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DIVISION OF PULMONARY , , AND

Mission The Division of Pulmonary Medicine, Allergy, and Immunology is committed to serving the community through excellence in patient care, teaching, and research. The division provides outstanding comprehensive care to children with acute or chronic pulmonary disorders, allergic diseases, , 293 immune deficiencies, airway lesions, and sleep disorders. The division is dedicated to improving patients’ health through research, including basic science, and translational and clinical investigations related to pulmonary and allergic diseases. Educational goals include teaching patients, their families and caregivers, medical students, residents, fellows, , and other professionals about the , pathophysiology, and treatment of disorders and allergic diseases.

DEPARTMENT OF 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

FACULTY AND STAFF Juan C. Celedón, MD, DrPH Mark Dovey, MD Hiren Muzumdar, MD Niels K. Jerne Professor of Pediatrics Associate Professor of Pediatrics Associate Professor of Pediatrics Professor of , Codirector, Pediatric Sleep Program Epidemiology, and Human Genetics Jonathan D. Finder, MD Division Chief, Pediatric Pulmonary Professor of Pediatrics David R. Nash, MD Medicine, Allergy, and Immunology Director, Outreach Pulmonary Assistant Professor of Pediatrics Director, Pediatric Center, Erick Forno, MD, MPH David M. Orenstein, MD, MA Children’s of Pittsburgh Assistant Professor of Pediatrics Professor of Pediatrics of UPMC Director Emeritus, Antonio J. Todd D. Green, MD John F. Alcorn, PhD and Janet Palumbo Cystic Associate Professor of Pediatrics Associate Professor of Pediatrics Fibrosis Center Program Director, Allergy and Nadia Boutaoui, PhD Immunology Jonathan E. Spahr, MD 294 Assistant Professor of Pediatrics Director, Food Allergy Associate Professor of Pediatrics Laboratory Director Research and Education (FARE) Clinical Director, Pulmonary Medicine Center of Excellence Sangeeta S. Chakravorty, MD Jieru Wang, MD, PhD Associate Professor of Pediatrics Yueh-Ying Han, PhD, MS Assistant Professor of Pediatrics Director, Pediatric Sleep Research Assistant Professor Daniel J. Weiner, MD Evaluation Center in Pediatrics Associate Professor of Pediatrics Wei Chen, PhD Geoffrey Kurland, MD Director, Antonio J. and Janet Associate Professor of Pediatrics, Professor of Pediatrics Palumbo Cystic Fibrosis Center Biostatistics, and Human Genetics Director, Pediatric Flexible Medical Director, Pulmonary Service Function Laboratory Hey Chong, MD, PhD Director, Pediatric Pulmonary Medical Director, Exercise Laboratory Assistant Professor of Pediatrics Transplantation Program Clinical Director, Allergy John Broyles, CRNP and Immunology Allyson Larkin, MD Assistant Professor of Pediatrics Lori Holt, CRNP Program Director, Allergy and Immunology Fellowship

OVERVIEW OF DIVISION

he Division of Pulmonary Medicine, Allergy, and Immunology at the Children’s Hospital of Pittsburgh was ranked fifth in the country in the annual listing prepared byU.S. News & World Report. The division faculty T was pleased to welcome Mark Dovey as an associate professor of pediatrics in March 2017. Hey Chong was appointed clinical director of allergy and immunology in July 2016. Wei Chen was promoted to associate professor of pediatrics, biostatistics, and human genetics in February 2017.

The Pediatric Pulmonary Medicine Fellowship Program trained six fellows during fiscal year 2017 (FY17). In June 2017, Sylvia Szentpetery and Sandeep Puranik graduated from the program. Upon graduation, Szentpetery accepted a position as an assistant professor of pediatrics at the Medical University of South Carolina in Charleston, S.C., and Puranik accepted a position as an assistant professor of pediatrics at the Indiana University School of Medicine in Indianapolis, Ind. In July 2017, two new fellows, Jeremy Landeo and Erica Stevens, began training in the division.

DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

The Allergy and Immunology Fellowship Program trained four fellows during FY17. June 2017 saw the graduations of Shari Montandon and Stacy Rosenberg. Montandon joined a private practice in Coeur d’Alene, Idaho. Rosenberg joined UPMC as a clinical instructor in pediatrics. In July 2017, two new fellows, Leanna-Maire Sims and Kara Coffey, began training in the division.

CLINICAL ACTIVITIES

he division provides comprehensive services to children with a variety of and allergic diseases. The division’s Cystic Fibrosis Center has been honored by the Cystic Fibrosis Foundation as a benchmark center. T The division actively participates in the pediatric lung transplantation program and provides consultative services for patients with asthma, recurrent , bronchopulmonary dysplasia, neuromuscular disorders, airway lesions, food , allergic rhinitis, atopic dermatitis, immune deficiencies, and other respiratory and allergic diseases. Under the direction of Sangeeta Chakravorty and Hiren Muzumdar, the division has developed a comprehensive sleep program for children. The infant pulmonary function laboratory is the only program of its kind in Western Pennsylvania.

