September 29, 2020 u vol. 117 u no. 39

From the Cover

24526 Nanoscale organization of glutamate receptors 24039 Treatment of adolescent mental illness 24117 Causal inferences of genetic data 24127 Ancient floodwater farming 24258 Conformation of proto-oncogene

Contents

THIS WEEK IN PNAS—This week’s research highlights Cover image: Pictured is 24005 In This Issue a reconstruction of glutamate receptor clusters. Joana S. Ferreira et al. found that in rat hippocampal neurons, the QNAS—Interviews with leading scientific researchers and newsmakers nanoscale organization and lateral 24008 QnAs with Janet Currie diffusion of N-methyl-D-aspartate Tinsley H. Davis receptors (NMDAR) changed in See Inaugural Article on page 24039 a subunit-specific manner along dendritic segments in relation to distance from the soma. The interplay PROFILE—The life and work of NAS members between NMDAR and calcium/ 24010 Profile of Cynthia Friend calmodulin-dependent protein kinase II Farooq Ahmed (CaMKII) shaped synaptic potentiation. The findings suggest that the nanoscale organization of both NMDAR and COMMENTARIES CaMKII may influence the plasticity of synaptic inputs. See the article by 24013 The immune signatures of multiple sclerosis: Lessons from twin studies Ferreira et al. on pages 24526–24533. Pablo Villoslada and Scott S. Zamvil Image credit: Joana S. Ferreira. See companion article on page 21546 in issue 35 of volume 117 24016 Predators and rainfall control spatial biogeochemistry in a landscape of fear Oswald J. Schmitz See companion article on page 22256 in issue 36 of volume 117 24019 Expanding the horizons of genome editing in the fruit fly with Cas12a Ben Ewen-Campen and Norbert Perrimon See companion article on page 22890 in issue 37 of volume 117

PERSPECTIVE 24022 Opportunities and limitations of genetically modified nonhuman primate models for neuroscience research Guoping Feng, Frances E. Jensen, Henry T. Greely, Hideyuki Okano, Stefan Treue, Angela C. Roberts, James G. Fox, Sarah Caddick, Mu-ming Poo, William T. Newsome, and John H. Morrison

LETTERS 24032 Using the curriculum vitae to promote gender equity during the COVID-19 pandemic Vineet M. Arora, Charles M. Wray, Avital Y. O’Glasser, Mark Shapiro, and Shikha Jain

Free online through the PNAS open access option. PNAS u September 29, 2020 u vol. 117 u no. 39 u iii–vii Downloaded by guest on September 28, 2021 24033 Reply to Arora et al.: Concerns and considerations EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES about using the CV as an equity tool 24082 Modeling the stability of polygonal patterns of vortices at Jessica L. Malisch, Breanna N. Harris, Shanen M. Sherrer, the poles of Jupiter as revealed by the Juno spacecraft Kristy A. Lewis, Stephanie L. Shepherd, Pumtiwitt C. McCarthy, Cheng Li, Andrew P. Ingersoll, Alexandra P. Klipfel, and Harriet Brettle Jessica L. Spott, Elizabeth P. Karam, Naima Moustaid-Moussa, – Jessica McCrory Calarco, Latha Ramalingam, Amelia E. Talley, 24088 The seawater carbon inventory at the Paleocene Jaclyn E. Can˜as-Carrell, Karin Ardon-Dryer, Dana A. Weiser, Eocene Thermal Maximum Ximena