Nootropics - Smart Drugs Cheat Sheet by [Deleted] Via Cheatography.Com/8051/Cs/1179

Nootropics - Smart Drugs Cheat Sheet by [deleted] via cheatography.com/8051/cs/1179/

Nootropics Dictionary (cont) Dictionary (cont)

Giurg ea's Nootropic Criteri a: Neur‐ Chemical released by neurons to Ago A chemical substance (as a drug) Enhances learning and memory. otr‐ stimulate neighbo uring neurons, ni st capable of combining with a Enhances learned behaviors under ans‐ allowing impulses to be passed receptor on a cell and initiating the conditions which are known to disrupt mit‐ from one cell to the next same reaction or activity typically them (e.g. hypoxia (oxygen deficie ncy)). ter throughout the nervous system. A produced by the binding of an Protects the brain from physical or nerve impulse arriving at the axon endogenous substance. chemical injury. Enhances the tonic terminal of one neuron stimulates cortica l/s ubc ort ical control mechanisms release of a neurotr ans mit ter, Natural Nootropics which crosses the microsc opic gap Exhibits few side effects and extremely Bacopa Bacopa also is an effective (see synapse) in millise conds to low toxicity, while lacking the pharma‐ Monnieri antioxi dant and has been used the adjoining neuron's dendrite. cology of typical psychot ropic drugs in a number of anti-aging For example acetylc hol ine, (motor stimula tion, sedation, etc.). formulas. The primary medical dopamine, and serotonin. What's nootropic ?: ingredient derived from the Inha‐ An agent that slows or interferes Bacopa Monnieri plant is the Nootrop ics, also known as smart drugs, bitor with a chemical reaction, a bacopas apo nins alkaloid. are cognitive enhancers. They improve substance that reduces the activity Studies of this drug show that it mental functions cognition, memory, of another substance (as an can improve several different intelli gence, motivat ion, attention, focus, enzyme), a gene that checks the factors related to memory at the concent rat ion, alertness and more. normal effect of another nonallelic same time including memory Read more at nextgen -hu man .com gene when both are present. formation, retention of concepts, MAO- Inhibitor of the enzyme monoamine and restora tion. The effects of Dictionary B oxidase B. MAO-B helps break Bacopa as a Nootropic will be Ada Natural metabolic regulators that inhib down dopamine; inhibiting it best experie nced with long-term p‐ increase the ability of organism to it or prolongs the action of dopamine in consistent usage. tog‐ adapt to environ mental factors and the brain. ens to avoid damage from such factors. Prec‐ A substance, cell, or cellular Nontoxic substance and especially ursor component from which another a plant extract that is held to substance, cell, or cellular increase the body's ability to resist component is formed especially by the damaging effects of stress and natural processes. promote or restore normal physio‐ Cofa‐ A substance that acts with another logical functio ning. ctor substance to bring about certain effects.

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Natural Nootropics (cont) Natural Nootropics (cont) Natural Nootropics (cont)

Huperz Has been used for its nootropic Gingko The ginkgo tree leaves contain The Mushroom (known by the scientific ine-A benefits for hundreds of years, it bilboa terpenoids and flavonoid Lion’s name of Hericium erinaceus) is an is only recently that we discovered glycosides which act as Mane edible mushroom that grows in the mechanism of action of this monoamine oxidase inhibit ors. North America. Lion’s Mane is supplem ent. Huperzi ne-A blocks Ginkgo also improves circula tion popular in traditi onal Chinese the production of acetylc hol ine st‐ throughout the body, protects medicine serving as an antioxi dant erase – a chemical which breaks organs from free radicals and and helping to regulate blood lipid down the neurotr ans mitter Acetyl‐ oxidative damage to the cells and and blood glucose levels. Pills choline when there is too much of may be able to prevent the made from Lion’s Mane are even it. By inhibiting certain receptors formation of blood clots. Ginkgo used to treat gastric ulcers. For

that control the amount of acetyl‐ Biloba has proven effective at those interested in the nootropic chol ine ste rase produced, Huperz‐ enhancing cognition in patients benefits of this mushroom, a 2009 ine-A is therefore able to indirectly diagnosed with dimension and is study from Phytoth erapy Research affect acetylc holine levels. Higher used to boost the memory and found that taking this mushroom amounts of acetylc holine lead to concent rat ion. While it may not resulted in improved cognitive improved cognition and learning be as strong as other nootrop ics, ability. Other studies have shown scores as well as better memory. it is a good addition to any natural that Lion’s Mane increases nerve Acetylc holine also plays a role in nootropic stack. growth factor secreti ons. NGF is a protecting brain cells from dying protein that is vital to the growth as well as being necessary in the and mainten ance of neurons in the formation of new brain cells. brain, contrib uting to long-term brain health.

