB1, BTK, 481 804 13528 4.862362 1.84E-55 1.54E-56 8.78E-56
CITED2, TGFB2, MAP3K7, BDNF, MYD88, CDKN2A, CD44, HTRA2, CDKN2C, APOE, CDKN2D,
ILK, RARB, FAS, TWIST2, EGFR, RARG, RXRA, FADD, STK4, MAPK1, JUN, VEGFA, RIPK3,
MAPK9, MAPK8, TNF
GO:0045941~positive regulation of 1.18E-57 MEF2C, THRB, STAT5A, STAT5B, TGFB3, CASK, TBP, TGFB1, ZIC3, CBFB, CITED2, GATA4, 481 564 13528 5.834388 4.59E-54 3.53E-55 2.19E-54 transcription RARB, CCNA2, MLL4, MYO6, RARG, RXRA, PPARGC1A, HES1, HHEX, MAPK1, EP300, HES5,
JUN, SIX1, VEGFA, BLM, SOX4, SOX9, SRF, WT1, ARNT, NR1H2, HOXA1, HOXA2, NKX2-1, RUNX1, RUNX2, N
GO:0045893~positive regulation of 6.12E-56 MEF2C, THRB, STAT5A, STAT5B, TGFB3, CASK, ZIC3, TGFB1, CBFB, CITED2, GATA4, RARB, 481 477 13528 6.308904 2.38E-52 1.70E-53 1.13E-52 transcription, DNA-dependent MLL4, MYO6, RARG, RXRA, PPARGC1A, HES1, HHEX, EP300, HES5, JUN, SIX1, VEGFA, SOX4,
SOX9, SRF, WT1, ARNT, NR1H2, HOXA1, HOXA2, NKX2-1, RUNX1, RUNX2, NKX2-5, BMP4,
BMP2, MLL,
GO:0051254~positive regulation of RNA 1.48E-55 MEF2C, THRB, STAT5A, STAT5B, TGFB3, CASK, ZIC3, TGFB1, CBFB, CITED2, GATA4, RARB, 481 481 13528 6.256439 5.75E-52 3.83E-53 2.74E-52 metabolic process MLL4, MYO6, RARG, RXRA, PPARGC1A, HES1, HHEX, EP300, HES5, JUN, SIX1, VEGFA, SOX4,
SOX9, SRF, WT1, ARNT, NR1H2, HOXA1, HOXA2, NKX2-1, RUNX1, RUNX2, NKX2-5, BMP4,
BMP2, MLL,
GO:0006357~regulation of transcription 7.08E-49 MEF2C, THRB, STAT5A, STAT5B, FST, TGFB3, CASK, TGFB1, ZIC3, CBFB, CITED2, GATA1, 481 727 13528 4.681009 2.75E-45 1.72E-46 1.31E-45 from RNA polymerase II promoter GATA4, RARB, TWIST2, IKBKAP, MYO6, RARG, RXRA, RBL1, PPARGC1A, HES1, HHEX, EP300,
HES5, JUN, SIX1, VEGFA, MNX1, TFAP2A, SOX9, SRF, WT1, ARNT, NR1H2, VDR, HOXA1, TAL1,
HOXA2,
GO:0051094~positive regulation of 1.05E-46 XRCC5, THRB, FOXA2, STAT5A, PPARG, STAT5B, FST, PAX6, TGFB3, NFKB1, GLI2, GLI3, 481 278 13528 7.789946 4.09E-43 2.41E-44 1.95E-43 developmental process TGFB1, TGFB2, AKT1, MEN1, ACVR1B, CCNE1, BDNF, ILK, GATA4, RARA, NOS3, NRG1, INSR,
FGF2, SYK, LYN, DLL3, RB1, ACVR2A, CD36, JUN, FOXG1, MAPK9, NGFR, ACVR1, TNF, DRD2,
CSF1, KI
GO:0008284~positive regulation of cell 1.66E-43 NOG, NBN, HRAS, STAT5A, IL18, STAT5B, PAX6, IL13, FGF10, TP63, PAX3, GLI2, TGFB1, TGFB2, 481 414 13528 5.978206 6.45E-40 3.58E-41 3.08E-40 proliferation ILK, TGFA, NRG1, INSR, FGF2, MYC, CCNA2, SYK, EGFR, CDC7, LYN, CCKBR, EFNB1, CDK6,
IRS1, CDK2, PTHLH, HES1, MAPK1, PRKCQ, CCND1, HIPK1, FGFR1OP, JUN, HIPK2, FOXG1, VE
GO:0045597~positive regulation of cell 3.11E-43 XRCC5, THRB, FOXA2, STAT5A, PPARG, STAT5B, PAX6, TGFB3, NFKB1, GLI2, GLI3, TGFB1, 481 229 13528 8.351451 1.21E-39 6.35E-41 5.75E-40 differentiation TGFB2, AKT1, MEN1, ACVR1B, CCNE1, BDNF, ILK, RARA, NRG1, FGF2, SYK, LYN, DLL3, RB1,
ACVR2A, CD36, JUN, FOXG1, MAPK9, NGFR, ACVR1, DRD2, CSF1, KITLG, KIT, SRF, ADA,
ARNT, EPH
GO:0043069~negative regulation of 6.57E-43 XRCC5, MEF2C, HRAS, MAEA, STAT5A, SNCA, STAT5B, TGFB3, TP63, NFKB1, PAX2, PTEN, 481 359 13528 6.424035 2.56E-39 1.28E-40 1.22E-39 programmed cell death CITED2, AKT1, MAP3K7, EDNRB, BDNF, MYD88, APOE, CDKN2D, PAX7, ILK, NOS3, FAS, NRG1, MKL1, CASP2, MYC, TERT, TWIST2, EGFR, CDK1, ESR1, TP53, ESR2, EYA1, PSEN1, HIPK2,
PSEN2, VE
GO:0060548~negative regulation of cell 8.23E-43 XRCC5, MEF2C, HRAS, MAEA, STAT5A, SNCA, STAT5B, TGFB3, TP63, NFKB1, PAX2, PTEN, 481 360 13528 6.406191 3.20E-39 1.52E-40 1.52E-39 death CITED2, AKT1, MAP3K7, EDNRB, BDNF, MYD88, APOE, CDKN2D, PAX7, ILK, NOS3, FAS, NRG1,
MKL1, CASP2, MYC, TERT, TWIST2, EGFR, CDK1, ESR1, TP53, ESR2, EYA1, PSEN1, HIPK2,
PSEN2, VE
GO:0043066~negative regulation of 1.68E-40 XRCC5, MEF2C, HRAS, MAEA, STAT5A, SNCA, STAT5B, TGFB3, TP63, NFKB1, PTEN, CITED2, 481 354 13528 6.276425 6.55E-37 2.98E-38 3.12E-37 apoptosis AKT1, MAP3K7, EDNRB, BDNF, MYD88, APOE, CDKN2D, PAX7, ILK, NOS3, FAS, MKL1, NRG1,
CASP2, MYC, TERT, TWIST2, EGFR, CDK1, ESR1, TP53, ESR2, EYA1, PSEN1, HIPK2, PSEN2,
VEGFA, A
GO:0006468~protein amino acid 1.81E-40 STAT5A, TGFB3, CASK, TGFB1, BTK, TGFB2, CSNK2A2, MAP3K7, CSNK2A1, COL4A3BP, ILK, 481 667 13528 4.469599 7.05E-37 3.07E-38 3.36E-37 phosphorylation PRKACA, INSR, MAP2K7, SYK, EGFR, IKBKAP, RET, STK4, MAPK1, CAMK4, RIPK3, PDGFRB,
ROR2, MAPK9, MAPK8, MAPK7, EIF2AK3, FGFR2, FGFR1, ERBB4, STK11, ERBB3, ERBB2, NEK1,
HUS1, MAP
GO:0035295~tube development 5.00E-40 NOG, FOXA2, TGFB3, TP63, FGF10, PAX3, PAX2, GLI2, GLI3, ZIC3, MAP3K7, BDNF, CD44, CTGF, 481 220 13528 8.181743 1.94E-36 8.09E-38 9.25E-37
CXCR4, ILK, GATA4, CASP8, MKKS, NOS3, HHIP, RARB, FGF2, RET, MMP14, HES1, PTHLH,
HHEX, EYA1, EP300, PSEN1, PSEN2, VEGFA, SIX1, FOXC2, TFAP2A, FOXC1, MED1, ACVR1,
WNT5A
GO:0007389~pattern specification process 1.40E-39 NOG, FOXA2, FST, PAX6, TP63, FGF10, ZEB1, GLI2, GLI3, ZIC3, CITED2, CXCR4, PAX7, GATA4, 481 267 13528 7.268191 5.44E-36 2.17E-37 2.59E-36
MKKS, HHIP, PITX2, EGR2, GSC, EFNB1, DLL3, LEF1, HES1, CTNNBIP1, ACVR2A, HHEX, EYA1,
CRKL, EP300, PSEN1, HIPK1, HOXC13, HIPK2, PSEN2, FOXG1, VEGFA, SIX1, MNX1, ROR2, F
GO:0010033~response to organic 1.45E-36 STAT5A, SLC6A3, PTGS1, SNCA, STAT5B, TGFB3, TLR4, AQP1, TGFB1, TGFB2, MYD88, CD44, 481 721 13528 4.095836 5.62E-33 2.16E-34 2.68E-33 substance APOE, GATA3, RARA, PRKACA, FAS, INSR, CCNA2, EGFR, RXRA, SOCS1, IRS1, MAPK1, THBD,
EP300, JUN, HSPB2, COL1A1, EIF2AK3, CAV1, ERBB4, GRB2, ERBB3, DRD2, ERBB2, SRF, SRC,
INS,
GO:0042325~regulation of 8.55E-36 CCNT1, TGFB3, TLR4, DAXX, PDCD4, PTEN, TGFB1, LATS2, TGFB2, AKT1, MAP3K7, MEN1, 481 466 13528 5.069696 3.32E-32 1.23E-33 1.58E-32 phosphorylation EDNRB, PDPK1, NOD2, CDKN2A, CDKN2C, APOE, CXCR4, CDKN2D, ILK, TGFA, PRKACA,
NRG1, INSR, FGF2, GHR, SYK, EGFR, GTPBP4, LYN, RBL2, RBL1, SOCS1, RB1, PRKCD, IRS1,
ACVR2A, CCND1,
GO:0048598~embryonic morphogenesis 1.97E-35 NOG, FOXA2, TGFB3, TP63, FGF10, PAX3, ZEB1, GLI2, PAX2, GLI3, MAP3K7, MEN1, GATA4, 481 307 13528 6.321196 7.66E-32 2.74E-33 3.65E-32
CASP8, MKKS, PRKACA, RARB, MYC, RET, MYO6, GSC, RARG, TP53, LEF1, HES1, ACVR2A,
EYA1, PSEN1, PSEN2, FOXG1, SIX1, ROR2, TFAP2A, FOXC2, FOXC1, MED1, ACVR1, WNT5A,
BBS4, COL2A
GO:0051174~regulation of phosphorus 2.72E-35 CCNT1, TGFB3, TLR4, DAXX, PDCD4, PTEN, TGFB1, LATS2, TGFB2, AKT1, MAP3K7, MEN1, 481 485 13528 4.929078 1.06E-31 3.65E-33 5.04E-32 metabolic process EDNRB, PDPK1, NOD2, CDKN2A, CDKN2C, APOE, CXCR4, CDKN2D, ILK, TGFA, PRKACA,
NRG1, INSR, FGF2, GHR, SYK, EGFR, GTPBP4, LYN, RBL2, RBL1, SOCS1, RB1, PRKCD, IRS1,
ACVR2A, CCND1,
GO:0019220~regulation of phosphate 2.72E-35 CCNT1, TGFB3, TLR4, DAXX, PDCD4, PTEN, TGFB1, LATS2, TGFB2, AKT1, MAP3K7, MEN1, 481 485 13528 4.929078 1.06E-31 3.65E-33 5.04E-32 metabolic process EDNRB, PDPK1, NOD2, CDKN2A, CDKN2C, APOE, CXCR4, CDKN2D, ILK, TGFA, PRKACA,
NRG1, INSR, FGF2, GHR, SYK, EGFR, GTPBP4, LYN, RBL2, RBL1, SOCS1, RB1, PRKCD, IRS1,
ACVR2A, CCND1,
GO:0007167~enzyme linked receptor 4.80E-35 NOG, STAT5A, STAT5B, FST, TGFB3, FGF10, PTEN, TGFB1, TGFB2, AKT1, MAP3K7, ACVR1B, 481 342 13528 5.920998 1.87E-31 6.22E-33 8.89E-32 protein signaling pathway FOS, CTGF, NRG1, INSR, FGF2, AKT2, SYK, GHR, EGFR, RET, IRS1, ACVR2A, ARRB2, JUN,
HIPK2, VEGFA, ROR2, ADAM17, FOXC2, PDGFRB, FOXC1, EIF2AK3, ACVR1, LCP2, FGFR2,
FGFR1, ERBB4
GO:0051252~regulation of RNA 7.36E-35 MEF2C, THRB, STAT5A, FST, STAT5B, TGFB3, CASK, TBP, CBFB, TGFB1, ZIC3, CITED2, GATA1, 481 1813 13528 2.621666 2.86E-31 9.23E-33 1.36E-31 metabolic process FLI1, CDKN2A, GATA3, GATA4, RARA, RARB, MLL4, INSR, TWIST2, PITX1, PITX2, IKBKAP,
RARG, MYO6, RXRA, RBL1, PPARGC1A, HES1, HHEX, EP300, HES5, JUN, SIX1, VEGFA, FOXG1,
MNX
GO:0051726~regulation of cell cycle 3.55E-34 E2F1, XPO1, NBN, MAEA, STAT5A, STAT5B, CCNT1, PDCD4, PTEN, LATS2, TGFB1, TGFB2, 481 331 13528 5.94783 1.38E-30 4.31E-32 6.57E-31
CITED2, CSNK2A2, AKT1, MEN1, CDKN2A, CDKN2C, CDKN2D, TGFA, H2AFX, INSR, CCNA2,
MYC, DLG1, EGFR, CDC7, CDK1, GTPBP4, TP53, CDK6, RB1, CDK2, PRKCQ, CCND1, JUN, FOXG1, ADAM17, FO
GO:0016310~phosphorylation 6.10E-34 STAT5A, SNCA, TGFB3, CASK, TGFB1, BTK, TGFB2, CSNK2A2, MAP3K7, CSNK2A1, COL4A3BP, 481 800 13528 3.761684 2.37E-30 7.18E-32 1.13E-30
ILK, PRKACA, INSR, MAP2K7, SYK, EGFR, IKBKAP, RET, STK4, MAPK1, CAMK4, RIPK3,
PDGFRB, ROR2, MAPK9, MAPK8, MAPK7, EIF2AK3, FGFR2, FGFR1, ERBB4, STK11, ERBB3,
ERBB2, NEK1, HUS
GO:0010942~positive regulation of cell 8.05E-34 MMP9, TGFB3, TP63, FASLG, TLR4, DAXX, PTEN, TGFB1, BTK, TGFB2, AKT1, MEN1, ACVR1B, 481 435 13528 5.107711 3.13E-30 9.21E-32 1.49E-30 death CDKN2A, HTRA2, CASP9, CD44, CDKN2C, APOE, CASP8, RARB, FAS, CASP2, MYC, TOP2A,
RARG, RXRA, TP53, MBD4, FADD, STK4, MAPK1, HIPK1, PSEN1, JUN, HIPK2, PSEN2, RIPK3,
MAPK9, MAP
GO:0006355~regulation of transcription, 8.53E-34 MEF2C, THRB, STAT5A, FST, STAT5B, TGFB3, CASK, TBP, CBFB, TGFB1, ZIC3, CITED2, GATA1, 481 1773 13528 2.617362 3.31E-30 9.47E-32 1.58E-30
DNA-dependent FLI1, CDKN2A, GATA3, GATA4, RARA, RARB, MLL4, INSR, TWIST2, PITX1, PITX2, IKBKAP,
RARG, MYO6, RXRA, RBL1, PPARGC1A, HES1, HHEX, EP300, HES5, JUN, SIX1, VEGFA, FOXG1,
MNX
GO:0001501~skeletal system development 2.12E-33 NOG, MMP9, TCOF1, TGFB3, TP63, ZEB1, GLI2, GLI3, CBFB, TGFB1, MEN1, CTGF, PAX7, MYC, 481 319 13528 5.995242 8.24E-30 2.29E-31 3.93E-30
PITX1, GHR, EGFR, GSC, DLL3, MMP14, PTHLH, ACVR2A, EYA1, PSEN1, SIX1, ROR2, TFAP2A,
FOXC2, PDGFRB, FOXC1, MAPK8, COL1A1, EIF2AK3, WNT5A, FGFR1, ACHE, PTH1R, COL2A1,
SOX9,
GO:0043065~positive regulation of 2.43E-33 MMP9, TGFB3, TP63, FASLG, TLR4, DAXX, PTEN, TGFB1, BTK, TGFB2, AKT1, MEN1, ACVR1B, 481 430 13528 5.101697 9.43E-30 2.55E-31 4.50E-30 apoptosis CDKN2A, HTRA2, CASP9, CD44, CDKN2C, APOE, CASP8, RARB, FAS, CASP2, MYC, TOP2A,
RARG, RXRA, TP53, MBD4, FADD, STK4, MAPK1, HIPK1, PSEN1, JUN, HIPK2, PSEN2, RIPK3,
MAPK9, MAP
GO:0043068~positive regulation of 3.98E-33 MMP9, TGFB3, TP63, FASLG, TLR4, DAXX, PTEN, TGFB1, BTK, TGFB2, AKT1, MEN1, ACVR1B, 481 433 13528 5.06635 1.55E-29 4.07E-31 7.38E-30 programmed cell death CDKN2A, HTRA2, CASP9, CD44, CDKN2C, APOE, CASP8, RARB, FAS, CASP2, MYC, TOP2A,
RARG, RXRA, TP53, MBD4, FADD, STK4, MAPK1, HIPK1, PSEN1, JUN, HIPK2, PSEN2, RIPK3,
MAPK9, MAP
GO:0043009~chordate embryonic 2.30E-32 NOG, NBN, FOXA2, PAX6, TGFB3, PAX3, ZEB1, GLI2, GLI3, CITED2, MAP3K7, MEN1, ACVR1B, 481 331 13528 5.777892 8.95E-29 2.29E-30 4.26E-29 development HSF1, PAX7, COL4A3BP, GATA4, CASP8, AR, GSC, DLL3, TP53, LEF1, HES1, ACVR2A, EYA1,
EP300, PSEN1, PSEN2, SIX1, MNX1, ROR2, TFAP2A, FOXC2, PDGFRB, FOXC1, COL1A1, MED1,
ACVR1
GO:0009792~embryonic development 4.11E-32 NOG, NBN, FOXA2, PAX6, TGFB3, PAX3, ZEB1, GLI2, GLI3, CITED2, MAP3K7, MEN1, ACVR1B, 481 334 13528 5.725995 1.60E-28 3.99E-30 7.61E-29 ending in birth or egg hatching HSF1, PAX7, COL4A3BP, GATA4, CASP8, AR, GSC, DLL3, TP53, LEF1, HES1, ACVR2A, EYA1,
EP300, PSEN1, PSEN2, SIX1, MNX1, ROR2, TFAP2A, FOXC2, PDGFRB, FOXC1, COL1A1, MED1,
ACVR1
GO:0045596~negative regulation of cell 4.60E-32 NOG, NBN, FOXA2, STAT5A, STAT5B, PPARG, FST, PAX6, TP63, FGF10, TLR4, ZEB1, GLI2, GLI3, 481 216 13528 7.291599 1.79E-28 4.36E-30 8.52E-29 differentiation TGFB1, MEN1, BDNF, TWIST2, TP53, DLL3, CDK6, PTHLH, HES1, MAPK1, CCND1, HES5, PSEN1,
FOXG1, NGFR, CAV1, TCL1A, ITGB3, ABCA1, KIT, SOX9, EPHB2, NR1H2, PTK2, HOXA2, GFI1
GO:0008285~negative regulation of cell 1.08E-31 NOG, PPARG, PAX6, TGFB3, FGF10, ZEB1, PTEN, GLI3, TGFB1, TGFB2, MEN1, BDNF, CDKN2A, 481 361 13528 5.453551 4.19E-28 9.97E-30 2.00E-28 proliferation HSF1, CDKN2C, APOE, CDKN2D, ILK, NOS3, RARB, CSK, FGF2, GTPBP4, RARG, RXRA, TP53,
CDK6, RB1, ESR2, PTHLH, JUN, CAV1, TNF, DRD2, STK11, ERBB2, PTH1R, SFN, ALDH1A2, VDR,
BCL
GO:0045449~regulation of transcription 1.68E-31 MEF2C, STAT5A, FST, STAT5B, CITED2, FLI1, MYD88, RARA, RARB, CCNA2, TWIST2, PITX1, 481 2601 13528 2.184236 6.51E-28 1.51E-29 3.10E-28
PITX2, IKBKAP, RARG, RXRA, PPARGC1A, HES1, MAPK1, HES5, JUN, FOXG1, VEGFA, NR1H2,
TAL1, INS, LHX3, NKX2-1, NKX2-5, HIP1, BMP4, KLF5, BMP2, MLL, SMAD5, CREBBP, SMAD4,
SMAD3,
GO:0007242~intracellular signaling 2.08E-31 HRAS, STAT5A, STAT5B, TGFB3, TLR4, BTK, MAP3K7, CTGF, APOE, H2AFX, RARA, PRKACA, 481 1256 13528 2.955785 8.10E-28 1.84E-29 3.86E-28 cascade INSR, MAP2K7, CCNA2, SYK, EGFR, IKBKAP, RET, RARG, MYO6, RXRA, SOCS1, PPARGC1A,
IRS1, STK4, PTHLH, MAPK1, CD36, RIPK3, MAPK9, ROR2, MAPK8, MAPK7, EIF2AK3, WNT5A,
FGFR1, CAV1,
GO:0048534~hemopoietic or lymphoid 2.18E-31 XRCC5, MAEA, STAT5A, MMP9, STAT5B, PPARG, FGF10, CBFB, TGFB1, TGFB2, MEN1, CASP8, 481 260 13528 6.490325 8.47E-28 1.88E-29 4.04E-28 organ development FAS, CHUK, SYK, EGR1, LYN, TP53, CDK6, RB1, CRKL, PSEN1, PSEN2, VEGFA, SIX1, ADAM17,
TSHR, MED1, TNF, BLM, CSF1, RAG1, KITLG, SOX4, PRKDC, KIT, RAG2, ADA, TAL1, CHD7,
BCL2, GO:0006796~phosphate metabolic process 5.98E-31 STAT5A, SNCA, TGFB3, CASK, TGFB1, BTK, TGFB2, CSNK2A2, MAP3K7, CSNK2A1, COL4A3BP, 481 973 13528 3.295191 2.33E-27 5.06E-29 1.11E-27
ILK, PRKACA, INSR, MAP2K7, SYK, EGFR, IKBKAP, RET, STK4, MAPK1, CAMK4, RIPK3,
PDGFRB, ROR2, MAPK9, MAPK8, MAPK7, EIF2AK3, FGFR2, FGFR1, ERBB4, STK11, ERBB3,
NEK1, ERBB2, HUS
GO:0006793~phosphorus metabolic 5.98E-31 STAT5A, SNCA, TGFB3, CASK, TGFB1, BTK, TGFB2, CSNK2A2, MAP3K7, CSNK2A1, COL4A3BP, 481 973 13528 3.295191 2.33E-27 5.06E-29 1.11E-27 process ILK, PRKACA, INSR, MAP2K7, SYK, EGFR, IKBKAP, RET, STK4, MAPK1, CAMK4, RIPK3,
PDGFRB, ROR2, MAPK9, MAPK8, MAPK7, EIF2AK3, FGFR2, FGFR1, ERBB4, STK11, ERBB3,
NEK1, ERBB2, HUS
GO:0002520~immune system 8.19E-31 XRCC5, NBN, MAEA, STAT5A, MMP9, STAT5B, PPARG, FGF10, CBFB, TGFB1, TGFB2, MEN1, 481 276 13528 6.215975 3.18E-27 6.77E-29 1.52E-27 development CASP8, FAS, CHUK, SYK, EGR1, LYN, TP53, CDK6, RB1, CRKL, PSEN1, PSEN2, VEGFA, SIX1,
ADAM17, TSHR, MED1, TNF, BLM, CSF1, RAG1, KITLG, SOX4, PRKDC, KIT, RAG2, ADA, TAL1,
CHD7, B
GO:0048732~gland development 8.29E-31 NOG, CAV1, ERBB4, ELF3, DRD2, ERBB3, STAT5A, SLC6A3, ERBB2, STAT5B, PAX6, TGFB3, 481 135 13528 9.374913 3.22E-27 6.71E-29 1.54E-27
TP63, FGF10, GLI2, GLI3, TGFB1, TGFB2, CITED2, IGF1R, ALDH1A2, BCL2, PAX8, NKX2-1, NRG1,
NKX2-5, PITX1, BMP4, EGFR, AR, MET, LEF1, IGF1, BRCA2, IRS1, HES1, PTHLH, HHEX, EYA1,
GO:0030097~hemopoiesis 6.29E-30 XRCC5, MAEA, STAT5A, MMP9, STAT5B, PPARG, CBFB, TGFB1, TGFB2, MEN1, CASP8, FAS, 481 236 13528 6.673667 2.45E-26 4.99E-28 1.17E-26
CHUK, SYK, EGR1, LYN, TP53, CDK6, RB1, PSEN1, VEGFA, PSEN2, ADAM17, TSHR, MED1, TNF,
BLM, CSF1, RAG1, KITLG, SOX4, PRKDC, KIT, RAG2, ADA, TAL1, CHD7, BCL2, ZAP70, RUNX1,
NKX2-
GO:0007423~sensory organ development 1.14E-29 NOG, PAX6, TGFB3, FASLG, FGF10, ZEB1, PAX2, GLI3, TGFB1, TGFB2, BDNF, RARB, MYC, 481 229 13528 6.75485 4.43E-26 8.86E-28 2.11E-26
EGFR, MYO6, GSC, RARG, HES1, EYA1, HES5, HOXC13, FOXG1, VEGFA, SIX1, FOXC2, FOXC1,
MED1, BBS4, ERBB3, ERBB2, COL2A1, WT1, EPHB2, HOXA1, ALDH1A2, HOXA2, CHD7, BCL2,
GBX2, POU2
GO:0009719~response to endogenous 2.58E-29 STAT5A, LEPR, PPARG, STAT5B, PTGS1, TGFB3, AQP1, PTEN, TGFB1, LATS2, TGFB2, AKT1, 481 405 13528 4.93051 1.00E-25 1.97E-27 4.78E-26 stimulus FOS, CCNE1, PDPK1, GATA3, RARA, PRKACA, NOS3, FAS, INSR, CCNA2, AKT2, GHR, AR, EGR2,
LYN, RXRA, SOCS1, ESR1, ESR2, MMP14, IRS1, MAPK1, PRKCQ, CCND1, EP300, ADAM17, FOXC2, CO
GO:0003002~regionalization 3.93E-28 NOG, FOXA2, PAX6, TP63, GLI2, GLI3, ZIC3, PAX7, GATA4, HHIP, GSC, EGR2, DLL3, LEF1, HES1, 481 197 13528 7.138259 1.53E-24 2.94E-26 7.28E-25
CTNNBIP1, ACVR2A, HHEX, CRKL, EP300, PSEN1, HIPK1, HOXC13, FOXG1, PSEN2, HIPK2,
MNX1, ROR2, PRKDC, HOXA1, ALDH1A2, HOXA2, GBX2, NKX2-1, APC, BMP4, MLL, MAFB,
HTT, MY
GO:0010605~negative regulation of 4.02E-28 E2F1, MEF2C, THRB, PPARG, SNCA, FST, TGFB3, SPI1, TP63, NFKB1, ZEB1, PAX3, GLI2, PAX2, 481 734 13528 3.601806 1.56E-24 2.94E-26 7.44E-25 macromolecule metabolic process DAXX, PDCD4, GLI3, TGFB1, CITED2, MEN1, CDKN2A, RARB, NRG1, INSR, FGF2, MYC, TWIST2,
EGR1, GTPBP4, GSC, RARG, RXRA, RBL1, SOCS1, TP53, LEF1, RB1, PRKCD, CTNNBIP1, HES1,
GO:0008283~cell proliferation 4.52E-28 XRCC5, E2F1, NBN, FST, TP63, FGF10, ZEB1, GLI2, FES, PTEN, TGFB1, TGFB2, DKC1, CXCR4, 481 436 13528 4.644452 1.76E-24 3.25E-26 8.38E-25
COL4A3BP, ILK, TGFA, HHIP, NRG1, MYC, OCA2, SYK, DLG1, EGFR, AR, CCKBR, RXRA, SOX11,
TPX2, TP53, CDK9, MMP14, PRKCD, CTNNBIP1, ACVR2A, HHEX, PSEN1, VEGFA, FOXC2,
FOXC1,
GO:0009725~response to hormone 7.22E-28 STAT5A, LEPR, PPARG, STAT5B, PTGS1, TGFB3, AQP1, PTEN, TGFB1, LATS2, TGFB2, AKT1, 481 367 13528 5.057855 2.80E-24 5.10E-26 1.34E-24 stimulus FOS, CCNE1, PDPK1, GATA3, RARA, PRKACA, NOS3, FAS, INSR, CCNA2, AKT2, GHR, AR, EGR2,
LYN, RXRA, SOCS1, ESR1, ESR2, MMP14, IRS1, MAPK1, PRKCQ, CCND1, EP300, FOXC2,
COL1A1, CA
GO:0043549~regulation of kinase activity 9.37E-28 CCNT1, TGFB3, DAXX, PDCD4, PTEN, TGFB1, LATS2, TGFB2, AKT1, MAP3K7, MEN1, PDPK1, 481 357 13528 5.120751 3.64E-24 6.50E-26 1.74E-24
CDKN2A, CDKN2C, APOE, CXCR4, CDKN2D, ILK, TGFA, PRKACA, NRG1, INSR, FGF2, SYK,
GHR, EGFR, GTPBP4, RBL2, RBL1, RB1, IRS1, CCND1, PSEN1, PSEN2, ADAM17, CAV1, TNF,
BLM, CSF1, ER
GO:0051338~regulation of transferase 1.62E-27 PPARG, CCNT1, TGFB3, DAXX, PDCD4, PTEN, TGFB1, LATS2, TGFB2, AKT1, MAP3K7, MEN1, 481 372 13528 4.989873 6.28E-24 1.10E-25 2.99E-24 activity PDPK1, CDKN2A, CDKN2C, APOE, CXCR4, CDKN2D, ILK, TGFA, PRKACA, NRG1, INSR, FGF2,
SYK, GHR, EGFR, GTPBP4, RBL2, RBL1, RB1, IRS1, CCND1, PSEN1, PSEN2, ADAM17, CAV1, TNF,
BLM, C
GO:0035239~tube morphogenesis 1.93E-27 BBS4, FOXA2, TP63, FGF10, PAX3, PAX2, GLI2, SRF, GLI3, ZIC3, MAP3K7, CD44, CXCR4, BCL2, 481 127 13528 9.079641 7.51E-24 1.29E-25 3.58E-24
ILK, CASP8, GATA4, GBX2, MKKS, NKX2-5, BMP4, BMP2, RET, TGFBR2, SMAD4, IGF1, MMP14, KDR, EYA1, NOTCH1, TSC1, PSEN1, VEGFA, SIX1, TSC2, FOXC2, TFAP2A, PBX1, APAF1, ENG,
GO:0007243~protein kinase cascade 7.63E-27 STAT5A, STAT5B, TGFB3, TLR4, DAXX, LATS2, BTK, MAP3K7, AKT1, MEN1, CXCR4, TGFA, 481 370 13528 4.940833 2.96E-23 5.02E-25 1.41E-23
PRKACA, MAP2K7, FGF2, INSR, CHUK, SYK, GHR, EGFR, IKBKAP, RET, SOCS1, STK4, IRS1,
TYK2, MAPK1, CRKL, PSEN1, RIPK3, ROR2, MAPK9, MAPK8, MAPK7, WNT5A, FGFR1, CAV1,
TNF, DRD2, GR
GO:0045165~cell fate commitment 7.65E-27 ERBB4, FOXA2, PPARG, PAX6, PRKDC, FGF10, RAG2, PAX3, PAX2, SOX9, GLI2, GLI3, TGFB2, 481 139 13528 8.498123 2.97E-23 4.95E-25 1.42E-23
MEN1, TAL1, HOXA2, BCL2, PAX7, POU2F1, NKX2-1, GFI1, RUNX2, FGF2, PITX1, BMP4, TBX6,
BMP2, SMAD5, TP53, SMAD4, SMAD2, SMAD1, KDR, HES1, EYA1, NOTCH1, HES5, PSEN1,
PSEN2, S
GO:0009967~positive regulation of signal 1.68E-26 HRAS, LEPR, TGFB3, TP63, FASLG, FGF10, TLR4, TGFB1, TGFB2, CITED2, MAP3K7, MEN1, 481 295 13528 5.52961 6.54E-23 1.07E-24 3.12E-23 transduction ACVR1B, NOD2, MYD88, ILK, CASP8, TGFA, INSR, SYK, GHR, LYN, ESR1, FADD, IRS1, ACVR2A,
HHEX, HIPK2, VEGFA, ADAM17, CAV1, TNF, ERBB3, CSF1, ERBB2, SOX4, KIT, ADA, SRC,
ARNT, TN
GO:0010647~positive regulation of cell 1.85E-26 HRAS, LEPR, SNCA, TGFB3, TP63, FASLG, FGF10, TLR4, TGFB1, TGFB2, CITED2, MAP3K7, 481 329 13528 5.214617 7.17E-23 1.16E-24 3.42E-23 communication MEN1, ACVR1B, NOD2, MYD88, ILK, CASP8, TGFA, INSR, SYK, GHR, EGFR, LYN, ESR1, FADD,
IRS1, ACVR2A, HHEX, HIPK2, VEGFA, ADAM17, CAV1, TNF, ERBB4, ERBB3, CSF1, ERBB2,
SOX4, KIT,
GO:0051240~positive regulation of 2.39E-26 STAT5A, IL18, SLC6A3, FST, STAT5B, SNCA, PTGS1, TGFB3, TLR4, TGFB1, TGFB2, MAP3K7, 481 244 13528 6.109062 9.29E-23 1.47E-24 4.43E-23 multicellular organismal process AKT1, NOD2, MYD88, HSF1, GATA4, RARA, NOS3, NRG1, FGF2, GHR, EGFR, ACVR2A, PSEN1,
PSEN2, ADAM17, TSHR, ACVR1, CAV1, TNF, ERBB4, DRD2, CSF1, SRF, ADA, ARNT, CHD7, INS,
BCL2,
GO:0009890~negative regulation of 2.96E-26 E2F1, MEF2C, THRB, PPARG, FST, SPI1, TGFB3, TP63, NFKB1, ZEB1, PAX3, GLI2, PAX2, DAXX, 481 573 13528 3.926665 1.15E-22 1.80E-24 5.48E-23 biosynthetic process PDCD4, GLI3, TGFB1, CITED2, MEN1, APOE, RARB, NRG1, FGF2, TWIST2, EGR1, GTPBP4, GSC,
RARG, RXRA, RBL1, TP53, LEF1, RB1, CTNNBIP1, HES1, HHEX, HES5, HIPK2, EIF2AK3, CAV1
GO:0045859~regulation of protein kinase 3.88E-26 CCNT1, TGFB3, DAXX, PDCD4, PTEN, LATS2, TGFB1, TGFB2, AKT1, MAP3K7, MEN1, PDPK1, 481 345 13528 5.054301 1.51E-22 2.32E-24 7.18E-23 activity CDKN2A, APOE, CXCR4, CDKN2C, CDKN2D, ILK, TGFA, PRKACA, NRG1, FGF2, INSR, SYK, GHR, EGFR, GTPBP4, RB1, CCND1, PSEN1, PSEN2, ADAM17, CAV1, TNF, BLM, CSF1, ERBB2,
MAP4K1, KITLG
GO:0048729~tissue morphogenesis 5.25E-26 BBS4, FST, TP63, PAX3, PAX2, GLI2, GLI3, TGFB2, MAP3K7, ALDH1A2, CD44, BCL2, ILK, CASP8, 481 180 13528 7.187434 2.04E-22 3.09E-24 9.73E-23
MKKS, PRKACA, NKX2-5, CHUK, RUNX3, BMP4, TBX6, BMP2, RET, NF2, HTT, RXRA, SMAD4,
SMAD3, LEF1, SMAD2, SMAD1, ATP7A, EYA1, NOTCH1, TSC1, SIX1, TSC2, FOXC2, TFAP2A,
PBX1
GO:0044093~positive regulation of 1.32E-25 TGFB3, TLR4, DAXX, TGFB1, TGFB2, AKT1, MAP3K7, MEN1, EDNRB, PDPK1, NOD2, CDKN2A, 481 586 13528 3.839555 5.13E-22 7.65E-24 2.44E-22 molecular function MYD88, CASP9, APOE, CXCR4, ILK, TGFA, PRKACA, NOS3, BRD4, NRG1, INSR, FGF2, MYC,
GHR, SYK, EGFR, CDK1, CCKBR, TP53, IRS1, PTHLH, PRKCQ, CCND1, EP300, PSEN1, HIPK2,
PSEN2, ADA
GO:0010558~negative regulation of 1.79E-25 E2F1, MEF2C, THRB, PPARG, FST, SPI1, TGFB3, TP63, NFKB1, ZEB1, PAX3, GLI2, PAX2, DAXX, 481 547 13528 3.959058 6.96E-22 1.02E-23 3.32E-22 macromolecule biosynthetic process PDCD4, GLI3, TGFB1, CITED2, MEN1, RARB, NRG1, FGF2, TWIST2, EGR1, GTPBP4, GSC, RARG,
RXRA, RBL1, TP53, LEF1, RB1, HES1, CTNNBIP1, HHEX, HES5, HIPK2, EIF2AK3, TNF, BLM,
GO:0031327~negative regulation of 1.83E-25 E2F1, MEF2C, THRB, PPARG, FST, SPI1, TGFB3, TP63, NFKB1, ZEB1, PAX3, GLI2, PAX2, DAXX, 481 561 13528 3.910392 7.13E-22 1.03E-23 3.40E-22 cellular biosynthetic process PDCD4, GLI3, TGFB1, CITED2, MEN1, RARB, NRG1, FGF2, TWIST2, EGR1, GTPBP4, GSC, RARG,
RXRA, RBL1, TP53, LEF1, RB1, CTNNBIP1, HES1, HHEX, HES5, HIPK2, EIF2AK3, CAV1, TNF,
GO:0032583~regulation of gene-specific 2.42E-25 MEF2C, TNF, FOXA2, PPARG, TGFB3, SPI1, PRKDC, NFKB1, SRF, CITED2, ARNT, NR1H2, VDR, 481 134 13528 8.395445 9.42E-22 1.35E-23 4.49E-22 transcription TAL1, INS, GATA4, GFI1, NKX2-5, INSR, BMP2, RXRA, TP53, SMAD3, IGF1, IGF2, SMAD2, ESR2,
FOXP3, SIRT1, PPARGC1A, HES1, CDKN1C, HDAC4, HHEX, NOTCH1, CDKN1B, HES5, ETS1,
NR5A
GO:0048568~embryonic organ 6.82E-25 NOG, TGFB3, FGF10, COL2A1, ZEB1, PAX2, GLI2, GLI3, ADA, CITED2, ARNT, MEN1, HOXA1, 481 172 13528 7.194701 2.65E-21 3.74E-23 1.26E-21 development ALDH1A2, HOXA2, CHD7, HSF1, GATA4, NKX3-2, GBX2, GFI1, RARB, MYC, RARG, MYO6, GSC,
CEBPB, MLL, MAFB, MYF5, TGFBR2, HOXB1, EYA1, DLX6, DLX5, VEGFA, FOXG1, SIX1,
FOXC2, ROR2,
GO:0003006~reproductive developmental 8.28E-25 NOG, STAT5A, LEPR, FST, STAT5B, TGFB3, TP63, TGFB2, CITED2, AKT1, CCNE1, CXCR4, MKKS, 481 262 13528 5.689356 3.22E-21 4.47E-23 1.53E-21 process NOS3, FANCA, INSR, OCA2, AR, MMP14, ACVR2A, CCND1, VEGFA, ROR2, FOXC1, ACVR1, BBS4, CSF1, PRKDC, KIT, SOX9, WT1, IGF1R, VDR, CHD7, BCL2, NKX2-1, FBXO5, PAFAH1B1,
AXIN1,
GO:0051270~regulation of cell motion 1.22E-24 BBS4, ERBB4, DRD2, MMP9, CSF1, STAT5B, PAX6, ITGB3, KIT, PTEN, TGFB1, ADA, CITED2, 481 193 13528 6.703306 4.76E-21 6.52E-23 2.27E-21
VCL, TGFB2, AKT1, IGF1R, CXCR4, INS, APOE, BCL2, ILK, MKKS, FGF2, INSR, APC, EGFR, SELP,
GTPBP4, LYN, NF2, SPHK1, SMAD3, IGF1, IGF2, IRS1, KDR, MAPK1, CDKN1B, ETS1, VEGFA,
GO:0040012~regulation of locomotion 8.74E-24 BBS4, ERBB4, DRD2, MMP9, CSF1, SNCA, PAX6, FGF10, ITGB3, KIT, PTEN, TGFB1, ADA, 481 192 13528 6.591736 3.40E-20 4.59E-22 1.62E-20
CITED2, VCL, TGFB2, AKT1, IGF1R, CXCR4, INS, APOE, BCL2, ILK, MKKS, FGF2, INSR, APC,
EGFR, SELP, GTPBP4, NF2, SPHK1, SMAD3, IGF1, IGF2, IRS1, KDR, MAPK1, VEGFA, ADAM17,
PDGFRB
GO:0007507~heart development 1.76E-23 BBS4, ERBB4, ERBB3, ERBB2, PRKDC, SOX4, COL2A1, PAX3, SOX9, GLI2, SRF, GLI3, PTEN, 481 215 13528 6.148199 6.83E-20 9.11E-22 3.25E-20
ZIC3, TGFB2, CITED2, ALDH1A2, CHD7, COL4A3BP, GATA4, CASP8, MKKS, NFATC4, RARB,
NRG1, NFATC3, NKX2-5, INSR, BMP4, BMP2, RXRA, TGFBR2, SMAD2, HHEX, NOTCH1, CRKL,
EP300, PSEN
GO:0051172~negative regulation of 2.09E-23 E2F1, MEF2C, THRB, PPARG, FST, SPI1, TGFB3, TP63, NFKB1, ZEB1, PAX3, GLI2, PAX2, DAXX, 481 519 13528 3.901698 8.14E-20 1.07E-21 3.88E-20 nitrogen compound metabolic process PDCD4, GLI3, TGFB1, CITED2, MEN1, RARB, NRG1, FGF2, TWIST2, EGR1, GTPBP4, GSC, RARG,
RXRA, RBL1, TP53, LEF1, RB1, HES1, CTNNBIP1, HHEX, HES5, HIPK2, CAV1, TNF, BLM, HUS
GO:0006916~anti-apoptosis 2.19E-23 MEF2C, TNF, STAT5A, STAT5B, SNCA, TP63, NFKB1, CITED2, AKT1, IGF1R, BDNF, MYD88, 481 206 13528 6.280282 8.51E-20 1.11E-21 4.06E-20
APOE, CDKN2D, BCL2, PAX7, NOS3, AATF, FAS, NRG1, MKL1, MYC, NKX2-5, CASP2, TWIST2,
TERT, HELLS, CDK1, CEBPB, HTT, SPHK1, ESR1, IGF1, BIRC5, ESR2, PRLR, PSEN1, BAX,
VEGFA, FOX
GO:0031399~regulation of protein 3.92E-23 SNCA, TGFB3, TLR4, DAXX, PDCD4, TGFB1, MEN1, EDNRB, NOD2, CDKN2A, FGF2, INSR, SYK, 481 295 13528 5.148258 1.52E-19 1.95E-21 7.26E-20 modification process GHR, EGFR, CDK1, GTPBP4, LYN, SOCS1, PRKCD, PPARGC1A, ACVR2A, CCND1, PSEN1, JUN,
PSEN2, ADAM17, PDGFRB, CAV1, TNF, KITLG, MAP4K1, INS, BCL2, FBXO5, AXIN1, BMP4,
PTPRC, BMP2
GO:0045934~negative regulation of 4.59E-23 E2F1, MEF2C, THRB, PPARG, FST, SPI1, TGFB3, TP63, NFKB1, ZEB1, PAX3, GLI2, PAX2, DAXX, 481 512 13528 3.90011 1.78E-19 2.26E-21 8.50E-20 nucleobase, nucleoside, nucleotide and PDCD4, GLI3, TGFB1, CITED2, MEN1, RARB, NRG1, FGF2, TWIST2, EGR1, GTPBP4, GSC, RARG, nucleic acid metabolic process RXRA, RBL1, TP53, LEF1, RB1, HES1, CTNNBIP1, HHEX, HES5, HIPK2, TNF, BLM, HUS1, SOX
GO:0001932~regulation of protein amino 7.96E-23 CAV1, TNF, TGFB3, KITLG, MAP4K1, TLR4, DAXX, PDCD4, TGFB1, MEN1, EDNRB, NOD2, INS, 481 173 13528 6.827972 3.09E-19 3.87E-21 1.47E-19 acid phosphorylation BCL2, FGF2, INSR, AXIN1, GHR, SYK, BMP4, EGFR, PTPRC, BMP2, LYN, NF2, SOCS1, SMAD4,
IGF1, IGF2, PRKCD, TP73, ACVR2A, CCND1, PSEN1, JUN, BAX, PSEN2, PDGFRB, ADAM17, JAK2,
MT
GO:0060284~regulation of cell 1.46E-22 XRCC5, NOG, NBN, FOXA2, DRD2, PPARG, PAX6, TGFB3, KIT, GLI2, TGFB1, TGFB2, EPHB2, 481 205 13528 6.173723 5.68E-19 7.02E-21 2.71E-19 development HOXA2, BDNF, PTK2, INS, APOE, BCL2, ILK, NKX2-5, FGF2, SPP1, BMP4, BMP2, LYN, GRIN1,
DLL3, TP53, SMAD4, SMAD3, IGF2, SMAD2, SMAD1, HES1, HDAC4, EYA1, NOTCH1, HES5,
PSEN1, BA
GO:0032268~regulation of cellular protein 3.27E-22 SNCA, TGFB3, NFKB1, TLR4, DAXX, PDCD4, TGFB1, AKT1, MEN1, EDNRB, NOD2, CDKN2A, 481 474 13528 3.975438 1.27E-18 1.55E-20 6.07E-19 metabolic process APOE, QKI, INSR, FGF2, SYK, GHR, EGFR, CDK1, GTPBP4, LYN, SOCS1, PPARGC1A, PRKCD,
MAPK1, ACVR2A, CCND1, EP300, PSEN1, JUN, PSEN2, ADAM17, PDGFRB, EIF2AK3, CAV1, TNF,
CSF1, MAP4
GO:0010629~negative regulation of gene 4.34E-22 E2F1, MEF2C, THRB, FST, PPARG, SPI1, TP63, NFKB1, ZEB1, PAX3, GLI2, PAX2, DAXX, PDCD4, 481 504 13528 3.850411 1.69E-18 2.03E-20 8.04E-19 expression GLI3, TGFB1, CITED2, MEN1, RARB, NRG1, INSR, FGF2, MYC, TWIST2, EGR1, GSC, RARG,
RXRA, RBL1, TP53, LEF1, RB1, HES1, CTNNBIP1, HHEX, HES5, HIPK2, TNF, SOX9, WT1, NR1H2,
GO:0048545~response to steroid hormone 6.43E-22 CAV1, TNF, ERBB4, LEPR, ERBB2, STAT5B, PTGS1, PPARG, TGFB3, AQP1, PTEN, SRC, TGFB1, 481 192 13528 6.29877 2.50E-18 2.97E-20 1.19E-18 stimulus TGFB2, CCNE1, ALDH1A2, FOS, GATA3, BCL2, NOS3, RARA, FAS, NKX2-5, CCNA2, INSR, SPP1,
GHR, BMP4, RXRA, SOCS1, TGFBR2, ESR1, BRCA2, ESR2, MMP14, BRCA1, STAT3, MAPK1,
PLA2G4A
GO:0050678~regulation of epithelial cell 2.25E-21 NOG, ERBB4, ERBB2, PAX6, FGF10, TGFB1, TGFB2, EDNRB, TGFA, FGF2, RUNX3, APC, EGFR, 481 71 13528 11.09145 8.76E-18 1.03E-19 4.17E-18 proliferation SMAD3, BRCA2, IGF1, CDK6, ESR2, FOXP2, KDR, CDKN1C, NOTCH1, CDKN1B, DLX6, DLX5,
BAX, TSC2, VEGFA
GO:0030334~regulation of cell migration 2.57E-21 ERBB4, DRD2, MMP9, CSF1, PAX6, ITGB3, KIT, PTEN, ADA, TGFB1, CITED2, VCL, TGFB2, AKT1, 481 169 13528 6.656743 9.97E-18 1.16E-19 4.75E-18
IGF1R, CXCR4, INS, APOE, BCL2, ILK, FGF2, INSR, APC, EGFR, SELP, GTPBP4, NF2, SPHK1,
SMAD3, IGF1, IGF2, IRS1, KDR, MAPK1, VEGFA, ADAM17, PDGFRB, JAK2, CHRD, HDAC6, F2R GO:0001568~blood vessel development 5.22E-21 CAV1, LEPR, IL18, FGF10, SRF, PTEN, WT1, TGFB2, CITED2, MAP3K7, AKT1, PTK2, CHD7, CD44, 481 245 13528 5.395358 2.03E-17 2.33E-19 9.67E-18
CXCR4, CTGF, APOE, CASP8, GBX2, TGFA, QKI, NOS3, NKX2-5, FGF2, RASA1, BMP4, KLF5,
SELP, TGFBR2, MMP14, KDR, ATP7A, NOTCH1, CRKL, PSEN1, MEOX2, ID1, MAPK14, JUN, BAX,
V
GO:0001655~urogenital system 5.46E-21 NOG, TP63, PAX2, GLI2, GLI3, WT1, ALDH1A2, BDNF, CD44, BCL2, PAX8, ILK, RARB, HELLS, 481 110 13528 8.437422 2.12E-17 2.41E-19 1.01E-17 development APC, BMP4, BMP2, AR, RET, SOX11, SMAD4, LEF1, SMAD1, EYA1, TSC1, BAX, SIX1, GDF11,
PDGFRB, FOXC2, PBX1, FOXC1, ACVR1
GO:0016481~negative regulation of 6.77E-21 E2F1, MEF2C, THRB, FST, PPARG, SPI1, TP63, NFKB1, PAX3, ZEB1, GLI2, PAX2, DAXX, PDCD4, 481 459 13528 3.921532 2.63E-17 2.96E-19 1.25E-17 transcription GLI3, TGFB1, CITED2, MEN1, RARB, NRG1, FGF2, TWIST2, EGR1, GSC, RARG, RXRA, RBL1,
TP53, LEF1, RB1, HES1, CTNNBIP1, HHEX, HES5, HIPK2, TNF, SOX9, WT1, NR1H2, VDR, HOXA2,
GO:0040008~regulation of growth 6.79E-21 NOG, STAT5A, SLC6A3, STAT5B, PPARG, TP63, TGFB1, TGFB2, MEN1, AKT1, ACVR1B, 481 341 13528 4.536248 2.64E-17 2.93E-19 1.26E-17
CDKN2A, CD44, HSF1, HTRA2, CTGF, APOE, CDKN2C, CDKN2D, ILK, GATA4, NRG1, FGF2,
INSR, GHR, SOCS1, TP53, RB1, ESR2, PRKCQ, EP300, FOXC2, ADAM17, FOXC1, TSHR, DRD2,
FOXM1, CSF1, RAG2
GO:0006928~cell motion 8.67E-21 PAX6, IL13, CXCR3, PAX3, GLI2, PTEN, TGFB1, TGFB2, VCL, EDNRB, BDNF, GAB2, CD44, CTGF, 481 475 13528 3.848649 3.37E-17 3.70E-19 1.61E-17
CXCR4, NOS3, FGF2, SYK, RET, EGR2, EFNB1, ESR2, MMP14, PSEN1, FOXG1, SIX1, ADAM17,
PDGFRB, FOXC1, EFNA5, MAPK8, NGFR, WASL, ACVR1, TNF, DRD2, ERBB2, KITLG, PRKDC,
KIT,
GO:0045892~negative regulation of 9.48E-21 MEF2C, E2F1, FST, PPARG, SPI1, TP63, NFKB1, PAX3, ZEB1, PAX2, GLI2, DAXX, CITED2, MEN1, 481 356 13528 4.424116 3.68E-17 4.00E-19 1.76E-17 transcription, DNA-dependent RARB, FGF2, TWIST2, EGR1, RARG, GSC, RXRA, RBL1, TP53, LEF1, RB1, HES1, CTNNBIP1,
HHEX, HES5, HIPK2, TNF, SOX9, WT1, VDR, HOXA2, POU2F1, NKX2-1, GFI1, NKX2-5, HELLS, B
GO:0006917~induction of apoptosis 1.15E-20 TGFB3, FASLG, TP63, PTEN, DAXX, TGFB1, BTK, ACVR1B, CDKN2A, HTRA2, APOE, CDKN2C, 481 320 13528 4.65816 4.46E-17 4.79E-19 2.12E-17
CASP8, FAS, MYC, CASP2, TP53, FADD, MBD4, MAPK1, PSEN1, HIPK1, HIPK2, PSEN2, RIPK3,
MAPK9, MAPK8, NGFR, BID, TNF, AKAP13, SFN, GCH1, VDR, SOS1, AATF, RUNX3, HIP1,
ERCC2, CEBP
GO:0043085~positive regulation of 1.16E-20 TGFB3, DAXX, TGFB1, TGFB2, AKT1, MAP3K7, MEN1, EDNRB, PDPK1, CDKN2A, CASP9, APOE, 481 520 13528 3.677851 4.50E-17 4.79E-19 2.15E-17 catalytic activity CXCR4, ILK, TGFA, PRKACA, NOS3, NRG1, INSR, FGF2, MYC, SYK, GHR, EGFR, CDK1, CCKBR,
TP53, IRS1, PTHLH, CCND1, PSEN1, PSEN2, ADAM17, TSHR, EIF2AK3, CAV1, TNF, DRD2, CSF1,
ERB
GO:0012502~induction of programmed 1.32E-20 TGFB3, FASLG, TP63, PTEN, DAXX, TGFB1, BTK, ACVR1B, CDKN2A, HTRA2, APOE, CDKN2C, 481 321 13528 4.643649 5.15E-17 5.42E-19 2.45E-17 cell death CASP8, FAS, MYC, CASP2, TP53, FADD, MBD4, MAPK1, PSEN1, HIPK1, HIPK2, PSEN2, RIPK3,
MAPK9, MAPK8, NGFR, BID, TNF, AKAP13, SFN, GCH1, VDR, SOS1, AATF, RUNX3, HIP1,
ERCC2, CEBP
GO:0030182~neuron differentiation 1.41E-20 FOXA2, PAX6, PAX3, GLI2, PAX2, PTEN, GLI3, TGFB2, BDNF, HTRA2, CD44, CXCR4, PAX7, ILK, 481 438 13528 3.981128 5.48E-17 5.71E-19 2.61E-17
EGFR, RET, MYO6, EGR2, RXRA, EFNB1, HES1, PRKCQ, PSEN1, HES5, FOXG1, VEGFA, MNX1,
EFNA5, NGFR, BBS4, FGFR1, ERBB3, DRD2, ERBB2, SRF, EPHB2, HOXA1, IGF1R, ALDH1A2,
HOXA2
GO:0001944~vasculature development 1.46E-20 CAV1, LEPR, IL18, FGF10, SRF, PTEN, WT1, TGFB2, CITED2, MAP3K7, AKT1, PTK2, CHD7, CD44, 481 251 13528 5.266386 5.68E-17 5.86E-19 2.71E-17
CXCR4, CTGF, APOE, CASP8, GBX2, TGFA, QKI, NOS3, NKX2-5, FGF2, RASA1, BMP4, KLF5,
SELP, TGFBR2, MMP14, KDR, ATP7A, NOTCH1, CRKL, PSEN1, MEOX2, ID1, MAPK14, JUN, BAX,
V
GO:0002521~leukocyte differentiation 1.79E-20 TNF, BLM, MMP9, STAT5A, CSF1, STAT5B, PPARG, RAG1, PRKDC, SOX4, RAG2, KIT, TGFB1, 481 131 13528 7.514244 6.95E-17 7.09E-19 3.31E-17
ADA, CBFB, CHD7, BCL2, CASP8, ZAP70, FAS, CHUK, SYK, APC, EGR1, PTPRC, TGFBR2, TP53,
ATP7A, HDAC4, PSEN1, BAX, PSEN2, PLCG2, ADAM17, TSHR
GO:0009952~anterior/posterior pattern 1.83E-20 FOXA2, PAX6, PRKDC, GLI3, ZIC3, HOXA1, ALDH1A2, HOXA2, GATA4, GBX2, APC, MLL, HTT, 481 140 13528 7.232076 7.13E-17 7.20E-19 3.40E-17 formation MYF5, SMAD4, DLL3, LEF1, SMAD2, HES1, CTNNBIP1, HHEX, ACVR2A, HOXB1, NOTCH1,
CRKL, EP300, PSEN1, MEOX2, HIPK1, HOXC13, HIPK2, PSEN2, GDF11, NEUROD1, ROR2, PBX1
GO:0051253~negative regulation of RNA 2.11E-20 MEF2C, E2F1, FST, PPARG, SPI1, TP63, NFKB1, PAX3, ZEB1, PAX2, GLI2, DAXX, CITED2, MEN1, 481 362 13528 4.350789 8.19E-17 8.19E-19 3.91E-17 metabolic process RARB, FGF2, TWIST2, EGR1, RARG, GSC, RXRA, RBL1, TP53, LEF1, RB1, HES1, CTNNBIP1,
HHEX, HES5, HIPK2, TNF, SOX9, WT1, VDR, HOXA2, POU2F1, NKX2-1, GFI1, NKX2-5, HELLS, B
GO:0051960~regulation of nervous 4.15E-20 XRCC5, NOG, NBN, FOXA2, DRD2, PPARG, PAX6, KIT, GLI2, TGFB1, EPHB2, HOXA2, PTK2, 481 192 13528 6.005804 1.61E-16 1.60E-18 7.69E-17 system development BDNF, APOE, BCL2, ILK, NKX2-5, SNAP25, FGF2, SPP1, BMP4, BMP2, LYN, GRIN1, DLL3, TP53, IGF1, SMAD1, HES1, EYA1, NOTCH1, HES5, PSEN1, FOXG1, SIX1, NEUROD1, PBX1, NGFR,
CHRD, E
GO:0007169~transmembrane receptor 4.32E-20 FGFR2, FGFR1, ERBB4, GRB2, ERBB3, STAT5A, ERBB2, STAT5B, FGF10, KIT, PTEN, SRC, TGFB1, 481 224 13528 5.524503 1.68E-16 1.65E-18 8.01E-17 protein tyrosine kinase signaling pathway EPHB2, AKT1, IGF1R, PTK2, CTGF, INS, SOS1, NRG1, FGF2, INSR, AKT2, GHR, CSF1R, EGFR,
RET, MET, CBL, IGF2, IRS1, STAT3, KDR, PRLR, VEGFA, TSC2, FOXC2, ROR2, ADAM17, PDGF
GO:0009628~response to abiotic stimulus 4.61E-20 HRAS, IL18, PPARG, TGFB1, AKT1, MEN1, FOS, PDPK1, CASP9, HSF1, CDKN2D, MKKS, NOS3, 481 368 13528 4.279852 1.79E-16 1.74E-18 8.53E-17
H2AFX, MYC, EGFR, LYN, TP53, MBD4, MMP14, PRKCQ, EYA1, CCND1, THBD, JUN, HSPB2,
MAPK8, NGFR, COL1A1, CAV1, TNF, BLM, DRD2, NEK1, HUS1, PRKDC, KIT, BCL2, NKX2-1,
GFI1, ERCC2
GO:0007568~aging 6.39E-20 HRAS, GRB2, SLC6A3, PTGS1, PTH1R, TGFB3, TP63, SRF, PTEN, PDCD4, TGFB1, ADA, FOS, 481 110 13528 8.181743 2.48E-16 2.39E-18 1.18E-16
CDKN2A, BCL2, ILK, NOS3, INPP5D, TERT, ERCC2, HTT, POLG, RXRA, TP53, BRCA2, SIRT1,
PRKCD, PRKCQ, PLA2G4A, JUN, LRP2, ENG
GO:0010627~regulation of protein kinase 6.93E-20 CAV1, TNF, DRD2, ERBB3, LEPR, ERBB2, MAP4K1, FASLG, TLR4, DAXX, PDCD4, PTEN, TGFB1, 481 249 13528 5.195735 2.69E-16 2.57E-18 1.28E-16 cascade TGFB2, MAP3K7, MEN1, AKT1, TNFRSF1A, NOD2, MYD88, REL, INS, ILK, CASP8, INSR, AXIN1,
GHR, SYK, APC, AKT2, PTPRC, LYN, NF2, SOCS1, IGF1, IGF2, FADD, TP73, IKBKE, HIPK2, TSC
GO:0030155~regulation of cell adhesion 8.38E-20 TNF, ERBB3, STAT5A, IL18, ERBB2, CSF1, STAT5B, PTEN, TGFB1, SRC, ADA, CITED2, TGFB2, 481 137 13528 7.185153 3.26E-16 3.07E-18 1.55E-16
CDKN2A, BCL2, ILK, NRG1, RASA1, APC, SPP1, GTPBP4, NF2, MYF5, SMAD3, CDK6, MMP14,
VAV1, CD36, PRLR, TSC1, TSC2, JAK2, COL1A1, CHRD, ENG
GO:0001763~morphogenesis of a 1.31E-19 FOXA2, DRD2, FGF10, GLI2, PAX2, GLI3, TGFB1, CD44, CXCR4, BCL2, ILK, GBX2, BMP4, BMP2, 481 74 13528 10.26173 5.09E-16 4.76E-18 2.43E-16 branching structure TGFBR2, SMAD4, IGF1, MMP14, KDR, NOTCH1, EYA1, SIX1, VEGFA, FOXC2, PBX1, ENG,
ACVR1
GO:0042592~homeostatic process 2.20E-19 XRCC5, NBN, MAEA, STAT5A, PPARG, SNCA, STAT5B, CXCR3, TGFB1, AKT1, MEN1, EDNRB, 481 751 13528 3.033427 8.54E-16 7.91E-18 4.07E-16
DKC1, APOE, CXCR4, COL4A3BP, ILK, QKI, FAS, INSR, MYC, TERT, EGR2, LYN, CCKBR, TP53,
RB1, PPARGC1A, IRS1, RAD50, PTHLH, EP300, PSEN1, JUN, VEGFA, PDGFRB, PRNP, BBS4,
CAV1, BLM
GO:0060348~bone development 2.25E-19 NOG, ACHE, PTH1R, TGFB3, COL2A1, SOX9, GLI2, TGFB1, CBFB, MEN1, HOXA2, CTGF, INS, 481 123 13528 7.545662 8.74E-16 8.02E-18 4.17E-16 BCL2, RUNX2, GHR, ERCC2, SPP1, BMP4, EGFR, BMP2, SMAD5, SMAD3, IGF1, IGF2, SMAD1,
MMP14, PTHLH, FOXC2, FOXC1, MAPK8, COL1A1, CHRD, EIF2AK3
GO:0006350~transcription 2.66E-19 MEF2C, THRB, STAT5A, STAT5B, TBP, CBFB, ZIC3, PNN, CITED2, GATA1, FLI1, CDKN2A, 481 2101 13528 2.034727 1.04E-15 9.41E-18 4.93E-16
GATA3, GATA4, RARA, RARB, MLL4, TWIST2, PITX1, IKBKAP, RARG, RBL2, RXRA, RBL1,
PPARGC1A, HES1, HHEX, KDM2B, EP300, HES5, JUN, FOXG1, MNX1, TFAP2A, TFB1M, XRN2,
SOX4, SOX9, SRF
GO:0048562~embryonic organ 2.98E-19 NOG, TGFB3, FGF10, COL2A1, ZEB1, PAX2, GLI2, GLI3, MEN1, HOXA1, HOXA2, CHD7, GATA4, 481 133 13528 7.189783 1.16E-15 1.04E-17 5.51E-16 morphogenesis GBX2, NKX3-2, GFI1, RARB, MYC, RARG, MYO6, GSC, MAFB, MYF5, TGFBR2, HOXB1, EYA1,
DLX6, DLX5, SIX1, FOXG1, FOXC2, NEUROD1, TFAP2A, ROR2