E. Bernal, and Jennifer Deitloff Laura L. Haynes and Ba¨rbel Ho¨nisch 24035 Genetic variant rs7820258 regulates the expression ENGINEERING of indoleamine 2,3-dioxygenase 1 in brain regions 24096 Untethered control of functional origami microrobots Zhijie Han, Dian He, and Yang Zhang with distributed actuation 24037 Reply to Han et al.: On track for an IDO1-based Larissa S. Novelino, Qiji Ze, Shuai Wu, Glaucio H. Paulino, and Ruike Zhao personalized therapy in autoimmunity 24205 Engineered biomimetic nanoparticle for dual targeting Giada Mondanelli, Agostinho Carvalho, Paolo Puccetti, Ursula of the cancer stem-like cell population in sonic Grohmann, and Claudia Volpi hedgehog medulloblastoma Jinhwan Kim, Abhinav Dey, Anshu Malhotra, Jingbo Liu, Song Ih Ahn, Yoshitaka J. Sei, Anna M. Kenney, Tobey J. MacDonald, and YongTae Kim INAUGURAL ARTICLE PHYSICS 24039 Treatment of mental illness in American adolescents varies widely within and across areas 24102 Geodesic fibrations for packing diabolic domains Randall D. Kamien and Thomas Machon Emily Cuddy and Janet Currie See QnAs on page 24008 24110 Emergence of anomalous dynamics in soft matter probed at the European XFEL Felix Lehmku¨hler, Francesco Dallari, Avni Jain, Marcin Sikorski, BRIEF REPORT Johannes Mo¨ller, Lara Frenzel, Irina Lokteva, Grant Mills, Michael 24047 Early preference for face-like stimuli in solitary Walther, Harald Sinn, Florian Schulz, Michael Dartsch, Verena Markmann, Richard Bean, Yoonhee Kim, Patrik Vagovic, Anders species as revealed by tortoise hatchlings Madsen, Adrian P. Mancuso, and Gerhard Gru¨bel Elisabetta Versace, Silvia Damini, and Gionata Stancher STATISTICS 24117 Causal inference in genetic trio studies PHYSICAL SCIENCES Stephen Bates, Matteo Sesia, Chiara Sabatti, and Emmanuel Cande`s

APPLIED PHYSICAL SCIENCES 24173 National population mapping from sparse survey data: A hierarchical Bayesian modeling framework 24050 Near-zero-index media as electromagnetic ideal fluids to account for uncertainty In˜igo Liberal, Michae¨l Lobet, Yue Li, and Nader Engheta Douglas R. Leasure, Warren C. Jochem, Eric M. Weber, Vincent 24055 Shear-assisted grain coarsening in Seaman, and Andrew J. Tatem colloidal polycrystals Wei Li, Yi Peng, Yongjun Zhang, Tim Still, A. G. Yodh, SOCIAL SCIENCES and Yilong Han 24336 Functional advantages of Lévy walks emerging near ANTHROPOLOGY a critical point 24127 El Niño resilience farming on the north coast of Peru Masato S. Abe Ari Caramanica, Luis Huaman Mesia, Claudia R. Morales, Gary Huckleberry, Luis Jaime Castillo B., and Jeffrey Quilter BIOPHYSICS AND COMPUTATIONAL BIOLOGY ECONOMIC SCIENCES 24224 Interfacial plasticity facilitates high reaction rate of 24039 Treatment of mental illness in American adolescents E. coli FAS malonyl-CoA:ACP transacylase, FabD varies widely within and across areas Laetitia E. Misson, Jeffrey T. Mindrebo, Tony D. Davis, Ashay Emily Cuddy and Janet Currie Patel, J. Andrew McCammon, Joseph P. Noel, and Michael D. Burkart See QnAs on page 24008 ENVIRONMENTAL SCIENCES CHEMISTRY 24138 Holocene coastal evolution preceded the expansion 24061 Exploring the