MICHAL SHARON CURRICULUM VITAE June 20 20 A

MICHAL SHARON CURRICULUM VITAE June 20 20 A . PERS ONA L DETAILS Date of Birth: March 25th 1972 Country of Birth: Israel Citizenship: Israeli, German Marital Status: Married, +3 (Ori 1998, Naama 2001, Ronni 2007) Phone: +972-8-9343947 Fax: +972-8-9346010 E-mail: [email protected] Webpage: http://www.weizmann.ac.il/Biomolecular_Sciences/MichalSharon/home ORCID ID: 0000-0003-3933-0595

B. EDUCATION 2003-2006 Post-doctoral research under Prof. Carol V. Robinson, Department of Chemistry, University of Cambridge, Cambridge, UK. Field of study: Mass spectrometry of large non-covalent complexes. 1996-2003 M.Sc./Ph.D. combined program (direct PhD) under Prof. Jacob Anglister, Department of Structural Biology, Weizmann Institute of Science, Rehovot, Israel. Field of study: Three-dimensional structure determination of protein complexes using multidimensional NMR 1993-1996 B.Sc. Chemistry, The Hebrew University, Jerusalem, Israel, Cum laude.

C. EMPLOYMENT 2015-present Associate Professor, Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel. 2007-2015 Senior Scientist (equivalent to Assistant Professor), Department of Biological Chemistry, Weizmann Institute of Science, Rehovot, Israel. 2006-2007 Royal Society Research Fellow, Department of Chemistry, University of Cambridge, Cambridge, UK.

D. ACADEMIC ADMINISTRAT ION 2020 WIS Representative, Steering Committee of Israeli Universities for COVID-19 Policy 2020 Members of the COVID-19 Mass Spectrometry Coalition 2020 Head of Committee, Journal of Mass Spectrometry Award 2019-present Elected to the National Forum of Promoting Women Scientists 2019 Member of Review Committee, Israel Science Foundation (ISF) 2019 Member of the Committee, Young Weizmann Scholars Program for the Arab Sector 2018 Member of Judgment Committee, Falling Walls Conference 2017-2020 Vice President of ILANIT, federation of 32 Israeli Societies of Experimental Biology 2017-2020 Head of Division of Research Services, Weizmann Institute 2017 Member of the Committee, Appointment of Senior Scientists, Life Sciences Faculties 2016-2017 Board Member, Schwartz/Reisman Science Education Center, Rishon LeZion

1 2016-present Head of the Proteomics Unit Advisory Committee, Israel National Center for Personalized Medicine (INCPM) 2016-present Member of the Davidson Institute Steering Committee, Northern Israel Educational Activities 2015-present Education Officer, International Mass Spectrometry Foundation (IMSF) 2014-2018 Management Board, COST (European Cooperation in Science and Technology)-Action BM1403 “Native Mass Spectrometry and Related Methods for Structural Biology” 2014-2018 Vice-President, Israeli Biochemistry Society 2013-2016 President, Israeli Mass Spectrometry Society 2013-2017 Board Member, Hemda Center for Science Education, Rehovot 2013-2014 Member, Katzir Travel Fellowship Committee 2013-2014 Board Member, Israeli Biochemistry Society 2013-2016 Member, Proteomics Unit Advisory Committee, Israel National Center for Personalized Medicine (INCPM) 2013 Organizer, Biological Chemistry Departmental Retreat 2012-2013 Vice-President, Israeli Mass Spectrometry Society 2011‐2013 Organizer, Biological Chemistry Departmental Seminars 2011-2012 Senior Scientists Representative, Scientific Council of the Weizmann Institute 2009 Member, Steering Committee on the Involvement in Instruct: EU Hub for Structural Biology 2009 Member, Kadima Mada - Weizmann Institute Excellence Award Committee

