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PATIENTS.ANSWERS.RESULTS.

MARCH 2019 www.aruplab.com/ap Information in this brochure is current as of March 2019. All content is subject to change. Please contact ARUP Client Services at (800) 522-2787 with any questions or concerns. ARUP LABORATORIES As a nonprofit, academic institution of the University of Utah and its Department We believe in of Pathology, ARUP believes in collaborating, sharing knowledge, and contributing to laboratory science in ways that benefit our clients and their patients. collaborating,

Our test menu is one of the broadest in the industry, encompassing more sharing than 3,000 tests, including highly specialized and esoteric assays. We offer comprehensive testing in the areas of genetics, molecular , , knowledge, and and , among others. contributing ARUP’s clients include many of the nation’s university teaching to laboratory and children’s hospitals, as well as multihospital groups, major commercial laboratories, and group purchasing organizations. We do not compete with our science in ways clients for office business, choosing instead to support clients’ existing test menus by offering highly complex assays and accompanying consultative that provide support so clients can provide exceptional patient care in their local communities. the best value Offering analytics, consulting, and decision support services, ARUP provides clients with the utilization management tools necessary to prosper in this time of for the patient. value-based care. Our UM+ program helps clients control utilization, reduce costs, Together, and improve patient care. In addition, ARUP is a worldwide leader in innovative laboratory research and development, led by the efforts of the ARUP Institute for ARUP and ® Clinical and . its clients will ARUP’s reputation for quality is supported by our ability to meet or exceed the requirements of multiple regulatory and accrediting agencies and organizations. improve patient ARUP participates in the CAP laboratory accreditation program and has CLIA care today and certification through the Centers of Medicare and Medicaid Services. In December 2016, ARUP earned accreditation to the ISO 15189:2012 standard under CAP. in the future.

patients. answers. results. A laboratory test is more than a number; it is a person, an answer, a diagnosis...... TRUSTED PATHOLOGISTS ARUP’s Anatomic Pathology and Oncology Division consists of more than 30 expert pathologists, all of whom are faculty members in the Department of Pathology at the University of Utah School of . These dedicated professionals publish in peer-reviewed literature, and many serve as authors of respected pathology textbooks. These pathologists provide a full range of consultative and diagnostic services, ranging from and to .

BUILDING PROFESSIONAL RELATIONSHIPS ARUP strives to continually improve patient care by building professional relationships through excellence in pathology testing, service, education, and research. ARUP supports clients by providing services that cannot be performed at the local level due to low volume, equipment expense, or new technology. State- of-the-art technology and active research programs ensure that the most sophisticated diagnostic modalities are available.

Due to ARUP’s dual role as both a national reference laboratory and a laboratory, ARUP’s technical staff is intimately aware of the struggles faced by the community pathologist. ARUP is committed to working as a partner with community pathologists and offers services that expand their ability to serve patients.

TRUSTED PATHOLOGISTS. REPUTATION TO BE TRUSTED ARUP’s reputation for high quality is supported by its ability to meet or exceed the requirements of multiple regulatory and accrediting agencies and organizations. ARUP maintains current CLIA numbers with the U.S. Department of Health and Human Services Centers for Medicare & Medicaid Services (CMS) and is accredited by the College of American Pathologists (CAP).

INVALUABLE ANSWERS Working together with our clients expands ARUP’s ability to provide the invaluable answers needed by the medical community to make critical decisions and continually improve patient care.

RESEARCH Precise diagnoses are necessary to select the optimal form of treatment and provide prognostic information. With the advent of new technologies, the scope of research has increased considerably, allowing study of chromosomal, DNA, and protein expression abnormalities. These abnormalities are used to delineate the prognostic and therapeutic aspects of . ARUP’s Anatomic Pathology and Oncology Division continues to update its state-of-the-art service by bringing on new technologies and techniques focused on improving the accuracy of diagnosis as well as understanding disease . Research in anatomic pathology and oncology improves ARUP’s ability to diagnose disease and advances fundamental understanding of disease mechanisms.

INVALUABLE ANSWERS.™

4 For more on Anatomic Pathology, including additional technical Information, please visit: LIST OF CONSULTATIVE SPECIALTIES AND SERVICES

For a complete list of available tests in the various , refer to the ARUP Anatomic Pathology website: WWW.ARUPLAB.COM/AP

BONE AND SOFT PATHOLOGY HEAD AND NECK PATHOLOGY

BREAST PATHOLOGY

CARDIOVASCULAR PATHOLOGY HISTOCHEMICAL STAINS

CYTOPATHOLOGY

DERMATOPATHOLOGY

FISH

GASTROINTESTINAL PATHOLOGY PULMONARY PATHOLOGY

GENITOURINARY PATHOLOGY RENAL PATHOLOGY (including light microscopy, electron microscopy, and GYNECOLOGICAL PATHOLOGY immunofluorescencestudies)

ARUP’s pathologists provide a full range of consultative and diagnostic services, ranging from flow cytometry and molecular diagnostics to surgical pathology.

www.aruplab.com/ap 5 MEDICAL DIRECTORS & CONSULTING FACULTY

GENETICS GENETICS ERICA ANDERSEN, PHD BO HONG, MD, FACMG Medical Director, Cytogenetics and Medical Director, Cytogenetics and Genomic Genomic Microarray Microarray Dr. Andersen is an assistant professor of pathology at the Dr. Hong is an assistant professor of pathology at University University of Utah School of Medicine. She received her PhD of Utah School of Medicine. She received her MD at Beijing in genetics from the University of Wisconsin–Madison and Medical University in Beijing, China, and completed a completed a clinical cytogenetics at the University of in and at People’s Utah. She is board certified by the American Board of Medical Hospital, Beijing Medical University, and a clinical Genetics and Genomics and Genomics and is a fellow of the cytogenetics fellowship at the University of Utah. Her academic American College of and Genomics. Dr. interests include the clinical significance of cytogenetic findings Andersen’s interests include both constitutional and oncology cytogenetics. She is an in hematologic malignancies, particularly in pediatric active member of the Clinical Genome Resource (ClinGen) group’s efforts to improve and treatment-related leukemia. constitutional structural variant interpretation, and her oncology research projects include improving the diagnosis and monitoring for myelodysplastic syndromes and understanding the genetic etiology of rare histiocytic and dendritic .