landscape of model representations of paddy field rice farming Thomas T. Foley, Katherine M. Kidder, M. Scott Shell, Ting Ma, Barry V. Rolett, Zhuo Zheng, and Yongqiang Zong and W. G. Noid 24345 Synchrony matters more than species richness in 24069 Visualizing conical intersection passages via vibronic plant community stability at a global scale coherence maps generated by stimulated ultrafast Enrique Valencia, Francesco de Bello, Thomas Galland, Peter B. X-ray Raman signals Adler, Jan Leps, Anna E-Vojtko´, Roel van Klink, Carlos P. Daniel Keefer, Thomas Schnappinger, Regina de Vivie-Riedle, Carmona, Jirı´ Danihelka, Ju¨rgen Dengler, David J. Eldridge, and Shaul Mukamel Marc Estiarte, Ricardo Garcı´a-Gonza´lez, Eric Garnier, Daniel 24076 Polyamorphism of vapor-deposited amorphous Go´mez‐Garcı´a, Susan P. Harrison, Toma´sHerben,Ricardo selenium in response to light Iba´n˜ez, Anke Jentsch, Norbert Juergens, Miklo´s Kerte´sz, Katja Aixi Zhang, Yi Jin, Tianyi Liu, Richard B. Stephens, Klumpp, Fre´de´rique Louault, Rob H. Marrs, Roma`Ogaya,Ga´bor ´ and Zahra Fakhraai Onodi, Robin J. Pakeman, Iker Pardo, Meelis Pa¨rtel, Begon˜aPeco, Josep Pen˜uelas, Richard F. Pywell, Marta Rueda, Wolfgang 24251 Thermodynamic and kinetic design principles for Schmidt, Ute Schmiedel, Martin Schuetz, Hana Ska´lova´, Petr   amyloid-aggregation inhibitors Smilauer, Marie Smilauerova´, Christian Smit, MingHua Song,  Thomas C. T. Michaels, Andela Saric, Georg Meisl, Gabriella Martin Stock, James Val, Vigdis Vandvik, David Ward, Karsten T. Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher Wesche, Susan K. Wiser, Ben A. Woodcock, Truman P. Young, M. Dobson, Michele Vendruscolo, and Tuomas P. J. Knowles Fei-Hai Yu, Martin Zobel, and Lars Go¨tzenberger

iv u www.pnas.org Contents Downloaded by guest on September 28, 2021 POLITICAL SCIENCES BIOCHEMISTRY 24144 Political partisanship influences behavioral responses 24224 Interfacial plasticity facilitates high reaction rate of to governors’ recommendations for COVID-19 E. coli FAS malonyl-CoA:ACP transacylase, FabD prevention in the United States Laetitia E. Misson, Jeffrey T. Mindrebo, Tony D. Davis, Ashay Guy Grossman, Soojong Kim, Jonah M. Rexer, Patel, J. Andrew McCammon, Joseph P. Noel, and Harsha Thirumurthy and Michael D. Burkart 24234 Ribulose 1,5-bisphosphate carboxylase/oxygenase PSYCHOLOGICAL AND COGNITIVE SCIENCES activates O2 by electron transfer 24154 Open science, communal culture, and women’s Camille Bathellier, Li-Juan Yu, Graham D. Farquhar, participation in the movement to improve science Michelle L. Coote, George H. Lorimer, Mary C. Murphy, Amanda F. Mejia, Jorge Mejia, Xiaoran Yan, and Guillaume Tcherkez Sapna Cheryan, Nilanjana Dasgupta, Mesmin Destin, Stephanie A. 24243 Victorin, the host-selective cyclic peptide toxin from Fryberg, Julie A. Garcia, Elizabeth L. Haines, Judith M. Harackiewicz, the oat pathogen Cochliobolus victoriae,is Alison Ledgerwood, Corinne A. Moss-Racusin, Lora E. Park, ribosomally encoded Sylvia P. Perry, Kate A. Ratliff, Aneeta Rattan, Diana T. Sanchez, Simon C. Kessler, Xianghui Zhang, Megan C. Krishna Savani, Denise