2016 and Over 4,000 Research Scientists, 168 Scientific Leaders and 60,000 Was Our Leader and Guiding Light, Providing Inspiration and Moti- Pression

INVEST IN MENTAL HEALTH

a n n u a l r e p o r t 2 0 1 6 Dear Brain & Behavior Research Foundation Supporters:

From mental illness to mental health–30 years of achievements by tremendous impact on psychiatric research and treatment. Connie problems improves symptoms of some patients with refractory de- The Foundation is proud of our accomplishments in 2016 and over 4,000 research scientists, 168 scientific leaders and 60,000 was our leader and guiding light, providing inspiration and moti- pression. In a study of patients with treatment-resistant depression, we are excited to focus on the promising path of discovery. With donors. We are proud to present you with our 2016 annual report vation to all who ever had the honor and privilege of knowing and about two thirds had metabolic deficiencies that affect the brain’s your sustained commitment, we will accelerate the funding of our and invite you to invest in mental health. working with her. She will be dearly missed by us all. But her legacy ability to produce neurotransmitters. Dr. Pan’s research found Grants and continue to lead the field with breakthroughs that continues with each new scientist which we support and each new that patients’ depression symptoms declined significantly when improve the lives of those living with mental illness. Thank you for Since 1987, the Brain & Behavior Research Foundation has invest- discovery which improves people’s lives. their metabolic problems were treated. Some of the patients even continuing the journey with us. ed in the future. We support the innovative brain and behavior reached remission. The most common of the deficiencies observed research today which will lead to new treatments and eventual While we are proud of our accomplishments, there is still much in the participants was in levels of cerebral folate, which is treat- Sincerely, cures in the future. more to be done. More than ever, private funding of brain and able with folinic acid. behavior research is vital to jumpstart pilot research projects that 2016 was a highly productive year for the Foundation and the criti- will advance our understanding of mental illness. While the federal THE INVESTMENT CONTINUES—LOOKING FORWARD cal role we play as the venture capitalists of neuroscience. government is the largest funder of scientific research, its budget is still less than needed. The recent federal budget administrative In 2016 the Scientific Council reviewed 761 project proposals • In 2016, we funded more than $19 million in grants proposal calls for an 18% cut in spending for biomedical research. for Young Investigator Grants and noted the exceptional quality divided between 15 Distinguished Investigator Grantees, It undermines key research programs, particularly in mental health. of a large majority of the applicants’ proposals. Ultimately 198 80 Independent Investigator Grantees, and 400 Young projects were funded at $70,000 each for a two year period. The Investigator Grantees. Any reduction in federal funding would be devastating to the work Independent Investigator Grants were awarded to 40 exceptional • We continued to ensure that every dollar donated for re- and careers of brain and behavior researchers nationwide, but this researchers with a variety of new approaches to understand and search is invested in our grants to scientists thanks to the is especially true for young scientists who wish to pursue careers in treat mental illness and were selected from 326 applicants. Inde- generous support of two family foundations which cover our brain research. Scarce resources mean even more competition for pendent Investigators are funded with $100,000 over two years. JEFFREY BORENSTEIN, M.D. operating expenses. federal grants and greater difficulty in pursuing scientific careers. For our 2016 Distinguished Investigator Grants, 151 applications President and CEO • This year marks the achievement of awarding more than $360 Because of these decreases in government funding, we are at great were received and 15 outstanding one-year research projects million, (since our inception), to fund more than 4,000 leading risk of losing an entire generation of scientists. were selected for funding at $100,000 each. scientists around the world which has led to more than $3.5 billion in additional funding for these scientists. To keep neuroscience flourishing and momentum in the field, This year also saw the publication of a research paper by a 2009 sustained and accelerated support are required to continue and 2014 Young Investigator Carolyn I. Rodriguez, M.D., Ph.D., of This annual report highlights remarkable research that has been to advance. Stanford University School of Medicine. Results of the small proof- funded through Foundation Grants this past year. Some of the of-concept study reported December 1, 2016 in The American major discoveries made by our Grantees in 2016 are discoveries THIRTY YEARS OF GRANTS: BREAKTHROUGHS AND MOMENTUM Journal of Psychiatry, found that rapastinel, an experimental drug in basic research, new technologies, next-generation treatments, currently being evaluated for the treatment for major depression, early intervention and diagnostic tools, which ranged from new Starting with ten grants in 1987, by year’s end 2016 we had may relieve the symptoms of obsessive compulsive disorder (OCD) STEPHEN A. LIEBER experiments that reveal the brain circuitry behind the inability awarded $360 million in more than 4,000 grants in the U.S. and 34 rapidly and with few side effects. Dr. Rodriguez and her colleagues Chair, Board of Directors to experience pleasure, a milestone in the search for the cause other countries. In thirty years of funding research, we have helped are investigating rapastinel because they previously found that of schizophrenia, and findings that explain how ketamine exerts psychiatry and neuroscience advance significantly and have estab- some OCD patients receive rapid relief from their symptoms when its rapid antidepressant effects. The 2016 Top 10 advancements lished great momentum in the field. treated with ketamine. Hoping to find a treatment that reduces were selected because of their significant contributions to our patients’ obsessions and compulsions quickly without dissociative understanding of brain and behavior disorders as well as poten- Innovation and advances, involve taking a chance on a vision for side effects, Dr. Rodriguez turned to rapastinel because it, like tial new treatments. the future. All Foundation Grant projects are selected by our ketamine, is a drug that modulates the action of NMDA receptors all-volunteer Scientific Council, comprised of leading neuroscien- in the brain – docking ports for the neurotransmitter glutamate We are proud that our Grants support a broad range of the best tists across disciplines in brain and behavior research, including and important in learning, memory and synaptic plasticity and ideas in brain research and that our grantees have taken substan- two Nobel Laureates and four former and the current director of thought to play a role in OCD. But rapastinel works differently than tial steps forward on the path to developing new treatments and the National Institute of Mental Health. These distinguished lead- ketamine and has a lower risk of causing dissociative side effects, HERBERT PARDES, M.D. finding cures for mental illness. ers are uniquely qualified to identify new research projects that the researchers say. President, Scientific Council may be unproven but offer potential for significant breakthroughs. Unfortunately, this year we also lost our beloved President Emeri- They select the most promising ideas in which to invest, whether As 2016 came to a close we began to celebrate our 30th anniver- tus, Constance E. Lieber, a global champion of psychiatric research. proposed by budding early career neuroscientists or by estab- sary. Of course, the longevity and impact the Foundation has had, Connie passionately believed in the need to seed the field of neuro- lished scientists seeking to explore new paths. and continues to have, is only possible because of each and every psychiatric research with as many talented scientists as possible to one of you who support our mission and understand that invest- make a substantive impact on the broad spectrum of mental health One such grantee selected by our Scientific Council, whose re- ing in mental health neuroscience research will bring us closer to research, which she fervently understood holds our best hope for search in next generation treatment for depression made our list of the day when better treatments and even cures are possible. ending the immense suffering caused by mental illness. Connie 2016 Top 10 Advancements and Breakthroughs, was Dr. Lisa Pan. was a deeply caring and visionary philanthropist, who has had a Dr. Pan and her colleagues have discovered that treating metabolic

2 ANNUAL REPORT 2016 www.bbrfoundation.org 3 Table of Contents

06 Our Global Footprint 12 Top Ten Advancements & Breakthroughs 23 Webinars 24 Scientific Council 26 Our Newest Scientific Council Members 32 2016 Investments in Research Grants BOARD OF DIRECTORS Marc R. Rappaport OFFICERS Virginia M. Silver 37 Grants by Illness Kenneth H. Sonnenfeld, Ph.D., J.D. CHAIRMAN Barbara K. Streicker 60 Foundation Events Stephen A. Lieber Barbara Toll 66 Parenting Robert Weisman, Esq. VICE PRESIDENT 70 A Tribute to Contstance Lieber Anne E. Abramson EX-OFFICIO PRESIDENT & CEO 72 Donors SECRETARY Jeffrey Borenstein, M.D. Research Partners John B. Hollister PRESIDENT, SCIENTIFIC COUNCIL Donor Listings TREASURER Herbert Pardes, M.D. Arthur Radin, CPA Honor Tributes PUBLICATION CREDITS Memorial Tributes DIRECTORS Carol A. Atkinson WRITERS 95 Community Partners Eric Bam Peter Tarr, Ph.D. Donald M. Boardman Becky Ham 96 Team Up for Research J. Anthony Boeckh 99 Donor Stories Susan Lasker Brody EDITOR Paul T. Burke Lauren Duran 102 Foundation Prizewinners Suzanne Golden Bonnie D. Hammerschlag DESIGN 104 2016 Financial Summary John Kennedy Harrison II Jenny Reed Carole H. Mallement © 2017 The Brain & Behavior Milton Maltz Research Foundation

4 ANNUAL REPORT 2016 www.bbrfoundation.org 5 OUR GLOBAL FOOTPRINT

TOTAL AMOUNT AWARDED SINCE 1987

MORE THAN $360M 16 329 8 England 131 2 Scotland 13 1 Ireland 14 36 1 42 Wales 13 3 36 1 TOTAL NUMBER OF COUNTRIES 4,358 5 24 26 26 1 10 8 4 1 82 1 2

3 1 1 2 TOTAL GRANTS AWARDED 1 5,200+ n tota 6 4,300+ n t U.. 900+ Outid t U.. 67 4,086 Young Investigator Grants 2 788 Independent Investigator Grants 409 Distinguished Investigator Grants 4

2016 GRANT STATISTICS

2016 GRANTS YOUNG INDEPENDENT DISTINGUISHED U.S. $14,280,000 FOREIGN $4,820,000 TOTAL $19,100,000 INVESTIGATORS INVESTIGATORS INVESTIGATORS 6 Aiation 12 Aiation 26 Aiation GLOBAL INSTITUTIONS 1 Awardd 1 Awardd 0 Awardd 1 Nw rant Nw rant 20 Nw rant U.S. 332 FOREIGN 215 TOTAL 547 1 Prior rant 11 Prior rant 20 Prior rant

6 ANNUAL REPORT 2016 www.bbrfoundation.org 7 GRANTS BY STATE SINCE 1987

New York: 757 California: 642 Massachusetts: 452 Maryland: 306 Connecticut: 302 Pennsylvania: 268 Texas: 177 North Carolina: 153 Illinois: 113 Georgia: 93 Michigan: 89 Tennessee: 87 Ohio: 82 Missouri: 58 Colorado: 49 Iowa: 49 Washington: 48 Wisconsin: 44 Virginia: 38 New Jersey: 35 Rhode Island: 34 Minnesota: 33 Indiana: 31 Oregon: 25 Florida: 25 South Carolina: 19 Washington D.C.: 18 Alabama: 16 New Hampshire: 16 New Mexico: 16 Louisiana: 15 Kentucky: 13 Utah: 13 Arizona: 10 Mississippi: 10 Oklahoma: 7 Arkansas: 7 Nebraska: 6 Vermont: 5 Kansas: 4 Hawaii: 4 West Virginia: 4 Maine: 1 Delaware: 1

NUMBER OF GRANTS BY STATE FROM 19872016

WA 50 ME MT ND 2

OR VT 26 MN 6 NH 34 16 MA ID N 472 SD WI 787 49 W MI RI 88 CT 34 317 IA PA NE 49 279 N 37 NV 6 OH 85 UT I IN DE 118 33 2 CA 18 CO WV 677 51 3 VA MD KS MO K 40 310 4 61 13 D.C. NC 20 TN 160 A OK 92 13 NM 7 AR SC 17 6 20 MS A GA 10 16 94 T A 187 17

F U.S. Virgin Islands 1 27

AK HI TOTAL NUMBER OF STATES 4 WITH GRANTS IN THE U.S. NUMBER OF GRANTS BY STATE 43 4,358 PLUS THE DISTRICT OF COLUMBIA AND THE U.S. VIRGIN ISLANDS

8 AnnualANNUAL Report REPORT 2016 2016 www.bbrfoundation.orgwww.bbrfoundation.org 9 TOTAL AMOUNT AWARDED SINCE 1987

TOTAL AMOUNT OF US DOLLARS AWARDED IN MILLIONS

400000000 $361M

$342M

350000000 $324M

$306M

$288M 300000000 $273M $275M

$255M

$237M

250000000 $219M

$199M 200000000 $180M $162M

$144M 150000000 $128M $112M $100M 100000000 $83M $68M $55M $43M $34M 50000000 $25M $20M $15M $8M $11M $.25M $1M $3M 0 1987 1988 1989 1990 1991 1992 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 2005 2006 2007 2008 2009 2010 2011 2012 2013 2014 2015 2016

10 ANNUAL REPORT 2016 www.bbrfoundation.org 11 t o p 10

New Experiments Reveal Brain Circuitry advancements & 1 Behind Inability to Experience Pleasure A Milestone in the Search for 2 Schizophrenia’s Causes Genetic Anomalies Frequently Associated with Neurodevelopmental Disorders Can breakthroughs 3 Now Be Efficiently Recreated in the Lab Opioid Medication Combo Helps Patients by Foundation Grantees in 2016 4 Who Don’t Respond to Antidepressants Important Discovery by Foundation-Supported Researchers Explains How Ketamine Exerts its 5 Rapid Antidepressant Effects

Treatment with Immune-Regulating Gut Bacteria May Boost Immune System 6 Against Stress

Brief Course of Psychotherapy Benefits Moms with Major Depression and Their 7 Children

New Tool Calculates Patients’ Personal 8 Psychosis Risk Treating Metabolic Problems Improves Symptoms of Some Patients with Refractory 9 Depression “The top 10 discoveries were selected because of their significant contributions to our understanding of brain and behavior disorders Researchers Catalog Subtle but Widespread as well as potential new treatments. We are proud to be able to say 10 Schizophrenia-Associated Differences in that NARSAD Grants support a broad range of the best ideas in Gene Activity brain research and that our grantees have taken substantial steps forward on the path to developing new treatments and finding Listed in Order of Publication cures for mental illness.”

—Jeffrey Borenstein, M.D.

