Inheritance of Beta-Carotene in Tomatoes' Eta
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Journal of Nephropathology
View metadata, citation and similar papers at core.ac.uk brought to you by CORE provided by shahrekord university of medical scinces www.nephropathol.com DOI: 10.15171/jnp.2017.25 J Nephropathol. 2017;6(3):144-149 Journal of Nephropathology Ameliorative effect of lycopene effect on cisplatin-induced nephropathy in patients Leila Mahmoodnia, Keivan Mohammadi*, Rohollah Masumi Department of Internal Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran ARTICLE INFO ABSTRACT Article type: Background: Nephrotoxicity is one of the most important limitations of cisplatin-based Original Article chemotherapies which associated with many complications and high mortality rate. Objectives: To investigate the effect of lycopene on cisplatin-induced nephrotoxicity in Article history: patients with cancer. Received: 14 November 2016 Accepted: 2 January 2017 Patients and Methods: In this double-blind, randomized clinical trial, 120 patients were Published online: 17 January 2017 randomly assigned to two groups, case (treated with lycopene + standard regimen of kidney DOI: 10.15171/jnp.2017.25 injury prevention) and control (treated with only the standard regimen of kidney injury prevention). Lycopene was orally taken from 24 hours before to 72 hours after cisplatin Keywords: administration. Blood urea nitrogen (BUN), serum creatinine (Cr), and glomerular Lycopene filtration rate (GFR) were measured and recorded. The data were analyzed using SPSS. Nephrotoxicity Results: Changes in Cr were not significantly different between the two groups (P = 0.131). Cisplatin However, a significant decreasing trend was seen in GFR during the study, which was Cancer more marked in the control group (P = 0.004). BUN significantly decreased during the Original Article study (P = 0.002), and a significant decrease of BUN on the day three in both groups was seen (P = 0.001). -
Efficient Production of Saffron Crocins and Picrocrocin in Nicotiana Benthamiana Using a Virus-Driven System
Metabolic Engineering 61 (2020) 238–250 Contents lists available at ScienceDirect Metabolic Engineering journal homepage: www.elsevier.com/locate/meteng Efficient production of saffron crocins and picrocrocin in Nicotiana benthamiana using a virus-driven system Maricarmen Martí a,1, Gianfranco Diretto b,1, Veronica� Aragones� a, Sarah Frusciante b, Oussama Ahrazem c, Lourdes Gomez-G� omez� c,**, Jose-Antonio� Daros� a,* a Instituto de Biología Molecular y Celular de Plantas (Consejo Superior de Investigaciones Científicas-Universitat Polit�ecnica de Val�encia), 46022, Valencia, Spain b Italian National Agency for New Technologies, Energy, and Sustainable Development, Casaccia Research Centre, 00123, Rome, Italy c Instituto Botanico,� Departamento de Ciencia y Tecnología Agroforestal y Gen�etica, Facultad de Farmacia, Universidad de Castilla-La Mancha, Campus Universitario S/ n, 02071, Albacete, Spain ARTICLE INFO ABSTRACT Keywords: Crocins and picrocrocin are glycosylated apocarotenoids responsible, respectively, for the color and the unique Apocarotenoids taste of the saffron spice, known as red gold due to its high price. Several studies have also shown the health- Crocins promoting properties of these compounds. However, their high costs hamper the wide use of these metabo Picrocrocin lites in the pharmaceutical sector. We have developed a virus-driven system to produce remarkable amounts of Carotenoid cleavage dioxygenase crocins and picrocrocin in adult Nicotiana benthamiana plants in only two weeks. The system consists of viral Viral vector Tobacco etch virus clones derived from tobacco etch potyvirus that express specificcarotenoid cleavage dioxygenase (CCD) enzymes Potyvirus from Crocus sativus and Buddleja davidii. Metabolic analyses of infected tissues demonstrated that the sole virus- driven expression of C. -
Meet Lycopene Prostate Cancer Is One of the Leading Causes of Cancer Death Among Men in the United States