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Natural Nootropics (cont) Nootropics Types (cont) Nootropics Types (cont)

Yerba Enhance alertness and mental Dop A)Metabolic precursors: L-Phen‐ Choli ne‐ A)P recur sors: Choline, DMAE, Mate acuity without stimula nt- type side a‐ ylal anine, L-Tyros ine, L-DOPA, rgics Meclofe nox ate, Alpha-GPC B)‐ effects, like nervous ness. Yerba min‐ Biopterin, Pyridox al- pho sphate B)‐ Cofactors: Acetylc arn itine, mate, appears to give your brain a erg‐ Reu ptake inhibitors: Aminept ine, Vitamin B5 C)Acetylcholines‐ boost without making you nervous. ics Methylp hen idate, Bupropion C)‐ terase inhibitors: Galanta mine, You feel alert and sharp. Interes ti‐ MAO-B inhibitors: Selegil ine, Ipidacrine (Neirom idin), Lycoris ngly, it actually works as a tonic for Rasagil ine, Rhodiola rosea D)Do‐ radiata (Red Spider Lily), the central nervous system, pamine agonists: Ropinir ole, Huperzine A, Donepezil, calming the body and the mind. It Pramipe xole, Amisulp ride E)Ot‐ Rosemary, Sage, Celastrus has also been shown to improve hers: Mucuna pruriens (Velvet Panicul atus, Cannabis D)R e‐ mood and concent rat ion, reduce Bean), Modafinil: Citicoline uptake inhibit ors and

anxiety, and prevent mental Stim A)A mphet ami nes: Ampheta mine enhancers: Colurac etam, fatigue. A typical cup contains up to ula‐ (Adderall, Dexedri ne), Lisdexa mf‐ Ginseno sides Source, 10 times more of this stimulant than nts etamine (Vyvanse), Methamp he‐ Agonists, Isproni cline, Nicotine, there is caffeine in a cup of coffee. tamine (Desoxyn) B)Adrenergics: Arecoline Source: bestnoo tro pic .org Atomoxe tine, Reboxet ine, GABA Suritoz ole, A5IA Synephrine (found in Bitter orange) blockers

Movie Drugs (fiction) C)C holin erg ics: Arecoline, Nicotine Glut‐ CX-717, IDRA-21, LY-503,430 D)Eugeroics ("Wak efu lness NZT-48, With the help of a mysterious pill amate Enhance rs" ): Adrafinil, Armodaf inil, Limitless that enables the user to access activa‐ Modafinil E)Xanthines: (reduces 100 percent of his brain abilities, tors fatigue percept ion): Caffeine, a struggling writer becomes a cAMP Propent ofy lline, Rolipram, Paraxan thine, Theobro mine, financial wizard, but it also puts Mesembrine Theophy lline him in a new world with lots of Serot on‐ A)P recur sors: 5-HTP, dangers. ergi cs Tryptophan B)Cofactors: Source: imdb.com Pyridoxal C)Reuptake inhibi‐ tors: SSRIs, Sceletium Nootropics Types tortuosum, Hypericum perforatum D)M AO-A inhibitors: Racet ams piracetam, oxirace tam, Resvera trol, Curcumin, phenylp ira cetam, anirace tam, Piperine, Harmal, Rhodiola nefirac etam rosea E)Reuptake enhancers: Vitamins B Vitamins, Omega - 3, Tianeptine and Isoflav ones, Vitamin D supple‐ ments

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Nootropics Types (cont) Nootropics Types (cont) WWW sources (cont)