E. OTHER APPOINTEMEN TS TEACHING ACTIVITIES 2020 Structural Mass Spectrometry Workshop, Bordeaux, France 2020 Quantitative Proteomics: Strategies and Tools to Probe Biology, Heidelberg, Germany 2019 International Mass Spectrometry School, Barcelona, Spain 2019 Advancing Mass Spectrometry Workshop, Amherst, USA 2019 ASMS Tutorial Lecture on “Native Mass Spectrometry”, Atlanta, USA 2019 Native MS Guided Structural Biology Workshop, MA, USA 2017 Lecturer and Organizer, International Structural Mass Spectrometry Workshop, Rehovot, Israel 2016 Lecturer, Practical Course on “Top Down and Structural Mass Spectrometry”, Lisbon, Portugal 2015 Lecturer, 9th European Summer School of "Advanced Proteomics", Brixen, Italy 2014-present Lecturer, Course on “Chromatography and Mass Spectrometry for Analysis of Biomolecules”, Feinberg Graduate School, Weizmann Institute of Science (taught together with other teachers) 2013 7th European Summer School of "Advanced Proteomics", Brixen, Italy 2012 Graduate School Spring Meeting, Martin-Luther-Universität Halle-Wittenberg, Germany 2011 EMBO Practical Course on “Protein-Protein and Protein-Nucleic Acid Cross-Linking and Mass Spectrometry”, Göttingen, Germany 2011 Lecturer, Course on “Biochemistry of Enzymes and Proteins”, The Hebrew University of Jerusalem (taught together with other teachers) 2010 Lecturer and Coordinator Course on “Advanced Protein Science”, Feinberg Graduate School, Weizmann Institute of Science (alongside Profs. Dan Tawfik and Gideon Schreiber) 2009, 2010 Lecturer, Course on “Theoretical Basis of Common Lab Techniques Course”, Weizmann Institute of Science (taught together with other teachers)

2 EDUCATIONAL OUTREACH ACTIVITIES 2017-present Initiator and organizer of the “Private Investigator” column in YNET (Israeli news website) 2016 EuroScience Open Forum, “Mass Spectrometry for the Masses”, Manchester, UK 2015-present Initiator and Lecturer of a Workshop Focusing on “Combining Motherhood and a Scientific Career”, Weizmann Institute, (alongside Profs. Nirit Dudovich and Maya Schuldiner) 2014 Lecturing for PhD Students on “How to Write a Good CV” 2009 Lecturing at the Taasiya Avirit Evening Program Organized by the Davidson Institute for Science Education, Rehovot, Israel 2009 Giving the “Amos de-Shalit Lecture”, Weizmann, Institute, Rehovot, Israel 2009 Lecturing at ‘The Raya Cowan International Summer School’ program of the Feinberg Graduate School 2008, 2009 Lecturing at various evening programs organized by the Davidson Institute for Science Education, Rehovot, Israel 2008, 2009 Lecturing at the “Amos de-Shalit Ulpana” for both Chemistry and Biology, Weizmann, Institute, Rehovot, Israel

F. INTERNATIONAL REC OGNITION

PRIZES AND AWARDS

2019 Elected to the “Leading in Academia” program for outstanding scientists 2018 Mass Spectrometry in the Life Sciences Award, European Mass Spectrometry Conference 2017 Elected to the Young Israeli National Academy of Science 2014 ERC Starting Grant from the EU (LS1) 2009 ERC Starting Grant from the EU (PE4) 2008 Research Career Development award, ICRF 2007 Elected as Life Member Clare Hall College, University of Cambridge, UK 2006 Dorothy Hodgkin Royal Society fellowship 2006 Research fellow at Clare Hall College, University of Cambridge, UK 2004 Wingate Scholarship 2004 EMBO Postdoctoral Fellowship 2004 Israel Chemical Society Prize for Excellence in PhD Studies 2003 Bikura Post-Doctoral Fellowship Founded by the Israeli Academy of Science and Humanities. 2001 Salim and Rachel’s Fund of Excellence Education 1996 Magna cum laude in Chemistry, the Hebrew University, Jerusalem 1995 Dean Prize, the Hebrew University, Jerusalem 1995 Elving Prize for High Achievements in Analytical Chemistry, the Hebrew University, Jerusalem

INTERNATIONAL ORGANIZING COMMITTEES 2021 Initiator and Organizer, 1st Meeting on 20S Proteasome Degradation, Rehovot, Israel 2020 Session Organizer, 9th ILANIT Meeting, Eilat, Israel 2018 Initiator and Organizer, Proteasome Hub: Fine-Tuning of Proteolytic Machines, Munich, Germany 2017 Initiator and Organizer, International Structural Mass Spectrometry Workshop, Rehovot, Israel 2017 Organizer, FEBS Meeting, Jerusalem, Israel

