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Perioperative Opioid-Sparing Analgesia Strategies for Enhanced Recovery After Surgery
Perioperative Opioid-Sparing Analgesia Strategies for Enhanced Recovery After Surgery T. Anthony Anderson, MD PhD Associate Professor Department of Anesthesiology, Perioperative and Pain Medicine Lucile Packard Children's Hospital Stanford Stanford University School of Medicine International Society for Anaesthetic Pharmacology 2018 Annual Meeting Disclosures • I have no relevant relationships to disclose Learning Objectives After this lecture, the listener should be able to: • Identify risks associated with the perioperative use of opioids • Determine opioid-sparing systemic pharmacologic analgesics options • Organize a perioperative analgesic plan to decrease postoperative pain, reduce opioid use, hasten recovery, and improve patient safety Paradigm Shift Surgical Considerations Optimize Co-Morbidities Baseline Pain & Opioid Use Regional techniques Non-pharmacologic Non-opioid Opioids Reasons to Reduce Peri-operative Opioid Use • Relapse risk in patients with a history of opioid use disorder • Improved post-operative recovery • Acute risks • Chronic risks Opioid Use Disorder Relapse • In 2016, 1.8 million people had prescription pain medication use disorder, 5.5% of population • High risk group • Poor evidence for pain management options • Perioperative exposure to relapse triggers: – Stress – Agent of abuse Ward EN, Quaye AN, Wilens TE. Opioid Use Disorders: Perioperative Management of a Special Population. Anesth Analg. 2018 Aug;127(2):539-547. Briand LA, Blendy JA. Molecular and genetic substrates linking stress and addiction. Brain Res. 2010 Feb 16;1314:219-34. ERAS Colorectal Surgery • 13 major perioperative categories • 3 rely heavily on opioid reduction – Multimodal, opioid-sparing pain management – PONV prevention – Ileus reduction • ERAS protocols reduce – Length of hospital stay – Costs – Minor complications Carmichael JC, Keller DS, Baldini G, Bordeianou L, Weiss E, Lee L, Boutros M, McClane J, Feldman LS, Steele SR. -
Original Article Anesthetic Effect of Propofol Combined with Remifentanil and Propofol Combined with Ketamine in Ophthalmic Surgery
Int J Clin Exp Med 2019;12(7):9387-9392 www.ijcem.com /ISSN:1940-5901/IJCEM0079428 Original Article Anesthetic effect of propofol combined with remifentanil and propofol combined with ketamine in ophthalmic surgery Xiaofeng Yi1*, Yanbing Zhang1*, Limin Jin1, Xinjing Yang2 Departments of 1Anesthesia Surgery, 2Emergency ICU, First Affiliated Hospital of Soochow University, Suzhou 215000, Jiangsu, China. *Equal contributors. Received May 10, 2018; Accepted December 7, 2018; Epub July 15, 2019; Published July 30, 2019 Abstract: Propofol combined with ketamine has been used for anesthesia in the past. Remifentanil presented a good analgesic effect, rapid onset, short half-life, and a high clearance rate. Propofol combined with remifentanil also shows good effects in the clinic. This study compared the effect and safety of propofol combined remifentanil and propofol combined ketamine in pediatric eye surgery. Pediatric patients that received eye surgery in our hospital were selected and randomly divided into two groups, the experimental group (n=30), in which patients received pro- pofol combined with remifentanil anesthesia and control group (n=30), and the group receiving propofol combined with ketamine anesthesia. The curative effect, FCO2, SPO2, MAP, HR, anesthesia complications, operation time, recovery time, and leaving PACU time were compared. The rate of good anesthesia was 93.33% in the experimental group, which was significantly higher than control (P < 0.05). FCO2 at 2 and 5 minutes after anesthesia, preopera- tive, intraoperative, and postoperative elevated, while SPO2, MAP, and HR decreased (P < 0.05). The experimen- tal group showed smaller fluctuation range than the control. The rate of Nausea (6.67%), vomiting (3.33%), and somnolence (10%) in the experimental group was significantly lower than control (P < 0.05). -
Federal Register/Vol. 85, No. 36/Monday, February 24, 2020