Sekaquaptewa, Jessi L. Smith, Valerie McDonald, Cameron L. M. Gilchrist, Zeran Lin, Adriana Jones Taylor, Dustin B. Thoman, Daryl A. Wout, Patricia L. Rightmyer, Peter S. Solomon, B. Gillian Turgeon, Mabry, Susanne Ressl, Amanda B. Diekman, and Franco Pestilli and Yit-Heng Chooi 24581 Hierarchical structure is employed by humans during visual motion perception Johannes Bill, Hrag Pailian, Samuel J. Gershman, BIOPHYSICS AND COMPUTATIONAL BIOLOGY and Jan Drugowitsch 24061 Exploring the landscape of model representations Thomas T. Foley, Katherine M. Kidder, M. Scott Shell, SOCIAL SCIENCES and W. G. Noid 24165 Fifty years of capacity building in the search for new 24251 Thermodynamic and kinetic design principles for marine natural products amyloid-aggregation inhibitors  Miguel C. Leal, Jaime M. Anaya-Rojas, Murray H. G. Munro, John W. Thomas C. T. Michaels, Andela Saric, Georg Meisl, Gabriella Blunt, Carlos J. Melian, Ricardo Calado, and Moritz D. Lu¨rig T. Heller, Samo Curk, Paolo Arosio, Sara Linse, Christopher 24173 National population mapping from sparse survey M. Dobson, Michele Vendruscolo, and Tuomas P. J. Knowles data: A hierarchical Bayesian modeling framework 24258 Uncovering a membrane-distal conformation of to account for uncertainty KRAS available to recruit RAF to the Douglas R. Leasure, Warren C. Jochem, Eric M. Weber, Vincent plasma membrane Seaman, and Andrew J. Tatem Que N. Van, Cesar A. Lo´pez, Marco Tonelli, Troy Taylor, Ben 24180 Spatial heterogeneity can lead to substantial local Niu, Christopher B. Stanley, Debsindhu Bhowmik, Timothy H. variations in COVID-19 timing and severity Tran, Peter H. Frank, Simon Messing, Patrick Alexander, Loring J. Thomas, Peng Huang, Fan Yin, Xiaoshuang Iris Luo, Daniel Scott, Xiaoying Ye, Matt Drew, Oleg Chertov, Mathias Zack W. Almquist, John R. Hipp, and Carter T. Butts Lo¨sche, Arvind Ramanathan, Michael L. Gross, Nicolas W. Hengartner, William M. Westler, John L. Markley, Dhirendra K. Simanshu, Dwight V. Nissley, William K. Gillette, Dominic SUSTAINABILITY SCIENCE Esposito, Frank McCormick, S. Gnanakaran, Frank Heinrich, 24188 Overstated carbon emission reductions from and Andrew G. Stephen voluntary REDD+ projects in the Brazilian Amazon 24269 General and robust covalently linked graphene oxide Thales A. P. West, Jan Borner, Erin O. Sills, ¨ affinity grids for high-resolution cryo-EM and Andreas Kontoleon Feng Wang, Yanxin Liu, Zanlin Yu, Sam Li, Shengjie Feng, Yifan Cheng, and David A. Agard BIOLOGICAL SCIENCES 24274 Proline-rich domain of human ALIX contains AGRICULTURAL SCIENCES multiple TSG101-UEV interaction sites and forms phosphorylation-mediated 24195 Donor-derived spermatogenesis following stem cell reversible amyloids transplantation in sterile NANOS2 knockout males Ruben D. Elias, Wen Ma, Rodolfo Ghirlando, Charles D. Michela Ciccarelli, Mariana I. Giassetti, Deqiang Miao, Schwieters, Vijay S. Reddy, and Lalit Deshmukh Melissa J. Oatley, Colton Robbins, Blanca Lopez-Biladeau, Muhammad Salman Waqas, Ahmed Tibary, Bruce Whitelaw, 24285 Disruption of a key ligand-H-bond network drives Simon Lillico, Chi-Hun