3 2017 Session Organizer, 8th ILANIT meeting, Eilat, Israel 2017 Organizer, 29th Meeting of the Israel Society for Mass Spectrometry Joint with the American Mass Spectrometry Society, Rehovot, Israel 2017 Co-Initiator and Organizer, Ubiquitin-Proteasome System Israeli Club 2016 Organizer, 10th Parnas Conference, Wrocław, Poland 2016 Organizer, 28th Meeting of the Israel Society for Mass Spectrometry Joint with the British Mass Spectrometry Society, Rehovot, Israel 2015 Session Organizer, 63rd ASMS Conference on Mass Spectrometry & Allied Topics, St. Louis, USA 2014 Chair of the Organizing Committee, Israel Biochemistry Society Annual Meeting, Rehovot, Israel 2014 Organizer, 27th Meeting of the Israel Society for Mass Spectrometry Joint with the Swiss Mass Spectrometry Society, Rehovot, Israel 2014 Session Organizer, 20th International Mass Spectrometry Society Conference, Geneva, Switzerland 2014 Session Organizer, 7th ILANIT meeting, Eilat, Israel 2013 Organizer, 26th Meeting of the Israel Society for Mass Spectrometry Joint with the German Mass Spectrometry Society, Israel 2010 Organizer, 1st Middle Eastern and Mediterranean Sea Region Countries Mass Spectrometry, Rehovot, Israel 2010 Organizer, Zomes 6, Expanding the PCI Family Beyond Proteasome, CSN and eiF3, Safed, Israel 2008 Organizer, 7th Congress of the Israel Association for Medicinal Chemistry, Rehovot, Israel

REVIEW AND EDITORIAL APPOINTMENTS 2019-2021 Features Panel Advisory Board, Journal of Analytical Chemistry 2012-2016 Member of the Editorial Board of Current Opinion in Structural Biology 2011 Editor, alongside Prof. Carol V. Robinson, "Biophysical Methods” Issue of Current Opinion in Structural Biology

TALKS AT INTERNATIONAL MEETINGS 2021 EMBO Workshop on Protein Quality Control, Dubrovnik, Croatia 2021 GRC on Intrinsically Disordered Proteins, Les Diablerets, Switzerland (postponed) 2021 2nd Fusion Conference on Ubiquitin Function in Health and Disease, Lisbon, Portugal 2021 Biocenter PhD Symposium - 20/20 The Vision is Clear, Vienna, Austria 2021 Quantitative Proteomics: Strategies and Tools to Probe Biology, Heidelberg, Germany 2020 Ultrahigh Molecular Weight Mass Spectrometry Workshop, Lake Louise, Canada 2020 Ubiquitin and Friends Symposium, Vienna BioCenter Webinar 2020 MOMbrane Workshop – Weizmann-Tübingen, Tubingen, Germany (postponed) 2020 The Molecular Fabric of Life, Jerusalem, Israel 2020 Production and Function of EVs in Infectious Disease, Rehovot, Israel 2020 The 4th Zavalkoff Symposium, Rehovot, Israel 2020 Protein Degradation Congress, San Diego, USA 2019 EMBO Workshop on the Ubiquitin System, Cavtat, Croatia 2019 EMBL Conference Proteomics in Cell Biology and Disease Mechanisms, Heidelberg, Germany

