Product Datasheet THAP1 Conjugated Antibody Catalog No: #C48420 Package Size: #C48420-AF350 100ul #C48420-AF405 100ul #C48420-AF488 100ul Orders: [email protected] Support: [email protected] #C48420-AF555 100ul #C48420-AF594 100ul #C48420-AF647 100ul #C48420-AF680 100ul #C48420-AF750 100ul #C48420-Biotin 100ul Description Product Name THAP1 Conjugated Antibody Host Species Mouse Clonality Monoclonal Species Reactivity Hu Immunogen Description Recombinant protein Conjugates Biotin AF350 AF405 AF488 AF555 AF594 AF647 AF680 AF750 Other Names 4833431A01Rik antibody DYT6 antibody FLJ10477 antibody MGC33014 antibody Nuclear proapoptotic factor antibody THAP 1 antibody THAP domain containing 1 antibody THAP domain containing apoptosis associated protein 1 antibody THAP domain containing protein 1 antibody THAP domain protein 1 antibody THAP domain-containing protein 1 antibody Thap1 antibody THAP1_HUMAN antibody Accession No. Swiss-Prot#:Q9NVV9 Calculated MW 25 kDa Formulation 0.01M Sodium Phosphate, 0.25M NaCl, pH 7.6, 5mg/ml Bovine Serum Albumin, 0.02% Sodium Azide Storage Store at 4°C in dark for 6 months Application Details Suggested Dilution: AF350 conjugated: most applications: 1: 50 - 1: 250 AF405 conjugated: most applications: 1: 50 - 1: 250 AF488 conjugated: most applications: 1: 50 - 1: 250 AF555 conjugated: most applications: 1: 50 - 1: 250 AF594 conjugated: most applications: 1: 50 - 1: 250 AF647 conjugated: most applications: 1: 50 - 1: 250 AF680 conjugated: most applications: 1: 50 - 1: 250 AF750 conjugated: most applications: 1: 50 - 1: 250 Biotin conjugated: working with enzyme-conjugated streptavidin, most applications: 1: 50 - 1: 1,000 Background THAP1 (THAP domain containing, apoptosis associated protein 1) is a 213 amino acid protein that localizes to the nucleoplasm and contains one THAP-type zinc finger, a conserved DNA-binding domain. Interacting with PAR4, THAP1 functions as a pro-apoptotic protein that acts in a zinc-dependent manner and enhances the likelihood of both TNF- and serum withdrawal-induced apoptosis, possibly playing a role in promyelocytic leukemia. The gene encoding THAP1 maps to human chromosome 8, which consists of nearly 146 million base pairs, houses more than 800 genes and is associated with a variety of diseases and malignancies. Schizophrenia, bipolar disorder, Trisomy 8, Pfeiffer syndrome, congenital hypothyroidism, Waardenburg syndrome and some leukemias and lymphomas are thought to occur as a result of defects in specific genes that map to Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 1 chromosome 8. Note: This product is for in vitro research use only and is not intended for use in humans or animals. Address: 8400 Baltimore Ave., Suite 302, College Park, MD 20740, USA http://www.sabbiotech.com 2.