Park, Ki-Eun Park, Bhanu Telugu, dissociative properties in vamorolone for Zhiqiang Fan, Ying Liu, Misha Regouski, Irina A. Polejaeva, Duchenne muscular dystrophy treatment and Jon M. Oatley Xu Liu, Yashuo Wang, Jennifer S. Gutierrez, Jesse M. Damsker, Kanneboyina Nagaraju, Eric P. Hoffman, and Eric A. Ortlund APPLIED BIOLOGICAL SCIENCES 24294 Supertertiary protein structure affects an 24205 Engineered biomimetic nanoparticle for dual targeting allosteric network of the cancer stem-like cell population in sonic Louise Laursen, Johanna Kliche, Stefano Gianni, and Per Jemth hedgehog medulloblastoma Jinhwan Kim, Abhinav Dey, Anshu Malhotra, Jingbo Liu, Song Ih Ahn, 24305 Tuning the Baird aromatic triplet-state energy of Yoshitaka J. Sei, Anna M. Kenney, Tobey J. MacDonald, and YongTae Kim cyclooctatetraene to maximize the self-healing mechanism in organic fluorophores 24213 Extracellular microRNAs in human circulation are associated Avik K. Pati, Ouissam El Bakouri, Steffen Jockusch, Zhou Zhou, with miRISC complexes that are accessible to anti- Roger B. Altman, Gabriel A. Fitzgerald, Wesley B. Asher, AGO2 antibody and can bind target Daniel S. Terry, Alessandro Borgia, Michael D. Holsey, Jake E. mimic oligonucleotides Batchelder, Chathura Abeywickrama, Brandt Huddle, Dominic Hirosha Geekiyanage, Shima Rayatpisheh, James A. Rufa, Jonathan A. Javitch, Henrik Ottosson, Wohlschlegel, Robert Brown Jr, and Victor Ambros and Scott C. Blanchard

Contents PNAS u September 29, 2020 u vol. 117 u no. 39 u v Downloaded by guest on September 28, 2021 CELL BIOLOGY 24377 A CRISPR homing gene drive targeting a haplolethal 24316 Hemostasis vs. homeostasis: Platelets are essential gene removes resistance alleles and successfully for preserving vascular barrier function in the spreads through a cage population absence of injury or inflammation Jackson Champer, Emily Yang, Esther Lee, Jingxian Liu, Shuchi Gupta, Christoph Konradt, Adam Corken, Jerry Ware, Andrew G. Clark, and Philipp W. Messer Bernhard Nieswandt, Jorge Di Paola, Mei Yu, Demin Wang, Marvin T. Nieman, Sidney W. Whiteheart, IMMUNOLOGY AND INFLAMMATION + and Lawrence F. Brass 24384 Suboptimal SARS-CoV-2−specific CD8 T cell 24326 Kindlin-3 loss curbs chronic myeloid leukemia in mice response associated with the prominent HLA- by mobilizing leukemic stem cells from protective A*02:01 phenotype bone marrow niches Jennifer R. Habel, Thi H. O. Nguyen, Carolien E. van de Sandt, Peter William Krenn, Steffen Koschmieder, Jennifer A. Juno, Priyanka Chaurasia, Kathleen Wragg, Marios and Reinhard Fa¨ssler Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L. Flanagan, Denise L. Doolan, Joseph Torresi, Weisan Chen, Linda M. Wakim, Allen C. ECOLOGY Cheng, Peter C. Doherty, Jan Petersen, Jamie Rossjohn, 24336 Functional advantages of Lévy walks emerging near Adam K. Wheatley, Stephen J. Kent, Louise C. Rowntree, a critical point and Katherine Kedzierska + Masato S. Abe 24392 Early programming of CD8 T cell response by the 24345 Synchrony matters more than species richness in orphan nuclear receptor NR4A3 plant community stability at a global scale Livia Odagiu, Salix