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Dr. Anie Y. CURRICULUM VITAE

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Dr. Anie Y. CURRICULUM VITAE Dr. Anie Y. Assistant Professor (Biochemistry) School of Biosciences, Mahatma Gandhi University, Kottayam E-mail – [email protected] . [email protected] Tel: 9947090370 CURRICULUM VITAE Date of Birth: May 5, 1980 Citizenship: Indian Address: Prakrithi Amalagiri P O Kottayam Kerala, India PROFESSIONAL EXPERIENCE • Assistant Professor : 2006 – till date, Asst. Professor in Biochemistry ,School Of Biosciences, Mahatma Gandhi University, Kottayam, 686560. • PhD : 2003-2009, Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram, Kerala, India. • UGC-JRF(NET) : 2002 • M.SC Biochemistry : 2003, School of Biociences MG University, First class, Third rank . RESEARCH INTEREST • Immunobiology Research in the lab focusses on the behaviour of immune cells like neutrophils and monocytes during metabolic diseases like Diabetes and Atherosclerosis. In addition to that, contribution of NEtosis/Etosis, a recently discovered mode of defence mechanism in both neutrophils and monocytes, on the pathogenesis of Atherosclerosis via histone citrullination is also envisaged. Hormonal influence of PAD-4 gene activity which is necessary for NETosis on disease progression is another area of interest. • Natural Product Research Plants might serve as an important source for the isolation of potential lead molecules for drug development. Likewise, some of the bacterial/fungal strains may also produce potential therapeutic molecules. In the lab, we are looking for new Aldose Reductase Inhibitor molecules from plants and fibrinolytic enzymes from microorganisms. Inhibition of the Aldose Reductase enzyme of the polyol pathway is considered efficient in delaying or preventing development of secondary diabetic complications. Thus, identification and analysis of these potentially therapeutic candidates for efficacy, cytotoxicity and mode of action is useful in developing lead molecules. So the isolation, characterization and interaction studies of these molecules with the target enzymes or molecules may provide information essential for their utilization as drugs in the management of these clinical complications or diseases. FUNDED PROJECTS SL TOPIC Year VALUE STAT FUNDING . US AGENCY N O. 1. Chemotactic response of human 2010-2012 1,24000 Finis UGC – phagocytic cells (polymorphonuclear hed MINOR leucocytes and monocytes) in RESEARC tuberculosis patients.[F.NO. H 37/599/2009(SR)] PROJECT 2. Nattokinase – fibrinolytic and anti- 2013-2014 4,73,000 Finis KSCSTE( hypertensive enzyme from novel hed YIPB) bacterialisolates. (NO.03/YIPB/KBC/2012/CSTE) 3. Immunomodulatory effect of beta – 2014-2017 13,00000 Ongo KSCSTE(B glucan on neutrophil functions in ing ack to lab Diabetes mellitus. programme (NO 1368/2014/KSCSTE) -Scientist mentor) 4. Novel aldose reductase inhibitors 2012-2016 NA Finis Project III from natural sources. hed OF DBT (No.BT/P44800/INF/22/152/2012) MSUB Interdepart mental project PUBLICATIONS Publications in journal: • Hazeena VN, Sruthi CR, Soumiya CK, Haritha VH, Jayachandran K, Anie Y . Vernonia anthelmintica (L.) Willd. Prevents Sorbitol Accumulation through Aldose Reductase Inhibition. Scholars Academic Journal of Biosciences: 4(10A); 787-795. • Surya PR, Liji L, Jayachandran K, Anie Y. Bacteria from South Indian Fermented Foods and Food- Waste Dump Sites as Sources of Fibrinolytic Enzymes. Imperial Journal of interdisciplinary research 2016: 2(7); 528- 536. • Anie Y , Sumi S, Varghese P, Madhavi L G K, Sathish M, Radhakrishnan V V. Diagnostic approaches in patients with tuberculous pleural effusion. Diagn Microbiol Infect Dis 2007: 59; 389-394.( Impact factor-2.457) Books chapter: • Y Anie , V N Hazeena, V H Haritha and V S Binchu, Multi-faceted anti-diabetic actions of aldose reductase inhibitors. Advances in Functional Foods for Human Health. (Accepted for publication on 28-10-2016). • V H Haritha, V S Binchu, V N Hazeena and Y Anie , Xylitol: A potent immunomodulator. Advances in Functional Foods for Human Health. (Accepted for publication on 28-10- 2016). • Mathai A, Sumi M G, Sumi S, Anie Y and Radhakrishnan V V, Immunology of neurotuberculosis. In Reviews in Neurology 2009 Ed Tally A B, Singh G. pg 265-294. Papers published in conference Proceedings: 1. Anie Y , Sumi S, Radhakrishnan V V. Diagnostic utility of serum IgG antibody to lipid antigens of mycobacterium tuberculosis in patients with pulmonary tuberculosis. In the proceedings of the 19th Kerala Science congress held at Kannur from 29-31 January, 2007. pp 268-269 2. Anie.Y , Sumi. S, Radhakrishnan V V. Diagnosis of tuberculous lymphadenitis – Molecular and Immunological approaches, In the proceedings of the 18th Kerala Science congress held at Thiruvananthapuram from 29-31 January, 2006. pp 471-472 3. Sumi S, Anie Y , Radhakrishnan V V, Diagnostic approaches in pleural tuberculosis. In the proceedings of the 18th Kerala Science congress held at Thiruvananthapuram from 29-31 January, 2006. pp 444-445. 