12 ANNUAL REPORT 2016 www.bbrfoundation.org 13 TOP 10 ADVANCEMENTS & BREAKTHROUGHS

1 2 3 Journal: Nature—January 27, 2016 Journal: Science—January 1, 2016 Journal: Nature Neuroscience—February 1, 2016 PATRICK F. SULLIVAN, M.D., FRANZCP CONOR LISTON, M.D., PH.D. University of North Carolina at Chapel Hill JAMES F. GUSELLA, PH.D. Weill Cornell Medical College Harvard University/Massachusetts General Hospital 2014 Lieber Prizewinner 2016 Freedman Prize Honorable Mention 2007 NARSAD Distinguished Investigator Grant 2010 NARSAD Distinguished Investigator Grant 2013 NARSAD Young Investigator Grant

KARL DEISSEROTH, M.D., PH.D. MICHAEL O’DONOVAN, M.D., PH.D. MICHAEL E. TALKOWSKI, PH.D. Stanford University School of Medicine Cardiff University Harvard University/Massachusetts General Hospital Scientific Council Member 2012 Lieber Prizewinner 2012 NARSAD Young Investigator Grant 2013 Goldman–Rakic Prizewinner 2005 NARSAD Young Investigator Grant

Basic Research: Depression, Schizophrenia Basic Research: Schizophrenia New Technology: Autism, Schizophrenia, Intellectual Disability dozens of genes have been deleted or duplicated, lead to abnormal NEW EXPERIMENTS REVEAL BRAIN CIRCUITRY BEHIND INABILITY A MILESTONE IN THE SEARCH FOR SCHIZOPHRENIA’S CAUSES GENETIC ANOMALIES FREQUENTLY ASSOCIATED WITH levels of gene activity. The alterations are thought to be one of most TO EXPERIENCE PLEASURE Research, reported in Nature and featured in the New York NEURODEVELOPMENTAL DISORDERS CAN NOW BE EFFICIENTLY common causes of neurodevelopmental and psychiatric disorders, Anhedonia, or the inability to feel pleasure or enjoyment, is a key Times, by a large international team that included Drs. Sullivan RECREATED IN THE LAB but teasing out their precise effects has been difficult. SCORE offers symptom in several mental illnesses including major depression and O’Donovan, who are leaders of the Psychiatric Genomics A new method for recreating large-scale genetic anomalies known researchers an efficient way to modify the DNA in lab-grown cells to and schizophrenia. This sense of pleasure is generated in part by Consortium, points to one of the likely causes of schizophrenia as copy number variations will make it easier for scientists to study introduce duplications or deletions that precisely match those that the brain’s neural pathways involved in seeking and experiencing in some people: overactive pruning of synapses–connections the effects of those mutations, many of which have been linked occur in individuals with a particular disorder. reward. In a new study by led by Karl Deisseroth, M.D., Ph.D., of between nerve cells–in the brain’s prefrontal cortex during the to autism and other neurodevelopmental disorders. Scientists Stanford University, researchers have now identified in rodents early years of life. The team focused on variation in genes giving have already used the approach to create human cells that carry The research team demonstrated their technique by replicating two some of the neural circuitry that appears to regulate reward be- rise to a vital group of proteins called the major histocompatibility too many or two few copies of chromosomal regions known as specific copy number variations implicated in psychiatric disorders, havior across different sections of the brain. complex (MHC). MHC proteins are part of the mechanism used by 15q13.3 and 16p11.2 – copy number variations associated with a but the approach can be readily applied to produce other muta- the immune system to fight off foreign invaders. The team found range of disorders including autism, schizophrenia, and intellectu- tions of the same type. That means researchers can explore the By controlling the activity of dopamine neurons in a part of the that variations in the expression of genes known as complement al disability. The achievement paves the way for studying exactly effects of any copy number variation by engineering cells that carry brain called the medial prefrontal cortex, Deisseroth, a Scientific component 4 (C4) genes specifically impacted neuronal synapses, what goes wrong in cells that carry the defect, and could help the mutation and comparing them to cells that lack the mutation, Council member and 2005 and 2007 Young Investigator, and his dendrites, axons, and cell bodies. In mice, C4 mediated synapse researchers find ways to correct those problems. but are otherwise genetically identical—a strategy scientists hope colleagues reported in the January 1 issue of Science that they can elimination during postnatal development. Excessive C4 activity will help illuminate what goes wrong in a wide range of disorders. produce symptoms of anhedonia in rodents. Hyperactivity in the may help explain the reduced numbers of synapses in the brains The new method is an important new application of CRISPR, a medial prefrontal cortex in humans has been associated with an- of individuals with schizophrenia. research tool that is changing the way scientists “edit” genomes in hedonia in patients with depression. In rats, stimulating activity in the lab. Based on the cutting action of an enzyme found in bacte- that part of the brain caused the animals to avoid their preferred ria, CRISPR enables researchers to cut and paste DNA in a manner sugar water and shy away from socializing with their cage-mates. not unlike that of adding and deleting letters in a word processor. It is much easier and more precise than prior genome modifica- The scientists used a combination of functional magnetic reso- tion methods. nance imaging and optogenetics (a technique that uses pulses of light to control specific brain cells) to observe how the activity in James F. Gusella, Ph.D. and Michael E. Talkowski, Ph.D., both of the reward circuitry in the medial prefrontal cortex can suppress Harvard University and Massachusetts General Hospital, led the activity in other parts of the brain, such as the striatum, that are in- development of the new CRISPR-based technique, which they volved in reward-seeking behavior. Together, these findings provide call SCORE. Their study was reported February 1 in the journal a much clearer picture of how reward-seeking pathways operate Nature Neuroscience. in the brain, and may help scientsits learn more about how these pathways relate to anhedonia. Copy number variations, in which segments of DNA that can span

14 ANNUAL REPORT 2016 www.bbrfoundation.org 15 TOP 10 ADVANCEMENTS & BREAKTHROUGHS

4 5 Journal: American Journal of Psychiatry—February 12, 2016 Journal: Nature—May 4, 2016 Carlos A. Zarate, M.D. National Institute of Mental Health Maurizio Fava, M.D. Todd Denton Gould, M.D. (NIMH/NIH) Harvard University/ Massachusetts General Hospital National Institute of Mental Health (NIMH/NIH) 2011 Foundation Bipolar & Mood 1994 NARSAD Young Investigator Grant 2013 Independent Investigator Grant Disorder Research Prizewinner 2005 Independent Investigator Grant *Team included: 2002 Independent Investigator and 2010 & 2004 Young Investigator Grant 1992 Young Investigator Madhukar H. Trivedi M.D. 1996 Young Investigator Grant

Next-Generation Treatments: Depression 1950s by the first generation of modern phan showed greater improvements than Next-Generation Treatments: The new research suggests it may be does not primarily rely on altering brain OPIOID MEDICATION COMBO HELPS antidepressants. Although recent research the patients in the placebo group. Overall, Suicide, Depression possible to separate ketamine’s benefits levels of the neurotransmitters serotonin PATIENTS WHO DON’T RESPOND TO has reopened the investigation on opioids, the drug combination was well tolerated IMPORTANT DISCOVERY BY FOUNDATION- from its unwanted effects. Inside the body, or norepinephrine. It does, however, block ANTIDEPRESSANTS showing the brain’s opioid system is in- and the participants didn’t show symptoms SUPPORTED RESEARCHERS EXPLAINS ketamine is broken down, forming several signaling from a nerve cell receptor called Reviving an old treatment for mood prob- volved in mood disorders, the use of opioid of opioid withdrawal after finishing the HOW KETAMINE EXERTS ITS RAPID new compounds, called metabolites. The the NMDA receptor—this is how it acts as lems, researchers find that adding certain medications is limited because they are treatment course, the researchers found. ANTIDEPRESSANT EFFECTS team discovered that one of these metab- an anesthetic, and also why it causes its opioid medications to depression treat- addictive and may be abused. Foundation-supported scientists have just olites—a molecule called hydroxynorket- most significant side effects. Researchers ment can help patients who don’t respond The findings suggest that the buprenor- solved an important mystery. They have amine (HNK)—is responsible for ketamine’s had thought ketamine’s antidepressant well to conventional antidepressants. In a In the new study, researchers developed phine/samidorphan combination is a determined how ketamine, a drug ap- antidepressant effects. In mice, HNK effects might also be due to inhibition of new study published February 12, 2016 in an opioid drug combination made of promising candidate for treatment of proved long ago as an anesthetic but used reduces depression-associated behaviors the NMDA receptor, but the team’s studies the American Journal of Psychiatry, patients buprenorphine, an opioid medication, and major depressive disorder in patients who recently on an experimental basis in treat- as well as ketamine, but does not cause of HNK showed this is not the case. who received a combination of opioid samidorphan, which was included to block have an inadequate response to standard ing major depression, exerts its beneficial ketamine’s side effects. medication and antidepressants saw great- those effects of buprenorphine that are antidepressants, the scientists say, adding antidepressant effect. Dr. Gould and his colleagues found that er improvements than their peers who associated with its addictive potential. The that future research with larger groups of The findings were reported May 4 in the HNK reduces depression-like behaviors in received only antidepressants. research team led by Maurizio Fava, M.D., patients is needed to confirm the results. Low doses of the drug rapidly alleviate journal Nature. Further studies will be mice without inhibiting NMDA receptors, at Massachusetts General Hospital and symptoms of depression, including major needed to determine whether HNK has the instead activating molecules called About 60 to 70 percent of patients do Harvard Medical School, and also included depression that has resisted other forms same effect in patients. But the research- AMPA receptors. The finding could help not respond to their initial treatment Madhukar H. Trivedi M.D. at UT Southwest- of treatment. Studies have found patients ers, led by Todd Denton Gould, M.D. at the researchers design a new generation of with antidepressants. After switching to ern Medical Center. with depression experience dramatic im- University of Maryland School of Medicine antidepressants. a different type of antidepressant, still provement within hours of treatment with and Carlos A. Zarate, M.D. at the National about 40 percent of patients do not see More than 140 people with major ketamine, whereas traditional antidepres- Institute of Mental Health, say their dis- any or enough improvement in their depression who had not responded well sants can take weeks to take effect. But se- covery has already provided a new under- depression symptoms. to one or two courses of antidepressant rious side effects, including hallucinations standing of how ketamine acts on the brain treatment participated in the study. and the feeling of being outside one’s own to exert its antidepressant effects. In trying to develop new treatments for Participants were randomly assigned to body (dissociation), as well as a potential patients with difficult-to-treat depression, either a group that had buprenorphine/ for abuse, have limited ketamine’s potential Unlike commonly used “SSRI”-class antide- some researchers have turned to drugs samidorphan added to the antidepressant for clinical use in treating depression. pressants (such as Paxil, Lexapro, Celexa, that act on different systems of the brain. treatment or a group that received only Prozac), ketamine’s mechanism of action antidepressant and placebo. One such class of drugs is opioids, which affect the brain’s opioid system and have After four weeks of treatment, those par- been used to treat mood problems for ticipants who had received the additional centuries, before being displaced in the treatment with buprenorphine/samidor-

16 ANNUAL REPORT 2016 www.bbrfoundation.org 17 TOP 10 ADVANCEMENTS & BREAKTHROUGHS

6 7

Journal: Proceedings of the National Academy of Sciences—May 31, 2016 Journal: Journal of the American Academy of Child & Adolescent Psychiatry—June 2016

Christopher A. Lowry, Ph.D. Holly A. Swartz, M.D. University of Colorado, Boulder University of Pittsburgh 2010 & 2007 NARSAD Young Investigator Grant 2006 NARSAD Young Investigator Grant *Team included: 2005 Independent Investigator Monika Fleshner, Ph.D. and 2013 NARSAD *Team included: 2006 Ruane Prizewinner and 2001 Distinguished Investigator David A. Brent, Independent Investigator Charles L. Raison, M.D. M.D.; 1998 Distinguished Investigator Ellen Frank, Ph.D.; and 2002 Independent Investigator John C. Markowitz, M.D., Pharm.D.

Next-Generation Treatments: Multiple Illnesses Next-Generation Treatments: Depression mood or anxiety disorders. Mothers par- TREATMENT WITH IMMUNE-REGULATING GUT BACTERIA MAY The researchers injected mice with a bacterium called Mycobac- BRIEF COURSE OF PSYCHOTHERAPY ticipated in nine 45-minute psychotherapy BOOST IMMUNE SYSTEM AGAINST STRESS terium vaccae, which is abundant in soil and has immune sys- BENEFITS MOMS WITH MAJOR DEPRESSION sessions over three months. For one group Exposing mice to bacteria that help regulate the immune system tem-regulating effects. (Immunoregulation is the control of specific AND THEIR CHILDREN of women, this therapy was focused on the can help to prevent stress from causing harmful inflammation, and immune responses and interactions between immune cells, When mothers who suffer from major mother’s relationship with her child. A sec- in some cases, illness, reports a scientific team in the May 31, 2016 particularly those resulting in a balanced production of different depression undergo a brief period of psy- ond group of women underwent a more issue of Proceedings of the National Academy of Sciences. classes of T cells that promote and suppress inflammation.) The chotherapy, they and their children both general form of therapy. bacteria were prepared in a way that made it impossible for them benefit, according to research reported The findings support the idea that “reintroducing” humans to proliferate in the body and thereby infect the animals, but could this month in the Journal of the American The symptoms of depression declined to certain bacteria may promote health and wellness, the still, nevertheless, affect the immune system. Academy of Child & Adolescent Psychiatry. quickly for all of the women in the study, researchers said. Children whose mothers have depression and three to six months after the moth- This prevented mice from getting colitis when put in highly stress- are more likely than others to develop ers improved, their children’s symptoms Previous research shows that inflammatory diseases such as ful situations. In stressed mice, the treatment had anti-anxiety childhood psychiatric illnesses. Research- improved as well. This was true regardless inflammatory bowel disease and colitis are becoming increasingly and fear-reducing effects, the researchers found. In mice that had ers have found that these children do of which form of therapy the mothers more common in modern societies. According to “the hygiene inflammatory bowel disease, the bacterial treatment prevented better when mothers are treated for their received. hypothesis,” increased levels of cleanliness in our urban lives have stress-induced aggravation of colitis. depression and their symptoms improve— made us lose touch with the good microbes in the environment, but until now such studies had involved Children whose mothers underwent the “the old friends” we’ve evolved with, and as a result, we are Together, these findings can help researchers develop microbi- women whose depression was treated with relationship-focused therapy, however, less able to rely on our immune system to protect us against ome- and immunoregulation-based strategies to prevent disor- medication, not psychotherapy. had fewer mental health visits and were inflammatory diseases. ders related to stress, the researchers said. prescribed fewer antidepressant medica- The new study, led by Holly A. Swartz, M.D. tions during the study than children whose Risk for psychiatric disorders ranging from depression to PTSD to and Ellen Frank, Ph.D., both at the Univer- mothers underwent the general therapy. schizophrenia is thought by some scientists to be linked to elevat- sity of Pittsburgh, investigated the impact The relationship-focused therapy may ed levels of inflammation. of a brief period of psychotherapy on both equip mothers to help their children im- mothers and children. prove with fewer medications and psychi- In the new study, researchers investigated how stress acts on the atric services, the researchers say. normal relationship between the body and the microbial commu- The study included 168 women with major nity occupying the body, which is collectively called the microbiota. depressive disorder and their children, They showed that stress disrupts this relationship, resulting in who were between the ages of 7 and 18 elevated inflammation. and had themselves been diagnosed with

18 ANNUAL REPORT 2016 www.bbrfoundation.org 19 TOP 10 ADVANCEMENTS & BREAKTHROUGHS

8 9

Journal: American Journal of Psychiatry— Ricardo E. Carrión, Ph.D. Journal: American Journal of Psychiatry—August 13, 2016 July 1, 2016 [both papers] Zucker Hillside Hospital Campus of the Feinstein Institute for Medical Research Lisa A. Pan, M.D. Tyrone D. Cannon, Ph.D. University of Pittsburgh School of Medicine 2012 Young Investigator Grant Yale University 2012 Young Investigator Grant 2006 Distinguished Investigator Grant *Team included: 2006 Ruane Prizewinner and 2001 Distinguished Investigator David A. Brent, M.D. 1997 Independent Investigator Grant