RESEARCH AND OTHER SCHOLARLY ACTIVITIES 295 ver the past fiscal year, the division received additional funding from the National Institutes of Health (NIH), including an R01 grant to study the effects of psychosocial stress on response to inhaled in O Puerto Rican children, an R01 to study the mechanisms of secondary Staphylococcus Aureus pneumonia after influenza , and a T32 training grant in pediatric pulmonary medicine. Moreover, the division has added new study sites (at Boston Children’s Hospital and Washington University in Saint Louis) to the ongoing U01-funded clinical trial of vitamin D supplementation to prevent severe asthma exacerbations in children.

Juan C. Celedón, MD, DrPH • Associate editor, American Journal RESEARCH of Respiratory Juan C. Celedón’s research is focused on identifying genetic and Critical Care and epigenetic factors and early-life environmental ex- Medicine posures that influence the pathogenesis of asthma and chronic obstructive pulmonary disease (COPD) in general MAJOR and among ethnic minorities in particular. LECTURESHIPS AND SEMINARS STUDY SECTIONS • “Can We Predict • Board of Scientific Counselors, National Institute of Severe Asthma Environmental Health Sciences Exacerbations?” Congress of the Juan C. Celedón, MD, DrPH ADVISORY COMMITTEE MEMBERSHIPS Latin American Division Chief, Pulmonary Medicine, • Chair, Planning Committee, Environmental and Thoracic Allergy, and Immunology Occupational Health Assembly, American Thoracic Association, Society (ATS) Santiago, Chile, 2016 • Chair, ATS and European Respiratory Society • “Genetics and Epigenetics of Asthma in Latino Workshop/Task Force on Respiratory Health in Americans,” Congress of the Latin American Thoracic Migrant and Refugee Populations Association, Santiago, Chile, 2016 • Elected member (currently secretary-treasurer), • “Genetics and Epigenetics of Stress and Asthma,” Executive Committee, ATS World Allergy Organization international scientific conference, Jerusalem, Israel, 2016 EDITORSHIPS • “Solving the Puzzle of Asthma Disparities,” annual • Editorial Board, American Journal of Respiratory and symposium of the Saban Research Institute of Children’s Critical Care Medicine Hospital of Los Angeles, Los Angeles, Calif., 2017 • Editorial Board,

DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

• “Asthma in Hispanics: An Update,” Partners Asthma • Fellow, American Academy of Allergy, Asthma, grand rounds, Brigham and Women’s Hospital and and Immunology Harvard , Boston, Mass., 2017 • American Society of Human Genetics • “Epigenetics of Asthma,” annual Pneumo Trieste • Federation of American Societies for scientific conference, Trieste, Italy, 2017 Experimental Biology • “COPD in Hispanics,” ATS/European Respiratory Society Workshop on Respiratory Health in Migrant HONORS and Refugee Populations, ATS international conference, • Elected member, American Society for Clinical Inves- Washington, D.C., May 2017 tigation, 2010 to the present • “Genetics and Health Equality,” ATS workshop on • Elected member, American Pediatric Society, 2013 to “High-Throughput Sequencing in Respiratory, Critical the present Care Medicine, and Sleep Research,” ATS international • Elected member, Association of American Physicians, conference, Washington, D.C., May 2017 2015 to the present • “Con: Vitamin D Supplementation Should Be Used in • John M. Peters Award for outstanding contributions 296 Asthma Management,” symposium on “Pro/Con Debate to environmental and population health, ATS in Pediatric Asthma,” ATS international conference, Environmental, Occupational, and Population Health Washington, D.C., May 2017 Assembly, 2017 • Elected to the ATS Executive Committee (first faculty PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS member of the University of Pittsburgh and first • Fellow, American College of Physicians Latino American ever elected to this position since • Fellow, American College of Physicians the inception of ATS in 1905), 2017–2022 • ATS

John F. Alcorn, PhD

RESEARCH MAJOR LECTURESHIPS AND SEMINARS John F. Alcorn studies the role of type 17 immunity in • “Influenza Infection and Susceptibility to Secondary viral and bacterial pneumonia. His studies have focused on Bacterial Pneumonia,” Montana State University, influenza A infection and suppression of type 17 immunity Bozeman, Mont., March 2015 against secondary staphylococcal infection. He has studied • “Influenza Infection and Susceptibility to Secondary the mechanisms of asthma and allergic airway disease, with Bacterial Pneumonia,” University of Georgia, Athens, an emphasis on the role of type 17 cellular immunology. Ga., April 2015 His studies have suggested that disease induced by Th17 • “Th17 Cells in Lung Immunity and Allergy,” ATS cells is steroid resistant and may represent a model for international meeting, Denver, Colo., May 2015 steroid-insensitive asthma. • “Influenza Infection and Susceptibility to Secondary Bacterial Pneumonia,” MedImmune, Gaithersburg, STUDY SECTIONS Md., October 2015 • Immunity and Host Defense Study Section, NIH • Chair, FP-Flu Panel, Department of Defense PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS • P01 Special Emphasis Panel, National Institute of • ATS Allergy and Infectious Diseases, NIH • American Association of Immunologists • F13 Microbiology F Fellowship Study Section, NIH • Immunity and Host Defense Overflow Viral Immunity HONORS • Parker B. Francis Jo Rae Wright Award for Scientific Topics Study Section, NIH Excellence, Parker B. Francis Fellowship Program and EDITORSHIPS the Francis Family Foundation, May 2015 • Associate editor, Journal of Immunology • Elected member, Society for Pediatric Research, • Associate editor, American Journal of Respiratory Cell and 2016 to the present Molecular Biology

DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

Nadia Boutaoui, PhD EDITORSHIPS • Ad hoc reviewer, Nature Genetics RESEARCH • Ad hoc reviewer, Nature Communications Nadia Boutaoui directs the division’s genetics and epigenetics • Ad hoc reviewer, American Journal of Human Genetics laboratory, which studies the impact of heredity and • Ad hoc reviewer, PLOS Genetics environmental exposures in early life on asthma, particularly • Ad hoc reviewer, Bioinformatics in minorities. She trains junior faculty and fellows on genetic • Ad hoc reviewer, BMC Genetics and epigenetic laboratory methods to study asthma. • Ad hoc reviewer, PLOS ONE

PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS • Ad hoc reviewer, BMC • ATS • Ad hoc reviewer, Molecular Vision • American Society of Human Genetics • Ad hoc reviewer, Acta Ophthalmologica • Ad hoc reviewer, Human Heredity • Ad hoc reviewer, Methods Sangeeta S. Chakravorty, MD • Ad hoc reviewer, Briefings in Bioinformatics

RESEARCH • Ad hoc reviewer, BMC Bioinformatics Sangeeta Chakravorty has established a Sleep Disorders • Statistical Advisory Board, PLOS ONE 297 Registry and has enrolled children with sleep disorders from • Guest editor, PLOS Genetics those referred to the pediatric sleep evaluation . She STUDY SECTION has collaborated with Jeffrey Simons and Allison Tobey • Children’s Health Exposure Analysis Resource: Data (otolaryngologist) on INSPIRE, a proposed hypoglossal Repository, Analysis, and Science Center (U2C), nerve stimulator implant in adolescents with trisomy 21. National Institute of Environmental Health Sciences,

PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS Research Triangle Park, N.C. • National Sleep Subcommittee, Autism Treatment PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS Network, 2008 to the present • American Society of Human Genetics • American Academy of , 1999 to the present • American Statistical Association

MAJOR LECTURESHIPS AND SEMINARS • International Biometric Society • “Pharmacological Management of Narcolepsy,” MAJOR LECTURESHIPS AND SEMINARS invited speaker, Annual Respiratory Care Conference, • “Statistical Issues in Genome-Wide Association Studies Cranberry, Pa., September 2016 of Age-Related Macular Degeneration Progression,” • “ 101,” Combined ENT/ Third Taihu International Statistics Forum, Shanghai, Pulmonology Airway Conference, August 2017 China, July 2016

HONORS • “AMD Genetics: Association and Prediction,” annual • Division chief, sleep medicine, Professional Medical meeting of Eastern North American Region Biometric Staff Society, Children’s Hospital of Pittsburgh, June Society, Austin, Texas, March 2016 2017 to the present • “Statistical Issues in Genome-Wide Association Studies of Age-Related Macular Degeneration Progression,” Center for Quantitative Science, Vanderbilt University, Wei Chen, PhD Nashville, Tenn., May 2016 RESEARCH • “The Power of Statistics in Making Sense of Omics Wei Chen’s research focuses on statistical methods and Data,” Department of Pediatrics, analysis for genetic and genomic studies of complex Research Seminar, University of Pittsburgh, Pittsburgh, diseases. He has developed novel methods for genotype Pa., September 2016 calling in next-generation sequencing and has studied • “A Novel Method for Clustering Droplet-Based Single- genetic risk factors for COPD, asthma, and age-related Cell Data,” Recomb-seq, Hong Kong, China, 2017 macular degeneration. In addition, he has studied epigenetics • “DIMMS-SC: Methods for Single-Cell RNA-Seq and its interaction with environment on asthma. He has Data,” Joint Statistical Meeting, Baltimore, Md., 2017 two active R01s from NIH and several collaborative grants from NIH and multiple foundations.

DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

Hey J. Chong, MD, PhD of age with cystic fibrosis, homozygous or heterozygous for the F508delCFTR mutation. RESEARCH

Hey J. Chong is the site principal investigator for two multi- EDITORSHIPS center studies through the Primary Immunodeficiency Treat- • Ad hoc reviewer, (Journal of the American Society ment Consortium. Study 6903 continues looking at patients of ) treated for chronic granulomatous disease with or without • Ad hoc reviewer, American Journal of Respiratory and transplant. Study 6904 continues looking at Wiskott-Aldrich Critical Care Medicine syndrome and the role of transplantation. She is also the site • Ad hoc reviewer, Pediatric Pulmonology principal investigator for six industry-sponsored food-toler- • Ad hoc reviewer, Journal of Pediatrics ance clinical trials through Aimmune and DBV Technologies. • Ad hoc reviewer, American Journal of Perinatology • Ad hoc reviewer, Journal of Developmental and ADVISORY COMMITTEE MEMBERSHIPS Behavioral Pediatrics • Continuing Committee, Clinical Immunology Society, 2014 to the present PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS • Fellowship Research Committee, Children’s Hospital • ATS 298 of Pittsburgh of UPMC HONORS PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS • Top Doctor, U.S. News & World Report, ranked top 1% • Clinical Immunology Society in nation, 2013–2016 • American Academy of Allergy, Asthma, and Immunology • Top Doctor in Pediatric Pulmonology, Boston Magazine, 2015–2016 MAJOR LECTURESHIPS AND SEMINARS • “Primary Immunodeficiency in Your Office” Children’s Hospital of Pittsburgh grand rounds, Pittsburgh, Pa., Jonathan D. Finder, MD September 2017 ADVISORY COMMITTEE MEMBERSHIPS • Panel member, Seventh Annual Update in Allergy and • and Therapeutics Committee, Children’s Sino-Nasal Disorders, University of Pittsburgh School Hospital of Pittsburgh, 2000 to the present of Medicine, Pittsburgh, Pa., May 2017 • Codirector, Medical Staff Campaign, Children’s Hospital • “Primary Immunodeficiency for the Intensivist,” invited of Pittsburgh Foundation, 2001 to the present speaker, grand rounds, Children’s Hospital Intensive • Pharmacy Innovative Use Committee, Children’s Care Unit, Pittsburgh, Pa., November 2016 Hospital of Pittsburgh, 2007 to the present • “How the Clinical Laboratory Helps Identify, Diagnose, • Ambulatory e-Record Optimization Steering Committee, and Manage Patients With Immunodeficiency Diseases,” Children’s Hospital of Pittsburgh, 2011 to the present invited speaker, Association of • Clinical Transformation Steering Committee, Children’s Immunologists meeting, Pittsburgh, Pa., August 2016 Hospital of Pittsburgh, 2014 to the present • “Immunology in Health and Disease,” first-year medical • Task Force 2019, Children’s Hospital of Pittsburgh, course, University of Pittsburgh School of Medicine, April 2016 to the present Pittsburgh, Pa., 2013–2016 EDITORSHIPS • Editorial Advisory Board, RT Magazine, 2004 to the present Mark Dovey, MD

RESEARCH MAJOR LECTURESHIPS AND SEMINARS Mark Dovey is the site principal investigator of two • “Respiratory Management of Patients With multicenter clinical trials of investigational agents to treat Neuromuscular Disorders,” grand rounds, University cystic fibrosis lung disease: (1) a phase III, randomized, of Pittsburgh, Department of Pediatrics, Children’s double-blind, placebo-controlled study of inhaled vanco- Hospital of Pittsburgh, February 2016 mycin for the treatment of persistent methicillin-resistant • Creator and organizer, Respiratory Outcomes in Staphylococcus aureus lung infection in cystic fibrosis Muscular Dystrophy, meeting of Parent Project Muscular patients and (2) a phase III, open-label study to evaluate Dystrophy, U.S. Food and Drug Administration, NIH, the pharmacokinetics, safety, and of VX661 in international research community, and industry to result combination with Ivacaftor in subjects 6 through 11 years in a consensus statement, April 2016

DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

• “Respiratory Management of Muscular Dystrophy,” childhood asthma. He has recruited for a study looking at Parent Project Muscular Dystrophy annual meeting, the epigenetics and genomics of adipose tissue and child- Orlando, Fla., June 2016 hood asthma, and he has participated in ongoing studies • “Respiratory Management of Duchenne Muscular of epigenetics of asthma in Puerto Rico and of vitamin D Dystrophy,” Muscular Dystrophy Foundation of South supplementation for persistent asthma. Africa regional workshop, Hope School, Johannesburg, South Africa, August 2016 EDITORSHIPS • “Respiratory Management of Duchenne Muscular • Review Board, Journal of Allergy and Clinical Immunology Dystrophy,” Muscular Dystrophy Foundation of South • Ad hoc reviewer, American Journal of Respiratory and Africa regional workshop, Albert Lethuli Hospital, Critical Care Medicine Durban, South Africa, August 2016 • Ad hoc reviewer, Journal of Allergy and Clinical • “Respiratory Management of Duchenne Muscular Immunology–In Practice Dystrophy,” Muscular Dystrophy Foundation of South • Ad hoc reviewer, The Lancet Respiratory Medicine Africa regional workshop, Red Cross Hospital, Cape • Ad hoc reviewer, Annals of the American Thoracic Society Town, South Africa, September 2016 • Ad hoc reviewer, European Respiratory Journal • “Respiratory Management of Duchenne Muscular • Ad hoc reviewer, Pediatrics 299 Dystrophy,” South African Paediatric Association Second • Ad hoc reviewer, Chest Biennial Congress, Durban, South Africa, September 2016 • Ad hoc reviewer, Pharmacogenomics Journal • “Respiratory Management of Patients with • Ad hoc reviewer, PLOS ONE Neuromuscular Disorders,” Pennsylvania Society • Ad hoc reviewer, Pediatric Pulmonology for Respiratory Care Western Regional Conference, • Ad hoc reviewer, Annals of Allergy, Asthma, and Immunology Cranberry, Pa., September 2016 • Ad hoc reviewer, Thorax • “Respiratory Management of Patients with Neuro- • Ad hoc reviewer, muscular Disorders,” grand rounds, Department of • Ad hoc reviewer, Journal of Pediatrics Pediatrics, Nationwide Children’s Hospital, University • Ad hoc reviewer, Reviews of Ohio, December 2016 • Ad hoc reviewer, Journal of Asthma • “Pulmonary Secrets for Pediatricians,” grand rounds, • Ad hoc reviewer, Jornal de Pediatria (Brasil) Children’s Hospital of Pittsburgh, October 2017 MAJOR LECTURESHIPS AND SEMINARS • “Standards of Care,” Parent Project Muscular • “Multi-Omics Approach to Identify Genes Associated Dystrophy, Boston regional conference, October 2017 With Childhood Asthma Risk and Morbidity,” PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS mini-symposium, ATS international conference, • Advisor to board, Parent Project Muscular Dystrophy, San Francisco, Calif., May 2016 1999 to the present • “Omics of Environmental Lung Disease,” co-chair, • ATS, 1991 to the present mini-symposium, ATS international conference, San Francisco, Calif., May 2016 HONORS • “Obesity and Asthma in Children,” guest speaker, • Best Doctors, Pittsburgh Magazine, 2012–2016 Chronic Diseases in Low- and Middle-Income • Best Doctors in America, Woodward/White, Inc., Countries course, Johns Hopkins Bloomberg School of 2003–2017 , Baltimore, Md., August 2016 • 2013 Care Center Champion Award, Cystic Fibrosis • “Obesity, Stress, and Asthma,” guest speaker, Societal Foundation, 2014 Change, Asthma, and Allergy in Latin America • University of Pittsburgh School of Medicine’s Sheldon international meeting, Salvador da Bahía, Brazil, Adler Innovation in Medical Education Award, 2017 December 2016 • “Childhood Obese Asthma,” guest speaker, Pulmonary Division, University of Wisconsin School of Medicine Erick Forno, MD, MPH and Public Health, Madison, Wis., January 2017 RESEARCH • “Obesity and Asthma in Children” and “Severe Phenotypes Erick Forno studies the environmental and genetic risk of Childhood Asthma,” guest speaker, XXX Central factors for asthma and asthma severity in children. His American and Caribbean Congress of Pulmonology and primary focus is on the effect of overweight and obesity on Thoracic , San Jose, Costa Rica, March 2017

DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

• “Obese Asthma in Pediatrics,” guest speaker, 39th • Ad hoc reviewer, Allergy (European Journal of Allergy and Conference of the German Pediatric Pulmonology Clinical Immunology) Association, Essen, Germany, March 2017 • Ad hoc reviewer, Annals of Allergy, Asthma, and Immunology • “Obesity and Asthma” and “Asthma Management Beyond • Ad hoc reviewer, Immunotherapy Monotherapy,” invited lectures, Panama Respiratory • Ad hoc reviewer, Journal of Allergy and Clinical Immunology Symposium, Panama City, Panama, April 2017 • Ad hoc reviewer, Journal of Allergy and Clinical • “A Pro/Con Debate in Pediatric Asthma,” co-chair, Immunology–In Practice Scientific Symposium, ATS international conference, • Ad hoc reviewer, Journal of Asthma Washington, D.C., May 2017 • Ad hoc reviewer, Journal of Pediatric • “Obesity and Chronic Respiratory Diseases in Children: and Nutrition Recent Advances and Clinical Implications,” co-chair, • Ad hoc reviewer, New England Journal of Medicine scientific symposium, ATS international conference, • Ad hoc reviewer, Pediatrics Washington, D.C., May 2017 ADVISORY COMMITTEE MEMBERSHIPS PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS • Outcomes Research Advisory Board, Patient-Centric • ATS 300 Food Allergy Research Program, FARE, supported • American Society of Human Genetics by the Patient-Centered Outcomes Research Institute • Society for Pediatric Research through the Eugene Washington Engagement Award • Medical Advisory Board, International FPIES (food HONORS protein–induced enterocolitis syndrome) Association • Accepted to the Society for Pediatric Research, 2013 • UPMC Patient Experience Advisory Group • Member, Program Committee, ATS Assembly of • Clinical Advisory Board, FARE Pediatrics, 2015–2018 • Medical-Scientific Council, Asthma and Allergy • Mentored Career Development Award (K08), NIH, Foundation of America 2015–2019 • Medical Advisory Team, Kids With Food Allergies • Research Advisory Committee Award, Children’s • Medical advisor, Epi-Life, Food Allergy Parent Hospital of Pittsburgh, 2015–2016 Support Group • Klostenfrau International Award for Research of Airway • Education Committee, Children’s Hospital of Diseases in Childhood, German Society of Pediatric Pittsburgh of UPMC Pulmonology, 2017 • Pediatric Residency Selection Committee, Children’s • Robert B. Mellins Achievement Award for Outstanding Hospital of Pittsburgh of UPMC Research, Assembly on Pediatrics, ATS, 2017 PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS Todd D. Green, MD • Fellow, American Academy of Allergy, Asthma, and Immunology RESEARCH • Representative to the Council of Pediatric Todd D. Green serves as director for the FARE Center from the American Academy of Allergy, Asthma, of Excellence at Children’s Hospital of Pittsburgh of and Immunology UPMC. In that position, he serves as principal investigator • Governor, Region 2, Federation of the Regional, State, for multiple clinical trials looking at novel potential thera- and Local American Association of Immunologists pies for food allergy, a condition for which there is currently Societies Assembly no treatment. He continues to serve as principal investigator • Pediatrics Councilor, Program Directors Assembly in studies examining quality-of-life issues in children with • Executive Committee, American Academy of Allergy, food allergy, as well as characterizing outcomes of oral food Asthma, and Immunology challenges. Green was a co-investigator (collaborating with • Clinical Immunology Society William Doyle, principal investigator) on a pilot study of the • Past president, Board of Regents, Pennsylvania Allergy effect of intranasal ragweed challenge in adult allergy rhinitis and Asthma Association subjects on middle-ear pressure regulation. MAJOR LECTURESHIPS AND SEMINARS EDITORSHIPS • “Primary Prevention of Food Allergy,” Children’s • Section editor (Food Allergy), Current Allergy and Community Pediatrics, “Lunch ‘N Learn” teleconfer- Asthma Reports ence, Pittsburgh, Pa., June 2016

DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

• “Food Allergy Potpourri: FPIES, FIEP, FPE, LEAP ...,” Geoffrey Kurland, MD faculty, Three Rivers Pediatric Update, Children’s Hospital EDITORSHIPS of Pittsburgh of UPMC, Pittsburgh, Pa., May 2016 • Associate editor, lung transplantation, Journal of • “Pediatric Allergy Cases,” faculty, 11th Annual Update in Pediatric Transplantation Sino-Nasal Disorders and Allergy, University of Pittsburgh School of Medicine, Pittsburgh, Pa., May 2016 PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS • “Participating in a Research Study,” webinar offered by • Pediatric Pulmonary Sub-Board, American Academy of FARE, April 2016 Pediatrics • Pediatric Planning Committee, ATS Yueh-Ying Han, PhD, MS • Pediatric Interstitial Lung Disease Consortium • Medical volunteer, Western States 100-Mile Endurance RESEARCH Run, Sierra Mountains, Calif. Using epidemiological methodologies and quantitative • Alpha Omega Alpha analysis, Yueh-Ying Han studies etiology and risk factors for • American Academy of Pediatrics asthma and asthma severity in children. Her primary study • American Pediatric Society is on dietary and nutritional intake in association with child- 301 • American Society of Transplant Physicians hood asthma. She works closely with fellows and colleagues • ATS in various pulmonary studies. She also serves as the overall • European Respiratory Society data manager for Celedón’s research group, participating in • International Pediatric Transplantation Association several study projects at UPMC and Children’s Hospital of • International Society of and Lung Transplantation Pittsburgh of UPMC. • Pediatric Pulmonary Training Directors Association

EDITORSHIPS • Ad hoc reviewer, Pediatric Allergy and Immunology Allyson Larkin, MD • Ad hoc reviewer, American Journal of Public Health RESEARCH

PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS Allyson Larkin is involved in multiple asthma-related • American Public Health Association projects. She continues work on developing an asthma game • Society for Epidemiology Research that will enhance understanding of treatment and disease processes. She sees patients in the Severe Asthma Research TEACHING ACTIVITIES Program and works to develop an active asthma registry. • “Environmental Epidemiology,” guest lecturer, University She participates in the following studies. of Pittsburgh Graduate School of Public Health, Pittsburgh, Pa., January–April 2016

DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

• Best African American Response to Asthma Drugs ADVISORY COMMITTEE MEMBERSHIPS • Step-Up Yellow Zone Inhaled Corticosteroids to • for Technology Dependent Children Program, Prevent Exacerbations Children’s Hospital of Pittsburgh, 2014 to the present • Peanut Allergy Oral Immunotherapy Study of AR101 for Desensitization in Children and Adults (Palisade) EDITORSHIPS • A Double-Blind, Placebo-Controlled, Randomized • Reviewer, American Journal of Respiratory and Critical Phase III Pivotal Trial to Assess the Efficacy and Safety Care Medicine of Peanut Epicutaneous Immunotherapy With Viaskin® • Reviewer, Chest Peanut in Peanut-Allergic Children • Reviewer, Pediatric Pulmonology • A Double-Blind, Placebo-Controlled Randomized Trial • Reviewer, Sleep to Study Viaskin® Milk Efficacy and Safety for Treating • Reviewer, Sleep Medicine IgE-Mediated Cow’s Milk Allergy in Children • Reviewer, International Journal of Pediatric Otolaryngology • Reviewer, Annals of the American Thoracic Society ADVISORY COMMITTEE MEMBERSHIPS • Reviewer, Journal of Clinical Sleep Medicine • Pennsylvania Allergy and Asthma Association Board of 302 Regents, June 2013 MAJOR LECTURESHIPS AND SEMINARS • Children’s Community Pediatrics Asthma • “Pediatric Obstructive Sleep ,” annual Pennsylvania Care Program Society for Respiratory Care Western Regional Conference • Accreditation Council for Graduate Medical Education on Respiratory and Sleep Medicine, October 2015 • Clinical Competency Committee, Allergy/Immunology • “Sleep Update,” Three Rivers Pediatric Update, Children’s Fellowship Program Hospital of Pittsburgh, Pittsburgh, Pa., May 2016 • Curriculum and Program Evaluation Committee, HONORS Allergy/Immunology Fellowship Program • Best Doctors, , 2014 to the present • Research Committee, Allergy/Immunology Pittsburgh Magazine Fellowship Program PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS

MAJOR LECTURESHIPS AND SEMINARS • ATS • American Academy of Sleep Medicine • “Review of Primary Immunodeficiencies Related to B-Cell Defects and Phagocytic Defects,” Immunology in Health and Disease, University of Pittsburgh School of David M. Orenstein, MD, MA Medicine, Pittsburgh, Pa., February 2016 RESEARCH • “Food Allergy Awareness,” St. Edmond’s Academy, David Orenstein’s 37-year research career has focused on Pittsburgh, Pa., May 2016 various aspects of exercise in patients with cystic fibrosis and • “Use of Anti-IL4/IL5 in Allergic Disease,” other lung disorders. Orenstein continues as the principal grand rounds, Allergy and Immunology, Children’s investigator of the Pittsburgh Translational Center for Hospital of Pittsburgh, Pittsburgh, Pa., May 2016 the Cystic Fibrosis Foundation’s National Therapeutics • “Review of Primary Immunodeficiencies Related to Development Network and as a driving force in many B-Cell Defects and Phagocytic Defects,” Immunology in multicenter clinical studies. Health and Disease, University of Pittsburgh Medical School, Pittsburgh, Pa., March 2017 ADVISORY COMMITTEE MEMBERSHIPS • “Gateway Asthma Webinar,” Pittsburgh, Pa., August 2017 • Board of Trustees, Western Pennsylvania Chapter, Cystic Fibrosis Foundation PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS • Chair, Ethics Committee, Children’s Hospital of • Pennsylvania Allergy and Asthma Association Pittsburgh of UPMC • American Academy of Allergy, Asthma, and Immunology • Data Safety Committee, Cystic Fibrosis Foundation Therapeutics Development Network Hiren Muzumdar, MD • Pediatric Pulmonary Fellowship Programs, Appeals

RESEARCH Panel for the Accreditation Council for Graduate Medical Education Hiren Muzumdar is an investigator in a study on sleep • Professional Education and Training Committee, disturbances in recent survivors of childhood cancer. Cystic Fibrosis Foundation (national)

DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

• Chair, Publications and Presentations Committee, EDITORSHIPS Cystic Fibrosis Foundation Therapeutics • Ad hoc reviewer, CHEST Development Network • Ad hoc reviewer, Pediatric Emergency Care • Ad hoc reviewer, European Respiratory Journal PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS • Ad hoc reviewer, American Journal of Respiratory and • American Academy of Pediatrics Critical Care Medicine • American College of • Ad hoc reviewer, Pediatric Pulmonology • American Pediatric Society • Ad hoc reviewer, and Analgesia • American Society for Bioethics and Humanities • Ad hoc reviewer, Journal of Cystic Fibrosis • Cystic Fibrosis Foundation • Ad hoc reviewer, Acta Pathologica, Microbiologica, et • Society for Pediatric Research Immunologica Scandinavica • Center for Bioethics and Health Law • Ad hoc reviewer, Journal of Pediatrics • Ad hoc reviewer, Journal of Asthma HONORS • Ad hoc reviewer, Respiratory Care • Best Doctors in America, Woodward/White, Inc., • Ad hoc reviewer, International Journal of Radiation 1989 to the present , Biology, Physics 303 • Antonio J. and Janet Palumbo Professor of Cystic • Review editor, Frontiers in Pediatric Pulmonology Fibrosis, Children’s Hospital of Pittsburgh of UPMC