GENETICS GENETICS PINAR BAYRAK-TOYDEMIR, MD, PHD, FACMG YUAN JI, PHD, DABCP, FACMG Medical Director, Molecular Genetics and Medical Director, Molecular Genetics and Genomics Genomics Dr. Bayrak-Toydemir is a professor of pathology at the Medical Director, Pharmacogenomics University of Utah, School of Medicine. She received her Dr. Yuan Ji is an assistant professor of pathology at the MD from the Ankara University School of Medicine in University of Utah School of Medicine. She received her PhD Ankara, Turkey, where she also received her PhD in human in molecular pharmacology and experimental therapeutics genetics. Subsequently, she completed her fellowship in at the Mayo in Rochester, Minnesota, where she clinical molecular genetics at the University of Utah. Dr. further completed her postdoctoral research fellowship in Bayrak-Toydemir is board certified in medical genetics, and pharmacogenomics. Dr. Ji is board certified in both clinical her research interests include inherited vascular disorders, specifically hereditary pharmacology and medical genetics and genomics. Dr. Ji’s major clinical and hemorrhagic telangiectasia; capillary malformation-arteriovenous malformation research focus is in pharmacogenomics, i.e., identifying novel pharmacogenomics syndrome, lymphatic , and aortopathies; and implementation of new markers and accurately testing, interpreting, and reporting pharmacogenomic technologies, such as next-generation sequencing, in clinical settings. variants.

GENETICS GENETICS HUNTER BEST, PHD, FACMG ALLEN N. LAMB, PHD, FACMG Medical Director, Molecular Genetics and Section Chief, Cytogenetics and Genomic Genomics Microarray Co-Scientific Director, NGS and Biocomputing Dr. Lamb is a professor of at the University Director, High Complexity Platforms—NGS of Utah School of Medicine. He received his PhD from Dr. Best is an associate professor of clinical pathology at the Wesleyan University in and biochemistry. University of Utah School of Medicine. He received his PhD He completed fellowships in clinical cytogenetics in the in molecular and cellular pathology at the University of North Department of Pediatrics at the University of North Carolina Carolina at Chapel Hill and completed a fellowship in clinical and in clinical molecular genetics at Harvard . molecular genetics at the Vanderbilt University in Nashville. Dr. Lamb is a founding fellow of the American College of His research focuses on the genetics of pulmonary arterial Medical Genetics and Genomics and is certified by the American Board of Medical hypertension. Genetics and Genomics in clinical cytogenetics. His primary areas of interest are in prenatal and postnatal chromosome diagnosis and the characterization of the phenotypic features (neurodevelopmental and physical development) associated with copy number changes.

GENETICS GENETICS JULIE LEANA COX, PHD, FACMG RONG MAO, MD, FACMG Medical Director, Cytogenetics Section Chief, Molecular Genetics and Genomics Dr. Cox is board certified by the American Board of Medical Genetics and Dr. Mao is an associate professor of pathology and co-director Genomics and Genomics and is a diplomate in both clinical cytogenetics and of the Clinical Medical Genetics Fellowship Program at the clinical molecular genetics. Dr. Cox received master’s degrees in human genetics University of Utah School of Medicine. She received her MD and administrative science from Johns Hopkins University and a doctorate in from Capital University of Medicine in Beijing and her MS in human genetics from the University of Maryland at Baltimore. She completed a from Beijing Union Medical College. Her clinical cytogenetics and clinical molecular genetics fellowship at the University of research interests include the genotype-phenotype correlations Maryland, Division of Human Genetics. in inborn errors of and genetic in the RAS/ MAPK pathway; she is also involved with implementing next- generation sequencing techniques into molecular diagnostics.

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GENETICS GENETICS GWENDOLYN A. MCMILLIN, PHD REHA TOYDEMIR, MD, PHD, FACMG Medical Director, Toxicology Medical Director, Cytogenetics and Genomic Co-Medical Director, Pharmacogenetics Microarray Dr. McMillin is a professor of pathology at the University Dr. Toydemir is an assistant professor of pathology at the of Utah School of Medicine. She received her PhD in University of Utah, School of Medicine. He was a fellow in pharmacology and toxicology from the University of Utah cytogenetics at ARUP Laboratories and a previous postdoctoral and is certified by the American Board of associate in the Human Genetics Department at the University in clinical chemistry and toxicological chemistry. She is a of Utah. He completed his PhD in genetics at the University member of ARUP’s R&D Executive Committee, and is actively of Utah and his MD at the University of Ankara, School of involved in professional associations such as the International Medicine in Turkey. Dr. Toydemir was the recipient of the Association of Therapeutic Drug Monitoring and Clinical Chemistry (IATDMCT), 2007 James W. Prahl Award for Outstanding Contributions by a Graduate Student the American Association for Clinical Chemistry (AACC), and the College of in the biological or biomedical science at the University of Utah, and is a member of American Pathologists (CAP).Her primary interests include detection of neonatal the American Society of Human Genetics and Turkish Society of Medical Genetics. drug exposures, pain management, and clinical applications and implementation of pharmacogenomics.

GENETICS GENETICS DENISE QUIGLEY, PHD, FACMG XINJIE XU, PHD, FACMG Medical Director, Cytogenetics Medical Director, Cytogenetics and Genomic Dr. Quigley received her PhD in molecular and medical genetics at Oregon Health Microarray Sciences University and completed post-doctoral fellowships in clinical cytogenetics Assistant Medical Director, Molecular and clinical molecular genetics at the University of North Carolina, Chapel Hill. Hematopathology/Oncology She is board certified in clinical cytogenetics and clinical molecular genetics by the Dr. Xu is an assistant professor of pathology at the University American Board of Medical Genetics and Genomics and Genomics. Dr. Quigley of Utah, School of Medicine. She received her PhD in genetics is a member of the CAP Cytogenetics Resource Committee and past-president of from the University of Wisconsin-Madison and completed a the American Cytogenetics Conference. Her research interests include integrated clinical cytogenetics fellowship at the University of Wisconsin- cytogenetic and molecular genetic testing algorithms in hematological disease for Madison and a clinical molecular genetics fellowship at Boston accurate diagnosis, prognosis, and guided . University. Dr. Xu is a fellow of the American College of Medical Genetics and Genomics and a member of several professional societies, including the American Society of Human Genetics and the American Society of Clinical Pathology. Her research interests include the identification of novel molecular markers in and the development of novel diagnostic tools for genetic testing.