Early Intervention/Diagnostic Tools: Psychosis validated the risk calculator in a separate degree of accuracy as in the original study Next-Generation Treatments: Depression depression go away when he was treated to have this condition, and all those who NEW TOOL CALCULATES PATIENTS’ group of 210 high-risk individuals. Both led by Dr. Cannon. TREATING METABOLIC PROBLEMS for a metabolic abnormality. Pan and her received folinic acid treatment experienced PERSONAL PSYCHOSIS RISK studies were reported July 1 in the Ameri- IMPROVES SYMPTOMS OF SOME PATIENTS colleagues wondered whether such prob- reductions in their depression symptoms. Most people who develop schizophrenia can Journal of Psychiatry. The personal risk calculator, which WITH REFRACTORY DEPRESSION lems might be common among depres- “The remarkably high incidence of action- and other disorders involving psychosis To develop the risk calculator, Dr. Cannon is available online to clinicians and Researchers have discovered that some sion patients. able abnormalities and some evidence of (including some cases of bipolar disorder and his colleagues considered a range of researchers, will allow doctors to better people who suffer from major depression symptom improvement with treatment and depression) experience subtle changes clinical, cognitive, and demographic risk communicate individual risk to patients may benefit from the diagnosis and treat- This provided a basis for their newly strongly support the need for larger stud- in belief, thought, and perception that pre- factors for psychosis. By analyzing data and their families. The researchers say it ment of metabolic deficiencies. reported study, in which the 33 enrollees ies,” the researchers conclude. cede the onset of full psychosis. But fewer from their study group, the team found that will also be valuable in identifying the best suffered from treatment-resistant depres- than 35 percent of people whose symp- experiencing warning symptoms at a young candidates for clinical trials evaluating the Metabolic deficiencies refer to abnormal sion. All affected individuals in the study toms indicate they are at high risk actually age were the strongest indicators that a effectiveness of interventions that aim to levels of the byproducts of basic bodily were between the ages of 14 and 40, and develop full psychosis within three years of clinically high-risk individual would develop prevent psychosis. and cellular functions, in this case as most had begun experiencing depressive the time they are first identified by a doctor full psychosis within two years. Those warn- detected in the blood, plasma, urine, and episodes as children or adolescents. All as being “at risk.” ing symptoms include: having higher levels *More than a dozen NARSAD grantees helped cerebrospinal fluid (which circulates in the had failed to respond to at least three dif- develop and validate the risk calculator. Dr. of unusual thought content and suspicious- Cannon’s team included: 2005 & 2003 Young In- spinal cord and brain). ferent antidepressant medications. Sixteen Now, clinicians can use a new risk calcu- ness, as compared with others, as well as vestigator Carrie E. Bearden, Ph.D.; 1999 & 1992 healthy subjects were also included in the lator to determine the personal risk of lower verbal learning and memory capacity, Young Investigator Kristin Cadenhead, M.D.; In a study involving 33 patients with study, to serve as controls. 1990 Young Investigator Robert Heinssen, Ph.D.; psychosis for any individual in this high-risk slower cognitive processing, and greater treatment-resistant depression, report- Scientific Council Member, 2007 Independent group. According to the researchers who decline in social functioning. Investigator & 2001 Young Investigator Daniel ed August 13 in the American Journal of For each patient, the researchers ana- developed and tested it, their risk calcula- H. Mathalon, M.D., Ph.D.; 1997 Distinguished Psychiatry, investigators found that about lyzed samples of blood, urine, and spinal tor is about as accurate as those that are The researchers incorporated these factors Investigator Thomas H. McGlashan, M.D.; 2004 & two-thirds of those patients had metabolic fluid. The spinal fluid samples revealed 1998 Independent Investigator Larry J. Seidman, now available for cardiovascular disease into the calculator, as well as a few others Ph.D.; Scientific Council Member, 2010 Lieber deficiencies that affect the brain’s ability metabolic abnormalities in 21 of the 33 and cancer. that they found had a smaller impact: family Prizewinner and 1998 Distinguished Investigator to produce neurotransmitters. Patients’ study participants with depression. No history of schizophrenia and the experience Ming T. Tsuang,M.D., Ph.D., D.Sc.; 1989 Distin- depression symptoms declined significant- metabolic abnormalities were found in the guished Investigator Elaine F. Walker, Ph.D.; and A team of scientists* led by Tyrone D. Can- of stressful or traumatic events. 2005 Distinguished Investigator and 1998 Inde- ly when these metabolic problems were healthy subjects. non, Ph.D. at Yale University developed pendent Investigator Scott W. Woods, M.D. treated. For some individuals, depression The research team found several different the risk calculator using data from 596 Dr. Carrión and his team used the calcula- reached remission. metabolic abnormalities among the study Dr. Carrión’s team included 2004 Young Inves- high-risk individuals, 16 percent of whom tor to assess the personal risk of another participants with major depression. The tigator Andrea Auther, Ph.D.;Scientific Council developed psychosis during a two-year 210 individuals in the high-risk category, Member, 2001 Klerman Prizewinner, 2007 A team of researchers led by Lisa A. Pan, most common was a deficiency in cerebral study period. Another team of scientists and found that it was able to distinguish Distinguished Investigator, 1997 & 1994 Young M.D. at the University of Pittsburgh School folate, a condition that can be treated with led by Ricardo E. Carrión, Ph.D., at the individuals who developed psychosis from Investigator, Cameron S. Carter, M.D.; 2012 of Medicine, undertook the study after folinic acid. Twelve of the patients with Young Investigator Tara A. Niendam, Ph.D.; and Feinstein Institute for Medical Research, those who did not with about the same 1996 Young Investigator Stephan F. Taylor, M.D. seeing one 19-year-old man’s unrelenting treat-resistant depression were found

20 ANNUAL REPORT 2016 www.bbrfoundation.org 21 TOP 10 ADVANCEMENTS & BREAKTHROUGHS

2 0 1 6 w e b i n a r s

Dr. Jeffrey Borenstein hosts the “Meet May 10, 2016 October 18, 2016 the Scientist” webinar series where leading PRIMARY PREVENTION IN CHILD A BEAUTIFUL MIND: JOHN NASH, 10 mental health researchers discuss and PSYCHIATRY: THE TRANSFORMATIVE POWER SCHIZOPHRENIA, GAME THEORY AND answer questions about the latest research OF CHILDREN AND FAMILIES RECOVERY FROM SCHIZOPHRENIA WITH Journal: Nature Neuroscience—September, 2016 findings in new technologies, early inter- James F. Leckman, M.D. AND WITHOUT MEDICATION vention strategies and next-generation Yale University School of Medicine Herbert Y. Meltzer, M.D. Pamela B. Sklar, M.D., Ph.D. therapies for mental illness. These popular Scientific Council Member Northwestern University Feinberg School of Medicine Icahn School of Medicine at Mount Sinai webinars offer the general public access to 1993 Distinguished Investigator some of the world’s top scientists who dis- Scientific Council Member Scientific Council Member cuss their cutting-edge research that could June 14, 2016 2007, 2000, 1994 & 1998 Distinguished 2016 Colvin Prizewinner lead to breakthroughs to alleviate the suf- SOCIAL LEARNING IN BORDERLINE Investigator fering caused by mental illness. Webinars PERSONALITY DISORDER 1992 Lieber Prizewinner for Outstanding 2006 Independent Investigator Grant can be seen at bbrfoundation.org/webinar. Sarah Kathryn Fineberg, M.D., Ph.D. Achievement in Schizophrenia Research 1998 & 1995 Young Investigator Grant Yale University February 9, 2016 Scientific Council Member November 8, 2016 Basic Research: Schizophrenia genetic variations associated with schizo- without the illness, using tissue samples EARLY EMERGENCE OF DEPRESSION: 2014 Young Investigator COULD WE SOMEDAY PREVENT RESEARCHERS CATALOG SUBTLE BUT phrenia. This publicly available catalogue collected after patients’ deaths. The analy- UNDERSTANDING RISK FACTORS AND SCHIZOPHRENIA LIKE WE PREVENT WIDESPREAD SCHIZOPHRENIA-ASSOCIATED will markedly facilitate understanding func- sis identified 693 genes whose activity was TREATMENT July 12, 2016 CLEFT PALATE? DIFFERENCES IN GENE ACTIVITY tional effects and underlying mechanisms different in the two groups. The differences Deanna Barch, Ph.D. LIFE ELEVATED: EXAMINING ALTITUDE- Robert R. Freedman, M.D. Researchers have identified nearly 700 across many brain disorders. were subtle, consisting of gains or losses of Washington University in St. Louis RELATED EFFECTS ON MENTAL ILLNESS University of Colorado School of Medicine genes whose activity levels differ in the up to about 33 percent of activity. Foundation Scientific Council Member Perry F. Renshaw, M.D., Ph.D. Foundation Scientific Council Member brains of people with schizophrenia Major clues into the genetic origins of the 2013 Distinguished Investigator University of Utah 2015 Lieber Prizewinner for Outstanding compared to individuals without the schizophrenia came in 2014, when a team Notably, Dr. Sklar and her colleagues used 2006 Independent Investigator Scientific Council Member Achievement in Schizophrenia Research disorder. Most of the differences they of scientists from the Psychiatric Genom- their well-powered catalogue to identify the 2000, 1995 Young Investigator 2000 Independent Investigator 1999, 2006 Distinguished Investigator found were subtle, consistent with the ics Consortium analyzed the DNA of more likely genes responsible for the associations 1996, 1993 Young Investigator idea that variations in many genes than 140,000 people, including 37,000 with with schizophrenia in 19 of the 108 genome March 15, 2016 December 13, 2016 contribute to the risk of schizophrenia, the disorder. That study associated DNA locations found in the 2014 study. These ADOLESCENTS WITH BIPOLAR DISORDER: August 9, 2016 NEUROINFLAMMATORY HYPOTHESES OF each alone having a small effect. variation at 108 regions in the genome to genes are particularly likely to be relevant TIPS ON COPING FOR FAMILIES AUTISM: UNDERSTANDING THE CAUSES DEPRESSION schizophrenia although it could not pin- to schizophrenia’s effects on brain function, David J. Miklowitz, Ph.D. AND DEVELOPING EFFECTIVE TREATMENTS Yvette I. Sheline, M.D. Many of the genes identified in the analysis point specific genes. the researchers say. UCLA Semel Institute Jacqueline N. Crawley, Ph.D. University of Pennsylvania Perelman fall within DNA regions that were associated 2011 Colvin Prizewinner for Outstanding University of California Davis School of School of Medicine with schizophrenia in a large genome-wide In the new study, a team of researchers led Dr. Sklar and her colleagues used their data Achievement in Mood Disorder Research Medicine, Sacramento Foundation Scientific Council Member association study reported in 2014. Such by Pamela B. Sklar, M.D., Ph.D., took a com- to identify several genes for follow-up stud- 2001 Distinguished Investigator Scientific Council Member 2005, 2002 Independent Investigator studies look for genetic variations seen plementary approach to understanding the ies in animals. They manipulated the activi- 1987 Young Investigator 1998 Young Investigator frequently across large numbers of people, origins of the disorder. Instead of compar- ty of five of the schizophrenia-linked genes September 13, 2016 both healthy people and those diagnosed ing DNA sequences in people with and within zebrafish (a “model organism” often April 12, 2016 LIVING WELL WITH ADHD: SCIENTIFIC with a particular illness. out the mental illness, the team examined used for genetics experiments), and found LEVERAGING NOVEL CONCEPTS OF GUIDEPOSTS TO IMPROVED OUTCOMES in people with and without schizophrenia three genes whose alteration disrupted RECEPTOR BIOLOGY TOWARD A BETTER F. Xavier Castellanos, M.D. The new findings, published September 26 the activity of genes within the brain. brain development. Other researchers can TREATMENT FOR SCHIZOPHRENIA NYU Child Study Center in the journal Nature Neuroscience, report now extend the team’s findings by further Marc G. Caron, Ph.D. 2015 Ruane Prizewinner for Outstanding the largest catalogue of genetic influences Their experiments compared levels of exploring genes on the list to begin teasing Duke University Medical Center Achievement in Child and Adolescent on brain gene expression and begin to illu- gene activity in the brains of 258 people out the molecular basis of schizophrenia. Scientific Council Member Psychiatric Research minate the biological consequences such with schizophrenia to that of 279 people 2005 Distinguished Investigator

22 ANNUAL REPORT 2016 www.bbrfoundation.org 23 SCIENTIFIC Karl Deisseroth, M.D., Ph.D. John H. Krystal, M.D. Kerry J. Ressler, M.D., Ph.D. COUNCIL J. Raymond DePaulo, Jr., M.D. Amanda Law, Ph.D. Carolyn B. Robinowitz, M.D. Ariel Y. Deutch, Ph.D. James F. Leckman, M.D. Bryan L. Roth, M.D., Ph.D. PRESIDENT Wayne C. Drevets, M.D. Francis S. Lee, M.D., Ph.D. John L.R. Rubenstein, Herbert Pardes, M.D. Ronald S. Duman, Ph.D. Ellen Leibenluft, M.D. M.D., Ph.D. Stan B. Floresco, Ph.D. Robert H. Lenox, M.D. Bernardo Sabatini, M.D., VICE PRESIDENT EMERITUS Judith M. Ford, Ph.D. Pat Levitt, Ph.D. Ph.D. Floyd E. Bloom, M.D. Alan Frazer, Ph.D. David A. Lewis, M.D. Gerard Sanacora, M.D., o u r Robert R. Freedman, M.D. Jeffrey A. Lieberman, M.D. Ph.D. Ted Abel, Ph.D. Fred H. Gage, Ph.D. Irwin Lucki, Ph.D. Akira Sawa, M.D., Ph.D. Anissa Abi-Dargham, M.D. Aurelio Galli, Ph.D. Gary Lynch, Ph.D. Alan F. Schatzberg, M.D. Schahram Akbarian, M.D., Mark S. George, M.D. Robert C. Malenka, M.D., Nina R. Schooler, Ph.D. Ph.D. Elliot S. Gershon, M.D. Ph.D. Robert Schwarcz, Ph.D. Huda Akil, Ph.D. Mark A. Geyer, Ph.D. Anil K. Malhotra, M.D. Philip Seeman, M.D., Ph.D. Susan G. Amara, Ph.D. Jay N. Giedd, M.D. Husseini K. Manji, M.D., Yvette I. Sheline, M.D. Stewart A. Anderson, M.D. Jay A. Gingrich, M.D., Ph.D. FRCPC Pamela Sklar, M.D., Ph.D. Nancy C. Andreasen, M.D., David Goldman, M.D. J. John Mann, M.D. Solomon H. Snyder, M.D., s c i e n t i f i c Ph.D. Frederick K. Goodwin, M.D. John S. March, M.D., M.P.H. DSc, D.Phil. (Hon. Causa) Amy F.T. Arnsten, Ph.D. Joshua A. Gordon, M.D., Daniel Mathalon, Ph.D., M.D. Matthew State, M.D. Gary S. Aston-Jones, Ph.D. Ph.D. Helen S. Mayberg, M.D. Murray Stein, M.D., M.P.H. Jay M. Baraban, M.D., Ph.D. Elizabeth Gould, Ph.D. Robert W. McCarley, M.D. John S. Strauss, M.D. Deanna Barch, Ph.D. Anthony A. Grace, Ph.D. Bruce S. McEwen, Ph.D. J. David Sweatt, Ph.D. Jack D. Barchas, M.D. Paul Greengard, Ph.D. Ronald D.G. McKay, Ph.D. John A. Talbott, M.D. Samuel H. Barondes, M.D. Raquel Gur, M.D., Ph.D. James H. Meador-Woodruff, Carol A. Tamminga, M.D. Francine M. Benes, M.D., Suzanne N. Haber, Ph.D. M.D. Laurence H. Tecott, M.D., Ph.D. Philip D. Harvey, Ph.D. Herbert Y. Meltzer, M.D. Ph.D. c o u n c i l Karen F. Berman, M.D. Stephan Heckers, M.D. Kathleen Merikangas, Ph.D. Ming T. Tsuang, M.D., Ph.D., Wade H. Berrettini, M.D., René Hen, Ph.D. Richard J. Miller, Ph.D. DSc 168 Members (4 Emeritus) Ph.D. Fritz A. Henn, M.D., Ph.D. Karoly Mirnics, M.D., Ph.D. Kay M.Tye, Ph.D. 2 Nobel Prize Winners Randy D. Blakely, Ph.D. Takao Hensch, Ph.D. Bita Moghaddam, Ph.D. Leslie G. Ungerleider, Ph.D. Pierre Blier, M.D., Ph.D. Robert M.A. Hirschfeld, M.D. Dennis L. Murphy, M.D. Rita J. Valentino, Ph.D. 4 Former Directors of the National Institute of Mental Hilary Blumberg, M.D. L. Elliot Hong, M.D. Charles B. Nemeroff, M.D., Jim van Os, M.D., Ph.D., Health as well as the Current Director Robert W. Buchanan, M.D. Steven E. Hyman, M.D. Ph.D. MRCPsych 4 Recipients of the National Medal of Science Peter F. Buckley, M.D. Robert B. Innis, M.D., Ph.D. Eric J. Nestler, M.D., Ph.D. Susan Voglmaier, M.D., Ph.D. William E. Bunney, Jr., M.D. Jonathan A. Javitch, M.D., Andrew A. Nierenberg, M.D. Nora D. Volkow, M.D. 13 Members of the National Academy of Sciences Joseph D. Buxbaum, Ph.D. Ph.D. Patricio O’Donnell, M.D., Mark von Zastrow, M.D., 26 Chairs of Psychiatry & Neuroscience Departments William Byerley, M.D. Daniel C. Javitt, M.D., Ph.D. Ph.D. Ph.D. at Leading Medical Institutions William Carlezon, Ph.D. Dilip Jeste, M.D. Dost Ongur, M.D., Ph.D. Karen Dineen Wagner, M.D., Marc G. Caron, Ph.D. Lewis L. Judd, M.D. Steven M. Paul, M.D. Ph.D. 55 Members of the National Academy of Medicine William T. Carpenter, Jr., M.D. Ned Kalin, M.D. Godfrey D. Pearlson, Daniel R. Weinberger, M.D. Cameron S. Carter, M.D. Peter W. Kalivas, Ph.D. MBBS, M.D. Myrna M. Weissman, Ph.D. BJ Casey, Ph.D. Eric R. Kandel, M.D. Mary L. Phillips, M.D. Marina Wolf, Ph.D. Bruce M. Cohen, M.D., Ph.D. Richard S.E. Keefe, Ph.D. Marina Picciotto, Ph.D. Jared W. Young, Ph.D. Jonathan D. Cohen, M.D., Samuel J. Keith, M.D. Daniel S. Pine, M.D. L. Trevor Young, M.D., Ph.D. Ph.D. Martin B. Keller, M.D. Robert M. Post, M.D. Jon-Kar Zubieta, M.D., Ph.D. Peter Jeffrey Conn, Ph.D. John R. Kelsoe, M.D. James B. Potash, M.D., Edwin Cook, M.D. Kenneth S. Kendler, M.D. M.P.H. MEMBERS EMERITUS Richard Coppola, DSc James L. Kennedy, M.D. Steven G. Potkin, M.D. George K. Aghajanian, M.D. Rui Costa, Ph.D., HHMI Robert M. Kessler, M.D. Pasko Rakic, M.D., Ph.D. Dennis S. Charney, M.D. Joseph T. Coyle, M.D. Kenneth K. Kidd, Ph.D. Judith L. Rapoport, M.D. Jan A. Fawcett, M.D. Jacqueline N. Crawley, Ph.D. Mary-Claire King, Ph.D. Perry F. Renshaw, M.D., John G. Csernansky, M.D. Rachel G. Klein, Ph.D. Ph.D., M.B.A.