GO:0030900~forebrain development 3.24E-19 E2F1, BBS4, NOG, ERBB4, DRD2, SLC6A3, PAX6, GLI2, GLI3, SRC, ALDH1A2, HTRA2, MKKS, 481 152 13528 6.661123 1.26E-15 1.13E-17 6.01E-16
NKX2-1, PAFAH1B1, PITX1, BMP4, GSC, HTT, GRIN1, LEF1, TP73, FOXP2, HES1, ATP7A, HHEX,
NOTCH1, EYA1, TSC1, PSEN1, BAX, PSEN2, FOXG1, APAF1, LRP2, CHRD
GO:0060429~epithelium development 5.03E-19 LOR, BBS4, FOXA2, ELF3, PPARG, PAX6, TP63, PAX3, SFN, PAX2, GLI2, GLI3, WT1, MAP3K7, 481 227 13528 5.327594 1.96E-15 1.73E-17 9.32E-16
ALDH1A2, CD44, BCL2, POU2F3, ILK, CASP8, MKKS, NKX2-1, CHUK, BMP4, BMP2, RET, HTT,
SMAD4, FZD2, KDR, PTHLH, EYA1, TSC1, DLX6, JUN, DLX5, VEGFA, SIX1, TSC2, TFAP2A,
PBX1,
GO:0009611~response to wounding 6.20E-19 NOG, FOXA2, S100A8, ELF3, STAT5B, TGFB3, IL13, FGF10, NFKB1, TLR4, TGFB1, TGFB2, AKT1, 481 530 13528 3.502326 2.41E-15 2.11E-17 1.15E-15
FOS, MYD88, CD44, CTGF, CXCR4, PAX7, NRG1, FGF2, LYN, RXRA, WAS, PRKCQ, CD36, THBD,
ADAM17, NGFR, ACVR1, ACHE, TNF, ERBB3, ERBB2, ITGB3, SRF, TNFRSF1A, TNFRSF1B, INS, B
GO:0018108~peptidyl-tyrosine 6.76E-19 ERBB4, LYN, ERBB3, ERBB2, STAT5A, KIT, FES, STAT1, SRC, EPHB2, BTK, TYK2, PRLR, ZAP70, 481 46 13528 13.45096 2.63E-15 2.29E-17 1.25E-15 phosphorylation JAK1, PDGFRB, JAK2, ABL1, INSR, F2R, SYK, GHR
GO:0048754~branching morphogenesis of 8.75E-19 FOXA2, FGF10, GLI2, PAX2, GLI3, CD44, CXCR4, BCL2, ILK, GBX2, BMP4, BMP2, TGFBR2, 481 65 13528 10.81721 3.40E-15 2.93E-17 1.62E-15 a tube SMAD4, IGF1, MMP14, KDR, NOTCH1, EYA1, SIX1, VEGFA, FOXC2, PBX1, ENG, ACVR1
GO:0048514~blood vessel morphogenesis 1.46E-18 CAV1, IL18, LEPR, FGF10, SRF, PTEN, WT1, CITED2, TGFB2, MAP3K7, PTK2, CXCR4, CTGF, 481 211 13528 5.464997 5.67E-15 4.85E-17 2.70E-15
APOE, CASP8, GBX2, TGFA, QKI, NOS3, NKX2-5, FGF2, RASA1, BMP4, KLF5, SELP, TGFBR2,
MMP14, KDR, ATP7A, NOTCH1, MEOX2, ID1, MAPK14, JUN, BAX, VEGFA, FOXC2, FOXC1, ENG, PLAU,
GO:0001822~kidney development 1.49E-18 NOG, PAX2, GLI2, GLI3, WT1, ALDH1A2, BDNF, CD44, BCL2, PAX8, ILK, RARB, APC, BMP4, 481 96 13528 8.496015 5.79E-15 4.91E-17 2.76E-15
RET, BMP2, SOX11, SMAD4, LEF1, SMAD1, EYA1, TSC1, BAX, SIX1, GDF11, PDGFRB, FOXC2,
PBX1, FOXC1
GO:0018212~peptidyl-tyrosine 2.03E-18 ERBB4, LYN, ERBB3, ERBB2, STAT5A, KIT, FES, STAT1, SRC, EPHB2, BTK, TYK2, PRLR, ZAP70, 481 48 13528 12.89051 7.88E-15 6.62E-17 3.76E-15 modification JAK1, PDGFRB, JAK2, ABL1, INSR, F2R, SYK, GHR
GO:0051272~positive regulation of cell 2.74E-18 ERBB4, MMP9, CSF1, STAT5B, KIT, TGFB1, TGFB2, IGF1R, INS, BCL2, ILK, INSR, FGF2, APC, 481 98 13528 8.322627 1.06E-14 8.87E-17 5.07E-15 motion EGFR, LYN, SPHK1, SMAD3, IGF1, IGF2, IRS1, KDR, MAPK1, ETS1, VEGFA, ADAM17, PDGFRB,
JAK2, F2R, HDAC6
GO:0001503~ossification 2.81E-18 NOG, ACHE, PTH1R, TGFB3, COL2A1, GLI2, TGFB1, CBFB, MEN1, HOXA2, CTGF, INS, BCL2, 481 115 13528 7.581452 1.09E-14 9.04E-17 5.21E-15
RUNX2, ERCC2, SPP1, BMP4, EGFR, BMP2, SMAD5, SMAD3, IGF1, IGF2, SMAD1, MMP14,
PTHLH, FOXC2, FOXC1, MAPK8, COL1A1, EIF2AK3, CHRD
GO:0016265~death 4.58E-18 E2F1, MEF2C, HRAS, TP63, FASLG, NFKB1, TBP, PAX3, DAXX, PDCD4, PTEN, TGFB1, TGFB2, 481 724 13528 2.991167 1.78E-14 1.46E-16 8.49E-15
AKT1, CDKN2A, HTRA2, CASP9, CXCR4, CDKN2D, CASP8, FAS, CASP2, FGF2, MYC, TOP2A, AR,
TP53, FADD, STK4, EP300, PSEN1, JUN, HIPK2, PSEN2, RIPK3, MAPK8, NGFR, MAPK7, TNFAIP3,
E
GO:0045321~leukocyte activation 5.84E-18 NBN, BLM, STAT5A, CSF1, STAT5B, SNCA, RAG1, PRKDC, SOX4, TLR4, RAG2, CBFB, TGFB1, 481 242 13528 4.997371 2.27E-14 1.85E-16 1.08E-14
ADA, CHD7, CXCR4, INS, BCL2, ZAP70, FAS, HELLS, SYK, APC, EGR1, PTPRC, LYN, TGFBR2,
TP53, SMAD3, IGF2, FOXP3, VAV1, WAS, PRKCD, ATP7A, HDAC4, PRLR, PSEN1, BAX, PSEN2,
PLCG2,
GO:0050767~regulation of neurogenesis 6.49E-18 XRCC5, NOG, NBN, FOXA2, DRD2, PPARG, PAX6, KIT, GLI2, TGFB1, EPHB2, HOXA2, PTK2, 481 166 13528 6.099341 2.52E-14 2.04E-16 1.20E-14
BDNF, APOE, BCL2, ILK, NKX2-5, SPP1, BMP4, BMP2, LYN, GRIN1, TP53, DLL3, SMAD1, HES1,
EYA1, NOTCH1, HES5, PSEN1, FOXG1, SIX1, NEUROD1, PBX1, NGFR
GO:0009991~response to extracellular 6.81E-18 CAV1, LEPR, PPARG, PTEN, AQP3, TGFB1, AKT1, CCNE1, ALDH1A2, VDR, FOS, CD44, CDKN2D, 481 220 13528 5.241429 2.65E-14 2.12E-16 1.26E-14 stimulus BCL2, RARA, OGT, INSR, SPP1, GHR, BMP4, BMP2, RARG, LYN, RXRA, TGFBR2, CSNK2B, TP53,
BRCA2, STAT1, SIRT1, PPARGC1A, PLA2G4A, CDKN1A, CCND1, PSEN1, JUN, MTOR, ALOX5, COL1A1
GO:0008219~cell death 1.11E-17 E2F1, MEF2C, HRAS, TP63, FASLG, NFKB1, TBP, PAX3, DAXX, PDCD4, PTEN, TGFB1, TGFB2, 481 719 13528 2.972852 4.33E-14 3.44E-16 2.07E-14
AKT1, CDKN2A, HTRA2, CASP9, CXCR4, CDKN2D, CASP8, FAS, CASP2, FGF2, MYC, TOP2A, AR,
TP53, FADD, STK4, EP300, PSEN1, JUN, HIPK2, PSEN2, RIPK3, MAPK8, NGFR, MAPK7, TNFAIP3,
E
GO:0044092~negative regulation of 1.23E-17 NOG, LEPR, SNCA, PPARG, NFKB1, PDCD4, LATS2, TGFB2, AKT1, MEN1, EDNRB, NOD2, PDPK1, 481 334 13528 4.21029 4.79E-14 3.77E-16 2.28E-14 molecular function CDKN2A, APOE, CDKN2D, ILK, NOS3, INSR, GTPBP4, TP53, RB1, PRKCD, PTHLH, PSEN1, CAV1,
DRD2, RAG1, SFN, INS, FBXO5, GFI1, APC, PTPRC, NF2, IGF2, BIRC5, FOXP3, SIRT1, TP73, A
GO:0043193~positive regulation of 1.31E-17 MEF2C, TNF, PPARG, TGFB3, SPI1, PRKDC, SRF, ARNT, CITED2, NR1H2, GATA4, NKX2-5, TP53, 481 87 13528 8.728368 5.07E-14 3.96E-16 2.42E-14 gene-specific transcription IGF1, SMAD3, SMAD2, ESR2, FOXP3, PPARGC1A, HES1, HDAC4, HHEX, NOTCH1, HES5, ETS1,
NR5A2, ENG
GO:0012501~programmed cell death 1.58E-17 E2F1, MEF2C, HRAS, TP63, FASLG, NFKB1, PAX3, DAXX, PDCD4, PTEN, AKT1, CDKN2A, 481 611 13528 3.176116 6.12E-14 4.75E-16 2.92E-14
HTRA2, CASP9, CXCR4, CDKN2D, CASP8, FAS, CASP2, FGF2, TOP2A, MYC, TP53, FADD, STK4,
EP300, PSEN1, JUN, HIPK2, PSEN2, RIPK3, MAPK8, NGFR, MAPK7, TNFAIP3, EIF2AK3, BID, TNF,
ERBB3
GO:0051130~positive regulation of 1.59E-17 BBS4, CAV1, TNF, SNCA, TGFB3, FGF10, KIT, SRF, TGFB1, TGFB2, MEN1, AKT1, PDPK1, INS, 481 181 13528 5.749256 6.18E-14 4.76E-16 2.95E-14 cellular component organization ILK, TGFA, NKX2-5, INSR, HIP1, APC, NF2, CBL, SMAD4, SMAD3, IGF1, IGF2, SMAD2, SMAD1,
FOXP3, PPARGC1A, PRKCQ, PLA2G4A, CDKN1B, TSC1, DNMT1, MTOR, NGFR, HDAC6
GO:0001775~cell activation 2.11E-17 NBN, TNF, BLM, STAT5A, CSF1, STAT5B, SNCA, RAG1, PRKDC, SOX4, TLR4, RAG2, CBFB, 481 287 13528 4.507798 8.19E-14 6.25E-16 3.90E-14
TGFB1, ADA, CHD7, CXCR4, INS, BCL2, ZAP70, FAS, HELLS, SYK, APC, EGR1, EGFR, PTPRC,
LYN, TGFBR2, TP53, SMAD3, IGF2, FOXP3, VAV1, WAS, PRKCD, ATP7A, HDAC4, PRLR, PSEN1,
BAX, PS
GO:0032844~regulation of homeostatic 2.18E-17 CAV1, DRD2, STAT5A, STAT5B, SPI1, ADA, TGFB1, ARNT, TAL1, ACVR1B, CD44, BCL2, INPP5D, 481 114 13528 7.401247 8.49E-14 6.43E-16 4.05E-14 process MYC, SPP1, PTPRC, IL2RA, NOS1, LYN, MAFB, CDK6, ACVR2A, PLA2G4A, ETS1, MAPK14, BAX,
VEGFA, ADAM17, EIF2AK3, F2R
GO:0042327~positive regulation of 2.32E-17 CAV1, TNF, TGFB3, KITLG, TLR4, TGFB1, EDNRB, NOD2, INS, BCL2, FGF2, INSR, AXIN1, GHR, 481 97 13528 8.118482 9.02E-14 6.78E-16 4.30E-14 phosphorylation SYK, BMP4, EGFR, BMP2, LYN, SMAD4, IGF1, IGF2, ACVR2A, CCND1, PSEN1, ADAM17, JAK2,
MTOR, ENG
GO:0001934~positive regulation of 2.44E-17 CAV1, TNF, TGFB3, KITLG, TLR4, TGFB1, EDNRB, NOD2, INS, BCL2, FGF2, INSR, AXIN1, GHR, 481 89 13528 8.532225 9.50E-14 7.09E-16 4.53E-14 protein amino acid phosphorylation SYK, BMP4, BMP2, LYN, SMAD4, IGF1, IGF2, ACVR2A, CCND1, PSEN1, ADAM17, JAK2, MTOR,
ENG
GO:0051098~regulation of binding 2.84E-17 NOG, TNF, BLM, TLR4, TGFB1, MEN1, NOD2, MYD88, CDKN2A, BCL2, BRD4, NRG1, APEX1, 481 153 13528 6.249942 1.10E-13 8.18E-16 5.26E-14
ERCC2, GTPBP4, SMAD4, SMAD3, SMAD2, ATR, FOXP3, SIRT1, PRKCD, PTHLH, HDAC4,
PRKCQ, EP300, PSEN1, ID1, BAX, HIPK2, PBX1, JAK2, IKBKB, EIF2AK3
GO:0031667~response to nutrient levels 4.05E-17 CAV1, LEPR, PPARG, PTEN, AQP3, TGFB1, AKT1, CCNE1, VDR, ALDH1A2, CD44, CDKN2D, 481 197 13528 5.425077 1.57E-13 1.16E-15 7.50E-14
BCL2, RARA, OGT, INSR, SPP1, GHR, BMP4, BMP2, RARG, RXRA, TGFBR2, CSNK2B, TP53,
BRCA2, STAT1, SIRT1, PPARGC1A, PLA2G4A, CCND1, PSEN1, JUN, MTOR, ALOX5, COL1A1,
LRP2, HDAC6
GO:0051247~positive regulation of 4.16E-17 CAV1, TNF, CSF1, TGFB3, KITLG, TLR4, TGFB1, AKT1, MEN1, NR1H2, EDNRB, NOD2, INS, 481 243 13528 4.861066 1.62E-13 1.18E-15 7.70E-14 protein metabolic process APOE, BCL2, FBXO5, FGF2, INSR, AXIN1, APC, GHR, SYK, BMP4, CDK1, BMP2, LYN, SMAD4,
IGF1, IGF2, FOXP3, PPARGC1A, BRCA1, HDAC4, MAPK1, ACVR2A, CCND1, EP300, PSEN1,
ADAM17, DNMT
GO:0048609~reproductive process in a 5.27E-17 STAT5A, SLC6A3, LEPR, FST, STAT5B, TGFB3, TBP, TGFB1, TGFB2, CITED2, AKT1, MEN1, 481 487 13528 3.46506 2.05E-13 1.48E-15 9.76E-14 multicellular organism CCNE1, HSF1, CXCR4, MKKS, QKI, H2AFX, NOS3, OCA2, EGFR, MMP14, PTHLH, ACVR2A,
VEGFA, FOXC1, XRN2, ACVR1, BBS4, CAV1, ERBB2, PRKDC, KIT, WT1, BCL2, NKX2-1, FBXO5,
PAFAH1B1, SP
GO:0032504~multicellular organism 5.27E-17 STAT5A, SLC6A3, LEPR, FST, STAT5B, TGFB3, TBP, TGFB1, TGFB2, CITED2, AKT1, MEN1, 481 487 13528 3.46506 2.05E-13 1.48E-15 9.76E-14 reproduction CCNE1, HSF1, CXCR4, MKKS, QKI, H2AFX, NOS3, OCA2, EGFR, MMP14, PTHLH, ACVR2A,
VEGFA, FOXC1, XRN2, ACVR1, BBS4, CAV1, ERBB2, PRKDC, KIT, WT1, BCL2, NKX2-1, FBXO5,
PAFAH1B1, SP
GO:0010562~positive regulation of 5.44E-17 CAV1, TNF, TGFB3, KITLG, TLR4, TGFB1, EDNRB, NOD2, INS, BCL2, FGF2, INSR, AXIN1, GHR, 481 100 13528 7.874927 2.11E-13 1.52E-15 1.01E-13 phosphorus metabolic process SYK, BMP4, EGFR, BMP2, LYN, SMAD4, IGF1, IGF2, ACVR2A, CCND1, PSEN1, ADAM17, JAK2, MTOR, ENG
GO:0045937~positive regulation of 5.44E-17 CAV1, TNF, TGFB3, KITLG, TLR4, TGFB1, EDNRB, NOD2, INS, BCL2, FGF2, INSR, AXIN1, GHR, 481 100 13528 7.874927 2.11E-13 1.52E-15 1.01E-13 phosphate metabolic process SYK, BMP4, EGFR, BMP2, LYN, SMAD4, IGF1, IGF2, ACVR2A, CCND1, PSEN1, ADAM17, JAK2,
MTOR, ENG
GO:0032270~positive regulation of 5.47E-17 CAV1, TNF, CSF1, TGFB3, KITLG, TLR4, TGFB1, AKT1, MEN1, NR1H2, EDNRB, NOD2, INS, 481 233 13528 4.948989 2.13E-13 1.52E-15 1.01E-13 cellular protein metabolic process APOE, BCL2, FBXO5, FGF2, INSR, AXIN1, GHR, SYK, BMP4, CDK1, BMP2, LYN, SMAD4, IGF1,
IGF2, FOXP3, PPARGC1A, BRCA1, HDAC4, MAPK1, ACVR2A, CCND1, EP300, PSEN1, ADAM17,
DNMT1, JA
GO:0033554~cellular response to stress 7.06E-17 XRCC5, NBN, SNCA, TP63, DAXX, MEN1, FOS, CASP9, CDKN2D, COL4A3BP, H2AFX, TOP2A, 481 566 13528 3.229873 4.32E-13 3.11E-15 2.11E-13
CCNA2, MAP2K7, FANCA, SYK, CDK1, MYO6, LYN, POLG, RXRA, TP53, MBD4, RAD50, MAPK1,
EYA1, CCND1, CRKL, HIPK1, PSEN1, JUN, HIPK2, ROR2, MAPK9, MAPK8, EIF2AK3, WNT5A,
CAV1, TNF, B
GO:0030278~regulation of ossification 1.11E-16 THRB, CSF1, TGFB3, SOX9, TGFB1, TGFB2, MEN1, BCL2, RUNX2, TWIST2, APC, BMP4, BMP2, 481 78 13528 9.01434 4.32E-13 3.00E-15 2.11E-13
EGR2, SMAD5, SMAD3, CDK6, SMAD1, ACVR2A, PLA2G4A, DLX5, PBX1, BMPR1B, CHRD,
ACVR1
GO:0048666~neuron development 1.14E-16 PAX6, GLI2, PAX2, PTEN, TGFB2, BDNF, CD44, HTRA2, CXCR4, ILK, EGFR, RET, EGR2, MYO6, 481 339 13528 4.065228 4.32E-13 3.00E-15 2.11E-13
RXRA, EFNB1, HES1, PSEN1, FOXG1, VEGFA, EFNA5, NGFR, BBS4, FGFR1, DRD2, ERBB3,
ERBB2, SRF, EPHB2, HOXA1, IGF1R, PTK2, HOXA2, BCL2, GBX2, NKX2-1, PAFAH1B1, SNAP25,
RUNX3,
GO:0001656~metanephros development 1.18E-16 BMP4, RET, NOG, BMP2, SMAD4, PAX2, GLI3, WT1, BDNF, EYA1, CD44, BCL2, PAX8, ILK, SIX1, 481 44 13528 12.78397 4.32E-13 3.00E-15 2.11E-13
GDF11, FOXC2, PBX1, FOXC1, RARB
GO:0051329~interphase of mitotic cell 1.23E-16 E2F1, BLM, LATS2, AKT1, ACVR1B, CCNE1, CDKN2A, CDKN2C, BCL2, CDKN2D, NPAT, GFI1, 481 103 13528 7.64556 4.32E-13 3.00E-15 2.11E-13 cycle CDCA5, EGFR, CDC7, CDK6, BIRC5, RB1, CDC25C, CDK2, CDC25A, CDKN1C, CDKN1A, CCND1,
CDKN1B, ADAM17, ABL1, ACVR1
GO:0007346~regulation of mitotic cell 1.83E-16 NBN, TNF, MAEA, STAT5A, HUS1, STAT5B, TGFB1, CDKN2A, INS, BCL2, FBXO5, TGFA, AATF, 481 152 13528 6.106029 8.63E-13 5.88E-15 4.11E-13 cycle INSR, CCNA2, MYC, DLG1, APC, EGFR, CDK1, SPHK1, TP53, SMAD3, BRCA2, IGF1, IGF2, BIRC5, RB1, CDC25C, CDK2, PRKCQ, CCND1, FOXG1, FOXC1
GO:0042326~negative regulation of 1.97E-16 PTPRC, CAV1, NF2, SOCS1, PRKCD, TGFB1, MEN1, CDKN1C, CDKN1A, CDKN2A, CDKN1B, 481 45 13528 12.49988 8.63E-13 5.88E-15 4.11E-13 phosphorylation PSEN1, CDKN2C, ATXN7, JUN, BAX, CDKN2D, PSEN2, INSR, ENG
GO:0000122~negative regulation of 1.99E-16 MEF2C, E2F1, TNF, FST, PPARG, SPI1, TP63, NFKB1, PAX3, ZEB1, PAX2, GLI2, WT1, CITED2, 481 266 13528 4.546481 8.63E-13 5.88E-15 4.11E-13 transcription from RNA polymerase II MEN1, VDR, HOXA2, NKX2-1, GFI1, RARB, NKX2-5, EGR1, RARG, GSC, RXRA, RBL1, TP53, promoter SMAD3, LEF1, RB1, STAT3, FOXP2, HES1, CTNNBIP1, CDKN1C, HDAC4, HHEX, HES5, ID1,
HIPK2, D
GO:0043627~response to estrogen 2.10E-16 CAV1, LEPR, PPARG, STAT5B, TGFB3, AQP1, PTEN, TGFB1, CCNE1, ALDH1A2, BCL2, GATA3, 481 105 13528 7.499931 8.63E-13 5.77E-15 4.11E-13 stimulus NOS3, RARA, CCNA2, NKX2-5, INSR, GHR, BMP4, TGFBR2, SOCS1, ESR1, BRCA2, MMP14,
STAT3, BRCA1, MAPK1, CCND1
GO:0007166~cell surface receptor linked 2.21E-16 NOG, HRAS, STAT5A, STAT5B, FST, TGFB3, FGF10, TGFB1, TGFB2, CSNK2A2, MAP3K7, 481 1856 13528 2.030558 8.63E-13 5.77E-15 4.11E-13 signal transduction CSNK2A1, MYD88, GAB2, CTGF, APOE, ILK, INSR, SYK, EGFR, RET, RARG, DLL3, IRS1, STK4,
PTHLH, HHEX, MAPK1, ARRB2, JUN, VEGFA, PDGFRB, ROR2, EIF2AK3, FGFR2, WNT5A, FGFR1,
ERBB4, GRB
GO:0051325~interphase 2.72E-16 E2F1, BLM, LATS2, AKT1, ACVR1B, CCNE1, CDKN2A, CDKN2C, BCL2, CDKN2D, NPAT, GFI1, 481 106 13528 7.429177 8.63E-13 5.66E-15 4.11E-13
CDCA5, EGFR, CDC7, CDK6, BIRC5, RB1, CDC25C, CDK2, CDC25A, CDKN1C, CDKN1A, CCND1,
CDKN1B, ADAM17, ABL1, ACVR1
GO:0030335~positive regulation of cell 2.83E-16 ERBB4, CSF1, MMP9, KIT, TGFB1, TGFB2, IGF1R, INS, BCL2, ILK, INSR, FGF2, APC, EGFR, 481 89 13528 8.216216 1.29E-12 8.55E-15 6.22E-13 migration SPHK1, SMAD3, IGF1, IGF2, IRS1, KDR, MAPK1, VEGFA, ADAM17, PDGFRB, JAK2, F2R, HDAC6
GO:0040017~positive regulation of 3.32E-16 ERBB4, CSF1, MMP9, FGF10, KIT, TGFB1, TGFB2, IGF1R, INS, BCL2, ILK, INSR, FGF2, APC, 481 98 13528 7.748653 1.29E-12 8.44E-15 6.22E-13 locomotion EGFR, SPHK1, SMAD3, IGF1, IGF2, IRS1, KDR, MAPK1, VEGFA, ADAM17, PDGFRB, JAK2, F2R,
HDAC6
GO:0042110~T cell activation 3.96E-16 BLM, STAT5A, STAT5B, RAG1, PRKDC, SOX4, RAG2, ADA, TGFB1, CHD7, CXCR4, INS, BCL2, 481 126 13528 6.696367 1.73E-12 1.12E-14 8.22E-13
ZAP70, FAS, SYK, APC, EGR1, PTPRC, TP53, SMAD3, IGF2, FOXP3, VAV1, WAS, ATP7A, PRLR,
PSEN1, BAX, PSEN2, ADAM17
GO:0001657~ureteric bud development 4.11E-16 BMP4, RET, NOG, BMP2, SMAD4, PAX2, GLI3, BDNF, EYA1, CD44, BCL2, ILK, SIX1, GDF11, 481 35 13528 14.46415 1.73E-12 1.11E-14 8.22E-13 FOXC2, PBX1, FOXC1, RARB
GO:0042698~ovulation cycle 4.50E-16 EGFR, BMP4, BMP2, TAF4, STAT5A, LEPR, ERBB2, STAT5B, TGFB3, MMP14, SIRT1, TGFB2, 481 67 13528 9.654762 1.73E-12 1.11E-14 8.22E-13
KDR, CCNE1, PLA2G4A, BAX, BCL2, VEGFA, NKX2-1, NOS3, FOXC1, BMPR1B, NR5A1
GO:0060541~respiratory system 4.52E-16 WNT5A, FOXA2, TGFB3, FGF10, GLI2, GLI3, ADA, ALDH1A2, CHD7, CTGF, POU2F1, NKX2-1, 481 108 13528 7.291599 1.73E-12 1.10E-14 8.22E-13 development NOS3, HHIP, FGF2, BMP4, TGFBR2, SMAD2, MMP14, FOXP2, KDR, ATP7A, PTHLH, HES1,
NOTCH1, EP300, VEGFA, PSEN2
GO:0046649~lymphocyte activation 4.88E-16 NBN, BLM, STAT5A, STAT5B, RAG1, PRKDC, SOX4, RAG2, TGFB1, ADA, CBFB, CHD7, CXCR4, 481 199 13528 5.229223 1.73E-12 1.09E-14 8.22E-13
INS, BCL2, ZAP70, FAS, HELLS, SYK, APC, EGR1, PTPRC, TP53, SMAD3, IGF2, FOXP3, VAV1,
PRKCD, WAS, ATP7A, HDAC4, PRLR, PSEN1, BAX, PSEN2, PLCG2, ADAM17, TSHR
GO:0045936~negative regulation of 8.38E-16 PTPRC, CAV1, NF2, SOCS1, PRKCD, TGFB1, MEN1, CDKN1C, CDKN1A, CDKN2A, CDKN1B, 481 48 13528 11.71864 3.45E-12 2.18E-14 1.64E-12 phosphate metabolic process PSEN1, CDKN2C, ATXN7, JUN, BAX, CDKN2D, PSEN2, INSR, ENG
GO:0010563~negative regulation of 8.38E-16 PTPRC, CAV1, NF2, SOCS1, PRKCD, TGFB1, MEN1, CDKN1C, CDKN1A, CDKN2A, CDKN1B, 481 48 13528 11.71864 3.45E-12 2.18E-14 1.64E-12 phosphorus metabolic process PSEN1, CDKN2C, ATXN7, JUN, BAX, CDKN2D, PSEN2, INSR, ENG
GO:0001649~osteoblast differentiation 8.92E-16 BMP4, NOG, ACHE, BMP2, PTH1R, SMAD5, SMAD3, IGF1, IGF2, SMAD1, GLI2, CBFB, PTHLH, 481 42 13528 12.7231 3.45E-12 2.15E-14 1.64E-12
MEN1, HOXA2, INS, COL1A1, RUNX2, CHRD, SPP1
GO:0046660~female sex differentiation 1.02E-15 BMP4, TAF4, STAT5A, LEPR, STAT5B, FST, BRCA2, TP63, MMP14, SIRT1, KDR, CCNE1, 481 69 13528 9.374913 3.88E-12 2.41E-14 1.85E-12
PLA2G4A, CHD7, BAX, BCL2, VEGFA, NKX2-1, NOS3, FOXC1, BMPR1B, FANCA, NR5A1
GO:0046545~development of primary 1.02E-15 BMP4, TAF4, STAT5A, LEPR, STAT5B, FST, BRCA2, TP63, MMP14, SIRT1, KDR, CCNE1, 481 69 13528 9.374913 3.88E-12 2.41E-14 1.85E-12 female sexual characteristics PLA2G4A, CHD7, BAX, BCL2, VEGFA, NKX2-1, NOS3, FOXC1, BMPR1B, FANCA, NR5A1
GO:0048705~skeletal system 1.32E-15 NOG, TGFB3, COL2A1, ZEB1, SOX9, GLI3, TGFB1, MEN1, HOXA2, CTGF, NKX3-2, MYC, RUNX2, 481 112 13528 7.031185 5.18E-12 3.20E-14 2.46E-12 morphogenesis GHR, GSC, MYF5, TGFBR2, PTHLH, EYA1, HOXB1, PSEN1, SIX1, PDGFRB, TFAP2A, ROR2,
FOXC2, COL1A1, BMPR1B
GO:0007178~transmembrane receptor 1.35E-15 NOG, FST, TGFB3, TGFB1, TGFB2, MAP3K7, FOS, ACVR1B, BMP4, BMP2, NLK, SMAD5, TGFBR2, 481 103 13528 7.372505 5.18E-12 3.18E-14 2.46E-12 protein serine/threonine kinase signaling SMAD4, SMAD3, SMAD2, SMAD1, ACVR2A, ARRB2, ID1, JUN, HIPK2, SPTBN1, BMPR1B, ENG, pathway CHRD, ACVR1
GO:0007548~sex differentiation 1.37E-15 STAT5A, LEPR, STAT5B, FST, TP63, SOX9, WT1, CCNE1, CHD7, BCL2, MKKS, NKX2-1, NOS3, 481 151 13528 5.96021 5.18E-12 3.15E-14 2.46E-12 FANCA, BMP4, AR, TAF4, SMAD5, BRCA2, MMP14, SIRT1, KDR, ACVR2A, CCND1, PLA2G4A,
BAX, VEGFA, ROR2, PBX1, FOXC1, BMPR1B, NR5A1
GO:0043583~ear development 1.64E-15 NOG, TGFB3, FGF10, COL2A1, PAX2, TGFB1, HOXA1, BDNF, HOXA2, CHD7, BCL2, GBX2, 481 95 13528 7.697297 6.47E-12 3.92E-14 3.09E-12
NKX3-2, GFI1, MYC, GSC, MYO6, MAFB, HES1, EYA1, CDKN1B, HES5, DLX6, DLX5, SIX1,
FOXG1
GO:0006915~apoptosis 1.97E-15 E2F1, MEF2C, HRAS, TP63, FASLG, NFKB1, PAX3, DAXX, PDCD4, PTEN, AKT1, CDKN2A, 481 602 13528 3.036724 7.77E-12 4.67E-14 3.70E-12
HTRA2, CASP9, CXCR4, CASP8, FAS, CASP2, TOP2A, MYC, FGF2, TP53, FADD, STK4, EP300,
PSEN1, JUN, HIPK2, PSEN2, RIPK3, MAPK8, NGFR, MAPK7, TNFAIP3, EIF2AK3, BID, TNF,
ERBB3, AKAP13
GO:0031401~positive regulation of 2.50E-15 CAV1, TNF, TGFB3, KITLG, TLR4, TGFB1, MEN1, EDNRB, NOD2, INS, BCL2, FBXO5, FGF2, INSR, 481 187 13528 5.263989 9.93E-12 5.94E-14 4.73E-12 protein modification process AXIN1, GHR, SYK, BMP4, CDK1, BMP2, LYN, SMAD4, IGF1, IGF2, FOXP3, PPARGC1A, BRCA1,
HDAC4, ACVR2A, CCND1, PSEN1, ADAM17, DNMT1, JAK2, MTOR, ENG
GO:0048608~reproductive structure 3.80E-15 NOG, LEPR, STAT5A, STAT5B, FST, TP63, SOX9, WT1, CCNE1, BCL2, NKX2-1, MKKS, NOS3, 481 126 13528 6.473154 1.47E-11 8.74E-14 6.99E-12 development FANCA, BMP4, AR, TAF4, BRCA2, MMP14, SIRT1, KDR, ACVR2A, CCND1, PLA2G4A, BAX,
VEGFA, FOXC1, BMPR1B, NR5A1
GO:0043523~regulation of neuron 4.53E-15 HRAS, TNF, ERBB3, SNCA, TGFB3, TGFB2, BDNF, CASP9, BCL2, ILK, RASA1, GHR, HTT, GRIN1, 481 90 13528 7.812428 1.77E-11 1.05E-13 8.44E-12 apoptosis TP53, ESR1, ESR2, TP73, ATP7A, PSEN1, BAX, JUN, HIPK2, JAK2, F2R
GO:0045137~development of primary 4.71E-15 LEPR, STAT5A, STAT5B, FST, TP63, SOX9, WT1, CCNE1, CHD7, BCL2, NKX2-1, MKKS, NOS3, 481 127 13528 6.422185 1.81E-11 1.07E-13 8.64E-12 sexual characteristics FANCA, BMP4, AR, TAF4, BRCA2, MMP14, SIRT1, KDR, ACVR2A, CCND1, PLA2G4A, BAX,
VEGFA, FOXC1, BMPR1B, NR5A1
GO:0030324~lung development 4.80E-15 WNT5A, FOXA2, TGFB3, FGF10, GLI2, GLI3, ADA, ALDH1A2, CTGF, NKX2-1, NOS3, HHIP, FGF2, 481 99 13528 7.386295 1.86E-11 1.08E-13 8.85E-12
BMP4, TGFBR2, SMAD2, MMP14, FOXP2, KDR, ATP7A, PTHLH, HES1, NOTCH1, EP300, PSEN2,
VEGFA
GO:0016477~cell migration 4.87E-15 TNF, DRD2, PAX6, PRKDC, KITLG, PAX3, KIT, SRF, PTEN, TGFB1, SRC, TGFB2, EDNRB, PTK2, 481 276 13528 4.279852 1.90E-11 1.10E-13 9.05E-12
GAB2, CD44, CXCR4, CTGF, GBX2, NKX2-1, NOS3, PAFAH1B1, FGF2, SYK, APC, SELP, RET,
EFNB1, MET, ESR2, MMP14, KDR, PSEN1, ID1, BAX, SIX1, ADAM17, PDGFRB, FOXC1, ENG, PLAU, A
GO:0002009~morphogenesis of an 7.98E-15 BBS4, TP63, PAX3, PAX2, GLI2, GLI3, MAP3K7, ALDH1A2, CD44, BCL2, CASP8, ILK, MKKS, 481 101 13528 7.240032 3.11E-11 1.80E-13 1.48E-11 epithelium CHUK, BMP4, RET, BMP2, HTT, SMAD4, EYA1, TSC1, TSC2, SIX1, TFAP2A, PBX1, APAF1
GO:0021700~developmental maturation 7.98E-15 MAEA, ERBB4, PPARG, PTH1R, CBFB, TGFB2, BTK, AKT1, CD44, FBXO5, RUNX2, RUNX3, 481 101 13528 7.240032 3.11E-11 1.80E-13 1.48E-11
ERCC2, AXIN1, RET, GRIN1, BRCA2, KDR, CDKN1C, HES1, NOTCH1, PSEN1, HES5, PSEN2,
VEGFA, GDF11
GO:0008361~regulation of cell size 8.43E-15 FGFR2, FGFR1, PPARG, TGFB3, TP63, SFN, TGFB1, TGFB2, AKT1, ACVR1B, CDKN2A, INS, 481 206 13528 4.915003 3.28E-11 1.89E-13 1.56E-11
CDKN2C, CDKN2D, BCL2, ILK, NRG1, FGF2, SPP1, AR, RARG, SPHK1, TP53, SMAD4, SMAD3,
IGF2, RB1, ESR2, TP73, CDKN1A, EP300, CDKN1B, TSC1, TSC2, ADAM17, MTOR, XRN2
GO:0021915~neural tube development 9.19E-15 BMP4, BBS4, GSC, FOXA2, PAX6, PAX3, GLI2, GLI3, HES1, MAP3K7, ALDH1A2, PSEN1, TSC1, 481 68 13528 9.099181 3.58E-11 2.05E-13 1.71E-11
PAX7, TSC2, PSEN2, CASP8, GBX2, MNX1, TFAP2A, APAF1, CHRD
GO:0030323~respiratory tube 1.03E-14 WNT5A, FOXA2, TGFB3, FGF10, GLI2, GLI3, ADA, ALDH1A2, CTGF, NKX2-1, NOS3, HHIP, FGF2, 481 102 13528 7.169051 4.01E-11 2.28E-13 1.91E-11 development BMP4, TGFBR2, SMAD2, MMP14, FOXP2, KDR, ATP7A, PTHLH, HES1, NOTCH1, EP300, PSEN2,
VEGFA
GO:0000904~cell morphogenesis involved 1.09E-14 NOG, ERBB3, DRD2, ERBB2, PAX6, PAX2, SOX9, GLI2, TGFB1, EPHB2, TGFB2, IGF1R, HOXA1, 481 244 13528 4.495348 4.23E-11 2.39E-13 2.02E-11 in differentiation HOXA2, BDNF, PTK2, CXCR4, BCL2, ILK, GBX2, NKX2-1, PAFAH1B1, SNAP25, ETV4, RUNX3,
APC, BMP2, EGR2, RXRA, EFNB1, LEF1, HES1, NOTCH1, DLX5, FOXG1, EFNA5, JAK2, NGFR,
BMPR1B
GO:0007049~cell cycle 1.10E-14 E2F1, NBN, MAEA, CCNT1, DAXX, LATS2, TGFB1, TGFB2, AKT1, MEN1, ACVR1B, CCNE1, 481 776 13528 2.681998 4.27E-11 2.40E-13 2.04E-11
CDKN2A, CDKN2C, CDKN2D, ILK, H2AFX, FANCA, CDCA5, CCNA2, MYC, EGFR, CDC7, CDK1,
RBL2, RBL1, CCNF, TPX2, TP53, CDK6, RB1, MCM2, RAD50, CDK2, MAPK1, HHEX, CCND1,
EP300, ADAM17, MA
GO:0000079~regulation of 1.15E-14 EGFR, GTPBP4, BLM, CCNT1, SFN, CDC25C, PTEN, LATS2, CDC25A, CDKN1C, AKT1, MEN1, 481 54 13528 10.41657 4.49E-11 2.51E-13 2.14E-11 cyclin-dependent protein kinase activity CCND1, CDKN1A, CDKN2A, CDKN1B, CDKN2C, CDKN2D, ADAM17, APC
GO:0019216~regulation of lipid metabolic 1.22E-14 BBS4, CAV1, TNF, THRB, STK11, STAT5A, PPARG, SNCA, STAT5B, NFKB1, TGFB1, NR1H2, 481 112 13528 6.780071 4.75E-11 2.64E-13 2.26E-11 process AKT1, APOE, INS, GFI1, AKT2, RBL2, RBL1, PRKAB1, IGF2, RB1, PPARGC1A, IRS1, BRCA1, PLA2G4A, MTOR, NR5A1
GO:0008406~gonad development 1.22E-14 LEPR, STAT5A, STAT5B, FST, SOX9, WT1, CCNE1, BCL2, NKX2-1, MKKS, NOS3, FANCA, BMP4, 481 112 13528 6.780071 4.75E-11 2.64E-13 2.26E-11
AR, TAF4, BRCA2, MMP14, SIRT1, KDR, ACVR2A, CCND1, PLA2G4A, BAX, VEGFA, FOXC1,
BMPR1B, NR5A1
GO:0035270~endocrine system 1.28E-14 BMP4, FOXA2, DRD2, SLC6A3, PAX6, GLI2, CITED2, HES1, HHEX, ALDH1A2, EYA1, CRKL, 481 69 13528 8.967308 5.01E-11 2.77E-13 2.39E-11 development PAX8, SIX1, MNX1, NKX2-1, NEUROD1, PBX1, NKX2-5, EIF2AK3, PITX1, NR5A1
GO:0032496~response to 1.31E-14 SELP, STAT5B, SNCA, SOCS1, FASLG, TLR4, STAT1, GCH1, MAPK1, FOS, TNFRSF1A, NOD2, 481 77 13528 8.400896 5.09E-11 2.80E-13 2.43E-11 lipopolysaccharide PLA2G4A, MYD88, THBD, HSF1, MAPK14, JUN, PLCG2, NKX2-1, ADAM17, NOS3, F2R
GO:0010551~regulation of specific 1.32E-14 MEF2C, FOXA2, PPARG, PRKDC, NFKB1, SRF, CITED2, NR1H2, VDR, TAL1, GFI1, NKX2-5, 481 94 13528 7.479984 5.14E-11 2.81E-13 2.45E-11 transcription from RNA polymerase II RXRA, TP53, SMAD3, FOXP3, SIRT1, HES1, HHEX, HDAC4, NOTCH1, HES5, ETS1, TBL1X, ENG promoter
GO:0022602~ovulation cycle process 1.57E-14 BMP4, TAF4, STAT5A, LEPR, ERBB2, STAT5B, TGFB3, MMP14, SIRT1, TGFB2, KDR, CCNE1, 481 62 13528 9.526122 6.08E-11 3.31E-13 2.90E-11
PLA2G4A, BAX, BCL2, VEGFA, NKX2-1, NOS3, FOXC1, BMPR1B, NR5A1
GO:0030879~mammary gland 2.22E-14 CAV1, ELF3, ERBB4, ERBB3, STAT5A, ERBB2, SLC6A3, STAT5B, MET, TGFB3, LEF1, IGF1, 481 63 13528 9.374913 8.63E-11 4.67E-13 4.11E-11 development BRCA2, GLI2, GLI3, IRS1, TGFB1, PTHLH, IGF1R, PRLR, NRG1
GO:0000082~G1/S transition of mitotic 2.50E-14 EGFR, CDC7, RB1, LATS2, CDC25A, AKT1, CCNE1, ACVR1B, CCND1, CDKN1A, CDKN2A, 481 56 13528 10.04455 9.71E-11 5.22E-13 4.63E-11 cell cycle CDKN1B, CDKN2C, BCL2, CDKN2D, NPAT, ADAM17, GFI1, CDCA5, ACVR1
GO:0001525~angiogenesis 4.02E-14 IL18, LEPR, FGF10, SRF, PTEN, TGFB2, MAP3K7, PTK2, CXCR4, CTGF, CASP8, GBX2, TGFA, 481 148 13528 5.700961 1.56E-10 8.35E-13 7.45E-11
NOS3, FGF2, BMP4, KLF5, TGFBR2, MMP14, KDR, NOTCH1, MEOX2, ID1, MAPK14, JUN, VEGFA,
FOXC2, ENG, PLAU, ACVR1
GO:0051674~localization of cell 4.19E-14 TNF, DRD2, PAX6, PRKDC, KITLG, PAX3, KIT, SRF, PTEN, TGFB1, SRC, TGFB2, EDNRB, PTK2, 481 307 13528 3.939296 1.63E-10 8.65E-13 7.75E-11
GAB2, CD44, CXCR4, CTGF, GBX2, NKX2-1, NOS3, PAFAH1B1, FGF2, SYK, APC, SELP, RET,
EFNB1, MET, ESR2, MMP14, KDR, PSEN1, ID1, ETS1, BAX, SIX1, ADAM17, PDGFRB, FOXC1,
ENG, P
GO:0048870~cell motility 4.19E-14 TNF, DRD2, PAX6, PRKDC, KITLG, PAX3, KIT, SRF, PTEN, TGFB1, SRC, TGFB2, EDNRB, PTK2, 481 307 13528 3.939296 1.63E-10 8.65E-13 7.75E-11
GAB2, CD44, CXCR4, CTGF, GBX2, NKX2-1, NOS3, PAFAH1B1, FGF2, SYK, APC, SELP, RET, EFNB1, MET, ESR2, MMP14, KDR, PSEN1, ID1, ETS1, BAX, SIX1, ADAM17, PDGFRB, FOXC1,
ENG, P
GO:0048511~rhythmic process 4.66E-14 ERBB3, DRD2, ERBB2, LEPR, STAT5A, STAT5B, TGFB3, ADA, TGFB2, CCNE1, BCL2, NKX2-1, 481 128 13528 6.152287 1.81E-10 9.59E-13 8.64E-11
NOS3, EGFR, BMP4, BMP2, TAF4, EGR2, MMP14, SIRT1, KDR, PLA2G4A, JUN, BAX, VEGFA,
FOXC1, BMPR1B, NR5A1
GO:0031175~neuron projection 5.26E-14 BBS4, FGFR1, ERBB3, DRD2, ERBB2, PAX6, PAX2, GLI2, PTEN, EPHB2, IGF1R, HOXA1, HOXA2, 481 256 13528 4.284628 2.05E-10 1.08E-12 9.75E-11 development BDNF, PTK2, CD44, CXCR4, BCL2, ILK, GBX2, NKX2-1, PAFAH1B1, SNAP25, ETV4, RUNX3, APC,
EGFR, MYO6, EGR2, RXRA, EFNB1, ATP7A, NOTCH1, DLX5, FOXG1, EFNA5, JAK2, NGFR,
BMPR1B
GO:0043408~regulation of MAPKKK 5.36E-14 CAV1, TNF, ERBB2, LEPR, MAP4K1, TLR4, PDCD4, DAXX, TGFB2, MEN1, AKT1, MAP3K7, NOD2, 481 109 13528 6.708654 2.08E-10 1.09E-12 9.93E-11 cascade INS, ILK, INSR, APC, AKT2, SYK, AXIN1, PTPRC, NF2, IGF2, TP73, HIPK2, F2R, CBS
GO:0040007~growth 5.40E-14 FGFR2, FGFR1, NBN, TGFB3, FGF10, GLI2, GLI3, TGFB1, TGFB2, AKT1, CCNE1, BCL2, PAX7, 481 183 13528 5.071674 2.10E-10 1.09E-12 1.00E-10
ERCC2, BMP4, BMP2, AR, RXRA, BRCA2, IGF1, SMAD2, FOXP2, PRKCQ, NOTCH1, PSEN1,
PSEN2, GDF11, FOXC2, FOXC1, MTOR, BMPR1B, PLAU, XRN2
GO:0048762~mesenchymal cell 5.48E-14 RET, NOG, BMP2, EFNB1, LEF1, KITLG, PAX3, SOX9, TGFB1, TGFB2, EDNRB, ALDH1A2, 481 51 13528 10.47784 2.13E-10 1.10E-12 1.01E-10 differentiation NOTCH1, BCL2, GBX2, FOXC2, FOXC1, NRG1, ACVR1
GO:0014031~mesenchymal cell 5.48E-14 RET, NOG, BMP2, EFNB1, LEF1, KITLG, PAX3, SOX9, TGFB1, TGFB2, EDNRB, ALDH1A2, 481 51 13528 10.47784 2.13E-10 1.10E-12 1.01E-10 development NOTCH1, BCL2, GBX2, FOXC2, FOXC1, NRG1, ACVR1
GO:0022402~cell cycle process 6.09E-14 E2F1, NBN, DAXX, LATS2, TGFB1, TGFB2, AKT1, MEN1, ACVR1B, CCNE1, CDKN2A, CDKN2C, 481 565 13528 2.986698 2.36E-10 1.22E-12 1.13E-10
CDKN2D, ILK, H2AFX, CDCA5, CCNA2, MYC, FANCA, EGFR, CDC7, CDK1, CCNF, TPX2, TP53,
CDK6, RB1, RAD50, CDK2, CCND1, ADAM17, ACVR1, BBS4, BLM, STK11, NEK1, NIPBL, BCL2,
NPAT, FBX
GO:0007584~response to nutrient 6.49E-14 CAV1, PPARG, PTEN, TGFB1, AQP3, CCNE1, VDR, ALDH1A2, CD44, BCL2, CDKN2D, RARA, 481 140 13528 5.825839 2.52E-10 1.29E-12 1.20E-10
OGT, INSR, SPP1, BMP4, BMP2, RARG, RXRA, TGFBR2, CSNK2B, BRCA2, STAT1, CCND1,
PLA2G4A, COL1A1, ALOX5, MTOR, LRP2
GO:0030030~cell projection organization 7.27E-14 BBS4, FGFR1, DRD2, ERBB3, ERBB2, ITGB4, PAX6, PAX2, GLI2, PTEN, VCL, EPHB2, AKT1, 481 368 13528 3.592018 2.82E-10 1.44E-12 1.35E-10 IGF1R, HOXA1, HOXA2, BDNF, PTK2, CD44, CXCR4, BCL2, ILK, GBX2, MKKS, NKX2-1,
PAFAH1B1, SNAP25, ETV4, RUNX3, APC, EGFR, KLF5, MYO6, EGR2, RXRA, EFNB1, ATP7A,
NOTCH1, TSC1, DL
GO:0009968~negative regulation of signal 7.57E-14 NOG, CAV1, ERBB3, DRD2, TGFB3, PTEN, ADA, MEN1, AKT1, NOD2, INPP5D, HHIP, RUNX2, 481 221 13528 4.581406 2.94E-10 1.49E-12 1.40E-10 transduction AXIN1, APC, PTPRC, GSC, NF2, NLK, SOCS1, DLL3, SIRT1, PRKCD, IRS1, CTNNBIP1, HHEX,
CCND1, TSC1, ATXN7, HIPK2, TSC2, NGFR, TNFAIP3, CHRD, ENG, ACVR1
GO:0060485~mesenchyme development 8.11E-14 RET, NOG, BMP2, EFNB1, LEF1, KITLG, PAX3, SOX9, TGFB1, TGFB2, EDNRB, ALDH1A2, 481 52 13528 10.27635 3.15E-10 1.59E-12 1.50E-10
NOTCH1, BCL2, GBX2, FOXC2, FOXC1, NRG1, ACVR1
GO:0000902~cell morphogenesis 9.19E-14 BBS4, NOG, DRD2, ERBB3, ERBB2, PAX6, PAX2, SOX9, GLI2, TGFB1, TGFB2, EPHB2, IGF1R, 481 356 13528 3.634096 3.57E-10 1.80E-12 1.70E-10
HOXA1, HOXA2, BDNF, PTK2, CXCR4, COL4A3BP, BCL2, ILK, GBX2, MKKS, NKX2-1,
PAFAH1B1, SNAP25, ETV4, RUNX3, APC, DLG1, EGFR, BMP2, EGR2, RXRA, EFNB1, LEF1, STK4,
HES1, ATP7A,
GO:0010648~negative regulation of cell 9.74E-14 NOG, CAV1, ACHE, ERBB3, DRD2, TGFB3, PTEN, ADA, MEN1, AKT1, NOD2, INPP5D, HHIP, 481 248 13528 4.309436 3.79E-10 1.89E-12 1.81E-10 communication RUNX2, AXIN1, APC, PTPRC, GSC, NF2, NLK, SOCS1, DLL3, SIRT1, PRKCD, IRS1, CTNNBIP1,
HHEX, CCND1, TSC1, ATXN7, HIPK2, TSC2, MTOR, NGFR, TNFAIP3, CHRD, ENG, ACVR1
GO:0051050~positive regulation of 9.96E-14 CAV1, ACHE, TNF, ERBB4, DRD2, ERBB3, SNCA, TGFB3, IL13, FGF10, GLI3, TGFB1, TGFB2, 481 223 13528 4.540317 3.87E-10 1.93E-12 1.84E-10 transport NR1H2, AKT1, NOD2, INS, APOE, PRKACA, NKX2-5, SNAP25, INSR, HIP1, SYK, AKT2, BMP4,
CBL, SMAD4, SMAD3, IGF2, IRS1, PRKCQ, PLA2G4A, BAX, PLCG2, JAK2, F2R
GO:0043434~response to peptide hormone 1.18E-13 ERBB3, GRB2, STAT5A, PPARG, STAT5B, PRKDC, AKT1, IGF1R, PDPK1, INS, BCL2, NOS3, 481 154 13528 5.478845 4.58E-10 2.27E-12 2.18E-10 stimulus CCNA2, INSR, GHR, AKT2, AR, EGR2, LYN, RXRA, SOCS1, IGF2, STAT1, IRS1, STAT3, PRKCQ,
TSC1, FOXC2, JAK2, MTOR, COL1A1
GO:0030098~lymphocyte differentiation 1.19E-13 BLM, STAT5A, STAT5B, RAG1, SOX4, PRKDC, RAG2, ADA, TGFB1, CBFB, CHD7, BCL2, ZAP70, 481 103 13528 6.826393 4.62E-10 2.28E-12 2.20E-10
FAS, SYK, APC, EGR1, PTPRC, TP53, ATP7A, HDAC4, BAX, PLCG2, ADAM17, TSHR
GO:0010720~positive regulation of cell 1.56E-13 XRCC5, BMP2, LYN, DRD2, PPARG, TGFB3, DLL3, SMAD4, PAX6, SMAD3, SMAD2, KIT, SMAD1, 481 69 13528 8.559704 6.07E-10 2.97E-12 2.89E-10 development TGFB1, TGFB2, EPHB2, NOTCH1, BCL2, ILK, FOXG1, NGFR
GO:0051052~regulation of DNA 1.61E-13 HRAS, NBN, BLM, HUS1, TGFB3, KITLG, GLI2, TGFB1, STAT6, IGF1R, INS, H2AFX, INSR, MYC, 481 114 13528 6.414414 6.26E-10 3.05E-12 2.98E-10 metabolic process PTPRC, GTPBP4, NF2, TP53, BRCA2, IGF1, IGF2, ATR, RAD50, CDK2, BRCA1, EYA1, JUN
GO:0002237~response to molecule of 1.62E-13 SELP, STAT5B, SNCA, SOCS1, FASLG, TLR4, STAT1, GCH1, MAPK1, FOS, TNFRSF1A, NOD2, 481 86 13528 7.521733 6.29E-10 3.05E-12 3.00E-10 bacterial origin PLA2G4A, MYD88, THBD, HSF1, MAPK14, JUN, PLCG2, NKX2-1, ADAM17, NOS3, F2R
GO:0007369~gastrulation 2.12E-13 BMP4, BBS4, TBX6, GSC, NF2, FOXA2, HTT, TP53, SMAD4, SMAD3, LEF1, SMAD2, SMAD1, 481 70 13528 8.437422 8.23E-10 3.97E-12 3.92E-10
ACVR2A, GATA4, MKKS, FOXC2, PRKACA, FOXC1, CHRD, ACVR1
GO:0045637~regulation of myeloid cell 2.12E-13 TNF, MAFB, STAT5A, CSF1, STAT5B, SPI1, KITLG, CDK6, TLR4, RB1, ARNT, ACVR1B, TAL1, 481 70 13528 8.437422 8.23E-10 3.97E-12 3.92E-10 differentiation ACVR2A, ETS1, MAPK14, JUN, FAS, INPP5D, RUNX1, APC
GO:0032990~cell part morphogenesis 2.66E-13 BBS4, ERBB3, DRD2, ERBB2, PAX6, PAX2, GLI2, EPHB2, IGF1R, HOXA1, HOXA2, BDNF, PTK2, 481 256 13528 4.174766 1.03E-09 4.98E-12 4.93E-10
CXCR4, COL4A3BP, BCL2, ILK, GBX2, MKKS, NKX2-1, PAFAH1B1, SNAP25, ETV4, RUNX3, APC,
EGFR, EGR2, RXRA, EFNB1, ATP7A, NOTCH1, DLX5, BAX, FOXG1, EFNA5, JAK2, NGFR,
BMPR1B
GO:0033674~positive regulation of kinase 2.92E-13 TNF, ERBB2, CSF1, TGFB3, KITLG, MAP4K1, KIT, DAXX, TGFB1, TGFB2, MAP3K7, AKT1, 481 231 13528 4.383076 1.13E-09 5.43E-12 5.41E-10 activity PDPK1, CXCR4, INS, ILK, TGFA, PRKACA, CERK, NRG1, FGF2, INSR, GHR, SYK, EGFR, PTPRC,
SPHK1, MET, TGFBR2, IGF2, IRS1, CCND1, PRLR, PSEN1, ADAM17, JAK2, F2R
GO:0032989~cellular component 2.95E-13 BBS4, NOG, DRD2, ERBB3, ERBB2, PAX6, PAX2, SOX9, GLI2, TGFB1, TGFB2, EPHB2, IGF1R, 481 397 13528 3.400472 1.15E-09 5.47E-12 5.47E-10 morphogenesis HOXA1, HOXA2, BDNF, PTK2, CXCR4, COL4A3BP, BCL2, ILK, GBX2, MKKS, NKX2-1,
PAFAH1B1, SNAP25, ETV4, RUNX3, APC, DLG1, ERCC2, EGFR, BMP2, EGR2, RXRA, EFNB1,
LEF1, STK4, HES1,
GO:0045927~positive regulation of 3.34E-13 DRD2, STAT5A, CSF1, SLC6A3, SPHK1, TGFBR2, STAT5B, IGF2, SFN, RAG2, TGFB2, AKT1, 481 80 13528 7.734304 1.30E-09 6.15E-12 6.18E-10 growth EP300, CHD7, HSF1, INS, BCL2, ILK, ADAM17, NRG1, INSR, TSHR, GHR
GO:0000165~MAPKKK cascade 3.83E-13 WNT5A, FGFR1, CAV1, TNF, GRB2, TGFB3, MAP4K1, DAXX, MEN1, MAP3K7, CXCR4, INS, 481 184 13528 4.891259 1.49E-09 7.02E-12 7.10E-10
TGFA, MAP2K7, FGF2, INSR, GHR, SYK, EGFR, PTPRC, RET, MET, IGF2, SMAD1, MAPK1, CRKL,
PSEN1, MAPK9, ROR2, MAPK8, JAK2, MAPK7, F2R
GO:0008585~female gonad development 3.94E-13 BMP4, TAF4, STAT5A, LEPR, STAT5B, FST, BRCA2, MMP14, SIRT1, KDR, CCNE1, PLA2G4A, 481 64 13528 8.788981 1.53E-09 7.19E-12 7.30E-10
BAX, BCL2, VEGFA, NOS3, FOXC1, BMPR1B, FANCA, NR5A1
GO:0048585~negative regulation of 5.23E-13 DRD2, SLC6A3, PPARG, TGFB1, ADA, TGFB2, STAT6, MEN1, AKT1, TNFRSF1B, APOE, INS, 481 100 13528 6.749938 2.03E-09 9.50E-12 9.69E-10 response to stimulus INPP5D, SPP1, PTPRC, IL2RA, SOCS1, GRIN1, IGF2, ESR2, FOXP3, IRS1, PRKCD, SIRT1, MTOR
GO:0045860~positive regulation of 5.36E-13 TNF, ERBB2, CSF1, TGFB3, KITLG, MAP4K1, KIT, DAXX, TGFB1, TGFB2, MAP3K7, AKT1, 481 223 13528 4.414197 2.08E-09 9.69E-12 9.93E-10 protein kinase activity PDPK1, CXCR4, INS, ILK, TGFA, PRKACA, CERK, NRG1, FGF2, INSR, GHR, SYK, EGFR, PTPRC,
SPHK1, MET, TGFBR2, IGF2, CCND1, PRLR, PSEN1, ADAM17, JAK2, F2R
GO:0043086~negative regulation of 6.65E-13 CAV1, DRD2, LEPR, PPARG, SNCA, RAG1, NFKB1, SFN, PDCD4, LATS2, TGFB2, MEN1, AKT1, 481 277 13528 3.959801 2.58E-09 1.20E-11 1.23E-09 catalytic activity EDNRB, PDPK1, CDKN2A, INS, APOE, CDKN2D, ILK, FBXO5, NOS3, GFI1, APC, PTPRC, NF2,
TP53, IGF2, BIRC5, RB1, SIRT1, TP73, CDKN1C, ATP7A, CDKN1A, CDKN1B, PSEN1, TSC2, ENG,
HDAC6
GO:0009314~response to radiation 6.87E-13 CAV1, HRAS, BLM, DRD2, NEK1, HUS1, PRKDC, KIT, TGFB1, MEN1, AKT1, FOS, CASP9, 481 200 13528 4.640582 2.67E-09 1.23E-11 1.27E-09
CDKN2D, BCL2, H2AFX, MYC, ERCC2, EGFR, PTPRC, HTT, GRIN1, TP53, BRCA2, MBD4, BRCA1,
CDKN1A, CCND1, EYA1, THBD, BAX, MAPK8, LRP2
GO:0048812~neuron projection 7.52E-13 ERBB3, DRD2, ERBB2, PAX6, PAX2, GLI2, EPHB2, IGF1R, HOXA1, HOXA2, PTK2, BDNF, CXCR4, 481 213 13528 4.489395 2.92E-09 1.34E-11 1.39E-09 morphogenesis BCL2, ILK, GBX2, NKX2-1, PAFAH1B1, SNAP25, ETV4, RUNX3, APC, EGFR, EGR2, RXRA,
EFNB1, ATP7A, NOTCH1, DLX5, FOXG1, EFNA5, JAK2, NGFR, BMPR1B
GO:0007610~behavior 7.53E-13 HRAS, IL18, SLC6A3, LEPR, SNCA, FGF10, CXCR3, PTEN, TGFB2, FOS, EDNRB, BDNF, HTRA2, 481 469 13528 3.118308 2.93E-09 1.34E-11 1.40E-09
CXCR4, MKKS, FGF2, SYK, EGR1, EGR2, MYO6, CCKBR, ESR2, MAPK1, PSEN1, JUN, HIPK2,
PSEN2, PDGFRB, TSHR, BBS4, DRD2, KIT, ADA, EPHB2, CHD7, BCL2, NKX2-1, PAFAH1B1, GFI1,
SNAP
GO:0006351~transcription, 7.75E-13 TAF1C, THRB, ELF3, FOXM1, CCNT1, TCOF1, NFKB1, TBP, PAX3, PAX2, CBFB, ARNT, TROVE2, 481 292 13528 3.852704 3.01E-09 1.37E-11 1.44E-09
DNA-dependent CDKN2A, GATA3, GATA4, NKX3-2, NFATC4, NFATC3, APEX1, MYC, RUNX3, ERCC2, KLF5,
TAF4, AR, CEBPB, MLL, TAF5, ESR1, TP53, CDK9, POLR1C, STAT1, PPARGC1A, TTF2, ETS1,
XRN2, MED1
GO:0051347~positive regulation of 9.20E-13 TNF, ERBB2, CSF1, TGFB3, KITLG, MAP4K1, KIT, DAXX, TGFB1, TGFB2, MAP3K7, AKT1, 481 240 13528 4.218711 3.58E-09 1.62E-11 1.70E-09 transferase activity PDPK1, CXCR4, INS, ILK, TGFA, PRKACA, CERK, NRG1, FGF2, INSR, GHR, SYK, EGFR, PTPRC,
SPHK1, MET, TGFBR2, IGF2, IRS1, CCND1, PRLR, PSEN1, ADAM17, JAK2, F2R
GO:0060562~epithelial tube 9.89E-13 BMP4, BBS4, RET, BMP2, SMAD4, PAX3, PAX2, GLI3, MAP3K7, EYA1, CD44, TSC1, BCL2, ILK, 481 67 13528 8.395445 3.84E-09 1.73E-11 1.83E-09 morphogenesis TSC2, SIX1, CASP8, TFAP2A, PBX1, APAF1
GO:0006461~protein complex assembly 1.07E-12 XPO1, HRAS, TP63, TBP, TGFB1, RANBP9, NOD2, ILK, CASP8, FAS, NRG1, MDN1, MYC, INSR, 481 505 13528 3.007398 4.15E-09 1.86E-11 1.98E-09
FANCA, SYK, IKBKAP, PRKAB1, TP53, CDK9, FADD, WAS, IRS1, PPARGC1A, JUP, WASL, PRNP,
EIF2AK3, MED1, CAV1, BLM, GRB2, SRC, GCH1, IGF1R, TNFRSF1A, PTK2, FBXO5, APC, HIP1,
ERC