10466 Federal Register / Vol. 85, No. 36 / Monday, February 24, 2020 / Notices Controlled substance Drug code Schedule Alphamethadol ................................................................................................................................................................. 9605 I Benzethidine .................................................................................................................................................................... 9606 I Betacetylmethadol ........................................................................................................................................................... 9607 I Clonitazene ...................................................................................................................................................................... 9612 I Diampromide ................................................................................................................................................................... 9615 I Diethylthiambutene .......................................................................................................................................................... 9616 I Dimethylthiambutene ....................................................................................................................................................... 9619 I Ketobemidone ................................................................................................................................................................. -
ESTIMATED WORLD REQUIREMENTS of NARCOTIC DRUGS in GRAMS for 2019 (As of 10 January 2019 )
ESTIMATED WORLD REQUIREMENTS OF NARCOTIC DRUGS IN GRAMS FOR 2019 (as of 10 January 2019 ) Afghanistan Cannabis 50 Codeine 50 000 Cannabis resin 1 Dextropropoxyphene 10 000 Coca leaf 1 Diphenoxylate 5 000 Cocaine 15 Fentanyl 1 Codeine 650 000 Methadone 20 000 Codeine -N-oxide 1 Morphine 8 000 Dextromoramide 1 Pethidine 90 000 Dextropropoxyphene 200 000 Pholcodine 40 000 Difenoxin 1 Albania Dihydrocodeine 1 Cocaine 1 Diphenoxylate 1 Codeine 1 189 000 Dipipanone 1 Fentanyl 300 Ecgonine 2 Heroin 1 Ethylmorphine 1 Methadone 7 000 Etorphine 1 Morphine 7 800 Fentanyl 17 000 Oxycodone 2 000 Heroin 1 Pethidine 2 700 Hydrocodone 10 000 Pholcodine 1 500 Hydromorphone 4 000 Remifentanil 9 Ketobemidone 1 Sufentanil 2 Levorphanol 1 Algeria Methadone 100 000 Alfentanil 350 Morphine 1 550 000 Codeine 2 500 000 Morphine -N-oxide 1 Etorphine 1 Nicomorphine 1 Fentanyl 500 Norcodeine 1 Methadone 4 000 Normethadone 1 Morphine 9 000 Normorphine 1 Oxycodone 4 000 Opium 10 Pethidine 3 000 Oripavine 1 Pholcodine 1 500 000 Oxycodone 60 000 Remifentanil 1 Oxymorphone 1 Sufentanil 30 Pethidine 50 000 Andorra Phenoperidine 1 Cannabis 2 000 Pholcodine 1 Fentanyl 100 Piritramide 1 Methadone 1 000 Remifentanil 20 000 Morphine 500 Sufentanil 10 Oxycodone 2 000 Thebacon 1 Pethidine 500 Thebaine 70 000 Remifentanil 4 Tilidine 1 Angola Armenia Alfentanil 20 Codeine 3 000 Codeine 21 600 Fentanyl 40 Dextromoramide 188 Methadone 13 500 Dextropropoxyphene 200 Morphine 7 500 Dihydrocodeine 500 Thebaine 15 Diphenoxylate 300 Trimeperidine 1 500 Fentanyl 63 Aruba* Methadone 2 000 -
A Review of Unique Opioids and Their Conversions
A Review of Unique Opioids and Their Conversions Jacqueline Cleary, PharmD, BCACP Assistant Professor Albany College of Pharmacy and Health Sciences Adjunct Professor SAGE College of Nursing DISCLOSURES • Kaleo • Remitigate, LLC OBJECTIVES • Compare and contrast unique pharmacotherapy options for the treatment of chronic pain including: methadone, buprenoprhine, tapentadol, and tramadol • Select methadone, buprenorphine, tapentadol, or tramadol based on patient specific factors • Apply appropriate opioid conversion strategies to unique opioids • Understand opioid overdose risk surrounding opioid conversions and the use of unique opioids UNIQUE OPIOIDS METHADONE, BUPRENORPHINE, TRAMADOL, TAPENTADOL METHADONE My favorite drug because….? METHADONE- INDICATIONS • FDA labeled indications – (1) chronic pain (2) detoxification Oral soluble tablets for suspension NOT indicated for chronic pain treatment • Initial inpatient detoxification of opioids by a licensed trained provider with methadone and supportive care is appropriate • Methadone maintenance provider must have special credentialing and training as required by state Outpatient prescription must be for pain ONLY and say “for pain” on RX • Continuation of methadone maintenance from outside provider while patient is inpatient for another condition is appropriate http://cdn.atforum.com/wp-content/uploads/SAMHSA-2015-Guidelines-for-OTPs.pdf MECHANISM OF ACTION • Potent µ-opioid agonist • NMDA receptor antagonist • Norepinephrine reuptake inhibitor • Serotonin reuptake inhibitor ADVERSE EVENTS -
