HBP FPA Amendment 1.Pdf
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Co-funded by the European Union COVER PAGE Title of Proposal: The Human Brain Project - Framework Partnership Agreement (HBP-FPA) P No. Name of Partner Organisation Short Name Country 1 École Polytechnique Fédérale de Lausanne EPFL CH 2 Aalto-korkeakoulusäätiö AALTO FI 3 Academisch Ziekenhuis Leiden - Leids Universitair Medisch Centrum LUMC NL 4 Athens University of Economics and Business AUEB GR 5 Barcelona Supercomputing Center - Centro Nacional de Supercomputacion BSC ES 6 Bauhaus University Weimar BAUW DE 7 Bergische Universität Wuppertal BUW DE 8 Bloomfield Science Museum Jerusalem BSMJ IL 9 Cardiff University CF GB 10 Centre National de la Recherche Scientifique CNRS FR 11 Commissariat a l'énergie atomique et aux énergies alternatives CEA FR 12 Consiglio Nazionale delle Ricerche CNR IT 13 Consorzio Interuniversitario Cineca CINECA IT 14 Danmarks Tekniske Universitet DTU DK 15 Debreceni Egyetem UoD HU 16 De Montfort University DMU GB 17 École Normale Supérieure ENS FR 18 Eidgenössische Technische Hochschule Zürich ETHZ CH 19 Fonden Teknologirådet FT DK 20 Forschungszentrum Jülich GmbH JUELICH DE 21 Fortiss Gmbh FORTISS DE 22 Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. FG DE 23 Fundacao D. Anna Sommer Champalimaud E Dr. Carlos Montez Champalimaud FCHAMP PT 24 Heinrich Heine Universität Düsseldorf UDUS DE 25 Helsingin yliopisto UH FI 26 HITS gGmbH HITS DE 27 Hospices Cantonaux, Centre Hospitalier Universitaire Vaudois CHUV CH 28 Imperial College of Science, Technology and Medicine ICL GB 29 Institut de Cerveau et de la Moelle Épinière ICM FR 30 Institute of Experimental Medicine, Hungarian Academy of Sciences IEM HAS HU 31 Institute of Science and Technology Austria IST AT 32 Institut Jozef Stefan JSI SI 33 Institut National de Recherche en Informatique et en Automatique INRIA FR 34 Institut Pasteur IP FR 35 Johann Wolfgang Goethe Universität Frankfurt am Main UFRA DE 36 Karlsruher Institut für Technologie KIT DE 37 Karolinska Institutet KI SE 38 King's College London KCL GB 39 Kungliga Tekniska Hoegskolan KTH SE 40 Laboratorio Europeo di Spettroscopie Non Lineari LENS IT 41 Linneuniversitetet LNU SE 42 Medizinische Universität Innsbruck MUI AT 43 Ethniko Kai Kapodistriako Panepistimio Athinon UoA GR HBP FPA Amendment 1 RE = Restricted 28 June 2016 Page 1 / 384 Co-funded by the European Union 44 Norges miljø- og biovitenskapelige universitet NMBU NO 45 Österreichische Studiengesellschaft für Kybernetik OFAI AT 46 Rheinisch-Westfälische Technische Hochschule Aachen RWTH DE 47 Ruprecht-Karls-Universität Heidelberg UHEI DE 48 Sabancı Üniversitesi SU TR 49 Scuola Superiore di Studi Universitari e di Perfezionamento Sant'Anna SSSA IT 50 Centrum voor Wiskunde en Informatica CWI NL 51 Stichting Katholieke Universiteit SKU NL 52 Stiftung FZI Forschungszentrum Informatik am Karlsruher Institut für Technologie FZI DE 53 Technical University of Crete TUC GR 54 Technische Universität Dresden TUD DE 55 Technische Universität Graz TUGRAZ AT 56 Technische Universität München TUM DE 57 Tel Aviv University TAU IL 58 (blank) 59 The Chancellor, Masters and Scholars of the University of Oxford UOXF GB 60 The Hebrew University of Jerusalem HUJI IL 61 The University Court of the University of Aberdeen UABER GB 62 University of Edinburgh UEDIN GB 63 University of Manchester UMAN GB 64 Universidad Autonoma de Madrid UAM ES 65 Universidad de Castilla - La Mancha UCLM ES 66 Universidad de Granada UGR ES 67 Universidade Do Minho UMIHNO PT 68 Universidad Politécnica de Madrid UPM ES 69 Universidad Rey Juan Carlos URJC ES 70 Universita degli Studi di Pavia UNIPV IT 71 Universität Bern UBERN CH 72 Universität Bielefeld UNIBI DE 73 Universitätsklinikum Aachen UKAACHEN DE 74 Universitätsklinikum Hamburg-Eppendorf UKE DE 75 Universität Zürich UZH CH 76 Universitat de Barcelona UB ES 77 Universitat Pompeu Fabra UPF ES 78 Université d’Aix Marseille AMU FR 79 Université Victor Segalen Bordeaux II UBO FR 80 Universiteit Antwerpen UA BE 81 Universitetet i Oslo UiO NO 82 University College London UCL GB 83 Uppsala Universitet UU SE 84 Weizmann Institute of Science WEIZMANN IL 85 Technische Universität Darmstadt TUDA DE 86 Université de Genève UNIGE CH 87 Consorci Institut d'Investigacions Biomediques August Pi i Sunyer IDIBAPS ES 88 Fundacio Institut de Bioenginyeria de Catalunya IBEC ES 89 Deutsches Zentrum fuer Neurodegenerative Erkrankungen EV DZNE DE 90 Humboldt-Universitaet zu Berlin UBER DE HBP FPA Amendment 1 RE = Restricted 28 June 2016 Page 2 / 384 Co-funded by the European Union 91 Istituto Nazionale di Fisica Nucleare INFN IT 92 Istituto Superiore di Sanità ISS IT 93 Koninklijke Nederlandse Akademie van Wetenschappen – Knaw KNAW NL 94 Medical Research Council MRC GB 95 Universita Degli