4 2019 Advancing Mass Spectrometry for Biophysics and Structural Biology, Amherst, USA 2019 Celebration of Native Mass Spectrometry, Oxford, UK 2019 X-ZOMES on the Broader Cellular Impact of PCI Complexes, Akko, Israel 2019 European Top-Down Proteomics Workshop, Paris, France 2018 8th Symposium on Structural Proteomics, Berlin, Germany 2018 Opening Symposium Charles Tanford Protein Center, Halle, Germany 2018 22nd International Mass Spectrometry Society Conference, Florence, Italy 2018 GRC on Intrinsically Disordered Proteins, Les Diablerets, Switzerland 2018 EMBO Workshop on In Situ Methods in Cell Biology & Cellular Biophysics, Berlin, Germany 2018 Keynote Speaker, 22nd International Mass Spectrometry Society Conference, Florence, Italy 2018 European Mass Spectrometry Conference, Saarbrücken, Germany 2018 Proteasome Hub: Fine‐Tuning of Proteolysis According to Cellular Needs, Munich, Germany 2018 Isolated Biomolecules Biomolecular Interactions, Texel, Netherlands 2018 IISER-WIS Conference on Chemical Biology, Pune, India 2017 Molecular Perspectives on Protein-Protein Interactions, Eilat, Israel 2017 31st Annual Symposium of the Protein Society, Montreal, Canada 2017 Native Mass Spectrometry – Instrumentation and Applications. Crete, Greece 2017 3rd International p53 Isoform Workshop, Bergen, Norway 2017 Zomes IX, Zome Complexes and the Ubiquitin-Proteasome System, Rome, Italy 2017 8th ILANIT Meeting, Eilat, Israel 2017 Israel Society for Mass Spectrometry Joint with USA Society, Rehovot, Israel 2016 21st International Mass Spectrometry Society Conference, Toronto, Canada 2016 7th Proteasomes & Autophagy Workshop, Clermont-Ferrand, France 2016 MPI-MoIPhy Mini-Symposium on Chemical and Molecular Biology, Rehovot, Israel 2016 Women in Structural Biology, Grenoble, France 2015 Receptor Dynamics - Winter School International Doctoral Program, Rehovot, Israel 2015 5th Symposium on Structural Proteomics, Halle, Germany 2015 Swedish Mass Spectrometry Society Annual Meeting, Johannesbergs Castle, Sweden 2015 Native Mass Spectrometry Minisymposium, Hamburg, Germany 2015 International Symposium on Ubiquitin and Diseases, Zhangjiajie, China 2015 3rd Mass Spectrometry Workshop, Gdańsk, Poland 2015 Winter School on Receptor Dynamics & Paradigms for Novel Drugs, Rehovot, Israel 2015 5th Symposium on Structural Proteomics, Halle, Germany 2015 Posttranslational Modifications of Proteins Analysis and Functions, Haifa, Israel 2015 Keystone Symposium on The Human Proteome, Stockholm, Sweden 2015 Isranalytica, 18th Annual Meeting of the Israel Analytical Chemistry Society, Tel-Aviv, Israel 2014 4th Symposium on Structural Proteomics, Antwerp, Belgium 2014 Zomes VIII, Biology of the Zomes, Xiamen, China 2014 GRC on Intrinsically Disordered Proteins, MA, USA 2014 ASMS meeting on Ion Activation, FL, USA 2014 The 79th Annual meeting of the Israel Chemical Society, Tel-Aviv, Israel 2014 7th ILANIT meeting, Eilat, Israel 2013 GRC on Biological Molecules in the Gas Phase and in Solution, NH, USA 2013 The Ubiquitin Family, Cold Spring Harbour Laboratory, NY, USA

5 2013 DGMS Deutschen Gesellschaft für Massenspektrometrie, Berlin, Germany 2013 Israeli Biophysical Society meeting, Jerusalem, Israel 2013 Proteins from Birth to Death conference, Jerusalem, Israel 2013 WIS-MBI Mechanobiology Conference, Dynamic Architecture of Cells & Tissues, Singapore 2012 Zomes VI, Ubiquitin Family Proteins and Their Cognate PCI Complexes, Munich, Germany 2012 Keystone Symposia on Proteomics, Interactomes, Stockholm, Sweden 2012 MASSA 2012, the National Symposium on Mass Spectrometry, Palermo, Italy 2012 2nd Greek Orbitrap Users Meeting, Irakilo, Crete 2012 Protein Degradation Pathways in Health and Diseases, San-Diego, USA 2011 Proteomics Symposia at Children's Hospital Boston, Boston, USA 2011 International Proteomics Meeting, Athens, Greece 2011 Keystone Symposia, AAA+ and Related ATP-Driven Protein Machines, Tahoe City, USA 2011 6th ILANIT Meeting, Eilat, Israel 2010 ESF meeting, Molecular Perspectives on Protein-Protein Interactions, Sant Feliu, Spain 2010 1st Middle Eastern and Mediterranean Sea Region Countries MS Workshop, Rehovot, Israel 2010 Zomes VI, Expanding the PCI Family Beyond Proteasome, CSN and eiF3, Safed, Israel 2010 French-Israeli ERC Recipients Interdisciplinary Symposium, Jerusalem, Israel 2010 58th ASMS Conference on Mass Spectrometry, Salt Lake City, USA 2009 18th International Mass Spectrometry Conference, Bremen, Germany 2009 The 74th Israel Chemistry Society Annual Meeting, Tel-Aviv, Israel 2009 Biological Chemistry Symposium, Beer-Sheva, Israel 2009 The 22nd Meeting of the Israeli Society for Mass Spectrometry, Technion, Haifa, Israel 2008 Zomes V, The COP9 Signalosome, Proteasome and eiF3, Yokohama, Japan 2008 56th ASMS Conference on Mass Spectrometry, Colorado, USA 2008 CFN-RBNI-WIS Symposium on Nanotechnology, Karlsruhe, Germany 2008 4th Structural Analysis of Supramolecular Assemblies by Hybrid Methods, Lake Tahoe, USA 2008 5th ILANIT Meeting, Eilat, Israel 2007 The 21st Meeting of the Israeli Society for Mass Spectrometry, Rehovot, Israel 2005 Katzir Conference, Molecular Perspectives on Protein-Protein Interactions, Eilat, Israel 2006 54th ASMS Conference on Mass Spectrometry, Seattle, USA.