Antimicrobial Stewardship Guidance
Antimicrobial Stewardship Guidance Federal Bureau of Prisons Clinical Practice Guidelines March 2013 Clinical guidelines are made available to the public for informational purposes only. The Federal Bureau of Prisons (BOP) does not warrant these guidelines for any other purpose, and assumes no responsibility for any injury or damage resulting from the reliance thereof. Proper medical practice necessitates that all cases are evaluated on an individual basis and that treatment decisions are patient-specific. Consult the BOP Clinical Practice Guidelines Web page to determine the date of the most recent update to this document: http://www.bop.gov/news/medresources.jsp Federal Bureau of Prisons Antimicrobial Stewardship Guidance Clinical Practice Guidelines March 2013 Table of Contents 1. Purpose ............................................................................................................................................. 3 2. Introduction ...................................................................................................................................... 3 3. Antimicrobial Stewardship in the BOP............................................................................................ 4 4. General Guidance for Diagnosis and Identifying Infection ............................................................. 5 Diagnosis of Specific Infections ........................................................................................................ 6 Upper Respiratory Infections (not otherwise specified) .............................................................................. -
Recommended Methods for the Identification and Analysis of Fentanyl and Its Analogues in Biological Specimens
Recommended methods for the Identification and Analysis of Fentanyl and its Analogues in Biological Specimens MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES Laboratory and Scientific Section UNITED NATIONS OFFICE ON DRUGS AND CRIME Vienna Recommended Methods for the Identification and Analysis of Fentanyl and its Analogues in Biological Specimens MANUAL FOR USE BY NATIONAL DRUG ANALYSIS LABORATORIES UNITED NATIONS Vienna, 2017 Note Operating and experimental conditions are reproduced from the original reference materials, including unpublished methods, validated and used in selected national laboratories as per the list of references. A number of alternative conditions and substitution of named commercial products may provide comparable results in many cases. However, any modification has to be validated before it is integrated into laboratory routines. ST/NAR/53 Original language: English © United Nations, November 2017. All rights reserved. The designations employed and the presentation of material in this publication do not imply the expression of any opinion whatsoever on the part of the Secretariat of the United Nations concerning the legal status of any country, territory, city or area, or of its authorities, or concerning the delimitation of its frontiers or boundaries. Mention of names of firms and commercial products does not imply the endorse- ment of the United Nations. This publication has not been formally edited. Publishing production: English, Publishing and Library Section, United Nations Office at Vienna. Acknowledgements The Laboratory and Scientific Section of the UNODC (LSS, headed by Dr. Justice Tettey) wishes to express its appreciation and thanks to Dr. Barry Logan, Center for Forensic Science Research and Education, at the Fredric Rieders Family Founda- tion and NMS Labs, United States; Amanda L.A. -
Comparison of Three Intraoperative Analgesic Strategies in Laparoscopic Bariatric Surgery – a Retrospective Study of Immediate Postoperative Outcomes