UCLA Nutrition Noteworthy Title Lycopene and Mr. Prostate: Best Friends Forever Permalink https://escholarship.org/uc/item/5ks510rw Journal Nutrition Noteworthy, 5(1) Author Simzar, Soheil Publication Date 2002 Peer reviewed eScholarship.org Powered by the California Digital Library University of California Meet Lycopene Prostate cancer is one of the leading causes of cancer death among men in the United States. Dietary factors are considered an important risk factor for the development of prostate cancer in addition to age, genetic predisposition, environmental factors, and other lifestyle factors such as smoking. Recent studies have indicated that there is a direct correlation between the occurrence of prostate cancer and the consumption of tomatoes and tomato-based products. Lycopene, one of over 600 carotenoids, is one of the main carotenoids found in human plasma and it is responsible for the red pigment found in tomatoes and other foods such as watermelons and red grapefruits. It has been shown to be a very potent antioxidant, with oxygen-quenching ability greater than any other carotenoid. Recent research has indicated that its antioxidant effects help lower the risk of heart disease, atherosclerosis, and different types of cancer-especially prostate cancer. Lycopene's Characteristics Lycopene is on of approximately 600 known carotenoids. Carotenoids are red, yellow, and orange pigments which are widely distributed in nature and are especially abundant in yellow- orange fruits and vegetables and dark green, leafy vegetables. They absorb light in the 400- 500nm region which gives them a red/yellow color. Only green plants and certain microorganisms such as fungi and algae can synthesize these pigments. -
Lycopene Analysis and Horticultural Attributes of Tomatoes. MS Thesis
THESIS LYCOPENE ANALYSIS AND HORTICULTURAL ATTRIBUTES OF TOMATOES Submitted by Samuel E. Cox Department of Horticulture In partial fulfillment of the requirements for the Degree of Master of Science Colorado State University Fort Collins, Colorado Spring 2001 COLORADO STATE UNIVERSITY March 9, 2001 WE HEREBY RECOMMEND THAT THE THESIS PREPARED UNDER OUR SUPERVISION BY SAMUEL E. COX ENTITLED LYCOPENE ANALYSIS AND HORTICULTURAL ATTRIBUTES OF TOMATOES BE ACCEPTED AS FULFILLING IN PART REQUIREMENTS FOR THE DEGREE OF MASTER OF SCIENCE Committee on Graduate Work Michelle L. Jones David A. Sampson Cecil Stushnoff Advisor Steve Wallner Department Head ii THESIS ABSTRACT LYCOPENE ANALYSIS AND HORTICULTURAL ATTRIBUTES OF TOMATOES Tomatoes are the most popular home garden vegetables grown in the United States, and have one of the highest value/acre ratios of any commercially produced crop. Popularity of tomatoes, combined with competition among seed companies, have led to an abundance and often bewildering variety of cultivars intended for home garden cultivation. Thirty home garden cultivars marketed at local nurseries in northern Colorado were grown and evaluated. Plant health, morphology and size, subjective plant yield observations and objective taste measurements were all investigated in order to identify exceptional or unacceptable cultivars for this area. Cellular damage from free radicals is a major cause of degenerative diseases and cancer. Lycopene is an open-chain hydrocarbon carotenoid found in abundance in tomatoes that has been shown to possess strong antioxidant activity in animal systems. This led to the discovery that several types of cancers are inhibited by its consumption. Research into the properties and health benefits of lycopene has been a relatively recent development and will undoubtedly continue to grow. -
Tanibirumab (CUI C3490677) Add to Cart
5/17/2018 NCI Metathesaurus Contains Exact Match Begins With Name Code Property Relationship Source ALL Advanced Search NCIm Version: 201706 Version 2.8 (using LexEVS 6.5) Home | NCIt Hierarchy | Sources | Help Suggest changes to this concept Tanibirumab (CUI C3490677) Add to Cart Table of Contents Terms & Properties Synonym Details Relationships By Source Terms & Properties Concept Unique Identifier (CUI): C3490677 NCI Thesaurus Code: C102877 (see NCI Thesaurus info) Semantic Type: Immunologic Factor Semantic Type: Amino Acid, Peptide, or Protein Semantic Type: Pharmacologic Substance NCIt Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor tyrosine kinase expressed by endothelial cells, while VEGF is overexpressed in many tumors and is correlated to tumor progression. PDQ Definition: A fully human monoclonal antibody targeting the vascular endothelial growth factor receptor 2 (VEGFR2), with potential antiangiogenic activity. Upon administration, tanibirumab specifically binds to VEGFR2, thereby preventing the binding of its ligand VEGF. This may result in the inhibition of tumor angiogenesis and a decrease in tumor nutrient supply. VEGFR2 is a pro-angiogenic growth factor receptor -