GENETICS HEMATOPATHOLOGY ROGER SCHULTZ, PHD, FACMG ARCHANA MISHRA AGARWAL, MD Medical Director, Cytogenetics Medical Director, Hematopathology and Dr. Schultz received a master of science in biology at Wayne State University Special Genetics in Detroit and a PhD in genetics at Michigan State University. He completed a Dr. Agarwal is an associate professor of pathology at the postdoctoral fellowship at Stanford University School of Medicine and a cytogenetics University of Utah School of Medicine. She received her MD fellowship with subsequent American Board of Medical Genetics and Genomics at Delhi University in India and was a postdoctoral research board certification at the University of Texas Southwestern Medical Center in scholar at the University of Iowa. She served as a pathology Dallas. Dr. Schultz is a member of several professional societies, including the resident, a hematopathology fellow, and a molecular genetics American Society of Human Genetics and Association of Molecular Pathology. His pathology fellow at the University of Utah School of Medicine. research interests include chromosomal basis of human disease and development, Dr. Agarwal is board certified in hematopathology, anatomic DNA repair and cancer, and chromosome and genome stability in cancer. pathology, and clinical pathology. She is also a member of several professional societies, including the College of American Pathologists and the American Society for Clinical Pathology. Dr. Agarwal’s research interests include red-cell enzymopathies, hemoglobinopathies, and molecular hematopathology.

GENETICS HEMATOPATHOLOGY STEVEN STEINBERG, PHD, FACMG DAVID W. BAHLER, MD, PHD Medical Director, Clinical Molecular Genetics Medical Director, Hematopathology Dr. Steinberg received a PhD in biochemical genetics from Dr. Bahler is an associate professor of pathology at the the University of London and completed a fellowship in the University of Utah School of Medicine. He is certified by the Department of at Johns Hopkins University, where American Board of Pathology in clinical pathology, with an he was also an ABMGG trainee in clinical biochemical and added qualification in hematology. Dr. Bahler received his PhD molecular genetics through the Johns Hopkins Institute of in and his MD from the University of Rochester. Genetic Medicine. His research interests include exploring the His research interests include the role of antigen receptor metabolic and molecular bases of inherited disorders, improving stimulation in the development of lymphoid malignancies. diagnostic approaches to these disorders, and developing strategies for screening chemical libraries to identify candidate therapeutic molecules.

www.aruplab.com/ap 7 MEDICAL DIRECTORS & CONSULTING FACULTY

HEMATOPATHOLOGY HEMATOPATHOLOGY TRACY I. GEORGE, MD KAREN MOSER Executive Director, Clinical Trials and PharmaDx Medical Director, Hemostasis/Thrombosis Medical Director, Hematopathology Dr. Moser is an assistant professor of pathology at the University Dr. George is a professor of pathology at the University of Utah of Utah School of Medicine. She received her M.D. from School of Medicine. She completed her MD and residency Saint Louis University and subsequently served as a pathology training in anatomic pathology and laboratory medicine at resident and hematopathology fellow at the University of Utah the University of California San Francisco, with fellowships School of Medicine. She is certified by the American Board of in hematopathology and surgical pathology at Stanford Pathology in anatomic and clinical pathology, with University. Dr. George is board certified in anatomic pathology, certification in hematology. Dr. Moser is a member of several clinical pathology, and hematology by the American Board professional societies, including the College of American of Pathology. Her research interests include mast cell disease Pathologists (for which she serves as a member of the Standards and laboratory hematology. Dr. George has authored more than 100 publications, and Coagulation Resource Committees), American Society for Clinical Pathology, is Vice President of Scientific Communications for the International Society for and International Society on Thrombosis and Haemostasis. Her primary research Laboratory Hematology, and Co-Editor-in-Chief of the International Journal of interest is in laboratory hemostasis and thrombosis testing. Laboratory Hematology. She received the College of American Pathologists Lifetime Achievement Award in 2014.

HEMATOPATHOLOGY HEMATOPATHOLOGY KRISTIN HUNT KARNER, MD JAY L. PATEL, MD Medical Director, Hematopathology Medical Director, Molecular Oncology Medical Director, Molecular Oncology Medical Director, Genomics Director, Hematopathology Fellowship Program Medical Director, Hematopathology Dr. Karner is an assistant professor of pathology at the University Dr. Patel is an associate professor of pathology at the University of Utah School of Medicine. She received her MD from the of Utah School of Medicine. He received his MD from the University of Nebraska and completed her anatomic and clinical University of Arizona and completed a residency in anatomic pathology residency at the University of New Mexico. She also and clinical pathology at the University of Utah. Dr. Patel then completed hematopathology and molecular genetic pathology served as a hematopathology fellow at Stanford University. He is fellowships at the University of New Mexico and is board certified certified by the American Board of Pathology in anatomic and by the American Board of Pathology in anatomic and clinical clinical pathology, with subspecialty boards in hematology, and is a member of the pathology (AP/CP), as well as hematopathology and molecular genetic pathology. CAP Hematology & Clinical Microscopy Resource Committee. Dr. Patel’s clinical Dr. Karner’s areas of focus include both lymphoid and myeloid malignancies, and her current research interests include genetic aspects of and and research interests are broad and include all aspects of hematopathology. He is other myeloid malignancies. keen on application of next-generation sequencing technologies in the diagnosis and prognostication of hematolymphoid malignancies and benign hematologic disorders.