GO:0070271~protein complex biogenesis 1.07E-12 XPO1, HRAS, TP63, TBP, TGFB1, RANBP9, NOD2, ILK, CASP8, FAS, NRG1, MDN1, MYC, INSR, 481 505 13528 3.007398 4.15E-09 1.86E-11 1.98E-09
FANCA, SYK, IKBKAP, PRKAB1, TP53, CDK9, FADD, WAS, IRS1, PPARGC1A, JUP, WASL, PRNP,
EIF2AK3, MED1, CAV1, BLM, GRB2, SRC, GCH1, IGF1R, TNFRSF1A, PTK2, FBXO5, APC, HIP1,
ERC
GO:0042493~response to drug 1.12E-12 NBN, CAV1, ERBB4, ERBB3, DRD2, SLC6A3, ERBB2, SNCA, PPARG, PTEN, TGFB1, CCNE1, FOS, 481 216 13528 4.427042 4.37E-09 1.95E-11 2.08E-09
BDNF, BCL2, NOS3, APC, LYN, SOCS1, TGFBR2, TP53, SMAD1, STAT1, STAT3, HDAC4, CDKN1A,
CCND1, EP300, JUN, ADAM17, NEUROD1, LRP2, IKBKB, LIPE
GO:0032774~RNA biosynthetic process 1.20E-12 TAF1C, THRB, ELF3, FOXM1, CCNT1, TCOF1, NFKB1, TBP, PAX3, PAX2, CBFB, ARNT, TROVE2, 481 296 13528 3.800641 4.67E-09 2.07E-11 2.22E-09
CDKN2A, GATA3, GATA4, NKX3-2, NFATC4, NFATC3, APEX1, MYC, RUNX3, ERCC2, KLF5,
TAF4, AR, CEBPB, MLL, TAF5, ESR1, TP53, CDK9, POLR1C, STAT1, PPARGC1A, TTF2, ETS1,
XRN2, MED1
GO:0009953~dorsal/ventral pattern 1.35E-12 BMP4, NOG, GSC, FOXA2, PAX6, SMAD2, GLI2, GLI3, HOXA2, PSEN1, PAX7, PSEN2, FOXG1, 481 60 13528 8.906168 5.25E-09 2.32E-11 2.50E-09 formation MNX1, NKX2-1, HHIP, BMPR1B, CHRD, APC
GO:0001952~regulation of cell-matrix 1.53E-12 NF2, CSF1, MYF5, SMAD3, CDK6, MMP14, PTEN, CD36, CDKN2A, TSC1, BCL2, TSC2, ILK, RASA1 481 27 13528 14.5832 5.96E-09 2.63E-11 2.84E-09 adhesion
GO:0032535~regulation of cellular 1.57E-12 FGFR2, FGFR1, PPARG, TGFB3, TP63, SFN, TGFB1, TGFB2, AKT1, ACVR1B, CDKN2A, INS, 481 271 13528 3.94369 6.10E-09 2.67E-11 2.91E-09 component size CDKN2C, CDKN2D, BCL2, ILK, NRG1, FGF2, RASA1, SPP1, AR, RARG, SPHK1, TP53, SMAD4,
SMAD3, IGF2, RB1, ESR2, TP73, CDKN1A, EP300, CDKN1B, TSC1, TSC2, SPTBN1, ADAM17,
MTOR, XRN2
GO:0001558~regulation of cell growth 1.65E-12 FOXM1, PPARG, TP63, SFN, TGFB1, TGFB2, AKT1, ACVR1B, CDKN2A, CD44, CTGF, INS, APOE, 481 194 13528 4.639132 6.39E-09 2.79E-11 3.05E-09
CDKN2C, CDKN2D, BCL2, ILK, NRG1, FGF2, SPP1, SPHK1, SMAD4, TP53, SMAD3, IGF2, RB1, ESR2, TP73, PRKCQ, CDKN1A, CDKN1B, EP300, ADAM17
GO:0048858~cell projection 1.70E-12 BBS4, ERBB3, DRD2, ERBB2, PAX6, PAX2, GLI2, EPHB2, IGF1R, HOXA1, HOXA2, PTK2, BDNF, 481 245 13528 4.132615 6.60E-09 2.87E-11 3.15E-09 morphogenesis CXCR4, BCL2, ILK, GBX2, MKKS, NKX2-1, PAFAH1B1, SNAP25, ETV4, RUNX3, APC, EGFR,
EGR2, RXRA, EFNB1, ATP7A, NOTCH1, DLX5, FOXG1, EFNA5, JAK2, NGFR, BMPR1B
GO:0032101~regulation of response to 1.77E-12 CAV1, DRD2, STAT5A, SLC6A3, PPARG, STAT5B, FGF10, TLR4, ADA, TGFB1, TNFRSF1A, 481 159 13528 5.12967 6.88E-09 2.98E-11 3.28E-09 external stimulus TNFRSF1B, APOE, INS, NOS3, SPP1, SELP, IL2RA, GRIN1, TGFBR2, SMAD3, IGF2, KDR,
PLA2G4A, VEGFA, ADAM17, JAK2, MTOR, PLAU, F2R
GO:0042476~odontogenesis 2.37E-12 BMP4, BMP2, ERBB4, NF2, ERBB3, CSF1, FST, TGFB3, LEF1, TP63, GLI2, GLI3, TGFB1, TGFB2, 481 54 13528 9.374913 9.22E-09 3.98E-11 4.40E-09
BAX, FOXC1, COL1A1, CHUK
GO:0006275~regulation of DNA 2.53E-12 HRAS, NBN, GTPBP4, NF2, BLM, HUS1, TP53, TGFB3, IGF1, KITLG, BRCA2, IGF2, ATR, GLI2, 481 62 13528 8.618872 9.83E-09 4.22E-11 4.68E-09 replication TGFB1, CDK2, IGF1R, INS, JUN, INSR
GO:0045646~regulation of erythrocyte 2.55E-12 ACVR2A, TAL1, ACVR1B, ETS1, MAFB, MAPK14, STAT5A, STAT5B, SPI1, CDK6, INPP5D, ARNT 481 18 13528 18.74983 9.91E-09 4.23E-11 4.72E-09 differentiation
GO:0007398~ectoderm development 3.28E-12 LOR, ELF3, FOXA2, FST, PAX6, FGF10, TP63, SFN, SOX9, GLI2, TGFB2, AKT1, ACVR1B, 481 199 13528 4.522571 1.28E-08 5.43E-11 6.08E-09
CDKN2A, CTGF, POU2F3, BCL2, RUNX3, ERCC2, APC, NF2, LEF1, WAS, PTHLH, ATP7A,
NOTCH1, PSEN1, HOXC13, PSEN2, TFAP2A, NGFR, COL1A1
GO:0050865~regulation of cell activation 3.44E-12 BLM, STAT5A, IL18, ERBB2, SNCA, STAT5B, IL13, TLR4, ZEB1, ADA, TGFB1, STAT6, MAP3K7, 481 175 13528 4.821384 1.34E-08 5.67E-11 6.37E-09
CDKN2A, APOE, ZAP70, NOS3, RARA, FAS, INPP5D, SYK, SELP, PTPRC, IL2RA, EFNB1, TGFBR2,
FOXP3, PRKCQ, CDKN1A, JAK2
GO:0045792~negative regulation of cell 3.55E-12 PPARG, TP53, SMAD4, SMAD3, TP63, RB1, ESR2, TGFB1, TP73, TGFB2, AKT1, ACVR1B, 481 99 13528 6.534031 1.38E-08 5.82E-11 6.57E-09 size CDKN1A, CDKN2A, CDKN1B, TSC1, CDKN2C, CDKN2D, BCL2, TSC2, MTOR, FGF2, SPP1
GO:0045786~negative regulation of cell 4.27E-12 EGFR, BMP4, BMP2, TP53, SMAD3, CDK6, RB1, PDCD4, TGFB1, LATS2, MEN1, CDKN1A, 481 81 13528 7.291599 1.66E-08 6.97E-11 7.91E-09 cycle CDKN2A, CDKN1B, ETS1, BCL2, FOXC1, NGFR, RUNX3, APC, DLG1
GO:0014070~response to organic cyclic 4.99E-12 DRD2, SLC6A3, LEPR, PPARG, PTEN, TGFB1, FOS, CCNE1, CD44, BCL2, NOS3, GHR, BMP4, LYN, 481 121 13528 5.810897 1.94E-08 8.12E-11 9.25E-09 substance RXRA, TGFBR2, GRIN1, BRCA2, LEF1, STAT1, STAT3, PRKCQ, CDKN1A, CCND1, JUN
GO:0022403~cell cycle phase 5.14E-12 E2F1, NBN, BLM, NEK1, LATS2, AKT1, CCNE1, ACVR1B, NIPBL, CDKN2A, CDKN2C, CDKN2D, 481 414 13528 3.192905 2.00E-08 8.32E-11 9.52E-09 BCL2, NPAT, FBXO5, PAFAH1B1, H2AFX, GFI1, CCNA2, FANCA, CDCA5, HELLS, APC, CDC7,
EGFR, CDK1, PDS5B, PDS5A, CCNF, TPX2, BRCA2, CDK6, BIRC5, RB1, CDC25C, RAD50,
CDC25A, CDK2, C
GO:0001654~eye development 5.26E-12 BBS4, PAX6, FASLG, ZEB1, PAX2, GLI3, WT1, EPHB2, TGFB2, ALDH1A2, CHD7, POU2F1, RARB, 481 132 13528 5.539722 2.04E-08 8.48E-11 9.74E-09
APC, BMP4, RARG, STAT3, FOXP2, BAX, VEGFA, GDF11, NEUROD1, FOXC2, FOXC1, BMPR1B,
MED1
GO:0001942~hair follicle development 5.85E-12 FST, TP63, SOX9, TGFB2, AKT1, ATP7A, ACVR1B, NOTCH1, PSEN1, HOXC13, BCL2, PSEN2, 481 42 13528 10.71419 2.28E-08 9.40E-11 1.08E-08
NGFR, RUNX3, ERCC2, APC
GO:0022405~hair cycle process 5.85E-12 FST, TP63, SOX9, TGFB2, AKT1, ATP7A, ACVR1B, NOTCH1, PSEN1, HOXC13, BCL2, PSEN2, 481 42 13528 10.71419 2.28E-08 9.40E-11 1.08E-08
NGFR, RUNX3, ERCC2, APC
GO:0022404~molting cycle process 5.85E-12 FST, TP63, SOX9, TGFB2, AKT1, ATP7A, ACVR1B, NOTCH1, PSEN1, HOXC13, BCL2, PSEN2, 481 42 13528 10.71419 2.28E-08 9.40E-11 1.08E-08
NGFR, RUNX3, ERCC2, APC
GO:0030217~T cell differentiation 6.17E-12 EGR1, PTPRC, BLM, STAT5A, STAT5B, RAG1, TP53, PRKDC, SOX4, RAG2, TGFB1, ATP7A, CHD7, 481 65 13528 8.221078 2.40E-08 9.87E-11 1.14E-08
BCL2, ZAP70, ADAM17, FAS, APC, SYK
GO:0045664~regulation of neuron 6.27E-12 NBN, NOG, FOXA2, PAX6, GLI2, EPHB2, PTK2, BDNF, HOXA2, APOE, BCL2, ILK, NKX2-5, SPP1, 481 133 13528 5.498069 2.44E-08 9.98E-11 1.16E-08 differentiation GRIN1, SMAD1, HES1, NOTCH1, EYA1, PSEN1, HES5, SIX1, FOXG1, NEUROD1, PBX1, NGFR
GO:0051216~cartilage development 6.96E-12 WNT5A, BMP4, NOG, BMP2, MYF5, PTH1R, COL2A1, ZEB1, SOX9, ATP7A, CTGF, MAPK14, PAX7, 481 74 13528 7.601281 2.71E-08 1.10E-10 1.29E-08
ROR2, COL1A1, BMPR1B, RUNX2, EIF2AK3, PITX1, GHR
GO:0007498~mesoderm development 6.96E-12 BMP4, TBX6, NF2, HTT, DLL3, SMAD3, LEF1, TP63, SMAD2, SMAD1, BTK, ACVR2A, VEGFA, 481 74 13528 7.601281 2.71E-08 1.10E-10 1.29E-08
GDF11, FOXC2, JAK2, FOXC1, PRKACA, CHRD, ACVR1
GO:0007409~axonogenesis 7.85E-12 ERBB3, DRD2, ERBB2, PAX6, PAX2, GLI2, EPHB2, IGF1R, HOXA1, PTK2, BDNF, HOXA2, CXCR4, 481 193 13528 4.517445 3.05E-08 1.24E-10 1.45E-08
BCL2, GBX2, NKX2-1, PAFAH1B1, SNAP25, ETV4, RUNX3, APC, EGR2, RXRA, EFNB1, NOTCH1,
DLX5, FOXG1, JAK2, EFNA5, NGFR, BMPR1B
GO:0030099~myeloid cell differentiation 7.96E-12 BMP4, MAEA, TNF, LYN, MMP9, CSF1, SMAD5, TGFBR2, PPARG, RB1, KIT, CBFB, TGFB1, TAL1, 481 93 13528 6.653164 3.10E-08 1.25E-10 1.48E-08
PSEN1, VEGFA, PSEN2, CASP8, JAK2, RUNX1, CHUK, ERCC2
GO:0033273~response to vitamin 8.21E-12 BMP4, BMP2, RARG, RXRA, PPARG, AQP3, TGFB1, CCNE1, ALDH1A2, VDR, CCND1, PLA2G4A, 481 66 13528 8.096516 3.19E-08 1.29E-10 1.52E-08 CD44, CDKN2D, BCL2, RARA, LRP2, INSR, SPP1
GO:0080135~regulation of cellular 8.26E-12 TNF, LYN, MAP4K1, TLR4, SIRT1, DAXX, PDCD4, BRCA1, TP73, TGFB2, AKT1, MEN1, MAP3K7, 481 103 13528 6.280282 3.21E-08 1.29E-10 1.53E-08 response to stress NOD2, EYA1, HIPK2, H2AFX, MTOR, CBS, AXIN1, AKT2, SYK, SPP1
GO:0042303~molting cycle 8.70E-12 FST, TP63, SOX9, TGFB2, AKT1, ATP7A, ACVR1B, NOTCH1, PSEN1, HOXC13, BCL2, PSEN2, 481 43 13528 10.46502 3.38E-08 1.35E-10 1.61E-08
NGFR, RUNX3, ERCC2, APC
GO:0042633~hair cycle 8.70E-12 FST, TP63, SOX9, TGFB2, AKT1, ATP7A, ACVR1B, NOTCH1, PSEN1, HOXC13, BCL2, PSEN2, 481 43 13528 10.46502 3.38E-08 1.35E-10 1.61E-08
NGFR, RUNX3, ERCC2, APC
GO:0048667~cell morphogenesis involved 1.23E-11 ERBB3, DRD2, ERBB2, PAX6, PAX2, GLI2, EPHB2, IGF1R, HOXA1, PTK2, BDNF, HOXA2, CXCR4, 481 209 13528 4.30618 4.76E-08 1.90E-10 2.27E-08 in neuron differentiation BCL2, GBX2, NKX2-1, PAFAH1B1, SNAP25, ETV4, RUNX3, APC, EGR2, RXRA, EFNB1, HES1,
NOTCH1, DLX5, FOXG1, JAK2, EFNA5, NGFR, BMPR1B
GO:0048584~positive regulation of 1.36E-11 TNF, STAT5A, STAT5B, FGF10, TLR4, ADA, TGFB1, SRC, TGFB2, MAP3K7, TNFRSF1A, NOD2, 481 236 13528 4.051869 5.29E-08 2.10E-10 2.52E-08 response to stimulus MYD88, INS, ZAP70, H2AFX, AXIN1, SYK, PTPRC, LYN, SMAD3, IGF2, IRS1, BRCA1, KDR,
MAPK1, PLA2G4A, EYA1, PSEN1, HIPK2, VEGFA, PLCG2, PSEN2, ADAM17, JAK2
GO:0048706~embryonic skeletal system 1.50E-11 NOG, GSC, MYF5, TGFBR2, TGFB3, COL2A1, ZEB1, GLI3, MEN1, ACVR2A, EYA1, HOXA2, 481 77 13528 7.305127 5.81E-08 2.30E-10 2.77E-08 development HOXB1, PAX7, SIX1, NKX3-2, TFAP2A, FOXC2, PBX1, COL1A1
GO:0051348~negative regulation of 1.53E-11 PTPRC, CAV1, NF2, PPARG, IGF2, RB1, SFN, PDCD4, TP73, LATS2, CDKN1C, AKT1, MEN1, 481 96 13528 6.445253 5.93E-08 2.34E-10 2.83E-08 transferase activity PDPK1, CDKN1A, CDKN2A, CDKN1B, PSEN1, INS, APOE, ILK, TSC2, APC
GO:0007517~muscle organ development 1.57E-11 MEF2C, CAV1, ACHE, ERBB3, ERBB2, TP63, PAX3, PTEN, TGFB2, PAX7, RARB, NRG1, NKX2-5, 481 211 13528 4.265363 6.12E-08 2.40E-10 2.92E-08
PITX1, GSC, RXRA, MYF5, MET, LMNA, IGF1, SIRT1, FOXP2, EP300, TSC1, MEOX2, MAPK14,
SIX1, FOXC2, PDGFRB, FOXC1, ENG, F2R
GO:0044057~regulation of system process 1.97E-11 CAV1, HRAS, ACHE, TNF, ERBB4, THRB, DRD2, FST, PTGS1, SNCA, KIT, SRF, ADA, EPHB2, 481 309 13528 3.549724 7.68E-08 3.00E-10 3.66E-08
TGFB2, EDNRB, BDNF, INS, APOE, NOS3, PRKACA, NKX2-5, EGR1, EGFR, MYO6, NOS1, EGR2,
HTT, SPHK1, GRIN1, IGF2, PARK2, HDAC4, PRKCQ, PSEN1, PSEN2, JAK2, ALOX5, EIF2AK3, F2R
GO:0070482~response to oxygen levels 2.40E-11 CAV1, IL18, STAT5B, TGFB3, ADA, TGFB1, CITED2, TGFB2, ARNT, CXCR4, BCL2, NOS3, NOS1, 481 141 13528 5.186122 9.32E-08 3.63E-10 4.44E-08
CREBBP, SMAD4, SMAD3, MMP14, CAPN2, PRKCQ, CDKN1A, EP300, PSEN2, VEGFA, ADAM17,
ENG, PLAU GO:0048839~inner ear development 2.44E-11 MYO6, MAFB, TGFB3, FGF10, COL2A1, PAX2, TGFB1, HES1, HOXA1, BDNF, EYA1, CHD7, 481 79 13528 7.120187 9.48E-08 3.67E-10 4.52E-08
CDKN1B, HES5, DLX6, DLX5, SIX1, FOXG1, GBX2, GFI1
GO:0010810~regulation of cell-substrate 2.66E-11 NF2, CSF1, MYF5, SMAD3, CDK6, MMP14, PTEN, CDKN2A, CD36, TSC1, BCL2, TSC2, ILK, 481 46 13528 9.782518 1.04E-07 4.00E-10 4.94E-08 adhesion COL1A1, RASA1, SPP1
GO:0006974~response to DNA damage 2.98E-11 XRCC5, NBN, BLM, NEK1, HUS1, PRKDC, TP63, SFN, MEN1, CASP9, CDKN2D, AATF, H2AFX, 481 373 13528 3.242262 1.16E-07 4.45E-10 5.51E-08 stimulus CCNA2, FANCA, TOP2A, APEX1, ERCC2, APC, CDK1, SSRP1, MYO6, LYN, POLG, TP53, BRCA2,
MBD4, ATR, SIRT1, RAD50, BRCA1, TP73, MAPK1, EYA1, CDKN1A, CCND1, VCP, PSEN1, HIPK1,
MAPK14
GO:0042770~DNA damage response, 3.09E-11 CDK1, NBN, MYO6, BLM, HUS1, TP53, TP63, BRCA2, MBD4, ATR, SFN, BRCA1, TP73, CCND1, 481 80 13528 7.031185 1.20E-07 4.61E-10 5.73E-08 signal transduction HIPK1, MAPK14, HIPK2, H2AFX, ABL1, CCNA2
GO:0033673~negative regulation of 3.45E-11 PTPRC, CAV1, NF2, IGF2, RB1, SFN, PDCD4, TP73, LATS2, AKT1, MEN1, CDKN1C, PDPK1, 481 90 13528 6.562439 1.34E-07 5.11E-10 6.39E-08 kinase activity CDKN1A, CDKN2A, CDKN1B, PSEN1, INS, APOE, ILK, TSC2, APC
GO:0010740~positive regulation of 3.51E-11 TNF, ERBB3, ERBB2, LEPR, FASLG, TLR4, TGFB1, TGFB2, MAP3K7, TNFRSF1A, NOD2, MYD88, 481 167 13528 4.715525 1.37E-07 5.19E-10 6.51E-08 protein kinase cascade REL, INS, ILK, CASP8, INSR, AXIN1, GHR, PTPRC, LYN, IGF1, FADD, IGF2, IKBKE, HIPK2, JAK2,
MTOR, F2R
GO:0051341~regulation of oxidoreductase 4.14E-11 EGFR, TNF, SNCA, NFKB1, IGF2, GCH1, AKT1, ATP7A, VDR, ACVR2A, APOE, INS, GFI1, ABL1, 481 40 13528 10.54678 1.61E-07 6.09E-10 7.66E-08 activity ENG, HDAC6
GO:0001817~regulation of cytokine 4.46E-11 TNF, STAT5A, IL18, PPARG, STAT5B, IGF2BP1, NFKB1, TLR4, TGFB1, TGFB2, ARNT, MAP3K7, 481 181 13528 4.506174 1.74E-07 6.55E-10 8.27E-08 production NOD2, MYD88, HSF1, REL, INS, GATA4, RARA, INPP5D, SYK, CEBPB, SMAD4, SMAD3, IGF2,
FOXP3, PRKCQ, ADAM17, JAK2, F2R
GO:0001666~response to hypoxia 4.85E-11 CAV1, IL18, STAT5B, TGFB3, ADA, TGFB1, CITED2, TGFB2, ARNT, CXCR4, BCL2, NOS3, NOS1, 481 134 13528 5.247153 1.88E-07 7.09E-10 8.98E-08
CREBBP, SMAD4, SMAD3, MMP14, CAPN2, PRKCQ, EP300, PSEN2, VEGFA, ADAM17, ENG,
PLAU
GO:0032582~negative regulation of 5.33E-11 MEF2C, BMP2, RXRA, PPARG, SMAD3, NFKB1, CDKN1C, HES1, HDAC4, VDR, HHEX, CDKN1B, 481 48 13528 9.374913 2.07E-07 7.76E-10 9.88E-08 gene-specific transcription HES5, GFI1, TBL1X, ENG
GO:0000060~protein import into nucleus, 5.65E-11 TNF, TP53, TGFB3, FGF10, GLI3, TGFB1, TGFB2, AKT1, MAPK1, JUN, SPTBN1, JAK2, FGF2, F2R 481 34 13528 11.58078 2.20E-07 8.19E-10 1.05E-07 translocation
GO:0065003~macromolecular complex 5.86E-11 EIF6, XPO1, HRAS, TP63, TBP, TGFB1, RANBP9, NOD2, APOE, ILK, CASP8, H2AFX, FAS, NRG1, 481 665 13528 2.537571 2.28E-07 8.46E-10 1.09E-07 assembly FANCA, INSR, MDN1, MYC, SYK, IKBKAP, TP53, PRKAB1, CDK9, FADD, MCM2, WAS, IRS1,
PPARGC1A, JUP, WASL, PRNP, EIF2AK3, MED1, CAV1, BLM, GRB2, ABCA1, SRC, GCH1,
TNFRSF1A, IG
GO:0060173~limb development 6.32E-11 WNT5A, NOG, RARG, LEF1, TP63, FGF10, COL2A1, GLI3, ALDH1A2, NOTCH1, CHD7, PSEN1, 481 103 13528 6.007226 2.45E-07 9.09E-10 1.17E-07
MEOX2, DLX6, BAX, DLX5, PSEN2, PBX1, RARB, BMPR1B, PITX1, MED1
GO:0048736~appendage development 6.32E-11 WNT5A, NOG, RARG, LEF1, TP63, FGF10, COL2A1, GLI3, ALDH1A2, NOTCH1, CHD7, PSEN1, 481 103 13528 6.007226 2.45E-07 9.09E-10 1.17E-07
MEOX2, DLX6, BAX, DLX5, PSEN2, PBX1, RARB, BMPR1B, PITX1, MED1
GO:0008544~epidermis development 6.65E-11 LOR, ELF3, FST, PAX6, FGF10, TP63, SFN, SOX9, GLI2, TGFB2, AKT1, ACVR1B, CDKN2A, CTGF, 481 184 13528 4.432704 2.59E-07 9.54E-10 1.23E-07
POU2F3, BCL2, RUNX3, ERCC2, APC, LEF1, WAS, ATP7A, PTHLH, NOTCH1, PSEN1, HOXC13,
PSEN2, COL1A1, NGFR
GO:0060537~muscle tissue development 6.99E-11 CAV1, ERBB3, RXRA, ERBB2, MYF5, TP63, PTEN, FOXP2, TGFB2, EP300, MEOX2, TSC1, 481 125 13528 5.39995 2.72E-07 9.98E-10 1.29E-07
MAPK14, PAX7, SIX1, FOXC2, PDGFRB, FOXC1, RARB, NRG1, NKX2-5, ENG, PITX1, F2R
GO:0045787~positive regulation of cell 7.46E-11 EGFR, TNF, STAT5A, STAT5B, SPHK1, IGF1, BRCA2, IGF2, BIRC5, TGFB2, CITED2, AKT1, 481 57 13528 8.38808 2.90E-07 1.06E-09 1.38E-07 cycle CCND1, INS, FOXG1, TGFA, ADAM17, INSR
GO:0010552~positive regulation of 7.46E-11 MEF2C, PPARG, TP53, SMAD3, PRKDC, FOXP3, SRF, CITED2, NR1H2, HES1, HDAC4, HHEX, 481 57 13528 8.38808 2.90E-07 1.06E-09 1.38E-07 specific transcription from RNA NOTCH1, HES5, ETS1, NKX2-5, ENG polymerase II promoter
GO:0042471~ear morphogenesis 8.54E-11 NOG, MYO6, MAFB, FGF10, COL2A1, PAX2, HOXA1, EYA1, HOXA2, CHD7, DLX6, DLX5, SIX1, 481 66 13528 7.670384 3.32E-07 1.21E-09 1.58E-07
FOXG1, GBX2, NKX3-2, GFI1, MYC
GO:0046777~protein amino acid 9.63E-11 EGFR, NLK, ERBB2, MET, KIT, STK4, AKT1, ACVR1B, IGF1R, PTK2, CSNK2A1, ZAP70, PDGFRB, 481 85 13528 6.617586 3.74E-07 1.36E-09 1.78E-07 autophosphorylation PRKACA, JAK2, MTOR, MAPK7, INSR, EIF2AK3, SYK
GO:0043933~macromolecular complex 1.01E-10 EIF6, XPO1, HRAS, TP63, TBP, TGFB1, RANBP9, NOD2, APOE, ILK, CASP8, H2AFX, FAS, NRG1, 481 710 13528 2.455963 3.91E-07 1.42E-09 1.86E-07 subunit organization FANCA, INSR, MDN1, MYC, SYK, IKBKAP, TP53, PRKAB1, CDK9, FADD, MCM2, PPARGC1A,
IRS1, WAS, TTF2, JUP, WASL, PRNP, EIF2AK3, XRN2, MED1, CAV1, BLM, GRB2, ABCA1, SRC, GCH1,
GO:0060249~anatomical structure 1.12E-10 XRCC5, BBS4, NBN, ERBB4, BLM, CSF1, PTH1R, PRKDC, COL2A1, SRF, RAD50, KDR, PTHLH, 481 106 13528 5.83721 4.34E-07 1.57E-09 2.07E-07 homeostasis PLA2G4A, DKC1, BAX, BCL2, VEGFA, PDGFRB, TERT, F2R, APC
GO:0052547~regulation of peptidase 1.20E-10 CAV1, TNF, SNCA, RAG1, TP53, SMAD3, BIRC5, SFN, STAT1, MEN1, CDKN2A, VCP, CASP9, 481 86 13528 6.540637 4.65E-07 1.67E-09 2.22E-07 activity BAX, CDKN2D, APAF1, EIF2AK3, MYC, F2R, HIP1
GO:0045667~regulation of osteoblast 1.27E-10 BMP4, BMP2, SMAD5, SMAD3, CDK6, SMAD1, MEN1, ACVR2A, DLX5, BMPR1B, RUNX2, CHRD, 481 43 13528 9.810956 4.92E-07 1.76E-09 2.35E-07 differentiation TWIST2, APC, ACVR1
GO:0048634~regulation of muscle 1.41E-10 BMP4, NOG, TGFBR2, SMAD3, LEF1, TGFB1, HDAC4, NOTCH1, BCL2, ILK, GATA4, NGFR, NRG1, 481 51 13528 8.823448 5.48E-07 1.96E-09 2.61E-07 development NKX2-5, FGF2, ACVR1
GO:0043405~regulation of MAP kinase 1.47E-10 CAV1, TNF, ERBB2, TGFB3, MAP4K1, KITLG, KIT, PDCD4, DAXX, TGFB1, APOE, CXCR4, ILK, 481 141 13528 4.986656 5.70E-07 2.03E-09 2.72E-07 activity TGFA, INSR, FGF2, GHR, SYK, EGFR, PTPRC, MET, TP73, PSEN1, TSC2, CBS
GO:0006469~negative regulation of 1.48E-10 PTPRC, CAV1, NF2, IGF2, RB1, SFN, PDCD4, TP73, LATS2, AKT1, MEN1, PDPK1, CDKN1A, 481 87 13528 6.465458 5.76E-07 2.04E-09 2.74E-07 protein kinase activity CDKN2A, CDKN1B, PSEN1, APOE, INS, ILK, TSC2, APC
GO:0042060~wound healing 1.63E-10 NOG, FOXA2, ERBB3, ERBB2, TGFB3, FGF10, ITGB3, SRF, TGFB1, TGFB2, CD44, INS, POU2F3, 481 191 13528 4.270249 6.35E-07 2.24E-09 3.03E-07
PAX7, NRG1, FGF2, TGFBR2, SMAD3, IGF1, IGF2, SMAD1, WAS, PRKCQ, NOTCH1, CD36, THBD,
ADAM17, ENG, PLAU, F2R
GO:0045778~positive regulation of 1.65E-10 BMP4, ACVR2A, PLA2G4A, BMP2, THRB, TGFB3, SMAD3, BMPR1B, RUNX2, TGFB1, TGFB2, 481 24 13528 14.06237 6.40E-07 2.25E-09 3.05E-07 ossification ACVR1
GO:0007179~transforming growth factor 1.75E-10 NLK, SMAD5, TGFBR2, TGFB3, SMAD4, SMAD3, SMAD2, SMAD1, TGFB1, TGFB2, MAP3K7, FOS, 481 60 13528 7.968676 6.79E-07 2.38E-09 3.23E-07 beta receptor signaling pathway ARRB2, ID1, JUN, ENG, ACVR1
GO:0043281~regulation of caspase 2.15E-10 TNF, SNCA, RAG1, TP53, SMAD3, BIRC5, SFN, STAT1, MEN1, CDKN2A, VCP, CASP9, BAX, 481 79 13528 6.764178 8.37E-07 2.93E-09 3.99E-07 activity CDKN2D, APAF1, EIF2AK3, MYC, F2R, HIP1
GO:0034097~response to cytokine 2.15E-10 SNCA, SOCS1, STAT1, SRF, SRC, STAT3, GCH1, STAT6, HDAC4, CCNE1, ALDH1A2, FOS, MYD88, 481 79 13528 6.764178 8.37E-07 2.93E-09 3.99E-07 stimulus JUN, BCL2, CASP8, NOS3, INSR, GHR
GO:0035107~appendage morphogenesis 2.16E-10 WNT5A, NOG, RARG, LEF1, TP63, FGF10, COL2A1, GLI3, ALDH1A2, NOTCH1, CHD7, PSEN1, 481 99 13528 5.965854 8.38E-07 2.92E-09 3.99E-07
DLX6, BAX, DLX5, PSEN2, PBX1, RARB, BMPR1B, PITX1, MED1 GO:0035108~limb morphogenesis 2.16E-10 WNT5A, NOG, RARG, LEF1, TP63, FGF10, COL2A1, GLI3, ALDH1A2, NOTCH1, CHD7, PSEN1, 481 99 13528 5.965854 8.38E-07 2.92E-09 3.99E-07
DLX6, BAX, DLX5, PSEN2, PBX1, RARB, BMPR1B, PITX1, MED1
GO:0048878~chemical homeostasis 2.18E-10 SNCA, PPARG, CXCR3, TGFB1, EDNRB, APOE, CXCR4, COL4A3BP, ILK, QKI, MYC, INSR, EGR2, 481 512 13528 2.746557 8.48E-07 2.95E-09 4.04E-07
CCKBR, TP53, IRS1, PPARGC1A, PTHLH, PSEN1, JUN, VEGFA, PRNP, CAV1, ERBB4, DRD2,
ERBB2, PTH1R, ABCA1, VDR, INS, BCL2, ERCC2, PTPRC, HTT, GRIN1, IGF1, IGF2, FZD2, STAT3,
KDR
GO:0048872~homeostasis of number of 2.61E-10 BMP4, MAEA, IL2RA, LYN, STAT5A, CSF1, SMAD5, STAT5B, RB1, FOXP3, TGFB1, AKT1, MEN1, 481 100 13528 5.906195 1.01E-06 3.51E-09 4.83E-07 cells TAL1, BAX, BCL2, VEGFA, FAS, IKBKB, F2R, ERCC2
GO:0032868~response to insulin stimulus 2.61E-10 AR, EGR2, LYN, ERBB3, GRB2, RXRA, PPARG, PRKDC, IGF2, STAT1, IRS1, AKT1, PRKCQ, IGF1R, 481 100 13528 5.906195 1.01E-06 3.51E-09 4.83E-07
PDPK1, TSC1, INS, FOXC2, MTOR, INSR, AKT2, GHR
GO:0050867~positive regulation of cell 2.76E-10 SELP, PTPRC, IL2RA, BLM, EFNB1, STAT5A, IL18, STAT5B, TGFBR2, IL13, TLR4, ADA, TGFB1, 481 111 13528 5.574273 1.07E-06 3.70E-09 5.12E-07 activation STAT6, MAP3K7, PRKCQ, CDKN1A, ZAP70, RARA, JAK2, INPP5D, SYK
GO:0032768~regulation of 2.85E-10 EGFR, TNF, SNCA, IGF2, NFKB1, GCH1, AKT1, VDR, ACVR2A, APOE, INS, GFI1, ENG 481 25 13528 13.49988 1.11E-06 3.80E-09 5.28E-07 monooxygenase activity
GO:0000278~mitotic cell cycle 3.11E-10 E2F1, BLM, NEK1, LATS2, AKT1, CCNE1, ACVR1B, NIPBL, CDKN2A, CDKN2C, CDKN2D, BCL2, 481 370 13528 3.116525 1.21E-06 4.14E-09 5.76E-07
NPAT, FBXO5, PAFAH1B1, GFI1, CCNA2, CDCA5, HELLS, APC, CDC7, EGFR, CDK1, PDS5B,
PDS5A, CCNF, TPX2, CDK6, BIRC5, RB1, CDC25C, CDC25A, CDK2, CDKN1C, CDKN1A, CCND1,
CDKN1B, NOL
GO:0001933~negative regulation of 4.11E-10 PTPRC, CAV1, NF2, SOCS1, PRKCD, TGFB1, MEN1, PSEN1, BAX, JUN, PSEN2, ENG, INSR 481 32 13528 11.42568 1.60E-06 5.45E-09 7.62E-07 protein amino acid phosphorylation
GO:0052548~regulation of endopeptidase 4.15E-10 TNF, SNCA, RAG1, TP53, SMAD3, BIRC5, SFN, STAT1, MEN1, CDKN2A, VCP, CASP9, BAX, 481 82 13528 6.516708 1.61E-06 5.48E-09 7.68E-07 activity CDKN2D, APAF1, EIF2AK3, MYC, F2R, HIP1
GO:0006259~DNA metabolic process 4.54E-10 XRCC5, NBN, MEN1, FOS, CDKN2A, DKC1, CTGF, CDKN2D, H2AFX, TOP2A, MYC, FANCA, 481 506 13528 2.723542 1.77E-06 5.98E-09 8.41E-07
TERT, CDC7, POLG, TP53, MBD4, MCM2, CDK2, RAD50, EYA1, XRN2, MED1, ACHE, BLM, LIN9,
HUS1, RAG1, PRKDC, RAG2, TK1, APEX1, HELLS, ERCC2, SSRP1, MLL, BRCA2, IGF1, ATR,
CDC25C, SIRT1 GO:0003007~heart morphogenesis 4.77E-10 BBS4, BMP2, RXRA, COL2A1, SRF, ZIC3, TGFB2, ALDH1A2, CHD7, PSEN1, COL4A3BP, GATA4, 481 73 13528 6.934867 1.85E-06 6.26E-09 8.83E-07
MKKS, FOXC2, FOXC1, INSR, NKX2-5, ENG
GO:0001704~formation of primary germ 6.02E-10 BMP4, TBX6, FOXA2, NF2, HTT, SMAD3, LEF1, SMAD2, SMAD1, FOXC2, FOXC1, PRKACA, 481 40 13528 9.843659 2.34E-06 7.88E-09 1.12E-06 layer CHRD, ACVR1
GO:0048771~tissue remodeling 6.10E-10 CAV1, ELF3, ERBB3, ERBB2, PTH1R, TGFB3, FGF10, MMP14, TGFB1, ATP7A, BAX, VEGFA, 481 56 13528 8.03564 2.37E-06 7.96E-09 1.13E-06
FOXC2, NOS3, FOXC1, F2R
GO:0045639~positive regulation of 6.25E-10 CSF1, STAT5A, KITLG, RB1, ARNT, ACVR1B, TAL1, ACVR2A, ETS1, JUN, MAPK14, INPP5D, 481 33 13528 11.07944 2.43E-06 8.13E-09 1.16E-06 myeloid cell differentiation RUNX1
GO:0032944~regulation of mononuclear 6.31E-10 PTPRC, IL2RA, BLM, EFNB1, STAT5A, CSF1, ERBB2, IL18, STAT5B, IL13, FOXP3, ADA, TGFB1, 481 84 13528 6.361548 2.45E-06 8.18E-09 1.17E-06 cell proliferation PRKCQ, CDKN1A, CDKN2A, ZAP70, INPP5D, SYK
GO:0070663~regulation of leukocyte 6.31E-10 PTPRC, IL2RA, BLM, EFNB1, STAT5A, CSF1, ERBB2, IL18, STAT5B, IL13, FOXP3, ADA, TGFB1, 481 84 13528 6.361548 2.45E-06 8.18E-09 1.17E-06 proliferation PRKCQ, CDKN1A, CDKN2A, ZAP70, INPP5D, SYK
GO:0021537~telencephalon development 6.42E-10 BMP4, BBS4, ERBB4, HTT, DRD2, GRIN1, PAX6, LEF1, GLI3, TP73, FOXP2, PSEN1, TSC1, BAX, 481 65 13528 7.355701 2.50E-06 8.29E-09 1.19E-06
NKX2-1, MKKS, PAFAH1B1
GO:0021532~neural tube patterning 7.16E-10 HES1, BMP4, GSC, PSEN1, FOXA2, PAX7, PSEN2, PAX6, GBX2, MNX1, GLI2 481 21 13528 14.73201 2.78E-06 9.21E-09 1.33E-06
GO:0048469~cell maturation 7.49E-10 RET, MAEA, PTH1R, PPARG, BRCA2, CBFB, KDR, BTK, CDKN1C, HES1, HES5, VEGFA, GDF11, 481 75 13528 6.749938 2.91E-06 9.61E-09 1.39E-06
FBXO5, RUNX2, RUNX3, AXIN1, ERCC2
GO:0022612~gland morphogenesis 7.59E-10 EGFR, CAV1, ELF3, ERBB3, ERBB2, BCL2, PAX6, TGFB3, TGFB1, TGFB2 481 16 13528 17.57796 2.95E-06 9.70E-09 1.41E-06
GO:0033077~T cell differentiation in the 7.81E-10 PTPRC, BCL2, STAT5A, STAT5B, ZAP70, TP53, RAG1, ADAM17, PRKDC, FAS, RAG2, APC 481 27 13528 12.49988 3.04E-06 9.95E-09 1.45E-06 thymus
GO:0050679~positive regulation of 8.54E-10 EGFR, NOG, ERBB4, ERBB2, IGF1, FGF10, TGFB1, KDR, FOXP2, DLX6, DLX5, VEGFA, TGFA, 481 41 13528 9.60357 3.32E-06 1.08E-08 1.58E-06 epithelial cell proliferation FGF2
GO:0010035~response to inorganic 8.66E-10 CAV1, ERBB4, SLC6A3, SNCA, PTEN, ADA, AQP3, FOS, APOE, BCL2, NOS3, INSR, EGFR, HTT, 481 205 13528 3.978622 3.37E-06 1.10E-08 1.60E-06 substance RXRA, LEF1, STAT1, ATP7A, CDKN1A, CCND1, PLA2G4A, EP300, JUN, PLCG2, MAPK9, MAPK8,
COL1A1, PRNP, HDAC6
GO:0060341~regulation of cellular 9.99E-10 ACHE, TNF, DRD2, FST, PTGS1, SNCA, TGFB3, IL13, GLI3, TGFB1, TGFB2, NOD2, CHD7, 481 248 13528 3.628999 3.88E-06 1.26E-08 1.85E-06 localization CDKN2A, INS, SCG5, PRKACA, SNAP25, FGF2, SYK, APC, BMP4, SMAD4, SMAD3, IGF2, PARK2,
FOXP3, SIRT1, GCG, PRKCQ, NEUROD1, JAK2, MBTPS1
GO:0016202~regulation of striated muscle 1.21E-09 BMP4, NOG, TGFBR2, SMAD3, LEF1, TGFB1, HDAC4, NOTCH1, BCL2, GATA4, ILK, NRG1, 481 50 13528 8.437422 4.69E-06 1.52E-08 2.23E-06 tissue development NKX2-5, FGF2, ACVR1
GO:0001658~branching involved in 1.27E-09 BMP4, EYA1, BMP2, CD44, BCL2, ILK, SIX1, SMAD4, PBX1, PAX2, GLI3 481 22 13528 14.06237 4.94E-06 1.59E-08 2.35E-06 ureteric bud morphogenesis
GO:0060675~ureteric bud morphogenesis 1.27E-09 BMP4, EYA1, BMP2, CD44, BCL2, ILK, SIX1, SMAD4, PBX1, PAX2, GLI3 481 22 13528 14.06237 4.94E-06 1.59E-08 2.35E-06
GO:0050730~regulation of 1.32E-09 EGFR, PTPRC, CAV1, NF2, LYN, SOCS1, IGF1, KITLG, TLR4, IGF2, PRKCD, NOD2, INS, PDGFRB, 481 68 13528 7.031185 5.13E-06 1.65E-08 2.44E-06 peptidyl-tyrosine phosphorylation JAK2, MTOR, SYK, GHR
GO:0032870~cellular response to 1.52E-09 ERBB3, GRB2, STAT5A, RXRA, PPARG, STAT5B, PRKDC, IGF2, STAT1, IRS1, LATS2, STAT3, 481 133 13528 4.863677 5.90E-06 1.89E-08 2.81E-06 hormone stimulus GCG, AKT1, FOS, IGF1R, PDPK1, INS, FOXC2, JAK2, PRKACA, INSR, AKT2, GHR
GO:0002684~positive regulation of 1.53E-09 BLM, STAT5A, IL18, STAT5B, IL13, TLR4, ADA, TGFB1, AQP3, TGFB2, STAT6, MAP3K7, NOD2, 481 238 13528 3.663306 5.95E-06 1.90E-08 2.84E-06 immune system process MYD88, ZAP70, RARA, INPP5D, SYK, PTPRC, IL2RA, LYN, EFNB1, TGFBR2, MAPK1, PRKCQ,
CDKN1A, PSEN1, VEGFA, PLCG2, PSEN2, ADAM17
GO:0045926~negative regulation of 1.54E-09 PPARG, TP53, SMAD4, SMAD3, TP63, RB1, ESR2, TGFB1, TP73, TGFB2, MEN1, ACVR1B, PTK2, 481 110 13528 5.369269 5.98E-06 1.90E-08 2.85E-06 growth CDKN1A, CDKN2A, CDKN1B, CDKN2C, CDKN2D, BCL2, FGF2, SPP1
GO:0007565~female pregnancy 1.54E-09 STAT5A, RXRA, LEPR, TGFBR2, STAT5B, TGFB3, TGFB1, CITED2, PTHLH, MEN1, FOS, VDR, 481 110 13528 5.369269 5.98E-06 1.90E-08 2.85E-06
PLA2G4A, THBD, PRLR, HSF1, BCL2, EPOR, LIPE, PLAU, SPP1
GO:0043524~negative regulation of 1.61E-09 HRAS, ERBB3, HTT, SNCA, GRIN1, TGFB3, TP73, BDNF, PSEN1, BAX, BCL2, HIPK2, ILK, RASA1, 481 51 13528 8.271982 6.25E-06 1.99E-08 2.98E-06 neuron apoptosis F2R
GO:0031099~regeneration 1.66E-09 RXRA, SOCS1, PPARG, IGF1, FGF10, TGFB1, CCNE1, PRKCQ, NOTCH1, CCND1, CDKN1A, PAX7, 481 69 13528 6.929284 6.46E-06 2.05E-08 3.08E-06
BCL2, JAK2, LRP2, CCNA2, PLAU
GO:0070302~regulation of stress-activated 1.66E-09 TNF, LYN, MAP4K1, TLR4, PDCD4, DAXX, TP73, TGFB2, AKT1, MEN1, MAP3K7, NOD2, HIPK2, 481 69 13528 6.929284 6.46E-06 2.05E-08 3.08E-06 protein kinase signaling pathway CBS, AXIN1, AKT2, SYK
GO:0045785~positive regulation of cell 1.75E-09 TNF, CSF1, ERBB2, SMAD3, CDK6, VAV1, SRC, TGFB2, CITED2, CD36, TSC1, ILK, NRG1, CHRD, 481 60 13528 7.499931 6.81E-06 2.15E-08 3.25E-06 adhesion APC, SPP1 GO:0010212~response to ionizing 1.75E-09 PTPRC, CAV1, BLM, NEK1, TP53, PRKDC, BRCA2, BRCA1, MEN1, CCND1, EYA1, THBD, BAX, 481 60 13528 7.499931 6.81E-06 2.15E-08 3.25E-06 radiation BCL2, H2AFX, LRP2
GO:0030902~hindbrain development 1.75E-09 EGR2, FOXA2, MAFB, GRIN1, SMAD1, GLI2, FOXP2, HES1, ATP7A, HOXA1, ALDH1A2, HOXA2, 481 60 13528 7.499931 6.81E-06 2.15E-08 3.25E-06
HOXB1, BCL2, GBX2, NEUROD1
GO:0048565~gut development 2.00E-09 RET, RXRA, TGFB3, FGF10, GLI2, GLI3, TGFB1, ADA, EDNRB, ALDH1A2, NOTCH1, BCL2, 481 36 13528 10.15616 7.78E-06 2.45E-08 3.71E-06
GATA4
GO:0001707~mesoderm formation 2.00E-09 BMP4, TBX6, NF2, HTT, LEF1, SMAD3, SMAD2, SMAD1, FOXC2, FOXC1, PRKACA, CHRD, 481 36 13528 10.15616 7.78E-06 2.45E-08 3.71E-06
ACVR1
GO:0008624~induction of apoptosis by 2.14E-09 BID, TNF, AKAP13, FASLG, FADD, VAV1, DAXX, BTK, VDR, PSEN1, BAX, SOS1, PSEN2, CASP8, 481 112 13528 5.273389 8.31E-06 2.61E-08 3.96E-06 extracellular signals RIPK3, MAPK9, MAPK8, AATF, FAS, NGFR, CASP2
GO:0051249~regulation of lymphocyte 2.27E-09 PTPRC, IL2RA, BLM, EFNB1, STAT5A, ERBB2, IL18, STAT5B, TGFBR2, IL13, ZEB1, FOXP3, ADA, 481 148 13528 4.560769 8.82E-06 2.76E-08 4.20E-06 activation TGFB1, STAT6, MAP3K7, PRKCQ, CDKN1A, CDKN2A, ZAP70, RARA, FAS, INPP5D, SYK
GO:0030308~negative regulation of cell 3.00E-09 PPARG, TP53, SMAD4, SMAD3, TP63, RB1, ESR2, TP73, TGFB1, TGFB2, ACVR1B, CDKN1A, 481 92 13528 5.80837 1.16E-05 3.63E-08 5.55E-06 growth CDKN2A, CDKN1B, CDKN2C, CDKN2D, BCL2, FGF2, SPP1
GO:0032880~regulation of protein 3.11E-09 BMP4, ACHE, TNF, DRD2, TGFB3, SMAD4, SMAD3, IL13, IGF2, FOXP3, SIRT1, GLI3, TGFB1, 481 138 13528 4.687457 1.21E-05 3.75E-08 5.76E-06 localization TGFB2, AKT1, PRKCQ, NOD2, PDPK1, INS, BCL2, JAK2, PRKACA, MBTPS1, APC
GO:0033043~regulation of organelle 3.21E-09 XPO1, CAV1, TNF, SNCA, MEN1, INS, ILK, TGFA, INSR, MYC, RASA1, APC, MLL, NF2, SMAD3, 481 217 13528 3.758606 1.25E-05 3.86E-08 5.94E-06 organization IGF1, IGF2, FOXP3, CDC25C, PPARGC1A, BRCA1, PRKCQ, PLA2G4A, CDKN1B, TSC1, TSC2,
DNMT1, SPTBN1, MTOR, HDAC6
GO:0051241~negative regulation of 3.51E-09 CAV1, ACHE, NOG, TNF, DRD2, PPARG, NFKB1, SOX9, ADA, NOD2, HSF1, APOE, INS, NOS3, 481 164 13528 4.287308 1.36E-05 4.21E-08 6.50E-06 multicellular organismal process RARA, INPP5D, TGFBR2, IGF2, FOXP3, NOTCH1, VEGFA, ADAM17, JAK2, NGFR, EIF2AK3, PLAU
GO:0008629~induction of apoptosis by 3.66E-09 TP53, TP63, BRCA2, MBD4, SFN, TP73, BRCA1, CDKN1A, HIPK1, HTRA2, BAX, HIPK2, JAK2, 481 54 13528 7.812428 1.42E-05 4.38E-08 6.79E-06 intracellular signals ABL1, MYC
GO:0050670~regulation of lymphocyte 3.96E-09 PTPRC, IL2RA, BLM, EFNB1, STAT5A, ERBB2, IL18, STAT5B, IL13, FOXP3, ADA, TGFB1, PRKCQ, 481 83 13528 6.099341 1.54E-05 4.72E-08 7.33E-06 proliferation CDKN1A, CDKN2A, ZAP70, INPP5D, SYK
GO:0048332~mesoderm morphogenesis 4.06E-09 BMP4, TBX6, NF2, HTT, LEF1, SMAD3, SMAD2, SMAD1, FOXC2, FOXC1, PRKACA, CHRD, 481 38 13528 9.621622 1.58E-05 4.82E-08 7.52E-06 ACVR1
GO:0006366~transcription from RNA 4.28E-09 TAF1C, ELF3, FOXM1, CCNT1, TBP, NFKB1, PAX3, PAX2, CBFB, ARNT, GATA3, GATA4, NKX3-2, 481 234 13528 3.605736 1.67E-05 5.08E-08 7.94E-06 polymerase II promoter NFATC4, MYC, APEX1, NFATC3, RUNX3, ERCC2, KLF5, TAF4, MLL, CEBPB, TAF5, CDK9,
STAT1, PPARGC1A, ETS1, MED1, NR5A1
GO:0034504~protein localization in 4.30E-09 BBS4, XPO1, TNF, HTT, TP53, TGFB3, FGF10, GLI3, TGFB1, TGFB2, AKT1, MAPK1, JUN, TSC2, 481 94 13528 5.684788 1.67E-05 5.08E-08 7.97E-06 nucleus SPTBN1, JAK2, FGF2, F2R, NR5A1
GO:0002694~regulation of leukocyte 4.49E-09 BLM, IL18, ERBB2, STAT5A, SNCA, STAT5B, IL13, ZEB1, ADA, TGFB1, STAT6, MAP3K7, 481 166 13528 4.235654 1.75E-05 5.29E-08 8.32E-06 activation CDKN2A, ZAP70, RARA, FAS, INPP5D, SYK, PTPRC, IL2RA, EFNB1, TGFBR2, FOXP3, PRKCQ,
CDKN1A
GO:0045471~response to ethanol 4.61E-09 DRD2, SLC6A3, STAT5B, GRIN1, TLR4, PTEN, STAT3, TNFRSF1A, CCNE1, CCND1, EP300, APOE, 481 64 13528 7.031185 1.79E-05 5.41E-08 8.54E-06
BCL2, NKX2-1, NOS3, INSR
GO:0032269~negative regulation of 4.97E-09 CAV1, SNCA, IGF2BP1, NFKB1, ITGB3, TGFB1, MEN1, CDKN2A, INS, FBXO5, INSR, PTPRC, 481 180 13528 4.062462 1.93E-05 5.82E-08 9.20E-06 cellular protein metabolic process GTPBP4, NF2, SOCS1, IGF2, FOXP3, PRKCD, TSC1, PSEN1, JUN, BAX, PSEN2, DNMT1, EIF2AK3,
ENG, HDAC6
GO:0044087~regulation of cellular 5.39E-09 BBS4, CAV1, NF2, GRIN1, TGFB3, SMAD3, KIT, MMP14, SRF, PTEN, PRKCQ, PTK2, CDKN1B, 481 142 13528 4.555416 2.09E-05 6.29E-08 9.98E-06 component biogenesis TSC1, TSC2, SPTBN1, MTOR, MDN1, SNAP25, NKX2-5, RASA1, APC, HDAC6
GO:0042063~gliogenesis 5.80E-09 EGFR, EGR2, LYN, NF2, ERBB3, SOX11, ERBB2, IGF1, CDK6, MMP14, TGFB2, NOTCH1, CDKN2C, 481 65 13528 6.923013 2.25E-05 6.75E-08 1.07E-05
NKX2-1, FGF2, ERCC2
GO:0050680~negative regulation of 5.83E-09 CDKN1C, CDKN1B, TSC2, PAX6, BRCA2, CDK6, ESR2, RUNX3, TGFB1, TGFB2, APC 481 25 13528 12.37489 2.27E-05 6.77E-08 1.08E-05 epithelial cell proliferation
GO:0040018~positive regulation of 5.83E-09 AKT1, CHD7, HSF1, DRD2, SLC6A3, BCL2, STAT5A, CSF1, STAT5B, TSHR, GHR 481 25 13528 12.37489 2.27E-05 6.77E-08 1.08E-05 multicellular organism growth
GO:0021675~nerve development 5.83E-09 HES1, HOXA1, HOXB1, BDNF, CHD7, EGR2, ERBB3, MNX1, NGFR, GLI3, EPHB2 481 25 13528 12.37489 2.27E-05 6.77E-08 1.08E-05
GO:0043010~camera-type eye 5.97E-09 BMP4, PAX6, ZEB1, PAX2, GLI3, WT1, FOXP2, EPHB2, ALDH1A2, CHD7, BAX, VEGFA, POU2F1, 481 107 13528 5.256961 2.32E-05 6.90E-08 1.11E-05 development GDF11, NEUROD1, FOXC2, FOXC1, BMPR1B, APC, MED1
GO:0051054~positive regulation of DNA 6.14E-09 PTPRC, HRAS, TGFB3, IGF1, KITLG, IGF2, GLI2, TGFB1, BRCA1, STAT6, IGF1R, EYA1, INS, JUN, 481 56 13528 7.533413 2.39E-05 7.08E-08 1.14E-05 metabolic process H2AFX, INSR
GO:0014706~striated muscle tissue 6.39E-09 CAV1, ERBB3, RXRA, ERBB2, MYF5, PTEN, FOXP2, TGFB2, EP300, MEOX2, TSC1, MAPK14, 481 119 13528 4.963189 2.48E-05 7.35E-08 1.18E-05 development PAX7, SIX1, FOXC2, FOXC1, RARB, NRG1, NKX2-5, PITX1, F2R
GO:0006913~nucleocytoplasmic transport 6.45E-09 XPO1, TNF, HTT, NXF2, TP53, TGFB3, FGF10, NXF1, GLI3, TGFB1, TGFB2, AKT1, MAPK1, HHEX, 481 156 13528 4.326883 2.51E-05 7.39E-08 1.19E-05
NUP214, CAMK4, TSC1, JUN, TSC2, LSG1, SPTBN1, JAK2, FGF2, F2R
GO:0051251~positive regulation of 7.27E-09 PTPRC, IL2RA, BLM, EFNB1, STAT5A, IL18, STAT5B, TGFBR2, IL13, ADA, TGFB1, STAT6, 481 97 13528 5.50897 2.83E-05 8.31E-08 1.35E-05 lymphocyte activation MAP3K7, PRKCQ, CDKN1A, ZAP70, RARA, INPP5D, SYK
GO:0043410~positive regulation of 7.45E-09 PTPRC, TNF, LEPR, ERBB2, TLR4, IGF2, TGFB2, MAP3K7, NOD2, INS, HIPK2, ILK, INSR, F2R, 481 48 13528 8.203049 2.89E-05 8.49E-08 1.38E-05
MAPKKK cascade AXIN1
GO:0048704~embryonic skeletal system 7.88E-09 NOG, GSC, MYF5, TGFBR2, TGFB3, COL2A1, ZEB1, GLI3, MEN1, EYA1, HOXA2, HOXB1, SIX1, 481 57 13528 7.401247 3.06E-05 8.95E-08 1.46E-05 morphogenesis TFAP2A, FOXC2
GO:0051169~nuclear transport 8.28E-09 XPO1, TNF, HTT, NXF2, TP53, TGFB3, FGF10, NXF1, GLI3, TGFB1, TGFB2, AKT1, MAPK1, HHEX, 481 158 13528 4.272112 3.22E-05 9.38E-08 1.53E-05
NUP214, CAMK4, TSC1, JUN, TSC2, LSG1, SPTBN1, JAK2, FGF2, F2R
GO:0051101~regulation of DNA binding 8.60E-09 TNF, TLR4, FOXP3, SIRT1, TGFB1, PTHLH, MEN1, HDAC4, PRKCQ, NOD2, CDKN2A, EP300, 481 121 13528 4.881153 3.34E-05 9.72E-08 1.59E-05
MYD88, ID1, HIPK2, PBX1, JAK2, BRD4, IKBKB, APEX1, ERCC2
GO:0070201~regulation of establishment 8.60E-09 BMP4, ACHE, TNF, DRD2, TGFB3, SMAD4, SMAD3, IL13, IGF2, FOXP3, SIRT1, GLI3, TGFB1, 481 121 13528 4.881153 3.34E-05 9.72E-08 1.59E-05 of protein localization TGFB2, AKT1, PRKCQ, NOD2, PDPK1, INS, JAK2, PRKACA, MBTPS1
GO:0014033~neural crest cell 9.55E-09 ALDH1A2, EDNRB, RET, EFNB1, GBX2, FOXC2, KITLG, FOXC1, PAX3, SOX9, NRG1, ACVR1 481 33 13528 10.22718 3.71E-05 1.08E-07 1.77E-05 differentiation
GO:0014032~neural crest cell 9.55E-09 ALDH1A2, EDNRB, RET, EFNB1, GBX2, FOXC2, KITLG, FOXC1, PAX3, SOX9, NRG1, ACVR1 481 33 13528 10.22718 3.71E-05 1.08E-07 1.77E-05 development
GO:0019217~regulation of fatty acid 9.81E-09 CAV1, STK11, SNCA, PPARG, PRKAB1, IGF2, IRS1, PPARGC1A, BRCA1, NR1H2, AKT1, PLA2G4A, 481 49 13528 8.03564 3.81E-05 1.10E-07 1.82E-05 metabolic process INS, MTOR, AKT2
GO:0010553~negative regulation of 1.07E-08 MEF2C, RXRA, PPARG, SMAD3, NFKB1, HES1, VDR, HHEX, HDAC4, HES5, GFI1, TBL1X, ENG 481 41 13528 8.917601 4.18E-05 1.20E-07 1.99E-05 specific transcription from RNA polymerase II promoter GO:0051248~negative regulation of 1.10E-08 CAV1, SNCA, IGF2BP1, NFKB1, ITGB3, TGFB1, MEN1, CDKN2A, INS, FBXO5, INSR, PTPRC, 481 187 13528 3.910392 4.26E-05 1.22E-07 2.03E-05 protein metabolic process GTPBP4, NF2, SOCS1, IGF2, FOXP3, PRKCD, TSC1, PSEN1, JUN, BAX, PSEN2, DNMT1, EIF2AK3,
ENG, HDAC6
GO:0051336~regulation of hydrolase 1.19E-08 CAV1, TNF, DRD2, LEPR, PTH1R, SNCA, RAG1, SFN, TGFB2, MEN1, NR1H2, EDNRB, CDKN2A, 481 337 13528 3.004423 4.63E-05 1.33E-07 2.21E-05 activity CASP9, CDKN2D, NOS3, PAFAH1B1, MYC, HIP1, EGFR, CCKBR, TP53, SMAD3, BIRC5, STAT1,
VAV1, SIRT1, VCP, TSC1, BAX, TSC2, JAK2, APAF1, MTOR, EIF2AK3, F2R
GO:0051046~regulation of secretion 1.24E-08 ACHE, TNF, ERBB3, DRD2, PTGS1, SNCA, FST, TGFB3, IL13, TGFB1, ADA, TGFB2, NOD2, CHD7, 481 202 13528 3.759247 4.83E-05 1.38E-07 2.30E-05
INS, SCG5, NRG1, SNAP25, FGF2, SYK, MYO6, IGF2, PARK2, FOXP3, GCG, PRKCQ, NEUROD1,
JAK2
GO:0048663~neuron fate commitment 1.46E-08 BMP4, FOXA2, SMAD4, PAX6, PAX3, GLI2, GLI3, TGFB2, HES1, NOTCH1, HES5, PAX7, NKX2-1 481 42 13528 8.705277 5.66E-05 1.61E-07 2.70E-05
GO:0006954~inflammatory response 1.61E-08 TNF, S100A8, ELF3, STAT5B, IL13, NFKB1, TLR4, TGFB1, AKT1, FOS, TNFRSF1A, TNFRSF1B, 481 325 13528 3.028818 6.25E-05 1.77E-07 2.98E-05