24 ANNUAL REPORT 2016 www.bbrfoundation.org 25 Deanna M. Barch, Ph.D. is the Gregory Hilary Blumberg, M.D. is the John and B. Couch Professor of Psychiatry and the Hope Furth Professor of Psychiatric Neuro- Chair of the Department of Psychological science, Professor of Psychiatry, Diagnostic & Brain Sciences at Washington University Radiology and in the Child Center, and o u r n e w e s t in Saint Louis, MO. She was the Editor of Director of the Mood Disorders Research Cognitive, Affective and Behavioral Neurosci- Program, at the Yale School of Medicine. ence, is currently Deputy Editor at Biological Her research is devoted to understanding Psychiatry and is on the Editorial Boards of brain circuitry differences that underlie Schizophrenia Bulletin, Current Directions in mood disorders and the associated high Psychological Science, Journal of Abnormal risk of suicide, and circuitry changes in s c i e n t i f i c Psychology, and Clinical Psychological Science. mood disorders across the lifespan. She Dr. Barch is immediate past President of the brings together a multi-disciplinary group Society for Research in Psychopathology, is of scientists to study the genetic, devel- on the DSM-V Revision Committee, is on the opmental and environmental factors Steering committee for the NIMH Research that cause mood disorders to develop Domain Criteria initiative, and is a member new methods for early detection, more c o u n c i l of the NIMH Scientific Council. Her research effective interventions, and prevention. is focused on understanding the interplay Dr. Blumberg studied neuroscience as an among cognition, emotion, and brain func- undergraduate at Harvard University and tion to better understand the deficits in be- completed her medical degree, psychiatry havior and cognition found in illnesses such training and specialty training in neuroim- as schizophrenia and depression. She uses aging at Cornell University Medical College m e m b e r s functional MRI, structural MRI, and cognitive prior to joining the Yale faculty in 1998. neuroscience methods to examine neural basis of disturbances in cognitive control Led by Dr. Herbert Pardes, the founding and emotional processing in individuals • 2006 Klerman Prize for President of our Scientific Council, the with schizophrenia and those at risk for the Exceptional Clinical Research by all-volunteer group of pre-eminent mental development of schizophrenia, as well as in a Young Investigator health researchers review more than 1,200 individuals with mood disorders. • 2006 Independent Investigator Grant applications each year and select the • 2002 Young Investigator most promising research ideas with the greatest potential to lead to breakthroughs. • 2013 Distinguished Investigator • 2006 Independent Investigator The Scientific Council guides the Foundation • 2000 & 1995 Young Investigator to fund creative and impactful research relevant to the whole spectrum of mental health. We welcome our newest members.

26 ANNUAL REPORT 2016 www.bbrfoundation.org 27 William Carlezon, Ph.D. is Professor of Rui M. Costa, Ph.D. is a Principal Investi- Dilip Jeste, M.D. is the Associate Dean Ned H. Kalin, M.D., is Chairman of the De- Dan Mathalon, Ph.D., M.D. is co-di- Mary L. Philips, M.D. is the Pittsburgh Psychiatry at the Behavioral Genetics Lab gator of the Neurobiology of Action Labo- for Healthy Aging and Senior Care, the partment of Psychiatry at the University of rector of the Brain Imaging and EEG Foundation-Emmerling Endowed Chair at McLean Hospital and also serves as chief ratory at Champalimaud Research (CR) in Estelle and Edgar Levi Chair in Aging, the Wisconsin-Madison, where he is the Director Laboratory at University of California, San in Psychotic Disorders, and Professor in of McLean’s Division of Basic Neuroscience Portugal. Dr. Costa received his D.V.M. from Distinguished Chair of Psychiatry and of the Health Emotions Research Institute Francisco (UCSF). He also directs the Early Psychiatry and Clinical and Translational and a professor of psychiatry at Harvard the Technical University of Lisbon in 1996. Neurosciences, and the Director, Sam and and Lane Neuroimaging Laboratory. He Psychosis Program at UCSF, overseeing Science at the University of Pittsburgh. In Medical School. Dr. Carlezon is known for He entered the GABBA graduate program Rose Stein Institute for Research on Aging has made significant advances in uncover- research and treatment of patients who addition, she heads the Clinical and Trans- his work on the neurobiology of depression from University of Porto in 1997, and at the University of California San Diego. Dr. ing basic brain and molecular mechanisms are in the early phases of psychosis or lational Affective Neuroscience Program in and addiction. His lab has been at the fore- performed his Ph.D. studies at UCLA from Jeste is a geriatric neuropsychiatrist, who that cause children to be vulnerable to de- who are exhibiting prodromal symptoms the Department of Psychiatry. Dr. Phillips’ front of studying the role of dynorphin, the 1998 to 2002 followed by postdoctoral specializes in successful aging, neurobiolo- velop anxiety and depressive disorders. He indicative of increased clinical risk for research focuses on using multimodal endogenous opioid, and its brain receptor work at Duke University. Dr. Costa became gy of wisdom as well as schizophrenia and serves as the principal investigator for sev- psychosis. Dr. Mathalon received his B.A. neuroimaging techniques to elucidate (kappa-opioid receptors) in motivation and a Section Chief at the National Institutes other psychotic disorders in older adults. eral ongoing NIH funded research projects from UC Berkeley and his Ph.D. in Clini- functional and structural abnormalities in emotion. He is currently editor-in-chief of Health in 2006 and in 2009 became an He is the Senior Associate Dean for Healthy and has published widely on the adaptive cal Psychology from Indiana University. emotion processing, reward processing of Neuropsychopharmacology. Dr. Carle- Investigator of the Champalimaud Neuro- Aging and Senior Care at the University and maladaptive expression of emotion He subsequently obtained his M.D. from and emotional regulation circuitries that zon has received several awards for his science Program. He is the President of the of California, San Diego. He has published and anxiety. He is Co-Editor of the Journal Stanford University, where he also com- are associated with specific psychiatric research, including the Presidential Early American-Portuguese Biomedical Research over 600 articles in peer-reviewed journals of Psychoneuroendocrinology. In addition to pleted his psychiatric residency training disorders and symptom dimensions, in in- Career Award for Scientists and Engineers Fund and Vice-President of the Portuguese and 12 books, including Successful Cognitive his research activities, he treats patients and a research fellowship in psychophys- dividuals with mood and anxiety disorders. from George W. Bush, the Jacob P. Waletz- Society for Neuroscience. His laboratory and Emotional Aging (2009), Prevention in who suffer from anxiety and depression iology. In 2000, Dr. Mathalon joined the Her research also focuses on identifying ky Award for Innovative Research in Drug studies the neurobiology of action in health Mental Health (2011), and Positive Psychiatry who are refractory to standard treatment. faculty of the Department of Psychiatry at the neurodevelopmental trajectories in Addiction and Alcoholism from the Society and disease. To study actions is to study (2015). He was listed in “The Best Doctors Dr. Kalin is board certified by the American Yale University. In 2007, he moved to San these circuitries that are associated with for Neuroscience, and the Daniel H. Efron the way we do things, which is different in America” and in the Institute for Scien- Board of Psychiatry and Neurology. He Francisco, establishing the Brain Imaging the development of such disorders in Award from the American College of Neuro- than studying how to remember stimuli, or tific Information’s list of the “world's most has been recognized for numerous awards and EEG Laboratory at UCSF. Dr. Mathalon youth, and the extent to which these neu- psychopharmacology. facts and events. Some actions are innate cited authors.” His work has been featured including, most recently, being elected to has extensive expertise in electroenceph- roimaging techniques can identify biomark- or prewired (such as swallowing or breath- in The New York Times, The Washington Post, the National Academy of Medicine and alographic (EEG) and functional magnetic ers reflecting underlying pathophysiologic ing), but most are learned anew through- The Wall Street Journal, The Atlantic Monthly, becoming a Distinguished Fellow of the resonance imaging (fMRI) methods, and processes that denote future risk for these • 2007 & 2005 Independent Investigator out life, likely through a process of trial Time, National Public Radio, PBS, Public American Psychiatric Association. he has used these methods to study the disorders in as yet unaffected youth. She • 1999 Young Investigator and feedback. Dr. Costa’s laboratory uses Radio International, London Times, and the temporal and anatomical organization of works in collaboration with basic neuro- genetic, electrophysiological, optical, and Colbert Report, among others. Dr. Jeste ob- functional brain activity underlying sen- scientists in translational studies of neural behavioral approaches to investigate the tained his medical education in Pune and sory, perceptual, and cognitive processes circuitry abnormalities in these disorders. mechanisms underlying the generation and Mumbai, India. In the USA, he completed and their dysfunction in neuropsychiatric learning of novel actions. psychiatry residency at Cornell University, disorders. Much of his prior research has and Neurology residency at George Wash- focused on studying the pathophysiologi- • 2005 Independent Investigator ington University. He was a researcher at cal mechanisms underlying the symptoms National Institute of Mental Health before and course of schizophrenia, and a major joining UCSD. He is a member of several focus of his current research is on the prestigious professional organizations, prodromal period preceding the onset of including the Institute of Medicine. He also psychosis. Ultimately, his work aims to use serves as the Editor-in-Chief of the Ameri- neurophysiological biomarkers to enhance can Journal of Geriatric Psychiatry. the accuracy of psychosis risk prediction, providing a stronger justification for early interventions with individuals at clinical • 2002 Distinguished Investigator high risk for psychosis.

• 2007 Independent Investigator • 2001 Young Investigator

28 ANNUAL REPORT 2016 www.bbrfoundation.org 29 BY THE NUMBERS SINCE 1987 As of December

AWARDED TO SIENTISTS

Kay Tye, Ph.D. is an Assistant Professor of Marina Wolf, Ph.D. is Professor and Chair $360 MILLION Neuroscience at The Picower Institute for of the Department of Neuroscience at the Learning and Memory in the Department Chicago Medical School of Rosalind Franklin GRANTS The breakdown of our grantees since 198 of Brain and Cognitive Sciences at the University of Medicine and Science. She has Massachusetts Institute of Technology. Dr. Tye been a pioneer in studying the role of Young Investigators ultimately seeks to crack the neural code neuronal plasticity in drug addiction. Dr. 4,086 of anxiety and gain new insight towards ef- Wolf received her Ph.D. in Pharmacology in 788 Independent Investigators fectively treating these disorders. Dr. Tye’s 1986 from Yale University. From 1987-1990, 409 Distinguished Investigators research focuses on understanding the she trained as a Postdoctoral Fellow at the neural circuits important for processing Center for Cell Biology at Sinai Hospital of positive and negative emotional valence Detroit. After completing her postdoctoral and how this gives rise to motivated behav- training, Dr. Wolf was Assistant Professor 5,000 iors. Dr. Tye received her bachelor’s degree of Psychiatry at Wayne State University in Brain and Cognitive Sciences from MIT in until moving in 1992 to the Chicago Medical 2003 and earned her Ph.D. in 2008 at the School. Dr. Wolf has served as a member University of California, San Francisco. Her of the NIDA Advisory Council and the NIH UNIVERSITIES & MEDIAL ENTERS OUNTRIES, INLUDING THE US thesis work was supported by the National Council of Councils. She presently serves Science Foundation and recognized with as Chair of a National Institute of Health the Lindsley Prize in Behavioral Neurosci- study section, as well as on the National ence as well as the Weintraub Award in Institute of Drug Abuse Board of Scientific Biosciences. She completed her postdoc- Counselors and the Council of the Ameri- toral training with fellow Council member, can College of Neuropsychopharmacology. Dr. Karl Deisseroth at Stanford University in 2011, with support from an NRSA from NIMH. She has been recognized with • 2006 Distinguished Investigator 541 35 the NIH Director’s New Innovator Award, • 1999 Independent Investigator Technology Review’s Top 35 Innovators • 1990 Young Investigator under 35, and has been named a Whitehall, 168 ATIVE SIENTIFI OUNIL MEMBERS AND EMERITUS MEMBERS Klingenstein and Sloan Foundation Fellow. The all-volunteer Foundation Scientiﬁc The group includes: Council is composed of 168 leading 55 Members of the National Academy of Medicine experts across disciplines in brain & • 2016 Freedman Prize for Exceptional 26 hairs of Psychiatry & Neuroscience Departments behavior research who review grant Basic Research by a Young Investigator 13 Members of the National Academy of Sciences applications and recommend the • 2013 Young Investigator 4 Recipients of the National Medal of Science most promising ideas to fund 4 Former Directors of the National Institute of Mental Health and the urrent Director 2 Nobel Prize Winners

bbrfoundationorg

30 ANNUAL REPORT 2016 www.bbrfoundation.org 31 SINCE 1987, THE FOUNDATION HAS AWARDED MORE THAN $360 MILLION TO FUND MORE THAN 5,000 GRANTS TO MORE THAN 4,000 LEADING SCIENTISTS AROUND THE WORLD. 2 0 1 6 Our Grants support a broad range of the best ideas in brain research. Funding is focused on four priority areas to better understand and treat mental illness:

BASIC RESEARCH YOUNG INVESTIGATOR GRANTS To understand what happens in the brain • Initiated in 1987. to cause mental illness. • Help researchers launch careers in investments neuroscience and psychiatry and NEW TECHNOLOGIES gather pilot data to apply for larger To advance or create new ways of studying federal and university grants. and understanding the brain. • Up to $70,000 for two years. • More than $243 million funded. DIAGNOSTIC TOOLS/EARLY INTERVENTION i n r e s e a r c h To recognize early signs of mental illness In 1987 the Foundation awarded $250,000 and treat as early as possible. in Young Investigator Grants to its first 10 early career scientists at $25,000 each to NEXT GENERATION THERAPIES fund their promising research ideas. To reduce symptoms of mental illness and retrain the brain. Foundation grant recipients have gone on g r a n t s to receive more than $3.5 billion in addi- DISTINGUISHED INVESTIGATOR GRANTS tional research funding in next stage NIMH • Initiated in 1988. and NIH grants. • Enable outstanding scientists to pursue new, cutting edge ideas with the No other organization outside of the fed- greatest potential for breakthroughs. eral government has funded the number • $100,000 for one year. of mental health research grants that the • More than $39 million funded. Foundation has—or been responsible for more breakthroughs in the field. INDEPENDENT INVESTIGATOR GRANTS • Initiated in 1995. An independent measure of the success of • Support mid-career scientists during our grants is in a recent RAND Europe anal- the critical period between initiation ysis of the global mental health research of research and receipt of sustained funding landscape over the past five years. funding. This report found that we are the top • Up to $100,000 for two years. non-government mental health research • More than $77 million funded. funder mentioned in published articles.