HEMATOPATHOLOGY HEMATOPATHOLOGY K. DAVID LI, MD SHERRIE L. PERKINS, MD, PHD Medical Director, Hematopathology CEO, ARUP Laboratories Assistant Medical Director, Hematologic Flow Dr. Perkins, CEO of ARUP Laboratories and a professor of Cytometry pathology at the University of Utah School of Medicine, has Dr. Li is an assistant professor of pathology at the University of been with ARUP and the University of Utah for over 25 years Utah School of Medicine. He received his MD from New York and has served in numerous leadership roles. She is board Medical College and completed a residency in anatomic and certified in anatomic pathology and holds a special qualification clinical pathology at the University of California, San Diego. in hematology. She has authored over 200 peer-reviewed Dr. Li also completed a fellowship in hematopathology at the journal articles and 70 book chapters in hematopathology. University of Utah, and is board certified by the American She received her PhD in biochemistry from the University of Board of Pathology in anatomic and clinical pathology, with subspecialty boards in Miami, and earned her MD and completed her pathology residency at Washington hematology. University in St. Louis. She completed her hematopathology fellowship under Dr. Carl Kjeldsberg at the University of Utah.

HEMATOPATHOLOGY HEMATOPATHOLOGY RODNEY R. MILES, MD, PHD ANTON RETS Section Chief, Hematopathology Medical Director, Hematopathology Dr. Miles is an associate professor of pathology at the University Dr. Rets is an assistant professor of pathology at the University of Utah School of Medicine. He received his MD and a of Utah School of Medicine. He received his MD and PhD PhD in from the University of Nebraska and is at Perm State Academy of Medicine in Russia. He served certified by the American Board of Pathology in anatomic as an anatomical and clinical pathology resident at State and clinical pathology, with subspecialty certification in University of New York Health Science Center at Brooklyn hematology. His research interests include biological subtypes and a hematopathology fellow at the University of Utah School of adult and pediatric non-Hodgkin . Dr. Miles is of Medicine. Dr. Rets is board certified in hematopathology, a member the American Society of Hematology, the Society anatomic pathology, and clinical pathology. He is also a member for Hematopathology, and the United States and Canadian of several professional societies, including the College of American Pathologists and Academy of Pathology. the American Society for Clinical Pathology. Dr. Rets’ professional interests are broad and include red cell disorders, non-neoplastic hematology, and precursor lymphoid neoplasms.

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HEMATOPATHOLOGY SURGICAL PATHOLOGY/SOLID TUMOR GEORGE M. RODGERS III, MD, PHD DANIEL ALBERTSON, MD Medical Director, Hemostasis/Thrombosis Medical Director, Surgical Pathology and Oncology Dr. Rodgers is a professor of medicine and pathology at the Section Head, Surgical Pathology University of Utah School of Medicine. He received his PhD Director, Genitourinary Pathology in pharmacology and his MD from the Tulane University Dr. Albertson is an assistant professor of pathology at the School of Medicine and is certified in internal medicine by the University of Utah School of Medicine. He received his MD American Board of Internal Medicine and in hematology by the from the University of Nebraska and completed his residency American Board of Pathology. Dr. Rodgers is the co-editor of in anatomic and clinical pathology at Creighton University, Wintrobe’s Clinical Hematology. followed by a surgical pathology fellowship at the University of Utah. While at Creighton, Dr. Albertson served as the chief resident for two years and received the Hal Lankford Pathology Resident Award. He is a member of United States and Canadian Academy of Pathology and the College of American Pathologists. Dr. Albertson’s special research interests include oncologic genitourinary pathology.

HEMATOPATHOLOGY SURGICAL PATHOLOGY/SOLID TUMOR KRISTI J. SMOCK, MD PHILIP S. BERNARD, MD Medical Director, Hemostasis/Thrombosis Medical Director, Molecular Oncology Dr. Smock is an associate professor of pathology and associate Dr. Bernard is a professor of pathology at the University of program director of the Pathology Residency Program at Utah School of Medicine. He received his MD from and the University of Utah School of Medicine. She completed completed his postdoctoral training at the University of Utah her , residency, and fellowship training at the and is certified in clinical pathology by the American Board of University of Utah. She is currently vice president of the North Pathology. Dr. Bernard’s laboratory at the Huntsman Cancer American Specialized Coagulation Laboratory Association Center utilizes comprehensive genomic analyses to identify and (NASCOLA) and an editorial board member for Research and translate biomarkers into clinical care for cancer patients. His Practice in Thrombosis and Haemostasis. Dr. Smock’s primary work in gene expression classification of cancer led to the research interest is laboratory coagulation medicine. development of PAM50 (Prosigna), an FDA-approved diagnostic offered worldwide. His current research are in the development of liquid biopsies using ctDNA, CTCs, and exosomes for monitoring and early detection of cancer.

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR KAJSA AFFOLTER, MD MARY BRONNER, MD Medical Director, Anatomic Pathology Co-Division Chief, Anatomic and Molecular Dr. Affolter is an associate professor of pathology at the Oncologic Pathology University of Utah School of Medicine. She received her Medical Director, Biocomputing MD from the University of Kansas School of Medicine while Dr. Bronner is a Carl R. Kjeldsberg presidential endowed completing her residency in anatomic and clinical pathology professor of pathology at the University of Utah School and fellowship in gastrointestinal, hepatic, and pancreatic of Medicine. She received her MD from the University of biliary pathology at the University of Utah School of Medicine. Pennsylvania and completed her pathology residency training She is certified by the American Board of Pathology in anatomic and chief residency at the Hospital of the University of and clinical pathology and is a member of the United States and Pennsylvania. Dr. Bronner’s honors include her election as Canadian Academy of Pathology, American Society for Clinical Pathology, College president of the GI Pathology Society and the award of the Arthur Purdy Stout Prize, of American Pathologists, and the Gastrointestinal Pathology Society, among recognizing her work as a surgical pathologist under the age of 45. other professional organizations. Dr. Affolter has research interests that include the serrated pathway of colorectal and predictive markers in inflammatory bowel disease.

