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Nouvelles Approches En Neurosciences Et Maladies Du Systeme Nerveux Central

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Nouvelles Approches En Neurosciences Et Maladies Du Systeme Nerveux Central NOUVELLES APPROCHES EN NEUROSCIENCES ET MALADIES DU SYSTEME NERVEUX CENTRAL THE FUTURE OF NEUROSCIENCES : FUNDAMENTAL RESEARCH AND DISEASES OF THE BRAIN Programme et résumés Paris, 10-11 mai 2004 Académie des sciences de l’Institut de France 23 Quai de Conti - 75006 Paris Salle Hugot copyright Institut de France - Paris, 12 mai 2004 nations cl. G. Fessy - Académie nationale de médecine 16 rue Bonaparte - 75006 Paris Amphithéâtre Ancien Collège des Quatre – e l’Institut de France Palais d NOUVELLES APPROCHES EN NEUROSCIENCES ET MALADIES DU SYSTEME NERVEUX CENTRAL THE FUTURE OF NEUROSCIENCES : FUNDAMENTAL RESEARCH AND DISEASES OF THE BRAIN Présidents Nicole Le Douarin, Secrétaire perpétuelle de l’Académie des sciences Henri Korn, de l’Académie des sciences Comité scientifique Étienne-Émile Baulieu, Président de l’Académie des sciences, Jacques-Louis Binet, Secrétaire perpétuel de l’Académie nationale de médecine, Bertrand Fontaine, professeur CHU Pitié-Salpêtrière, Chris Frith, Academy of Medical Sciences of the United Kingdom, Marc Jeannerod, de l’Académie des sciences, Henri Korn, de l’Académie des sciences, Jean-Yves Lallemand, de l’Académie des sciences, Nicole Le Douarin, Secrétaire perpétuelle de l’Académie des sciences, Robert Naquet, de l’Académie des sciences, Jean Rosa, de l’Académie des sciences, André Syrota, directeur des sciences du vivant CEA, Antoine Triller, directeur de l’Unité Inserm U497, Jean-Didier Vincent, de l’Académie des sciences, de l’Académie nationale de médecine Colloque organisé en collaboration avec l’Académie nationale de médecine et l’Academy of Medical Sciences of the United Kingdom Avec le soutien de FIRAS Fondation internationale pour le rayonnement de l’Académie des sciences Organisation Fabienne Bonfils, assistée de Christine Martin et Noëlla Morand Service des colloques - Académie des sciences - Institut de France Lundi 10 mai 2004 - Académie des sciences 9h00 Ouverture / Welcome address Étienne-Émile Baulieu, Nicole Le Douarin, Jacques-Louis Binet, Henri Korn 9h10 Conférence plénière / Plenary Lecture Intégration entre différentes échelles spatio-temporelles des signaux neuronaux Integrating Neuroscientific Data Across Spatiotemporal Scales Barry Horwitz, National Institutes of Health, Bethesda Session 1 Moyens d'investigation des fonctions intégrées Investigation of Higher Functions Président / Chairman : André Syrota 10h00 Conférence introductive / Keynote Lecture Imagerie fonctionnelle : études de connectivité et d'électrophysiologie dans les actions neuronales de masse / Functional Imaging, Connectivity and Electrophysiology Investigations of Mass Neural Action Nikos K. Logothetis, Max Planck Institute for Biological Cybernetics, Tübingen 10h25 Activations et déactivations en imagerie fonctionnelle et leurs relations avec l'activité fonctionnelle de base / Activations and Deactivations in Functional Imaging and their Relationship to Baseline Functional Activity Marcus E. Raichle, Washington University School of Medicine, St. Louis 10h50 L'architecture fonctionnelle cérébrale révélée par l'IRM / The Functional Architecture of the Brain as Seen by MRI Denis Le Bihan, de l'Académie des sciences, Service Hospitalier F. Joliot, CEA Saclay 11h15 Discussion (15 min) + Pause Session 2 Génétique et développement des pathologies du système nerveux Genetics, Development and Brain Diseases Président / Chairman : Antoine Triller 12h00 Contrôle génétique de l'anxiété et des états proches du stress / Genetic Control of Anxiety and Stress- Like Behaviour Wolfgang Wurst, GSF National Research Center for Environment and Health, Institute of Developmental Genetics, Munich 12h25 Mécanismes pathologiques du syndrome de retard mental avec X fragile et fonction de la protéine FMRP/ The Fragile X Mental Retardation Syndrome : Pathological Mechanisms and Function of the FMRP Protein Jean-Louis Mandel, de l'Académie des sciences, Institut de génétique et de biologie moléculaire et cellulaire, Strasbourg 12h50 Discussion (10 min) Session 3 Neurosciences et maladies neurodégénératives Neuroscience and Neurodegenerative Diseases Président / Chairman : Jean-Jacques Hauw de l'Académie nationale de médecine 15h00 Conférence introductive / Keynote Lecture Maladies à prions : progrès récents et questions ouvertes / Prion Diseases : Recent Progress and Open Questions Adriano Aguzzi, Institute of Neuropathology, University Hospital of Zurich 15h40 Discussion 15h45 Biologie moléculaire et génétique de la maladie de Alzheimer / Molecular Biology and Genetics of Neurodegeneration in Alzheimer Disease Peter Saint George-Hyslop, Centre for Research in Neurodegenerative Diseases, University of Toronto 16h10 