• Health Care Heroes Lifetime Achievement Award, MAJOR LECTURESHIPS AND SEMINARS Pittsburgh Business Times, 2015 • “Cystic Fibrosis,” Pennsylvania Association of Physician Assistants, Greentree, Pa., October 2016 Daniel J. Weiner, MD • “,” lecture for pulmonary research coordi- nators, Division of Pulmonary Medicine, Children’s RESEARCH Hospital of Pittsburgh, October 2016 Daniel Weiner is the local principal investigator for a • “Spirometry and Beyond,” grand rounds, Section number of multicenter cystic fibrosis clinical trials, including of Allergy and Immunology, Children’s Hospital of studies of novel pharmaceuticals to enhance ion transport, Pittsburgh, November 2016 pancreatic enzyme–replacement therapies, and hydrating • “What About the Kids? Special Considerations for Pediatric therapies (hypertonic saline). He continues to investigate Pulmonary Function Measurement and Interpretation” measurements from multiple-breath washout studies as an and “PG-21 Pulmonary Function and Cardiopulmonary outcome for clinical trials in cystic fibrosis. Exercise Testing: Moving From Theory to Clinical Practice,” ATS international conference, Washington, D.C., COMMITTEE MEMBERSHIPS May 2017 • Center Committee, Cystic Fibrosis Foundation • “To Spirometry and Beyond: Advanced Pulmonary • Proficiency Standards for Pulmonary Function Function Testing,” grand rounds, Section of Allergy Laboratories Committee, ATS and Immunology, Children’s Hospital of Pittsburgh, • Board of Directors, Western Pennsylvania Chapter October 2017 of the Cystic Fibrosis Foundation

• Proficiency Standards for Pulmonary Function PROFESSIONAL AFFILIATIONS/SOCIETY MEMBERSHIPS Laboratories Committee, ATS • Alpha Omega Alpha • Accreditation for Pulmonary Function Laboratories • American College of Chest Physicians Committee, ATS • ATS • Sub-Board of Pediatric Pulmonology, American Board • European Respiratory Society of Pediatrics • PENTEC (Pediatric Normal Tissue Effects in the HONORS Clinic) Working Group • Outstanding Cystic Fibrosis Advocate Award, Cystic • Pulmonary Working Group, Children’s Fibrosis Foundation, 2016 Oncology Group • Outstanding Mini-Elective, University of Pittsburgh • Pulmonary Dysfunction Guidelines International School of Medicine, October 2017 Harmonisation Group

DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

TEACHING ACTIVITIES

he division has two training programs accredited by the Accreditation Council for Graduate Medical Education (Pediatric Pulmonary Medicine and Allergy/Immunology). Six fellows currently are in training in the Pulmonary T Medicine Program, and four fellows currently are in training in the Allergy/Immunology Program. The division’s clinics serve as a popular elective rotation for medical students and residents.

The faculty teaches classes in molecular medicine and integrated life science; directs journal clubs and research confer- ences; bolsters training in other departments (e.g., the School of , Otolaryngology, Pediatric Critical Care); and participates in the Unified Fellows Course. The division’s educational efforts included three predoctoral students, one of whom was in the Medical Scientist Training Program; two summer students; one summer undergraduate student; and two medical student researchers.

THREE-YEAR BIBLIOGRAPHY

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DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

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DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

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DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT DIVISION OF PULMONARY MEDICINE, ALLERGY, AND IMMUNOLOGY

Rosser F, Forno E, Brehm J, Han W, Canino G, Burchard E, Celedón Puranik S, Forno E, Bush A, Celedón YY, Boutaoui N, Colón-Semidey A, JC. An epigenome-wide association JC. Predicting severe asthma exacerba- Alvarez M, Acosta-Pérez E, Kurland study of total serum immunoglobulin tions in children. Am J Respir Crit Care K, Alcorn J, Canino G, Celedón JC. E in Hispanic children. J Allergy Clin Med. 2017;195(7):854-9. Proximity to a major road and plasma Immunol. 2017;140(2):571-7. cytokines in school-aged children. Yan Q, Brehm J, Pino-Yanes M, Forno Pediatr Allergy Immunol Pulmonol. Forno E, Weiner D, Mullen J, Sa- E, Lin J, Oh SS, Acosta-Perez E, Laurie 2016;29(3):111-7. wicki G, Kurland G, Han Y, Cloutier CC, Cloutier MM, Raby BA, Stilp AM, M, Canino G, Weiss S, Litonjua A, Sofer T, Hu D, Huntsman S, Eng CS, Szentpetery SE, Forno E, Canino G, Celedón JC. Obesity and airway dys- Conomos MP, Rastogi D, Rice K, Celedón JC. 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DEPARTMENT OF PEDIATRICS 2017 ANNUAL REPORT