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR MOUIED ALASHARI, MD BARBARA E. CHADWICK, MD Pediatric Pathologist Medical Director, Cytology Dr. Alashari is an associate professor of pathology at the Dr. Chadwick is an associate professor of anatomic pathology University of Utah School of Medicine. He received his MD at the University of Utah School of Medicine. She received from Baghdad University College of Medicine, and completed her MD at Loma Linda University in California where she residencies in anatomic pathology and general at also served as a pathology fellow. Dr. Chadwick completed her New York Medical College, a clinical pathology residency at residency in anatomic and clinical pathology at the University Yale University, and a pediatric pathology fellowship at the of Utah School of Medicine and was a fellow at Children’s Hospital of Pittsburgh. He is board certified by the University of Washington in Seattle. She is a member of the the American Board of Pathology in anatomic and clinical United States and Canadian Academy of Pathology, American pathology and pediatric pathology. Dr. Alashari is a member of several professional Society of Cytopathology, and College of American Pathologists. Dr. Chadwick’s societies, including the Society for Pediatric Pathology, the American Society of research interests include the use of molecular markers in cytopathology, pancreatic Clinical Pathologists, and the College of American Pathologists. and biliary cancer, and screening.

www.aruplab.com/ap 9 MEDICAL DIRECTORS & CONSULTING FACULTY

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR FREDERIC CLAYTON, MD LYSKA L. EMERSON, MD Medical Director, Service Medical Director, Gross Dissection Lab, Huntsman Dr. Clayton is a professor of pathology and director of the Hospital; Staff Pathologist, Anatomic Pathology autopsy service at the University of Utah School of Medicine. Dr. Emerson is an associate professor of pathology at the He received his MD from Washington University in St. Louis, University of Utah School of Medicine. She received her and completed postgraduate training in anatomic pathology at MD from the University of Texas Health Sciences Center at Stanford and clinical pathology at the University of Utah. He Houston and served a residency in pathology at the University has interests in inflammatory diseases of the alimentary tract, of New Mexico Health Sciences Center and the University other eosinophilic disorders, and medical student teaching. of Texas Health Sciences Center. Dr. Emerson completed her fellowship in general surgical pathology at the University of Utah Hospitals and and is certified by the American Board of Pathology in anatomic pathology. She is a member of the United States and Canadian Academy of Pathology, American Society for Clinical Pathology (fellow), and the Huntsman- Intermountain Cancer Care Program. Dr. Emerson’s current research interests include molecular characterization of the initiating mutations in cancer.

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR JOSHUA F. COLEMAN, MD KIMBERLEY J. EVASON, MD, PHD Medical Director, Molecular Oncology Medical Director, Anatomic Pathology Dr. Coleman is an assistant professor of pathology at the Dr. Evason is an assistant professor at the University of Utah University of Utah School of Medicine. He earned his MD at School of Medicine and an investigator in the Department Case Western Reserve University School of Medicine in 2007. of Oncological Sciences at the Huntsman Cancer Institute. Dr. Coleman subsequently completed his residency in anatomic She received her MD and PhD through the Medical Scientist and clinical pathology at the Cleveland Clinic (2011), followed Training Program at Washington University in St. Louis. by fellowships in hematopathology and molecular genetic She served a residency and completed fellowship training in pathology. He is board certified in molecular genetic pathology, anatomic and liver/gastrointestinal pathology at the University hematopathology, and anatomic and clinical pathology, of California at San Francisco, followed by a post-doctoral practicing most recently at the Ohio State University (2013–16). Immediately fellowship mentored by Didier Stainier, Andrei Goga, and J. Michael Bishop. Dr. prior to joining the University of Utah, Dr. Coleman served as the vice president of Evason’s research and clinical interests are centered on gastrointestinal and liver medical affairs with GenomOnocology, LLC, in Cleveland, Ohio. pathology, with a specific focus on hepatocellular . She is currently investigating molecular pathways and identifying drugs that influence liver tumorigenesis.

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR JESSICA COMSTOCK, MD RACHEL E. FACTOR, MD, MHS Pediatric Pathologist Medical Director, Anatomic Pathology and Dr. Comstock is the director of autopsy at Primary Children’s Cytology Hospital and an associate professor of pathology at the Dr. Factor is an associate professor of pathology, director University of Utah School of Medicine. She received her MD of breast pathology, and co-director of the Cytopathology from the University of Iowa and completed both a pathology Fellowship Program at the University of Utah School of residency and a pediatric pathology fellowship at the University Medicine. She received her master of health science from Johns of Utah. She is board certified in anatomic and clinical Hopkins School of and her MD from the Albert pathology with a sub-certification in pediatric pathology. Einstein College of Medicine in Bronx, New York, followed by Dr. Comstock is a member of several professional societies, residency and fellowships at Brigham and Women’s Hospital in including the Society of Pediatric Pathology, College of American Pathologists, and Boston. Dr. Factor is board certified in anatomic pathology and cytopathology, and the American Society of Clinical Pathologists. is a member of the College of American Pathology, the United States and Canadian Academy of Pathology, and the American Society for Clinical Pathology. Her research interests include the biology and prevention of breast cancer.

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR GEORGIOS DEFTEREOS, MD LARISSA V. FURTADO, MD Medical Director, Molecular Oncology Medical Director, Molecular Oncology Section Head, Molecular Oncology Dr. Furtado is an assistant professor of pathology at the Dr. Deftereos is an assistant professor of pathology at the University of Utah School of Medicine. She completed her University of Utah School of Medicine. He received his MD residency in anatomic and clinical pathology at the University from the University of Bari Aldo Moro in Italy. Prior to of Utah and ARUP Laboratories, where she was chief resident, his pathology training, Dr. Deftereos completed a research and her molecular genetic pathology fellowship at the University fellowship focusing on HPV and gynecological malignancies of Michigan. Prior to joining ARUP as a medical director, Dr. at the University of Washington. His residency was in Furtado co-founded the Division of Genomic and Molecular anatomic and clinical pathology. Dr. Deftereos is board Pathology at the University of Chicago, where she worked as an certified in anatomic pathology, clinical pathology, cytopathology, and molecular assistant professor of pathology and was the co-director of the University of Chicago genetic pathology, and provides service in the areas of molecular oncology and Clinical Genomics and Molecular Diagnostics Laboratories. Dr. Furtado’s research cytopathology. His research interests include epigenetics of solid tumors and interests include genomic diagnostics in solid tumors and molecular diagnostic minimally invasive precision diagnostics, with emphasis on the use of molecular methods in oncology. testing in cytopathology of solid tumors.