32 ANNUAL REPORT 2016 www.bbrfoundation.org 33 distinguished independent investigators investigators 152 Applications | 15 Grants | $1,500,000 Awarded 326 Applications | 40 Grants | $3,900,000 Funded

The Distinguished Investigator Grants pro- “The Brain & Behavior Research Foundation’s Ground-breaking scientists already proven “The Independent Investigator Grants provide vide support for experienced investigators Grants are remarkable because they serve as in their field receive the Independent outstanding basic and clinical scientists with (full professor or equivalent) conducting seed capital for new approaches that might Investigator Grant. These scientists seek unique opportunities to conduct important, neurobiological and behavioral research. otherwise go unfunded. This year, we received to produce experimental results that novel, and clinically relevant studies. These One-year grants of $100,000 each are a large number of outstanding proposals with will put them in a position to initiate studies are not being funded through the provided for established scientists pursuing the potential to inform several illnesses, reveal major research programs. This support traditional NIMH mechanisms because of a particularly innovative project ideas. new neurobiological or behavioral targets for comes at the critical middle period in the shortage of money, and in some cases risk potential treatment, explore exciting new basic investigators’ careers–the phase between aversion. I believe that many of these grants Distinguished Investigator Grants fund tal- science, pursue translational scholarship and the initiation of research and the receipt will help open new vistas in treating major ented, established scientists with a record multidisciplinary collaborations, and conduct of sustained funding. With proven success psychiatric illnesses and understanding them of outstanding research accomplishments. new early treatment trials that center on new as highly productive scientists, they seek better. The Foundation has been heroic in These research projects might provide new approaches or ways to combine treatment.” to make clinically relevant advances in the raising the funds for so many extraordinary approaches to understanding or treating study and treatment of a range of brain grants each year, so it is gratifying for me and severe mental illness. If successful, the JACK D. BARCHAS, M.D. and behavior disorders. an honor to help distribute these funds in the grants could result in later funding from best way possible.” Chair, Distinguished Investigator other sources. These grants are among the Independent Investigator Grants provide Selection Committee most competitive in mental health research each scientist with $50,000 per year for ROBERT M. POST, M.D., PH.D. and demonstrate the power investigator-ini- Founding Member of the Foundation’s up to two years to support their work Chair, Independent Investigator Selection tiated research for bringing out new and Scientific Council during the critical period between the Committee Foundation creative ideas. start of the research and the receipt of Chair and Barklie McKee Henry Professor Scientific Council Member of Psychiatry sustained funding. Weill Cornell Medical College Head, Bipolar Collaborative Network This year’s 40 Independent Investigator Psychiatrist-in-Chief Professor of Psychiatry grantees represent an exciting group of Weill Cornell Medical Center, George Washington School of Medicine basic and clinical proposals which should NewYork-Presbyterian Hospital make major contributions to the better un- and Payne Whitney Clinic derstanding and treatment of serious psychiatric illness. 326 grants were reviewed by 60 members of the Scientific Council.

34 ANNUAL REPORT 2016 www.bbrfoundation.org 35 y o u n g investigators 761 Applications | 198 Grants | $13,700,000 Funded 2 0 1 6 g r a n t s Young Investigator Grants cover a broad “Young Investigator Grants have led to ground- spectrum of mental illnesses and serve as breaking and important new research that catalysts for additional funding, providing has improved the lives of people living with researchers with “proof of concept” for mental illness, through enhanced treatments their work. The Foundation awarded a total and therapies, and a better understanding of of $13.7 million to its 2016 Young Inves- the causes of mental illness. These early career tigators, strengthening its investment in scientists are making great strides in basic the most promising ideas to lead advance- research, new technologies, next generation b y i l l n e s s ments in understanding and treating brain therapies and early intervention techniques. and behavior disorders. This is the kind of out of the box research that will offer the best hope for change.” Young Investigator Grants provide each —Herbert Pardes, M.D. scientist with $35,000 per year for two President of the Scientific Council years totaling $70,000 to enable promising Executive Vice Chairman of the Board of investigators to either extend research Trustees, NewYork-Presbyterian Hospital fellowship training or begin careers as independent research faculty.

JUDY M. FORD, PH.D. SUZANNE N. HABER, PH.D. Co-Chair of the Young Investigator Co-Chair of the Young Investigator Grant Selection Committee Grant Selection Committee Foundation Scientific Council Member Foundation Scientific Council Member 2003 Independent Investigator 2011 Distinguished Investigator Professor, Department of Psychiatry Professor, Department of University of California, San Francisco Pharmacology and Physiology University of Rochester Medical Center

36 ANNUAL REPORT 2016 www.bbrfoundation.org 37 a d d i c t i o n a n x i e t y

Foundation grantees are among the pio- One grantee is using imaging in a longitudi- Anna B. Konova, Ph.D. Discoveries by Foundation grantees have Thackery Ian Brown, Ph.D. neers in understanding addiction’s roots nal study to compare the brains of identical New York University demonstrated that the brain is much more Stanford University in biology–how the brain’s reward circuit- twins who differ on alcohol use/abuse, to Young Investigator Grant–Basic Research resilient–“plastic”–than once believed, an Young Investigator Grant–Basic Research ry is modified by exposure to addictive discover whether brain anomalies are the important ray of hope for those living with substances, and how risk of becoming cause or consequence of alcohol abuse. Vivek Kumar, Ph.D. anxiety disorders. Bridget Laura Callaghan, Ph.D. addicted varies among individuals, partly A grantee is now studying the efficacy of The Jackson Laboratory Columbia University as a function of biological differences. ketamine in specifically treating depression Young Investigator Grant–Basic Research Grantee research has revealed what Young Investigator Grant–Basic Research among individuals with a family history of happens when stress, both traumatic and Long-lasting cocaine-induced changes alcohol abuse. Another grant seeks to im- Yao-Ying Ma, M.d., Ph.D. chronic, affects an individual at different Yoon-Hee Cha, M.D. in neural network function and behaviors prove treatment of veterans who consume State University of New York, Binghamton times in life. Laureate Institute for Brain Research have been shown by grantees to change alcohol at hazardous levels. Young Investigator Grant–Basic Research Young Investigator Grant–Next Generation patterns of gene expression, as well as Early in life the brain is most plastic, but also Therapies patterns of epigenetic regulation of Rachel Alison Adcock, M.D., Ph.D. Mary-Louise Risher, Ph.D. most vulnerable. Stress can cause shrink- genes. Gene products and epigenetic Duke University Duke University Medical Center age in the hippocampus region, though the Johannes Gräff, Ph.D. marks are therefore potential targets Independent Investigator Grant–Next Young Investigator Grant–Basic Research impact is not necessarily permanent, in part EPFL-École Polytechnique for future treatments. Generation Therapies due to another breakthrough discovery by Fédérale de Lausanne, Switzerland Dorothy Jean Yamamoto, Ph.D. grantees, of the birth of new neurons in the Independent Investigator Grant–Basic Rigorous study by grantees of the long- Pinar Ayata, Ph.D. University of Colorado, Denver hippocampus throughout the lifespan, a Research term effects of marijuana on the brain Icahn School of Medicine at Mount Sinai Young Investigator Grant–Basic Research process called neurogenesis. have identified changes in grey matter Young Investigator Grant–Basic Research Andrew Tapper, Ph.D. volume and connectivity in white mat- Yingjie Zhu, Ph.D. Anxiety disorders in young people have University of Massachusetts ter; launched pioneering studies of the Paul Leon Brown, Ph.D. Stanford University been a strong focus of grantee research. Independent Investigator Grant–Basic danger of heavy or chronic marijuana use University of Maryland Young Investigator Grant–Basic Research Grantees have helped prove the efficacy Research by young people at risk of psychosis; and Young Investigator Grant–Basic Research and safety of SSRI antidepressants in treat- studies of how the brain changes following ing pediatric anxiety. cessation of addictive drug use. Grantees Silvia De Santis, Ph.D. have studied the causes of nicotine addic- Cardiff University, UK Grantees are now testing cutting-edge tion among people with schizophrenia. Young Investigator Grant–New treatments in mice using gut bacteria to Technologies boost immune system and prevent abnor- Adolescent alcohol misuse has been mal sensitivity to stress, and hence develop- associated by grantees with a variety of Maged Harraz, Ph.D. ment of anxiety symptoms. brain structure and function anomalies, Johns Hopkins University e.g., loss of frontal cortex neurons and Young Investigator Grant–Basic Research disruptions in hippocampal plasticity.

38 ANNUAL REPORT 2016 www.bbrfoundation.org 39 a t t e n t i o n – BBRF grantees led a historic longitudinal study following over 200 children with ADHD over more than 30 years, revealing adverse outcomes later in life of youth whose attention and conduct disorders are not recognized and treated.

Grantees helped to establish safety and treatment guidelines for d e f i c i t the prescription of stimulants to treat ADHD. Grantees played an important role in the Multi-modal Treatment Study, the most comprehensive study to date of treatments for ADHD, which showed the superior effectiveness of medication combined with talk therapy versus either treatment alone. hyperactivity Recently a grantee discovered that people diagnosed with ADHD as adults are rarely among those diagnosed during childhood, leading to new research aimed at distinguishing differences in the childhood and adult forms of the disorder.

Other funded research is pursuing genetic clues and evidence of d i s o r d e r strong biological and clinical overlap with other brain disorders that first show in childhood, such as autistic spectrum disorder, communication and learning difficulties.

Gustavo Adolfo Angarita, M.D. a d h d Yale University ( ) Young Investigator Grant–Next Generation Therapies

Jessica A. Church-Lang, Ph.D. University of Texas, Austin Young Investigator Grant–Basic Research

Pamela K. Douglas-Gutman, Ph.D. University of California, Los Angeles Young Investigator Grant–Basic Research

Yuwen Hung, Ph.D. Massachusetts Institute of Technology Young Investigator Grant–Basic Research

Matthew Lovett-Barron, Ph.D. Stanford University Young Investigator Grant–Basic Research

Kristina A. Neely, Ph.D. Pennsylvania State University, Young Investigator Grant–Basic Research

40 ANNUAL REPORT 2016 www.bbrfoundation.org 41 Foundation grantees have been prominent Anahita Amiri, Ph.D. Zhitao Hu, Ph.D. Lukas Ian Schmitt, Ph.D. in the genetic analysis of autism and Autism Yale University University of Queensland, Australia New York University Spectrum Disorder (ASD). Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research

A recent landmark study identified over Laura Christiana Andreae, Ph.D. Michele Nerissa Insanally, Ph.D. Oleksandr (Alex) Shcheglovitov, Ph.D. 300 rare, non-inherited gene mutations King’s College London, UK New York University University of Utah that play a major causative role in a subset Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research of patients. Other analyses of much larger patient populations have attempted to Abhishek Banerjee, Ph.D. Matthew Daniel Lerner, Ph.D. Stephen Edward Paucha Smith, Ph.D. identify commonly occurring mutations University Hospital Zurich, Switzerland Stony Brook University School of Medicine Seattle Children’s Research Institute a u t i s m contributing to autism risk. Of genes Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research implicated to date, some of the strongest candidates affect synapse formation and Helen S. Bateup, Ph.D. April Robyn Levin, M.D. Hume Akahori Stroud, Ph.D. gene expression in the developing brain. University of California, Berkeley Children’s Hospital in Boston Harvard Medical School Young Investigator Grant–Basic Research Young Investigator Grant–Diagnostic Tools/ Young Investigator Grant–Basic Research Other grantees, looking at brain anomalies Early Intervention in autism, have found significant overabun- Maria Chahrour, Ph.D. Meagan Ruth Talbott, Ph.D. dance of synapses in postmortem brains University of Texas-Southwestern Medical Harold Duncan Macgillavry, Ph.D. University of California Davis Medical Center of young people diagnosed with autism. Center at Dallas Utrecht University, Netherlands Young Investigator Grant–Next Generation Pruning of synapses is a key event very Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research Therapies early in life. Robert Wayne Emerson, Ph.D. Jessica Mariani, Ph.D. Yesser Hadj Belgacem Tellier, Ph.D. Children with ASD often start their lives with University of North Carolina, Chapel Hill Yale University University of California, Davis delayed language development; grantees Young Investigator Grant–Diagnostic Tools/ Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research have found a link between language devel- Early Intervention opment in affected children and the activity Ligia Assumpcao Papale, Ph.D. Ying Yang, Ph.D. of certain brain regions. Brain scans and Peter Gregory Enticott, Ph.D. University of Wisconsin, Madison Stanford University skills testing could help predict an autistic Deakin University, Australia Young Investigator Grant–Basic Research Young Investigator Grant–New child’s language development. Independent Investigator Grant–Next Technologies Generation Therapies Tiziano Pramparo, Ph.D. Other grantees have pioneered iPSC University of California, San Diego (induced pluripotent stem cell) technology, Harrison Wren Gabel, Ph.D. Young Investigator Grant–Diagnostic Tools/ which has enabled the reprograming of skin Washington University Early Intervention cells sampled from autism patients. The Young Investigator Grant–Basic Research cells redevelop as neurons, making possible Zhenghan Qi, Ph.D. a range of novel experiments showing what Christos G. Gkogkas, Ph.D. Massachusetts Institute of Technology may be the earliest autism-related patholo- University of Edinburgh, UK Young Investigator Grant–Basic Research gies in nerve cells as the brain develops. Young Investigator Grant–New Technologies Maximiliano Rapanelli, Ph.D. Also at the leading edge are grantees using Rocco George Gogliotti, Ph.D. Yale University the gene-editing tool CRISPR to modify Vanderbilt University Young Investigator Grant–Basic Research genomes of cells to recreate copy number Young Investigator Grant–Basic Research variations thought to contribute to or Krishanu Saha, Ph.D. cause ASD; in separate studies, these cells Elizabeth Heron, Ph.D. University of Wisconsin, Madison can be transplanted in animals to observe Trinity College Dublin, Ireland Young Investigator Grant–New impact on brain and nervous system Young Investigator Grant–Basic Research Technologies development as well as behavior during adolescence and adulthood. Bruce e. Herring, Ph.D. Dorothy Schafer, Ph.D. University of Southern California University of Massachusetts Medical School Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research

42 ANNUAL REPORT 2016 www.bbrfoundation.org 43 b i p o l a r

Foundation Grantees have studied genetic Ana Cristina Andreazza, Ph.D. Manpreet Kaur Singh, M.D. liabilities in people with bipolar disorder, Centre for Addiction and Mental Health, Stanford University d i s o r d e r most closely in families that have been University of Toronto, Canada Independent Investigator Grant–Basic affected over multiple generations. Recently Independent Investigator Grant–Basic Research funded grantees have aimed to discover Research early neural system markers that will make Rupali Srivastava, Ph.D. it possible to differentiate bipolar disor- Benedikt Lorenz Amann, M.D., Ph.D. Johns Hopkins University der from schizophrenia; are investigating FIDMAG Research Foundation (Fundació per Young Investigator Grant–Basic Research immunological abnormalities that may a la Investigació I la Docència Maria Angustias contribute to the mania and mood fluctua- Giménez), Spain Laura Stertz, Ph.D. tions characteristic of bipolar disorder; are Independent Investigator Grant–Next University of Texas Health Science Center, studying the effects of bright light therapy Generation Therapies Houston to treat bipolar depression; evaluating how Young Investigator Grant–Basic Research DNA oxidative damage can modify DNA Alessandro Colasanti, M.D., Ph.D. methylation patterns in bipolar disorder King’s College London, UK Jun-Feng Wang, M.D., Ph.D. and how that changes gene expression Young Investigator Grant–Basic Research University of Manitoba, Canada patterns; leveraging fMRI imaging studies Independent Investigator Grant–Basic showing that adults with bipolar disorder Peter L. Franzen, Ph.D. Research have altered neural activity and connectivity University of Pittsburgh compared to healthy controls to compare Independent Investigator Grant–Next brain-behavioral alterations in youths with Generation Therapies bipolar disorder to those in adults with the illness; and are using advanced imaging to Keming Gao, M.d., Ph.D. find underlying molecular and neural mech- Case Western Reserve University anisms that might allow early diagnosis, Independent Investigator Grant–Next including identifying the biological hallmarks Generation Therapies of hypomania–a weak form of mania that often precedes a first episode of full mania. Jasmin Lalonde, Ph.D. Massachusetts General Hospital and Harvard A recent grantee discovered the breast University cancer drug tamoxifen can greatly reduce Young Investigator Grant–Basic Research manic symptoms in bipolar disorder. Roel A. Ophoff, Ph.D. Grantees have performed some of the University of California, Los Angeles early demonstrations that the rapid-acting Distinguished Investigator Grant–Basic antidepressant ketamine can resolve treat- Research ment-resistant bipolar depression. Sergi Papiol, Ph.D. A recent grantee demonstrated that lithium Ludwig-Maximilians University, Munich, use is linked to lower incidence of dementia Germany is older people with bipolar disorder. Young Investigator Grant–Diagnostic Tools/ Early Intervention