Carotene and Lycopene Isoforms, and of Antioxidant Potential in Human Blood Bioavailability: a Pilot Study
nutrients Article Nutritional Controlled Preparation and Administration of Different Tomato Purées Indicate Increase of β-Carotene and Lycopene Isoforms, and of Antioxidant Potential in Human Blood Bioavailability: A Pilot Study Daniela Vitucci 1,†, Angela Amoresano 2,†, Marcella Nunziato 1,3,† , Simona Muoio 4, Andreina Alfieri 1,5 , Giovannangelo Oriani 1, Luca Scalfi 6, Luigi Frusciante 7, Maria Manuela Rigano 7 , Piero Pucci 1,2, Luigi Fontana 8,9,10, Pasqualina Buono 1,5,* and Francesco Salvatore 1,3,* 1 CEINGE-Biotecnologie Avanzate, Via G. Salvatore, 486, 80145 Naples, Italy; [email protected] (D.V.); [email protected] (M.N.); andreina.alfi[email protected] (A.A.); [email protected] (G.O.); [email protected] (P.P.) 2 Department of Chemical Sciences, University of Naples “Federico II”, Via Cinthia, 80126 Naples, Italy; [email protected] 3 Department of Molecular Medicine and Medical Biotechnologies, University of Naples “Federico II”, Via Sergio Pansini 5, 80131 Naples, Italy 4 Department of Public Health, School of Medicine, University of Naples “Federico II”, 80131 Naples, Italy; [email protected] 5 Department of Human Movement Sciences and Wellbeing, University of Naples “Parthenope”, Via Medina, Citation: Vitucci, D.; Amoresano, A.; 40, 80133 Naples, Italy Nunziato, M.; Muoio, S.; Alfieri, A.; 6 Institute of Internal Medicine and Metabolic Diseases, Medical School, University of Naples, Federico II, Oriani, G.; Scalfi, L.; Frusciante, L.; 80131 Naples, Italy; scalfi@unina.it Rigano, M.M.; Pucci, P.; et al. 7 Department -
Simultaneous Dissection of Grain Carotenoid Levels and Kernel Color in Biparental Maize Populations with Yellow-To-Orange Grain
bioRxiv preprint doi: https://doi.org/10.1101/2021.09.01.458275; this version posted September 3, 2021. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted bioRxiv a license to display the preprint in perpetuity. It is made available under aCC-BY-NC-ND 4.0 International license. TITLE: Simultaneous Dissection of Grain Carotenoid Levels and Kernel Color in Biparental Maize Populations with Yellow-to-Orange Grain AUTHORS AND ADDRESSES: Mary-Francis LaPorte1, Mishi Vachev1†, Matthew Fenn2†, Christine Diepenbrock1* 1University of California, Davis, Department of Plant Sciences, Davis, CA 95616. 2Cornell University, Plant Breeding and Genetics Section, School of Integrative Plant Science, Ithaca, NY 14853. †Indicates equal contribution. *For correspondence: [email protected], +1(530)754-0666. ABSTRACT: Maize enriched in provitamin A carotenoids could be key in combatting vitamin A deficiency in human populations relying on maize as a food staple. Consumer studies indicate that orange maize may be regarded as novel and preferred. This study identifies genes of relevance for grain carotenoid concentrations and kernel color, through simultaneous dissection of these traits in 10 families of the U.S. maize nested association mapping population that have yellow to orange grain. Quantitative trait loci (QTL) were identified via joint-linkage analysis, with phenotypic variation explained for individual kernel color QTL ranging from 2.4 to 17.5%. These QTL were cross-analyzed with significant marker-trait associations in a genome-wide association study that utilized ~27 million variants. Nine genes were identified: four encoding activities upstream of the core carotenoid pathway, one at the pathway branchpoint, three within the α- or β-pathway branches, and one encoding a carotenoid cleavage dioxygenase. -
Genetic Modification of Tomato with the Tobacco Lycopene Β-Cyclase Gene Produces High Β-Carotene and Lycopene Fruit