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SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR EVELYN V. GOPEZ, MD JOLANTA JEDRZKIEWICZ, MD Medical Director, Cytology Medical Director, Anatomic Pathology Dr. Gopez is a professor of pathology and associate dean in Dr. Jedrzkiewicz is an assistant professor of pathology at the the Office of Inclusion and Outreach at the University of Utah University of Utah School of Medicine. She obtained her School of Medicine. She received her MD at the University MD from Poznan University of Medical Sciences in Poland. of Santo Tomas in Manila, Philippines, and completed her She completed her anatomic and clinical pathology residency residency in anatomic and clinical pathology at the Berkshire at the University of Utah, followed by an oncologic surgical Medical Center in Pittsfield, Massachusetts. She also completed pathology fellowship at the MD Anderson Cancer Center in a fellowship in cytopathology and surgical pathology at Houston and a gastrointestinal fellowship at the Mount Saini the University of Pennsylvania and is board certified in Hospital in Toronto. She is certified by the American Board of cytopathology, as well as anatomic and clinical pathology. For Pathology in anatomic and clinical pathology and is a member of United States and seven years, Dr. Gopez served as residency program director at the University of Canadian Academy of Pathology, as well as the College of American Pathologists. Utah Department of Pathology. She assists ARUP’s clients by signing out specimen Dr. Jedrzkiewicz has research interests in oncologic gastrointestinal pathology and cases while also teaching residents and fellows in training. appendiceal neoplasms.

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR ALLIE GROSSMANN, MD, PHD NEELIMA KANDULA, MD Medical Director, Surgical Pathology and Molecular Medical Director, Surgical Pathology Oncology Dr. Kandula is an assistant professor of pathology at the University of Utah School Dr. Grossmann received a BS in zoology at the College of of Medicine. She received her MD from the NTR University of Health Sciences, Idaho and a PhD and MD from the Oregon Health Sciences Guntur Medical College in Guntur, India. She completed her residency in anatomic University, where she studied tyrosine kinase substrate and clinical pathology at the Creighton University, followed by a cytopathology specificity with Brian J. Druker, MD. Dr. Grossmann completed fellowship at the University of Utah. While at Creighton, Dr. Kandula served as both a residency in anatomic pathology and a research the chief resident. She is certified by the American Board of Pathology in anatomic fellowship in at the University of Utah. Her and clinical pathology and cytopathology. She is a member of the United States postdoctoral work in the laboratory of Dean Y. Li,MD, PhD, and Canadian Academy of Pathology, College of American Pathologists, American focused on the role of small GTPases in melanoma invasion and metastasis. Most Society of Cytopathology, and International Society of Urological Pathology. Dr. recently, Dr. Grossmann completed a fellowship in molecular genetic pathology at Kandula has subspecialty interests in cytopathology, genitourinary pathology, and ARUP Laboratories. Her primary subspecialty interests are sarcoma pathology and their related research. molecular oncology. Her research interests include mechanisms of tumorgenesis, metastasis, and the development of targeted for cancer treatment.

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR H. EVIN GULBAHCE, MD TING LIU, MD Medical Director, Surgical Pathology and Oncology Director, Surgical Pathology Dr. Gulbahce is a professor of pathology at the University of Dr. Liu is an associate professor of surgical pathology at the Utah School of Medicine. She received her MD from Hacettepe University of Utah School of Medicine and Surgical Pathology University in Ankara, Turkey, and completed a residency in director at the University of Utah Department of Pathology. anatomic and clinical pathology and a surgical pathology Dr. Liu received her MD from Beijing University of Chinese fellowship at the University of Minnesota. Her research interests Medicine and her MS in pathophysiology from Peking Union include pulmonary complications of solid organs, hematopoietic Medical College. She completed AP/CP residency training stem cell transplantation, and breast cancer risk factors, at Drexel University College of Medicine, a fellowship in specifically risk factor for basal-like and triple negative . hematology at Drexel University College of Medicine, and an oncologic/surgical fellowship at Memorial Sloan-Kettering Cancer Center. Dr. Liu is an AP/CP and hematopathology-boarded pathologist. Her current research interests include oncologic clinical research.

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR ELKE JARBOE, MD AMY LOWICHIK, MD, PHD Medical Director, Surgical Pathology and Staff Pathologist, Pediatric Pathology Cytopathology Dr. Lowichik is clinical professor of pediatric pathology at the University of Utah Dr. Jarboe is an associate professor of pathology at the School of Medicine. She is also the director of Autopsy Service and Anatomic University of Utah School of Medicine. She received her MD Pathology at Primary Children’s Medical Center and the associate chief of the from and completed her anatomic pathology residency training Division of Pediatric Pathology at the University of Utah School of Medicine. Dr. at the University of Colorado School of Medicine. Subsequently, Lowichik received her PhD in zoology and microbiology at Tulane University and she completed fellowships in women’s and perinatal pathology her MD at the University of Michigan in Ann Arbor. She served as a pediatrics and cytopathology at Brigham and Women’s Hospital in resident at the Children’s Medical Center of Dallas and a pediatric pathology fellow Boston. Her primary subspecialty and research interest is at the University of Texas Southwestern Medical School. Dr. Lowichik is board in gynecologic pathology. Dr. Jarboe is a member of the editorial board for the certified in pediatric pathology, clinical pathology, and anatomic pathology, and is International Journal of Gynecological Pathology and the cytopathology section editor a member of the Society for Pediatric Pathology. Dr. Lowichik’s research interests for the American Journal of Clinical Pathology. include pediatric gastrointestinal pathology and .