MYD88, CD44, CXCR4, INS, NFATC4, NFATC3, SPP1, SELP, BMP2, IL2RA, CEBPB, LYN, RXRA,
IGF2, SMAD1, TP73, STAT3, HDAC4, CYBB, TSC2, ALOX5, BMPR1B, F2R, ACVR1
GO:0001890~placenta development 1.61E-08 CEBPB, RXRA, CCNF, PPARG, LEF1, ADA, ARNT, CITED2, AKT1, VDR, PLA2G4A, HSF1, EPOR, 481 60 13528 7.031185 6.26E-05 1.77E-07 2.98E-05
SPP1, MED1
GO:0043406~positive regulation of MAP 1.66E-08 EGFR, PTPRC, TNF, ERBB2, MET, TGFB3, MAP4K1, KITLG, KIT, DAXX, TGFB1, PSEN1, CXCR4, 481 102 13528 5.238922 6.47E-05 1.83E-07 3.08E-05 kinase activity ILK, TGFA, INSR, FGF2, SYK, GHR
GO:0001708~cell fate specification 1.67E-08 BMP4, TBX6, FOXA2, FGF10, SOX9, GLI2, GLI3, NOTCH1, PSEN1, SIX1, PSEN2, POU2F1, NKX2-1, 481 51 13528 7.720517 6.48E-05 1.83E-07 3.09E-05
FGF2
GO:0000075~cell cycle checkpoint 1.72E-08 CDK1, NBN, BLM, HUS1, TP53, BIRC5, RB1, ATR, TGFB1, BRCA1, CCND1, CDKN2A, MAPK14, 481 91 13528 5.563135 6.67E-05 1.87E-07 3.18E-05
H2AFX, CCNA2, APC, DLG1, ERCC2
GO:0051301~cell division 1.82E-08 BBS4, MAEA, NEK1, CCNT1, KIT, DAXX, LATS2, TGFB2, CCNE1, CDKN2A, FBXO5, AATF, 481 295 13528 3.146157 7.06E-05 1.98E-07 3.37E-05
PAFAH1B1, CDCA5, CCNA2, HELLS, RASA1, ERCC2, APC, CDC7, CDK1, PDS5B, PDS5A, CCNF,
BRCA2, CDK6, BIRC5, RB1, CDC25C, CDC25A, CDK2, CCND1, NOTCH1
GO:0007050~cell cycle arrest 1.95E-08 NBN, STK11, TP53, SMAD3, RB1, TP73, TGFB1, TGFB2, CDKN1C, MEN1, CDKN1A, CDKN2A, 481 103 13528 5.188059 7.59E-05 2.12E-07 3.62E-05
CDKN1B, CDKN2C, RASSF1, CDKN2D, ILK, MYC, APC GO:0040014~regulation of multicellular 2.02E-08 DRD2, STAT5A, CSF1, SLC6A3, STAT5B, IGF1, STAT3, AKT1, CHD7, HTRA2, HSF1, APOE, BCL2, 481 61 13528 6.91592 7.86E-05 2.19E-07 3.75E-05 organism growth TSHR, GHR
GO:0051291~protein 2.15E-08 HRAS, GRB2, PRKAB1, FADD, IRS1, GCH1, JUP, TNFRSF1A, IGF1R, TSC1, CASP8, TSC2, ILK, 481 52 13528 7.572045 8.37E-05 2.32E-07 3.99E-05 heterooligomerization INSR
GO:0031644~regulation of neurological 2.20E-08 EGFR, EGR1, HRAS, ACHE, TNF, EGR2, MYO6, ERBB4, HTT, DRD2, GRIN1, SNCA, KIT, PARK2, 481 153 13528 4.227902 8.57E-05 2.37E-07 4.08E-05 system process EPHB2, EDNRB, BDNF, PSEN1, APOE, PSEN2, PRKACA, EIF2AK3, F2R
GO:0033280~response to vitamin D 2.38E-08 VDR, PLA2G4A, CDKN2D, RXRA, LRP2, INSR, AQP3, TGFB1, SPP1 481 16 13528 15.82017 9.23E-05 2.55E-07 4.40E-05
GO:0030509~BMP signaling pathway 2.60E-08 BMP4, BMP2, NOG, SMAD5, FST, SMAD4, SMAD1, ACVR2A, ID1, BMPR1B, ENG, CHRD, ACVR1 481 44 13528 8.309582 1.01E-04 2.79E-07 4.82E-05
GO:0048286~lung alveolus development 2.73E-08 PTHLH, ATP7A, BMP4, VEGFA, PSEN2, TGFB3, FGF10, ADA, KDR, FOXP2 481 22 13528 12.78397 1.06E-04 2.91E-07 5.05E-05
GO:0008633~activation of pro-apoptotic 2.73E-08 BID, AKT1, BCL2, CASP8, SMAD3, FASLG, MAPK8, FADD, FAS, MYC 481 22 13528 12.78397 1.06E-04 2.91E-07 5.05E-05 gene products
GO:0010638~positive regulation of 2.84E-08 CAV1, TNF, NF2, SMAD3, IGF1, IGF2, FOXP3, PPARGC1A, MEN1, PRKCQ, PLA2G4A, CDKN1B, 481 83 13528 5.760489 1.10E-04 3.03E-07 5.26E-05 organelle organization INS, DNMT1, TGFA, MTOR, INSR, APC
GO:0002696~positive regulation of 3.11E-08 PTPRC, IL2RA, BLM, EFNB1, STAT5A, IL18, STAT5B, TGFBR2, IL13, ADA, TGFB1, STAT6, 481 106 13528 5.041227 1.21E-04 3.30E-07 5.76E-05 leukocyte activation MAP3K7, PRKCQ, CDKN1A, ZAP70, RARA, INPP5D, SYK
GO:0030856~regulation of epithelial cell 3.15E-08 CAV1, CCND1, NOTCH1, PRLR, STAT5A, STAT5B, PAX6, TP63, ZEB1, AQP3, APC 481 29 13528 10.668 1.22E-04 3.33E-07 5.83E-05 differentiation
GO:0032355~response to estradiol 3.52E-08 BMP4, STAT5B, SOCS1, PTEN, STAT3, TGFB1, ALDH1A2, CCNE1, NOS3, RARA, NKX2-5, CCNA2, 481 54 13528 7.291599 1.37E-04 3.72E-07 6.52E-05 stimulus INSR, GHR
GO:0031400~negative regulation of 3.63E-08 PTPRC, CAV1, GTPBP4, NF2, SNCA, SOCS1, FOXP3, PRKCD, TGFB1, MEN1, CDKN2A, PSEN1, 481 119 13528 4.726847 1.41E-04 3.83E-07 6.73E-05 protein modification process TSC1, JUN, BAX, PSEN2, DNMT1, FBXO5, INSR, ENG
GO:0031960~response to corticosteroid 4.05E-08 BMP4, CAV1, TNF, RXRA, PTGS1, SRC, CCNE1, FOS, CCND1, PLA2G4A, CDKN1A, EP300, BCL2, 481 85 13528 5.624948 1.57E-04 4.26E-07 7.50E-05 stimulus COL1A1, FAS, INSR, GHR
GO:0043467~regulation of generation of 4.57E-08 ATP7A, AKT1, HDAC4, INS, IGF1, IGF2, PRKACA, MTOR, INSR, IRS1, ARNT, AKT2 481 30 13528 10.3124 1.78E-04 4.79E-07 8.47E-05 precursor metabolites and energy
GO:0030522~intracellular 4.60E-08 AR, RARG, RXRA, ESR1, RB1, ESR2, DAXX, PPARGC1A, BRCA1, NR1H2, ALDH1A2, VDR, 481 75 13528 5.999945 1.79E-04 4.81E-07 8.52E-05 receptor-mediated signaling pathway CCNE1, RARA, JAK2, MED1
GO:0046328~regulation of JNK cascade 4.81E-08 TNF, MAP4K1, TLR4, PDCD4, DAXX, TP73, AKT1, MEN1, MAP3K7, NOD2, HIPK2, AKT2, SYK, 481 65 13528 6.490325 1.87E-04 5.01E-07 8.91E-05
AXIN1, CBS
GO:0006606~protein import into nucleus 4.82E-08 XPO1, TNF, HTT, TP53, TGFB3, FGF10, GLI3, TGFB1, TGFB2, AKT1, MAPK1, JUN, TSC2, SPTBN1, 481 86 13528 5.559542 1.87E-04 5.01E-07 8.92E-05
JAK2, FGF2, F2R
GO:0051259~protein oligomerization 5.28E-08 HRAS, CAV1, BLM, GRB2, TP53, PRKAB1, TP63, FADD, IRS1, GCH1, JUP, TNFRSF1A, IGF1R, 481 174 13528 3.879275 2.05E-04 5.47E-07 9.78E-05
NOD2, TSC1, VCP, BAX, ILK, TSC2, CASP8, FAS, PRNP, INSR, EIF2AK3
GO:0032946~positive regulation of 5.63E-08 PTPRC, IL2RA, BLM, EFNB1, CSF1, IL18, STAT5A, STAT5B, IL13, ADA, PRKCQ, CDKN1A, ZAP70, 481 56 13528 7.031185 2.19E-04 5.82E-07 1.04E-04 mononuclear cell proliferation SYK
GO:0009612~response to mechanical 5.63E-08 BMP4, CAV1, BMP2, TNF, TGFBR2, MMP14, STAT1, FOXP2, FOS, JUN, MKKS, COL1A1, GFI1, 481 56 13528 7.031185 2.19E-04 5.82E-07 1.04E-04 stimulus MYC
GO:0070665~positive regulation of 5.63E-08 PTPRC, IL2RA, BLM, EFNB1, CSF1, IL18, STAT5A, STAT5B, IL13, ADA, PRKCQ, CDKN1A, ZAP70, 481 56 13528 7.031185 2.19E-04 5.82E-07 1.04E-04 leukocyte proliferation SYK
GO:0042472~inner ear morphogenesis 5.63E-08 MYO6, MAFB, FGF10, COL2A1, PAX2, HOXA1, EYA1, CHD7, DLX6, DLX5, SIX1, FOXG1, GBX2, 481 56 13528 7.031185 2.19E-04 5.82E-07 1.04E-04
GFI1
GO:0048589~developmental growth 5.71E-08 BMP4, NBN, IGF1, FGF10, BRCA2, GLI2, GLI3, AKT1, CCNE1, PRKCQ, NOTCH1, PSEN1, PAX7, 481 87 13528 5.495639 2.22E-04 5.89E-07 1.06E-04
BCL2, PSEN2, BMPR1B, PLAU
GO:0051051~negative regulation of 5.81E-08 TNF, NOS1, ERBB3, DRD2, SNCA, FST, PTGS1, IGF2, NFKB1, ITGB3, FOXP3, PTEN, ADA, TGFB1, 481 135 13528 4.37496 2.26E-04 5.98E-07 1.08E-04 transport NR1H2, AKT1, INS, BCL2, NOS3, NRG1, INSR, AKT2
GO:0048610~reproductive cellular process 6.32E-08 BMP4, BBS4, SMAD5, PRKDC, BRCA2, KIT, WT1, TGFB1, AKT1, ACVR2A, CCND1, CXCR4, BAX, 481 162 13528 3.993019 2.46E-04 6.48E-07 1.17E-04
BCL2, NKX2-1, MKKS, FBXO5, FOXC1, PAFAH1B1, MTOR, OCA2, AXIN1, ACVR1
GO:0007611~learning or memory 6.51E-08 EGR1, HRAS, EGR2, HTT, DRD2, GRIN1, KIT, ESR2, PARK2, PTEN, EPHB2, FOXP2, FOS, BDNF, 481 111 13528 4.814145 2.53E-04 6.66E-07 1.21E-04
PSEN1, JUN, PSEN2, PAFAH1B1, SNAP25
GO:0008637~apoptotic mitochondrial 6.53E-08 BID, AKT1, CDKN2A, JUN, BCL2, BAX, TP53, SMAD3, SFN, MYC, TP73 481 31 13528 9.979746 2.54E-04 6.67E-07 1.21E-04 changes
GO:0001701~in utero embryonic 6.55E-08 AR, NBN, CEBPB, TP53, TGFB3, BRCA2, SMAD2, CAPN2, SRF, GLI3, ADA, ARNT, CITED2, HES1, 481 176 13528 3.835192 2.55E-04 6.66E-07 1.21E-04 development ACVR1B, CHD7, HSF1, COL4A3BP, GATA4, PDGFRB, FOXC1, ERCC2, ACVR1, MED1
GO:0051170~nuclear import 6.76E-08 XPO1, TNF, HTT, TP53, TGFB3, FGF10, GLI3, TGFB1, TGFB2, AKT1, MAPK1, JUN, TSC2, SPTBN1, 481 88 13528 5.433188 2.63E-04 6.86E-07 1.25E-04
JAK2, FGF2, F2R
GO:0017015~regulation of transforming 6.82E-08 CDKN1C, MEN1, HIPK2, SMAD4, TGFB3, ADAM17, SMAD3, SMAD2, ZEB1, ENG, TGFB1, CITED2 481 39 13528 8.653766 2.65E-04 6.91E-07 1.26E-04 growth factor beta receptor signaling pathway
GO:0007276~gamete generation 6.93E-08 BBS4, LEPR, FST, PRKDC, TBP, KIT, WT1, TGFB1, AKT1, HSF1, CXCR4, BCL2, MKKS, QKI, 481 395 13528 2.705671 2.69E-04 6.99E-07 1.28E-04
FBXO5, NOS3, H2AFX, PAFAH1B1, SPATA5, OCA2, AXIN1, BMP4, HTT, SMAD5, LMNA, BRCA2,
SMAD1, SIRT1, ACVR2A, NOTCH1, PLA2G4A, BAX, FOXC1, MTOR, BMPR1B, UTP14C, XRN2,
ACVR1
GO:0010565~regulation of cellular ketone 7.06E-08 CAV1, STK11, SNCA, PPARG, PRKAB1, IGF2, IRS1, PPARGC1A, BRCA1, NR1H2, AKT1, PLA2G4A, 481 57 13528 6.907831 2.74E-04 7.11E-07 1.31E-04 metabolic process INS, MTOR, AKT2
GO:0051222~positive regulation of 7.23E-08 BMP4, ACHE, TNF, TGFB3, SMAD4, SMAD3, IL13, IGF2, GLI3, TGFB1, TGFB2, PRKCQ, NOD2, 481 67 13528 6.296584 2.81E-04 7.27E-07 1.34E-04 protein transport INS, JAK2, PRKACA
GO:0030501~positive regulation of bone 7.58E-08 BMP4, ACVR2A, PLA2G4A, BMP2, TGFB3, SMAD3, BMPR1B, TGFB1, ACVR1 481 18 13528 14.06237 2.95E-04 7.60E-07 1.40E-04 mineralization
GO:0032869~cellular response to insulin 8.82E-08 ERBB3, GRB2, RXRA, PPARG, PRKDC, IGF2, STAT1, IRS1, AKT1, IGF1R, PDPK1, INS, FOXC2, 481 68 13528 6.203987 3.43E-04 8.81E-07 1.63E-04 stimulus INSR, AKT2, GHR
GO:0009617~response to bacterium 8.86E-08 TNF, STAT5B, SNCA, FASLG, TLR4, GCH1, FOS, TNFRSF1A, NOD2, MYD88, HSF1, NKX2-1, 481 193 13528 3.643101 3.44E-04 8.83E-07 1.64E-04
NOS3, SELP, SOCS1, STAT1, MAPK1, PLA2G4A, THBD, JUN, MAPK14, PLCG2, ADAM17, WASL,
F2R
GO:0051223~regulation of protein 9.93E-08 BMP4, ACHE, TNF, DRD2, TGFB3, SMAD4, SMAD3, IL13, IGF2, FOXP3, SIRT1, GLI3, TGFB1, 481 114 13528 4.687457 3.86E-04 9.87E-07 1.84E-04 transport TGFB2, PRKCQ, NOD2, INS, JAK2, PRKACA, MBTPS1
GO:0045669~positive regulation of 1.02E-07 MEN1, BMP4, ACVR2A, BMP2, DLX5, SMAD5, SMAD1, BMPR1B, RUNX2, ACVR1 481 25 13528 11.2499 3.96E-04 1.01E-06 1.89E-04 osteoblast differentiation
GO:0043280~positive regulation of 1.09E-07 TNF, TP53, SMAD3, STAT1, MEN1, CDKN2A, VCP, CASP9, BAX, APAF1, EIF2AK3, MYC, HIP1, 481 59 13528 6.673667 4.25E-04 1.08E-06 2.03E-04 caspase activity F2R
GO:0010952~positive regulation of 1.09E-07 TNF, TP53, SMAD3, STAT1, MEN1, CDKN2A, VCP, CASP9, BAX, APAF1, EIF2AK3, MYC, HIP1, 481 59 13528 6.673667 4.25E-04 1.08E-06 2.03E-04 peptidase activity F2R
GO:0009411~response to UV 1.09E-07 EGFR, HUS1, TP53, BRCA2, AKT1, MEN1, CCND1, CDKN1A, CASP9, BAX, BCL2, CDKN2D, 481 59 13528 6.673667 4.25E-04 1.08E-06 2.03E-04
MAPK8, ERCC2
GO:0050769~positive regulation of 1.09E-07 XRCC5, BMP2, LYN, DRD2, PPARG, DLL3, PAX6, SMAD1, KIT, EPHB2, NOTCH1, ILK, FOXG1, 481 59 13528 6.673667 4.25E-04 1.08E-06 2.03E-04 neurogenesis NGFR
GO:0070169~positive regulation of 1.27E-07 BMP4, ACVR2A, PLA2G4A, BMP2, TGFB3, SMAD3, BMPR1B, TGFB1, ACVR1 481 19 13528 13.32225 4.93E-04 1.25E-06 2.35E-04 biomineral formation
GO:0048483~autonomic nervous system 1.27E-07 HES1, HOXA1, EDNRB, HOXB1, RET, EGR2, ERBB2, GBX2, TP63 481 19 13528 13.32225 4.93E-04 1.25E-06 2.35E-04 development
GO:0007569~cell aging 1.28E-07 HRAS, CDKN2A, HTT, BCL2, ILK, TP53, TP63, BRCA2, PDCD4, SIRT1, ENG 481 33 13528 9.374913 4.97E-04 1.26E-06 2.37E-04
GO:0010038~response to metal ion 1.37E-07 EGFR, CAV1, HTT, RXRA, SLC6A3, SNCA, LEF1, PTEN, AQP3, ATP7A, CCND1, PLA2G4A, EP300, 481 129 13528 4.360425 5.33E-04 1.35E-06 2.54E-04
BCL2, PLCG2, MAPK9, NOS3, MAPK8, PRNP, INSR
GO:0050863~regulation of T cell 1.49E-07 PTPRC, IL2RA, BLM, EFNB1, STAT5A, ERBB2, IL18, STAT5B, TGFBR2, ZEB1, FOXP3, ADA, 481 117 13528 4.567265 5.80E-04 1.46E-06 2.76E-04 activation TGFB1, MAP3K7, PRKCQ, CDKN2A, ZAP70, RARA, SYK
GO:0002573~myeloid leukocyte 1.76E-07 TNF, PSEN1, MMP9, CSF1, PSEN2, PPARG, TGFBR2, CASP8, KIT, CHUK, TGFB1 481 34 13528 9.099181 6.82E-04 1.71E-06 3.25E-04 differentiation
GO:0021904~dorsal/ventral neural tube 1.87E-07 BMP4, GSC, PSEN1, FOXA2, PAX7, PSEN2, MNX1, GLI2 481 14 13528 16.07128 7.28E-04 1.83E-06 3.47E-04 patterning
GO:0042129~regulation of T cell 2.04E-07 PTPRC, IL2RA, BLM, ERBB2, IL18, STAT5A, EFNB1, STAT5B, FOXP3, TGFB1, PRKCQ, CDKN2A, 481 62 13528 6.350748 7.91E-04 1.98E-06 3.77E-04 proliferation ZAP70, SYK
GO:0032570~response to progesterone 2.05E-07 CCNE1, FOS, CAV1, ERBB4, ERBB2, SOCS1, TGFB3, TGFB1, TGFB2 481 20 13528 12.65613 7.97E-04 1.99E-06 3.80E-04 stimulus
GO:0007411~axon guidance 2.05E-07 EGR2, EFNB1, ERBB2, PAX6, GLI2, EPHB2, HOXA1, BDNF, HOXA2, CXCR4, FOXG1, GBX2, 481 107 13528 4.731265 7.98E-04 1.98E-06 3.80E-04
NKX2-1, EFNA5, NGFR, BMPR1B, RUNX3, ETV4 GO:0033365~protein localization in 2.18E-07 BID, XPO1, BBS4, TNF, HTT, TP53, TGFB3, PAX6, FGF10, GLI3, TGFB1, TGFB2, AKT1, MAPK1, 481 146 13528 4.045339 8.47E-04 2.10E-06 4.04E-04 organelle JUN, TSC2, SPTBN1, JAK2, FGF2, F2R, NR5A1
GO:0051969~regulation of transmission of 2.44E-07 EGFR, EGR1, HRAS, ACHE, TNF, EGR2, MYO6, ERBB4, HTT, DRD2, GRIN1, SNCA, KIT, PARK2, 481 147 13528 4.01782 9.49E-04 2.35E-06 4.52E-04 nerve impulse EPHB2, BDNF, PSEN1, APOE, PSEN2, PRKACA, EIF2AK3
GO:0001889~liver development 2.46E-07 RXRA, ERBB2, STAT5B, ADA, CITED2, HES1, ALDH1A2, HHEX, CCNE1, NOTCH1, CCND1, 481 53 13528 6.898521 9.57E-04 2.36E-06 4.56E-04
EP300, MED1
GO:0045619~regulation of lymphocyte 2.48E-07 PTPRC, IL2RA, ERBB2, STAT5A, STAT5B, TGFBR2, ZEB1, ADA, CDKN2A, ZAP70, RARA, INPP5D, 481 63 13528 6.249942 9.65E-04 2.38E-06 4.60E-04 differentiation FAS, SYK
GO:0051271~negative regulation of cell 2.48E-07 GTPBP4, NF2, DRD2, PTEN, TGFB1, ADA, VCL, CITED2, CDKN1B, APOE, BCL2, ILK, CHRD, FGF2 481 63 13528 6.249942 9.65E-04 2.38E-06 4.60E-04 motion
GO:0048871~multicellular organismal 2.62E-07 BBS4, ERBB4, DRD2, CSF1, PTH1R, COL2A1, PPARGC1A, STAT3, KDR, PTHLH, PLA2G4A, BAX, 481 85 13528 5.294069 0.001017 2.50E-06 4.85E-04 homeostasis BCL2, VEGFA, PDGFRB, F2R
GO:0006260~DNA replication 2.69E-07 CDC7, SSRP1, ACHE, BLM, POLG, LIN9, HUS1, IGF1, BRCA2, ATR, MCM2, CDC25C, SIRT1, 481 190 13528 3.552599 0.001047 2.57E-06 4.99E-04
RAD50, BRCA1, CDC25A, CDK2, TK1, DKC1, CTGF, CDKN2D, TOP2A, TERT, MED1
GO:0048167~regulation of synaptic 3.02E-07 EGR1, HRAS, EGR2, MYO6, DRD2, HTT, SNCA, GRIN1, KIT, EPHB2, BDNF, PSEN1, APOE, PSEN2 481 64 13528 6.152287 0.001172 2.87E-06 5.59E-04 plasticity
GO:0006919~activation of caspase 3.07E-07 TNF, TP53, SMAD3, STAT1, CDKN2A, VCP, CASP9, BAX, APAF1, EIF2AK3, MYC, HIP1, F2R 481 54 13528 6.770771 0.001191 2.91E-06 5.68E-04 activity
GO:0021983~pituitary gland development 3.13E-07 HES1, BMP4, ALDH1A2, EYA1, DRD2, SLC6A3, PAX6, NKX2-1, GLI2, PITX1 481 28 13528 10.04455 0.001216 2.96E-06 5.80E-04
GO:0002260~lymphocyte homeostasis 3.13E-07 AKT1, IL2RA, BCL2, STAT5A, BAX, STAT5B, FAS, IKBKB, FOXP3, TGFB1 481 28 13528 10.04455 0.001216 2.96E-06 5.80E-04
GO:0001776~leukocyte homeostasis 3.19E-07 MEN1, AKT1, IL2RA, BCL2, STAT5A, BAX, STAT5B, FAS, IKBKB, FOXP3, TGFB1 481 36 13528 8.593671 0.00124 3.01E-06 5.91E-04
GO:0050804~regulation of synaptic 3.21E-07 EGFR, EGR1, HRAS, ACHE, TNF, EGR2, MYO6, ERBB4, HTT, DRD2, SNCA, GRIN1, KIT, PARK2, 481 136 13528 4.135991 0.001246 3.02E-06 5.94E-04 transmission EPHB2, BDNF, PSEN1, APOE, PSEN2, PRKACA
GO:0043029~T cell homeostasis 3.21E-07 AKT1, IL2RA, BCL2, STAT5A, BAX, STAT5B, FAS, FOXP3, TGFB1 481 21 13528 12.05346 0.001247 3.01E-06 5.95E-04
GO:0001836~release of cytochrome c 3.21E-07 BID, JUN, BCL2, BAX, TP53, SMAD3, SFN, MYC, TP73 481 21 13528 12.05346 0.001247 3.01E-06 5.95E-04 from mitochondria GO:0045884~regulation of survival gene 3.21E-07 MEF2C, AKT1, STAT5A, BAX, STAT5B, ESR1, ESR2, NKX2-5, MYC 481 21 13528 12.05346 0.001247 3.01E-06 5.95E-04 product expression
GO:0006979~response to oxidative stress 3.47E-07 EGFR, ERBB4, SNCA, PTGS1, TLR4, MMP14, STAT1, ADA, ARNT, ATP7A, FOS, PLA2G4A, EP300, 481 164 13528 3.772831 0.001347 3.25E-06 6.43E-04
PSEN1, APOE, JUN, BCL2, JAK2, COL1A1, PRNP, ERCC2, HDAC6
GO:0035113~embryonic appendage 3.59E-07 WNT5A, NOG, RARG, TP63, LEF1, GLI3, ALDH1A2, NOTCH1, CHD7, PSEN1, DLX6, DLX5, PSEN2, 481 87 13528 5.172366 0.001395 3.36E-06 6.65E-04 morphogenesis PBX1, RARB, MED1
GO:0030326~embryonic limb 3.59E-07 WNT5A, NOG, RARG, TP63, LEF1, GLI3, ALDH1A2, NOTCH1, CHD7, PSEN1, DLX6, DLX5, PSEN2, 481 87 13528 5.172366 0.001395 3.36E-06 6.65E-04 morphogenesis PBX1, RARB, MED1
GO:0002076~osteoblast development 3.60E-07 MEN1, PTHLH, HOXA2, ACHE, PTH1R, SMAD3, GLI2 481 10 13528 19.68732 0.001398 3.35E-06 6.67E-04
GO:0030855~epithelial cell differentiation 3.60E-07 LOR, ELF3, FOXA2, PPARG, PAX6, TP63, SFN, FZD2, PAX2, WT1, KDR, PTHLH, DLX6, JUN, 481 137 13528 4.105801 0.0014 3.35E-06 6.68E-04
DLX5, POU2F3, VEGFA, SIX1, NKX2-1, ENG
GO:0051345~positive regulation of 3.76E-07 EGFR, TNF, CCKBR, DRD2, PTH1R, TP53, SMAD3, STAT1, NR1H2, MEN1, EDNRB, CDKN2A, 481 179 13528 3.613793 0.001461 3.49E-06 6.97E-04 hydrolase activity TSC1, VCP, CASP9, BAX, TSC2, JAK2, APAF1, EIF2AK3, MYC, F2R, HIP1
GO:0050671~positive regulation of 3.80E-07 PTPRC, IL2RA, BLM, IL18, STAT5A, EFNB1, STAT5B, IL13, ADA, PRKCQ, CDKN1A, ZAP70, SYK 481 55 13528 6.647666 0.001475 3.51E-06 7.03E-04 lymphocyte proliferation
GO:0009416~response to light stimulus 4.05E-07 EGFR, HRAS, HTT, DRD2, HUS1, GRIN1, TP53, BRCA2, KIT, AKT1, MEN1, FOS, CCND1, CDKN1A, 481 138 13528 4.076049 0.001571 3.73E-06 7.49E-04
CASP9, BAX, BCL2, CDKN2D, MAPK8, ERCC2
GO:0021536~diencephalon development 4.24E-07 HES1, BMP4, ALDH1A2, EYA1, DRD2, SLC6A3, BAX, PAX6, NKX2-1, GLI2, PITX1 481 37 13528 8.361409 0.001645 3.90E-06 7.85E-04
GO:0021543~pallium development 4.34E-07 BBS4, PSEN1, TSC1, BAX, GRIN1, PAX6, NKX2-1, LEF1, MKKS, PAFAH1B1, GLI3, TP73 481 46 13528 7.336889 0.001684 3.98E-06 8.03E-04
GO:0043393~regulation of protein binding 4.40E-07 HDAC4, GTPBP4, NOG, PSEN1, BCL2, BAX, ATR, NRG1, EIF2AK3, PRKCD 481 29 13528 9.698186 0.001707 4.03E-06 8.15E-04
GO:0010769~regulation of cell 4.48E-07 GRIN1, TGFB3, SMAD4, SMAD3, SMAD2, SMAD1, TGFB1, TGFB2, EPHB2, PTK2, PSEN1, APOE, 481 77 13528 5.478845 0.001742 4.10E-06 8.31E-04 morphogenesis involved in differentiation ILK, NGFR, SPP1
GO:0007281~germ cell development 4.88E-07 BMP4, BBS4, SMAD5, BRCA2, KIT, WT1, AKT1, CXCR4, BAX, BCL2, FBXO5, MKKS, PAFAH1B1, 481 101 13528 4.733867 0.001895 4.45E-06 9.04E-04
MTOR, OCA2, AXIN1, ACVR1
GO:0010564~regulation of cell cycle 5.23E-07 CDC7, PTPRC, XPO1, TNF, IGF1, BRCA2, BIRC5, IGF2, RB1, CDC25C, BRCA1, TGFB1, PRKCQ, 481 114 13528 4.440748 0.00203 4.76E-06 9.69E-04 process CDKN2A, INS, FBXO5, TGFA, INSR, APC GO:0032147~activation of protein kinase 5.23E-07 EGFR, TGFBR2, SPHK1, MAP4K1, IGF2, TGFB2, MAP3K7, PDPK1, PSEN1, PRLR, INS, PRKACA, 481 114 13528 4.440748 0.00203 4.76E-06 9.69E-04 activity JAK2, CERK, NRG1, INSR, FGF2, F2R, GHR
GO:0051384~response to glucocorticoid 5.29E-07 BMP4, CAV1, TNF, RXRA, PTGS1, FOS, CCNE1, CCND1, PLA2G4A, CDKN1A, EP300, BCL2, FAS, 481 78 13528 5.408604 0.002054 4.81E-06 9.80E-04 stimulus INSR, GHR
GO:0030336~negative regulation of cell 5.74E-07 GTPBP4, NF2, DRD2, PTEN, TGFB1, ADA, VCL, CITED2, APOE, BCL2, ILK, CHRD, FGF2 481 57 13528 6.414414 0.002228 5.20E-06 0.001063 migration
GO:0046620~regulation of organ growth 6.09E-07 MEN1, NOG, PTK2, GATA4, TGFBR2, FOXC2, FOXC1, RAG2, NRG1, FGF2 481 30 13528 9.374913 0.002362 5.50E-06 0.001127
GO:0030500~regulation of bone 6.09E-07 BMP4, ACVR2A, PLA2G4A, BMP2, TGFB3, SMAD3, SOX9, BMPR1B, TGFB1, ACVR1 481 30 13528 9.374913 0.002362 5.50E-06 0.001127 mineralization
GO:0032388~positive regulation of 6.09E-07 BMP4, PRKCQ, TNF, SMAD4, TGFB3, SMAD3, JAK2, PRKACA, GLI3, TGFB1 481 30 13528 9.374913 0.002362 5.50E-06 0.001127 intracellular transport
GO:0051090~regulation of transcription 6.42E-07 TNF, TLR4, FOXP3, SIRT1, TGFB1, PTHLH, MEN1, HDAC4, PRKCQ, NOD2, CDKN2A, EP300, 481 103 13528 4.641947 0.002492 5.79E-06 0.001189 factor activity MYD88, ID1, PBX1, JAK2, IKBKB
GO:0007267~cell-cell signaling 6.87E-07 WNT5A, ACHE, DRD2, GRB2, IL18, SNCA, IL13, TP63, FASLG, FGF10, GLI2, TGFB2, BDNF, PTK2, 481 600 13528 2.203105 0.002667 6.18E-06 0.001273
INS, APOE, GATA4, POU2F1, NKX2-1, PAFAH1B1, FGF2, SNAP25, SYK, BMP4, BMP2, AR, MYO6,
NOS1, LYN, HTT, EFNB1, GRIN1, IGF2, SMAD2, ESR2, FZD2, PARK2, PTHLH, MAPK1, CAMK4,
GO:0035282~segmentation 6.89E-07 HOXA2, EP300, EGR2, PSEN1, MEOX2, MAFB, PSEN2, MYF5, DLL3, PRKDC, LEF1, ROR2 481 48 13528 7.031185 0.002673 6.18E-06 0.001276
GO:0046822~regulation of 7.01E-07 BMP4, TNF, TGFB3, SMAD4, SMAD3, GLI3, SIRT1, TGFB1, PRKCQ, CDKN2A, PRKACA, JAK2, 481 58 13528 6.303821 0.002719 6.27E-06 0.001298 nucleocytoplasmic transport MBTPS1
GO:0055082~cellular chemical 7.02E-07 CAV1, DRD2, ERBB2, PTH1R, SNCA, CXCR3, TGFB1, VDR, EDNRB, CXCR4, APOE, BCL2, ILK, 481 380 13528 2.590437 0.002723 6.27E-06 0.0013 homeostasis QKI, MYC, ERCC2, PTPRC, EGR2, CCKBR, HTT, GRIN1, TP53, FZD2, PPARGC1A, ATP7A, TSC1,
PSEN1, JUN, BAX, PLCG2, MT2A, EPOR, JAK2, PRNP, F2R
GO:0042475~odontogenesis of 7.25E-07 BMP4, BMP2, NF2, BAX, FST, LEF1, TP63, FOXC1, GLI2, GLI3, CHUK 481 39 13528 7.932619 0.002816 6.47E-06 0.001344 dentine-containing tooth
GO:0007259~JAK-STAT cascade 7.25E-07 STAT4, PRLR, NLK, STAT5A, SOCS1, STAT5B, JAK2, STAT1, STAT3, F2R, GHR 481 39 13528 7.932619 0.002816 6.47E-06 0.001344
GO:0048592~eye morphogenesis 7.55E-07 BMP4, BBS4, RARG, PAX6, FASLG, ZEB1, GLI3, STAT3, EPHB2, BAX, VEGFA, POU2F1, GDF11, 481 69 13528 5.706469 0.002931 6.72E-06 0.001399 RARB
GO:0045648~positive regulation of 7.68E-07 ACVR2A, TAL1, ACVR1B, ETS1, MAPK14, INPP5D, ARNT 481 11 13528 17.89756 0.002981 6.82E-06 0.001423 erythrocyte differentiation
GO:0051100~negative regulation of 8.51E-07 GTPBP4, NOG, FOXP3, PRKCD, SIRT1, PTHLH, MEN1, HDAC4, NOD2, CDKN2A, ID1, PBX1, JAK2 481 59 13528 6.196977 0.003304 7.54E-06 0.001577 binding
GO:0051896~regulation of protein kinase 9.68E-07 INS, DRD2, ILK, TSC2, IGF2, MTOR, INSR, PTEN, TGFB1 481 17 13528 13.23517 0.003755 8.55E-06 0.001793
B signaling cascade
GO:0019953~sexual reproduction 1.01E-06 BBS4, LEPR, FST, PRKDC, TBP, KIT, WT1, TGFB1, AKT1, HSF1, CXCR4, BCL2, MKKS, QKI, 481 458 13528 2.394901 0.003929 8.93E-06 0.001876
FBXO5, NOS3, PAFAH1B1, H2AFX, SPATA5, OCA2, AXIN1, BMP4, HTT, SMAD5, LMNA, BRCA2,
SMAD1, SIRT1, STAT3, ACVR2A, NOTCH1, PLA2G4A, BAX, FOXC1, MTOR, BMPR1B, UTP14C,
XRN2, ACVR1
GO:0010770~positive regulation of cell 1.09E-06 SMAD4, TGFB3, SMAD3, SMAD2, TGFB1, TGFB2 481 7 13528 24.10692 0.004231 9.59E-06 0.002021 morphogenesis involved in differentiation
GO:0010718~positive regulation of 1.09E-06 SMAD4, TGFB3, SMAD3, SMAD2, TGFB1, TGFB2 481 7 13528 24.10692 0.004231 9.59E-06 0.002021 epithelial to mesenchymal transition
GO:0021546~rhombomere development 1.09E-06 HOXA1, HOXB1, HOXA2, EGR2, MAFB, GBX2 481 7 13528 24.10692 0.004231 9.59E-06 0.002021
GO:0070167~regulation of biomineral 1.12E-06 BMP4, ACVR2A, PLA2G4A, BMP2, TGFB3, SMAD3, SOX9, BMPR1B, TGFB1, ACVR1 481 32 13528 8.788981 0.004343 9.82E-06 0.002074 formation
GO:0001570~vasculogenesis 1.20E-06 CAV1, PTK2, VEGFA, TGFBR2, QKI, ENG, NKX2-5, RASA1, WT1, CITED2, KDR 481 41 13528 7.545662 0.004654 1.05E-05 0.002223
GO:0042692~muscle cell differentiation 1.24E-06 BMP4, HRAS, NOS1, RXRA, ERBB2, IGF1, FGF10, RB1, CAPN2, SYNE1, TSC1, QKI, RARB, NRG1, 481 121 13528 4.183846 0.004793 1.08E-05 0.00229
NKX2-5, PITX1, F2R, ACVR1
GO:0040013~negative regulation of 1.24E-06 GTPBP4, NF2, DRD2, PTEN, TGFB1, ADA, VCL, CITED2, APOE, BCL2, ILK, CHRD, FGF2 481 61 13528 5.993797 0.004817 1.08E-05 0.002301 locomotion
GO:0043062~extracellular structure 1.31E-06 ACHE, MYO6, ELF3, ERBB4, LGALS3, DRD2, MMP9, ERBB2, MYF5, COL2A1, TGFB2, ATP7A, 481 163 13528 3.623433 0.005076 1.14E-05 0.002426 organization PTK2, TSC1, ILK, FOXC2, FOXC1, COL1A1, ENG, F2R, ERCC2
GO:0050864~regulation of B cell 1.32E-06 STAT6, PTPRC, CDKN1A, CDKN2A, STAT5A, STAT5B, IL13, FAS, INPP5D, ADA, TGFB1, SYK 481 51 13528 6.617586 0.005111 1.14E-05 0.002442 activation
GO:0045580~regulation of T cell 1.32E-06 PTPRC, CDKN2A, IL2RA, ERBB2, STAT5A, STAT5B, TGFBR2, ZAP70, RARA, ZEB1, ADA, SYK 481 51 13528 6.617586 0.005111 1.14E-05 0.002442 differentiation
GO:0055066~di-, tri-valent inorganic 1.33E-06 CAV1, DRD2, PTH1R, CXCR3, TGFB1, VDR, EDNRB, CXCR4, APOE, BCL2, MYC, PTPRC, CCKBR, 481 239 13528 3.059595 0.005153 1.15E-05 0.002462 cation homeostasis HTT, GRIN1, FZD2, KDR, ATP7A, PSEN1, BAX, MT2A, PLCG2, JAK2, EPOR, PRNP, F2R
GO:0006952~defense response 1.36E-06 TNF, S100A8, ELF3, STAT5B, SNCA, PPARG, IL13, TLR4, NFKB1, TGFB1, GCH1, AKT1, 481 615 13528 2.14937 0.005257 1.17E-05 0.002512
TNFRSF1A, FOS, NOD2, TNFRSF1B, MYD88, CD44, HSF1, CXCR4, INS, BCL2, GATA3, NFATC4,
NFATC3, SPP1, SELP, PTPRC, BMP2, IL2RA, CEBPB, LYN, RXRA, CSNK2B, IGF2, SMAD1, ESR2,
WAS, STAT
GO:0006873~cellular ion homeostasis 1.39E-06 CAV1, DRD2, ERBB2, PTH1R, SNCA, CXCR3, TGFB1, VDR, EDNRB, CXCR4, APOE, BCL2, ILK, 481 374 13528 2.556795 0.005404 1.20E-05 0.002583
QKI, MYC, ERCC2, PTPRC, EGR2, CCKBR, HTT, GRIN1, TP53, FZD2, ATP7A, TSC1, PSEN1, JUN,
BAX, PLCG2, MT2A, EPOR, JAK2, PRNP, F2R
GO:0048339~paraxial mesoderm 1.49E-06 HTT, DLL3, FOXC2, SMAD3, LEF1, SMAD2, FOXC1 481 12 13528 16.4061 0.005775 1.28E-05 0.00276 development
GO:0008630~DNA damage response, 1.49E-06 HIPK1, HIPK2, TP53, TP63, BRCA2, MBD4, SFN, ABL1, BRCA1, TP73 481 33 13528 8.522649 0.005781 1.28E-05 0.002763 signal transduction resulting in induction of apoptosis
GO:0050871~positive regulation of B cell 1.49E-06 STAT6, PTPRC, CDKN1A, STAT5A, STAT5B, IL13, INPP5D, ADA, TGFB1, SYK 481 33 13528 8.522649 0.005781 1.28E-05 0.002763 activation
GO:0048730~epidermis morphogenesis 1.50E-06 ATP7A, NOTCH1, BCL2, FST, TP63, NGFR, COL1A1, RUNX3, TGFB2 481 25 13528 10.12491 0.005832 1.29E-05 0.002788
GO:0033189~response to vitamin A 1.53E-06 BMP4, ALDH1A2, BMP2, RARG, CD44, CDKN2D, RXRA, PPARG, RARA, LRP2, AQP3 481 42 13528 7.366003 0.005913 1.30E-05 0.002826
GO:0007626~locomotory behavior 1.62E-06 HRAS, DRD2, SLC6A3, SNCA, FGF10, CXCR3, TGFB2, EDNRB, CHD7, HTRA2, CXCR4, NKX2-1, 481 274 13528 2.874061 0.006268 1.38E-05 0.002997
PAFAH1B1, FGF2, SYK, MYO6, HTT, GRIN1, PARK2, ATP7A, MAPK1, MAPK14, HIPK2, TSC2,
PDGFRB, ENG, TSHR, PLAU
GO:0002757~immune response-activating 1.62E-06 MAP3K7, MAPK1, PTPRC, NOD2, MYD88, PSEN1, LYN, PSEN2, PLCG2, ZAP70, TLR4, SYK 481 52 13528 6.490325 0.006274 1.38E-05 0.003 signal transduction GO:0001894~tissue homeostasis 1.78E-06 BBS4, ERBB4, CSF1, PTH1R, COL2A1, KDR, PTHLH, PLA2G4A, BAX, BCL2, VEGFA, PDGFRB, 481 63 13528 5.803518 0.00691 1.51E-05 0.003305
F2R
GO:0007005~mitochondrion organization 1.82E-06 BID, HTT, POLG, SNCA, TP53, SMAD3, SFN, PPARGC1A, TP73, AKT1, ATP7A, CDKN2A, HTRA2, 481 138 13528 3.872247 0.007058 1.54E-05 0.003376
JUN, BAX, BCL2, COL4A3BP, NOS3, MYC
GO:0033157~regulation of intracellular 1.98E-06 BMP4, PRKCQ, TNF, SMAD4, TGFB3, SMAD3, JAK2, PRKACA, SIRT1, MBTPS1, GLI3, TGFB1 481 53 13528 6.367866 0.007662 1.67E-05 0.003666 protein transport
GO:0010001~glial cell differentiation 1.98E-06 EGFR, NOTCH1, EGR2, LYN, CDKN2C, ERBB3, ERBB2, SOX11, NKX2-1, IGF1, FGF2, ERCC2 481 53 13528 6.367866 0.007662 1.67E-05 0.003666
GO:0035272~exocrine system 2.36E-06 EGFR, PAX6, TGFB3, SOX4, FGF10, FOXC1, TGFB1, TGFB2 481 19 13528 11.842 0.00912 1.99E-05 0.004366 development
GO:0031069~hair follicle morphogenesis 2.36E-06 ATP7A, NOTCH1, BCL2, FST, TP63, NGFR, RUNX3, TGFB2 481 19 13528 11.842 0.00912 1.99E-05 0.004366
GO:0010907~positive regulation of 2.36E-06 AKT1, INS, IGF1, IGF2, INSR, PPARGC1A, IRS1, ARNT, AKT2 481 19 13528 11.842 0.00912 1.99E-05 0.004366 glucose metabolic process
GO:0051402~neuron apoptosis 2.36E-06 BID, PSEN1, ERBB3, HTT, BCL2, BAX, TP63, APAF1 481 19 13528 11.842 0.00912 1.99E-05 0.004366
GO:0021545~cranial nerve development 2.36E-06 HES1, HOXA1, HOXB1, CHD7, EGR2, ERBB3, GLI3, EPHB2 481 19 13528 11.842 0.00912 1.99E-05 0.004366
GO:0042113~B cell activation 2.38E-06 PTPRC, NBN, RAG1, TP53, PRKDC, RAG2, PRKCD, ADA, HDAC4, BAX, BCL2, PLCG2, ADAM17, 481 76 13528 5.180873 0.009203 2.00E-05 0.004406
TSHR
GO:0050870~positive regulation of T cell 2.38E-06 PTPRC, IL2RA, BLM, IL18, STAT5A, EFNB1, STAT5B, TGFBR2, ADA, MAP3K7, PRKCQ, ZAP70, 481 76 13528 5.180873 0.009203 2.00E-05 0.004406 activation RARA, SYK
GO:0042306~regulation of protein import 2.41E-06 BMP4, PRKCQ, TNF, SMAD4, TGFB3, SMAD3, JAK2, SIRT1, MBTPS1, GLI3, TGFB1 481 44 13528 7.031185 0.009338 2.03E-05 0.004472 into nucleus
GO:0031016~pancreas development 2.56E-06 ALDH1A2, FOXA2, NKX3-2, GDF11, MNX1, SOX4, FGF10, NEUROD1, SMAD2, EIF2AK3 481 35 13528 8.03564 0.009915 2.15E-05 0.004749
GO:0045621~positive regulation of 2.56E-06 PTPRC, IL2RA, STAT5A, STAT5B, TGFBR2, ZAP70, RARA, INPP5D, ADA, SYK 481 35 13528 8.03564 0.009915 2.15E-05 0.004749 lymphocyte differentiation
GO:0010906~regulation of glucose 2.56E-06 AKT1, HDAC4, INS, IGF1, IGF2, MTOR, INSR, PPARGC1A, IRS1, ARNT, AKT2 481 35 13528 8.03564 0.009915 2.15E-05 0.004749 metabolic process
GO:0006955~immune response 2.67E-06 NBN, IL18, SNCA, PPARG, FASLG, IL13, TLR4, ZEB1, TGFB1, NOD2, MYD88, CXCR4, COL4A3BP, 481 690 13528 2.038025 0.010321 2.23E-05 0.004945 FAS, CHUK, IKBKAP, LYN, TP53, WAS, PRKCD, PSEN1, VEGFA, PSEN2, MNX1, ADAM17, LCP2,
TNF, RAG1, PRKDC, RAG2, ADA, GCH1, IGF1R, TNFRSF1A, TNFRSF1B, BCL2, ZAP70, INPP5D,
PTP
GO:0014066~regulation of 2.68E-06 ERBB3, INS, ERBB2, TSC2, IGF1, IGF2, JAK2, TGFB2 481 13 13528 15.14409 0.01038 2.24E-05 0.004973 phosphoinositide 3-kinase cascade
GO:0031344~regulation of cell projection 2.76E-06 BBS4, GRIN1, TGFB3, SMAD1, KIT, EPHB2, PRKCQ, PTK2, PSEN1, APOE, ILK, NGFR, MTOR, 481 89 13528 4.740125 0.010669 2.30E-05 0.005112 organization APC, SPP1
GO:0048340~paraxial mesoderm 2.82E-06 HTT, FOXC2, SMAD3, LEF1, SMAD2, FOXC1 481 8 13528 21.09356 0.010915 2.35E-05 0.005231 morphogenesis
GO:0050768~negative regulation of 3.01E-06 BMP4, BDNF, NOG, PTK2, PSEN1, DLL3, TP53, NGFR, TGFB1, EPHB2, SPP1 481 45 13528 6.874936 0.011617 2.49E-05 0.005569 neurogenesis
GO:0034470~ncRNA processing 3.04E-06 RPP38, RPP25, TBL3, UTP15, SMAD3, HEATR1, SMAD2, SMAD1, CDKN2A, WDR36, DKC1, 481 187 13528 3.308793 0.01175 2.51E-05 0.005633
NOLC1, POP1, WDR3, RPP30, POP4, POP5, UTP14A, TFB1M, IMP4, POP7, UTP14C
GO:0051099~positive regulation of 3.22E-06 TNF, TLR4, TGFB1, PRKCQ, HDAC4, NOD2, EP300, MYD88, HIPK2, JAK2, BRD4, IKBKB, 481 78 13528 5.04803 0.012434 2.66E-05 0.005963 binding EIF2AK3, ERCC2
GO:0010741~negative regulation of 3.31E-06 MEN1, AKT1, CAV1, NF2, DRD2, SOCS1, TSC2, TNFAIP3, PTEN, APC 481 36 13528 7.812428 0.01279 2.73E-05 0.006135 protein kinase cascade
GO:0002764~immune response-regulating 3.51E-06 MAP3K7, MAPK1, PTPRC, NOD2, MYD88, PSEN1, LYN, PSEN2, PLCG2, ZAP70, TLR4, SYK 481 56 13528 6.02673 0.013555 2.89E-05 0.006505 signal transduction
GO:0010676~positive regulation of 3.52E-06 AKT1, INS, IGF1, IGF2, INSR, PPARGC1A, IRS1, ARNT, AKT2 481 20 13528 11.2499 0.013573 2.88E-05 0.006513 cellular carbohydrate metabolic process
GO:0045913~positive regulation of 3.52E-06 AKT1, INS, IGF1, IGF2, INSR, PPARGC1A, IRS1, ARNT, AKT2 481 20 13528 11.2499 0.013573 2.88E-05 0.006513 carbohydrate metabolic process
GO:0060349~bone morphogenesis 3.52E-06 PTHLH, TGFB3, COL2A1, COL1A1, SOX9, RUNX2, TGFB1, GHR 481 20 13528 11.2499 0.013573 2.88E-05 0.006513
GO:0050801~ion homeostasis 3.66E-06 CAV1, DRD2, ERBB2, PTH1R, SNCA, CXCR3, TGFB1, VDR, EDNRB, CXCR4, APOE, BCL2, ILK, 481 409 13528 2.406763 0.014108 2.99E-05 0.006772
QKI, MYC, ERCC2, PTPRC, EGR2, CCKBR, HTT, GRIN1, TP53, FZD2, KDR, ATP7A, TSC1, PSEN1, JUN, BAX, PLCG2, MT2A, EPOR, JAK2, PRNP, F2R
GO:0030111~regulation of Wnt receptor 3.72E-06 CTNNBIP1, HHEX, CCND1, GSC, NLK, TSC2, SOX4, LEF1, FGF10, AXIN1, APC 481 46 13528 6.725481 0.014358 3.04E-05 0.006893 signaling pathway
GO:0045834~positive regulation of lipid 3.72E-06 NR1H2, AKT1, PLA2G4A, TNF, INS, APOE, PPARG, IGF2, PPARGC1A, IRS1, TGFB1, AKT2 481 46 13528 6.725481 0.014358 3.04E-05 0.006893 metabolic process
GO:0022604~regulation of cell 3.78E-06 GRIN1, TGFB3, SMAD4, SMAD3, SMAD2, SMAD1, TGFB1, TGFB2, KDR, EPHB2, PTK2, PSEN1, 481 131 13528 3.864468 0.014575 3.08E-05 0.006997 morphogenesis APOE, ILK, VEGFA, NGFR, RASA1, SPP1
GO:0017038~protein import 3.78E-06 BID, XPO1, TNF, HTT, TP53, TGFB3, FGF10, GLI3, TGFB1, TGFB2, AKT1, MAPK1, JUN, TSC2, 481 131 13528 3.864468 0.014575 3.08E-05 0.006997
SPTBN1, JAK2, FGF2, F2R
GO:0045740~positive regulation of DNA 3.94E-06 IGF1R, HRAS, INS, JUN, TGFB3, IGF1, KITLG, IGF2, GLI2, INSR 481 28 13528 9.040095 0.015184 3.20E-05 0.007292 replication
GO:0008156~negative regulation of DNA 3.94E-06 GTPBP4, BLM, NF2, HUS1, TGFB3, TP53, BRCA2, ATR, TGFB1 481 28 13528 9.040095 0.015184 3.20E-05 0.007292 replication
GO:0019725~cellular homeostasis 3.99E-06 CAV1, DRD2, ERBB2, PTH1R, SNCA, CXCR3, SRF, TGFB1, VDR, EDNRB, CXCR4, APOE, BCL2, 481 466 13528 2.293434 0.015407 3.24E-05 0.0074
ILK, QKI, APEX1, MYC, ERCC2, APC, PTPRC, EGR2, CCKBR, HTT, GRIN1, TP53, FZD2,
PPARGC1A, ATP7A, TSC1, PSEN1, JUN, BAX, PLCG2, MT2A, EPOR, JAK2, PRNP, F2R
GO:0032330~regulation of chondrocyte 4.56E-06 PTHLH, BMP4, THRB, SOX9, GLI2, RUNX2, GLI3 481 14 13528 14.06237 0.017558 3.69E-05 0.008442 differentiation
GO:0051302~regulation of cell division 4.58E-06 MEN1, BBS4, BLM, INS, VEGFA, TGFB3, TGFA, IGF2, FGF2, TGFB1, TGFB2, APC 481 47 13528 6.582386 0.017638 3.70E-05 0.008481
GO:0016331~morphogenesis of 5.04E-06 MAP3K7, BBS4, ALDH1A2, RET, TSC1, HTT, TSC2, CASP8, TFAP2A, APAF1, PAX3, GLI2 481 58 13528 5.818912 0.019384 4.06E-05 0.009329 embryonic epithelium
GO:0070304~positive regulation of 5.11E-06 MAP3K7, NOD2, TNF, LYN, HIPK2, TLR4, AXIN1, TGFB2 481 21 13528 10.71419 0.019679 4.11E-05 0.009472 stress-activated protein kinase signaling pathway
GO:0018105~peptidyl-serine 5.27E-06 AKT1, BCL2, NLK, ILK, TGFBR2, PRKDC, MAP4K1, PRKACA, STK4 481 29 13528 8.728368 0.02027 4.23E-05 0.00976 phosphorylation GO:0010675~regulation of cellular 5.38E-06 AKT1, HDAC4, INS, IGF1, IGF2, MTOR, INSR, PPARGC1A, IRS1, ARNT, AKT2 481 38 13528 7.401247 0.020706 4.31E-05 0.009972 carbohydrate metabolic process
GO:0000077~DNA damage checkpoint 5.60E-06 CDK1, NBN, CCND1, BLM, MAPK14, HUS1, TP53, H2AFX, ATR, CCNA2, BRCA1 481 48 13528 6.445253 0.021538 4.48E-05 0.010377
GO:0030183~B cell differentiation 5.60E-06 HDAC4, BCL2, BAX, PLCG2, TP53, RAG1, ADAM17, PRKDC, RAG2, TSHR, ADA 481 48 13528 6.445253 0.021538 4.48E-05 0.010377
GO:0010721~negative regulation of cell 5.60E-06 BMP4, BDNF, NOG, PTK2, PSEN1, DLL3, TP53, NGFR, TGFB1, EPHB2, SPP1 481 48 13528 6.445253 0.021538 4.48E-05 0.010377 development
GO:0043388~positive regulation of DNA 5.68E-06 TNF, TLR4, TGFB1, PRKCQ, HDAC4, NOD2, EP300, MYD88, HIPK2, JAK2, BRD4, IKBKB, ERCC2 481 70 13528 5.223166 0.021824 4.53E-05 0.010516 binding
GO:0030005~cellular di-, tri-valent 6.03E-06 PTPRC, CAV1, CCKBR, DRD2, GRIN1, PTH1R, FZD2, CXCR3, TGFB1, ATP7A, EDNRB, VDR, 481 227 13528 2.973541 0.023171 4.80E-05 0.011173 inorganic cation homeostasis PSEN1, CXCR4, APOE, BAX, BCL2, MT2A, PLCG2, JAK2, EPOR, PRNP, MYC, F2R
GO:0010608~posttranscriptional 6.04E-06 GTPBP4, TNF, SMAD3, MKNK1, PRKDC, IGF2BP1, SOX4, ELAVL1, SMAD2, SMAD1, PPARGC1A, 481 211 13528 3.06573 0.023211 4.80E-05 0.011192 regulation of gene expression PTEN, PRKCD, AKT1, MAPK1, TNFRSF1B, CDKN2A, TSC1, BCL2, VEGFA, QKI, MTOR, EIF2AK3
GO:0001954~positive regulation of 6.17E-06 CD36, TSC1, CSF1, ILK, SMAD3, CDK6 481 9 13528 18.74983 0.023688 4.89E-05 0.011425 cell-matrix adhesion
GO:0048009~insulin-like growth factor 6.17E-06 AKT1, IGF1R, TSC2, EIF2AK3, IRS1, GHR 481 9 13528 18.74983 0.023688 4.89E-05 0.011425 receptor signaling pathway
GO:0033158~regulation of protein import 6.17E-06 BMP4, SMAD4, TGFB3, JAK2, SIRT1, TGFB1 481 9 13528 18.74983 0.023688 4.89E-05 0.011425 into nucleus, translocation
GO:0010717~regulation of epithelial to 6.17E-06 SMAD4, TGFB3, SMAD3, SMAD2, TGFB1, TGFB2 481 9 13528 18.74983 0.023688 4.89E-05 0.011425 mesenchymal transition
GO:0042254~ribosome biogenesis 6.33E-06 EIF6, GTPBP4, TBL3, UTP15, HEATR1, CDKN2A, WDR36, DKC1, NOLC1, TSC1, WDR3, AATF, 481 122 13528 3.919021 0.024309 5.01E-05 0.011728
POP4, UTP14A, TFB1M, IMP4, UTP14C
GO:0032386~regulation of intracellular 6.62E-06 BMP4, TNF, TGFB3, SMAD4, SMAD3, GLI3, SIRT1, TGFB1, PRKCQ, CDKN2A, PRKACA, JAK2, 481 71 13528 5.1496 0.025385 5.23E-05 0.012254 transport MBTPS1
GO:0042102~positive regulation of T cell 6.78E-06 PRKCQ, PTPRC, IL2RA, BLM, IL18, EFNB1, STAT5A, STAT5B, ZAP70, SYK 481 39 13528 7.211472 0.02601 5.35E-05 0.01256 proliferation GO:0006109~regulation of carbohydrate 6.78E-06 AKT1, HDAC4, INS, IGF1, IGF2, MTOR, INSR, PPARGC1A, IRS1, ARNT, AKT2 481 39 13528 7.211472 0.02601 5.35E-05 0.01256 metabolic process
GO:0001947~heart looping 7.27E-06 BBS4, PSEN1, GATA4, MKKS, SRF, ENG, NKX2-5, ZIC3 481 22 13528 10.22718 0.027867 5.72E-05 0.01347