Boulet, Dave Maurice De Sousa, Jean- Franc¸ois Daudelin, Sandrine Nicolas, and Nathalie Labrecque Enrique Valencia, Francesco de Bello, Thomas Galland, Peter B. Adler, Jan Leps, Anna E-Vojtko´, Roel van Klink, Carlos P. 24403 ORAI1 and ORAI2 modulate murine neutrophil calcium Carmona, Jirı´ Danihelka, Ju¨rgen Dengler, David J. Eldridge, signaling, cellular activation, and host defense Marc Estiarte, Ricardo Garcı´a-Gonza´lez, Eric Garnier, Daniel Derayvia Grimes, Ryan Johnson, Madeline Pashos, Celeste Go´mez‐Garcı´a, Susan P. Harrison, Toma´s Herben, Ricardo Cummings, Chen Kang, Georgia R. Sampedro, Eric Tycksen, Iba´n˜ez, Anke Jentsch, Norbert Juergens, Miklo´s Kerte´sz, Katja Helen J. McBride, Rajan Sah, Clifford A. Lowell, Klumpp, Fre´de´rique Louault, Rob H. Marrs, Roma`Ogaya,Ga´bor and Regina A. Clemens O´ nodi, Robin J. Pakeman, Iker Pardo, Meelis Pa¨rtel, Begon˜aPeco, Josep Pen˜uelas, Richard F. Pywell, Marta Rueda, Wolfgang MEDICAL SCIENCES Schmidt, Ute Schmiedel, Martin Schuetz, Hana Ska´lova´, Petr   Smilauer, Marie Smilauerova´, Christian Smit, MingHua Song, 24415 Tumor regression and resistance mechanisms upon Martin Stock, James Val, Vigdis Vandvik, David Ward, Karsten CDK4 and RAF1 inactivation in KRAS/P53 mutant Wesche, Susan K. Wiser, Ben A. Woodcock, Truman P. Young, lung adenocarcinomas Fei-Hai Yu, Martin Zobel, and Lars Go¨tzenberger Laura Esteban-Burgos, Haiyun Wang, Patricia Nieto, Jie Zheng, Carmen Blanco-Aparicio, Carmen Varela, Gonzalo Go´mez-Lo´pez, Fernando Ferna´ndez-Garcı´a, Manuel ENVIRONMENTAL SCIENCES Sanclemente, Carmen Guerra, Matthias Drosten, Javier 24138 Holocene coastal evolution preceded the expansion Gala´n, Eduardo Caleiras, Jorge Martı´nez-Torrecuadrada, Lluis of paddy field rice farming Fajas, Sheng-Bin Peng, David Santamarı´a, Monica Musteanu, Ting Ma, Barry V. Rolett, Zhuo Zheng, and Yongqiang Zong and Mariano Barbacid 24352 Late lactation in small mammals is a critically sensitive 24427 PIK3CA C-terminal frameshift mutations are novel window of vulnerability to elevated oncogenic events that sensitize tumors to PI3K- α ambient temperature inhibition Zhi-Jun Zhao, Catherine Hambly, Lu-Lu Shi, Zhong-Qiang Bi, Jennifer M. Spangle, Thanh Von, Dean C. Pavlick, Arina Jing Cao, and John R. Speakman Khotimsky, Jean J. Zhao, and Thomas M. Roberts 24434 Regulation of hepatic insulin signaling and glucose homeostasis by sphingosine kinase 2 EVOLUTION Gulibositan Aji, Yu Huang, Mei Li Ng, Wei Wang, Tian Lan, Min 24359 Reconstruction of the birth of a male sex Li, Yufei Li, Qi Chen, Rui Li, Sishan Yan, Collin Tran, James G. chromosome present in Atlantic herring Burchfield, Timothy A. Couttas, Jinbiao Chen, Long Hoa Nima Rafati, Junfeng Chen, Amaury Herpin, Mats E. Chung, Da Liu, Carol Wadham, Philip J. Hogg, Xin Gao, Pettersson, Fan Han, Chungang Feng, Ola Wallerman, Mathew A. Vadas, Jennifer R. Gamble, Anthony S. Don, Pu Xia, Carl-Johan Rubin, Sandrine Pe´ron, Arianna Cocco, Ma˚rten and Yanfei Qi Larsson, Christian Tro¨tschel, Ansgar Poetsch, Kai Korsching, Wolfgang Bo¨nigk, Heinz G. Ko¨rschen, Florian Berg, Arild MICROBIOLOGY Folkvord, U. Benjamin