44 ANNUAL REPORT 2016 www.bbrfoundation.org 45 A grantee has established the efficacy of Kirsten A. Donald, M.D. Hee-Dae Kim, Ph.D. combined drug treatment in alleviating University of Cape Town, South Africa University of Arizona geriatric depression. Several grantees have Independent Investigator Grant–Basic Young Investigator Grant–New studied the efficacy of omega-3 supple- Research Technologies ments in relieving depression, particularly in people with elevated levels of bodily Vincent P. Ferrera, Ph.D. Mary Claire Kimmel, M.D. inflammation. Columbia University University of North Carolina at Chapel Hill Independent Investigator Grant–New Young Investigator Grant–Basic Research A grantee recently has used PET imaging Technologies to identify brain activity that may predict Brent Michael Kious, M.D., Ph.D. whether patients with MDD will respond Sjoerd Jehannes Finnema, University of Utah better to antidepressant drugs or Ph.D., Pharm.D. Young Investigator Grant–Next Generation psychotherapy. Yale University Therapies d e p r e s s i o n Young Investigator Grant–Next Generation Aaron Samuel Andalman, Ph.D. Therapies Maria Lindskog, Ph.D. Foundation Scientific Council Members helped establish the prev- Stanford University Karolinska Institute, Sweden alence and recurrent nature of depression, and Foundation grants Young Investigator Grant–Basic Research Nils Christian Gassen, Ph.D. Independent Investigator Grant–Next have helped bring new treatments to patients, beginning with the Max-Planck Institute for Psychiatry, Germany Generation Therapies validation of Interpersonal Psychotherapy (IPT). Jay M. Baraban, M.D., Ph.D. Young Investigator Grant–Basic Research Johns Hopkins University School of Medicine Jie Liu, Ph.D. A grantee developed and validated transcranial magnetic Distinguished Investigator Grant–Basic Albert Giralt, Ph.D. Columbia University stimulation (TMS) for treatment of treatment-resistant Research French Institute of Health and Medical Young Investigator Grant–Basic Research depression, approved by the FDA in 2008. Another grantee Research (INSERM), France has pioneered deep brain stimulations (DBS) for treatment of Olivier Berton, Ph.D. Young Investigator Grant–Basic Research Jenna Ann Mchenry, Ph.D. refractory depression. Icahn School of Medicine at Mount Sinai University of North Carolina at Chapel Hill Independent Investigator Grant–Next Ye Han, Ph.D. Young Investigator Grant–Basic Research Grantees were involved in a historic longitudinal study establish- Generation Therapies Northwestern University ing the negative impact of depression in mothers on children’s Young Investigator Grant– Caroline Menard, Ph.D. mental health, as well as on the greater risk of depression in wom- Clémentine Bosch-Bouju, Ph.D. Next Generation Therapies Icahn School of Medicine at Mount Sinai en over the lifespan. Universite Bordeaux II, France Young Investigator Grant–Basic Research Young Investigator Grant–Next Xuejun Hao, Ph.D. Grantees have sought new ways of recognizing and treating peri- Generation Therapies Columbia University Janitza Liz Montalvo-Ortiz, Ph.D. natal and perimenopausal depression. Grants helped make pos- Young Investigator Grant–Diagnostic Tools/ Yale University sible the discovery that thinning of the brain’s right hemisphere Ki Sueng Choi, Ph.D. Early Intervention Young Investigator Grant–Basic Research correlates with elevated depression risk and supported the Emory University demonstration that reducing serotonin 1A receptors can sensitize Young Investigator Grant–Diagnostic Tools/ Elizabeth A. Heller, Ph.D. David Elliot Moorman, Ph.D. SSRI non-responders to respond to these medications. Early Intervention University of Pennsylvania University of Massachusetts Medical School Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research Grantees led the famous Great Smoky Mountain Study, establish- Ipek Yalcin Christmann, Ph.D., Pharm.D. ing a link between low birthweight and post-puberty depression; Centre National de la Recherche Georgia Eve Hodes, Ph.D. Sho Moriguchi, M.D. led pathbreaking research into the identification of ketamine as a Scientifique (CNRS), University Pierre & Icahn School of Medicine at Mount Sinai University of Toronto, Canada rapidly acting antidepressant, and are now leading trials demon- Marie Curie, France Young Investigator Grant–Basic Research Young Investigator Grant–Next strating its utility in specific care contexts and patient subgroups. Young Investigator Grant–Basic Research Generation Therapies Carrie Holmberg, M.D., Ph.D. Recently grantees identified a ketamine metabolite as a possibly Christine Delorenzo, Ph.D. Stanford University Peter Nageleå, M.D. safer substitute for the drug. A grantee demonstrated the effec- Stony Brook University School of Medicine Young Investigator Grant–Basic Research Washington University, St. Louis tiveness of brief course of psychotherapy in helping mothers with Independent Investigator Grant–Basic Independent Investigator Grant– major depression, and leading to better mental health outcomes Research Paul Holtzheimer, M.D. Next Generation Therapies in their children. The ability to relieve refractory depression in Dartmouth-Hitchcock Medical Center patients with metabolic disorders has now been identified by Independent Investigator Grant–Next grantees, via analysis of cerebrospinal fluid. Generation Therapies

46 ANNUAL REPORT 2016 www.bbrfoundation.org 47 Alexander R. Nectow, Ph.D. Jaclyn Marie Schwarz, Ph.D. Princeton University University of Delaware Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research

Yuliya Nikolova, Ph.D. Etienne L. Sibille, Ph.D. Centre for Addiction and Mental Health, Centre for Addiction and Mental University of Toronto, Canada Health, Canada Young Investigator Grant–Basic Research Distinguished Investigator Grant–Basic Research Desmond Jay Oathes, Ph.D. University of Pennsylvania Adam Philip Stern, M.D. Young Investigator Grant– Harvard Medical School Next Generation Therapies Young Investigator Grant– e a t i n g Next Generation Therapies Jocelien Danielle Attalie Olivier, Ph.D. University of Groningen, Netherlands Maggie M. Sweitzer, Ph.D. Young Investigator Grant–Basic Research Duke University Medical Center Young Investigator Grant–Basic Research Bin Pan, M.d., Ph.D. Medical College of Wisconsin Samuel Wilkinson, M.D. Young Investigator Grant–Basic Research Yale University School of Medicine d i s o r d e r s Young Investigator Grant– Shenfeng Qiu, M.D., Ph.D. Next Generation Therapies University of Arizona A recent Foundation grantee is studying are in part controlled by the neurotrans- Haijiang Cai, Ph.D. Young Investigator Grant–Basic Research Nolan Ryan Williams, M.D. the use of intranasal oxytocin in the treat- mitter acetylcholine. Receptors that brain University of Arizona Stanford University ment of anorexia. Another recently demon- cells use to recognize and respond to Young Investigator Grant–Basic Research Karina Quevedo, Ph.D. Young Investigator Grant– strated that women with anorexia have acetylcholine can also be activated by nic- University of Minnesota Next Generation Therapies below-average activity in brain regions otine, suggesting that this brain circuit may Frank Julius Meye, Ph.D. Young Investigator Grant– that help coordinate social behavior. She also be involved in conveying nicotine’s Rudolf Magnus Institute of Neuroscience, Next Generation Therapies Eric Steven Wohleb, Ph.D. also showed that women with the disorder appetite-suppressing effects, and hinting Utrecht University, Netherlands Yale University School of Medicine tended to blame themselves more than at alternate ways to modify it. Young Investigator Grant–Basic Research Marcia J. Ramaker, Ph.D. Young Investigator Grant–Basic Research others for negative social interactions, thus University of California, San Diego highlighting social deficits as an important Using optogenetics, a revolutionary Nadia Micali, M.D., Ph.D., M.Sc. Young Investigator Grant–Next Bun Yamagata, M.D., Ph.D. target for treating anorexia. technology invented by a grantee, another Icahn School of Medicine at Mount Sinai Generation Therapies Keio University, Japan grantee shined laser light into the mouse Independent Investigator Grant– Young Investigator Grant–Basic Research At a basic biological level, grantees have brain to discover the involvement of New Technologies Matthew James Robson, Ph.D. traced brain circuits involved in feeding neurons in the prefrontal cortex that have Florida Atlantic University Timothy York, Ph.D. behaviors, feelings of hunger and of full- docking ports called D1 receptors on their Jessica Werthmann, Ph.D. Young Investigator Grant–Basic Research University of British Columbia, Canada ness. These have led to promising targets surface; these neurons were connected King’s College London, UK Independent Investigator to modify in the brain and body in order to with the amygdala, part of the brain in- Young Investigator Grant–Basic Research Uwe Rudolph, M.D. Grant–Basic Research alter eating behavior. volved in emotion and behavior. They were McLean Hospital/Harvard Medical School able to alter feeding behavior simply by Distinguished Investigator Grant– Roland Zahn, M.D., Ph.D. One grantee found that an enzyme called manipulating axons in the amygdala, thus Basic Research Institute of Psychiatry/King’s College OGT is a critical regulator of the brain’s suggesting new targets for future thera- London, United Kingdom hunger circuits. Another grantee discov- peutic interventions. Julia Sacher, M.D., Ph.D. Independent Investigator Grant–Next ered that neural circuits controlling hunger Max-Planck Institute for Brain Research, Generation Therapies Germany Young Investigator Grant–Basic Research

48 ANNUAL REPORT 2016 www.bbrfoundation.org 49 m e n t a l i l l n e s s –

Foundation grantees have identified ders to re-develop as neurons, making pos- Silvia Bernardi, M.D. shared susceptibility genes in bipolar dis- sible a wide variety of previously impossible Columbia University order and schizophrenia, while other have experiments in autism, schizophrenia and Young Investigator Grant–Basic Research g e n e r a l / found genetic abnormalities shared across other illnesses. five disorders (schizophrenia, bipolar disor- Erin Nicole Bobeck, Ph.D. der, autism, major depression and ADHD). A recent grantee used carbon dating to find Icahn School of Medicine at Mount Sinai the “birthdates” of cells in the brain’s hip- Young Investigator Grant–Basic Research These genomic studies have identified pocampus, in turn revealing the strength of risk variants for psychiatric disorders and neurogenesis, or the birth of new neurons, Linda Booij, Ph.D. m u l t i p l e broadly indicate that genetic risk does not throughout life – an important enabler of Concordia University, Canada obey diagnostic boundaries, with many risk neural plasticity and a factor in resilience Independent Investigator Grant– variants instead increasing susceptibility that is an important factor in recovery Basic Research across a range of disorders. Pathways of across disorders. risk are beginning to emerge from these Erin S. Calipari, Ph.D. genomic findings. Bénédicte Amilhon, Ph.D. Icahn School of Medicine at Mount Sinai d i s o r d e r s Douglas Mental Health University Institute, Young Investigator Grant–Basic Research A grantee made the breakthrough inven- McGill University, Canada tion of optogenetics, a technology that Young Investigator Grant–Basic Research Donna J. Calu, Ph.D. revolutionized neuroscience and brain University of Maryland School of Medicine research across all illnesses, making it Jason Aoto, Ph.D. Young Investigator Grant–Basic Research possible to switch neurons on and off us- University of Colorado, Denver ing beams of colored laser light. A grantee Young Investigator Grant–Basic Research Bo Cao, Ph.D. pioneered the study of how epigenetic University of Texas Health Science changes–chemical tags that attach to Raymundo Baez-Mendoza, Ph.D. Center at Houston genes, affecting how they are regulated Massachusetts General Hospital Young Investigator Grant–Basic Research – are implicated across the genome in and Harvard University different mental illnesses. Young Investigator Grant–Basic Research Alexandre Charlet, Ph.D. Centre National de la Recherche A grantee helped confirm the link be- Rita Baldi, Ph.D. Scientifique(CNRS), University Pierre & tween elevated inflammation levels due to Vanderbilt University Marie Curie, France early-life stress and subsequent develop- Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research ment of a range of mental illnesses, often post-puberty. Grantees have discovered Tahsin Stefan Barakat, M.D., Ph.D. Jerry Lu Chen, Ph.D. circuitry responsible in depression and University of Edinburgh, UK Boston University schizophrenia for the inability of patients Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research to experience pleasure (anhedonia). Tracy Bedrosian, Ph.D. Paula Louise Croxson, Ph.D. Grantees have re-programmed skin cells Salk Institute for Biological Studies Icahn School of Medicine, Mount Sinai sampled from patients with various disor- Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research