GO:0032102~negative regulation of 8.25E-06 TNFRSF1B, IL2RA, INS, DRD2, APOE, SLC6A3, GRIN1, PPARG, IGF2, MTOR, ADA, SPP1 481 50 13528 6.187443 0.031577 6.48E-05 0.015292 response to external stimulus
GO:0046661~male sex differentiation 8.91E-06 AR, STAT5A, SMAD5, STAT5B, SOX9, WT1, ACVR2A, CCND1, BAX, BCL2, NKX2-1, FANCA, 481 73 13528 5.008515 0.034032 6.98E-05 0.016501
NR5A1
GO:0006302~double-strand break repair 9.89E-06 XRCC5, EYA1, NBN, BLM, VCP, HUS1, TP53, PRKDC, BRCA2, H2AFX, RAD50, BRCA1 481 62 13528 5.443498 0.037712 7.73E-05 0.01832
GO:0043269~regulation of ion transport 9.93E-06 CAV1, NOS1, TNF, LYN, DRD2, IL13, TGFB1, AKT1, BAX, BCL2, PLCG2, NOS3, NKX2-5, AKT2, 481 99 13528 4.261324 0.037877 7.75E-05 0.018402
F2R
GO:0010332~response to gamma radiation 1.01E-05 MEN1, PTPRC, CAV1, BCL2, BAX, TP53, PRKDC, BRCA2 481 23 13528 9.782518 0.038627 7.89E-05 0.018774
GO:0001541~ovarian follicle development 1.05E-05 BMP4, CCNE1, TAF4, BCL2, BAX, VEGFA, FOXC1, MMP14, BMPR1B, KDR 481 41 13528 6.859693 0.040078 8.18E-05 0.019493
GO:0002761~regulation of myeloid 1.05E-05 TNF, JUN, STAT5A, CSF1, KITLG, TLR4, RB1, INPP5D, RUNX1, APC 481 41 13528 6.859693 0.040078 8.18E-05 0.019493 leukocyte differentiation
GO:0055080~cation homeostasis 1.09E-05 CAV1, DRD2, PTH1R, CXCR3, TGFB1, VDR, EDNRB, CXCR4, APOE, BCL2, MYC, PTPRC, CCKBR, 481 286 13528 2.655133 0.041663 8.49E-05 0.020281
HTT, GRIN1, TP53, FZD2, KDR, ATP7A, PSEN1, BAX, MT2A, PLCG2, JAK2, EPOR, PRNP, F2R
GO:0050999~regulation of nitric-oxide 1.14E-05 EGFR, AKT1, ACVR2A, INS, APOE, IGF2, ENG, GCH1 481 16 13528 12.30457 0.043481 8.86E-05 0.021185 synthase activity
GO:0048863~stem cell differentiation 1.18E-05 XRCC5, NOG, PAX7, CREBBP, TCL1A, IGF1, KIT, ERCC2, APC 481 32 13528 7.910083 0.044662 9.08E-05 0.021774
GO:0060021~palate development 1.18E-05 MEN1, CHD7, MEOX2, TGFBR2, SMAD4, TGFB3, LEF1, SMAD2, COL2A1 481 32 13528 7.910083 0.044662 9.08E-05 0.021774
GO:0045582~positive regulation of T cell 1.18E-05 PTPRC, IL2RA, STAT5A, STAT5B, TGFBR2, ZAP70, RARA, ADA, SYK 481 32 13528 7.910083 0.044662 9.08E-05 0.021774 differentiation
GO:0055074~calcium ion homeostasis 1.18E-05 PTPRC, CAV1, CCKBR, DRD2, GRIN1, PTH1R, FZD2, CXCR3, TGFB1, KDR, EDNRB, VDR, PSEN1, 481 188 13528 3.141593 0.044928 9.12E-05 0.021907
CXCR4, APOE, BAX, BCL2, PLCG2, JAK2, EPOR, F2R
GO:0031570~DNA integrity checkpoint 1.19E-05 CDK1, NBN, CCND1, BLM, MAPK14, HUS1, TP53, H2AFX, ATR, CCNA2, BRCA1 481 52 13528 5.949464 0.045311 9.18E-05 0.022098
GO:0030003~cellular cation homeostasis 1.25E-05 CAV1, DRD2, PTH1R, CXCR3, TGFB1, VDR, EDNRB, APOE, CXCR4, BCL2, MYC, PTPRC, CCKBR, 481 254 13528 2.768183 0.047553 9.63E-05 0.023218 GRIN1, TP53, FZD2, ATP7A, PSEN1, BAX, MT2A, PLCG2, JAK2, EPOR, PRNP, F2R
GO:0032103~positive regulation of 1.36E-05 TNFRSF1A, PLA2G4A, STAT5A, VEGFA, STAT5B, ADAM17, SMAD3, FGF10, JAK2, TLR4, TGFB1, 481 64 13528 5.273389 0.051386 1.04E-04 0.02514 response to external stimulus KDR
GO:0031668~cellular response to 1.36E-05 VDR, CCNE1, FOS, CDKN1A, CAV1, PSEN1, LYN, JUN, LEPR, TP53, SIRT1, HDAC6 481 64 13528 5.273389 0.051386 1.04E-04 0.02514 extracellular stimulus
GO:0050851~antigen receptor-mediated 1.50E-05 MAP3K7, MAPK1, PTPRC, PSEN1, LYN, PSEN2, PLCG2, ZAP70, SYK 481 33 13528 7.670384 0.05678 1.15E-04 0.027857 signaling pathway
GO:0045665~negative regulation of 1.50E-05 HES1, HOXA2, NBN, NOTCH1, HES5, FOXA2, FOXG1, PAX6, PBX1 481 33 13528 7.670384 0.05678 1.15E-04 0.027857 neuron differentiation
GO:0009855~determination of bilateral 1.59E-05 ACVR2A, ALDH1A2, NOTCH1, NKX3-2, MKKS, FGF10, ZIC3, CITED2, PITX2, ACVR1 481 43 13528 6.540637 0.059941 1.21E-04 0.029457 symmetry
GO:0007162~negative regulation of cell 1.59E-05 GTPBP4, CDKN2A, NF2, ERBB3, JAK2, COL1A1, MMP14, PTEN, RASA1, TGFB1 481 43 13528 6.540637 0.059941 1.21E-04 0.029457 adhesion
GO:0009799~determination of symmetry 1.59E-05 ACVR2A, ALDH1A2, NOTCH1, NKX3-2, MKKS, FGF10, ZIC3, CITED2, PITX2, ACVR1 481 43 13528 6.540637 0.059941 1.21E-04 0.029457
GO:0018205~peptidyl-lysine modification 1.71E-05 ATP7A, HDAC4, EP300, CREBBP, DHPS, SIRT1, HDAC6 481 17 13528 11.58078 0.064478 1.31E-04 0.031761
GO:0007519~skeletal muscle tissue 1.84E-05 CAV1, EP300, MEOX2, ERBB3, MAPK14, PAX7, ERBB2, MYF5, SIX1, PITX1, F2R, FOXP2 481 66 13528 5.113589 0.068982 1.40E-04 0.034061 development
GO:0060538~skeletal muscle organ 1.84E-05 CAV1, EP300, MEOX2, ERBB3, MAPK14, PAX7, ERBB2, MYF5, SIX1, PITX1, F2R, FOXP2 481 66 13528 5.113589 0.068982 1.40E-04 0.034061 development
GO:0010743~regulation of foam cell 1.87E-05 NR1H2, CD36, CSF1, PPARG, MAPK9, NFKB1, ABCA1, ITGB3 481 25 13528 8.999917 0.070046 1.42E-04 0.034606 differentiation
GO:0001756~somitogenesis 1.91E-05 EP300, PSEN1, MEOX2, PSEN2, MYF5, DLL3, PRKDC, LEF1, ROR2 481 34 13528 7.444784 0.071414 1.44E-04 0.035307
GO:0016055~Wnt receptor signaling 1.92E-05 WNT5A, RARG, NLK, CSNK2B, LEF1, CTNND1, SOX4, FZD2, CTNNBIP1, CSNK2A2, HHEX, 481 133 13528 3.594892 0.072056 1.45E-04 0.035637 pathway CCND1, CSNK2A1, ROR2, TBL1X, APC, AXIN1
GO:0002244~hemopoietic progenitor cell 2.13E-05 PSEN1, BCL2, PSEN2, PRKDC, SOX4, KIT 481 11 13528 15.34077 0.07951 1.61E-04 0.03948 differentiation GO:0045736~negative regulation of 2.13E-05 MEN1, CDKN1A, CDKN1B, CDKN2A, LATS2, APC 481 11 13528 15.34077 0.07951 1.61E-04 0.03948 cyclin-dependent protein kinase activity
GO:0010812~negative regulation of 2.13E-05 CDKN2A, NF2, COL1A1, MMP14, PTEN, RASA1 481 11 13528 15.34077 0.07951 1.61E-04 0.03948 cell-substrate adhesion
GO:0043586~tongue development 2.13E-05 EGFR, BMP4, HOXC13, ERBB3, ERBB2, NKX2-5 481 11 13528 15.34077 0.07951 1.61E-04 0.03948
GO:0046890~regulation of lipid 2.35E-05 NR1H2, AKT1, PLA2G4A, TNF, INS, APOE, NFKB1, IGF2, GFI1, BRCA1, NR5A1 481 45 13528 6.249942 0.087163 1.77E-04 0.043457 biosynthetic process
GO:0048145~regulation of fibroblast 2.39E-05 CDKN1A, NBN, BAX, SPHK1, TP53, IGF1, CDK6, NGFR, CCNA2 481 35 13528 7.232076 0.088891 1.80E-04 0.04436 proliferation
GO:0022037~metencephalon development 2.39E-05 ATP7A, HOXA1, HOXB1, BCL2, GRIN1, GBX2, NEUROD1, GLI2, FOXP2 481 35 13528 7.232076 0.088891 1.80E-04 0.04436
GO:0031100~organ regeneration 2.48E-05 CCNE1, CDKN1A, CCND1, SOCS1, PPARG, LRP2, CCNA2, TGFB1 481 26 13528 8.653766 0.091862 1.86E-04 0.045915
GO:0051353~positive regulation of 2.48E-05 ATP7A, AKT1, VDR, TNF, INS, APOE, IGF2, ABL1, GCH1 481 26 13528 8.653766 0.091862 1.86E-04 0.045915 oxidoreductase activity
GO:0030330~DNA damage response, 2.48E-05 NBN, MYO6, HIPK1, HIPK2, TP53, TP63, BRCA2, BRCA1 481 26 13528 8.653766 0.091862 1.86E-04 0.045915 signal transduction by p53 class mediator
GO:0001837~epithelial to mesenchymal 2.50E-05 NOG, NOTCH1, BMP2, LEF1, SOX9, TGFB1, TGFB2 481 18 13528 10.9374 0.092437 1.87E-04 0.046217 transition
GO:0018107~peptidyl-threonine 2.50E-05 ACVR1B, PDPK1, BCL2, NLK, TGFBR2, MAPK8, MTOR 481 18 13528 10.9374 0.092437 1.87E-04 0.046217 phosphorylation
GO:0010464~regulation of mesenchymal 2.50E-05 VEGFA, TGFBR2, TP63, ZEB1, IRS1, KDR, FOXP2 481 18 13528 10.9374 0.092437 1.87E-04 0.046217 cell proliferation
GO:0010959~regulation of metal ion 2.65E-05 CAV1, NOS1, LYN, DRD2, TGFB1, AKT1, BAX, BCL2, PLCG2, NOS3, NKX2-5, AKT2, F2R 481 81 13528 4.513847 0.097862 1.98E-04 0.049074 transport
GO:0006874~cellular calcium ion 2.75E-05 PTPRC, CAV1, CCKBR, DRD2, GRIN1, PTH1R, FZD2, CXCR3, TGFB1, EDNRB, VDR, PSEN1, 481 183 13528 3.073742 0.101276 2.05E-04 0.05088 homeostasis CXCR4, APOE, BAX, BCL2, PLCG2, JAK2, EPOR, F2R
GO:0001816~cytokine production 2.83E-05 NOD2, MYD88, LYN, REL, IL18, TLR4, ABCA1, NFATC2, PRKCD, LCP2 481 46 13528 6.114074 0.104043 2.10E-04 0.052349 GO:0048660~regulation of smooth muscle 2.83E-05 EGFR, TNF, JUN, ILK, VEGFA, STAT5B, TGFBR2, IGF1, NOS3, STAT1 481 46 13528 6.114074 0.104043 2.10E-04 0.052349 cell proliferation
GO:0031331~positive regulation of 2.98E-05 AKT1, TNF, INS, APOE, IGF1, IGF2, INSR, IRS1, ARNT, AKT2 481 36 13528 7.031185 0.109537 2.22E-04 0.055278 cellular catabolic process
GO:0048168~regulation of neuronal 2.98E-05 EGR1, HRAS, EGR2, DRD2, APOE, SNCA, GRIN1, KIT, EPHB2 481 36 13528 7.031185 0.109537 2.22E-04 0.055278 synaptic plasticity
GO:0030518~steroid hormone receptor 3.25E-05 CCNE1, AR, ESR1, RARA, JAK2, RB1, ESR2, PPARGC1A, DAXX, BRCA1, MED1 481 58 13528 5.334002 0.118734 2.41E-04 0.060224 signaling pathway
GO:0050708~regulation of protein 3.25E-05 PRKCQ, NOD2, ACHE, TNF, INS, DRD2, TGFB3, IL13, IGF2, FOXP3, TGFB1, TGFB2 481 58 13528 5.334002 0.118734 2.41E-04 0.060224 secretion
GO:0019221~cytokine-mediated signaling 3.26E-05 STAT6, TNFRSF1A, STAT4, TNF, STAT5A, LEPR, SOCS1, STAT5B, JAK1, KIT, STAT1, STAT3 481 70 13528 4.821384 0.119017 2.41E-04 0.060377 pathway
GO:0050731~positive regulation of 3.39E-05 NOD2, LYN, INS, IGF1, KITLG, IGF2, JAK2, TLR4, MTOR, GHR, SYK 481 47 13528 5.983987 0.123369 2.50E-04 0.062736 peptidyl-tyrosine phosphorylation
GO:0002683~negative regulation of 3.40E-05 PTPRC, IL2RA, ERBB2, IGF2, FOXP3, TGFB1, ADA, TGFB2, STAT6, NOD2, CDKN2A, INS, INPP5D, 481 83 13528 4.40508 0.123887 2.51E-04 0.063017 immune system process FAS
GO:0009266~response to temperature 3.40E-05 NOS1, LYN, IL18, PPARG, AKT1, PRKCQ, FOS, PLA2G4A, HSF1, BCL2, HSPB2, NOS3, NGFR 481 83 13528 4.40508 0.123887 2.51E-04 0.063017 stimulus
GO:0048536~spleen development 3.54E-05 BCL2, NKX3-2, ADAM17, FGF10, PBX1, FAS, NKX2-5 481 19 13528 10.36175 0.128491 2.60E-04 0.065527
GO:0008354~germ cell migration 3.55E-05 CXCR4, BAX, PRKDC, FOXC1, KIT, TGFB1 481 12 13528 14.06237 0.128807 2.61E-04 0.0657
GO:0014068~positive regulation of 3.55E-05 ERBB3, INS, ERBB2, IGF1, IGF2, JAK2, TGFB2 481 12 13528 14.06237 0.128807 2.61E-04 0.0657 phosphoinositide 3-kinase cascade
GO:0045885~positive regulation of 3.55E-05 MEF2C, STAT5A, STAT5B, ESR1, ESR2, NKX2-5 481 12 13528 14.06237 0.128807 2.61E-04 0.0657 survival gene product expression
GO:0035050~embryonic heart tube 3.55E-05 HHEX, GATA4, FOXC2, FOXC1, NKX2-5, MED1 481 12 13528 14.06237 0.128807 2.61E-04 0.0657 development GO:0048566~embryonic gut development 3.55E-05 ALDH1A2, GATA4, FGF10, GLI2, GLI3, ADA 481 12 13528 14.06237 0.128807 2.61E-04 0.0657
GO:0045793~positive regulation of cell 4.04E-05 AKT1, EP300, INS, ILK, SPHK1, ADAM17, IGF2, SFN, NRG1, TP73, TGFB2 481 48 13528 5.859321 0.145322 2.96E-04 0.074815 size
GO:0051346~negative regulation of 4.04E-05 CDKN2D, LEPR, SNCA, TP53, RAG1, NOS3, BIRC5, SFN, SIRT1, TGFB2 481 48 13528 5.859321 0.145322 2.96E-04 0.074815 hydrolase activity
GO:0055065~metal ion homeostasis 4.19E-05 PTPRC, CAV1, CCKBR, DRD2, GRIN1, PTH1R, FZD2, CXCR3, TGFB1, KDR, EDNRB, VDR, PSEN1, 481 205 13528 2.881071 0.150151 3.06E-04 0.077514
CXCR4, APOE, BAX, BCL2, PLCG2, JAK2, EPOR, F2R
GO:0046320~regulation of fatty acid 4.20E-05 AKT1, STK11, PPARG, PRKAB1, MTOR, PPARGC1A, IRS1, AKT2 481 28 13528 8.03564 0.15048 3.07E-04 0.077698 oxidation
GO:0009896~positive regulation of 4.80E-05 AKT1, TNF, INS, APOE, IGF1, IGF2, INSR, IRS1, ARNT, APC, AKT2 481 49 13528 5.739743 0.170059 3.50E-04 0.088802 catabolic process
GO:0051385~response to 4.90E-05 CCNE1, FOS, CDKN1A, CCND1, BCL2, PTGS1, SRC 481 20 13528 9.843659 0.173549 3.57E-04 0.090809 mineralocorticoid stimulus
GO:0042417~dopamine metabolic process 4.90E-05 ATP7A, DRD2, SLC6A3, SNCA, PARK2, GCH1, TGFB2 481 20 13528 9.843659 0.173549 3.57E-04 0.090809
GO:0033160~positive regulation of 5.03E-05 BMP4, SMAD4, TGFB3, JAK2, TGFB1 481 7 13528 20.0891 0.177636 3.65E-04 0.093169 protein import into nucleus, translocation
GO:0007435~salivary gland 5.03E-05 EGFR, PAX6, TGFB3, TGFB1, TGFB2 481 7 13528 20.0891 0.177636 3.65E-04 0.093169 morphogenesis
GO:0031329~regulation of cellular 5.11E-05 AKT1, HDAC4, TNF, INS, APOE, IGF1, IGF2, MTOR, INSR, IRS1, ARNT, AKT2 481 61 13528 5.071674 0.180125 3.70E-04 0.094612 catabolic process
GO:0043588~skin development 5.36E-05 ATP7A, LEF1, TP63, SFN, NGFR, COL1A1, ERCC2, APC 481 29 13528 7.758549 0.188166 3.88E-04 0.099305
GO:0051276~chromosome organization 5.48E-05 XRCC5, NBN, BLM, PRKDC, MEN1, NIPBL, CHD7, DKC1, H2AFX, MLL4, CDCA5, TOP2A, HELLS, 481 485 13528 2.08761 0.191903 3.96E-04 0.101503
TERT, APC, SETDB1, PDS5B, MLL, RBL2, TAF5, RBL1, CREBBP, TP53, BRCA2, RB1, MCM2,
FOXP3, SIRT1, RAD50, HDAC4, EYA1, KDM2B, EP300, ATXN7, DNMT1, HDAC6
GO:0051781~positive regulation of cell 5.53E-05 MEN1, INS, VEGFA, TGFB3, TGFA, IGF2, FGF2, TGFB1, TGFB2, APC 481 39 13528 6.490325 0.193305 3.98E-04 0.102329 division GO:0051147~regulation of muscle cell 5.53E-05 BMP4, HDAC4, NOTCH1, BCL2, ILK, ZEB1, NRG1, SRF, NKX2-5 481 39 13528 6.490325 0.193305 3.98E-04 0.102329 differentiation
GO:0002429~immune response-activating 5.53E-05 MAP3K7, MAPK1, PTPRC, PSEN1, LYN, PSEN2, PLCG2, ZAP70, SYK 481 39 13528 6.490325 0.193305 3.98E-04 0.102329 cell surface receptor signaling pathway
GO:0051053~negative regulation of DNA 5.53E-05 GTPBP4, BLM, NF2, HUS1, TGFB3, TP53, BRCA2, ATR, TGFB1 481 39 13528 6.490325 0.193305 3.98E-04 0.102329 metabolic process
GO:0018209~peptidyl-serine modification 5.53E-05 AKT1, BCL2, NLK, ILK, TGFBR2, PRKDC, MAP4K1, PRKACA, STK4 481 39 13528 6.490325 0.193305 3.98E-04 0.102329
GO:0048820~hair follicle maturation 5.60E-05 AKT1, NOTCH1, PSEN1, PSEN2, ERCC2, TGFB2 481 13 13528 12.98065 0.195517 4.03E-04 0.103636
GO:0051354~negative regulation of 5.60E-05 INS, SNCA, NFKB1, IGF2, GFI1, ENG, HDAC6 481 13 13528 12.98065 0.195517 4.03E-04 0.103636 oxidoreductase activity
GO:0008045~motor axon guidance 5.60E-05 HOXA1, HOXA2, EGR2, CXCR4, ERBB2, ETV4 481 13 13528 12.98065 0.195517 4.03E-04 0.103636
GO:0031056~regulation of histone 5.60E-05 MEN1, MLL, SNCA, DNMT1, FOXP3, PPARGC1A 481 13 13528 12.98065 0.195517 4.03E-04 0.103636 modification
GO:0000302~response to reactive oxygen 6.29E-05 ATP7A, FOS, PLA2G4A, EP300, ERBB4, APOE, JUN, BCL2, COL1A1, STAT1, ADA, HDAC6 481 75 13528 4.499958 0.216924 4.52E-04 0.116477 species
GO:0048546~digestive tract 6.66E-05 NOTCH1, BCL2, GATA4, TP63, GLI2, GLI3, TP73 481 21 13528 9.374913 0.22811 4.78E-04 0.123326 morphogenesis
GO:0018210~peptidyl-threonine 6.66E-05 ACVR1B, PDPK1, BCL2, NLK, TGFBR2, MAPK8, MTOR 481 21 13528 9.374913 0.22811 4.78E-04 0.123326 modification
GO:0043255~regulation of carbohydrate 6.66E-05 AKT1, INS, IGF2, MTOR, INSR, PPARGC1A, IRS1, AKT2 481 21 13528 9.374913 0.22811 4.78E-04 0.123326 biosynthetic process
GO:0055123~digestive system 6.66E-05 NOTCH1, BCL2, GATA4, TP63, GLI2, GLI3, TP73 481 21 13528 9.374913 0.22811 4.78E-04 0.123326 development
GO:0014013~regulation of gliogenesis 6.66E-05 BMP4, NOG, NOTCH1, BMP2, LYN, PPARG, DLL3 481 21 13528 9.374913 0.22811 4.78E-04 0.123326
GO:0001569~patterning of blood vessels 6.66E-05 CXCR4, VEGFA, TGFBR2, GBX2, FOXC2, ENG, ACVR1 481 21 13528 9.374913 0.22811 4.78E-04 0.123326
GO:0048169~regulation of long-term 6.66E-05 EGR1, HRAS, DRD2, SNCA, GRIN1, KIT, EPHB2 481 21 13528 9.374913 0.22811 4.78E-04 0.123326 neuronal synaptic plasticity
GO:0043392~negative regulation of DNA 6.67E-05 MEN1, PTHLH, HDAC4, NOD2, CDKN2A, ID1, PBX1, JAK2, FOXP3, SIRT1 481 51 13528 5.514655 0.228326 4.77E-04 0.123459 binding
GO:0010243~response to organic nitrogen 6.80E-05 CCNE1, CDKN1A, PLA2G4A, CCND1, LYN, DRD2, PTGS1, GRIN1, NOS3, SMAD1, MTOR 481 63 13528 4.910669 0.232164 4.86E-04 0.125832
GO:0006875~cellular metal ion 7.07E-05 PTPRC, CAV1, CCKBR, DRD2, GRIN1, PTH1R, FZD2, CXCR3, TGFB1, EDNRB, VDR, PSEN1, 481 196 13528 2.869871 0.240226 5.04E-04 0.130856 homeostasis CXCR4, APOE, BAX, BCL2, PLCG2, JAK2, EPOR, F2R
GO:0050727~regulation of inflammatory 7.12E-05 IL2RA, STAT5A, PPARG, STAT5B, TLR4, IGF2, ADA, TNFRSF1A, TNFRSF1B, PLA2G4A, APOE, 481 76 13528 4.440748 0.241892 5.07E-04 0.131902 response INS, JAK2
GO:0001819~positive regulation of 7.69E-05 TNF, IL18, SMAD3, TLR4, TGFB1, ARNT, MAP3K7, NOD2, MYD88, GATA4, ADAM17, JAK2, 481 90 13528 4.062462 0.258295 5.46E-04 0.142313 cytokine production RARA
GO:0006281~DNA repair 7.69E-05 XRCC5, NBN, BLM, HUS1, PRKDC, MEN1, CDKN2D, H2AFX, APEX1, TOP2A, FANCA, ERCC2, 481 284 13528 2.475769 0.258455 5.46E-04 0.142416
SSRP1, POLG, TP53, BRCA2, MBD4, ATR, SIRT1, TP73, BRCA1, RAD50, EYA1, VCP, ABL1
GO:0030198~extracellular matrix 7.72E-05 ELF3, LGALS3, MMP9, MYF5, COL2A1, TGFB2, ATP7A, PTK2, ILK, FOXC2, FOXC1, COL1A1, 481 104 13528 3.786023 0.259158 5.46E-04 0.142867 organization ENG, ERCC2
GO:0006997~nucleus organization 7.81E-05 SYNE1, CDKN2A, ETS1, ATXN7, BAX, LMNA, PAFAH1B1, APAF1, TOP2A, MYC 481 52 13528 5.408604 0.261946 5.52E-04 0.144662
GO:0008584~male gonad development 7.81E-05 ACVR2A, CCND1, AR, BCL2, BAX, NKX2-1, SOX9, FANCA, WT1, NR5A1 481 52 13528 5.408604 0.261946 5.52E-04 0.144662
GO:0040029~regulation of gene 8.05E-05 MLL, SMAD3, SMAD2, IGF2, SIRT6, SMAD1, SIRT1, BRCA1, FOS, INS, DNMT1, MLL4, HELLS 481 77 13528 4.383076 0.268709 5.68E-04 0.149043 expression, epigenetic
GO:0050818~regulation of coagulation 8.06E-05 SELP, CAV1, PSEN1, APOE, PSEN2, NOS3, TLR4, PLAU, F2R 481 41 13528 6.173723 0.269086 5.68E-04 0.149288
GO:0050714~positive regulation of 8.06E-05 PRKCQ, NOD2, ACHE, TNF, INS, TGFB3, IL13, IGF2, TGFB1, TGFB2 481 41 13528 6.173723 0.269086 5.68E-04 0.149288 protein secretion
GO:0010862~positive regulation of 8.45E-05 BMP4, BMP2, SMAD4, TGFB3, ENG, TGFB1 481 14 13528 12.05346 0.280056 5.94E-04 0.156485 pathway-restricted SMAD protein phosphorylation
GO:0032885~regulation of polysaccharide 8.45E-05 AKT1, INS, IGF2, MTOR, INSR, IRS1, AKT2 481 14 13528 12.05346 0.280056 5.94E-04 0.156485 biosynthetic process GO:0005979~regulation of glycogen 8.45E-05 AKT1, INS, IGF2, MTOR, INSR, IRS1, AKT2 481 14 13528 12.05346 0.280056 5.94E-04 0.156485 biosynthetic process
GO:0035265~organ growth 8.45E-05 BCL2, RXRA, FOXC2, SMAD2, FOXC1, TGFB2 481 14 13528 12.05346 0.280056 5.94E-04 0.156485
GO:0010962~regulation of glucan 8.45E-05 AKT1, INS, IGF2, MTOR, INSR, IRS1, AKT2 481 14 13528 12.05346 0.280056 5.94E-04 0.156485 biosynthetic process
GO:0048661~positive regulation of 8.50E-05 EGFR, TNF, JUN, VEGFA, STAT5B, TGFBR2, IGF1, STAT1 481 31 13528 7.257997 0.281264 5.96E-04 0.157284 smooth muscle cell proliferation
GO:0046326~positive regulation of 8.89E-05 AKT1, ERBB4, ERBB3, INS, IGF2, INSR, IRS1, AKT2 481 22 13528 8.948781 0.292071 6.22E-04 0.164492 glucose import
GO:0045682~regulation of epidermis 8.89E-05 NOTCH1, TNF, FST, TP63, NGFR, AQP3, TGFB2 481 22 13528 8.948781 0.292071 6.22E-04 0.164492 development
GO:0022407~regulation of cell-cell 8.89E-05 GTPBP4, TNF, NF2, JAK2, ADA, TGFB1, CITED2 481 22 13528 8.948781 0.292071 6.22E-04 0.164492 adhesion
GO:0021766~hippocampus development 8.89E-05 BBS4, TSC1, NKX2-1, LEF1, MKKS, PAFAH1B1, TP73 481 22 13528 8.948781 0.292071 6.22E-04 0.164492
GO:0045930~negative regulation of 8.89E-05 EGFR, BCL2, SMAD3, FOXC1, RB1, TGFB1, DLG1 481 22 13528 8.948781 0.292071 6.22E-04 0.164492 mitotic cell cycle
GO:0048538~thymus development 8.89E-05 CRKL, PSEN1, BCL2, PSEN2, SIX1, PBX1, APC 481 22 13528 8.948781 0.292071 6.22E-04 0.164492
GO:0010828~positive regulation of 8.89E-05 AKT1, ERBB4, ERBB3, INS, IGF2, INSR, IRS1, AKT2 481 22 13528 8.948781 0.292071 6.22E-04 0.164492 glucose transport
GO:0045444~fat cell differentiation 9.12E-05 BBS4, CCND1, CEBPB, SOCS1, PPARG, MKKS, INSR, PPARGC1A, SIRT1, MED1 481 53 13528 5.306555 0.298507 6.37E-04 0.168838
GO:0006364~rRNA processing 9.55E-05 TBL3, UTP15, HEATR1, WDR36, CDKN2A, NOLC1, DKC1, WDR3, POP4, UTP14A, TFB1M, IMP4, 481 92 13528 3.974148 0.310125 6.66E-04 0.176785
UTP14C
GO:0007368~determination of left/right 9.66E-05 ACVR2A, NOTCH1, NKX3-2, MKKS, FGF10, ZIC3, CITED2, PITX2, ACVR1 481 42 13528 6.02673 0.31295 6.72E-04 0.178737 symmetry
GO:0002768~immune response-regulating 9.66E-05 MAP3K7, MAPK1, PTPRC, PSEN1, LYN, PSEN2, PLCG2, ZAP70, SYK 481 42 13528 6.02673 0.31295 6.72E-04 0.178737 cell surface receptor signaling pathway GO:0030307~positive regulation of cell 9.66E-05 AKT1, EP300, INS, ILK, SPHK1, ADAM17, IGF2, SFN, NRG1, TGFB2 481 42 13528 6.02673 0.31295 6.72E-04 0.178737 growth
GO:0051893~regulation of focal adhesion 9.78E-05 TSC1, TSC2, SMAD3, MMP14, PTEN 481 8 13528 17.57796 0.31626 6.80E-04 0.181034 formation
GO:0007183~SMAD protein complex 9.78E-05 SMAD4, SMAD3, SMAD2, SMAD1, TGFB1 481 8 13528 17.57796 0.31626 6.80E-04 0.181034 assembly
GO:0033032~regulation of myeloid cell 9.78E-05 MAEA, CD44, BCL2, STAT5A, ADAM17 481 8 13528 17.57796 0.31626 6.80E-04 0.181034 apoptosis
GO:0060396~growth hormone receptor 9.78E-05 STAT5A, STAT5B, JAK2, STAT3, GHR 481 8 13528 17.57796 0.31626 6.80E-04 0.181034 signaling pathway
GO:0007184~SMAD protein nuclear 9.78E-05 JUN, TGFB3, SPTBN1, TGFB1, TGFB2 481 8 13528 17.57796 0.31626 6.80E-04 0.181034 translocation
GO:0043122~regulation of I-kappaB 1.04E-04 TNF, FASLG, FADD, TLR4, MAP3K7, IKBKE, TNFRSF1A, NOD2, MYD88, REL, CASP8, TNFAIP3, 481 107 13528 3.679873 0.331885 7.20E-04 0.192032 kinase/NF-kappaB cascade IKBKB, F2R
GO:0051789~response to protein stimulus 1.04E-04 EGR1, LYN, CSNK2B, TGFB1, FOS, CCND1, VCP, ID1, BCL2, HSPB2, FAS, INSR, EIF2AK3, HDAC6 481 107 13528 3.679873 0.331885 7.20E-04 0.192032
GO:0021761~limbic system development 1.05E-04 BBS4, TSC1, BAX, NKX2-1, LEF1, MKKS, PAFAH1B1, TP73 481 32 13528 7.031185 0.336313 7.30E-04 0.195195
GO:0008015~blood circulation 1.11E-04 CAV1, DRD2, PPARG, SMAD5, PTGS1, STAT1, GCH1, EDNRB, FLI1, CHD7, MEOX2, APOE, 481 186 13528 2.872957 0.351406 7.70E-04 0.206137
VEGFA, PSEN2, NKX2-1, FOXC2, NOS3, FOXC1, ENG
GO:0003013~circulatory system process 1.11E-04 CAV1, DRD2, PPARG, SMAD5, PTGS1, STAT1, GCH1, EDNRB, FLI1, CHD7, MEOX2, APOE, 481 186 13528 2.872957 0.351406 7.70E-04 0.206137
VEGFA, PSEN2, NKX2-1, FOXC2, NOS3, FOXC1, ENG
GO:0007093~mitotic cell cycle checkpoint 1.15E-04 CDK1, NBN, CCND1, HUS1, TP53, CCNA2, TGFB1, APC, DLG1 481 43 13528 5.886574 0.360467 7.94E-04 0.212828
GO:0001838~embryonic epithelial tube 1.15E-04 MAP3K7, BBS4, RET, TSC1, TSC2, CASP8, TFAP2A, APAF1, PAX3 481 43 13528 5.886574 0.360467 7.94E-04 0.212828 formation
GO:0050852~T cell receptor signaling 1.17E-04 MAP3K7, MAPK1, PTPRC, PSEN1, PSEN2, PLCG2, ZAP70 481 23 13528 8.559704 0.364551 8.04E-04 0.215875 pathway
GO:0001755~neural crest cell migration 1.17E-04 EDNRB, RET, EFNB1, GBX2, KITLG, PAX3, ACVR1 481 23 13528 8.559704 0.364551 8.04E-04 0.215875 GO:0001974~blood vessel remodeling 1.17E-04 ATP7A, BAX, VEGFA, FOXC2, FGF10, NOS3, FOXC1 481 23 13528 8.559704 0.364551 8.04E-04 0.215875
GO:0032881~regulation of polysaccharide 1.23E-04 AKT1, INS, IGF2, MTOR, INSR, IRS1, AKT2 481 15 13528 11.2499 0.380326 8.47E-04 0.22783 metabolic process
GO:0010165~response to X-ray 1.23E-04 CCND1, THBD, BLM, TP53, BRCA2, LRP2 481 15 13528 11.2499 0.380326 8.47E-04 0.22783
GO:0051047~positive regulation of 1.26E-04 ACHE, TNF, DRD2, SNCA, TGFB3, IL13, IGF2, TGFB1, TGFB2, PRKCQ, NOD2, INS, JAK2, SNAP25, 481 109 13528 3.612352 0.386228 8.62E-04 0.232381 secretion SYK
GO:0032526~response to retinoic acid 1.30E-04 BMP4, BMP2, RARG, CDKN2D, RXRA, RARA, LRP2, AQP3 481 33 13528 6.818119 0.396242 8.90E-04 0.240202
GO:0021987~cerebral cortex development 1.30E-04 BBS4, PSEN1, TSC1, BAX, GRIN1, NKX2-1, MKKS, PAFAH1B1 481 33 13528 6.818119 0.396242 8.90E-04 0.240202
GO:0046324~regulation of glucose import 1.30E-04 AKT1, TNF, ERBB4, ERBB3, INS, IGF2, INSR, IRS1, AKT2 481 33 13528 6.818119 0.396242 8.90E-04 0.240202
GO:0070661~leukocyte proliferation 1.36E-04 PTPRC, CXCR4, BCL2, BAX, TP53, RAG2, PRKCD, HELLS, TGFB1 481 44 13528 5.752788 0.411175 9.32E-04 0.25211
GO:0035148~tube lumen formation 1.36E-04 MAP3K7, BBS4, RET, TSC1, TSC2, CASP8, TFAP2A, APAF1, PAX3 481 44 13528 5.752788 0.411175 9.32E-04 0.25211
GO:0031669~cellular response to nutrient 1.36E-04 VDR, CCNE1, CAV1, PSEN1, JUN, LEPR, TP53, SIRT1, HDAC6 481 44 13528 5.752788 0.411175 9.32E-04 0.25211 levels
GO:0032943~mononuclear cell 1.36E-04 PTPRC, CXCR4, BCL2, BAX, TP53, RAG2, PRKCD, HELLS, TGFB1 481 44 13528 5.752788 0.411175 9.32E-04 0.25211 proliferation
GO:0000187~activation of MAPK activity 1.44E-04 PTPRC, TNF, CXCR4, MET, TGFB3, TGFA, MAP4K1, INSR, FGF2, DAXX, GHR, SYK 481 82 13528 4.115816 0.428353 9.82E-04 0.266184
GO:0016072~rRNA metabolic process 1.45E-04 TBL3, UTP15, HEATR1, WDR36, CDKN2A, NOLC1, DKC1, WDR3, POP4, UTP14A, TFB1M, IMP4, 481 96 13528 3.808559 0.430109 9.86E-04 0.267646
UTP14C
GO:0009894~regulation of catabolic 1.45E-04 XPO1, TNF, IGF1, IGF2, IRS1, ARNT, AKT1, HDAC4, APOE, INS, MTOR, INSR, APC, AKT2 481 96 13528 3.808559 0.430109 9.86E-04 0.267646 process
GO:0051924~regulation of calcium ion 1.50E-04 CAV1, NOS1, LYN, DRD2, BCL2, BAX, PLCG2, NOS3, NKX2-5, TGFB1, F2R 481 69 13528 4.483654 0.440789 0.001017 0.276639 transport
GO:0051129~negative regulation of 1.56E-04 SNCA, FOXP3, MMP14, PTEN, TGFB1, BRCA1, EPHB2, NR1H2, PTK2, PSEN1, DNMT1, SPTBN1, 481 142 13528 3.168985 0.455279 0.001061 0.289116 cellular component organization NGFR, APC, SPP1, HDAC6
GO:0010827~regulation of glucose 1.59E-04 AKT1, TNF, ERBB4, ERBB3, INS, IGF2, INSR, IRS1, AKT2 481 34 13528 6.617586 0.460007 0.001075 0.293259 transport GO:0043433~negative regulation of 1.61E-04 MEN1, PTHLH, HDAC4, NOD2, CDKN2A, ID1, PBX1, FOXP3, SIRT1 481 45 13528 5.624948 0.464433 0.001087 0.29717 transcription factor activity
GO:0034330~cell junction organization 1.63E-04 PDPK1, NF2, BCL2, TGFB3, SMAD3, ITGB3, TGFB1, VCL, TGFB2, APC 481 57 13528 4.934165 0.469947 0.001103 0.302087
GO:0034405~response to fluid shear stress 1.71E-04 AKT1, TGFB3, NOS3, TGFB1, CITED2 481 9 13528 15.62486 0.485811 0.001154 0.316525
GO:0050732~negative regulation of 1.71E-04 PTPRC, CAV1, NF2, SOCS1, PRKCD 481 9 13528 15.62486 0.485811 0.001154 0.316525 peptidyl-tyrosine phosphorylation
GO:0035162~embryonic hemopoiesis 1.71E-04 MLL, VEGFA, TGFBR2, PBX1, MED1 481 9 13528 15.62486 0.485811 0.001154 0.316525
GO:0017145~stem cell division 1.71E-04 NOTCH1, CDKN2A, PAFAH1B1, KIT, TGFB2 481 9 13528 15.62486 0.485811 0.001154 0.316525
GO:0060416~response to growth hormone 1.71E-04 STAT5A, STAT5B, JAK2, STAT3, GHR 481 9 13528 15.62486 0.485811 0.001154 0.316525 stimulus
GO:0021571~rhombomere 5 development 1.73E-04 HOXA1, HOXB1, EGR2, MAFB 481 4 13528 28.12474 0.489393 0.001164 0.319847
GO:0002051~osteoblast fate commitment 1.73E-04 MEN1, SMAD5, SMAD1, RUNX2 481 4 13528 28.12474 0.489393 0.001164 0.319847
GO:0060397~JAK-STAT cascade 1.73E-04 STAT5A, STAT5B, JAK2, STAT3 481 4 13528 28.12474 0.489393 0.001164 0.319847 involved in growth hormone signaling pathway
GO:0051412~response to corticosterone 1.74E-04 CCNE1, FOS, CDKN1A, CCND1, BCL2, PTGS1 481 16 13528 10.54678 0.491302 0.001169 0.321626 stimulus
GO:0060350~endochondral bone 1.74E-04 PTHLH, COL2A1, COL1A1, SOX9, RUNX2, GHR 481 16 13528 10.54678 0.491302 0.001169 0.321626 morphogenesis
GO:0050777~negative regulation of 1.93E-04 STAT6, PTPRC, INS, IGF2, INPP5D, FOXP3, TGFB1, TGFB2 481 25 13528 7.874927 0.527124 0.001293 0.356311 immune response
GO:0050778~positive regulation of 1.97E-04 PTPRC, LYN, STAT5A, STAT5B, TLR4, ADA, TGFB2, MAP3K7, MAPK1, NOD2, MYD88, PSEN1, 481 145 13528 3.10342 0.535515 0.001321 0.364814 immune response PLCG2, PSEN2, ZAP70, SYK
GO:0043473~pigmentation 2.14E-04 ATP7A, BBS4, EDNRB, DRD2, BCL2, MKKS, KIT, PAX3, MYC, OCA2 481 59 13528 4.766905 0.565127 0.001432 0.396091
GO:0048638~regulation of developmental 2.20E-04 NOG, APOE, ILK, GATA4, TGFBR2, NRG1, INSR, FGF2, SPP1 481 47 13528 5.385589 0.575176 0.00147 0.40719 growth GO:0031346~positive regulation of cell 2.20E-04 BBS4, PRKCQ, ILK, TGFB3, SMAD1, MTOR, KIT, NGFR, APC 481 47 13528 5.385589 0.575176 0.00147 0.40719 projection organization
GO:0046425~regulation of JAK-STAT 2.31E-04 CAV1, NF2, LYN, SOCS1, IGF1, JAK2, F2R, GHR 481 36 13528 6.249942 0.593148 0.001541 0.427705 cascade
GO:0002366~leukocyte activation during 2.31E-04 ATP7A, PSEN1, LYN, PSEN2, PLCG2, TP53, TLR4, ADA 481 36 13528 6.249942 0.593148 0.001541 0.427705 immune response
GO:0002263~cell activation during 2.31E-04 ATP7A, PSEN1, LYN, PSEN2, PLCG2, TP53, TLR4, ADA 481 36 13528 6.249942 0.593148 0.001541 0.427705 immune response
GO:0006605~protein targeting 2.39E-04 BID, XPO1, TNF, MYO6, HTT, TP53, TGFB3, FGF10, GLI3, TGFB1, TGFB2, AKT1, MAPK1, NUP214, 481 215 13528 2.616255 0.605226 0.00159 0.442006
JUN, TSC2, SPTBN1, JAK2, FGF2, F2R
GO:0046330~positive regulation of JNK 2.39E-04 MAP3K7, NOD2, TNF, HIPK2, TLR4, AXIN1 481 17 13528 9.926379 0.60536 0.001588 0.442168 cascade
GO:0060070~Wnt receptor signaling 2.39E-04 CCND1, RARG, SOX4, TBL1X, AXIN1, APC 481 17 13528 9.926379 0.60536 0.001588 0.442168 pathway through beta-catenin
GO:0031575~G1/S transition checkpoint 2.39E-04 NBN, CCND1, HUS1, TP53, TGFB1, DLG1 481 17 13528 9.926379 0.60536 0.001588 0.442168
GO:0002053~positive regulation of 2.39E-04 VEGFA, TGFBR2, TP63, IRS1, KDR, FOXP2 481 17 13528 9.926379 0.60536 0.001588 0.442168 mesenchymal cell proliferation
GO:0060393~regulation of 2.39E-04 BMP4, BMP2, SMAD4, TGFB3, ENG, TGFB1 481 17 13528 9.926379 0.60536 0.001588 0.442168 pathway-restricted SMAD protein phosphorylation
GO:0046635~positive regulation of 2.43E-04 PTPRC, BLM, TGFBR2, ZAP70, RARA, ADA, SYK 481 26 13528 7.572045 0.611208 0.001611 0.449251 alpha-beta T cell activation
GO:0051091~positive regulation of 2.44E-04 HDAC4, PRKCQ, NOD2, TNF, EP300, MYD88, JAK2, TLR4, IKBKB, TGFB1 481 60 13528 4.687457 0.613032 0.001616 0.451482 transcription factor activity
GO:0007612~learning 2.44E-04 FOS, HRAS, HTT, DRD2, JUN, GRIN1, KIT, PARK2, EPHB2, FOXP2 481 60 13528 4.687457 0.613032 0.001616 0.451482
GO:0042035~regulation of cytokine 2.70E-04 PRKCQ, CEBPB, TNF, REL, STAT5A, STAT5B, IGF2BP1, TLR4, INPP5D, FOXP3, SYK 481 74 13528 4.180705 0.649526 0.001782 0.498469 biosynthetic process
GO:0051146~striated muscle cell 2.72E-04 HRAS, NOS1, TSC1, ERBB2, RXRA, IGF1, RB1, RARB, NRG1, CAPN2, NKX2-5, F2R 481 88 13528 3.835192 0.652197 0.001791 0.502097 differentiation
GO:0008286~insulin receptor signaling 2.77E-04 AKT1, IGF1R, GRB2, INS, FOXC2, IGF2, INSR, IRS1, AKT2 481 37 13528 6.081025 0.658937 0.001822 0.511377 pathway
GO:0001667~ameboidal cell migration 2.77E-04 EDNRB, RET, CXCR4, EFNB1, GBX2, KITLG, PAX3, ACVR1 481 37 13528 6.081025 0.658937 0.001822 0.511377
GO:0070227~lymphocyte apoptosis 2.77E-04 AKT1, IL2RA, BAX, FAS, MYC 481 10 13528 14.06237 0.659598 0.001822 0.512297
GO:0001953~negative regulation of 2.77E-04 CDKN2A, NF2, MMP14, PTEN, RASA1 481 10 13528 14.06237 0.659598 0.001822 0.512297 cell-matrix adhesion
GO:0043550~regulation of lipid kinase 2.77E-04 RBL2, RBL1, RB1, IRS1, TGFB1 481 10 13528 14.06237 0.659598 0.001822 0.512297 activity
GO:0048875~chemical homeostasis within 2.77E-04 PTHLH, PLA2G4A, ERBB4, VEGFA, KDR 481 10 13528 14.06237 0.659598 0.001822 0.512297 a tissue
GO:0043129~surfactant homeostasis 2.77E-04 PTHLH, PLA2G4A, ERBB4, VEGFA, KDR 481 10 13528 14.06237 0.659598 0.001822 0.512297
GO:0045725~positive regulation of 2.77E-04 AKT1, INS, IGF2, INSR, IRS1, AKT2 481 10 13528 14.06237 0.659598 0.001822 0.512297 glycogen biosynthetic process
GO:0009636~response to toxin 2.78E-04 ATP7A, FOS, CDKN1A, LYN, BCL2, BAX, FAS, IKBKB, SRF, HDAC6 481 61 13528 4.610613 0.660193 0.001822 0.513126
GO:0042391~regulation of membrane 2.88E-04 CAV1, EGR2, HTT, ERBB2, SNCA, GRIN1, TGFB1, PSEN1, TSC1, BAX, BCL2, JUN, ILK, QKI, 481 134 13528 3.148292 0.673849 0.001888 0.532574 potential ERCC2
GO:0000279~M phase 2.92E-04 NBN, NEK1, LATS2, NIPBL, FBXO5, H2AFX, PAFAH1B1, CDCA5, FANCA, CCNA2, HELLS, APC, 481 329 13528 2.222624 0.678766 0.00191 0.539775
CDK1, PDS5B, PDS5A, CCNF, TPX2, BRCA2, BIRC5, RB1, CDC25C, CDK2, CDC25A, RAD50,
NOLC1, UTP14C
GO:0045428~regulation of nitric oxide 3.03E-04 EGFR, AKT1, CAV1, TNF, INS, IGF2, JAK2, INSR 481 27 13528 7.291599 0.692297 0.001979 0.560174 biosynthetic process
GO:0002763~positive regulation of 3.22E-04 JUN, STAT5A, CSF1, KITLG, RB1, RUNX1 481 18 13528 9.374913 0.713534 0.002095 0.594061 myeloid leukocyte differentiation GO:0010469~regulation of receptor 3.22E-04 PSEN1, PSEN2, ADAM17, TGFA, PRKCD, HDAC6 481 18 13528 9.374913 0.713534 0.002095 0.594061 activity
GO:0046631~alpha-beta T cell activation 3.22E-04 ATP7A, BLM, INS, BCL2, ZAP70, IGF2, SYK 481 18 13528 9.374913 0.713534 0.002095 0.594061
GO:0060491~regulation of cell projection 3.22E-04 BBS4, PRKCQ, TGFB3, MTOR, KIT, APC 481 18 13528 9.374913 0.713534 0.002095 0.594061 assembly
GO:0002285~lymphocyte activation 3.22E-04 ATP7A, PSEN1, PSEN2, PLCG2, TP53, ADA 481 18 13528 9.374913 0.713534 0.002095 0.594061 during immune response
GO:0001818~negative regulation of 3.29E-04 NOD2, TNF, HSF1, PPARG, ADAM17, RARA, NFKB1, FOXP3 481 38 13528 5.920998 0.721639 0.00214 0.607659 cytokine production
GO:0045767~regulation of anti-apoptosis 3.29E-04 CDKN1A, CAV1, ERBB4, BAX, RARA, SMAD1, SIRT1, RASA1 481 38 13528 5.920998 0.721639 0.00214 0.607659
GO:0051493~regulation of cytoskeleton 3.36E-04 XPO1, CAV1, NF2, SMAD3, BRCA1, PRKCQ, CDKN1B, TSC1, TSC2, ILK, SPTBN1, MTOR, RASA1, 481 136 13528 3.101993 0.729243 0.002182 0.620779 organization APC, HDAC6
GO:0007265~Ras protein signal 3.39E-04 HRAS, GRB2, IGF1, MAPK11, ABCA1, SRC, MAPK1, CRKL, APOE, RASSF1, SOS1, MAPK14, FGF2 481 105 13528 3.482111 0.732196 0.002197 0.625972 transduction
GO:0045765~regulation of angiogenesis 3.56E-04 TNFRSF1A, HHEX, ID1, ERBB2, GATA4, SPHK1, NOS3, MAPK7, RUNX1, FGF2 481 63 13528 4.464244 0.749345 0.002303 0.657312
GO:0031098~stress-activated protein 3.56E-04 WNT5A, CRKL, TNF, ROR2, MAPK9, MAP4K1, MAPK8, MAP2K7, DAXX, SYK 481 63 13528 4.464244 0.749345 0.002303 0.657312 kinase signaling pathway
GO:0035051~cardiac cell differentiation 3.74E-04 BMP2, TSC1, RXRA, RARB, NRG1, NKX2-5, TGFB2 481 28 13528 7.031185 0.766747 0.002419 0.691375
GO:0010811~positive regulation of 3.74E-04 CD36, TSC1, CSF1, ILK, SMAD3, CDK6, SPP1 481 28 13528 7.031185 0.766747 0.002419 0.691375 cell-substrate adhesion
GO:0000723~telomere maintenance 3.74E-04 XRCC5, NBN, DKC1, BLM, PRKDC, RAD50, TERT 481 28 13528 7.031185 0.766747 0.002419 0.691375
GO:0007595~lactation 3.74E-04 PTHLH, CAV1, PRLR, SLC6A3, STAT5A, MET, STAT5B 481 28 13528 7.031185 0.766747 0.002419 0.691375
GO:0045833~negative regulation of lipid 3.74E-04 AKT1, TNF, INS, APOE, NFKB1, IGF2, GFI1, BRCA1 481 28 13528 7.031185 0.766747 0.002419 0.691375 metabolic process
GO:0010623~developmental programmed 4.21E-04 BAX, PRKDC, FASLG, KIT 481 5 13528 22.49979 0.805286 0.002714 0.776815 cell death GO:0002326~B cell lineage commitment 4.21E-04 BCL2, TP53, PRKDC, RAG2 481 5 13528 22.49979 0.805286 0.002714 0.776815
GO:0032331~negative regulation of 4.21E-04 PTHLH, BMP4, SOX9, GLI2 481 5 13528 22.49979 0.805286 0.002714 0.776815 chondrocyte differentiation
GO:0002360~T cell lineage commitment 4.21E-04 BCL2, TP53, PRKDC, RAG2 481 5 13528 22.49979 0.805286 0.002714 0.776815
GO:0045136~development of secondary 4.21E-04 STAT5A, BAX, STAT5B, NKX2-1 481 5 13528 22.49979 0.805286 0.002714 0.776815 sexual characteristics
GO:0010656~negative regulation of 4.21E-04 ILK, IGF1, NRG1, NKX2-5 481 5 13528 22.49979 0.805286 0.002714 0.776815 muscle cell apoptosis
GO:0060056~mammary gland involution 4.21E-04 CAV1, ELF3, ERBB3, ERBB2 481 5 13528 22.49979 0.805286 0.002714 0.776815
GO:0007494~midgut development 4.21E-04 ALDH1A2, EDNRB, RET, RXRA 481 5 13528 22.49979 0.805286 0.002714 0.776815
GO:0021602~cranial nerve morphogenesis 4.23E-04 HOXA1, HOXB1, EGR2, GLI3, EPHB2 481 11 13528 12.78397 0.807217 0.002726 0.781528
GO:0060043~regulation of cardiac muscle 4.23E-04 NOG, GATA4, TGFBR2, NRG1, FGF2 481 11 13528 12.78397 0.807217 0.002726 0.781528 cell proliferation
GO:0031293~membrane protein 4.23E-04 PSEN1, PSEN2, ADAM17, NFKB1, NGFR 481 11 13528 12.78397 0.807217 0.002726 0.781528 intracellular domain proteolysis
GO:0055021~regulation of cardiac muscle 4.23E-04 NOG, GATA4, TGFBR2, NRG1, FGF2 481 11 13528 12.78397 0.807217 0.002726 0.781528 growth
GO:0051897~positive regulation of 4.23E-04 INS, ILK, IGF2, MTOR, INSR, TGFB1 481 11 13528 12.78397 0.807217 0.002726 0.781528 protein kinase B signaling cascade
GO:0046902~regulation of mitochondrial 4.23E-04 BID, HTT, BCL2, BAX, TP53 481 11 13528 12.78397 0.807217 0.002726 0.781528 membrane permeability
GO:0055024~regulation of cardiac muscle 4.23E-04 NOG, GATA4, TGFBR2, NRG1, FGF2 481 11 13528 12.78397 0.807217 0.002726 0.781528 tissue development
