Directeur de la rédaction Pr François Paille Rédacteur en chef Pr Amine Benyamina Rédacteurs associés Dr Philippe Batel Dr Ivan Berlin Dr Laurent Karila Pr Michel Lejoyeux Pr Mickaël Naassila Rédactrice Sciences humaines Pr Myriam Tsikounas Rédactrice Sciences psychologiques Pr Isabelle Varescon-Pousson Comité de rédaction Pr Georges Brousse Pr Olivier Cottencin Dr Michel Craplet Pr Jean-Bernard Daeppen Dr Jean-Michel Delile Pr Maurice Dematteis Dr Claudine Gillet th Dr Geneviève Lafaye 17 European Society for Biomedical Research Pr Michel Reynaud Dr Alain Rigaud Dr Marc Valleur on Alcoholism Congress Directeur de la publication Pr Mickael Naassila 21-24 September 2019, Lille Comité scientifique Pr Jean Adès Pr Thomas F. Babor Pr Jean-Louis Balmès Pr Maurice Bazot Dr Mats Berglund Pr Jacques Besson Pr Jean-Pierre Blayac Pr Jonathan D. Chick Mme Marie Choquet Pr Philippe de Witte Pr Michel Escande Pr Claude Got Dr Antoni Gual Pr Momar Gueye Pr Roger Henrion Pr Denise Kandel Pr Michel Le Moal Pr Karl Mann Mme Véronique Nahoum-Grappe Dr José Maria Neves Cardoso Pr Philippe-Jean Parquet Pr Jean-Louis Pedinielli Pr Falvio Poldrugo Pr Bernard Roques Pr John A. Talbott Pr Jean-Luc Vénisse Pr Lars von Knorring Pr Jacques Weill Pr Jean-Jacques Yvorel
ISSN 2554-4853 Trimestriel Société Française
PRINCEPS Éditions SEPTEMBRE-DÉCEMBRE 2019 - Tome 41, n° 3-4 d’Alcoologie
!BSTRACTS CONGRÈS
Pr Mickael Naassila* * President 17th ESBRA Meeting
17th European Society for Biomedical Research on Alcoholism congress 21-24 September 2019, Lille – Invited talks and Symposia abstracts
Invited talks forward, such as combining training with neurostimulation. Together these fndings emphasize the malleability of the addicted brain and the promise of targeted CT in the treat- Targeting biased decision making in the treatment ment of AUD. of alcohol use disorders Reinout Wiers (Amsterdam, The Netherlands) ASH-NASH synergism and its underlying mechanisms Alcohol Use Disorder (AUD) and other addictions have been Hidekazu Tsukamoto (Los Angeles, USA) characterized as a chronic brain disease from the biomedical perspective and as the unfortunate outcome of adverse social Alcohol misuse and obesity are two leading independent risk conditions from the social science perspective. We emphasize factors for alcoholic and non-alcoholic steatohepatitis (ASH biased decision making as a central characteristic in (alcohol) and NASH) around the globe. Synergistic interactions by addiction. From a therapeutic perspective, the important these factors have also increasingly been recognized. In fact, question is to what extent these biases reverse after successful the emerging evidence indicates the average BMI of some abstinence, and to what extent they can be reversed through ASH patient populations in the US may be around 30. ASH targeted training. Two types of Cognitive Training (CT) and alcoholic cirrhosis occur as the consequences of alco- can be distinguished: those in which general abilities are hol addiction which dictates heavy drinking and sustained trained (e.g., working memory training) and those in which blood alcohol levels (BAL) due to physical dependence. Tis initial motivational reactions to alcohol are targeted, so called condition can be reproduced in rodents by intragastric fee- cognitive biases (Cognitive Bias Modifcation, CBM, Wiers ding of ethanol diet which also allows precise reproduction 2018). I will review the state of afairs in both. Training of of the synergism between sustained BAL and overfeeding- general abilities takes a long time, but does show promise for induced obesity. Tis model exhibits heightened steatohepa- a subgroup of patients. CBM has shown to increase one-year titis, M1 macrophage activation, nitrosative stress driven by abstinence in several large clinical trials, with efect sizes Notch-dependent mitochondrial metabolic reprogramming. similar to medication for alcohol (NNT=12). It is also beco- Moderate alcohol intake may also synergistically work with ming clear for which individuals CBM shows most promise NASH to promote liver cancer development. Evidence sug- as an add-on treatment (those with a strong cue-reactivity gests social drinking is sufcient enough to promote live can- and/or impulsivity), and we are beginning to understand cer incidence in NASH-cirrhosis patients. Tis synergism is the neurocognitive mechanisms underlying training efects reproduced in mice injected with the hepatocarcinogen DEN (e.g., reduced cue-reactivity). CT shows modest but reliable and fed alcohol-containing Western diet. Tumor promotion efects as add-on to regular psychosocial treatment, but does in this model is dependent on activation of hepatic stellate not appear to work in the absence of psychosocial treatment, cells (HSC) driven by Wnt- -catenin-mediated overexpres- nor in the absence of motivation to change (e.g. in proof- sion of stearoyl-CoA-desaturase (SCD), which in turn esta- of-principle studies in students). Finally, I will sketch ways blishes a SCD-LRP5/6-Wnt positive loop to amplify Wnt-
Alcoologie et Addictologie. 2019 ; 41 (3) : 232-282 232 Congress