50 ANNUAL REPORT 2016 www.bbrfoundation.org 51 Joseph D. Dougherty, Ph.D. Richard Scott Jope, Ph.D. Ian Mendez, Ph.D. Washington University School of Medicine University of Miami University of California, Los Angeles Independent Investigator Grant – Basic Distinguished Investigator Grant– Young Investigator Grant–Basic Research Research Next Generation Therapies Anna Victoria Rotberg Molofsky, Alexis Edwards, Ph.D. Arie Kaffman, M.D., Ph.D. M.D., Ph.D. Virginia Commonwealth University Yale University University of California, San Francisco Young Investigator Grant–Basic Research Independent Investigator Grant– Young Investigator Grant–Basic Research Nadine Provencal, Ph.D. Ludovic Tricoire, Ph.D. Romy Wichmann, Ph.D. Basic Research Max-Planck Institute for Psychiatry, Germany Centre National de la Recherche Massachusetts Institute of Technology Evan Feinberg, Ph.D. Sara Morrison, Ph.D. Young Investigator Grant–Basic Research Scientifique (CNRS), University Pierre & Young Investigator Grant–Basic Research University of California, San Francisco Roselinde Henderson Kaiser, Ph.D. University of Pittsburgh Marie Curie, France Young Investigator Grant–Basic Research Harvard Medical School Young Investigator Grant–Basic Research Steve Ramirez, Ph.D. Young Investigator Grant–Basic Research Kai Xia, Ph.D. Young Investigator Grant–Basic Research Harvard University University of North Carolina, Chapel Hill Ozgun Gokce, Ph.D. Anirvan Nandy, Ph.D. Young Investigator Grant–Basic Research Gustavo X. Turecki, M.D., Ph.D. Young Investigator Grant–Basic Research Ludwig-Maximilians University, Germany Seung Suk Kang, Ph.D. Salk Institute for Biological Studies McGill University, Canada Young Investigator Grant–Basic Research University of Minnesota Young Investigator Grant–Basic Research Danielle Roubinov, Ph.D. Distinguished Investigator Grant– Mingshan Xue, Ph.D. Young Investigator Grant–Basic Research University of California, San Francisco Basic Research Baylor College of Medicine Sarah A. O. Gray, Ph.D. Pieter Naude, Ph.D. Young Investigator Grant – Basic Research Young Investigator Grant–Basic Research Tulane University Caitlin Kantrowitz Rollins, M.D. University of Cape Town, South Africa Stacy Tzoumakis, Ph.D. Young Investigator Grant–Basic Research Children’s Hospital, Boston Young Investigator Grant–Basic Research Esther Serrano Saiz, Ph.D. University of New South Wales, Australia Guang Yang, Ph.D. Young Investigator Grant–Basic Research Columbia University Young Investigator Grant– The Hospital for Sick Children, Brad Alan Grueter, Ph.D. William Paul Nobis, M.D., Ph.D. Young Investigator Grant–Basic Research Diagnostic Tools/Early Intervention University of Toronto, Canada Vanderbilt University Medical Center Il Hwan Kim, Ph.D. Northwestern University Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research Duke University Medical Center Young Investigator Grant–Basic Research Dongju Seo, Ph.D. Rudolf Uher, M.D., Ph.D. Young Investigator Grant–Basic Research Yale University School of Medicine Dalhousie University, Canada Gwyneth Zai, M.D., Ph.D. Casey Harrison Halpern, M.D. Ashley Elizabeth Nordsletten, Ph.D. Young Investigator Grant–Basic Research Independent Investigator Grant– University of Toronto, Canada Stanford University Kwang-Soo Kim, Ph.D. Karolinska Institute, Sweden Basic Research Young Investigator Grant–Basic Research Young Investigator Grant– McLean Hospital/Harvard Medical School Young Investigator Grant–Basic Research Stephen Vincent Shepherd, Ph.D. New Technologies Distinguished Investigator Grant– The Rockefeller University Mirjam Van Zuiden, Ph.D. Alyson Kay Zalta, Ph.D. Basic Research Elizabeth A. Olson, Ph.D. Young Investigator Grant–Basic Research University of Amsterdam, Netherlands Rush University Medical College Kyung-An Han, Ph.D. McLean Hospital and Harvard University Young Investigator Grant– Young Investigator Grant–Diagnostic Tools/ University of Texas at El Paso Daniel Allen Lee, Ph.D. Young Investigator Grant–Basic Research Gleb P. Shumyatsky, Ph.D. Basic Research Early Intervention Independent Investigator Grant– California Institute of Technology Rutgers University Basic Research Young Investigator Grant–Basic Research Angela Macia Ortega, Ph.D. Independent Investigator Grant–Basic Neide Vieira, Ph.D. Tim Ziermans, Ph.D. University of California, San Diego Research University of Minho, Portugal Leiden University, Netherlands Jakob Hartmann, Ph.D. Marian Lee Logrip, Ph.D. Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research Harvard University and McLean Hospital Indiana University Gek Ming Sia, Ph.D. Young Investigator Grant–New Young Investigator Grant–Basic Research Ina P. Pavlova, Ph.D. University of Texas Health Science Center Cheng Wang, M.D., Ph.D. Larry S. Zweifel, Ph.D. Technologies Research Foundation for Mental Hygiene, Inc./ at San Antonio University of California, San Francisco University of Washington Andres V. Maricq, M.d., Ph.D. NYSPI at Columbia University Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research Independent Investigator Grant– Weizhe Hong, Ph.D. University of Utah Young Investigator Grant–Basic Research Basic Research University of California, Los Angeles Distinguished Investigator Grant– Aline Silva De Miranda, Ph.D. Minghui Wang, Ph.D. Young Investigator Grant–Basic Research Basic Research Hyun-Jae Pi, Ph.D. Federal University of Minas Gerais, Brazil Cold Spring Harbor Laboratory Cold Spring Harbor Laboratory Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research Mihaela D. Iordanova, Ph.D. Colleen Ann Mcclung, Ph.D. Young Investigator Grant–Basic Research Concordia University University of Pittsburgh Philip Tovote, Ph.D. Simon Keith Warfield, Ph.D. Young Investigator Grant–Basic Research Independent Investigator Grant– Marina R. Picciotto, Ph.D. Friedrich Miescher Institute, Switzerland Children’s Hospital, Boston Basic Research Yale University Young Investigator Grant–Basic Research Distinguished Investigator Grant– Lisanne Michelle Jenkins, Ph.D. Distinguished Investigator New Technologies University of Illinois at Chicago Nikolaos Mellios, M.d., Ph.D. Grant–Basic Research Young Investigator Grant– University of New Mexico Diagnostic Tools/Early Intervention Young Investigator Grant–Basic Research

52 ANNUAL REPORT 2016 www.bbrfoundation.org 53 p o s t – t r a u m a t i c o b s e s s i v e s t r e s s d i s o r d e r c o m p u l s i v e ( p t s d ) Among the symptoms experienced by asone showed that its administration Daniela Kaufer, Ph.D. people who develop PTSD is “anxious prior to a traumatic event enabled mice University of California, Berkeley arousal”–feeling tense or easily startled. to cope with stress and keep related fear Independent Investigator Grant–New Foundation grantees were part of a team extinguished 24 hours later–a normal fear Technologies d i s o r d e r that links these symptoms to a reduction in response–suggesting a path toward novel the size of the amygdala, a brain structure therapeutics. Although it is counterintui- Benjamin Kelmendi, M.D. Recently, BBRF grantees discovered a It was possible to halt the behavior with an associated with fear processing and tive, evidence suggests that by elevating Yale University network of related proteins that functions antidepressant, suggesting it may be possi- emotion. In combat vets with the most the levels of stress hormone it might be Young Investigator Grant–Next specifically in the striatum, a brain area that ble to stop abnormal circuit changes before severe anxious arousal symptoms, the able to reduce PTSD symptoms, on the Generation Therapies controls voluntary movements, especially they become pathological in people at risk right amygdala was smaller than in other theory that stress hormones may have for rewards. They showed that the proteins for OCD. Though medication is often pre- people; it was smallest in vets who had protective effects that prevent accompany- Justin Michael Moscarello, Ph.D. form a pathway that suppresses excessive scribed for OCD, up to half of patients do seen the most severe combat. ing changes in synaptic connectivity. New York University grooming in mice, offering molecular in- not respond, including those who are most Young Investigator Grant–Basic Research sights into the mechanisms that may con- seriously impaired. Working as a pacemaker A great deal of research by grantees Other research has tested a drug called trol repetitive behaviors in people as well. for the brain, deep brain stimulation (DBS), has revealed circuitry in the brain that osanetant to alleviate PTSD symptoms Isabelle Rosso, Ph.D. In other recent work, grantees confirmed pioneered by a grantee, is now being used is involved in fear reactions; it is hoped before they become disabling; and novel Harvard University evidence of white matter alterations in as an alternative treatment. these will present targets for future ther- drugs against so-called DREADD receptors– Independent Investigator Grant–Next adults with OCD, and gave a more complete apeutic interventions. Grantees recently artificial docking ports on cells designed to Generation Therapies picture of where those alterations lie. Stephanie Dulawa, Ph.D. found that both active and passive fear engage with potent medicines–in order to University of California-San Diego responses are controlled in the central impair the formation of fear memories. Christine A. Rabinak, Ph.D. This research suggests that large-scale Independent Investigator Grant– amygdala, with distinct types of neurons Wayne State University brain networks may be disrupted in the Basic Research involved in each reaction. Kelly Patricia Cosgrove, Ph.D. Young Investigator Grant–Basic Research disorder, possibly affecting information Yale University flow between regions of the brain involved Daigo Homma, Ph.D. Other new research identifies molecu- Independent Investigator Grant–Basic Stephanie Trouche, Ph.D. in learning and cognition, spatial working Massachusetts Institute of Technology lar mechanisms that promote memory Research University of Oxford, UK memory and attention, as well as areas Young Investigator Grant–Basic Research strengthening and at the same time Young Investigator Grant–Basic Research more involved with motor control. prevent memories from fading. This Rosalina Fonseca, M.D., Ph.D. Minseok Song, Ph.D. work helps explain how some memories Gulbenkian Institute of Science, Portugal Rachel Yehuda, Ph.D. Using optogenetics to switch neurons Weill Cornell Medical College get stronger over time even in the Young Investigator Grant–Basic Research Icahn School of Medicine at Mount Sinai off and on with beams of light, grantees Young Investigator Grant–Basic Research absence of threatening experiences. Distinguished Investigator Grant– showed that repeated stimulation of neural How to extinguish fear memories is Chuan Huang, Ph.D. Diagnostic Tools/Early Intervention circuits linking the cortex and striatum the subject of considerable attention. Stony Brook University School of Medicine produced progressive repetitive behavior Young Investigator Grant– that continued for up to two weeks after One grantee has pioneered various poten- Next Generation Therapies the stimulation ended. tial drug interventions to this end. Testing with the corticosteroid drug dexameth-

54 ANNUAL REPORT 2016 www.bbrfoundation.org 55 Wing Chung Chang, Fhkcpsych Jee-Yeon Hwang, Ph.D. Toral S. Surti, M.D., Ph.D. Chinese University of Hong Kong Albert Einstein College of Medicine Yale University Young Investigator Grant– Young Investigator Grant–Basic Research Young Investigator Grant–Basic Research Next Generation Therapies Jason Karl Johannesen, Ph.D. Neal R. Swerdlow, M.D., Ph.D. Eric Hau-Yun Chang, Ph.D. Yale University University of California, San Diego Feinstein Institute for Medical Research Young Investigator Grant–Basic Research Distinguished Investigator Grant–Next Young Investigator Grant– Generation Therapies New Technologies Esther Soon Kim, Ph.D. schizophrenia Columbia University Ai-Hui Tang, Ph.D. Kayla A. Chase, Ph.D. Young Investigator Grant–Basic Research University of Maryland School of Medicine University of California, San Diego Young Investigator Grant–Basic Research Research by Foundation grantees has revealed a great deal by two grantees has found that cognitive problems experienced Young Investigator Grant–Basic Research Ethan Lippmann, Ph.D. about schizophrenia’s complex genetic underpinnings, recently by people with schizophrenia, such as problems with attention Vanderbilt University Laura Magdalen Tully, Ph.D. identifying 108 locations in the human genome where common and memory, are present in the early stage of the disorder, before Youngsun Theresa Cho, M.D., Ph.D. Young Investigator Grant– University of California Davis Medical Center gene variations have an impact on risk. Grantees have discovered the onset of psychosis. Yale University New Technologies Young Investigator Grant–Next Generation the importance of large-scale gene copy-number variations in Young Investigator Grant–Basic Research Therapies causing schizophrenia. Assessing cognitive function early therefore could help clinicians Brian James Miller, M.D., Ph.D., M.P.H. identify people who are most likely to develop the disorder. Other Timothy Hanks, Ph.D. Georgia Regents University Remko Van Lutterveld, Ph.D. Grantees have also changed the way schizophrenia treated in research by grantees have established that the age of the father University of California, Davis Independent Investigator Grant– University of Massachusetts Medical School most patients, and their basic and clinical research is leading to at time of conception is an important factor in child’s schizophre- Young Investigator Grant–Basic Research Next Generation Therapies Young Investigator Grant–Next insights that will create the treatments of tomorrow, focusing nia risk; discovered the role of MHC proteins (vital in the immune Generation Therapies especially on effective ways to reduce cognitive symptoms. system) in causing overpruning of neural synapses in the prefron- Beng-Choon Ho, M.D. Vishnu P. Murty, Ph.D. tal cortex, early in life, a possible contributor to schizophrenia University of Iowa University of Pittsburgh Dawn I. Velligan, Ph.D. A Scientific Council Member was instrumental in developing in some patients; and discovered that estrogen, which protects Distinguished Investigator Grant– Young Investigator Grant–Basic Research University of Texas Health and validating the effectiveness of 2nd-generation (“atypical”) nerve cells in the brain, can improve cognition in some patients. Diagnostic Tools/Early Intervention Science Center at San Antonio antipsychotic medicines. Dhakshin Ramanathan, M.D., Ph.D. Distinguished Investigator Grant– Atheir Ibrahim Abbas, M.D., Ph.D. Christian Bauer Hoss, M.D., Ph.D. University of California, San Francisco Basic Research Another Scientific Council pioneered the use of cognitive behavior- New York State Psychiatric Institute of Columbia University Massachusetts Institute of Technology Young Investigator Grant–Basic Research al therapy (CBT), including its use in treating “negative” symptoms Young Investigator Grant–Basic Research Young Investigator Grant–Next Generation Thomas Weickert, Ph.D. such as emotional flatness, lack of motivation, and social isolation. Therapies Marta Rapado-Castro, Ph.D. University of New South Wales, Australia Stewart Alan Anderson, M.D. CIBERSAM- Centro de Investigación en Independent Investigator Grant– Experiments by grantees with transcranial direct current stimu- Children’s Hospital of Philadelphia, University of Pennsylvania Britta Galling, M.D. Red de Salud Mental, Spain Next Generation Therapies lation (tDCS) brought brain wave anomalies into synchrony and Independent Investigator Grant–Basic Research Feinstein Institute for Medical Research Independent Investigator Grant– improved cognitive symptoms in patients. Young Investigator Grant–Next Next Generation Therapies Mathieu Wolff, Ph.D. Andrew Wayne Bismark, Ph.D. Generation Therapies Universite Bordeaux II, France Grantees are working on alternative medications to antipsychotics, VA San Diego Healthcare System at the University Rafael Penades, Ph.D. Independent Investigator Grant– for instance small molecule drugs that influence the beta-arrestin of California, San Diego Tonya Marie Gilbert, Ph.D. University of Barcelona (Universitat Basic Research communication pathway, which in mouse models reduced hyperac- Young Investigator Grant–Next Generation Therapies Massachusetts General Hospital- de Barcelona), Spain tive movements, improved memory for novel stimuli and resulted Harvard University Independent Investigator Grant–Next Todd Woodward, Ph.D. in more social behavior. A grantee discovered that treatments with Marta Busnelli, Ph.D. Young Investigator Grant–New Generation Therapies University of British Columbia, Canada D-serine, an activator of the NMDA receptor, can reverse schizo- Institute of Neuroscience of the National Research Council Technologies Independent Investigator Grant– phrenia-like cognitive symptoms in mice. To prevent schizophrenia Young Investigator Grant–Basic Research Tade Souaiaia, Ph.D. Next Generation Therapies pathology in the earliest stages of life, grantees are investigating Elliot Hong, M.D. University of Southern California how to prevent these brain abnormalities from ever forming. Kristen Jennifer Brennand, Ph.D. Maryland Psychiatric Research Center Young Investigator Grant–Basic Research John-Paul J. Yu, M.D., Ph.D. Icahn School of Medicine at Mount Sinai Distinguished Investigator Grant– University of Wisconsin One approach now being tested involves giving expectant moth- Independent Investigator Grant–Basic Research Basic Research Emma Sprooten, Ph.D. Young Investigator Grant–New ers choline supplements from the prenatal period to assure prop- Icahn School of Medicine at Mount Sinai Technologies er fetal brain development. In the clinic, an authoritative study led Laurence Tudor Hunt, Ph.D. Young Investigator Grant–New University of London, UK Technologies Young Investigator Grant–Basic Research

56 ANNUAL REPORT 2016 www.bbrfoundation.org 57 o t h e r s u i c i d e d i s o r d e r s FRAGILE X SYNDROME Manavi Chatterjee, Ph.D. Maria Soledad Esposito, Ph.D. Yale University Friedrich Miescher Institute, Switzerland Young Investigator Grant–Next Genera- Young Investigator Grant–Basic Research r e s e a r c h / tion Therapies p r e v e n t i o n p s y c h o s i s

BBRF grantees have helped to shape what having suicidal thoughts or has made a Recent research by grantees has con- resilience and self-management skills, David Reid Roalf, Ph.D. we know about why certain people, and suicide attempt. Important research led by firmed that young people with mild family psychoeducation and support, and University of Pennsylvania in particular young people, have suicidal a grantee has revealed that the history of but clinically relevant symptoms are at supported education and employment Young Investigator Grant–New thoughts and sometimes act on them. parents’ suicide attempts predicts suicidal increased risk for developing a psychotic opportunities. Data from 600 patients was Technologies behavior in their children. Prediction is one disorder. Initial clinical trials suggest that used by a grantee to develop a new risk A Scientific Council Member and Grantee of the ultimate goals of research--the abili- treatment can reduce symptoms and calculator that helps identify the one per- Daniel Scott, Ph.D. led research establishing that most teen ty not only to identify those at highest risk progression to full psychosis. son in three at high-risk of psychosis who University of Texas Southwestern suicides occur in people with diagnosable of thinking suicidally or even attempting is likely to go on to develop full psychosis Medical Center at Dallas mental illnesses. suicide but in fact completing the act. A dozen grantees were involved in the within 3 years. Young Investigator Grant–Basic Research North American Prodrome Longitudinal Another Scientific Council Member created A grantee has developed two clinical Study, an international effort to identify Another study, involving 8 grantees, sug- Stefania Tognin, Ph.D. the TeenScreen, the tool used nationwide questionnaires in the form of apps for factors that contribute to the develop- gests that frequent in-person check-ins Institute of Psychiatry and globally as a standard diagnostic and prediction in men, instruments that other ment of psychosis. They have demonstrat- may help lower relapses in schizophre- King’s College London, UK screening tool. grantees have now tested and validated for ed that a panel of blood markers could be nia-related psychosis. Young Investigator Grant–Basic Research use in women. In the meantime, the search used to identify those who are showing Grantees involved in clinical research have continues, in the labs of many grantees, for mild prodromal symptoms and are at A grantee’s 7-year study in people with conducted extensive testing of ketamine genetic clues and markers in the human highest risk of developing psychosis. early psychosis symptoms showed the and ketamine substitutes in a variety of body that can provide insights and predic- possible effectiveness of PUFA (omega-3) clinical settings to treat people who have tive clues to this most agonizing and tragic Grantees played a lead role in a landmark supplements in preventing progression just attempted suicide or are thought likely of human behaviors. study demonstrating that early and coor- to full psychosis, perhaps by reducing to be at high risk for making an attempt. dinated team care after a first psychotic inflammation in the brain and spurring Jeremy Gordon Stewart, Ph.D. episode can make a positive difference in the growth of new neurons. A grantee is Grantees involved in basic research have McLean Hospital and Harvard University outcome. Best practices identified in the testing scalp electroencephalogram (EEG) discovered markers that can be seen Young Investigator Grant–Diagnostic Tools/ study included first-episode intervention data to detect “mismatch negativity” and in routine blood tests that predict with Early Intervention using low-dose antipsychotic medications, thus predict onset of psychosis in high- 80%-96% accuracy whether a person is cognitive behavioral therapy to support risk individuals.