Anti- st‐ Beta blockers, Lemon Balm, Direct Vasopre ssin, Pregnen olone, https:/ /en .wi kip edi a.o‐ Wikipedia site ress Passion Flower, Rhodiola Rosea, hormones Orexin rg/ wik i/N oot ropic about nootrop ics. St John's Wort, Ginseng Seco‐ DHEA http:// www .no otr op‐ Very big list of (including Siberian ginseng), ndary ics.com /re fs/ ind ex.html smart drugs. Sutherl andia frutesc ens, Kava— enhanc‐ http:// bra inm eta .co m/‐ Forum about an xio lytic herb, Tea, Theanine, ers forum/ cognitive Grape seed extract, Adafen‐ Unknown Bacopa monniera (Brahmi), enhancers. oxate, Phenibut, Picamilon, enhanc‐ Clitoria ternatea (Shankh pu‐ http:// www .lo nge cit y.o‐ Another forum Valerian, Butea frondosa, Gotu ement shpi), Fipexide, Gerovital H3, rg/ for um/ for um/ 169 -b‐ about cognitive Kola, Foti, Panax ginseng, Sulbuti amine, Royal Jelly, rain -he alth/ enhancers. Chinese herbs such as Polygala Curcumin tenuifo lia, Acorus gramineus and Adapt og‐ Holy Basil, Tulsi, Ginseng, About this cheatsheet Huperzia serrata, Bacopa ens Rhodiola rosea, Ashwaganda monnieri, Tulsi (Ocimum This document is a summary of a number of (Withania somnife ra), Reishi sanctum, sweet holy basil) articles from various sources about the "‐ (Ganoderma lucidum) Blood Blessed Thistle, Coenzyme q-10, Smart Drugs". I create a blog on this subject Other mexidol, hydergine, noopept, flow, Creatine, Lipoic acid, Pyritinol, which will have much more informa tion on selank, semax, bifemel ane. metab Picamilon, Ginkgo biloba, nootropic drugs but not only. If you like this Nootropic combina tion of ol ic Vinpoce tine, Vincamine, Nicerg‐ cheatsheet go to my website http: //n ext ge‐ artichoke extract + forskolin or oline n-hu man .com and leave comment : ) other combina tions of 2 or Expe‐ histamine antagonists : The Read more on nextgen -hu man .com more substan ces. rim‐ H3, Ciproxi fan, A-349,821, ABT- ental 239 Racetams Popular Nerve Idebenone, Melatonin, Glutat‐ Piracetam Piracetam is a cognitive Top Noopept, Pramira cetam, growth hione, Acetylc arn itine, Inositol, enhancer and memory popular Modafinil, Adrafinil, Sulbut‐ stimul‐ Anticon vul sants, Phospha tid yl‐ enhancing supplem ent. Many nootro‐ iamine, Phenylp ira cetam, ation, serine, Lion's Mane Mushroom, people across the world use pics Anirace tam, 5-HTP, Huperzine protec‐ SAM-e (S-Aden osyl methion ine), the nootropic, piracetam, to A, Choline (as additional tion Acetylc yst eine (L-cyst eine), effecti vely retain knowledge component) Uncaria tomentosa (Cat's Claw) and improve memory. Most L-thean ine, Caffeine, Ginseng, Piracetam is utilized by both used Gingko younger and older healthy daily individ uals. nootro‐ pics

WWW sources

http:// n It's blog about not only nootropics ex tg‐ but things that can help You en-‐ achieve next level of human hum‐ existence (under constru cti on). an.com

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Racetams (cont) Racetams (cont) Other smart drugs (cont)