www.aruplab.com/ap 11 MEDICAL DIRECTORS & CONSULTING FACULTY

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR ANNA P. MATYNIA, MD MONICA PATRICIA REVELO, MD, PHD Medical Director, Solid Tumor Molecular Medical Director, Renal Pathology Diagnostics Dr. Revelo is an associate professor of pathology at the Dr. Matynia is an assistant professor of pathology at the University of Utah School of Medicine. She received her MD University of Utah School of Medicine. She received her MD from the Central University of Ecuador School of Medicine from the Jagiellonian University in Kraków, Poland, and and her PhD in pathology from the Federal University of completed her residency in pathology, as well as fellowships Minas Gerais in Brazil. Dr. Revelo completed a fellowship in in hematopathology and molecular genetic pathology, at the renal pathology at Vanderbilt University Medical Center and University of Utah and ARUP Laboratories. Dr. Matynia is is certified by the American Board of Pathology. Her research certified by the American Board of Pathology in anatomic and interests include mechanisms of chronic allograft and antibody clinical pathology, with subspecialty certification in hematology and molecular mediated-rejection in kidney, heart, and pancreas transplants, mechanisms of genetic pathology. Her academic interests include molecular diagnostics of glomerular diseases and molecular mechanisms of prostate carcinoma development hematolymphoid and solid tumor malignancies. and progression.

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR CHERYL ANN PALMER, MD WADE SAMOWITZ, MD Medical Director, Neuropathology Medical Director, Solid Tumor Molecular Dr. Palmer is a professor of pathology and the director of the Diagnostics and Histology Pathology Residency Program at the University of Utah School Staff Pathologist, Anatomic Pathology of Medicine. She received her MD at West Virginia University Dr. Samowitz is a professor of pathology at the University of and served as a resident in neurology and postdoctoral fellow Utah School of Medicine. He received his MD from SUNY in neuropathology at the University of Utah, where she also Downstate, and completed residency training in anatomic completed internships in internal medicine and pathology. She pathology at the University of Chicago and fellowships is a fellow of the American Academy of Neurology, recently in gastrointestinal pathology at Johns Hopkins Hospital. served as the vice-president of the American Association of Specializing in gastrointestinal pathology and the molecular Neuropathologists, and sits on the editorial board of Case Reports in Pathology. genetics of colorectal cancer, Dr. Samowitz is also the medical director for numerous Dr. Palmer’s research interests include neuropathological parameters of epilepsy, molecular tests in solid tumor molecular diagnostics, including single-gene assays relationships between histologic and molecular genetic findings in brain tumors, and and next-generation sequencing panels. pediatric neuropathology, with special emphasis on epileptogenic disorders and brain tumors.

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR MARIA PLETNEVA, MD, PHD JOHANNA SAVAGE, MD Surgical Pathology Resident Rotation Director, Medical Director, Anatomic Pathology University of Utah School of Medicine Dr. Savage is an assistant professor of pathology at the University Dr. Pletneva is an assistant professor of pathology at the of Utah School of Medicine. She received her MD from the University of Utah School of Medicine. She completed the University of Iowa Carver College of Medicine and completed Medical Scientist Training Program and earned her MD a residency in anatomic and clinical pathology, as well as a and PhD degrees from Johns Hopkins University School of surgical pathology fellowship, at the University of Iowa Hospitals Medicine. She completed residency in anatomic and clinical and Clinics. She subsequently went on to complete a two-year pathology, as well as fellowships in hematopathology and fellowship/junior faculty position in gynecologic pathology at The surgical pathology with concentration in gastrointestinal Johns Hopkins Hospital in Baltimore, Maryland. Dr. Savage is pathology at University of Michigan. Her research interests include improvement of board certified by the American Board of Pathology and is a fellow of the College of diagnostic tools for graft-versus-host disease and novel diagnostic approaches and American Pathologists and the American Society of Clinical Pathology. predictive factors for lymphoproliferative neoplasms.

SURGICAL PATHOLOGY/SOLID TUMOR SURGICAL PATHOLOGY/SOLID TUMOR THEODORE J. PYSHER, MD DEEPIKA SIROHI, MD Chief, Pediatric Pathology and Electron Microscopy Medical Director, Molecular Oncology Dr. Pysher is an adjunct professor of pathology, adjunct professor Dr. Deepika Sirohi is an assistant professor of pathology at the of pediatrics, and chief of the Division of Pediatric Pathology at University of Utah School of Medicine. She received her MD the University of Utah School of Medicine. He is also the head from Armed Forces Medical College in Prune, Maharashtra, of Pathology and Director of Laboratories at Primary Children’s India and went on to complete her residency in anatomical Hospital. Dr. Pysher received his MD from the University of and clinical pathology at University of Texas Health Science Chicago, trained in Anatomic and Clinical Pathology at Cleveland Center at San Antonio where she served as Co-chief Resident. Metropolitan General (CMGH) and in pediatrics at CMGH Dr. Sirohi completed fellowship programs in Genitourinary and Rainbow Babies and Children’s Hospital in Cleveland, and Pathology at Cedar-Sinai Medical Center and Molecular was a Pediatric Pathology fellow at Children’s Hospital of Los Angeles. He is a former Genetic Pathology at the University of California San Francisco. She is board president of the Society for Pediatric Pathology, member of the Pediatric Pathology Test certified by the American Board of Pathology in Anatomical and Clinical Pathology. Development and Advisory Committee of the American Board of Pathology and the Her research interests include genomic alterations in urologic malignancies, viral editorial board for Pediatric and Developmental Pathology. Dr. Pysher’s research interests oncogenesis and application of next generation sequencing to solid tumors. include hemolytic uremic syndrome and pediatric laboratory test utilization.

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SURGICAL PATHOLOGY/SOLID TUMOR JOSHUA A. SONNEN, MD Medical Director, Anatomic Pathology, Oncology, and Neuropathology Dr. Sonnen is an associate professor of pathology at the University of Utah School of Medicine. He received his MD from the Keck School of Medicine, University of Southern California, completing his residency at the University of Arizona, Tucson, and his neuropathology fellowship at the University of Washington, Seattle. He is a member of the College of American Pathologists and American Association of Neuropathologists. Dr. Sonnen’s research interests dementia, Alzheimer disease, chronic traumatic encephalopathy, and other neurodegenerative diseases.