GO:0051492~regulation of stress fiber 4.24E-04 PRKCQ, NF2, TSC1, TSC2, SMAD3, MTOR 481 19 13528 8.881497 0.807483 0.002724 0.782181 formation
GO:0046626~regulation of insulin 4.24E-04 INS, SOCS1, TSC2, IGF2, PRKCD, IRS1, SRC 481 19 13528 8.881497 0.807483 0.002724 0.782181 receptor signaling pathway
GO:0007530~sex determination 4.24E-04 IGF1R, AR, SOX9, INSR, WT1, NR5A1 481 19 13528 8.881497 0.807483 0.002724 0.782181
GO:0001502~cartilage condensation 4.24E-04 CTGF, MYF5, ROR2, COL2A1, SOX9, BMPR1B 481 19 13528 8.881497 0.807483 0.002724 0.782181
GO:0045168~cell-cell signaling involved 4.24E-04 BMP4, SIX1, POU2F1, NKX2-1, FGF10, FGF2 481 19 13528 8.881497 0.807483 0.002724 0.782181 in cell fate specification
GO:0031128~developmental induction 4.24E-04 BMP4, SIX1, POU2F1, NKX2-1, FGF10, FGF2 481 19 13528 8.881497 0.807483 0.002724 0.782181
GO:0007219~Notch signaling pathway 4.51E-04 NOTCH1, PSEN1, PSEN2, DLL3, ADAM17, FOXC2, TP63, FOXC1, NRG1 481 52 13528 4.867743 0.827014 0.002896 0.832755
GO:0046546~development of primary 4.52E-04 ACVR2A, CCND1, AR, BCL2, BAX, NKX2-1, SOX9, FANCA, WT1, NR5A1 481 65 13528 4.326883 0.827179 0.002893 0.833208 male sexual characteristics
GO:0001841~neural tube formation 4.57E-04 MAP3K7, BBS4, TSC1, TSC2, CASP8, TFAP2A, APAF1, PAX3 481 40 13528 5.624948 0.830876 0.002923 0.843427
GO:0021953~central nervous system 4.57E-04 ATP7A, HOXA1, PTK2, DRD2, FOXG1, PAFAH1B1, GLI2, EPHB2 481 40 13528 5.624948 0.830876 0.002923 0.843427 neuron differentiation
GO:0032200~telomere organization 4.58E-04 XRCC5, NBN, DKC1, BLM, PRKDC, RAD50, TERT 481 29 13528 6.78873 0.831538 0.002925 0.845281
GO:0048641~regulation of skeletal muscle 4.58E-04 BMP4, HDAC4, NOTCH1, BCL2, ILK, NKX2-5, ACVR1 481 29 13528 6.78873 0.831538 0.002925 0.845281 tissue development
GO:0002253~activation of immune 4.84E-04 MAP3K7, MAPK1, PTPRC, NOD2, MYD88, PSEN1, LYN, PSEN2, PLCG2, ZAP70, TLR4, SYK 481 94 13528 3.590392 0.847863 0.003087 0.893439 response
GO:0022411~cellular component 5.15E-04 CDKN2A, BAX, PAFAH1B1, APAF1, NRG1, ENG, MYC, XRN2, TTF2 481 53 13528 4.775899 0.865136 0.003279 0.950346 disassembly
GO:0048285~organelle fission 5.29E-04 CDK1, PDS5B, PDS5A, NEK1, CCNF, TPX2, BIRC5, CDC25C, CDK2, CDC25A, LATS2, NIPBL, 481 229 13528 2.456309 0.872157 0.003361 0.975584
NOLC1, BAX, FBXO5, PAFAH1B1, CDCA5, CCNA2, HELLS, APC
GO:0002700~regulation of production of 5.35E-04 MAP3K7, STAT6, PTPRC, NOD2, TNF, IL13, FOXP3, TGFB1 481 41 13528 5.487754 0.874887 0.003391 0.98577 molecular mediator of immune response
GO:0048678~response to axon injury 5.49E-04 LYN, ERBB2, BCL2, BAX, RXRA, JAK2 481 20 13528 8.437422 0.881559 0.003474 1.011631
GO:0045685~regulation of glial cell 5.49E-04 BMP4, NOG, NOTCH1, BMP2, PPARG, DLL3 481 20 13528 8.437422 0.881559 0.003474 1.011631 differentiation GO:0033619~membrane protein 5.49E-04 PRKCQ, PSEN1, PSEN2, ADAM17, NFKB1, NGFR 481 20 13528 8.437422 0.881559 0.003474 1.011631 proteolysis
GO:0030178~negative regulation of Wnt 5.56E-04 CTNNBIP1, CCND1, GSC, NLK, TSC2, AXIN1, APC 481 30 13528 6.562439 0.884731 0.003513 1.024436 receptor signaling pathway
GO:0033044~regulation of chromosome 5.56E-04 MEN1, MLL, SNCA, DNMT1, FOXP3, PPARGC1A, MYC 481 30 13528 6.562439 0.884731 0.003513 1.024436 organization
GO:0060627~regulation of 5.81E-04 NR1H2, CAV1, PLA2G4A, CBL, SNCA, TSC2, FGF10, FGF2, PTEN, TGFB1, HIP1, SYK 481 96 13528 3.515593 0.89537 0.003664 1.070107 vesicle-mediated transport
GO:0008344~adult locomotory behavior 5.86E-04 CHD7, HTRA2, DRD2, HIPK2, SNCA, GRIN1, PAFAH1B1, PARK2, TSHR 481 54 13528 4.687457 0.897745 0.003695 1.080931
GO:0022610~biological adhesion 6.06E-04 ACHE, TNF, MAEA, ITGB4, KITLG, CASK, CTNND1, COL2A1, ITGB3, CXCR3, SOX9, SRC, VCL, 481 701 13528 1.725198 0.90533 0.003813 1.117265
PNN, PDPK1, CD44, CTGF, BCL2, ILK, AATF, SPP1, SYK, DLG1, APC, EGFR, SELP, PTPRC, RET,
SELL, EFNB1, MYF5, LEF1, HES1, JUP, CD36, HES5, TSC1, PSEN1, ROR2, ADAM17, ABL1, BMPR
GO:0007155~cell adhesion 6.08E-04 ACHE, TNF, MAEA, ITGB4, KITLG, CASK, CTNND1, COL2A1, ITGB3, CXCR3, SOX9, SRC, VCL, 481 700 13528 1.727663 0.905917 0.003817 1.120197
PNN, PDPK1, CD44, CTGF, BCL2, ILK, AATF, SPP1, SYK, DLG1, APC, EGFR, SELP, PTPRC, RET,
SELL, EFNB1, MYF5, LEF1, HES1, JUP, CD36, HES5, TSC1, PSEN1, ROR2, ADAM17, ABL1, BMPR
GO:0051926~negative regulation of 6.17E-04 NOS1, DRD2, BCL2, NOS3, TGFB1 481 12 13528 11.71864 0.909333 0.003871 1.137621 calcium ion transport
GO:0007431~salivary gland development 6.17E-04 EGFR, PAX6, TGFB3, TGFB1, TGFB2 481 12 13528 11.71864 0.909333 0.003871 1.137621
GO:0060420~regulation of heart growth 6.17E-04 NOG, GATA4, TGFBR2, NRG1, FGF2 481 12 13528 11.71864 0.909333 0.003871 1.137621
GO:0045931~positive regulation of 6.17E-04 STAT5A, STAT5B, SPHK1, BRCA2, BIRC5 481 12 13528 11.71864 0.909333 0.003871 1.137621 mitotic cell cycle
GO:0030878~thyroid gland development 6.17E-04 HHEX, PAX8, SIX1, NKX2-1, NKX2-5 481 12 13528 11.71864 0.909333 0.003871 1.137621
GO:0006110~regulation of glycolysis 6.17E-04 HDAC4, INS, IGF1, IGF2, INSR, ARNT 481 12 13528 11.71864 0.909333 0.003871 1.137621
GO:0046006~regulation of activated T cell 6.17E-04 IL2RA, IL18, STAT5A, STAT5B, FOXP3 481 12 13528 11.71864 0.909333 0.003871 1.137621 proliferation
GO:0031647~regulation of protein 6.22E-04 GTPBP4, CDKN2A, BCL2, PRKDC, SOX4, PPARGC1A, PRKCD, PTEN 481 42 13528 5.357093 0.911013 0.003894 1.146434 stability
GO:0046651~lymphocyte proliferation 6.22E-04 PTPRC, CXCR4, BCL2, BAX, TP53, RAG2, PRKCD, HELLS 481 42 13528 5.357093 0.911013 0.003894 1.146434
GO:0043270~positive regulation of ion 6.22E-04 AKT1, CAV1, BAX, PLCG2, IL13, NKX2-5, F2R, AKT2 481 42 13528 5.357093 0.911013 0.003894 1.146434 transport
GO:0007605~sensory perception of sound 6.34E-04 EYA1, CDKN1B, CHD7, MYO6, MKKS, COL2A1, COL1A1, PAX3, TBL1X, MYC, AXIN1, FBXO11 481 97 13528 3.479349 0.915128 0.003964 1.168738
GO:0043123~positive regulation of 6.34E-04 MAP3K7, TNFRSF1A, IKBKE, NOD2, TNF, MYD88, REL, CASP8, FASLG, FADD, TLR4, F2R 481 97 13528 3.479349 0.915128 0.003964 1.168738
I-kappaB kinase/NF-kappaB cascade
GO:0051048~negative regulation of 6.65E-04 TNF, ERBB3, INS, DRD2, PTGS1, FST, IGF2, NRG1, FOXP3, ADA 481 55 13528 4.60223 0.924768 0.004151 1.225519 secretion
GO:0042509~regulation of tyrosine 6.69E-04 CAV1, NF2, LYN, SOCS1, IGF1, JAK2, GHR 481 31 13528 6.350748 0.925717 0.004164 1.23149 phosphorylation of STAT protein
GO:0022613~ribonucleoprotein complex 6.82E-04 EIF6, GTPBP4, TBL3, UTP15, HEATR1, CDKN2A, WDR36, DKC1, NOLC1, TSC1, WDR3, AATF, 481 180 13528 2.656225 0.929607 0.004244 1.256808 biogenesis POP4, UTP14A, TFB1M, IMP4, UTP14C
GO:0051318~G1 phase 6.99E-04 E2F1, CDKN1C, CDK6, RB1, CDC25C, CDK2 481 21 13528 8.03564 0.934078 0.004341 1.28769
GO:0045923~positive regulation of fatty 6.99E-04 NR1H2, PLA2G4A, PPARG, PPARGC1A, IRS1, AKT2 481 21 13528 8.03564 0.934078 0.004341 1.28769 acid metabolic process
GO:0032231~regulation of actin filament 6.99E-04 PRKCQ, NF2, TSC1, TSC2, SMAD3, MTOR 481 21 13528 8.03564 0.934078 0.004341 1.28769 bundle formation
GO:0045429~positive regulation of nitric 6.99E-04 EGFR, AKT1, TNF, INS, IGF2, JAK2, INSR 481 21 13528 8.03564 0.934078 0.004341 1.28769 oxide biosynthetic process
GO:0010883~regulation of lipid storage 6.99E-04 NR1H2, CD36, PPARG, NFKB1, ABCA1, ITGB3 481 21 13528 8.03564 0.934078 0.004341 1.28769
GO:0030218~erythrocyte differentiation 7.21E-04 BMP4, TAL1, MAEA, LYN, VEGFA, SMAD5, RB1, ERCC2 481 43 13528 5.23251 0.939364 0.004467 1.327006
GO:0019932~second-messenger-mediated 7.25E-04 EGFR, TBL3, TNF, CCKBR, DRD2, ERBB2, SPHK1, PTH1R, IGF1, FZD2, BTK, PTHLH, EDNRB, 481 235 13528 2.393595 0.940364 0.004487 1.334828 signaling IGF1R, CD36, APOE, TOP2A, TSHR, EIF2AK3, F2R
GO:0009408~response to heat 7.53E-04 AKT1, PRKCQ, PLA2G4A, NOS1, HSF1, LYN, BCL2, HSPB2, NOS3 481 56 13528 4.520048 0.946419 0.004649 1.385156
GO:0042542~response to hydrogen 7.53E-04 PLA2G4A, EP300, ERBB4, JUN, BCL2, COL1A1, STAT1, ADA, HDAC6 481 56 13528 4.520048 0.946419 0.004649 1.385156 peroxide
GO:0034613~cellular protein localization 7.56E-04 BID, XPO1, BBS4, TNF, PAX6, TGFB3, FGF10, GLI3, TGFB1, TGFB2, AKT1, NUP214, SCG5, FGF2, 481 411 13528 1.984471 0.947055 0.004661 1.390776
EGFR, MYO6, HTT, TP53, MAPK1, VCP, ID1, JUN, BAX, TSC2, SPTBN1, JAK2, NR5A1, F2R,
HDAC6
GO:0051153~regulation of striated muscle 7.99E-04 BMP4, HDAC4, NOTCH1, BCL2, ILK, NRG1, NKX2-5 481 32 13528 6.152287 0.955194 0.004917 1.469185 cell differentiation
GO:0021954~central nervous system 7.99E-04 ATP7A, PTK2, DRD2, FOXG1, PAFAH1B1, GLI2, EPHB2 481 32 13528 6.152287 0.955194 0.004917 1.469185 neuron development
GO:0045586~regulation of gamma-delta T 8.20E-04 PTPRC, STAT5A, STAT5B, SYK 481 6 13528 18.74983 0.958697 0.005038 1.507412 cell differentiation
GO:0048341~paraxial mesoderm 8.20E-04 HTT, FOXC2, LEF1, FOXC1 481 6 13528 18.74983 0.958697 0.005038 1.507412 formation
GO:0046645~positive regulation of 8.20E-04 PTPRC, STAT5A, STAT5B, SYK 481 6 13528 18.74983 0.958697 0.005038 1.507412 gamma-delta T cell activation
GO:0060390~regulation of SMAD protein 8.20E-04 BMP4, SMAD4, TGFB3, TGFB1 481 6 13528 18.74983 0.958697 0.005038 1.507412 nuclear translocation
GO:0051797~regulation of hair follicle 8.20E-04 TNF, FST, NGFR, TGFB2 481 6 13528 18.74983 0.958697 0.005038 1.507412 development
GO:0046643~regulation of gamma-delta T 8.20E-04 PTPRC, STAT5A, STAT5B, SYK 481 6 13528 18.74983 0.958697 0.005038 1.507412 cell activation
GO:0060443~mammary gland 8.20E-04 CAV1, ELF3, ERBB3, ERBB2 481 6 13528 18.74983 0.958697 0.005038 1.507412 morphogenesis
GO:0060391~positive regulation of 8.20E-04 BMP4, SMAD4, TGFB3, TGFB1 481 6 13528 18.74983 0.958697 0.005038 1.507412
SMAD protein nuclear translocation
GO:0042634~regulation of hair cycle 8.20E-04 TNF, FST, NGFR, TGFB2 481 6 13528 18.74983 0.958697 0.005038 1.507412
GO:0007252~I-kappaB phosphorylation 8.20E-04 MAP3K7, IKBKAP, IKBKB, CHUK 481 6 13528 18.74983 0.958697 0.005038 1.507412 GO:0045588~positive regulation of 8.20E-04 PTPRC, STAT5A, STAT5B, SYK 481 6 13528 18.74983 0.958697 0.005038 1.507412 gamma-delta T cell differentiation
GO:0042416~dopamine biosynthetic 8.20E-04 SLC6A3, SNCA, GCH1, TGFB2 481 6 13528 18.74983 0.958697 0.005038 1.507412 process
GO:0021548~pons development 8.20E-04 HOXA1, HOXB1, BCL2, GRIN1 481 6 13528 18.74983 0.958697 0.005038 1.507412
GO:0060395~SMAD protein signal 8.20E-04 FOS, JUN, HIPK2, SMAD4 481 6 13528 18.74983 0.958697 0.005038 1.507412 transduction
GO:0003001~generation of a signal 8.30E-04 BDNF, MYO6, PSEN1, LYN, HTT, NEUROD1, SMAD2, LRP2, EIF2AK3, SNAP25, SYK 481 85 13528 3.639672 0.960397 0.005096 1.527141 involved in cell-cell signaling
GO:0048593~camera-type eye 8.31E-04 BMP4, BAX, VEGFA, GDF11, POU2F1, ZEB1, GLI3, EPHB2 481 44 13528 5.113589 0.960565 0.005095 1.529128 morphogenesis
GO:0070727~cellular macromolecule 8.42E-04 BID, XPO1, BBS4, TNF, PAX6, TGFB3, FGF10, GLI3, TGFB1, TGFB2, AKT1, NUP214, SCG5, FGF2, 481 414 13528 1.97009 0.962202 0.005153 1.549026 localization EGFR, MYO6, HTT, TP53, MAPK1, VCP, ID1, JUN, BAX, TSC2, SPTBN1, JAK2, NR5A1, F2R,
HDAC6
GO:0048738~cardiac muscle tissue 8.49E-04 TSC1, RXRA, FOXC2, FOXC1, RARB, NRG1, NKX2-5, PTEN, TGFB2 481 57 13528 4.440748 0.963148 0.005185 1.560923 development
GO:0007067~mitosis 8.65E-04 CDK1, PDS5B, PDS5A, NEK1, CCNF, TPX2, BIRC5, CDC25C, CDK2, LATS2, CDC25A, NIPBL, 481 220 13528 2.428955 0.965429 0.005277 1.5909
NOLC1, FBXO5, PAFAH1B1, CDCA5, CCNA2, HELLS, APC
GO:0000280~nuclear division 8.65E-04 CDK1, PDS5B, PDS5A, NEK1, CCNF, TPX2, BIRC5, CDC25C, CDK2, LATS2, CDC25A, NIPBL, 481 220 13528 2.428955 0.965429 0.005277 1.5909
NOLC1, FBXO5, PAFAH1B1, CDCA5, CCNA2, HELLS, APC
GO:0042522~regulation of tyrosine 8.67E-04 CAV1, NF2, IGF1, JAK2, GHR 481 13 13528 10.81721 0.965651 0.005278 1.593912 phosphorylation of Stat5 protein
GO:0042474~middle ear morphogenesis 8.67E-04 HOXA2, EYA1, NOG, NKX3-2, MYC 481 13 13528 10.81721 0.965651 0.005278 1.593912
GO:0031572~G2/M transition DNA 8.67E-04 CDK1, NBN, BLM, CCNA2, BRCA1 481 13 13528 10.81721 0.965651 0.005278 1.593912 damage checkpoint
GO:0032770~positive regulation of 8.67E-04 AKT1, TNF, INS, APOE, IGF2, GCH1 481 13 13528 10.81721 0.965651 0.005278 1.593912 monooxygenase activity
GO:0030511~positive regulation of 8.67E-04 CDKN1C, MEN1, HIPK2, ADAM17, CITED2 481 13 13528 10.81721 0.965651 0.005278 1.593912 transforming growth factor beta receptor signaling pathway
GO:0046697~decidualization 8.67E-04 VDR, PLA2G4A, EPOR, CITED2, SPP1 481 13 13528 10.81721 0.965651 0.005278 1.593912
GO:0048384~retinoic acid receptor 8.67E-04 NR1H2, ALDH1A2, RARG, RXRA, RARA 481 13 13528 10.81721 0.965651 0.005278 1.593912 signaling pathway
GO:0042100~B cell proliferation 8.67E-04 PTPRC, BCL2, BAX, RAG2, PRKCD 481 13 13528 10.81721 0.965651 0.005278 1.593912
GO:0048854~brain morphogenesis 8.67E-04 BBS4, PSEN1, PSEN2, MKKS, PAFAH1B1 481 13 13528 10.81721 0.965651 0.005278 1.593912
GO:0048709~oligodendrocyte 8.79E-04 NOTCH1, LYN, CDKN2C, SOX11, NKX2-1, ERCC2 481 22 13528 7.670384 0.967214 0.005343 1.61576 differentiation
GO:0043525~positive regulation of 8.79E-04 TNF, CASP9, JUN, BAX, TP53, TGFB2 481 22 13528 7.670384 0.967214 0.005343 1.61576 neuron apoptosis
GO:0043542~endothelial cell migration 8.79E-04 PTK2, ID1, NOS3, SRF, FGF2, PTEN 481 22 13528 7.670384 0.967214 0.005343 1.61576
GO:0002697~regulation of immune 8.93E-04 PTPRC, TNF, STAT5A, STAT5B, IL13, IGF2, FOXP3, TGFB1, STAT6, MAP3K7, NOD2, INS, SYK 481 101 13528 3.341553 0.968958 0.005419 1.641378 effector process
GO:0030534~adult behavior 9.10E-04 BBS4, CHD7, HTRA2, DRD2, MET, HIPK2, SNCA, GRIN1, PAFAH1B1, PARK2, TSHR 481 86 13528 3.59735 0.971005 0.005517 1.673354
GO:0051480~cytosolic calcium ion 9.79E-04 PTPRC, CAV1, CCKBR, DRD2, PTH1R, FZD2, CXCR3, EDNRB, CXCR4, PLCG2, EPOR, JAK2, F2R 481 118 13528 3.098488 0.977754 0.005919 1.797444 homeostasis
GO:0050954~sensory perception of 0.001052 EYA1, CDKN1B, CHD7, MYO6, MKKS, COL2A1, COL1A1, PAX3, TBL1X, MYC, AXIN1, FBXO11 481 103 13528 3.276669 0.983266 0.006351 1.930637 mechanical stimulus
GO:0000087~M phase of mitotic cell 0.001065 CDK1, PDS5B, PDS5A, NEK1, CCNF, TPX2, BIRC5, CDC25C, CDK2, LATS2, CDC25A, NIPBL, 481 224 13528 2.385581 0.98409 0.006419 1.954235 cycle NOLC1, FBXO5, PAFAH1B1, CDCA5, CCNA2, HELLS, APC
GO:0007254~JNK cascade 0.001071 WNT5A, CRKL, TNF, ROR2, MAPK9, MAP4K1, MAPK8, DAXX, SYK 481 59 13528 4.290215 0.984464 0.006446 1.965334
GO:0009954~proximal/distal pattern 0.001091 ALDH1A2, TP63, PBX1, GLI2, GLI3, APC 481 23 13528 7.336889 0.985615 0.006555 2.001308 formation GO:0043271~negative regulation of ion 0.001091 NOS1, TNF, DRD2, BCL2, NOS3, TGFB1 481 23 13528 7.336889 0.985615 0.006555 2.001308 transport
GO:0050795~regulation of behavior 0.001093 VEGFA, ADAM17, SMAD3, FGF10, ESR2, ADA, TGFB1, KDR 481 46 13528 4.891259 0.985723 0.006556 2.004829
GO:0009712~catechol metabolic process 0.001116 ATP7A, DRD2, SLC6A3, SNCA, PARK2, GCH1, TGFB2 481 34 13528 5.790388 0.986979 0.006687 2.047833
GO:0034311~diol metabolic process 0.001116 ATP7A, DRD2, SLC6A3, SNCA, PARK2, GCH1, TGFB2 481 34 13528 5.790388 0.986979 0.006687 2.047833
GO:0006584~catecholamine metabolic 0.001116 ATP7A, DRD2, SLC6A3, SNCA, PARK2, GCH1, TGFB2 481 34 13528 5.790388 0.986979 0.006687 2.047833 process
GO:0046907~intracellular transport 0.001135 BID, BBS4, XPO1, TNF, TGFB3, FGF10, ABCA1, GLI3, TGFB1, TGFB2, AKT1, NUP214, APOE, 481 657 13528 1.712313 0.987919 0.006792 2.082789
BCL2, LSG1, MKKS, PAFAH1B1, SCG5, SNAP25, FGF2, MYO6, HTT, NXF2, TP53, NXF1, WAS,
MAPK1, HHEX, CAMK4, VCP, TSC1, PSEN1, JUN, BAX, TSC2, SPTBN1, JAK2, LRP2, HDAC6, F2R
GO:0045668~negative regulation of 0.00118 MEN1, SMAD3, CDK6, CHRD, TWIST2 481 14 13528 10.04455 0.989836 0.007046 2.163383 osteoblast differentiation
GO:0046632~alpha-beta T cell 0.00118 ATP7A, BLM, BCL2, ZAP70, SYK 481 14 13528 10.04455 0.989836 0.007046 2.163383 differentiation
GO:0033135~regulation of peptidyl-serine 0.00118 CAV1, BCL2, BAX, TGFB1, AXIN1 481 14 13528 10.04455 0.989836 0.007046 2.163383 phosphorylation
GO:0002028~regulation of sodium ion 0.00118 AKT1, DRD2, NOS3, NKX2-5, AKT2 481 14 13528 10.04455 0.989836 0.007046 2.163383 transport
GO:0043526~neuroprotection 0.00118 ATP7A, ESR1, JAK2, ESR2, GHR 481 14 13528 10.04455 0.989836 0.007046 2.163383
GO:0018958~phenol metabolic process 0.001307 ATP7A, DRD2, SLC6A3, SNCA, PARK2, GCH1, TGFB2 481 35 13528 5.624948 0.993813 0.007793 2.394581
GO:0031334~positive regulation of 0.001307 CAV1, CDKN1B, MTOR, SRF, NKX2-5, HDAC6, APC 481 35 13528 5.624948 0.993813 0.007793 2.394581 protein complex assembly
GO:0045216~cell-cell junction 0.001307 NF2, TGFB3, SMAD3, TGFB1, VCL, TGFB2, APC 481 35 13528 5.624948 0.993813 0.007793 2.394581 organization
GO:0030100~regulation of endocytosis 0.001337 NR1H2, CAV1, CBL, SNCA, TSC2, FGF10, PTEN, TGFB1, HIP1 481 61 13528 4.149552 0.994484 0.007956 2.448002
GO:0050866~negative regulation of cell 0.001337 CDKN2A, IL2RA, APOE, ERBB2, NOS3, FAS, INPP5D, FOXP3, TGFB1 481 61 13528 4.149552 0.994484 0.007956 2.448002 activation
GO:0016049~cell growth 0.001337 FGFR2, FGFR1, AR, BCL2, TGFB3, MTOR, XRN2, TGFB1, TGFB2 481 61 13528 4.149552 0.994484 0.007956 2.448002
GO:0002703~regulation of leukocyte 0.001337 MAP3K7, STAT6, PTPRC, NOD2, STAT5A, STAT5B, FOXP3, TGFB1, SYK 481 61 13528 4.149552 0.994484 0.007956 2.448002 mediated immunity
GO:0001101~response to acid 0.001338 LYN, BCL2, BAX, NOS3, MTOR, SRC 481 24 13528 7.031185 0.994505 0.00795 2.449798
GO:0031952~regulation of protein amino 0.001396 PTPRC, INS, JUN, IGF2, ENG 481 7 13528 16.07128 0.995625 0.008284 2.555642 acid autophosphorylation
GO:0031058~positive regulation of 0.001396 MEN1, DNMT1, FOXP3, PPARGC1A 481 7 13528 16.07128 0.995625 0.008284 2.555642 histone modification
GO:0048103~somatic stem cell division 0.001396 NOTCH1, CDKN2A, KIT, TGFB2 481 7 13528 16.07128 0.995625 0.008284 2.555642
GO:0010149~senescence 0.001396 CDKN2A, SRF, PRKCD, TERT 481 7 13528 16.07128 0.995625 0.008284 2.555642
GO:0060558~regulation of calcidiol 0.001396 VDR, TNF, NFKB1, GFI1 481 7 13528 16.07128 0.995625 0.008284 2.555642
1-monooxygenase activity
GO:0060419~heart growth 0.001396 RXRA, FOXC2, FOXC1, TGFB2 481 7 13528 16.07128 0.995625 0.008284 2.555642
GO:0045821~positive regulation of 0.001396 INS, IGF1, IGF2, INSR, ARNT 481 7 13528 16.07128 0.995625 0.008284 2.555642 glycolysis
GO:0014065~phosphoinositide 3-kinase 0.001396 IGF1R, ERBB3, ERBB2, IRS1 481 7 13528 16.07128 0.995625 0.008284 2.555642 cascade
GO:0014855~striated muscle cell 0.001396 RXRA, FOXC2, FOXC1, TGFB2 481 7 13528 16.07128 0.995625 0.008284 2.555642 proliferation
GO:0060038~cardiac muscle cell 0.001396 RXRA, FOXC2, FOXC1, TGFB2 481 7 13528 16.07128 0.995625 0.008284 2.555642 proliferation
GO:0002320~lymphoid progenitor cell 0.001396 BCL2, PRKDC, SOX4, KIT 481 7 13528 16.07128 0.995625 0.008284 2.555642 differentiation
GO:0055017~cardiac muscle tissue 0.001396 RXRA, FOXC2, FOXC1, TGFB2 481 7 13528 16.07128 0.995625 0.008284 2.555642 growth GO:0046668~regulation of retinal cell 0.001396 BDNF, BCL2, BAX, FGF2 481 7 13528 16.07128 0.995625 0.008284 2.555642 programmed cell death
GO:0045579~positive regulation of B cell 0.001396 STAT5A, STAT5B, INPP5D, SYK 481 7 13528 16.07128 0.995625 0.008284 2.555642 differentiation
GO:0021783~preganglionic 0.001396 HES1, HOXA1, HOXB1, EGR2 481 7 13528 16.07128 0.995625 0.008284 2.555642 parasympathetic nervous system development
GO:0034660~ncRNA metabolic process 0.001439 RPP38, RPP25, TBL3, UTP15, HEATR1, CDKN2A, WDR36, DKC1, NOLC1, POP1, RPP30, WDR3, 481 230 13528 2.323348 0.996286 0.00852 2.631755
POP4, POP5, UTP14A, TFB1M, IMP4, POP7, UTP14C
GO:0046634~regulation of alpha-beta T 0.001523 PTPRC, BLM, TGFBR2, ZAP70, RARA, ADA, SYK 481 36 13528 5.468699 0.997323 0.009002 2.78352 cell activation
GO:0030193~regulation of blood 0.001523 SELP, CAV1, APOE, NOS3, TLR4, PLAU, F2R 481 36 13528 5.468699 0.997323 0.009002 2.78352 coagulation
GO:0019218~regulation of steroid 0.001523 TNF, APOE, STAT5A, STAT5B, NFKB1, GFI1, NR5A1 481 36 13528 5.468699 0.997323 0.009002 2.78352 metabolic process
GO:0030521~androgen receptor signaling 0.001523 CCNE1, AR, RB1, PPARGC1A, DAXX, BRCA1, MED1 481 36 13528 5.468699 0.997323 0.009002 2.78352 pathway
GO:0032369~negative regulation of lipid 0.001564 NR1H2, AKT1, NFKB1, ITGB3, AKT2 481 15 13528 9.374913 0.997722 0.009232 2.858371 transport
GO:0042771~DNA damage response, 0.001564 HIPK1, HIPK2, TP53, TP63, BRCA2 481 15 13528 9.374913 0.997722 0.009232 2.858371 signal transduction by p53 class mediator resulting in induction of apoptosis
GO:0001893~maternal placenta 0.001564 VDR, PLA2G4A, EPOR, CITED2, SPP1 481 15 13528 9.374913 0.997722 0.009232 2.858371 development
GO:0002460~adaptive immune response 0.001567 NBN, NOD2, MYD88, IL18, VEGFA, ADAM17, TLR4, FAS, INPP5D, PRKCD 481 77 13528 3.652564 0.997744 0.009233 2.862708 based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0002250~adaptive immune response 0.001567 NBN, NOD2, MYD88, IL18, VEGFA, ADAM17, TLR4, FAS, INPP5D, PRKCD 481 77 13528 3.652564 0.997744 0.009233 2.862708
GO:0032886~regulation of 0.0016 BBS4, XPO1, CAV1, CDKN1B, MKKS, BRCA1, HDAC6, APC 481 49 13528 4.591794 0.998021 0.009416 2.923513 microtubule-based process
GO:0034101~erythrocyte homeostasis 0.0016 BMP4, TAL1, MAEA, LYN, VEGFA, SMAD5, RB1, ERCC2 481 49 13528 4.591794 0.998021 0.009416 2.923513
GO:0043331~response to dsRNA 0.001624 MAPK1, NOD2, SMAD3, SMAD2, SMAD1, STAT1 481 25 13528 6.749938 0.998197 0.009542 2.96663
GO:0019827~stem cell maintenance 0.001624 NOG, CREBBP, TCL1A, IGF1, KIT, APC 481 25 13528 6.749938 0.998197 0.009542 2.96663
GO:0048742~regulation of skeletal muscle 0.001624 BMP4, HDAC4, NOTCH1, BCL2, ILK, NKX2-5 481 25 13528 6.749938 0.998197 0.009542 2.96663 fiber development
GO:0007204~elevation of cytosolic 0.001802 EDNRB, PTPRC, CCKBR, CXCR4, DRD2, PLCG2, PTH1R, EPOR, JAK2, CXCR3, FZD2, F2R 481 110 13528 3.068153 0.999097 0.010564 3.285535 calcium ion concentration
GO:0001764~neuron migration 0.001832 PTK2, PSEN1, CXCR4, BAX, MET, PAX6, NKX2-1, PAFAH1B1, ESR2 481 64 13528 3.955042 0.999197 0.010724 3.339847
GO:0048864~stem cell development 0.001953 NOG, CREBBP, TCL1A, IGF1, KIT, APC 481 26 13528 6.490325 0.999499 0.011413 3.557066
GO:0035137~hindlimb morphogenesis 0.001953 NOTCH1, RARG, CHD7, RARB, PITX1, MED1 481 26 13528 6.490325 0.999499 0.011413 3.557066
GO:0048146~positive regulation of 0.001953 CDKN1A, SPHK1, IGF1, CDK6, NGFR, CCNA2 481 26 13528 6.490325 0.999499 0.011413 3.557066 fibroblast proliferation
GO:0050994~regulation of lipid catabolic 0.001953 AKT1, TNF, INS, IGF2, MTOR, IRS1, AKT2 481 26 13528 6.490325 0.999499 0.011413 3.557066 process
GO:0045766~positive regulation of 0.001953 TNFRSF1A, GATA4, SPHK1, NOS3, RUNX1, FGF2 481 26 13528 6.490325 0.999499 0.011413 3.557066 angiogenesis
GO:0007292~female gamete generation 0.002026 PLA2G4A, BCL2, LEPR, BRCA2, FBXO5, NOS3, BMPR1B, SIRT1, AXIN1 481 65 13528 3.894195 0.999622 0.011817 3.686821
GO:0031576~G2/M transition checkpoint 0.002028 CDK1, NBN, BLM, CCNA2, BRCA1 481 16 13528 8.788981 0.999625 0.011811 3.690293
GO:0045577~regulation of B cell 0.002028 PTPRC, STAT5A, STAT5B, INPP5D, SYK 481 16 13528 8.788981 0.999625 0.011811 3.690293 differentiation
GO:0043471~regulation of cellular 0.002028 HDAC4, INS, IGF1, IGF2, INSR, ARNT 481 16 13528 8.788981 0.999625 0.011811 3.690293 carbohydrate catabolic process
GO:0043470~regulation of carbohydrate 0.002028 HDAC4, INS, IGF1, IGF2, INSR, ARNT 481 16 13528 8.788981 0.999625 0.011811 3.690293 catabolic process
GO:0042552~myelination 0.002033 EGR2, TSC1, ERBB2, ILK, QKI, TGFB1, ERCC2 481 38 13528 5.180873 0.999633 0.011824 3.699667
GO:0030857~negative regulation of 0.002176 CAV1, CCND1, TP63, ZEB1 481 8 13528 14.06237 0.999789 0.012631 3.954649 epithelial cell differentiation
GO:0048857~neural nucleus development 0.002176 HOXA1, HOXB1, BCL2, FOXP2 481 8 13528 14.06237 0.999789 0.012631 3.954649
GO:0010660~regulation of muscle cell 0.002176 ILK, IGF1, NRG1, NKX2-5 481 8 13528 14.06237 0.999789 0.012631 3.954649 apoptosis
GO:0031998~regulation of fatty acid 0.002176 AKT1, MTOR, IRS1, AKT2 481 8 13528 14.06237 0.999789 0.012631 3.954649 beta-oxidation
GO:0046321~positive regulation of fatty 0.002176 PPARG, PPARGC1A, IRS1, AKT2 481 8 13528 14.06237 0.999789 0.012631 3.954649 acid oxidation
GO:0042481~regulation of odontogenesis 0.002176 CSF1, NGFR, RUNX2, APC 481 8 13528 14.06237 0.999789 0.012631 3.954649
GO:0010543~regulation of platelet 0.002176 SELP, APOE, NOS3, TLR4 481 8 13528 14.06237 0.999789 0.012631 3.954649 activation
GO:0048486~parasympathetic nervous 0.002176 HES1, HOXA1, HOXB1, EGR2 481 8 13528 14.06237 0.999789 0.012631 3.954649 system development
GO:0045737~positive regulation of 0.002176 EGFR, AKT1, CCND1, ADAM17 481 8 13528 14.06237 0.999789 0.012631 3.954649 cyclin-dependent protein kinase activity
GO:0046883~regulation of hormone 0.002235 GCG, TNF, CHD7, DRD2, FST, NEUROD1, SCG5, JAK2, SNAP25 481 66 13528 3.835192 0.999833 0.012955 4.060713 secretion
GO:0006576~biogenic amine metabolic 0.002289 ATP7A, PLA2G4A, ACHE, DRD2, SLC6A3, SNCA, PAFAH1B1, DHPS, PARK2, GCH1, TGFB2 481 97 13528 3.189404 0.999865 0.013246 4.156525 process
GO:0021510~spinal cord development 0.002332 PAX7, GDF11, PAX3, GLI2, GLI3, CHRD, ERCC2 481 39 13528 5.04803 0.999885 0.013472 4.232626
GO:0006575~cellular amino acid 0.002376 ACHE, HTT, DRD2, SLC6A3, STAT5A, STAT5B, SNCA, PARK2, GCH1, TGFB2, ATP7A, PLA2G4A, 481 166 13528 2.541392 0.999903 0.013704 4.310776 derivative metabolic process PAFAH1B1, DHPS, GHR
GO:0048547~gut morphogenesis 0.002578 NOTCH1, BCL2, GATA4, GLI2, GLI3 481 17 13528 8.271982 0.999956 0.014841 4.669374
GO:0043409~negative regulation of 0.002578 MEN1, AKT1, CAV1, NF2, APC 481 17 13528 8.271982 0.999956 0.014841 4.669374
MAPKKK cascade
GO:0070555~response to interleukin-1 0.002578 HDAC4, MYD88, SNCA, SRC, GHR 481 17 13528 8.271982 0.999956 0.014841 4.669374
GO:0007173~epidermal growth factor 0.002753 EGFR, GRB2, CBL, ADAM17, SRC, TGFB1 481 28 13528 6.02673 0.999978 0.015818 4.978676 receptor signaling pathway
GO:0030888~regulation of B cell 0.002753 PTPRC, CDKN1A, CDKN2A, IL13, INPP5D, ADA 481 28 13528 6.02673 0.999978 0.015818 4.978676 proliferation
GO:0002706~regulation of lymphocyte 0.002834 MAP3K7, STAT6, PTPRC, NOD2, STAT5A, STAT5B, FOXP3, TGFB1 481 54 13528 4.166628 0.999984 0.016259 5.122314 mediated immunity
GO:0043279~response to alkaloid 0.002834 DRD2, SLC6A3, BCL2, LEPR, GRIN1, PPARG, MYC, GHR 481 54 13528 4.166628 0.999984 0.016259 5.122314
GO:0007631~feeding behavior 0.002967 GCG, FOS, BDNF, CCKBR, DRD2, LEPR, GRIN1, NKX2-1, STAT3 481 69 13528 3.668444 0.99999 0.016991 5.356194
GO:0051092~positive regulation of 0.003027 PRKCQ, NOD2, TNF, MYD88, TLR4, IKBKB, TGFB1 481 41 13528 4.801785 0.999992 0.017308 5.462125
NF-kappaB transcription factor activity
GO:0002822~regulation of adaptive 0.003151 MAP3K7, STAT6, PTPRC, NOD2, RARA, FOXP3, ADA, TGFB1 481 55 13528 4.090871 0.999995 0.017981 5.678295 immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0021756~striatum development 0.003178 BBS4, HTT, MKKS, FOXP2 481 9 13528 12.49988 0.999996 0.018109 5.726254
GO:0032769~negative regulation of 0.003178 SNCA, NFKB1, GFI1, ENG 481 9 13528 12.49988 0.999996 0.018109 5.726254 monooxygenase activity
GO:0033205~cytokinesis during cell cycle 0.003178 BBS4, BRCA2, DAXX, APC 481 9 13528 12.49988 0.999996 0.018109 5.726254
GO:0022408~negative regulation of 0.003178 GTPBP4, NF2, JAK2, TGFB1 481 9 13528 12.49988 0.999996 0.018109 5.726254 cell-cell adhesion GO:0048745~smooth muscle tissue 0.003178 PDGFRB, TP63, ENG, FOXP2 481 9 13528 12.49988 0.999996 0.018109 5.726254 development
GO:0042640~anagen 0.003178 AKT1, NOTCH1, PSEN1, PSEN2 481 9 13528 12.49988 0.999996 0.018109 5.726254
GO:0050853~B cell receptor signaling 0.003178 MAPK1, PTPRC, LYN, SYK 481 9 13528 12.49988 0.999996 0.018109 5.726254 pathway
GO:0045684~positive regulation of 0.003178 NOTCH1, TNF, FST, TGFB2 481 9 13528 12.49988 0.999996 0.018109 5.726254 epidermis development
GO:0033002~muscle cell proliferation 0.003178 RXRA, FOXC2, FOXC1, TGFB2 481 9 13528 12.49988 0.999996 0.018109 5.726254
GO:0046641~positive regulation of 0.003178 PTPRC, BLM, ZAP70, SYK 481 9 13528 12.49988 0.999996 0.018109 5.726254 alpha-beta T cell proliferation
GO:0008635~activation of caspase 0.003178 CASP9, BAX, TP53, APAF1 481 9 13528 12.49988 0.999996 0.018109 5.726254 activity by cytochrome c
GO:0019934~cGMP-mediated signaling 0.003178 TBL3, CD36, APOE, FZD2 481 9 13528 12.49988 0.999996 0.018109 5.726254
GO:0051000~positive regulation of 0.003178 AKT1, INS, APOE, IGF2, GCH1 481 9 13528 12.49988 0.999996 0.018109 5.726254 nitric-oxide synthase activity
GO:0030947~regulation of vascular 0.003178 HHEX, VEGFA, FGF10, ARNT 481 9 13528 12.49988 0.999996 0.018109 5.726254 endothelial growth factor receptor signaling pathway
GO:0035019~somatic stem cell 0.003178 NOG, IGF1, KIT, APC 481 9 13528 12.49988 0.999996 0.018109 5.726254 maintenance
GO:0042104~positive regulation of 0.003178 IL2RA, IL18, STAT5A, STAT5B 481 9 13528 12.49988 0.999996 0.018109 5.726254 activated T cell proliferation
GO:0048701~embryonic cranial skeleton 0.003223 HOXA2, TGFBR2, TGFB3, FOXC2, TFAP2A 481 18 13528 7.812428 0.999996 0.018334 5.804396 morphogenesis
GO:0000080~G1 phase of mitotic cell 0.003223 E2F1, CDKN1C, CDK6, CDC25C, CDK2 481 18 13528 7.812428 0.999996 0.018334 5.804396 cycle GO:0045987~positive regulation of 0.003223 PTGS1, SPHK1, SRF, ADA, F2R 481 18 13528 7.812428 0.999996 0.018334 5.804396 smooth muscle contraction
GO:0002062~chondrocyte differentiation 0.003223 MAPK14, PTH1R, COL2A1, EIF2AK3, RUNX2 481 18 13528 7.812428 0.999996 0.018334 5.804396
GO:0033993~response to lipid 0.003223 EGFR, PPARG, TGFBR2, SMAD2, TGFB1 481 18 13528 7.812428 0.999996 0.018334 5.804396
GO:0035116~embryonic hindlimb 0.003223 NOTCH1, RARG, CHD7, RARB, MED1 481 18 13528 7.812428 0.999996 0.018334 5.804396 morphogenesis
GO:0019915~lipid storage 0.003223 CAV1, CD36, TNF, STAT5A, STAT5B 481 18 13528 7.812428 0.999996 0.018334 5.804396
GO:0043154~negative regulation of 0.003223 CDKN2D, SNCA, RAG1, BIRC5, SFN 481 18 13528 7.812428 0.999996 0.018334 5.804396 caspase activity
GO:0050921~positive regulation of 0.003231 VEGFA, ADAM17, SMAD3, FGF10, TGFB1, KDR 481 29 13528 5.818912 0.999997 0.018355 5.819031 chemotaxis
GO:0030199~collagen fibril organization 0.003231 ATP7A, FOXC2, FOXC1, COL2A1, COL1A1, TGFB2 481 29 13528 5.818912 0.999997 0.018355 5.819031
GO:0010522~regulation of calcium ion 0.003231 CAV1, NOS1, LYN, BCL2, BAX, TGFB1 481 29 13528 5.818912 0.999997 0.018355 5.819031 transport into cytosol
GO:0010975~regulation of neuron 0.003249 PTK2, PSEN1, APOE, ILK, GRIN1, SMAD1, NGFR, EPHB2, SPP1 481 70 13528 3.616038 0.999997 0.018428 5.84997 projection development
GO:0042594~response to starvation 0.003428 CAV1, PSEN1, JUN, TP53, PPARGC1A, SIRT1, HDAC6 481 42 13528 4.687457 0.999998 0.01941 6.163844
GO:0007272~ensheathment of neurons 0.003428 EGR2, TSC1, ERBB2, ILK, QKI, TGFB1, ERCC2 481 42 13528 4.687457 0.999998 0.01941 6.163844
GO:0008366~axon ensheathment 0.003428 EGR2, TSC1, ERBB2, ILK, QKI, TGFB1, ERCC2 481 42 13528 4.687457 0.999998 0.01941 6.163844
GO:0002819~regulation of adaptive 0.003493 MAP3K7, STAT6, PTPRC, NOD2, RARA, FOXP3, ADA, TGFB1 481 56 13528 4.01782 0.999999 0.019746 6.276969 immune response
GO:0010662~regulation of striated muscle 0.003681 ILK, NRG1, NKX2-5 481 3 13528 28.12474 0.999999 0.020766 6.603012 cell apoptosis
GO:0010665~regulation of cardiac muscle 0.003681 ILK, NRG1, NKX2-5 481 3 13528 28.12474 0.999999 0.020766 6.603012 cell apoptosis
GO:0010664~negative regulation of 0.003681 ILK, NRG1, NKX2-5 481 3 13528 28.12474 0.999999 0.020766 6.603012 striated muscle cell apoptosis
GO:0046449~creatinine metabolic process 0.003681 STAT5A, STAT5B, GHR 481 3 13528 28.12474 0.999999 0.020766 6.603012
GO:0032808~lacrimal gland development 0.003681 PAX6, FGF10, FOXC1 481 3 13528 28.12474 0.999999 0.020766 6.603012
GO:0001553~luteinization 0.003681 STAT5A, STAT5B, NR5A1 481 3 13528 28.12474 0.999999 0.020766 6.603012
GO:0046628~positive regulation of insulin 0.003681 INS, IGF2, IRS1, SRC 481 3 13528 28.12474 0.999999 0.020766 6.603012 receptor signaling pathway
GO:0046543~development of secondary 0.003681 STAT5A, STAT5B, NKX2-1 481 3 13528 28.12474 0.999999 0.020766 6.603012 female sexual characteristics
GO:0035284~brain segmentation 0.003681 HOXA2, EGR2, MAFB 481 3 13528 28.12474 0.999999 0.020766 6.603012
GO:0070141~response to UV-A 0.003681 EGFR, AKT1, CCND1 481 3 13528 28.12474 0.999999 0.020766 6.603012
GO:0010667~negative regulation of 0.003681 ILK, NRG1, NKX2-5 481 3 13528 28.12474 0.999999 0.020766 6.603012 cardiac muscle cell apoptosis
GO:0035234~germ cell programmed cell 0.003681 BAX, PRKDC, KIT 481 3 13528 28.12474 0.999999 0.020766 6.603012 death
GO:0035283~central nervous system 0.003681 HOXA2, EGR2, MAFB 481 3 13528 28.12474 0.999999 0.020766 6.603012 segmentation
GO:0050729~positive regulation of 0.003766 TNFRSF1A, PLA2G4A, STAT5A, STAT5B, JAK2, TLR4 481 30 13528 5.624948 1 0.021213 6.751201 inflammatory response
GO:0030510~regulation of BMP signaling 0.003766 ACVR2A, CAV1, NOG, HIPK2, ENG, CHRD 481 30 13528 5.624948 1 0.021213 6.751201 pathway
GO:0045638~negative regulation of 0.003766 MAFB, STAT5A, STAT5B, TLR4, INPP5D, RUNX1 481 30 13528 5.624948 1 0.021213 6.751201 myeloid cell differentiation
GO:0032368~regulation of lipid transport 0.003766 NR1H2, AKT1, APOE, NFKB1, ITGB3, AKT2 481 30 13528 5.624948 1 0.021213 6.751201
GO:0045768~positive regulation of 0.003766 CDKN1A, CAV1, ERBB4, SMAD1, SIRT1, RASA1 481 30 13528 5.624948 1 0.021213 6.751201 anti-apoptosis
GO:0002377~immunoglobulin production 0.003766 PTPRC, NBN, NOD2, PRKDC, FAS, RAG2 481 30 13528 5.624948 1 0.021213 6.751201 GO:0001843~neural tube closure 0.003766 BBS4, TSC1, TSC2, TFAP2A, APAF1, PAX3 481 30 13528 5.624948 1 0.021213 6.751201
GO:0060606~tube closure 0.003766 BBS4, TSC1, TSC2, TFAP2A, APAF1, PAX3 481 30 13528 5.624948 1 0.021213 6.751201
GO:0050770~regulation of axonogenesis 0.003863 PTK2, PSEN1, APOE, ILK, GRIN1, NGFR, EPHB2, SPP1 481 57 13528 3.947332 1 0.021725 6.919899
GO:0000725~recombinational repair 0.003969 BLM, HUS1, BRCA2, H2AFX, BRCA1 481 19 13528 7.401247 1 0.022281 7.102464
GO:0000724~double-strand break repair 0.003969 BLM, HUS1, BRCA2, H2AFX, BRCA1 481 19 13528 7.401247 1 0.022281 7.102464 via homologous recombination
GO:0045058~T cell selection 0.003969 PTPRC, BCL2, ZAP70, FAS, SYK 481 19 13528 7.401247 1 0.022281 7.102464
GO:0048008~platelet-derived growth 0.003969 VEGFA, PDGFRB, JAK2, PTEN, SRC 481 19 13528 7.401247 1 0.022281 7.102464 factor receptor signaling pathway
GO:0007224~smoothened signaling 0.003969 HIPK1, HIPK2, HHIP, GLI2, GLI3 481 19 13528 7.401247 1 0.022281 7.102464 pathway
GO:0006310~DNA recombination 0.004087 XRCC5, NBN, BLM, HUS1, RAG1, PRKDC, BRCA2, H2AFX, RAG2, RAD50, BRCA1 481 105 13528 2.946401 1 0.022906 7.306813
GO:0016568~chromatin modification 0.004216 SETDB1, MLL, RBL2, TAF5, CREBBP, RBL1, RB1, FOXP3, SIRT1, MEN1, HDAC4, EYA1, EP300, 481 274 13528 2.052901 1 0.023587 7.528725
CHD7, KDM2B, ATXN7, DNMT1, MLL4, HELLS, HDAC6
GO:0003018~vascular process in 0.004262 EDNRB, CAV1, APOE, VEGFA, FOXC2, NOS3, FOXC1, GCH1 481 58 13528 3.879275 1 0.02381 7.608561 circulatory system
GO:0002699~positive regulation of 0.004347 MAP3K7, PTPRC, NOD2, STAT5A, STAT5B, IL13, SYK 481 44 13528 4.47439 1 0.02424 7.752969 immune effector process
GO:0043112~receptor metabolic process 0.004362 TNF, ARRB2, SNCA, PPARG, TGFB1, GHR 481 31 13528 5.443498 1 0.024288 7.778664
GO:0002440~production of molecular 0.004362 PTPRC, NBN, NOD2, PRKDC, FAS, RAG2 481 31 13528 5.443498 1 0.024288 7.778664 mediator of immune response
GO:0050920~regulation of chemotaxis 0.004362 VEGFA, ADAM17, SMAD3, FGF10, TGFB1, KDR 481 31 13528 5.443498 1 0.024288 7.778664
GO:0050728~negative regulation of 0.004362 TNFRSF1B, IL2RA, INS, APOE, PPARG, IGF2, ADA 481 31 13528 5.443498 1 0.024288 7.778664 inflammatory response
GO:0033138~positive regulation of 0.004421 CAV1, BCL2, TGFB1, AXIN1 481 10 13528 11.2499 1 0.024581 7.880724 peptidyl-serine phosphorylation GO:0050673~epithelial cell proliferation 0.004421 BMP4, PSEN1, FGF10, KIT 481 10 13528 11.2499 1 0.024581 7.880724