Journal Pre-proof Comparison of three intraoperative analgesic strategies in laparoscopic bariatric surgery – a retrospective study of immediate postoperative outcomes Leopoldo Muniz da Silva, Anthony M.H. Ho, Daniel Rodrigues de Oliveira, Arthur de Campos Vieira Abib, Saullo Queiroz Silveira, Anna Beatriz Aranha, Vitor Oliveira Andre,´ Patr´ıcia Renno´ Pinto, Rafael Souza Fava Nersessian, Glenio B. Mizubuti PII: S0104-0014(21)00254-2 DOI: https://doi.org/10.1016/j.bjane.2021.06.006 Reference: BJANE 744200 To appear in: Brazilian Journal of Anesthesiology (English edition) Received Date: 7 October 2020 Accepted Date: 12 June 2021 Please cite this article as: { doi: https://doi.org/ This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. © 2020 Published by Elsevier. BJAN-D-20-00282_Clinical Research Comparison of three intraoperative analgesic strategies in laparoscopic bariatric surgery – a retrospective study of immediate postoperative outcomes Leopoldo Muniz da Silvaa,*, Anthony M.H. Hob, Daniel Rodrigues de Oliveiraa, Arthur de Campos Vieira Abiba, Saullo Queiroz Silveiraa, Anna Beatriz Aranhaa, Vitor Oliveira Andréa, Patrícia Rennó Pintoa, Rafael Souza Fava Nersessiana, Glenio B. -
General a Number of Factors Could Reduce the Efficacy of This
AUSTRALIAN PRODUCT INFORMATION Administration It is strongly recommended that every time that GAMUNEX® is administered to a patient, the name Use in the elderly GAMUNEX® If dilution is required, GAMUNEX® may be diluted with 5% dextrose in water (D5/W). Do not and batch number of the product are recorded using the supplied tear off labels in order to maintain See Section 4.4 Special warnings and precautions for use: Use in renal impairment. a link between the patient and the batch of the product. (NORMAL IMMUNOGLOBULIN (HUMAN), 10%, INTRAVENOUS SOLUTION VIAL) dilute with saline. Paediatric use Anaphylaxis GAMUNEX® should be inspected visually for particulate matter and discoloration prior to adminis - No data available. GAMUNEX® should be administered only intravenously or subcutaneously. On rare occasions, tration, whenever solution and container permit. Do not use if turbid and/or if discoloration is Effects on laboratory tests 1 NAME OF THE MEDICINE observed. treatment with an immune globulin preparation may cause a precipitous fall in blood pressure and a Interference with serological testing Normal immunoglobulin (Human), 10%, for Intravenous or Subcutaneous Administration For intravenous or subcutaneous administration, GAMUNEX® should be at room temperature during clinical picture of anaphylaxis, even when the patient is not known to be sensitive to immune globulin administration. preparations. Adrenalin and other appropriate supportive care should be available for the treatment After injection of immunoglobulin the transitory rise of the various passively transferred antibodies of an acute anaphylactic reaction. in the patient’s blood may result in misleading positive results in serological testing. Passive Intravenous (IV) True anaphylactic reactions to GAMUNEX® may occur in recipients with documented prior histories transmission of antibodies to erythrocyte antigens e.g. -
The Use of Remifentanil As the Primary Agent for Analgesia in Parturients
The Use Of Remifentanil As The Primary Agent For Analgesia In Parturients Author: Bryan Clifford Anderson, DNAP, CRNA Learning Objectives for this Self Study: The Importance of Exploring Remifentanil as an Upon completion of this study, the CRNA will be able to: Option for Treating Labor Pain The use of remifentanil in the parturient as the primary analgesic is 1. Discuss the significance of remifentanil use as a primary analgesic significant for several reasons; the most salient of which is the basic human agent in parturients for whom neuraxial anesthesia is not an option. right to the management of pain. Pain, as defined by the International Association for the Study of Pain (IASP), is “an unpleasant sensory and 2. Identify clients in which neuraxial anesthesia might be contraindicated. emotional experience associated with actual or potential tissue damage.” 2 Labor is a cause of severe pain for many women and is a problem that should 3. Compare the efficacy of select medications in the control of pain be addressed and managed in accordance with the needs and wishes of the in paturients. individual patient. Interventions that alleviate or eliminate pain are not merely a matter of beneficence, but also form part of the duty to prevent harm.3 4. Appraise findings in current evidence to determine to what extent The variations in pain perception among women in labor creates an essential remifentamil is a viable option for pain management in parturient patients. component in the administration of anesthesia in the provision of patient- centered anesthesia care. One recent study identifies that the perception of 5. -