Action des neurostéroïdes au niveau des microtubules : une nouvelle approche de la neuroprotection et du traitement de la maladie de Alzheimer / Neurosteroids Acting at the Microtubule Level : Toward a Novel Approach of Neuroprotection and Treatment of Alzheimer Disease Étienne-Émile Baulieu, Président de l'Académie des sciences, membre de l'Académie nationale de médecine 16h35 Discussion (10 min) + Pause Session 3 (suite) Président / Chairman : Bertrand Fontaine 17h05 La génétique de la maladie de Parkinson / Genetics of Parkinson's Disease Alexis Brice, CHU Pitié-Salpétrière, Paris 17h30 Rôle de l'imagerie fonctionnelle pour le diagnostic et le suivi de la maladie de Parkinson / Parkinson's Disease : Functional Imaging Studies on Diagnosis and Progression David J. Brooks, Hammersmith Hospital, Imperial College of Science, London 17h55 Discussion (5 min) 18h05 Maladie de Huntington et thérapie interventionnelle / Huntington Disease and Interventional Therapy Anne-Catherine Bachoud-Levi, CHU Henri Mondor, Créteil 18h30 Discussion (5 min) Mardi 11 mai 2004 - Académie des sciences Session 4 Epilepsies, Sclérose en plaques Epilepsies, Multiple Sclerosis Président / Chairman : Robert Naquet 9h30 Neurobiologie de l'épilepsie : trop d'informations, pas asse z de certitudes / The Neurobiology of Epilepsy : too much Information, not enough Knowledge Robert Sloviter, University of Arizona, Departments of Pharmacology and Neurology, Tucson 9h55 Développement cérébral et épilepsie de l'enfant / Developmental Abnormalities in Epileptic Children Olivier Dulac, CHU Saint Vincent de Paul, Paris (Session 4 suite) 10h20 Discussion 10h30 Conséquences immunologiques et neurologiques de la sclérose en plaque / Multiple Sclerosis : Immunological Self Hatred and its Neurological Consequences Harmut Wekerle, Max Planck Institute for Neurobiology, Munich 10h55 Discussion (5 min) + Pause Session 5 Physiopathologie sensorielle Sensory Functions Président / Chairman : Marc Jeannerod 11h30 Conférence introductive / Keynote Lecture Comment l'oreille fonctionne : transduction mécano-électrique et amplification de l'information par les cellules ciliées / How the Ear's Works Work : Mechanoelectrical Transduction and Amplification by Hair Cells A. Jim Hudspeth, Rockefeller University and Howard Hughes Medical Institute, New York 11h55 Surdité héréditaire humaine : contribution à la compréhension des bases moléculaires du développement et du fonctionnement des cellules sensorielles auditives / Human Hereditary Deafness : Unravelling the Developmental and Physiological Molecular Mechanisms of the Sensory Hair Cells Christine Petit, de l'Académie des sciences, Collège de France, Institut Pasteur, Paris 12h20 Discussion (10 min) 14h30 Allocution de Monsieur François d’Aubert, Ministre délégué à la Recherche (suite de la session 5) 14h50 Rétinopathies pigmentaires : thérapeutiques potentielles au-delà des mutations Therapeutic Approaches in Retinal Dystrophies, Beyond the Discovery of Causative Genes José -Alain Sahel, CHU Saint-Antoine, Université Paris VI et Directeur de l'Unité INSERM 592 15h15 Discussion (5 min) Session 6 Troubles du comportement Behavioral Dysfunction Président / Chairman : Pierre Buser de l'Académie des sciences 15h20 Récepteurs nicotiniques et pathologies chez l'homme / Brain Nicotinic Receptors and Human Pathologies Jean-Pierre Changeux, de l'Académie des sciences, Collège de France, Institut Pasteur, Paris 15h45 Rôle de l'inhibition GABAergique dans le contrôle des fonctions cognitives et des émotions GABAergic Inhibition in the Regulation of Cognition and Emotion Hanns Möhler, Institute of Pharmacology, ETH and University of Zurich 16h10 Discussion (10 min) + Pause 16h40 Bases neurales des erreurs de perception et des hallucinations / The Neural Basis of Hallucinations and Delusions Chris Frith, Wellcome Department of Imaging Neuroscience, London 17h05 Imagerie cérébrale et autisme infantile / Brain Imaging and Childhood Autism Monica Zilbovicius, Service Hospitalier Frédéric Joliot, CEA, Orsay 17h30 Discussion (10 min) 17h40 Apport de l’imagerie dans la connaissance de l’addiction et des troubles compulsives The Addicted Brain Nora Volkow, Brookhaven National Laboratory, Upton, New York Mercredi 12 mai 2004 - Académie nationale de médecine Session 7 Nouvelles perspectives thérapeutiques Therapeutics : Future Perspectives Présidents / Chairmen : Jean-Didier Vincent et Yves Agid CHU Pitié-Salpêtrière, INSERM IFR70 9h00 Conférence introductive / Keynote Lecture Applications cliniques et biologiques des cellules souches dans le système nerveux central / Controlling Human ES Cells Ron McKay, NIH, Bethesda 9h40 Discussion 9h45 Stimulations électriques et thérapeutiques du système nerveux central / Therapeutic Electrical Stimulation of the Central Nervous System Alim Louis Benabid, de l’Académie des sciences, Inserm U318, CHU et
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