Z. Naturforsch. 2016; 71(9-10)c: 295–301 Louise Ralley, Wolfgang Schucha, Paul D. Fraser and Peter M. Bramley* Genetic modification of tomato with the tobacco lycopene β-cyclase gene produces high β-carotene and lycopene fruit DOI 10.1515/znc-2016-0102 and alleviation of vitamin A deficiency by β-carotene, Received May 18, 2016; revised July 4, 2016; accepted July 6, 2016 which is pro-vitamin A [4]. Deficiency of vitamin A causes xerophthalmia, blindness and premature death, espe- Abstract: Transgenic Solanum lycopersicum plants cially in children aged 1–4 [5]. Since humans cannot expressing an additional copy of the lycopene β-cyclase synthesise carotenoids de novo, these health-promoting gene (LCYB) from Nicotiana tabacum, under the control compounds must be taken in sufficient quantities in the of the Arabidopsis polyubiquitin promoter (UBQ3), have diet. Consequently, increasing their levels in fruit and been generated. Expression of LCYB was increased some vegetables is beneficial to health. Tomato products are 10-fold in ripening fruit compared to vegetative tissues. the most common source of dietary lycopene. Although The ripe fruit showed an orange pigmentation, due to ripe tomato fruit contains β-carotene, the amount is rela- increased levels (up to 5-fold) of β-carotene, with negli- tively low [1]. Therefore, approaches to elevate β-carotene gible changes to other carotenoids, including lycopene. levels, with no reduction in lycopene, are a goal of Phenotypic changes in carotenoids were found in vegeta- plant breeders. One strategy that has been employed to tive tissues, but levels of biosynthetically related isopre- increase levels of health promoting carotenoids in fruits noids such as tocopherols, ubiquinone and plastoquinone and vegetables for human and animal consumption is were barely altered. -
Enhanced Lycopene Production in Escherichia Coli by Expression of Two MEP Pathway Enzymes from Vibrio Sp
catalysts Article Enhanced Lycopene Production in Escherichia coli by Expression of Two MEP Pathway Enzymes from Vibrio sp. Dhg 1, 1, 1 1, Min Jae Kim y, Myung Hyun Noh y , Sunghwa Woo , Hyun Gyu Lim * and Gyoo Yeol Jung 1,2,* 1 Department of Chemical Engineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Korea; [email protected] (M.J.K.); [email protected] (M.H.N.); [email protected] (S.W.) 2 School of Interdisciplinary Bioscience and Bioengineering, Pohang University of Science and Technology, 77 Cheongam-Ro, Nam-Gu, Pohang, Gyeongbuk 37673, Korea * Correspondence: [email protected] (H.G.L.); [email protected] (G.Y.J.); Tel.: +82-54-279-2391 (G.Y.J.) These authors contributed equally to this work. y Received: 28 October 2019; Accepted: 26 November 2019; Published: 29 November 2019 Abstract: Microbial production is a promising method that can overcome major limitations in conventional methods of lycopene production, such as low yields and variations in product quality. Significant efforts have been made to improve lycopene production by engineering either the 2-C-methyl-d-erythritol 4-phosphate (MEP) pathway or mevalonate (MVA) pathway in microorganisms. To further improve lycopene production, it is critical to utilize metabolic enzymes with high specific activities. Two enzymes, 1-deoxy-d-xylulose-5-phosphate synthase (Dxs) and farnesyl diphosphate synthase (IspA), are required in lycopene production using MEP pathway. Here, we evaluated the activities of Dxs and IspA of Vibrio sp. dhg, a newly isolated and fast-growing microorganism. -
Evaluating the Presence of Lycopene-Enriched Extracts from Tomato on Topical Emulsions: Physico-Chemical Characterization and Sensory Analysis
applied sciences Article Evaluating the Presence of Lycopene-Enriched Extracts from Tomato on Topical Emulsions: Physico-Chemical Characterization and Sensory Analysis Ana Costa 1,*,†, Marta Marques 2,† , Franca Congiu 1, Alexandre Paiva 2 , Pedro Simões 2 , António Ferreira 3, Maria Rosário Bronze 1,3 , Joana Marto 1 , Helena Margarida Ribeiro 1,* and Sandra Simões 1 1 iMed.ULisboa, Faculty of Pharmacy, Universidade de Lisboa, Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal; [email protected] (F.C.); [email protected] (M.R.B.); [email protected] (J.M.); [email protected] (S.S.) 2 LAQV-REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Quinta da Torre, 2829-516 Caparica, Portugal; [email