THAP1 Conjugated Antibody

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Product Datasheet THAP1 Conjugated Antibody Catalog No: #C48420 Package Size: #C48420-AF350 100ul #C48420-AF405 100ul #C48420-AF488 100ul Orders: [email protected] Support: [email protected] #C48420-AF555 100ul #C48420-AF594 100ul #C48420-AF647 100ul #C48420-AF680 100ul #C48420-AF750 100ul #C48420-Biotin 100ul Description Product Name THAP1 Conjugated Antibody Host Species Mouse Clonality Monoclonal Species Reactivity Hu Immunogen Description Recombinant protein Conjugates Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750 Other Names 4833431A01Rik antibody DYT6 antibody FLJ10477 antibody MGC33014 antibody Nuclear proapoptotic factor antibody THAP 1 antibody THAP domain containing 1 antibody THAP domain containing apoptosis associated protein 1 antibody THAP domain containing protein 1 antibody THAP domain protein 1 antibody THAP domain-containing protein 1 antibody Thap1 antibody THAP1_HUMAN antibody Accession No. Swiss-Prot#:Q9NVV9 Calculated MW 25 kDa Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide Storage Store at 4°C in dark for 6 months Application Details Suggested Dilution: AF350 conjugated: most applications: 1: 50 - 1: 250 AF405 conjugated: most applications: 1: 50 - 1: 250 AF488 conjugated: most applications: 1: 50 - 1: 250 AF555 conjugated: most applications: 1: 50 - 1: 250 AF594 conjugated: most applications: 1: 50 - 1: 250 AF647 conjugated: most applications: 1: 50 - 1: 250 AF680 conjugated: most applications: 1: 50 - 1: 250 AF750 conjugated: most applications: 1: 50 - 1: 250 Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000 Background THAP1 (THAP domain containing, apoptosis associated protein 1) is a 213 amino acid protein that localizes to the nucleoplasm and contains one THAP-type zinc finger, a conserved DNA-binding domain. Interacting with PAR4, THAP1 functions as a pro-apoptotic protein that acts in a zinc-dependent manner and enhances the likelihood of both TNF- and serum withdrawal-induced apoptosis, possibly playing a role in promyelocytic leukemia. The gene encoding THAP1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 1 chromosome 8. Note: This product is for in vitro research use only and is not intended for use in humans or animals. Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 2.

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A Computational Approach for Defining a Signature of Β-Cell Golgi Stress in Diabetes Mellitus
Page 1 of 781 Diabetes A Computational Approach for Defining a Signature of β-Cell Golgi Stress in Diabetes Mellitus Robert N. Bone1,6,7, Olufunmilola Oyebamiji2, Sayali Talware2, Sharmila Selvaraj2, Preethi Krishnan3,6, Farooq Syed1,6,7, Huanmei Wu2, Carmella Evans-Molina 1,3,4,5,6,7,8* Departments of 1Pediatrics, 3Medicine, 4Anatomy, Cell Biology & Physiology, 5Biochemistry & Molecular Biology, the 6Center for Diabetes & Metabolic Diseases, and the 7Herman B. Wells Center for Pediatric Research, Indiana University School of Medicine, Indianapolis, IN 46202; 2Department of BioHealth Informatics, Indiana University-Purdue University Indianapolis, Indianapolis, IN, 46202; 8Roudebush VA Medical Center, Indianapolis, IN 46202. *Corresponding Author(s): Carmella Evans-Molina, MD, PhD ([email protected]) Indiana University School of Medicine, 635 Barnhill Drive, MS 2031A, Indianapolis, IN 46202, Telephone: (317) 274-4145, Fax (317) 274-4107 Running Title: Golgi Stress Response in Diabetes Word Count: 4358 Number of Figures: 6 Keywords: Golgi apparatus stress, Islets, β cell, Type 1 diabetes, Type 2 diabetes 1 Diabetes Publish Ahead of Print, published online August 20, 2020 Diabetes Page 2 of 781 ABSTRACT The Golgi apparatus (GA) is an important site of insulin processing and granule maturation, but whether GA organelle dysfunction and GA stress are present in the diabetic β-cell has not been tested. We utilized an informatics-based approach to develop a transcriptional signature of β-cell GA stress using existing RNA sequencing and microarray datasets generated using human islets from donors with diabetes and islets where type 1(T1D) and type 2 diabetes (T2D) had been modeled ex vivo. To narrow our results to GA-specific genes, we applied a filter set of 1,030 genes accepted as GA associated.