GO:0032925~regulation of activin 0.004421 MEN1, ACVR2A, ACVR1B, ACVR1 481 10 13528 11.2499 1 0.024581 7.880724 receptor signaling pathway
GO:0048567~ectodermal gut 0.004421 NOTCH1, GATA4, GLI2, GLI3 481 10 13528 11.2499 1 0.024581 7.880724 morphogenesis
GO:0055012~ventricular cardiac muscle 0.004421 RXRA, RARB, NRG1, NKX2-5 481 10 13528 11.2499 1 0.024581 7.880724 cell differentiation
GO:0007439~ectodermal gut development 0.004421 NOTCH1, GATA4, GLI2, GLI3 481 10 13528 11.2499 1 0.024581 7.880724
GO:0043254~regulation of protein 0.004579 CAV1, CDKN1B, SPTBN1, MTOR, SRF, NKX2-5, MDN1, RASA1, HDAC6, APC 481 90 13528 3.124971 1 0.025417 8.151951 complex assembly
GO:0006935~chemotaxis 0.004605 HRAS, FGF10, CXCR3, TGFB2, EDNRB, MAPK1, CXCR4, MAPK14, TSC2, PDGFRB, ENG, FGF2, 481 160 13528 2.460915 1 0.025523 8.19638
PLAU, SYK
GO:0042330~taxis 0.004605 HRAS, FGF10, CXCR3, TGFB2, EDNRB, MAPK1, CXCR4, MAPK14, TSC2, PDGFRB, ENG, FGF2, 481 160 13528 2.460915 1 0.025523 8.19638
PLAU, SYK
GO:0046638~positive regulation of 0.004824 TGFBR2, ZAP70, RARA, ADA, SYK 481 20 13528 7.031185 1 0.026682 8.568804 alpha-beta T cell differentiation
GO:0051495~positive regulation of 0.004868 PRKCQ, CAV1, CDKN1B, NF2, SMAD3, MTOR, APC 481 45 13528 4.37496 1 0.026887 8.644469 cytoskeleton organization
GO:0046879~hormone secretion 0.004868 LYN, HTT, NEUROD1, SMAD2, LRP2, EIF2AK3, SNAP25 481 45 13528 4.37496 1 0.026887 8.644469
GO:0009267~cellular response to 0.005021 CAV1, PSEN1, JUN, TP53, SIRT1, HDAC6 481 32 13528 5.273389 1 0.027683 8.90432 starvation
GO:0007006~mitochondrial membrane 0.005021 BID, HTT, BCL2, BAX, SNCA, TP53 481 32 13528 5.273389 1 0.027683 8.90432 organization
GO:0001936~regulation of endothelial cell 0.005021 CAV1, APOE, VEGFA, MTOR, ENG, ARNT 481 32 13528 5.273389 1 0.027683 8.90432 proliferation
GO:0006970~response to osmotic stress 0.005021 EGFR, PDPK1, TNF, BAX, TP53, NKX2-1 481 32 13528 5.273389 1 0.027683 8.90432 GO:0032945~negative regulation of 0.005021 CDKN2A, IL2RA, ERBB2, INPP5D, FOXP3, TGFB1 481 32 13528 5.273389 1 0.027683 8.90432 mononuclear cell proliferation
GO:0050672~negative regulation of 0.005021 CDKN2A, IL2RA, ERBB2, INPP5D, FOXP3, TGFB1 481 32 13528 5.273389 1 0.027683 8.90432 lymphocyte proliferation
GO:0042246~tissue regeneration 0.005021 PRKCQ, NOTCH1, PAX7, IGF1, FGF10, PLAU 481 32 13528 5.273389 1 0.027683 8.90432
GO:0070664~negative regulation of 0.005021 CDKN2A, IL2RA, ERBB2, INPP5D, FOXP3, TGFB1 481 32 13528 5.273389 1 0.027683 8.90432 leukocyte proliferation
GO:0009880~embryonic pattern 0.005021 MEOX2, EFNB1, SMAD5, FGF10, SMAD2, SMAD1 481 32 13528 5.273389 1 0.027683 8.90432 specification
GO:0043623~cellular protein complex 0.005112 XPO1, CAV1, SMAD4, SMAD3, SMAD2, SMAD1, WAS, SRC, TGFB1, PTK2, PRLR, FBXO5, NRG1, 481 162 13528 2.430533 1 0.028135 9.057322 assembly HIP1
GO:0051168~nuclear export 0.005154 XPO1, HHEX, NUP214, TSC1, NXF2, LSG1, NXF1, TGFB1 481 60 13528 3.749965 1 0.028324 9.128444
GO:0002791~regulation of peptide 0.005435 GCG, TNF, CHD7, DRD2, NEUROD1, JAK2, SNAP25 481 46 13528 4.279852 1 0.029807 9.60292 secretion
GO:0002274~myeloid leukocyte 0.005435 LYN, CSF1, SNCA, TGFBR2, TLR4, TGFB1, LCP2 481 46 13528 4.279852 1 0.029807 9.60292 activation
GO:0001709~cell fate determination 0.005749 HES1, BMP4, HOXA2, HES5, PAX6, PAX2 481 33 13528 5.113589 1 0.031463 10.13044
GO:0014020~primary neural tube 0.005749 BBS4, TSC1, TSC2, TFAP2A, APAF1, PAX3 481 33 13528 5.113589 1 0.031463 10.13044 formation
GO:0032409~regulation of transporter 0.005749 INS, DRD2, SNCA, PLCG2, IGF2, INSR, NKX2-5 481 33 13528 5.113589 1 0.031463 10.13044 activity
GO:0010466~negative regulation of 0.005794 CDKN2D, SNCA, RAG1, BIRC5, SFN 481 21 13528 6.696367 1 0.031665 10.20658 peptidase activity
GO:0046889~positive regulation of lipid 0.005794 NR1H2, AKT1, PLA2G4A, TNF, INS, IGF2 481 21 13528 6.696367 1 0.031665 10.20658 biosynthetic process
GO:0032845~negative regulation of 0.005794 NOS1, BCL2, VEGFA, INPP5D, TGFB1 481 21 13528 6.696367 1 0.031665 10.20658 homeostatic process
GO:0001702~gastrulation with mouth 0.005794 ACVR2A, GATA4, SMAD4, CHRD, ACVR1 481 21 13528 6.696367 1 0.031665 10.20658 forming second
GO:0045933~positive regulation of 0.005794 PTGS1, SPHK1, SRF, ADA, F2R 481 21 13528 6.696367 1 0.031665 10.20658 muscle contraction
GO:0021544~subpallium development 0.00592 BBS4, HTT, MKKS, FOXP2 481 11 13528 10.22718 1 0.032298 10.41684
GO:0010885~regulation of cholesterol 0.00592 NR1H2, CD36, PPARG, ABCA1 481 11 13528 10.22718 1 0.032298 10.41684 storage
GO:0021871~forebrain regionalization 0.00592 BMP4, PAX6, NKX2-1, GLI3 481 11 13528 10.22718 1 0.032298 10.41684
GO:0031663~lipopolysaccharide-mediated 0.00592 MAPK1, MAPK14, NOS3, STAT1 481 11 13528 10.22718 1 0.032298 10.41684 signaling pathway
GO:0033081~regulation of T cell 0.00592 CDKN2A, ERBB2, ZEB1, ADA 481 11 13528 10.22718 1 0.032298 10.41684 differentiation in the thymus
GO:0014015~positive regulation of 0.00592 NOTCH1, BMP2, LYN, PPARG 481 11 13528 10.22718 1 0.032298 10.41684 gliogenesis
GO:0042423~catecholamine biosynthetic 0.00592 SLC6A3, SNCA, GCH1, TGFB2 481 11 13528 10.22718 1 0.032298 10.41684 process
GO:0048010~vascular endothelial growth 0.00592 FOXC2, PDGFRB, FOXC1, KDR 481 11 13528 10.22718 1 0.032298 10.41684 factor receptor signaling pathway
GO:0048070~regulation of pigmentation 0.00592 BCL2, BAX, KITLG, KIT 481 11 13528 10.22718 1 0.032298 10.41684 during development
GO:0043616~keratinocyte proliferation 0.00592 FST, TP63, FGF10, SFN 481 11 13528 10.22718 1 0.032298 10.41684
GO:0030238~male sex determination 0.00592 IGF1R, AR, SOX9, INSR 481 11 13528 10.22718 1 0.032298 10.41684
GO:0048520~positive regulation of 0.006548 VEGFA, ADAM17, SMAD3, FGF10, TGFB1, KDR 481 34 13528 4.963189 1 0.03562 11.45857 behavior
GO:0042108~positive regulation of 0.00671 PRKCQ, TNF, REL, STAT5A, STAT5B, TLR4, SYK 481 48 13528 4.101525 1 0.036438 11.72597 cytokine biosynthetic process
GO:0007249~I-kappaB kinase/NF-kappaB 0.006743 MAP3K7, IKBKAP, RIPK3, TLR4, IKBKB, STAT1, CHUK, BTK 481 63 13528 3.571396 1 0.036568 11.78139 cascade
GO:0045670~regulation of osteoclast 0.006887 TNF, CSF1, TLR4, INPP5D, APC 481 22 13528 6.391986 1 0.03728 12.01678 differentiation
GO:0046824~positive regulation of 0.006887 PRKCQ, TNF, SMAD3, PRKACA, GLI3 481 22 13528 6.391986 1 0.03728 12.01678 nucleocytoplasmic transport
GO:0043497~regulation of protein 0.007188 BCL2, BAX, NRG1 481 4 13528 21.09356 1 0.038832 12.51022 heterodimerization activity
GO:0021610~facial nerve morphogenesis 0.007188 HOXA1, HOXB1, EGR2 481 4 13528 21.09356 1 0.038832 12.51022
GO:0070723~response to cholesterol 0.007188 TGFBR2, SMAD2, TGFB1 481 4 13528 21.09356 1 0.038832 12.51022
GO:0045655~regulation of monocyte 0.007188 JUN, CSF1, INPP5D 481 4 13528 21.09356 1 0.038832 12.51022 differentiation
GO:0021612~facial nerve structural 0.007188 HOXA1, HOXB1, EGR2 481 4 13528 21.09356 1 0.038832 12.51022 organization
GO:0034983~peptidyl-lysine 0.007188 HDAC4, SIRT1, HDAC6 481 4 13528 21.09356 1 0.038832 12.51022 deacetylation
GO:0010940~positive regulation of 0.007188 TNF, FASLG, FAS 481 4 13528 21.09356 1 0.038832 12.51022 necrotic cell death
GO:0006549~isoleucine metabolic process 0.007188 STAT5A, STAT5B, GHR 481 4 13528 21.09356 1 0.038832 12.51022
GO:0010523~negative regulation of 0.007188 NOS1, BCL2, TGFB1 481 4 13528 21.09356 1 0.038832 12.51022 calcium ion transport into cytosol
GO:0032909~regulation of transforming 0.007188 SMAD4, SMAD3, TGFB2 481 4 13528 21.09356 1 0.038832 12.51022 growth factor-beta2 production
GO:0007095~mitotic cell cycle G2/M 0.007188 CDK1, NBN, CCNA2 481 4 13528 21.09356 1 0.038832 12.51022 transition DNA damage checkpoint GO:0051798~positive regulation of hair 0.007188 TNF, FST, TGFB2 481 4 13528 21.09356 1 0.038832 12.51022 follicle development
GO:0000255~allantoin metabolic process 0.007188 STAT5A, STAT5B, GHR 481 4 13528 21.09356 1 0.038832 12.51022
GO:0022601~menstrual cycle phase 0.007188 TGFB3, NKX2-1, TGFB2 481 4 13528 21.09356 1 0.038832 12.51022
GO:0055094~response to lipoprotein 0.007188 PPARG, ADAM17, NOS3 481 4 13528 21.09356 1 0.038832 12.51022 stimulus
GO:0021604~cranial nerve structural 0.007188 HOXA1, HOXB1, EGR2 481 4 13528 21.09356 1 0.038832 12.51022 organization
GO:0031558~induction of apoptosis in 0.007188 BAX, MAPK9, MAPK8 481 4 13528 21.09356 1 0.038832 12.51022 response to chemical stimulus
GO:0031657~regulation of 0.007188 EGFR, AKT1, ADAM17 481 4 13528 21.09356 1 0.038832 12.51022 cyclin-dependent protein kinase activity during G1/S
GO:0021569~rhombomere 3 development 0.007188 HOXA1, HOXA2, EGR2 481 4 13528 21.09356 1 0.038832 12.51022
GO:0031659~positive regulation of 0.007188 EGFR, AKT1, ADAM17 481 4 13528 21.09356 1 0.038832 12.51022 cyclin-dependent protein kinase activity during G1/S
GO:0006927~transformed cell apoptosis 0.007188 TNF, BAX, FAS 481 4 13528 21.09356 1 0.038832 12.51022
GO:0021798~forebrain dorsal/ventral 0.007188 PAX6, NKX2-1, GLI3 481 4 13528 21.09356 1 0.038832 12.51022 pattern formation
GO:0033033~negative regulation of 0.007188 MAEA, BCL2, STAT5A 481 4 13528 21.09356 1 0.038832 12.51022 myeloid cell apoptosis
GO:0060556~regulation of vitamin D 0.007188 TNF, NFKB1, GFI1 481 4 13528 21.09356 1 0.038832 12.51022 biosynthetic process
GO:0030656~regulation of vitamin 0.007188 TNF, NFKB1, GFI1 481 4 13528 21.09356 1 0.038832 12.51022 metabolic process GO:0010765~positive regulation of 0.007188 AKT1, NKX2-5, AKT2 481 4 13528 21.09356 1 0.038832 12.51022 sodium ion transport
GO:0033500~carbohydrate homeostasis 0.007423 INS, PPARG, NEUROD1, IGF2, INSR, PPARGC1A, IRS1, STAT3 481 49 13528 4.01782 1 0.040023 12.89243
GO:0042593~glucose homeostasis 0.007423 INS, PPARG, NEUROD1, IGF2, INSR, PPARGC1A, IRS1, STAT3 481 49 13528 4.01782 1 0.040023 12.89243
GO:0009914~hormone transport 0.007423 LYN, HTT, NEUROD1, SMAD2, LRP2, EIF2AK3, SNAP25 481 49 13528 4.01782 1 0.040023 12.89243
GO:0006809~nitric oxide biosynthetic 0.007688 AKT1, NOS1, NOS3, GCH1 481 12 13528 9.374913 1 0.04137 13.3223 process
GO:0010039~response to iron ion 0.007688 CCND1, SLC6A3, BCL2, SNCA 481 12 13528 9.374913 1 0.04137 13.3223
GO:0051496~positive regulation of stress 0.007688 PRKCQ, NF2, SMAD3, MTOR 481 12 13528 9.374913 1 0.04137 13.3223 fiber formation
GO:0010888~negative regulation of lipid 0.007688 NR1H2, PPARG, ABCA1, ITGB3 481 12 13528 9.374913 1 0.04137 13.3223 storage
GO:0060389~pathway-restricted SMAD 0.007688 BMP2, TGFBR2, TGFB1, TGFB2 481 12 13528 9.374913 1 0.04137 13.3223 protein phosphorylation
GO:0001958~endochondral ossification 0.007688 PTHLH, COL2A1, COL1A1, RUNX2 481 12 13528 9.374913 1 0.04137 13.3223
GO:0010745~negative regulation of foam 0.007688 NR1H2, PPARG, ABCA1, ITGB3 481 12 13528 9.374913 1 0.04137 13.3223 cell differentiation
GO:0070228~regulation of lymphocyte 0.007688 BAX, RAG1, MYC, ADA 481 12 13528 9.374913 1 0.04137 13.3223 apoptosis
GO:0021511~spinal cord patterning 0.007688 GDF11, GLI2, GLI3, CHRD 481 12 13528 9.374913 1 0.04137 13.3223
GO:0001542~ovulation from ovarian 0.007688 PLA2G4A, LEPR, NOS3, SIRT1 481 12 13528 9.374913 1 0.04137 13.3223 follicle
GO:0042058~regulation of epidermal 0.008107 PSEN1, SOS1, PSEN2, ADAM17, TGFA 481 23 13528 6.114074 1 0.043525 13.99809 growth factor receptor signaling pathway
GO:0055007~cardiac muscle cell 0.008107 TSC1, RXRA, RARB, NRG1, NKX2-5 481 23 13528 6.114074 1 0.043525 13.99809 differentiation GO:0002252~immune effector process 0.008161 PTPRC, NBN, NOD2, MYD88, LYN, BCL2, ADAM17, PRKDC, FAS, RAG2, INPP5D, PRKCD 481 134 13528 2.518633 1 0.043748 14.08443
GO:0031348~negative regulation of 0.008372 TNFRSF1B, IL2RA, INS, APOE, PPARG, IGF2, ADA 481 36 13528 4.687457 1 0.0448 14.42339 defense response
GO:0055088~lipid homeostasis 0.00901 CAV1, INS, APOE, COL4A3BP, PPARG, IGF2, ABCA1, NR5A2 481 51 13528 3.860258 1 0.048078 15.43721
GO:0043506~regulation of JUN kinase 0.009405 MAP4K1, PDCD4, DAXX, TP73, CBS, SYK 481 37 13528 4.560769 1 0.050073 16.05928 activity
GO:0045666~positive regulation of 0.009461 BDNF, FOXA2, NEUROD1, GLI2, NKX2-5 481 24 13528 5.859321 1 0.050296 16.14687 neuron differentiation
GO:0001892~embryonic placenta 0.009461 CEBPB, HSF1, MED1, ARNT, CITED2 481 24 13528 5.859321 1 0.050296 16.14687 development
GO:0016337~cell-cell adhesion 0.009714 EGFR, SELP, PTPRC, RET, TNF, MYF5, CTNND1, COL2A1, SOX9, SRC, JUP, PSEN1, CD44, CTGF, 481 276 13528 1.936123 1 0.051545 16.54393
BCL2, ROR2, BMPR1B, SYK, DLG1
GO:0002286~T cell activation during 0.009734 ATP7A, PSEN1, PSEN2, TP53 481 13 13528 8.653766 1 0.051577 16.57444 immune response
GO:0010744~positive regulation of foam 0.009734 CD36, CSF1, MAPK9, NFKB1 481 13 13528 8.653766 1 0.051577 16.57444 cell differentiation
GO:0046209~nitric oxide metabolic 0.009734 AKT1, NOS1, NOS3, GCH1 481 13 13528 8.653766 1 0.051577 16.57444 process
GO:0046640~regulation of alpha-beta T 0.009734 PTPRC, BLM, ZAP70, SYK 481 13 13528 8.653766 1 0.051577 16.57444 cell proliferation
GO:0045907~positive regulation of 0.009734 CAV1, PTGS1, ALOX5, F2R 481 13 13528 8.653766 1 0.051577 16.57444 vasoconstriction
GO:0001759~induction of an organ 0.009734 BMP4, SIX1, FGF10, FGF2 481 13 13528 8.653766 1 0.051577 16.57444
GO:0006940~regulation of smooth muscle 0.010522 CAV1, PTGS1, SPHK1, SRF, ADA, F2R 481 38 13528 4.440748 1 0.055579 17.79555 contraction
GO:0035150~regulation of tube size 0.010826 EDNRB, CAV1, APOE, FOXC2, NOS3, FOXC1, GCH1 481 53 13528 3.714588 1 0.057072 18.26271 GO:0050880~regulation of blood vessel 0.010826 EDNRB, CAV1, APOE, FOXC2, NOS3, FOXC1, GCH1 481 53 13528 3.714588 1 0.057072 18.26271 size
GO:0006898~receptor-mediated 0.010826 ARRB2, APOE, IGF2R, SNCA, TGFBR2, LRP2, GHR 481 53 13528 3.714588 1 0.057072 18.26271 endocytosis
GO:0045840~positive regulation of 0.010953 TNF, INS, TGFA, IGF1, IGF2, INSR 481 25 13528 5.624948 1 0.057648 18.45715 mitosis
GO:0051785~positive regulation of 0.010953 TNF, INS, TGFA, IGF1, IGF2, INSR 481 25 13528 5.624948 1 0.057648 18.45715 nuclear division
GO:0000186~activation of MAPKK 0.010953 EGFR, PSEN1, JAK2, FGF2, F2R 481 25 13528 5.624948 1 0.057648 18.45715 activity
GO:0050810~regulation of steroid 0.010953 TNF, APOE, NFKB1, GFI1, NR5A1 481 25 13528 5.624948 1 0.057648 18.45715 biosynthetic process
GO:0046637~regulation of alpha-beta T 0.010953 TGFBR2, ZAP70, RARA, ADA, SYK 481 25 13528 5.624948 1 0.057648 18.45715 cell differentiation
GO:0050771~negative regulation of 0.010953 PTK2, PSEN1, NGFR, EPHB2, SPP1 481 25 13528 5.624948 1 0.057648 18.45715 axonogenesis
GO:0048532~anatomical structure 0.0117 HOXA1, HOXB1, EGR2 481 5 13528 16.87484 1 0.061393 19.58951 arrangement
GO:0031953~negative regulation of 0.0117 PTPRC, JUN, ENG 481 5 13528 16.87484 1 0.061393 19.58951 protein amino acid autophosphorylation
GO:0031557~induction of programmed 0.0117 BAX, MAPK9, MAPK8 481 5 13528 16.87484 1 0.061393 19.58951 cell death in response to chemical stimulus
GO:0002246~healing during inflammatory 0.0117 CD44, TGFB1, F2R 481 5 13528 16.87484 1 0.061393 19.58951 response
GO:0042487~regulation of odontogenesis 0.0117 CSF1, NGFR, RUNX2 481 5 13528 16.87484 1 0.061393 19.58951 of dentine-containing tooth GO:0002347~response to tumor cell 0.0117 TP53, TP63, TP73 481 5 13528 16.87484 1 0.061393 19.58951
GO:0045647~negative regulation of 0.0117 MAFB, STAT5A, STAT5B 481 5 13528 16.87484 1 0.061393 19.58951 erythrocyte differentiation
GO:0048087~positive regulation of 0.0117 BCL2, BAX, KITLG 481 5 13528 16.87484 1 0.061393 19.58951 pigmentation during development
GO:0021561~facial nerve development 0.0117 HOXA1, HOXB1, EGR2 481 5 13528 16.87484 1 0.061393 19.58951
GO:0070265~necrotic cell death 0.0117 TNF, FASLG, FADD 481 5 13528 16.87484 1 0.061393 19.58951
GO:0035065~regulation of histone 0.0117 SNCA, FOXP3, PPARGC1A 481 5 13528 16.87484 1 0.061393 19.58951 acetylation
GO:0006573~valine metabolic process 0.0117 STAT5A, STAT5B, GHR 481 5 13528 16.87484 1 0.061393 19.58951
GO:0031053~primary microRNA 0.0117 SMAD3, SMAD2, SMAD1 481 5 13528 16.87484 1 0.061393 19.58951 processing
GO:0010939~regulation of necrotic cell 0.0117 TNF, FASLG, FAS 481 5 13528 16.87484 1 0.061393 19.58951 death
GO:0070231~T cell apoptosis 0.0117 AKT1, IL2RA, FAS 481 5 13528 16.87484 1 0.061393 19.58951
GO:0019530~taurine metabolic process 0.0117 STAT5A, STAT5B, GHR 481 5 13528 16.87484 1 0.061393 19.58951
GO:0051898~negative regulation of 0.0117 DRD2, TSC2, PTEN 481 5 13528 16.87484 1 0.061393 19.58951 protein kinase B signaling cascade
GO:0060632~regulation of 0.0117 BBS4, MKKS, HDAC6 481 5 13528 16.87484 1 0.061393 19.58951 microtubule-based movement
GO:0006924~activation-induced cell death 0.0117 AKT1, IL2RA, FAS 481 5 13528 16.87484 1 0.061393 19.58951 of T cells
GO:0033555~multicellular organismal 0.011726 EDNRB, BDNF, NOS1, BCL2, ESR2, GCH1 481 39 13528 4.326883 1 0.061447 19.62966 response to stress
GO:0019228~regulation of action 0.011825 EGR2, TSC1, ERBB2, ILK, QKI, TGFB1, ERCC2 481 54 13528 3.6458 1 0.061869 19.77856 potential in neuron GO:0051250~negative regulation of 0.011825 CDKN2A, IL2RA, ERBB2, FAS, INPP5D, FOXP3, TGFB1 481 54 13528 3.6458 1 0.061869 19.77856 lymphocyte activation
GO:0007229~integrin-mediated signaling 0.011835 PTK2, GAB2, CTGF, ILK, ITGB4, ITGB3, VAV1, SYK 481 70 13528 3.214256 1 0.061836 19.79322 pathway
GO:0009651~response to salt stress 0.012067 TNF, BAX, TP53, NKX2-1 481 14 13528 8.03564 1 0.062932 20.14134
GO:0032233~positive regulation of actin 0.012067 PRKCQ, NF2, SMAD3, MTOR 481 14 13528 8.03564 1 0.062932 20.14134 filament bundle formation
GO:0048844~artery morphogenesis 0.012067 APOE, FOXC2, FOXC1, ENG 481 14 13528 8.03564 1 0.062932 20.14134
GO:0030728~ovulation 0.012067 PLA2G4A, LEPR, NOS3, SIRT1 481 14 13528 8.03564 1 0.062932 20.14134
GO:0030262~apoptotic nuclear changes 0.01259 CDKN2A, BAX, APAF1, TOP2A, MYC 481 26 13528 5.408604 1 0.065497 20.92068
GO:0035303~regulation of 0.01259 TSC1, SMAD3, JAK2, TGFB1, TGFB2 481 26 13528 5.408604 1 0.065497 20.92068 dephosphorylation
GO:0000737~DNA catabolic process, 0.01259 CDKN2A, BAX, APAF1, MYC, ERCC2 481 26 13528 5.408604 1 0.065497 20.92068 endonucleolytic
GO:0000018~regulation of DNA 0.01259 STAT6, PTPRC, BLM, RAD50, TGFB1 481 26 13528 5.408604 1 0.065497 20.92068 recombination
GO:0048066~pigmentation during 0.01259 EDNRB, BCL2, KIT, PAX3, OCA2 481 26 13528 5.408604 1 0.065497 20.92068 development
GO:0046427~positive regulation of 0.01259 LYN, IGF1, JAK2, F2R, GHR 481 26 13528 5.408604 1 0.065497 20.92068
JAK-STAT cascade
GO:0002637~regulation of 0.01259 STAT6, PTPRC, TNF, IL13, TGFB1 481 26 13528 5.408604 1 0.065497 20.92068 immunoglobulin production
GO:0048015~phosphoinositide-mediated 0.012757 IGF1R, EDNRB, CCKBR, DRD2, ERBB2, PTH1R, IGF1, TOP2A, F2R 481 88 13528 2.876394 1 0.066255 21.16854 signaling
GO:0051592~response to calcium ion 0.012887 EGFR, CAV1, PLA2G4A, CCND1, EP300, HTT, AQP3 481 55 13528 3.579512 1 0.066824 21.36112
GO:0019226~transmission of nerve 0.013433 ACHE, EGR2, NOS1, MYO6, DRD2, ERBB2, GRIN1, SNCA, PARK2, TGFB1, MAPK1, PTK2, PSEN1, 481 350 13528 1.767841 1 0.069479 22.16252 impulse CAMK4, TSC1, APOE, ILK, QKI, PAFAH1B1, FGF2, SNAP25, ERCC2
GO:0032956~regulation of actin 0.013597 PRKCQ, NF2, TSC1, ILK, TSC2, SMAD3, SPTBN1, MTOR, RASA1 481 89 13528 2.844075 1 0.070211 22.40205 cytoskeleton organization
GO:0006937~regulation of muscle 0.013696 CAV1, NOS1, PTGS1, SPHK1, SRF, NKX2-5, ADA, F2R 481 72 13528 3.124971 1 0.070613 22.54608 contraction
GO:0007088~regulation of mitosis 0.014015 TNF, INS, TGFA, IGF1, IGF2, CDC25C, INSR, APC 481 56 13528 3.515593 1 0.072112 23.00836
GO:0006338~chromatin remodeling 0.014015 MEN1, HDAC4, RB1, FOXP3, SIRT1, MLL4, HELLS 481 56 13528 3.515593 1 0.072112 23.00836
GO:0051783~regulation of nuclear 0.014015 TNF, INS, TGFA, IGF1, IGF2, CDC25C, INSR, APC 481 56 13528 3.515593 1 0.072112 23.00836 division
GO:0006886~intracellular protein 0.014287 BID, XPO1, TNF, MYO6, HTT, TP53, TGFB3, FGF10, GLI3, TGFB1, TGFB2, AKT1, MAPK1, NUP214, 481 374 13528 1.729596 1 0.073376 23.40202 transport VCP, JUN, TSC2, SPTBN1, JAK2, SCG5, FGF2, F2R, HDAC6
GO:0042130~negative regulation of T cell 0.014374 CDKN2A, IL2RA, ERBB2, FOXP3, TGFB1 481 27 13528 5.208285 1 0.073712 23.52703 proliferation
GO:0008542~visual learning 0.014374 HRAS, HTT, DRD2, GRIN1, KIT 481 27 13528 5.208285 1 0.073712 23.52703
GO:0002790~peptide secretion 0.014409 HTT, NEUROD1, SMAD2, ABCA1, EIF2AK3, SNAP25 481 41 13528 4.115816 1 0.073788 23.57693
GO:0000910~cytokinesis 0.014409 BBS4, BRCA2, BIRC5, DAXX, RASA1, APC 481 41 13528 4.115816 1 0.073788 23.57693
GO:0006509~membrane protein 0.014693 PRKCQ, PSEN1, PSEN2, ADAM17 481 15 13528 7.499931 1 0.075096 23.98316 ectodomain proteolysis
GO:0021955~central nervous system 0.014693 PTK2, PAFAH1B1, GLI2, EPHB2 481 15 13528 7.499931 1 0.075096 23.98316 neuron axonogenesis
GO:0051055~negative regulation of lipid 0.014693 APOE, NFKB1, GFI1, BRCA1 481 15 13528 7.499931 1 0.075096 23.98316 biosynthetic process
GO:0007176~regulation of epidermal 0.014693 PSEN1, PSEN2, ADAM17, TGFA 481 15 13528 7.499931 1 0.075096 23.98316 growth factor receptor activity
GO:0009791~post-embryonic 0.014701 BMP4, PSEN1, BCL2, BAX, SMAD2, TP73, ERCC2, FOXP2 481 73 13528 3.082163 1 0.07504 23.99547 development GO:0031349~positive regulation of 0.014701 TNFRSF1A, PLA2G4A, NOD2, MYD88, STAT5A, STAT5B, JAK2, TLR4 481 73 13528 3.082163 1 0.07504 23.99547 defense response
GO:0002695~negative regulation of 0.015209 CDKN2A, IL2RA, ERBB2, FAS, INPP5D, FOXP3, TGFB1 481 57 13528 3.453915 1 0.077448 24.71783 leukocyte activation
GO:0070507~regulation of microtubule 0.015893 XPO1, CAV1, CDKN1B, BRCA1, HDAC6, APC 481 42 13528 4.01782 1 0.080708 25.68069 cytoskeleton organization
GO:0051591~response to cAMP 0.015893 FOS, THBD, SLC6A3, JUN, COL1A1, STAT1 481 42 13528 4.01782 1 0.080708 25.68069
GO:0031345~negative regulation of cell 0.016311 PTK2, PSEN1, NGFR, EPHB2, SPP1 481 28 13528 5.022275 1 0.082652 26.26375 projection organization
GO:0032970~regulation of actin 0.01636 PRKCQ, NF2, TSC1, ILK, TSC2, SMAD3, SPTBN1, MTOR, RASA1 481 92 13528 2.751333 1 0.082781 26.33064 filament-based process
GO:0048541~Peyer's patch development 0.01714 STAT5A, STAT5B, ADA 481 6 13528 14.06237 1 0.086474 27.40563
GO:0045922~negative regulation of fatty 0.01714 AKT1, INS, IGF2, BRCA1 481 6 13528 14.06237 1 0.086474 27.40563 acid metabolic process
GO:0010887~negative regulation of 0.01714 NR1H2, PPARG, ABCA1 481 6 13528 14.06237 1 0.086474 27.40563 cholesterol storage
GO:0007260~tyrosine phosphorylation of 0.01714 JAK2, STAT1, F2R 481 6 13528 14.06237 1 0.086474 27.40563
STAT protein
GO:0006360~transcription from RNA 0.01714 TAF1C, TCOF1, POLR1C 481 6 13528 14.06237 1 0.086474 27.40563 polymerase I promoter
GO:0060351~cartilage development 0.01714 COL2A1, COL1A1, GHR 481 6 13528 14.06237 1 0.086474 27.40563 involved in endochondral bone morphogenesis
GO:0021903~rostrocaudal neural tube 0.01714 HES1, PAX6, GBX2 481 6 13528 14.06237 1 0.086474 27.40563 patterning
GO:0007406~negative regulation of 0.01714 BDNF, TP53, TGFB1 481 6 13528 14.06237 1 0.086474 27.40563 neuroblast proliferation
GO:0031060~regulation of histone 0.01714 MEN1, MLL, DNMT1 481 6 13528 14.06237 1 0.086474 27.40563 methylation
GO:0048710~regulation of astrocyte 0.01714 NOG, BMP2, DLL3 481 6 13528 14.06237 1 0.086474 27.40563 differentiation
GO:0048537~mucosal-associated 0.01714 STAT5A, STAT5B, ADA 481 6 13528 14.06237 1 0.086474 27.40563 lymphoid tissue development
GO:0032148~activation of protein kinase 0.01714 PDPK1, INS, IGF2, INSR 481 6 13528 14.06237 1 0.086474 27.40563
B activity
GO:0000083~regulation of transcription of 0.01714 NPAT, RB1, GFI1 481 6 13528 14.06237 1 0.086474 27.40563
G1/S-phase of mitotic cell cycle
GO:0045879~negative regulation of 0.01714 HHIP, RUNX2, CHRD 481 6 13528 14.06237 1 0.086474 27.40563 smoothened signaling pathway
GO:0042532~negative regulation of 0.01714 CAV1, NF2, SOCS1 481 6 13528 14.06237 1 0.086474 27.40563 tyrosine phosphorylation of STAT protein
GO:0016044~membrane organization 0.017294 EGFR, BID, HRAS, CAV1, MYO6, HTT, SNCA, TGFBR2, LMNA, TP53, ABCA1, VAV1, CD36, 481 381 13528 1.697819 1 0.08711 27.61589
ARRB2, APOE, IGF2R, BAX, BCL2, TSC2, PAFAH1B1, LRP2, GHR, HIP1
GO:0001824~blastocyst development 0.017475 NBN, BRCA2, CAPN2, SRF, ADA, CITED2 481 43 13528 3.924382 1 0.087879 27.86359
GO:0022029~telencephalon cell migration 0.017615 PSEN1, DRD2, NKX2-1, PAFAH1B1 481 16 13528 7.031185 1 0.088444 28.05371
GO:0051148~negative regulation of 0.017615 BMP4, HDAC4, NOTCH1, NKX2-5 481 16 13528 7.031185 1 0.088444 28.05371 muscle cell differentiation
GO:0050709~negative regulation of 0.017615 TNF, INS, DRD2, IGF2, FOXP3 481 16 13528 7.031185 1 0.088444 28.05371 protein secretion
GO:0043535~regulation of blood vessel 0.017615 APOE, VEGFA, FGF2, TGFB1 481 16 13528 7.031185 1 0.088444 28.05371 endothelial cell migration
GO:0046579~positive regulation of Ras 0.017615 HRAS, ERBB2, CSF1, IGF1 481 16 13528 7.031185 1 0.088444 28.05371 protein signal transduction
GO:0001964~startle response 0.017615 DRD2, SLC6A3, GRIN1, PARK2 481 16 13528 7.031185 1 0.088444 28.05371
GO:0008543~fibroblast growth factor 0.018404 FGFR2, FGFR1, CTGF, FGF10, FGF2 481 29 13528 4.849093 1 0.092134 29.11655 receptor signaling pathway
GO:0042490~mechanoreceptor 0.018404 HES1, BDNF, MYO6, HES5, GFI1 481 29 13528 4.849093 1 0.092134 29.11655 differentiation
GO:0045807~positive regulation of 0.018404 CAV1, CBL, SNCA, FGF10, HIP1 481 29 13528 4.849093 1 0.092134 29.11655 endocytosis
GO:0010817~regulation of hormone levels 0.018738 ALDH1A2, LYN, HTT, STAT5B, NEUROD1, SCG5, SMAD2, LRP2, EIF2AK3, FGF2, SNAP25, MED1 481 151 13528 2.235079 1 0.093622 29.56241
GO:0006308~DNA catabolic process 0.019211 CDKN2A, BAX, MBD4, APAF1, MYC, XRN2, ERCC2 481 60 13528 3.28122 1 0.095768 30.18869
GO:0009743~response to carbohydrate 0.019211 PRKCQ, LYN, TGFBR2, NEUROD1, SMAD2, PTEN, TGFB1 481 60 13528 3.28122 1 0.095768 30.18869 stimulus
GO:0051260~protein 0.019506 CAV1, VCP, BAX, TSC2, TP63, FAS, PRNP, EIF2AK3, GCH1 481 95 13528 2.664449 1 0.097052 30.5757 homooligomerization
GO:0032663~regulation of interleukin-2 0.020656 MAP3K7, PRKCQ, STAT5A, STAT5B, FOXP3 481 30 13528 4.687457 1 0.102401 32.06954 production
GO:0021549~cerebellum development 0.020656 ATP7A, GBX2, NEUROD1, GLI2, FOXP2 481 30 13528 4.687457 1 0.102401 32.06954
GO:0050808~synapse organization 0.020691 ACHE, MYO6, ERBB4, TSC1, DRD2, ERBB2, F2R 481 61 13528 3.227429 1 0.102436 32.1142
GO:0051057~positive regulation of small 0.020838 HRAS, ERBB2, CSF1, IGF1 481 17 13528 6.617586 1 0.103001 32.30226
GTPase mediated signal transduction
GO:0008306~associative learning 0.020838 FOS, HTT, DRD2, GRIN1 481 17 13528 6.617586 1 0.103001 32.30226
GO:0042307~positive regulation of 0.020838 PRKCQ, TNF, SMAD3, GLI3 481 17 13528 6.617586 1 0.103001 32.30226 protein import into nucleus
GO:0021885~forebrain cell migration 0.020838 PSEN1, DRD2, NKX2-1, PAFAH1B1 481 17 13528 6.617586 1 0.103001 32.30226
GO:0042516~regulation of tyrosine 0.020838 NF2, SOCS1, JAK2, GHR 481 17 13528 6.617586 1 0.103001 32.30226 phosphorylation of Stat3 protein GO:0048873~homeostasis of number of 0.020838 BCL2, BAX, CSF1, F2R 481 17 13528 6.617586 1 0.103001 32.30226 cells within a tissue
GO:0031018~endocrine pancreas 0.020838 FOXA2, MNX1, NEUROD1, EIF2AK3 481 17 13528 6.617586 1 0.103001 32.30226 development
GO:0009749~response to glucose stimulus 0.020945 PRKCQ, TGFBR2, NEUROD1, SMAD2, PTEN, TGFB1 481 45 13528 3.749965 1 0.103378 32.43941
GO:0050905~neuromuscular process 0.022246 NBN, DRD2, SLC6A3, GRIN1, PAFAH1B1, PARK2, GCH1 481 62 13528 3.175374 1 0.109367 34.08361
GO:0007270~nerve-nerve synaptic 0.02307 CAMK4, DRD2, SNCA, GRIN1, PARK2 481 31 13528 4.536248 1 0.113085 35.10552 transmission
GO:0007632~visual behavior 0.02307 HRAS, HTT, DRD2, GRIN1, KIT 481 31 13528 4.536248 1 0.113085 35.10552
GO:0032680~regulation of tumor necrosis 0.02307 NOD2, MYD88, HSF1, RARA, TLR4 481 31 13528 4.536248 1 0.113085 35.10552 factor production
GO:0031057~negative regulation of 0.023437 SNCA, DNMT1, FOXP3 481 7 13528 12.05346 1 0.114653 35.55531 histone modification
GO:0030949~positive regulation of 0.023437 VEGFA, FGF10, ARNT 481 7 13528 12.05346 1 0.114653 35.55531 vascular endothelial growth factor receptor signaling pathway
GO:0032689~negative regulation of 0.023437 NOD2, RARA, FOXP3 481 7 13528 12.05346 1 0.114653 35.55531 interferon-gamma production
GO:0046426~negative regulation of 0.023437 CAV1, NF2, SOCS1 481 7 13528 12.05346 1 0.114653 35.55531
JAK-STAT cascade
GO:0050663~cytokine secretion 0.023437 LYN, ABCA1, LCP2 481 7 13528 12.05346 1 0.114653 35.55531
GO:0006978~DNA damage response, 0.023437 HIPK2, BRCA2, BRCA1 481 7 13528 12.05346 1 0.114653 35.55531 signal transduction by p53 class mediator resulting in transcription of p21 class mediator
GO:0040036~regulation of fibroblast 0.023437 HHIP, NGFR, RUNX2 481 7 13528 12.05346 1 0.114653 35.55531 growth factor receptor signaling pathway
GO:0032091~negative regulation of 0.023437 GTPBP4, NOG, PRKCD 481 7 13528 12.05346 1 0.114653 35.55531 protein binding
GO:0006101~citrate metabolic process 0.023437 STAT5A, STAT5B, GHR 481 7 13528 12.05346 1 0.114653 35.55531
GO:0043496~regulation of protein 0.023437 BCL2, BAX, NRG1 481 7 13528 12.05346 1 0.114653 35.55531 homodimerization activity
GO:0042772~DNA damage response, 0.023437 HIPK2, BRCA2, BRCA1 481 7 13528 12.05346 1 0.114653 35.55531 signal transduction resulting in transcription
GO:0010921~regulation of phosphatase 0.024361 TSC1, SMAD3, JAK2, TGFB2 481 18 13528 6.249942 1 0.118797 36.67526 activity
GO:0042491~auditory receptor cell 0.024361 HES1, MYO6, HES5, GFI1 481 18 13528 6.249942 1 0.118797 36.67526 differentiation
GO:0007492~endoderm development 0.024361 PTHLH, NOTCH1, NKX2-1, TGFB1 481 18 13528 6.249942 1 0.118797 36.67526
GO:0006631~fatty acid metabolic process 0.024386 STAT5A, STAT5B, SNCA, PTGS1, PRKAB1, PPARGC1A, BRCA1, TNFRSF1A, PLA2G4A, MAPK14, 481 198 13528 1.988618 1 0.118766 36.7052
QKI, ALOX5, SYK, GHR
GO:0009746~response to hexose stimulus 0.024835 PRKCQ, TGFBR2, NEUROD1, SMAD2, PTEN, TGFB1 481 47 13528 3.590392 1 0.120693 37.24312
GO:0034284~response to monosaccharide 0.024835 PRKCQ, TGFBR2, NEUROD1, SMAD2, PTEN, TGFB1 481 47 13528 3.590392 1 0.120693 37.24312 stimulus
GO:0006897~endocytosis 0.025331 HRAS, CAV1, MYO6, SNCA, TGFBR2, ABCA1, VAV1, CD36, ARRB2, APOE, IGF2R, TSC2, LRP2, 481 220 13528 1.917596 1 0.122827 37.83178
GHR, HIP1
GO:0010324~membrane invagination 0.025331 HRAS, CAV1, MYO6, SNCA, TGFBR2, ABCA1, VAV1, CD36, ARRB2, APOE, IGF2R, TSC2, LRP2, 481 220 13528 1.917596 1 0.122827 37.83178
GHR, HIP1
GO:0006403~RNA localization 0.025671 XPO1, HHEX, NUP214, TSC1, NXF2, IGF2BP1, QKI, NXF1, NXT2 481 100 13528 2.531227 1 0.124234 38.23191
GO:0048232~male gamete generation 0.026621 BBS4, HTT, LMNA, BRCA2, TBP, KIT, SIRT1, ACVR2A, NOTCH1, HSF1, BAX, MKKS, QKI, 481 308 13528 1.734968 1 0.128425 39.33839
H2AFX, PAFAH1B1, SPATA5, OCA2, XRN2, UTP14C GO:0007283~spermatogenesis 0.026621 BBS4, HTT, LMNA, BRCA2, TBP, KIT, SIRT1, ACVR2A, NOTCH1, HSF1, BAX, MKKS, QKI, 481 308 13528 1.734968 1 0.128425 39.33839
H2AFX, PAFAH1B1, SPATA5, OCA2, XRN2, UTP14C
GO:0006352~transcription initiation 0.02779 TAF4, TAF5, CDK9, TBP, PPARGC1A, MYC, MED1, ERCC2 481 83 13528 2.710818 1 0.133583 40.67428
GO:0034103~regulation of tissue 0.028184 BAX, VEGFA, INPP5D, SPP1 481 19 13528 5.920998 1 0.135204 41.11826 remodeling
GO:0045076~regulation of interleukin-2 0.028184 PRKCQ, STAT5A, STAT5B, FOXP3 481 19 13528 5.920998 1 0.135204 41.11826 biosynthetic process
GO:0050926~regulation of positive 0.028184 VEGFA, SMAD3, FGF10, KDR 481 19 13528 5.920998 1 0.135204 41.11826 chemotaxis
GO:0051966~regulation of synaptic 0.028184 EGFR, PSEN1, DRD2, PRKACA 481 19 13528 5.920998 1 0.135204 41.11826 transmission, glutamatergic
GO:0050927~positive regulation of 0.028184 VEGFA, SMAD3, FGF10, KDR 481 19 13528 5.920998 1 0.135204 41.11826 positive chemotaxis
GO:0006309~DNA fragmentation 0.028184 CDKN2A, BAX, APAF1, MYC 481 19 13528 5.920998 1 0.135204 41.11826 involved in apoptosis
GO:0006304~DNA modification 0.028394 FOS, MLL, DNMT1, MBD4, HELLS 481 33 13528 4.261324 1 0.135985 41.35282
GO:0051928~positive regulation of 0.028394 CAV1, BAX, PLCG2, NKX2-5, F2R 481 33 13528 4.261324 1 0.135985 41.35282 calcium ion transport
GO:0006325~chromatin organization 0.028692 SETDB1, MLL, RBL2, TAF5, CREBBP, RBL1, RB1, MCM2, FOXP3, SIRT1, MEN1, HDAC4, EYA1, 481 378 13528 1.63689 1 0.137164 41.68554
KDM2B, EP300, CHD7, ATXN7, DNMT1, H2AFX, MLL4, HELLS, HDAC6
GO:0034621~cellular macromolecular 0.02983 EIF6, XPO1, CAV1, SMAD4, SMAD3, SMAD2, MCM2, SMAD1, WAS, TTF2, SRC, TGFB1, PTK2, 481 357 13528 1.654396 1 0.142105 42.93862 complex subunit organization PRLR, FBXO5, H2AFX, WASL, NRG1, HELLS, XRN2, HIP1
GO:0002052~positive regulation of 0.030524 DRD2, FOXG1, PAX6 481 8 13528 10.54678 1 0.145032 43.69012 neuroblast proliferation
GO:0030225~macrophage differentiation 0.030524 MMP9, CSF1, CASP8 481 8 13528 10.54678 1 0.145032 43.69012
GO:0030177~positive regulation of Wnt 0.030524 HHEX, SOX4, FGF10 481 8 13528 10.54678 1 0.145032 43.69012 receptor signaling pathway
GO:0032469~endoplasmic reticulum 0.030524 PSEN1, BCL2, BAX 481 8 13528 10.54678 1 0.145032 43.69012 calcium ion homeostasis
GO:0048333~mesodermal cell 0.030524 BMP4, FOXC2, SMAD1 481 8 13528 10.54678 1 0.145032 43.69012 differentiation
GO:0045939~negative regulation of 0.030524 APOE, NFKB1, GFI1 481 8 13528 10.54678 1 0.145032 43.69012 steroid metabolic process
GO:0032332~positive regulation of 0.030524 THRB, RUNX2, GLI3 481 8 13528 10.54678 1 0.145032 43.69012 chondrocyte differentiation
GO:0002902~regulation of B cell 0.030524 BAX, MYC, ADA 481 8 13528 10.54678 1 0.145032 43.69012 apoptosis
GO:0032967~positive regulation of 0.030524 TGFB3, TGFB1, F2R 481 8 13528 10.54678 1 0.145032 43.69012 collagen biosynthetic process
GO:0001710~mesodermal cell fate 0.030524 BMP4, FOXC2, SMAD1 481 8 13528 10.54678 1 0.145032 43.69012 commitment
GO:0045060~negative thymic T cell 0.030524 PTPRC, ZAP70, FAS 481 8 13528 10.54678 1 0.145032 43.69012 selection
GO:0010894~negative regulation of 0.030524 APOE, NFKB1, GFI1 481 8 13528 10.54678 1 0.145032 43.69012 steroid biosynthetic process
GO:0010714~positive regulation of 0.030524 TGFB3, TGFB1, F2R 481 8 13528 10.54678 1 0.145032 43.69012 collagen metabolic process
GO:0030431~sleep 0.030524 FOS, IL18, SNAP25 481 8 13528 10.54678 1 0.145032 43.69012
GO:0051953~negative regulation of amine 0.030524 TNF, PTGS1, SNCA 481 8 13528 10.54678 1 0.145032 43.69012 transport
GO:0032026~response to magnesium ion 0.030524 CCND1, SNCA, PLCG2 481 8 13528 10.54678 1 0.145032 43.69012
GO:0008104~protein localization 0.031185 BID, BBS4, XPO1, CAV1, TNF, DRD2, PPARG, PAX6, TGFB3, FGF10, ABCA1, GLI3, TGFB1, NXT2, 481 882 13528 1.371161 1 0.147795 44.39653 TGFB2, AKT1, NUP214, LSG1, SCG5, FGF2, EGFR, MYO6, LYN, HTT, TP53, MAPK1, CD36, VCP,
PSEN1, ID1, JUN, BAX, FGFR1OP, PSEN2, TSC2, SPTBN1, JAK2, COL1A1, LRP2, LCP2, HDAC6
GO:0034976~response to endoplasmic 0.031306 CCND1, VCP, COL4A3BP, TP53, EIF2AK3 481 34 13528 4.135991 1 0.148158 44.52587 reticulum stress
GO:0019229~regulation of 0.031306 PRKCQ, CAV1, PTGS1, ALOX5, F2R 481 34 13528 4.135991 1 0.148158 44.52587 vasoconstriction
GO:0002708~positive regulation of 0.031306 MAP3K7, PTPRC, NOD2, STAT5A, STAT5B 481 34 13528 4.135991 1 0.148158 44.52587 lymphocyte mediated immunity
GO:0002705~positive regulation of 0.031306 MAP3K7, PTPRC, NOD2, STAT5A, STAT5B 481 34 13528 4.135991 1 0.148158 44.52587 leukocyte mediated immunity
GO:0006638~neutral lipid metabolic 0.031491 NR1H2, CAV1, APOE, SNCA, SIRT1, LIPE 481 50 13528 3.374969 1 0.148798 44.72138 process
GO:0033261~regulation of S phase 0.032307 CDC7, PTPRC, BRCA2, RB1 481 20 13528 5.624948 1 0.15222 45.57751
GO:0002685~regulation of leukocyte 0.032307 SELP, VEGFA, ADAM17, ADA 481 20 13528 5.624948 1 0.15222 45.57751 migration
GO:0031330~negative regulation of 0.032307 AKT1, HDAC4, INS, IGF2, MTOR 481 20 13528 5.624948 1 0.15222 45.57751 cellular catabolic process