4. Haritha V H, Neethi Raj P and Anie Y . Xylitol Action on impaired Neutrophil function Associated with Alcoholism. Proceedings of the National seminar on life style and Diseases. School of Biosciences, Mahatma Gandhi University. Jan 19 and 20, 2012. P. P 22-24. 5. P. Neethi Raj, V.H. Haritha and Y. Anie , Hyperglycemia and/or hyperinsulinemia conditions affect neutrophil functions indirectly, In the proceeding of Swadesi science congress 6-8 November 2012, 350-357. 6. Hazeena V.N., Jayachandran K. Suria P R and Anie Y . (2014, January 28-31) Screening and selection of Medicinal plants for aldose reductase inhibition potential of Centratherum anthelminticum. In VN Rajasekharan Pillai (Eds.), Proceedings of the 26th Kerala Science Congress. 28-31 January (pp-123-124). Wayanad, Kerala. 7. Binchu V Shaji, Neethi Raj, Haritha V H, Anie Y . (2014, November 6-8). Modulation of PMN (polymorphonuclear leukocyte) secretion and its impact on monocyte function in the presence of hyperglycemia and/or hyperinsulinemia. In Dr. R. Jayaprakash (Eds.). Proceedings. 24th swadeshi science congress. 6-8 November (pp-661-667). Thunchath Ezhuthachan Malayalam University, Tirur, Malappuram district, Kerala. 8. Surya P Rajendran, Liji L, Hazeena V. N., Jayachandran K., and Anie Y . (2014, November 6-8). Fibrinolytic enzyme production by bacillus species. In Dr. R. Jayaprakash (Eds.). Proceedings. 24th swadeshi science congress. 6-8 November (pp- 661-667). Thunchath Ezhuthachan Malayalam University, Tirur, Malappuram district, Kerala. 9. Rose Kurian and Anie Y . (2014, November 6-8). In vitro analysis of the ethyl acetate fraction of Vernonia anthelminticum . In Dr. R. Jayaprakash (Eds.). Proceedings. 24th swadeshi science congress. 6-8 November (pp-661-667). Thunchath Ezhuthachan Malayalam University, Tirur, Malappuram district, Kerala. 10. Neethi Raj P, Haritha V. H and Anie Y . (2015, January 27-29). Neutrophil extracellular trap formation during hyperglycemia. In Mara Pandiyan (Eds.), Proceedings of the 27th Kerala Science Congress. 27-29 January (pp-123-124). Alappuzha, Kerala. 11. Surya P Rajendran, Liji L, Jayachandran K., Anie Y . (2015, January 27-29). Fibrinolytic enzyme from bacillus species: culture optimisation and enzyme purification. In Mara Pandiyan (Eds.), Proceedings of the 27th Kerala Science Congress. 27-29 January (pp- 123-124). Alappuzha, Kerala. 12. Hazeena V.N., Jayachandran K. and Anie Y ., (2015, April 25). International symposium on Phytochemistry (ISP-2015), Ethyl acetate fraction of Vernonia anthelmintica: HPTLC Fingerprinting and enzyme kinetic study of the active ARI constituents, in V. Anthelmintica 13. Haritha V.H, Seena P, Anie Y , Role of monocytes in the clearance of NET (Neutrophil extracellular trap) and apoptotic bodies. In the proceedings of 28th Kerala Science Congress held at University of Calicut, Malappuram, 28- 30 January 2016, pp. 1447- 1458. 14. Hazeena V.N., Soumiya C. K., Anie Y ., Comparatitive analysis of butanol: acetonitrile and acetonitrile fractions of Vernonia anthelmintica for possible aldose reductase inhibitory constituents. In the proceedings of 28th Kerala Science Congress held at University of Calicut, Malappuram, 28- 30 January 2016, pp. 1680-1691. 15. Hazeena V.N., Haritha V. H. , Jayachandran K., Anie Y ., Ethyl acetate fraction of Vernonia anthelmintica (L.) Willd contains Aldose reductase inhibitory molecules. In the proceedings of National Seminar on Plant Science Technology for Sustainable World, 25th and 26 th February, 2016, pp. 55-59. 16. Shahana Shaji, Binchu V Shaji, Haritha V H, Anie Y . Glucose and Insulin as modulators of NETosis. In proceedings of 26 th Swadeshi Science congress held at CMFRI, Cochin, 7-9 November 2016, pp. 159-160. 17. Surya P Rajendran, Jayachadran K, Anie Y. Liposome: A novel vehicle for the administration of fibrinolytic enzymes. In proceedings of 26 th Swadeshi Science congress held at CMFRI, Cochin, 7-9 November 2016, pp. 209. FELLOWSHIPS/AWARD UGC JRF Fellowship 2002. Dr. S. S. Misra award for the best work for the year 2006-2007 by the National Academy of Medical Sciences (India), New Delhi. REFRESHER/ORIENTATION COURSES ATTENDED 1. Refresher Course in Life Sciences, UGC-Human Resource Development Center, University of Kerala, Kariavattom, 25 th Jun to 15 th jul 2015 2. Short- term course for Research Guides in Sciences, UGC-Academic Staff College, University of Kerala, Kariavattom, 5 th Nov to 9 th Nov 2012 3. Refresher course, UGC-Academic Staff College, University of Calicutt, 4 th Aug to 24 th Aug 2011. 4. Orientation Programme, UGC-Academic Staff College,
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