protected] (M.M.); [email protected] (A.P.); [email protected] (P.S.) 3 IBET, Instituto de Biologia Experimental e Tecnológica, Av. da República, Estação Agronómica, Apartado 12, 2780-901 Oeiras, Portugal; [email protected] * Correspondence: [email protected] (A.C.); [email protected] (H.M.R.) † The two authors contributed equally to this work. Abstract: One of the new trends of personal care industry is the use of organic ingredients de- Citation: Costa, A.; Marques, M.; rived from nature, in particular, from food-processing residues with proven efficacy. Lycopene Congiu, F.; Paiva, A.; Simões, P.; is a carotenoid responsible for the red color of several fruits, namely tomato, whose antioxidant Ferreira, A.; Bronze, M.R.; Marto, J.; and photoprotective effects have been studied. Methods: Lycopene-enriched extracts (LEE) were Ribeiro, H.M.; Simões, S. -
Vitamins a and E and Carotenoids
Fat-Soluble Vitamins & Micronutrients: Vitamins A and E and Carotenoids Vitamins A (retinol) and E (tocopherol) and the carotenoids are fat-soluble micronutrients that are found in many foods, including some vegetables, fruits, meats, and animal products. Fish-liver oils, liver, egg yolks, butter, and cream are known for their higher content of vitamin A. Nuts and seeds are particularly rich sources of vitamin E (Thomas 2006). At least 700 carotenoids—fat-soluble red and yellow pigments—are found in nature (Britton 2004). Americans consume 40–50 of these carotenoids, primarily in fruits and vegetables (Khachik 1992), and smaller amounts in poultry products, including egg yolks, and in seafoods (Boylston 2007). Six major carotenoids are found in human serum: alpha-carotene, beta-carotene, beta-cryptoxanthin, lutein, trans-lycopene, and zeaxanthin. Major carotene sources are orange-colored fruits and vegetables such as carrots, pumpkins, and mangos. Lutein and zeaxanthin are also found in dark green leafy vegetables, where any orange coloring is overshadowed by chlorophyll. Trans-Lycopene is obtained primarily from tomato and tomato products. For information on the carotenoid content of U.S. foods, see the 1998 carotenoid database created by the U.S. Department of Agriculture and the Nutrition Coordinating Center at the University of Minnesota (http://www.nal.usda.gov/fnic/foodcomp/Data/car98/car98.html). Vitamin A, found in foods that come from animal sources, is called preformed vitamin A. Some carotenoids found in colorful fruits and vegetables are called provitamin A; they are metabolized in the body to vitamin A. Among the carotenoids, beta-carotene, a retinol dimer, has the most significant provitamin A activity. -
Free Radicals in Biology and Medicine Page 0
77:222 Spring 2005 Free Radicals in Biology and Medicine Page 0 This student paper was written as an assignment in the graduate course Free Radicals in Biology and Medicine (77:222, Spring 2005) offered by the Free Radical and Radiation Biology Program B-180 Med Labs The University of Iowa Iowa City, IA 52242-1181 Spring 2005 Term Instructors: GARRY R. BUETTNER, Ph.D. LARRY W. OBERLEY, Ph.D. with guest lectures from: Drs. Freya Q . Schafer, Douglas R. Spitz, and Frederick E. Domann The Fine Print: Because this is a paper written by a beginning student as an assignment, there are no guarantees that everything is absolutely correct and accurate. In view of the possibility of human error or changes in our knowledge due to continued research, neither the author nor The University of Iowa nor any other party who has been involved in the preparation or publication of this work warrants that the information contained herein is in every respect accurate or complete, and they are not responsible for any errors or omissions or for the results obtained from the use of such information. Readers are encouraged to confirm the information contained herein with other sources. All material contained in this paper is copyright of the author, or the owner of the source that the material was taken from. This work is not intended as a threat to the ownership of said copyrights. S. Jetawattana Lycopene, a powerful antioxidant 1 Lycopene, a powerful antioxidant by Suwimol Jetawattana Department of Radiation Oncology Free Radical and Radiation Biology The University