Studi Di Milano UMIL IT 96 Université de Liege ULG BE 97 Universiteit van Amsterdam UvA NL 98 University of Glasgow UGLA GB 99 University of Hamburg UHAM DE 100 University of Sheffield USFD GB 101 University of the West of England, Bristol UWE GB 102 University of Surrey SURREY GB 103 TTY-Saatio TUT FI 104 University of Leeds ULEEDS UK 105 Université Pierre et Marie Curie - Paris 6 UPMC FR 106 University of Sussex UoS UK 107 Middlesex University Higher Education Corporation MU GB 108 Université Lyon 1 Claude Bernard UCBL FR 109 Politecnico di Torino POLITO IT 110 Universiteit Gent UGENT BE 111 Katholieke Universiteit Leuven KUL BE 112 Universitaet Basel UNIBAS CH 113 Stichting VU-VUmc VU NL 114 Institut Suisse de Bioinformatiquefondation ISB SIB CH 115 European Brain Research Institute Rita Levi-Montalcini Fondazione*EBRI EBRI IT 116 Scuola Normale Superiore SNS IT 117 Universiteit Maastricht UM NL Table 1: List of Partners in HBP Core Project at start of the FPA Table of Contents 2.1 Excellence ..................................................................................................... 9 2.1.0 Background and Context ............................................................................ 9 2.1.1 Concept and Objectives ............................................................................. 9 2.2 Impact ......................................................................................................... 24 2.2.1 Expected Impact ..................................................................................... 24 2.2.2 Measures to maximise impact ..................................................................... 29 2.3 Implementation .............................................................................................. 51 2.3.1 Work Plan ............................................................................................. 51 2.3.2 Management structures and procedures ......................................................... 77 2.3.3 Planned use of resources ......................................................................... 110 2.4 Consortium ................................................................................................. 121 2.4.1 Consortium as a whole............................................................................ 121 2.4.2 Capacity of participants and links to third parties ........................................... 127 2.5 Responsible Research and Innovation .................................................................. 128 2.5.1 Ethics Issues and Related Measures ............................................................ 128 2.5.2 Coverage of EC Ethics Requirements ........................................................... 143 Appendix 1: Overview of the Flagship Objectives and Strategic Research Roadmap .. 149 A1.1 Concept and Strategy...................................................................................... 149 A1.2 Flagship Objectives (FOs) ................................................................................. 151 HBP FPA Amendment 1 RE = Restricted 28 June 2016 Page 3 / 384 Co-funded by the European Union A1.3. Research Roadmap ........................................................................................ 152 A1.4 Subproject 1: Mouse Brain Organisation ................................................................ 154 A1.4.1 SP1: General Objectives .......................................................................... 154 A1.4.2 SP1: State of the Art .............................................................................. 156 A1.4.3 SP1: Advances over State of the Art ........................................................... 157 A1.4.4 SP1: Operational Objectives ..................................................................... 158 A1.4.5 SP1: Main Objectives / Deliverables per SGA ................................................. 159 A1.4.6 SP1: Collaborations with other National, European and International Initiatives ....... 160 A1.4.7 SP1: Impact and Innovation Potential .......................................................... 160 A1.5 Subproject 2: Human Brain Organisation ............................................................... 161 A1.5.1 SP2: General Objectives .......................................................................... 161 A1.5.2 SP2: State of the Art .............................................................................. 162 A1.5.3 SP2: Advances over State of the Art ........................................................... 163 A1.5.4 SP2: Operational Objectives ..................................................................... 164 A1.5.5 SP2: Main Objectives / Deliverables per SGA ................................................. 166 A1.5.6 SP2: Collaborations