Polymyxin B Use Associated with Severe Hypotensive Episodes
ntimicrob Mehta et al., J Antimicro 2015, 1:1 A ia f l o A l g DOI: 10.4172/2472-1212.1000102 a e n n r Journal of t u s o J ISSN: 2472-1212 Antimicrobial Agents Case Report Open Access Polymyxin B use Associated with Severe Hypotensive Episodes Mehta M1*, Baron JM1, Nelson BC1, Muir J1 and Pereira MR2 1NewYork-Presbyterian Hospital, USA 2Columbia University Medical Center, USA Abstract Polymyxin B was developed in the 1940s but was infrequently used because of renal toxicity. Since the rise of infections due to multidrug resistant gram-negative organisms, polymyxin B has re-emerged as an important agent. However, its toxicity is still not fully elucidated. In this report, we describe two cases of multiple hypotensive events occurring after polymyxin B administration. Management strategies, such as slowing the infusion rate and administering diphenhydramine, did not mitigate the hypotension. We also describe relatively high polymyxin levels correlated with this effect in one of these cases. Keywords: Polymyxin; Toxicity; Hypotension While hypotension is usually a complication of sepsis, details in this case suggest that the episodes of hypotension are more related Case 1 to polymyxin B administration than an uncontrolled infection. The A 35-year-old-woman was admitted to our hospital for management episodes of hypotension started to occur only after polymyxin B and of newly diagnosed acute promyelocytic leukemia. Twelve days after other antibiotics were initiated. There is good evidence, with negative initiation of chemotherapy, she developed a fever to 38.0°C. Cultures follow-up cultures, resolution of fever, and improving imaging, that of her urine and blood grew a carbapenem-resistant Escherichia coli the infection was controlled by the time that the hypotensive episodes susceptible to polymyxin B (minimum inhibitory concentration started. -
Package Insert
response and target IgG at 15 mL/hr/site 20 mL/hr/site HIGHLIGHTS OF PRESCRIBING trough level (2.2). INFORMATION . Ensure that patients with pre-existing renal insufficiency are not volume depleted; discontinue GAMMAGARD LIQUID if renal function These highlights do not include all the information needed to use deteriorates. (2.3, 5.2) GAMMAGARD LIQUID safely and effectively. See full prescribing . For patients at risk of renal dysfunction or thrombotic events, administer information for GAMMAGARD LIQUID. GAMMAGARD LIQUID at the minimum infusion rate practicable. (2.3, 5.2, 5.4) GAMMAGARD LIQUID, Immune Globulin Infusion (Human), 10% --------------DOSAGE FORMS AND STRENGTHS--------- Solution, for intravenous and subcutaneous administration . Aqueous solution containing 10% IgG (100 milligram/mL) (3) ---------------------CONTRAINDICATIONS ------------------- Initial U.S. Approval: 2005 . Anaphylactic or severe systemic hypersensitivity reactions to Immune Warning: RENAL DYSFUNCTION & ACUTE RENAL FAILURE Globulin (Human) (4) See full prescribing information for complete boxed warning . IgA deficient patients with antibodies against IgA and a history of . Renal dysfunction, acute renal failure, osmotic nephropathy, and hypersensitivity (4) death may occur with immune globulin intravenous (IGIV) -----------------WARNINGS AND PRECAUTIONS---------- products in predisposed patients. Renal dysfunction and acute . IgA deficient patients with antibodies to IgA are at greater risk of developing failure occur more commonly in patients receiving IGIV severe hypersensitivity and anaphylactic reaction. (5.1) products containing sucrose. GAMMAGARD LIQUID does not . Monitor renal function, including blood urea nitrogen, serum creatinine, and contain sucrose. urine output in patients at risk of acute renal failure. (5.2) . For patients at risk of renal dysfunction or failure, administer . Hyperproteinemia, increased serum viscosity and hyponatremia may occur.