SURGICAL PATHOLOGY/SOLID TUMOR BRYAN TRUMP, DDS, MS Medical Director, Anatomic Pathology Dr. Trump is an assistant professor at the University of Utah School of , as well as an adjunct professor of anatomic pathology at the University of Utah School of Medicine. He received his DDS from Virginia Commonwealth University School of Dentistry, and completed his oral and maxillofacial pathology residency as well as a master’s in at Texas A&M University Baylor College of Dentistry. He is board certified in oral and maxillofacial pathology. His research interests include head and neck pathology, with a focus on Sjögren’s syndrome, salivary gland neoplasms, and oral squamous cell carcinoma. Dr. Trump is a member of the American Academy of Oral & Maxillofacial Pathology, North American Society of Pathology, American Dental Association, American Dental Education Association, Utah Dental Association, and Salt Lake County Dental Society.

SURGICAL PATHOLOGY/SOLID TUMOR BENJAMIN L. WITT, MD Medical Director, Cytopathology Dr. Witt is an assistant professor of anatomic pathology at the University of Utah School of Medicine, where he serves as the residency rotation director for cytopathology. Dr. Witt received his MD at the University of Colorado Denver, School of Medicine and completed his AP/CP pathology residency at the University of Chicago (NorthShore) where he served as the chief resident during his last two years. He also completed a cytopathology fellowship at the University of Utah/ARUP Laboratories, and is board certified in anatomic and clinical pathology, with subspecialty boards in cytopathology. Dr. Witt is a member of the College of American Pathologists Cytopathology Committee, the American Society for Clinical Pathology, and the American Society of Cytopathologists. His research interests include studies related to fine-needle aspiration and head and neck pathology.

SURGICAL PATHOLOGY/SOLID TUMOR HOLLY ZHOU, MD, MS Pediatric Pathologist Dr. Zhou is an associate professor of pathology at the University of Utah School of Medicine. She received her medical degree from Fujian Medical College of China, where she also completed an MS in . Subsequently, Dr. Zhou completed a research fellowship in endocrinology at the University of Maine, and both an AP/CP residency and a pediatric pathology fellowship at New York University. She is board certified by the American Board of Pathology in both anatomic and clinical pathology and pediatric pathology. Dr. Zhou is a member of the United States and Canadian Academy of Pathology and the Society for Pediatric Pathology. Her research interests include pediatric bone and soft tissue tumors.

www.aruplab.com/ap 13 ANATOMIC PATHOLOGY LABORATORIES

CYTOPATHOLOGY The ARUP Cytopathology Laboratory is a full-service laboratory providing screening and diagnostic testing on gynecological, non- gynecological, and fine-needle aspiration specimens. Consultation for difficult gynecologic, non-gynecologic, and fine-needle aspiration biopsy specimens is available from ARUP’s board- certified cytopathologists. By offering molecular testing, such as UroVysion FISH testing for urine and pancreatobiliary specimens, the Cytopathology Laboratory can assist clients in broadening their scope of services.

HEMATOLOGIC FLOW CYTOMETRY The ARUP Hematologic Flow Cytometry Laboratory performs leukemia and phenotyping with interpretations based on five-color analysis of multiple antigens. Using fluorescently labeled antibodies, surface markers in leukemia and lymphoma aid in identifying the tumor lineage, which provides diagnostic and prognostic information. This laboratory also performs circulating tumor cell analysis for prostate, breast, and colon tumor monitoring.

HEMATOPATHOLOGY The Hematopathology Laboratory and the Division of Hematopathology offer diagnostic consultative services and a comprehensive testing menu for the evaluation of hematologic disorders. The Division of Hematopathology consists of nationally and internationally known experts whose expertise spans many different subspecialties of hematopathology, including flow cytometry, immunohistochemistry, cytogenetics, coagulation, and molecular diagnostics. An integrated approach is utilized to provide clients with services ranging from test interpretation and selection to a comprehensive histomorphologic diagnosis.

IMMUNOHISTOCHEMISTRY The ARUP Immunohistochemistry Laboratory performs more than 175 stains on formalin-fixed, paraffin-embedded tissues/cellblocks. These stains are used to detect the presence, abundance, and localization of specific proteins to aid in determining the direction of differentiation in neoplasms with similar morphology, as well as to provide prognostic or therapeutic information, among other applications.

This lab is pathologist oriented, providing a stain and return service only, without interpretation, to our client pathologists to assist in their diagnostic studies. Most stains are returned the next day.

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MOLECULAR ONCOLOGY The ARUP Molecular Oncology Laboratory offers a broad hematologic and soft/solid tumor menu, as well as consultative services in oncology. Testing is designed to aid the physician in answering important clinical questions in the areas of screening, prognosis, treatment, and monitoring. An active research program in the ARUP Institute for Clinical and Experimental Pathology is committed to developing molecular technologies that will ensure continued quality of clinical testing in the rapidly progressing field of molecular pathology.

SURGICAL PATHOLOGY Surgical Pathology is staffed by full-time University of Utah School of Medicine faculty. The faculty’s expertise in a wide variety of specialties enables the department to support ARUP’s clients throughout the United States and to aid the University of Utah Health Sciences Center and the Huntsman Cancer Hospital in their role as premier healthcare providers and teaching facilities for the region.

The department’s specialties include, but are not limited to: bone and soft tissue pathology, breast pathology, genitourinary pathology, gastrointestinal pathology, head and neck pathology, renal pathology, and neuropathology. Consultative and diagnostic services are available. Department services include gross dissection, frozen-section techniques, routine histology, rapid tissue processing, special stains and immunohistochemical , and patient reporting, with access to a wide variety of ancillary techniques, including electron microscopy and molecular diagnostics.

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ARUP LABORATORIES 500 Chipeta Way Salt Lake City, UT 84108-1221 Phone: (800) 522-2787 Fax: (801) 583-2712 www.aruplab.com

ARUP is a nonprofit enterprise of the University of Utah and its Department of Pathology. © 2019 ARUP Laboratories BD-TS-001, Rev 17, March 2019