Kaupp, Manfred Schartl, and Leif Andersson 24443 Short Vi-polysaccharide abrogates T-independent immune response and hyporesponsiveness elicited by long Vi-CRM197 conjugate vaccine GENETICS Francesca Micoli, Stefania P. Bjarnarson, Melissa Arcuri, Audur 24117 Causal inference in genetic trio studies Anna Aradottir Pind, Gudbjorg J. Magnusdottir, Francesca Stephen Bates, Matteo Sesia, Chiara Sabatti, and Emmanuel Cande`s Necchi, Roberta Di Benedetto, Martina Carducci, Fabiola Schiavo, Carlo Giannelli, Ivan Pisoni, Laura B. Martin, Giuseppe 24369 New Guinea highland wild dogs are the original Del Giudice, Calman A. MacLennan, Rino Rappuoli, Ingileif New Guinea singing dogs Jonsdottir, and Allan Saul Suriani Surbakti, Heidi G. Parker, James K. McIntyre, Hendra K. Maury, Kylie M. Cairns, Meagan Selvig, 24450 SARS-CoV-2 detection using isothermal amplification Margaretha Pangau-Adam, Apolo Safonpo, Leonardo and a rapid, inexpensive protocol for sample Numberi, Dirk Y. P. Runtuboi, Brian W. Davis, inactivation and purification and Elaine A. Ostrander Brian A. Rabe and Constance Cepko

vi u www.pnas.org Contents Downloaded by guest on September 28, 2021 24459 Multiheme hydroxylamine oxidoreductases produce PLANT BIOLOGY NO during ammonia oxidation in methanotrophs 24557 Architecture of DNA elements mediating ARF Wouter Versantvoort, Arjan Pol, Mike S. M. Jetten, Laura van Niftrik, transcription factor binding and auxin- Joachim Reimann, Boran Kartal, and Huub J. M. Op den Camp responsive gene expression in Arabidopsis 24464 Microglia depletion exacerbates demyelination and Alejandra Freire-Rios, Keita Tanaka, Isidro Crespo, Elmar van impairs remyelination in a neurotropic der Wijk, Yana Sizentsova, Victor Levitsky, Simon Lindhoud, coronavirus infection Mattia Fontana, Johannes Hohlbein, D. Roeland Boer, Victoria Mironova, and Dolf Weijers Alan Sariol, Samantha Mackin, Merri-Grace Allred, Chen Ma, Yu Zhou, Qinran Zhang, Xiufen Zou, Juan E. Abrahante, David K. Meyerholz, and Stanley Perlman 24475 Modulation of acyl-carnitines, the broad mechanism POPULATION BIOLOGY behind Wolbachia-mediated inhibition of medically 24567 Estimation of Rift Valley fever virus spillover important flaviviruses in Aedes aegypti to humans during the Mayotte Gayathri Manokaran, Heather A. Flores, Conor T. Dickson, 2018–2019 epidemic Vinod K. Narayana, Komal Kanojia, Saravanan Dayalan, Raphae¨lle Me´tras, W. John Edmunds, Chouanibou Dedreia Tull, Malcolm J. McConville, Jason M. Mackenzie, Youssouffi, Laure Dommergues, Guillaume Fournie´, Anton and Cameron P. Simmons Camacho, Sebastian Funk, Eric Cardinale, Gilles Le Godais, Soihibou Combo, Laurent Filleul, Hassani Youssouf, 24484 Nanaerobic growth enables direct visualization of and Marion Subiros dynamic cellular processes in human gut symbionts Leonor Garcı´a-Bayona, Michael J. Coyne, Noam Hantman, 24575 Local lockdowns outperform global lockdown on the Paula Montero-Llopis, Salena S. Von, Takeshi Ito, Michael H. far side of the COVID-19 epidemic curve Malamy, Marek Basler, Blanca Barquera, and Laurie E. Comstock Vadim A. Karatayev, Madhur Anand, and Chris