GO:0042312~regulation of vasodilation 0.032307 CAV1, NOS1, INS, NOS3, IGF2 481 20 13528 5.624948 1 0.15222 45.57751
GO:0030890~positive regulation of B cell 0.032307 PTPRC, CDKN1A, IL13, ADA 481 20 13528 5.624948 1 0.15222 45.57751 proliferation
GO:0019048~virus-host interaction 0.032307 HIPK2, SMAD3, INSR, TGFB1 481 20 13528 5.624948 1 0.15222 45.57751
GO:0032651~regulation of interleukin-1 0.032307 NOD2, SMAD3, JAK2, F2R 481 20 13528 5.624948 1 0.15222 45.57751 beta production
GO:0002443~leukocyte mediated 0.032896 NBN, NOD2, MYD88, LYN, ADAM17, FAS, INPP5D, PRKCD 481 86 13528 2.616255 1 0.154632 46.18876 immunity
GO:0050877~neurological system process 0.033073 HRAS, NBN, SLC6A3, SNCA, PAX6, PAX3, PAX2, PTEN, TGFB1, FOS, BDNF, WDR36, APOE, ILK, 481 1210 13528 1.301641 1 0.155224 46.37089 MKKS, QKI, MYC, FGF2, EGR1, MYO6, EGR2, CCKBR, ESR2, MAPK1, EYA1, PSEN1, CAMK4,
ARRB2, JUN, PSEN2, COL1A1, FBXO11, BBS4, ACHE, DRD2, ERBB2, COL2A1, KIT, GCH1, EPHB2,
PTK2
GO:0006367~transcription initiation from 0.033237 TAF4, TAF5, CDK9, TBP, PPARGC1A, MED1, ERCC2 481 68 13528 2.895194 1 0.155756 46.53874
RNA polymerase II promoter
GO:0001508~regulation of action 0.033237 EGR2, TSC1, ERBB2, ILK, QKI, TGFB1, ERCC2 481 68 13528 2.895194 1 0.155756 46.53874 potential
GO:0006396~RNA processing 0.033421 RPP38, RNMT, UTP15, PNN, WDR36, CDKN2A, DKC1, QKI, RPP30, IMP4, RBM28, RPP25, TBL3, 481 547 13528 1.491074 1 0.156377 46.72713
SMAD3, SMAD2, HEATR1, SMAD1, PPARGC1A, TTF2, NOLC1, POP1, WDR3, POP4, POP5,
UTP14A, TFB1M, UTP14C, XRN2, POP7
GO:0060041~retina development in 0.034388 BMP4, CHD7, BAX, BMPR1B, APC 481 35 13528 4.01782 1 0.160402 47.70605 camera-type eye
GO:0060191~regulation of lipase activity 0.034729 NR1H2, EGFR, EDNRB, CCKBR, DRD2, PTH1R, JAK2, F2R 481 87 13528 2.586183 1 0.16169 48.04651
GO:0051656~establishment of organelle 0.035357 BBS4, PTK2, PSEN1, MKKS, PAFAH1B1, BIRC5, CDCA5 481 69 13528 2.853235 1 0.164217 48.66944 localization
GO:0000226~microtubule cytoskeleton 0.03661 BBS4, CAV1, RANBP9, RET, PTK2, FGFR1OP, BRCA2, FBXO5, PAFAH1B1, BRCA1, RANBP10 481 147 13528 2.104572 1 0.169416 49.89096 organization
GO:0001754~eye photoreceptor cell 0.036725 BBS4, VEGFA, PAX6, STAT3 481 21 13528 5.357093 1 0.169712 50.00165 differentiation
GO:0030514~negative regulation of BMP 0.036725 CAV1, NOG, HIPK2, CHRD 481 21 13528 5.357093 1 0.169712 50.00165 signaling pathway
GO:0048599~oocyte development 0.036725 BCL2, BRCA2, FBXO5, AXIN1 481 21 13528 5.357093 1 0.169712 50.00165
GO:0032675~regulation of interleukin-6 0.03764 NOD2, CEBPB, TNF, TLR4, INPP5D 481 36 13528 3.906214 1 0.173423 50.87425 production
GO:0043407~negative regulation of MAP 0.03764 CAV1, APOE, TSC2, PDCD4, TP73 481 36 13528 3.906214 1 0.173423 50.87425 kinase activity GO:0045911~positive regulation of DNA 0.038337 STAT6, PTPRC, TGFB1 481 9 13528 9.374913 1 0.176187 51.52926 recombination
GO:0052200~response to host defenses 0.038337 SMAD3, TLR4, TGFB1 481 9 13528 9.374913 1 0.176187 51.52926
GO:0043368~positive T cell selection 0.038337 PTPRC, BCL2, ZAP70 481 9 13528 9.374913 1 0.176187 51.52926
GO:0021940~positive regulation of 0.038337 IGF1, GLI2, FGF2 481 9 13528 9.374913 1 0.176187 51.52926 granule cell precursor proliferation
GO:0048635~negative regulation of 0.038337 BMP4, LEF1, NGFR 481 9 13528 9.374913 1 0.176187 51.52926 muscle development
GO:0043536~positive regulation of blood 0.038337 VEGFA, FGF2, TGFB1 481 9 13528 9.374913 1 0.176187 51.52926 vessel endothelial cell migration
GO:0043383~negative T cell selection 0.038337 PTPRC, ZAP70, FAS 481 9 13528 9.374913 1 0.176187 51.52926
GO:0043537~negative regulation of blood 0.038337 APOE, FGF2, TGFB1 481 9 13528 9.374913 1 0.176187 51.52926 vessel endothelial cell migration
GO:0045830~positive regulation of 0.038337 STAT6, PTPRC, TGFB1 481 9 13528 9.374913 1 0.176187 51.52926 isotype switching
GO:0051145~smooth muscle cell 0.038337 BMP4, FGF10, ACVR1 481 9 13528 9.374913 1 0.176187 51.52926 differentiation
GO:0002040~sprouting angiogenesis 0.038337 NOTCH1, SRF, FGF2 481 9 13528 9.374913 1 0.176187 51.52926
GO:0048260~positive regulation of 0.038337 CBL, FGF10, HIP1 481 9 13528 9.374913 1 0.176187 51.52926 receptor-mediated endocytosis
GO:0052173~response to defenses of 0.038337 SMAD3, TLR4, TGFB1 481 9 13528 9.374913 1 0.176187 51.52926 other organism during symbiotic interaction
GO:0021936~regulation of granule cell 0.038337 IGF1, GLI2, FGF2 481 9 13528 9.374913 1 0.176187 51.52926 precursor proliferation
GO:0006599~phosphagen metabolic 0.038337 STAT5A, STAT5B, GHR 481 9 13528 9.374913 1 0.176187 51.52926 process
GO:0006600~creatine metabolic process 0.038337 STAT5A, STAT5B, GHR 481 9 13528 9.374913 1 0.176187 51.52926
GO:0006105~succinate metabolic process 0.038337 STAT5A, STAT5B, GHR 481 9 13528 9.374913 1 0.176187 51.52926
GO:0021984~adenohypophysis 0.038337 EYA1, DRD2, SLC6A3 481 9 13528 9.374913 1 0.176187 51.52926 development
GO:0010869~regulation of receptor 0.038337 PPARG, ITGB3, HDAC6 481 9 13528 9.374913 1 0.176187 51.52926 biosynthetic process
GO:0075136~response to host 0.038337 SMAD3, TLR4, TGFB1 481 9 13528 9.374913 1 0.176187 51.52926
GO:0043491~protein kinase B signaling 0.038337 AKT1, TSC2, IRS1 481 9 13528 9.374913 1 0.176187 51.52926 cascade
GO:0032874~positive regulation of 0.038337 NOD2, TLR4, TGFB2 481 9 13528 9.374913 1 0.176187 51.52926 stress-activated MAPK cascade
GO:0007160~cell-matrix adhesion 0.038593 PDPK1, TSC1, CD44, CTGF, BCL2, ILK, ITGB4, ITGB3 481 89 13528 2.528067 1 0.17707 51.76788
GO:0030162~regulation of proteolysis 0.039166 AKT1, TNF, EP300, INS, APOE, IGF2, HDAC6 481 53 13528 3.183933 1 0.179288 52.29738
GO:0016032~viral reproduction 0.039853 XRCC5, CXCR4, HIPK2, SMAD3, GFI1, INSR, TGFB1 481 71 13528 2.772862 1 0.181978 52.9255
GO:0031214~biomineral formation 0.041063 PTH1R, COL1A1, EIF2AK3, SPP1, ERCC2 481 37 13528 3.800641 1 0.18684 54.01197
GO:0009895~negative regulation of 0.041063 AKT1, HDAC4, TNF, INS, IGF2, MTOR 481 37 13528 3.800641 1 0.18684 54.01197 catabolic process
GO:0019722~calcium-mediated signaling 0.041063 EGFR, TNF, SPHK1, EIF2AK3, BTK 481 37 13528 3.800641 1 0.18684 54.01197
GO:0006476~protein amino acid 0.041437 HDAC4, SIRT6, SIRT1, HDAC6 481 22 13528 5.113589 1 0.188188 54.34298 deacetylation
GO:0007628~adult walking behavior 0.041437 CHD7, HTRA2, DRD2, HIPK2 481 22 13528 5.113589 1 0.188188 54.34298
GO:0009994~oocyte differentiation 0.041437 BCL2, BRCA2, FBXO5, AXIN1 481 22 13528 5.113589 1 0.188188 54.34298
GO:0045088~regulation of innate immune 0.041956 NOD2, MYD88, INS, STAT5A, STAT5B, IGF2, TLR4 481 54 13528 3.124971 1 0.190137 54.79916 response
GO:0015833~peptide transport 0.041956 HTT, NEUROD1, SMAD2, ABCA1, EIF2AK3, SNAP25 481 54 13528 3.124971 1 0.190137 54.79916 GO:0048477~oogenesis 0.044656 BCL2, BRCA2, FBXO5, BMPR1B, AXIN1 481 38 13528 3.700624 1 0.201077 57.10156
GO:0051640~organelle localization 0.044902 BBS4, PTK2, PSEN1, MKKS, PAFAH1B1, BIRC5, CDCA5, HDAC6 481 92 13528 2.44563 1 0.201859 57.30553
GO:0006921~cell structure disassembly 0.046436 CDKN2A, BAX, APAF1, MYC 481 23 13528 4.891259 1 0.207899 58.55858 during apoptosis
GO:0032652~regulation of interleukin-1 0.046436 NOD2, SMAD3, JAK2, F2R 481 23 13528 4.891259 1 0.207899 58.55858 production
GO:0042531~positive regulation of 0.046436 LYN, IGF1, JAK2, GHR 481 23 13528 4.891259 1 0.207899 58.55858 tyrosine phosphorylation of STAT protein
GO:0006103~2-oxoglutarate metabolic 0.046816 STAT5A, STAT5B, GHR 481 10 13528 8.437422 1 0.209213 58.86372 process
GO:0021513~spinal cord dorsal/ventral 0.046816 GLI2, GLI3, CHRD 481 10 13528 8.437422 1 0.209213 58.86372 patterning
GO:0030858~positive regulation of 0.046816 NOTCH1, PAX6, APC 481 10 13528 8.437422 1 0.209213 58.86372 epithelial cell differentiation
GO:0014074~response to purine 0.046816 CCNE1, BCL2, PPARG 481 10 13528 8.437422 1 0.209213 58.86372
GO:0032872~regulation of stress-activated 0.046816 NOD2, TLR4, TGFB2 481 10 13528 8.437422 1 0.209213 58.86372
MAPK cascade
GO:0006107~oxaloacetate metabolic 0.046816 STAT5A, STAT5B, GHR 481 10 13528 8.437422 1 0.209213 58.86372 process
GO:0030325~adrenal gland development 0.046816 PBX1, CITED2, NR5A1 481 10 13528 8.437422 1 0.209213 58.86372
GO:0032891~negative regulation of 0.046816 AKT1, TNF, AKT2 481 10 13528 8.437422 1 0.209213 58.86372 organic acid transport
GO:0033151~V(D)J recombination 0.046816 RAG1, PRKDC, RAG2 481 10 13528 8.437422 1 0.209213 58.86372
GO:0031103~axon regeneration 0.046816 BCL2, RXRA, JAK2 481 10 13528 8.437422 1 0.209213 58.86372
GO:0043403~skeletal muscle regeneration 0.046816 PAX7, IGF1, PLAU 481 10 13528 8.437422 1 0.209213 58.86372
GO:0051149~positive regulation of 0.046816 BCL2, ILK, NRG1 481 10 13528 8.437422 1 0.209213 58.86372 muscle cell differentiation
GO:0042523~positive regulation of 0.046816 IGF1, JAK2, GHR 481 10 13528 8.437422 1 0.209213 58.86372 tyrosine phosphorylation of Stat5 protein
GO:0042953~lipoprotein transport 0.046816 CD36, PPARG, LRP2 481 10 13528 8.437422 1 0.209213 58.86372
GO:0060134~prepulse inhibition 0.046816 DRD2, SLC6A3, GRIN1 481 10 13528 8.437422 1 0.209213 58.86372
GO:0006878~cellular copper ion 0.046816 ATP7A, MT2A, PRNP 481 10 13528 8.437422 1 0.209213 58.86372 homeostasis
GO:0042088~T-helper 1 type immune 0.046816 IL18, VEGFA, TLR4 481 10 13528 8.437422 1 0.209213 58.86372 response
GO:0045687~positive regulation of glial 0.046816 NOTCH1, BMP2, PPARG 481 10 13528 8.437422 1 0.209213 58.86372 cell differentiation
GO:0016458~gene silencing 0.047887 SMAD3, SIRT6, SMAD2, SMAD1, SIRT1, HELLS 481 56 13528 3.013365 1 0.213315 59.71151
GO:0019724~B cell mediated immunity 0.047887 NBN, NOD2, MYD88, FAS, INPP5D, PRKCD 481 56 13528 3.013365 1 0.213315 59.71151
GO:0007613~memory 0.048419 PSEN1, PSEN2, GRIN1, SNAP25, PTEN 481 39 13528 3.605736 1 0.215222 60.12649
GO:0060326~cell chemotaxis 0.048419 EDNRB, PDGFRB, ENG, TGFB2, SYK 481 39 13528 3.605736 1 0.215222 60.12649
GO:0014075~response to amine stimulus 0.048419 LYN, DRD2, GRIN1, NOS3, MTOR 481 39 13528 3.605736 1 0.215222 60.12649
GO:0030072~peptide hormone secretion 0.048419 HTT, NEUROD1, SMAD2, EIF2AK3, SNAP25 481 39 13528 3.605736 1 0.215222 60.12649
GO:0060193~positive regulation of lipase 0.049892 NR1H2, EGFR, EDNRB, CCKBR, DRD2, PTH1R, F2R 481 75 13528 2.624976 1 0.220892 61.25448 activity
GO:0048515~spermatid differentiation 0.051029 BBS4, BAX, MKKS, PAFAH1B1, KIT, OCA2 481 57 13528 2.960499 1 0.225181 62.10475
GO:0016444~somatic cell DNA 0.051718 NBN, RAG1, PRKDC, RAG2 481 24 13528 4.687457 1 0.227667 62.61117 recombination
GO:0043487~regulation of RNA stability 0.051718 TNFRSF1B, VEGFA, ELAVL1, IGF2BP1 481 24 13528 4.687457 1 0.227667 62.61117
GO:0002712~regulation of B cell 0.051718 STAT6, PTPRC, NOD2, TGFB1 481 24 13528 4.687457 1 0.227667 62.61117 mediated immunity
GO:0060113~inner ear receptor cell 0.051718 HES1, MYO6, HES5, GFI1 481 24 13528 4.687457 1 0.227667 62.61117 differentiation
GO:0006306~DNA methylation 0.051718 FOS, MLL, DNMT1, HELLS 481 24 13528 4.687457 1 0.227667 62.61117
GO:0006305~DNA alkylation 0.051718 FOS, MLL, DNMT1, HELLS 481 24 13528 4.687457 1 0.227667 62.61117
GO:0002562~somatic diversification of 0.051718 NBN, RAG1, PRKDC, RAG2 481 24 13528 4.687457 1 0.227667 62.61117 immune receptors via germline recombination within a single locus
GO:0002889~regulation of 0.051718 STAT6, PTPRC, NOD2, TGFB1 481 24 13528 4.687457 1 0.227667 62.61117 immunoglobulin mediated immune response
GO:0050796~regulation of insulin 0.052352 GCG, TNF, NEUROD1, JAK2, SNAP25 481 40 13528 3.515593 1 0.229925 63.0716 secretion
GO:0006953~acute-phase response 0.052352 CEBPB, INS, STAT5B, TSC2, IGF2, STAT3 481 40 13528 3.515593 1 0.229925 63.0716
GO:0008033~tRNA processing 0.052623 RPP38, RPP25, POP1, RPP30, POP4, POP5, POP7 481 76 13528 2.590437 1 0.230741 63.26653
GO:0008016~regulation of heart 0.055443 NOS1, THRB, DRD2, JAK2, NKX2-5, ADA, TGFB2 481 77 13528 2.556795 1 0.241528 65.2404 contraction
GO:0045686~negative regulation of glial 0.055904 BMP4, NOG, DLL3 481 11 13528 7.670384 1 0.243058 65.55347 cell differentiation
GO:0045661~regulation of myoblast 0.055904 BMP4, NOTCH1, ILK 481 11 13528 7.670384 1 0.243058 65.55347 differentiation
GO:0021895~cerebral cortex neuron 0.055904 PSEN1, DRD2, NKX2-1 481 11 13528 7.670384 1 0.243058 65.55347 differentiation
GO:0045616~regulation of keratinocyte 0.055904 NOTCH1, TP63, AQP3 481 11 13528 7.670384 1 0.243058 65.55347 differentiation
GO:0080010~regulation of oxygen and 0.055904 AATF, INSR, HDAC6 481 11 13528 7.670384 1 0.243058 65.55347 reactive oxygen species metabolic process
GO:0001782~B cell homeostasis 0.055904 BCL2, BAX, IKBKB 481 11 13528 7.670384 1 0.243058 65.55347 GO:0046686~response to cadmium ion 0.055904 MAPK9, MAPK8, PRNP 481 11 13528 7.670384 1 0.243058 65.55347
GO:0051881~regulation of mitochondrial 0.055904 HTT, BCL2, BAX 481 11 13528 7.670384 1 0.243058 65.55347 membrane potential
GO:0032965~regulation of collagen 0.055904 TGFB3, TGFB1, F2R 481 11 13528 7.670384 1 0.243058 65.55347 biosynthetic process
GO:0014014~negative regulation of 0.055904 BMP4, NOG, DLL3 481 11 13528 7.670384 1 0.243058 65.55347 gliogenesis
GO:0010559~regulation of glycoprotein 0.055904 BCL2, AATF, INSR 481 11 13528 7.670384 1 0.243058 65.55347 biosynthetic process
GO:0031623~receptor internalization 0.055904 ARRB2, SNCA, GHR 481 11 13528 7.670384 1 0.243058 65.55347
GO:0045742~positive regulation of 0.055904 SOS1, ADAM17, TGFA 481 11 13528 7.670384 1 0.243058 65.55347 epidermal growth factor receptor signaling pathway
GO:0002823~negative regulation of 0.055904 STAT6, PTPRC, FOXP3 481 11 13528 7.670384 1 0.243058 65.55347 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0030520~estrogen receptor signaling 0.055904 ESR1, RARA, ESR2 481 11 13528 7.670384 1 0.243058 65.55347 pathway
GO:0043330~response to exogenous 0.055904 MAPK1, NOD2, STAT1 481 11 13528 7.670384 1 0.243058 65.55347 dsRNA
GO:0007379~segment specification 0.055904 HOXA2, MEOX2, MAFB 481 11 13528 7.670384 1 0.243058 65.55347
GO:0043534~blood vessel endothelial cell 0.055904 ID1, SRF, FGF2 481 11 13528 7.670384 1 0.243058 65.55347 migration
GO:0055070~copper ion homeostasis 0.055904 ATP7A, MT2A, PRNP 481 11 13528 7.670384 1 0.243058 65.55347 GO:0042982~amyloid precursor protein 0.055904 ACHE, PSEN1, PSEN2 481 11 13528 7.670384 1 0.243058 65.55347 metabolic process
GO:0007004~telomere maintenance via 0.055904 DKC1, RAD50, TERT 481 11 13528 7.670384 1 0.243058 65.55347 telomerase
GO:0002820~negative regulation of 0.055904 STAT6, PTPRC, FOXP3 481 11 13528 7.670384 1 0.243058 65.55347 adaptive immune response
GO:0030850~prostate gland development 0.055904 NOG, AR, TP63 481 11 13528 7.670384 1 0.243058 65.55347
GO:0008593~regulation of Notch 0.055904 DLL3, TP63, KIT 481 11 13528 7.670384 1 0.243058 65.55347 signaling pathway
GO:0034329~cell junction assembly 0.056454 PDPK1, BCL2, ITGB3, VCL, APC 481 41 13528 3.429846 1 0.244926 65.92324
GO:0050657~nucleic acid transport 0.056815 XPO1, HHEX, NUP214, TSC1, NXF2, QKI, NXF1, NXT2 481 97 13528 2.319566 1 0.246056 66.1638
GO:0050658~RNA transport 0.056815 XPO1, HHEX, NUP214, TSC1, NXF2, QKI, NXF1, NXT2 481 97 13528 2.319566 1 0.246056 66.1638
GO:0051236~establishment of RNA 0.056815 XPO1, HHEX, NUP214, TSC1, NXF2, QKI, NXF1, NXT2 481 97 13528 2.319566 1 0.246056 66.1638 localization
GO:0032273~positive regulation of 0.057277 CAV1, CDKN1B, MTOR, APC 481 25 13528 4.499958 1 0.247572 66.46959 protein polymerization
GO:0046530~photoreceptor cell 0.057277 BBS4, VEGFA, PAX6, STAT3 481 25 13528 4.499958 1 0.247572 66.46959 differentiation
GO:0021515~cell differentiation in spinal 0.057277 PAX7, PAX3, GLI2, GLI3 481 25 13528 4.499958 1 0.247572 66.46959 cord
GO:0010594~regulation of endothelial cell 0.057277 APOE, VEGFA, FGF2, TGFB1 481 25 13528 4.499958 1 0.247572 66.46959 migration
GO:0045862~positive regulation of 0.057277 AKT1, TNF, EP300, APOE 481 25 13528 4.499958 1 0.247572 66.46959 proteolysis
GO:0002526~acute inflammatory response 0.059411 CEBPB, LYN, INS, STAT5B, TSC2, IGF2, TLR4, STAT3, ACVR1 481 98 13528 2.295897 1 0.255479 67.84843
GO:0031589~cell-substrate adhesion 0.059411 PDPK1, TSC1, CD44, CTGF, BCL2, ILK, ITGB4, ITGB3 481 98 13528 2.295897 1 0.255479 67.84843 GO:0050868~negative regulation of T cell 0.060724 CDKN2A, IL2RA, ERBB2, FOXP3, TGFB1 481 42 13528 3.348183 1 0.260193 68.66944 activation
GO:0034622~cellular macromolecular 0.061807 EIF6, XPO1, CAV1, SMAD4, SMAD3, SMAD2, MCM2, SMAD1, WAS, SRC, TGFB1, PTK2, PRLR, 481 318 13528 1.591966 1 0.26401 69.33215 complex assembly FBXO5, H2AFX, NRG1, HELLS, HIP1
GO:0022898~regulation of transmembrane 0.063106 INS, DRD2, PLCG2, IGF2, NKX2-5 481 26 13528 4.326883 1 0.268609 70.10916 transporter activity
GO:0021782~glial cell development 0.063106 EGFR, LYN, SOX11, ERCC2 481 26 13528 4.326883 1 0.268609 70.10916
GO:0050878~regulation of body fluid 0.063744 CD36, FLI1, THBD, FOXA2, DRD2, ITGB3, WAS, PLAU, TP73, F2R 481 141 13528 1.994662 1 0.270714 70.48437 levels
GO:0008217~regulation of blood pressure 0.06482 EDNRB, DRD2, PTGS1, PPARG, NKX2-1, NOS3, ENG, GCH1 481 100 13528 2.249979 1 0.274435 71.10641
GO:0051899~membrane depolarization 0.06516 CAV1, JUN, BCL2, SNCA, GRIN1 481 43 13528 3.270319 1 0.275407 71.29999
GO:0006641~triglyceride metabolic 0.06516 NR1H2, CAV1, APOE, SIRT1, LIPE 481 43 13528 3.270319 1 0.275407 71.29999 process
GO:0034599~cellular response to 0.06516 ATP7A, FOS, SNCA, ARNT, HDAC6 481 43 13528 3.270319 1 0.275407 71.29999 oxidative stress
GO:0032940~secretion by cell 0.065422 MYO6, LYN, HTT, SMAD2, ABCA1, BDNF, PSEN1, NEUROD1, LRP2, SNAP25, EIF2AK3, SYK, 481 207 13528 1.766288 1 0.276093 71.44916
LCP2
GO:0045909~positive regulation of 0.065548 NOS1, INS, NOS3, IGF2 481 12 13528 7.031185 1 0.276269 71.51995 vasodilation
GO:0046688~response to copper ion 0.065548 ATP7A, BCL2, PRNP 481 12 13528 7.031185 1 0.276269 71.51995
GO:0031116~positive regulation of 0.065548 CAV1, CDKN1B, APC 481 12 13528 7.031185 1 0.276269 71.51995 microtubule polymerization
GO:0048814~regulation of dendrite 0.065548 ILK, GRIN1, SMAD1 481 12 13528 7.031185 1 0.276269 71.51995 morphogenesis
GO:0048048~embryonic eye 0.065548 RARG, RARB, ZEB1 481 12 13528 7.031185 1 0.276269 71.51995 morphogenesis GO:0007029~endoplasmic reticulum 0.065548 HTT, COL4A3BP, EIF2AK3 481 12 13528 7.031185 1 0.276269 71.51995 organization
GO:0010833~telomere maintenance via 0.065548 DKC1, RAD50, TERT 481 12 13528 7.031185 1 0.276269 71.51995 telomere lengthening
GO:0021952~central nervous system 0.065548 PAFAH1B1, GLI2, EPHB2 481 12 13528 7.031185 1 0.276269 71.51995 projection neuron axonogenesis
GO:0014910~regulation of smooth muscle 0.065548 BCL2, ILK, IGF1 481 12 13528 7.031185 1 0.276269 71.51995 cell migration
GO:0000768~syncytium formation by 0.065548 NOS1, CD44, CAPN2 481 12 13528 7.031185 1 0.276269 71.51995 plasma membrane fusion
GO:0035196~gene silencing by miRNA, 0.065548 SMAD3, SMAD2, SMAD1 481 12 13528 7.031185 1 0.276269 71.51995 production of miRNAs
GO:0010712~regulation of collagen 0.065548 TGFB3, TGFB1, F2R 481 12 13528 7.031185 1 0.276269 71.51995 metabolic process
GO:0031102~neuron projection 0.065548 BCL2, RXRA, JAK2 481 12 13528 7.031185 1 0.276269 71.51995 regeneration
GO:0010259~multicellular organismal 0.065548 HTT, TP63, INPP5D 481 12 13528 7.031185 1 0.276269 71.51995 aging
GO:0007059~chromosome segregation 0.067621 PDS5B, NIPBL, PSEN1, BIRC5, CDCA5, TOP2A, BRCA1 481 81 13528 2.430533 1 0.283602 72.66818
GO:0022415~viral reproductive process 0.068508 XRCC5, CXCR4, HIPK2, SMAD3, INSR, TGFB1 481 62 13528 2.721749 1 0.286548 73.14583
GO:0046903~secretion 0.068996 MYO6, LYN, DRD2, HTT, SMAD2, ABCA1, AQP1, TP73, AQP3, BDNF, PSEN1, NEUROD1, LRP2, 481 300 13528 1.593735 1 0.288027 73.40512
SNAP25, EIF2AK3, SYK, LCP2
GO:0060415~muscle tissue 0.069197 RXRA, FOXC2, FOXC1, NKX2-5 481 27 13528 4.166628 1 0.288463 73.51158 morphogenesis
GO:0042098~T cell proliferation 0.069197 PTPRC, CXCR4, BAX, TP53 481 27 13528 4.166628 1 0.288463 73.51158
GO:0006284~base-excision repair 0.069197 POLG, TP53, MBD4, APEX1 481 27 13528 4.166628 1 0.288463 73.51158 GO:0045732~positive regulation of 0.069197 AKT1, TNF, APOE, APC 481 27 13528 4.166628 1 0.288463 73.51158 protein catabolic process
GO:0034762~regulation of transmembrane 0.069197 INS, DRD2, PLCG2, IGF2, NKX2-5 481 27 13528 4.166628 1 0.288463 73.51158 transport
GO:0030073~insulin secretion 0.069197 HTT, NEUROD1, SMAD2, EIF2AK3 481 27 13528 4.166628 1 0.288463 73.51158
GO:0055008~cardiac muscle tissue 0.069197 RXRA, FOXC2, FOXC1, NKX2-5 481 27 13528 4.166628 1 0.288463 73.51158 morphogenesis
GO:0002200~somatic diversification of 0.069197 NBN, RAG1, PRKDC, RAG2 481 27 13528 4.166628 1 0.288463 73.51158 immune receptors
GO:0070483~detection of hypoxia 0.069707 TGFB3, ENG 481 2 13528 28.12474 1 0.290015 73.77927
GO:0021776~smoothened signaling 0.069707 GLI2, GLI3 481 2 13528 28.12474 1 0.290015 73.77927 pathway involved in spinal cord motor neuron cell fate specification
GO:0060363~cranial suture 0.069707 TGFB3, TGFB1 481 2 13528 28.12474 1 0.290015 73.77927 morphogenesis
GO:0043366~beta selection 0.069707 ZAP70, SYK 481 2 13528 28.12474 1 0.290015 73.77927
GO:0046666~retinal cell programmed cell 0.069707 BAX, FASLG 481 2 13528 28.12474 1 0.290015 73.77927 death
GO:0033087~negative regulation of 0.069707 CDKN2A, ERBB2 481 2 13528 28.12474 1 0.290015 73.77927 immature T cell proliferation
GO:0060272~embryonic skeletal joint 0.069707 NOG, COL2A1 481 2 13528 28.12474 1 0.290015 73.77927 morphogenesis
GO:0051834~evasion or tolerance of 0.069707 SMAD3, TGFB1 481 2 13528 28.12474 1 0.290015 73.77927 defenses of other organism during symbiotic interaction
GO:0043932~ossification involved in 0.069707 TGFB3, TGFB1 481 2 13528 28.12474 1 0.290015 73.77927 bone remodeling
GO:0051832~avoidance of defenses of 0.069707 SMAD3, TGFB1 481 2 13528 28.12474 1 0.290015 73.77927 other organism during symbiotic interaction
GO:0033084~regulation of immature T 0.069707 CDKN2A, ERBB2 481 2 13528 28.12474 1 0.290015 73.77927 cell proliferation in the thymus
GO:0021754~facial nucleus development 0.069707 HOXA1, HOXB1 481 2 13528 28.12474 1 0.290015 73.77927
GO:0021658~rhombomere 3 0.069707 HOXA2, EGR2 481 2 13528 28.12474 1 0.290015 73.77927 morphogenesis
GO:0010735~positive regulation of 0.069707 SRF, NKX2-5 481 2 13528 28.12474 1 0.290015 73.77927 transcription via serum response element binding
GO:0021775~smoothened signaling 0.069707 GLI2, GLI3 481 2 13528 28.12474 1 0.290015 73.77927 pathway involved in ventral spinal cord interneuron specification
GO:0019049~evasion of host defenses by 0.069707 SMAD3, TGFB1 481 2 13528 28.12474 1 0.290015 73.77927 virus
GO:0010957~negative regulation of 0.069707 NFKB1, GFI1 481 2 13528 28.12474 1 0.290015 73.77927 vitamin D biosynthetic process
GO:0042488~positive regulation of 0.069707 CSF1, NGFR 481 2 13528 28.12474 1 0.290015 73.77927 odontogenesis of dentine-containing tooth
GO:0048102~autophagic cell death 0.069707 CDKN1B, CDKN2D 481 2 13528 28.12474 1 0.290015 73.77927
GO:0051894~positive regulation of focal 0.069707 TSC1, SMAD3 481 2 13528 28.12474 1 0.290015 73.77927 adhesion formation
GO:0060364~frontal suture 0.069707 TGFB3, TGFB1 481 2 13528 28.12474 1 0.290015 73.77927 morphogenesis GO:0033025~regulation of mast cell 0.069707 STAT5A, ADAM17 481 2 13528 28.12474 1 0.290015 73.77927 apoptosis
GO:0007497~posterior midgut 0.069707 EDNRB, RET 481 2 13528 28.12474 1 0.290015 73.77927 development
GO:0009814~defense response, 0.069707 TNFRSF1A, TGFB1 481 2 13528 28.12474 1 0.290015 73.77927 incompatible interaction
GO:0021593~rhombomere morphogenesis 0.069707 HOXA2, EGR2 481 2 13528 28.12474 1 0.290015 73.77927
GO:0042482~positive regulation of 0.069707 CSF1, NGFR 481 2 13528 28.12474 1 0.290015 73.77927 odontogenesis
GO:0042977~activation of JAK2 kinase 0.069707 PRLR, GHR 481 2 13528 28.12474 1 0.290015 73.77927 activity
GO:0033088~negative regulation of 0.069707 CDKN2A, ERBB2 481 2 13528 28.12474 1 0.290015 73.77927 immature T cell proliferation in the thymus
GO:0021568~rhombomere 2 development 0.069707 HOXA2, GBX2 481 2 13528 28.12474 1 0.290015 73.77927
GO:0044413~avoidance of host defenses 0.069707 SMAD3, TGFB1 481 2 13528 28.12474 1 0.290015 73.77927
GO:0032660~regulation of interleukin-17 0.069707 NOD2, TGFB1 481 2 13528 28.12474 1 0.290015 73.77927 production
GO:0002358~B cell homeostatic 0.069707 BAX, RAG2 481 2 13528 28.12474 1 0.290015 73.77927 proliferation
GO:0033197~response to vitamin E 0.069707 CCNE1, CCND1 481 2 13528 28.12474 1 0.290015 73.77927
GO:0051097~negative regulation of 0.069707 TP53, SIRT1 481 2 13528 28.12474 1 0.290015 73.77927 helicase activity
GO:0046137~negative regulation of 0.069707 NFKB1, GFI1 481 2 13528 28.12474 1 0.290015 73.77927 vitamin metabolic process
GO:0060027~convergent extension 0.069707 BBS4, MKKS 481 2 13528 28.12474 1 0.290015 73.77927 involved in gastrulation
GO:0044415~evasion or tolerance of host 0.069707 SMAD3, TGFB1 481 2 13528 28.12474 1 0.290015 73.77927 defenses
GO:0035066~positive regulation of 0.069707 FOXP3, PPARGC1A 481 2 13528 28.12474 1 0.290015 73.77927 histone acetylation
GO:0060026~convergent extension 0.069707 BBS4, MKKS 481 2 13528 28.12474 1 0.290015 73.77927
GO:0000189~nuclear translocation of 0.069707 MAPK1, FGF2 481 2 13528 28.12474 1 0.290015 73.77927
MAPK
GO:0021990~neural plate formation 0.069707 HTT, GLI2 481 2 13528 28.12474 1 0.290015 73.77927
GO:0046544~development of secondary 0.069707 STAT5A, STAT5B 481 2 13528 28.12474 1 0.290015 73.77927 male sexual characteristics
GO:0032740~positive regulation of 0.069707 NOD2, TGFB1 481 2 13528 28.12474 1 0.290015 73.77927 interleukin-17 production
GO:0010639~negative regulation of 0.07089 SNCA, DNMT1, SPTBN1, FOXP3, BRCA1, HDAC6, APC 481 82 13528 2.400892 1 0.293984 74.38993 organelle organization
GO:0050821~protein stabilization 0.075544 GTPBP4, SOX4, PPARGC1A, PRKCD 481 28 13528 4.01782 1 0.310258 76.6648
GO:0007159~leukocyte adhesion 0.075544 SELP, PTPRC, TNF, SYK 481 28 13528 4.01782 1 0.310258 76.6648
GO:0045061~thymic T cell selection 0.075696 PTPRC, ZAP70, FAS 481 13 13528 6.490325 1 0.310482 76.73582
GO:0033198~response to ATP 0.075696 SELL, PLCG2, PTEN 481 13 13528 6.490325 1 0.310482 76.73582
GO:0021879~forebrain neuron 0.075696 ATP7A, PAX6, NKX2-1 481 13 13528 6.490325 1 0.310482 76.73582 differentiation
GO:0034612~response to tumor necrosis 0.075696 CASP8, INSR, GCH1 481 13 13528 6.490325 1 0.310482 76.73582 factor
GO:0042993~positive regulation of 0.075696 PRKCQ, TNF, SMAD3 481 13 13528 6.490325 1 0.310482 76.73582 transcription factor import into nucleus
GO:0010595~positive regulation of 0.075696 VEGFA, FGF2, TGFB1 481 13 13528 6.490325 1 0.310482 76.73582 endothelial cell migration
GO:0050995~negative regulation of lipid 0.075696 AKT1, TNF, INS, IGF2 481 13 13528 6.490325 1 0.310482 76.73582 catabolic process
GO:0031112~positive regulation of 0.075696 CAV1, CDKN1B, APC 481 13 13528 6.490325 1 0.310482 76.73582 microtubule polymerization or depolymerization
GO:0031050~dsRNA fragmentation 0.075696 SMAD3, SMAD2, SMAD1 481 13 13528 6.490325 1 0.310482 76.73582
GO:0045730~respiratory burst 0.075696 PRKCQ, CYBB, INS, IGF2 481 13 13528 6.490325 1 0.310482 76.73582
GO:0050820~positive regulation of 0.075696 PSEN1, PSEN2, F2R 481 13 13528 6.490325 1 0.310482 76.73582 coagulation
GO:0045086~positive regulation of 0.075696 PRKCQ, STAT5A, STAT5B 481 13 13528 6.490325 1 0.310482 76.73582 interleukin-2 biosynthetic process
GO:0045191~regulation of isotype 0.075696 STAT6, PTPRC, TGFB1 481 13 13528 6.490325 1 0.310482 76.73582 switching
GO:0044253~positive regulation of 0.075696 TGFB3, TGFB1, F2R 481 13 13528 6.490325 1 0.310482 76.73582 multicellular organismal metabolic process
GO:0031113~regulation of microtubule 0.075696 CAV1, CDKN1B, APC 481 13 13528 6.490325 1 0.310482 76.73582 polymerization
GO:0051235~maintenance of location 0.076319 BBS4, CAV1, TNF, APOE, FGFR1OP, NR5A1 481 64 13528 2.636694 1 0.312362 77.02467
GO:0045089~positive regulation of innate 0.079445 NOD2, MYD88, STAT5A, STAT5B, TLR4 481 46 13528 3.057037 1 0.32295 78.42312 immune response
GO:0007623~circadian rhythm 0.079445 EGFR, ERBB3, DRD2, JUN, ADA 481 46 13528 3.057037 1 0.32295 78.42312
GO:0016569~covalent chromatin 0.079535 MEN1, HDAC4, EYA1, EP300, ATXN7, CREBBP, SIRT1, HELLS, HDAC6 481 126 13528 2.00891 1 0.322942 78.46215 modification
GO:0007202~activation of phospholipase 0.080397 EGFR, EDNRB, CCKBR, DRD2, PTH1R, F2R 481 65 13528 2.59613 1 0.325601 78.83307
C activity GO:0010863~positive regulation of 0.080397 EGFR, EDNRB, CCKBR, DRD2, PTH1R, F2R 481 65 13528 2.59613 1 0.325601 78.83307 phospholipase C activity
GO:0006690~icosanoid metabolic process 0.084525 TNFRSF1A, PLA2G4A, PTGS1, ALOX5, SYK 481 47 13528 2.991994 1 0.339379 80.5255
GO:0006949~syncytium formation 0.0863 NOS1, CD44, CAPN2 481 14 13528 6.02673 1 0.345039 81.21362
GO:0032731~positive regulation of 0.0863 NOD2, SMAD3, JAK2 481 14 13528 6.02673 1 0.345039 81.21362 interleukin-1 beta production
GO:0045069~regulation of viral genome 0.0863 TNF, BCL2, TOP2A 481 14 13528 6.02673 1 0.345039 81.21362 replication
GO:0045604~regulation of epidermal cell 0.0863 NOTCH1, TP63, AQP3 481 14 13528 6.02673 1 0.345039 81.21362 differentiation
GO:0045823~positive regulation of heart 0.0863 NKX2-5, ADA, TGFB2 481 14 13528 6.02673 1 0.345039 81.21362 contraction
GO:0030318~melanocyte differentiation 0.0863 EDNRB, BCL2, OCA2 481 14 13528 6.02673 1 0.345039 81.21362
GO:0010596~negative regulation of 0.0863 APOE, FGF2, TGFB1 481 14 13528 6.02673 1 0.345039 81.21362 endothelial cell migration
GO:0032410~negative regulation of 0.0863 DRD2, SNCA, INSR 481 14 13528 6.02673 1 0.345039 81.21362 transporter activity
GO:0051283~negative regulation of 0.0863 PTPRC, DRD2, F2R 481 14 13528 6.02673 1 0.345039 81.21362 sequestering of calcium ion
GO:0007263~nitric oxide mediated signal 0.0863 CD36, APOE, NEUROD1 481 14 13528 6.02673 1 0.345039 81.21362 transduction
GO:0021795~cerebral cortex cell 0.0863 PSEN1, NKX2-1, PAFAH1B1 481 14 13528 6.02673 1 0.345039 81.21362 migration
GO:0051209~release of sequestered 0.0863 PTPRC, DRD2, F2R 481 14 13528 6.02673 1 0.345039 81.21362 calcium ion into cytosol
GO:0030279~negative regulation of 0.0863 BCL2, SOX9, TGFB1 481 14 13528 6.02673 1 0.345039 81.21362 ossification
GO:0051282~regulation of sequestering of 0.0863 PTPRC, DRD2, F2R 481 14 13528 6.02673 1 0.345039 81.21362 calcium ion
GO:0051028~mRNA transport 0.088571 XPO1, HHEX, NUP214, NXF2, QKI, NXF1, NXT2 481 87 13528 2.26291 1 0.352297 82.06008
GO:0042401~biogenic amine biosynthetic 0.088968 SLC6A3, SNCA, GCH1, TGFB2 481 30 13528 3.749965 1 0.353276 82.20404 process
GO:0007566~embryo implantation 0.088968 PRLR, TGFBR2, PLAU, SPP1 481 30 13528 3.749965 1 0.353276 82.20404
GO:0002824~positive regulation of 0.088968 MAP3K7, PTPRC, NOD2, ADA 481 30 13528 3.749965 1 0.353276 82.20404 adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains
GO:0032649~regulation of 0.088968 NOD2, IL18, RARA, FOXP3 481 30 13528 3.749965 1 0.353276 82.20404 interferon-gamma production
GO:0042990~regulation of transcription 0.088968 PRKCQ, TNF, SMAD3, MBTPS1 481 30 13528 3.749965 1 0.353276 82.20404 factor import into nucleus
GO:0009798~axis specification 0.088968 PAX6, SMAD2, AXIN1, APC 481 30 13528 3.749965 1 0.353276 82.20404
GO:0050707~regulation of cytokine 0.088968 NOD2, TNF, INS, IGF2, FOXP3 481 30 13528 3.749965 1 0.353276 82.20404 secretion
GO:0007599~hemostasis 0.089344 CD36, FLI1, THBD, FOXA2, ITGB3, WAS, PLAU, F2R 481 108 13528 2.083314 1 0.354184 82.33966
GO:0051651~maintenance of location in 0.089759 BBS4, CAV1, APOE, FGFR1OP, NR5A1 481 48 13528 2.92966 1 0.355219 82.4883 cell
GO:0006368~RNA elongation from RNA 0.089759 TAF4, TAF5, CDK9, TBP, ERCC2 481 48 13528 2.92966 1 0.355219 82.4883 polymerase II promoter
GO:0050890~cognition 0.091269 BBS4, HRAS, DRD2, SLC6A3, PAX6, COL2A1, PAX3, KIT, PAX2, PTEN, EPHB2, FOS, BDNF, 481 909 13528 1.268553 1 0.359851 83.01865
WDR36, CHD7, MKKS, PAFAH1B1, MYC, SNAP25, AXIN1, EGR1, MYO6, EGR2, CCKBR, HTT, GRIN1, PARK2, ESR2, FOXP2, MAPK1, EYA1, RDH10, CDKN1B, ARRB2, PSEN1, JUN, ATXN7,
PSEN2, COL1A1,
GO:0032271~regulation of protein 0.093313 CAV1, CDKN1B, SPTBN1, MTOR, RASA1, APC 481 68 13528 2.481595 1 0.366187 83.71236 polymerization
GO:0006639~acylglycerol metabolic 0.095146 NR1H2, CAV1, APOE, SIRT1, LIPE 481 49 13528 2.869871 1 0.371781 84.31175 process
GO:0007163~establishment or 0.095146 IGF1R, ILK, PAFAH1B1, APC, DLG1 481 49 13528 2.869871 1 0.371781 84.31175 maintenance of cell polarity
GO:0002821~positive regulation of 0.096028 MAP3K7, PTPRC, NOD2, ADA 481 31 13528 3.628999 1 0.374273 84.59277 adaptive immune response
GO:0031110~regulation of microtubule 0.096028 CAV1, CDKN1B, HDAC6, APC 481 31 13528 3.628999 1 0.374273 84.59277 polymerization or depolymerization
GO:0030808~regulation of nucleotide 0.096192 PTHLH, EDNRB, DRD2, APOE, PTH1R, NOS3, ABCA1, TSHR 481 110 13528 2.045436 1 0.37445 84.64452 biosynthetic process
GO:0030802~regulation of cyclic 0.096192 PTHLH, EDNRB, DRD2, APOE, PTH1R, NOS3, ABCA1, TSHR 481 110 13528 2.045436 1 0.37445 84.64452 nucleotide biosynthetic process
GO:0031290~retinal ganglion cell axon 0.097317 EFNA5, BMPR1B, EPHB2 481 15 13528 5.624948 1 0.377701 84.99469 guidance
GO:0048665~neuron fate specification 0.097317 FOXA2, GLI2, GLI3 481 15 13528 5.624948 1 0.377701 84.99469
GO:0032760~positive regulation of tumor 0.097317 NOD2, MYD88, TLR4 481 15 13528 5.624948 1 0.377701 84.99469 necrosis factor production
GO:0045739~positive regulation of DNA 0.097317 EYA1, H2AFX, BRCA1 481 15 13528 5.624948 1 0.377701 84.99469 repair
GO:0001938~positive regulation of 0.097317 VEGFA, MTOR, ARNT 481 15 13528 5.624948 1 0.377701 84.99469 endothelial cell proliferation
GO:0042402~biogenic amine catabolic 0.097317 ACHE, SLC6A3, DHPS 481 15 13528 5.624948 1 0.377701 84.99469 process
GO:0021872~generation of neurons in the 0.097317 ATP7A, PAX6, NKX2-1 481 15 13528 5.624948 1 0.377701 84.99469 forebrain
GO:0050773~regulation of dendrite 0.097317 ILK, GRIN1, SMAD1 481 15 13528 5.624948 1 0.377701 84.99469 development
GO:0045981~positive regulation of 0.097317 PTHLH, APOE, ABCA1 481 15 13528 5.624948 1 0.377701 84.99469 nucleotide metabolic process
GO:0030804~positive regulation of cyclic 0.097317 PTHLH, APOE, ABCA1 481 15 13528 5.624948 1 0.377701 84.99469 nucleotide biosynthetic process
GO:0051279~regulation of release of 0.097317 LYN, BAX, TGFB1 481 15 13528 5.624948 1 0.377701 84.99469 sequestered calcium ion into cytosol
GO:0045806~negative regulation of 0.097317 NR1H2, PTEN, TGFB1 481 15 13528 5.624948 1 0.377701 84.99469 endocytosis
GO:0014003~oligodendrocyte 0.097317 LYN, SOX11, ERCC2 481 15 13528 5.624948 1 0.377701 84.99469 development
GO:0046627~negative regulation of 0.097317 SOCS1, PRKCD, IRS1 481 15 13528 5.624948 1 0.377701 84.99469 insulin receptor signaling pathway
GO:0050931~pigment cell differentiation 0.097317 EDNRB, BCL2, OCA2 481 15 13528 5.624948 1 0.377701 84.99469
GO:0043489~RNA stabilization 0.097317 VEGFA, ELAVL1, IGF2BP1 481 15 13528 5.624948 1 0.377701 84.99469
GO:0045124~regulation of bone 0.097317 VEGFA, INPP5D, SPP1 481 15 13528 5.624948 1 0.377701 84.99469 resorption
GO:0030810~positive regulation of 0.097317 PTHLH, APOE, ABCA1 481 15 13528 5.624948 1 0.377701 84.99469 nucleotide biosynthetic process
GO:0030801~positive regulation of cyclic 0.097317 PTHLH, APOE, ABCA1 481 15 13528 5.624948 1 0.377701 84.99469 nucleotide metabolic process
GO:0048255~mRNA stabilization 0.097317 VEGFA, ELAVL1, IGF2BP1 481 15 13528 5.624948 1 0.377701 84.99469 GO:0042304~regulation of fatty acid 0.097317 NR1H2, PLA2G4A, BRCA1 481 15 13528 5.624948 1 0.377701 84.99469 biosynthetic process
GO:0046850~regulation of bone 0.097317 VEGFA, INPP5D, SPP1 481 15 13528 5.624948 1 0.377701 84.99469 remodeling
GO:0010518~positive regulation of 0.09784 EGFR, EDNRB, CCKBR, DRD2, PTH1R, F2R 481 69 13528 2.44563 1 0.379018 85.15505 phospholipase activity
GO:0006839~mitochondrial transport 0.09784 BID, PSEN1, HTT, BCL2, BAX, TP53 481 69 13528 2.44563 1 0.379018 85.15505