Aniracetam An ampakine and a fat-so‐ Oxiracetam Racetam and an ampakine Alpha- Source of Acetyle cho line and a luble nootropic of the racetam that is promoted as a natural GPC fat-sol uble nootropic of the chemical class purported to method of improving Choline chemical class. Alpha- be conside rably more potent cognitive functions through GPC is widely used to help and than Piracetam. Aniracetam the stimula tion of ACh to treat Alzheim er’s, to help in the has the potential of receptors, AMPA receptors recovery of victims of a Stroke, enhancing what is already and NDMA receptors. There improve the memory and overall memorized within ones mind have been clinical studies to mood of people suffering from and allows the mind to reach suggest Oxiracetam can Dementia. Alpha-GPC is used as a state of concent rat ion. improve percept ion, memory, a Nootropic supplement to help Although Aniracetam is more focus, concent rat ion, and improve and increase memory potent than Piracetam, it has alertness. In some studies, and cognition. unique functions which allow Oxiracetam has been shown CDP Source of Acetyle cho line and a more stimula tion of the to increase simple reaction Choline water-s oluble nootropic of the Acetylc holine receptors and times. Choline chemical class. CDP increased focus and energy Source: smartdr ugs for tho ugh t.com Choline is widely used to help within the human brain. and to treat Alzheim er’s and as a Pramir‐ Lipid-s oluble nootropic of the Other smart drugs Nootropic supplement to help acetam Racetam chemical family, improve and increase memory Adrafinil While commonly considered a and has a relatively similar and cognition. CDP Choline has stimulant does not stimulate chemical structure compared been shown to counteract neural motor coordin ation like other to its cousin Anirace tam. degener ation and reduce the stimula nts, and is primarily a However, Pramira cetam is number of apoptotic cells cerebral stimulant. Connected much stronger than Anirac‐ present. CDP Choline also helps with a stimula tion of Hypocre tin, etam. improve visual function in Adrafinil increases how alert and persons suffering from Phenylp ir‐ Shown in a clinical study to awake one feels. A higher level Glaucoma, and Amblyopia. CDP acetam have a wider and more of Hypocretin causes an Choline is known to help effective range of benefits in increase in dopamine, norepi‐ increase the glucose metabolism comparison with Piracetam. neph rine, and histami nes. All in the brain as well as cerebral Phenylp ira cetam was shown three of these play a role in blood flow. to improve memory functions, overall energy levels, making problem solving skills, and Adrafinil a choice nootropic to attention switching. Another take before a intense workout or study showed Phenylp ir‐ long study session. acetam had a wide range of benefits including increased locomotion skills, antidep re‐ ssant benefits, and memory enhance ment.

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Other smart drugs (cont) Other smart drugs (cont) Other smart drugs (cont)

Centro‐ Choline rgic compound that Sulbut Fat-sol uble nootropic, that passes Noopept Recent nootropic that was first phe‐ contains DMAE, and is lipid iamine the Blood Brain Barrier more patented in Russia in 1995. noxine soluble. Centrop hen oxine readily than Thiamine. Sulbut‐ Noopept has been shown to increases the uptake of oxygen iamine is known to be choline rgic, have neuro-p rot ective qualities and glucose uptake in the glutama tergic and dopamin ergic. through the stimula tion of a brain. Through the increase of The potenti ation of glutama tergic protein known as Nerve Growth glucose uptake, Centrop he‐ activity in the Prefrontal Cortex is Hormones (NGH) which plays noxine helps in rectifying the believed to be one of the an active role in reducing and damage done to the brain from Mechanisms of Action that grants even preventing neuronal aging. The brain uses 20 Sulbuti amine the ability to degener ation in the hippoc‐ percent of the body’s oxygen, if increase memory functio nal ity. ampus. The effective dose the oxygen levels become Sulbuti amine is shown to cause an range of Noopept in comparison deficient the brain loses effici‐ increase in choline rgic activities in to Piracetam was 1000 times ency. By increasing the flow of the Hippoca mpus, this area of the lower and also that spectrum of

oxygen to the brain Centrop he‐ brain plays a pivotal role in the mneumot ropic activity was noxine helps increase the consoli dation of both short and greater in regards to Noopept. product ive ness of the brain all long term memory as well as This showed that the dipeptide around. spatial navigation and memory. Noopept was much stronger L- Not just improve scores on tests Another plausible cause of Sulbut‐ than Piracetam. iamine improving cognition and Theanine of learning and memory, it also Source: smartdÂ r u gÂs fo Âr thÂ o u gÂh t.com affects many other variables. L- memory is through the suppre‐ Theanine has been shown to ssion and reduction of dopamine lower blood pressure, and released in the Prefrontal Cortex. anxiety. It has also been shown These various Mechanisms of to aid in the improvment of the Action make Sulbuti amine an body’s immune system by underst and able choice in increasing the amount of improving cognitive and memory affliction fighting gamma delta abilities. T-Cells, and increasing antiba‐ cterial proteins.