T. Bauch 24494 Structure–function studies of Rgg binding to pheromones and target promoters reveal a model of transcription factor interplay PSYCHOLOGICAL AND COGNITIVE SCIENCES Glenn C. Capodagli, Kaitlyn M. Tylor, Jason T. Kaelber, 24581 Hierarchical structure is employed by humans during Vasileios I. Petrou, Michael J. Federle, and Matthew B. Neiditch visual motion perception Johannes Bill, Hrag Pailian, Samuel J. Gershman, NEUROSCIENCE and Jan Drugowitsch 24503 Netrin1 deficiency activates MST1 via UNC5B 24590 Goal-directed and stimulus-driven selection of receptor, promoting dopaminergic apoptosis internal representations ’ in Parkinson s disease Freek van Ede, Alexander G. Board, and Anna C. Nobre Eun Hee Ahn, Seong Su Kang, Qi Qi, Xia Liu, and Keqiang Ye 24514 Homeostatic mechanisms regulate distinct aspects of cortical circuit dynamics CORRECTIONS Yue Kris Wu, Keith B. Hengen, Gina G. Turrigiano, and Julijana Gjorgjieva BIOCHEMISTRY, CHEMISTRY 24526 Distance-dependent regulation of NMDAR 24599 Genomic analysis of siderophore β-hydroxylases nanoscale organization along hippocampal reveals divergent stereocontrol and expands neuron dendrites the condensation domain family Joana S. Ferreira, Julien P. Dupuis, Blanka Kellermayer, Nathan Zachary L. Reitz, Clifford D. Hardy, Jaewon Suk, Jean Bouvet, Be´nac, Constance Manso, Delphine Bouchet, Florian Levet, and Alison Butler Corey Butler, Jean-Baptiste Sibarita, and Laurent Groc 24534 Hair cell α9α10 nicotinic acetylcholine receptor CELL BIOLOGY functional expression regulated by ligand 24600 β-Arrestin2 is a critical component of the GPCR– binding and deafness gene products eNOS signalosome Shenyan Gu, Daniel Knowland, Jose A. Matta, Min L. O’Carroll, Songling Liu, Louis M. Luttrell, Richard T. Premont, Weston B. Davini, Madhurima Dhara, Hae-Jin Kweon, and Don C. Rockey and David S. Bredt DEVELOPMENTAL BIOLOGY PHARMACOLOGY 24601 Acrosin is essential for sperm penetration through 24165 Fifty years of capacity building in the search for new the zona pellucida in hamsters marine natural products Michiko Hirose, Arata Honda, Helena Fulka, Miwa Miguel C. Leal, Jaime M. Anaya-Rojas, Murray H. G. Munro, John W. Tamura-Nakano, Shogo Matoba, Toshiko Tomishima, Keiji Blunt, Carlos J. Melian, Ricardo Calado, and Moritz D. Lu¨rig Mochida, Ayumi Hasegawa, Kiyoshi Nagashima, Kimiko Inoue, Masato Ohtsuka, Tadashi Baba, Ryuzo Yanagimachi, PHYSIOLOGY and Atsuo Ogura 24545 Regulation of titin-based cardiac stiffness by unfolded domain oxidation (UnDOx) MICROBIOLOGY Christine M. Loescher, Martin Breitkreuz, Yong Li, Alexander 24602 Using synthetic biology to overcome barriers to Nickel, Andreas Unger, Alexander Dietl, Andreas Schmidt, stable expression of nitrogenase in Belal A. Mohamed, Sebastian Ko¨tter, Joachim P. Schmitt, Marcus eukaryotic organelles Kru¨ger, Martina Kru¨ger, Karl Toischer, Christoph Maack, Lars I. Nan Xiang, Chenyue Guo, Jiwei Liu, Hao Xu, Ray Dixon, Leichert, Nazha Hamdani, and Wolfgang A. Linke Jianguo Yang, and Yi-Ping Wang

Contents PNAS u September 29, 2020 u vol. 117 u no. 39 u vii Downloaded by guest on September 28, 2021