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Structural Basis for the Regulatory Interactions of Proapoptotic Par-4
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DNABERT: Pre-Trained Bidirectional Encoder Representations from Transformers Model for DNA-Language in Genome
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Tan et al. Cancer Cell Int (2020) 20:598 https://doi.org/10.1186/s12935-020-01704-y Cancer Cell International PRIMARY RESEARCH Open Access Expression of PAWR predicts prognosis of ovarian cancer Jiahong Tan1,2, Kangjia Tao1,2, Xu Zheng1,2, Dan Liu1,2, Ding Ma1,2 and Qinglei Gao1,2* Abstract Background: Ovarian cancer greatly threatens the general health of women worldwide. Implementation of predic- tive prognostic biomarkers aids in ovarian cancer management. Methods: Using online databases, the general expression profle, target-disease associations, and interaction net- work of PAWR were explored. To identify the role of PAWR in ovarian cancer, gene correlation analysis, survival analysis, and combined analysis of drug responsiveness and PAWR expression were performed. The predictive prognostic value of PAWR was further validated in clinical samples. Results: PAWR was widely expressed in normal and cancer tissues, with decreased expression in ovarian cancer tissues compared with normal tissues. PAWR was associated with various cancers including ovarian cancer. PAWR formed a regulatory network with a group of proteins and correlated with several genes, which were both implicated in ovarian cancer and drug responsiveness. High PAWR expression denoted better survival in ovarian cancer patients (OS: HR 0.84, P 0.0077; PFS, HR 0.86, P 0.049). Expression of PAWR could predict platinum responsiveness in ovarian =cancer and= there was a positive= correlation= between PAWR gene efect and paclitaxel sensitivity. In 12 paired clinical samples, the cancerous tissues exhibited signifcantly lower PAWR expression than matched normal fallopian tubes. The predictive prognostic value of PAWR was maintained in a cohort of 50 ovarian cancer patients.
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Downloaded from molpharm.aspetjournals.org at ASPET Journals on September 28, 2021 1 This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted. The final version may differ from this version. This article has not been copyedited and formatted.
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Investigating the Effects of Chronic Perinatal Alcohol and Combined
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BT-CSC Dznep Treated Up-Regulated Genes Gene Symbol Gene Name M
BT-CSC DZNep treated up-regulated genes Gene Symbol Gene Name M Value KRTAP19-1 keratin associated protein 19-1 5.091638802 VPS53 vacuolar protein sorting 53 homolog (S. cerevisiae) 4.920143235 HEATR2 HEAT repeat containing 2 4.545255947 BRAF v-raf murine sarcoma viral oncogene homolog B1 4.404531741 PCDH7 protocadherin 7 4.378536321 PRKACB protein kinase, cAMP-dependent, catalytic, beta 4.337185544 C6orf166 chromosome 6 open reading frame 166 4.244909909 HIST1H3H histone cluster 1, H3h 4.085723721 CRAMP1L Crm, cramped-like (Drosophila) 3.811674874 RPS15 ribosomal protein S15 3.776296646 EPPK1 epiplakin 1 3.724368921 LAMA4 laminin, alpha 4 3.634864123 SEMA3C sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C 3.504490549 MALAT1 metastasis associated lung adenocarcinoma transcript 1 (non-protein coding) 3.3915307 EPC1 enhancer of polycomb homolog 1 (Drosophila) 3.37404925 ANKRD13C ankyrin repeat domain 13C 3.367543301 HIST2H2BE histone cluster 2, H2be 3.331087945 LOC158301 hypothetical protein LOC158301 3.328891352 LOC56755 hypothetical protein LOC56755 3.233203867 HEXIM1 hexamethylene bis-acetamide inducible 1 3.231227044 SYT11 synaptotagmin XI 3.217641148 KRTAP7-1 keratin associated protein 7-1 3.202664068 TEX14 testis expressed 14 3.19144479 TUG1 taurine upregulated gene 1 3.15045817 KLHL28 kelch-like 28 (Drosophila) 3.074070618 KRTAP19-3 keratin associated protein 19-3 3.056583425 DOCK1 dedicator of cytokinesis 1 3.053526521 NHEDC1 Na+/H+ exchanger domain containing 1 3.013610505 SFN stratifin 3.000939496
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