INVITED SEMINARS 2020 Molecular Systems Biology Seminar, ETH Zurich, Switzerland 2019 Interfaculty Institute of Biochemistry University of Tuebingen Seminar, Tuebingen, Germany 2019 Thermo Fisher Scientific Seminar, San Jose, USA 2019 Department of Biological Chemistry, Hebrew University of Jerusalem, Israel 2018 WhatsUp Seminar Series, Waters Corporation, Wilmslow, UK 2018 Barcelona Biomed Plenary Seminars, IRB Barcelona, Spain 2017 School of Chemistry Seminar, University of Manchester, UK 2016 Department of Medical Sciences, University of Toronto, Canada 2016 Department of Biotechnology Engineering, Beer-Sheva, Israel 2016 Waters Corporation Seminar, Wilmslow, UK 2015 German Institute of Human Nutrition, Potsdam, Germany

6 2015 Molecular Biology & Genetics, Johns Hopkins University School of Medicine, USA 2014 Chemical and Molecular Biology and Structural Biology Seminar, Ohio State University, USA 2014 Department of Pharmacy, Università di Salerno, Italy 2014 Department of Structural Biology, Weizmann Institute, Rehovot, Israel 2013 Physical and Theoretical Chemistry Laboratory, University of Oxford, UK 2013 MRC Laboratory of Molecular Biology, Cambridge, UK 2013 Division of Structural Biology, The Institute of Cancer Research, London, UK 2013 Department of Biological Chemistry, Hebrew University of Jerusalem, Israel 2013 Department of Biochemistry & Molecular Biology, Hebrew University of Jerusalem, Israel 2012 Department of Molecular Biology, The Scripps Research Institute, La Jolla, CA, USA 2012 Signal Transduction Program, Sanford-Burnham Medical Research Institute, La Jolla, USA 2012 Beckman Institute, California Institute of Technology, Pasadena, CA, USA 2011 Colloquium of Microbiology and Structure-Biology, University of Göttingen, Germany 2011 The Israel Institute for Biological Research, Ness-Ziona, Israel 2011 Department of Biology, MIT, Boston, USA 2011 Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, USA 2011 Department of Cell Biology, Harvard Medical School, Boston, USA 2011 Life Sciences Faculty & Nano-Medicine Research Center, Bar-Ilan University, Israel 2011 Department of Molecular Microbiology and Biotechnology, Tel-Aviv University, Israel 2009 Structural Bioinformatics Group, Tel-Aviv University, Tel-Aviv, Israel 2009 Institute Jacques Monod, Université Paris Diderot-Paris 7, Paris, France 2009 Biologie Cellulaire et Infection, Institute Pasteur, Paris, France 2009 Department of Life Sciences and the NIBN, University of Ben-Gurion in the Negev, Israel 2009 Department of Biological Chemistry, Hebrew University of Jerusalem, Israel 2008 Institute of Chemistry, Hebrew University of Jerusalem, Israel 2008 Department of Plant Sciences, Weizmann Institute, Rehovot, Israel 2006 NIH Proteomics Interest Group