58 ANNUAL REPORT 2016 www.bbrfoundation.org 59 International Awards Dinner 2 0 1 6 New York, October 28, 2016 The Foundation celebrated its 29th Annual International Awards Dinner at The Pierre Hotel in New York City. The evening’s honor- MALTZ PRIZE FOR INNOVATIVE & PROMISING ees included two remarkable humanitarians, one of the world’s SCHIZOPHRENIA RESEARCH most prominent mental health advocates and nine exceptional William P. Horan, Ph.D. scientists for their significant contributions to the advancement Amanda McCleery, Ph.D. f o u n d a t i o n of our understanding of schizophrenia, mood disorders, child and adolescent psychiatry and cognitive neuroscience. PARDES HUMANITARIAN PRIZE IN MENTAL HEALTH This international Prize recognizes a physician, scientist, public OUTSTANDING ACHIEVEMENT AWARDS citizen, or organization whose extraordinary contribution has made a profound and lasting impact by improving the lives LIEBER PRIZE FOR SCHIZOPHRENIA RESEARCH of people suffering from mental illness and by advancing the e v e n t s Michael F. Green, Ph.D. understanding of mental health. Stephen R. Marder, M.D. HONOREES COLVIN PRIZE FOR MOOD DISORDERS RESEARCH Vikram Patel, Ph.D., F.Med.Sci. Francis J. McMahon, M.D. Charles F. Reynolds III, M.D. Thomas G. Schulze, M.D. Pamela Sklar, M.D., Ph.D. HONORARY TRIBUTE Senator Edward M. Kennedy RUANE PRIZE FOR CHILD & ADOLESCENT PSYCHIATRIC RESEARCH John L. R. Rubenstein, M.D., Ph.D.

GOLDMAN-RAKIC PRIZE FOR OUTSTANDING ACHIEVEMENT IN COGNITIVE NEUROSCIENCE Earl K. Miller, Ph.D.

Dr. Jeffrey Borenstein, Dr. Vikram Patel, Dr. Herbert Pardes, Dr. Charles Reynolds and Patrick Kennedy, Pardes Humanitarian Prize and Honorary Prizewinners

Dr. Eric and Dr. Denise Kandel Lieber & Maltz Prizewinners–Dr. William Horan, Dr. Amanda McCleery, Dr. Michael Green and Dr. Stephen Marder of UCLA

60 ANNUAL REPORT 2016 www.bbrfoundation.org 61 Klerman & Freedman Awards Dinner New York, July 29, 2016

This very special evening celebrated the extraordinary life of a HONORABLE MENTIONS global champion of psychiatric research - Constance E. Lieber. Erin C. Dunn, Sc.D., M.P.H., of Harvard Medical School and Massa- Connie, along with her husband Steve, saw the need to nurture chusetts General Hospital for her grant research project “Sensitive and encourage young scientists. For this reason, it was especially Periods Associated with the Development of Depression.” appropriate to also honor the hallmark program of the Brain & Be- havior Research Foundation, the Young Investigator Grants, which Avram J. Holmes, Ph.D. of Yale University for his work in enable aspiring young scientists with innovative ideas to garner “Identifying the Network-Level Fingerprints of Affective Illness pilot data and generate “proof of concept” for their work. and Associated Polygenic Vulnerability in the General Population.”

Six Young Investigator Grantees were honored for their outstand- FREEDMAN PRIZEWINNER ing contributions to mental health research at The Metropolitan Kay M. Tye, Ph.D., of the Massachusetts Institute of Technology Club in New York City. These researchers were chosen by a com- for her work on “Identifying Unique Neural Circuits for Anxiety mittee of the Foundation’s Scientific Council for their exceptional Control.” grant projects in terms of insight and potential new approaches to 6 the treatment of mental illness. HONORABLE MENTIONS Kathleen Kyung Ah Cho, Ph.D., of the University of California, Each investigator has demonstrated exceptional promise in the San Francisco for her grant project titled “Investigation of Interneu- pursuit of deeper understanding of the human brain to ultimately ron and Circuit Dysfunction in a Mouse Model of Schizophrenia,” result in cures through research. Conor Liston, M.D., Ph.D., of Weill Cornell Medical College for his KLERMAN PRIZEWINNER grant project, “Stress Effects on Connectivity in Developing Fronto- Katie A. McLaughlin, Ph.D. of the University of Washington for striatal Circuits,” her work on “Child Maltreatment and Neural Networks Underlying Emotion Regulation: A Neurodevelopmental Pathway to Anxiety and Depression.”

5 7

1 2

8 9

1 Dr. Jeffrey Borenstein honoring Connie Lieber 2 Dr. Avram Holmes and Dr. Herbert Pardes 3 Dr. Kay Tye and Dr. Herbert Pardes 4 Dr. Connor Liston and Dr. Herbert Pardes 5 Stephen Lieber & Miriam Katowitz, Dr. Joshua Gordon, Dr. James Frauenthal and Dr. Myrna Weissman 6 Barbara Toll, Ursula von Rydingsvard, Dr. Paul Greengard and Dr. Eric Kandel 7 Dr. Kathleen Cho and Dr. Herbert Pardes 8 Dr. Katie McLaughlin and Dr. Herbert Pardes 9 Dr. Erin Dunn and Dr. Herbert Pardes 3 4

62 ANNUAL REPORT 2016 www.bbrfoundation.org 63 Symposium Commentator Dr. Alan Schatzberg Dr. Michael Green Dr. Stephen Marder

Dr. Amanda McCleery & Dr. William Horan Dr. Thomas Schulze Dr. Pamela Sklar

Keynote Presenter Robert Boorstin

International Mental Health Research Symposium New York, October 28, 2016

The 28th Annual New York Mental Health IMPROVING FUNCTIONING IN PEOPLE WITH USING GENOMICS TO CHANGE OUR UNDER- Research Symposium featured a keynote PSYCHOTIC ILLNESS: A NEW GOAL FOR STANDING OF MENTAL ILLNESS presentation and scientific presentations TREATMENT RESEARCH Pamela Sklar, M.D., Ph.D. by the nine 2016 Outstanding Achievement Stephen R. Marder, M.D. Dr. Francis McMahon Dr. Earl Miller Dr. John Rubenstein Prizewinners and two exceptionally prom- COGNITION IS RHYTHMIC ising Young Investigator Grantees and was DEVELOPING INTERVENTIONS TO ENHANCE Earl K. Miller, Ph.D. held at The Kaufman Music Center in New SOCIAL COGNITION IN SCHIZOPHRENIA York City. William P. Horan, Ph.D. GENETIC ANALYSES OF FOREBRAIN DEVEL- OPMENT GIVE INSIGHTS INTO ORIGINS OF KEYNOTE SPEAKER: A SEARCH FOR EXPLORING THE PHENOTYPIC COMPLEXITY NEUROPSYCHIATRIC DISORDERS BALANCE: PERSONAL & POLITICAL IN PSYCHIATRIC GENETICS: FROM John L. R. Rubenstein, M.D., Ph.D. REFLECTIONS ON MENTAL HEALTH PHARMACORESPONSE TO ILLNESS Robert O. Boorstin TRAJECTORIES ARE SOME MILITARY PERSONNEL Thomas G. Schulze, M.D. DIAGNOSED WITH PTSD ACTUALLY SEEING, FEELING, AND INFERRING THE SUFFERING FROM CHRONIC TRAUMATIC SOCIAL WORLD IN SCHIZOPHRENIA SEEING THE WORLD IN A GRAIN OF SAND: ENCEPHALOPATHY? Michael F. Green, Ph.D. MAKING SENSE OF THE MANY GENES THAT Tracy Butler, M.D. UNDERLIE BIPOLAR DISORDER NEUROPLASTICITY IN SCHIZOPHRENIA: Francis J. McMahon, M.D. NONINVASIVE NEUROMODULATION Dr. Tracy Butler Dr. Timothy Mariano Symposium Moderator Dr. Robert HOW TO MEASURE IT, AND WHAT DOES FOR CHRONIC PAIN Hirschfeld & Dr. Jeffrey Borenstein IT MEAN? Timothy Mariano, M.D., Ph.D., MSc. Amanda McCleery, Ph.D.

64 ANNUAL REPORT 2016 www.bbrfoundation.org 65 CARING FOR A CHILD WITH response, he and his colleagues developed BIPOLAR DISORDER the MDQ—the Mood Disorder Question- Robert M.A. Hirschfeld, M.D. naire. The 13-question test is available at p a r e n t i n g Professor of Clinical Psychiatry many doctors’ office, advocacy organiza- Weill Cornell Medical College tions, and online at sites such as www.dbsalliance.org/pdfs/MDQ.pdf. For the families of young people diagnosed with psychiatric • Scientific Council Member • 2003 Falcone Prize for Outstanding It asks “…things about whether you’ve ever disorders, it can be frightening, bewildering, and frustrating. Achievement in Affective Disorders had times when you spent too much mon- Research ey, times when you had an abnormally high Where do they turn for help? • 2002 Distinguished Investigator Award mood—it goes through a number of the symptoms of mania, and it takes about five Bipolar illness was once referred to as minutes to fill out,” Dr. Hirschfeld explained. “manic-depressive” illness, and is consid- The Foundation’s magazine now includes information that can ered to be a lifelong disorder, said Robert He stressed that the MDQ is a screening M.A. Hirschfeld, M.D., a professor of clinical tool, and that a mental healthcare provider be of practical use to families coping with the diagnosis of a psychiatry at Weill Cornell Medical College. can help with a more comprehensive eval- The disorder is characterized by episodes uation. In a study that Dr. Hirschfeld con- behavioral disorder or mental illness. These articles can be of abnormal, often persistent, highs and ducted with his colleagues, they found that abnormal, often persistent lows. But the the MDQ can help clarify a bipolar disorder found at bbrfoundation.org/parenting. latest edition of the DSM-5, the manual diagnosis especially in cases where parents that doctors use to diagnose psychiatric and children disagree on symptoms. disorders, has made a major change in that it also considers a change in energy, as well Many adolescents with bipolar disorder as mood, to be essential to the disorder, lack insight about their condition—for Dr. Hirschfeld said. example, having no self-awareness of their manic episodes, said Dr. Hirschfeld. It may “We’ve always seen this as part of the take several manic episodes “having devas- illness. But now it’s understood as a tating consequences” to family, career, and necessary part,” he noted. “If you simply education before they recognize that they have the mood disturbance and no change have a lifelong illness, he said. “They will in energy, you do not get a diagnosis of deny, deny, deny—and it’s very sad. I often bipolar disorder.” see people in their 30s who are finally coming to terms with it and they have lost Dr. Hirschfeld said adolescents and their a decade of their life to the illness.” parents often have difficulties identifying bipolar disorder, or separating that from a diagnosis of major depression. In

66 ANNUAL REPORT 2016 www.bbrfoundation.org 67 ENHANCING EARLY CHILDHOOD important thing I would say to a parent that can help with this include Circle of Se- TYPICAL TEEN BEHAVIOR— any weapons in the house and make sure DEVELOPMENT with mental health issues is to help your- curity, Triple P the Power of Positive Parent- OR SOMETHING ELSE? Bipolar disorder in younger children, ages alcohol or prescription medication are not James F. Leckman, M.D., Ph.D. self deal with those issues. Reach out to a ing, and Parenting Management Training. David Miklowitz, Ph.D. four to six, is not very common. But Dr. easily available,” said Dr. Miklowitz. Neison Harris Professor of Child Psychiatry, mental health professional—find someone Professor, Division of Child and Miklowitz said that young children with the Psychiatry, Pediatrics and Psychology who is really invested in addressing the A special ingredient in fostering resilience Adolescent Psychiatry disorder may have problems with sleep, Therapy for the parents, child, and some- Yale University problem,” he said. in children “is an understanding adult who UCLA Semel Institute increased activity, impulsiveness, and times siblings as well can be helpful for in some way sees in you something special, occasional signs of delusional thinking. bipolar disorder. This family-focused • 2011 Colvin Prizewinner for Outstand- Intervening early in a child’s development Dr. Leckman said that childhood exposure in some way idealizes you and sees you as ing Achievement in Mood Disorder “When we have a child who shows those treatment, said Dr. Miklowitz, could include has many long-term benefits to both the to trauma or violence, even during the someone who is able to make a positive Research. signs, we often don’t know whether it’s psychoeducation, communication training, individual and society, said James F. Leck- prenatal period when the brain is develop- contribution,” Dr. Leckman emphasized. bipolar or some other disorder, or even a and problem-solving skills training. Chil- man, M.D., Ph.D., Neison Harris Professor ing, can mold how the brain is organized • 2001 Distinguished Investigator Award developmental transition. Mania is often dren with bipolar disorder may also benefit of Child Psychiatry, Psychiatry, Pediatrics, and have a major impact on how our genes • 1987 Young Investigator Award confused with attention deficit disorder, from having an individualized educational and Psychology at Yale University. At the are expressed. Brain imaging studies and both poles can have a significant program (IEP) at school. Dr. Miklowitz added level of the society, one of the biggest ben- also show that traumatized children have anxiety component,” he said. that children should play a role in the nego- efits is the savings on the costs associated different interconnections in their brain About 1.8 percent of children under age tiation of any medication and dosages, and with incarceration and with criminal be- regions than those who were not exposed 18 have some form of bipolar disorder, Dr. Miklowitz said determining whether a that both parents “should be on the same haviors, he said. “If you intervene early, the to violence. “If you’ve been exposed to although the majority of cases emerge be- teen’s unstable moods or risky behavior page” about medications, to ensure that the person has a greater likelihood of finishing violence,” he said, “you’re at an increased tween ages 15 and 19, said David Miklowitz, is an expression of bipolar disorder or child uses any medication properly. high school, of going to college, and is less risk of being re-victimized.” Ph.D., a professor of child and adolescent “typical teen behavior” can be “one of the likely to be involved in criminal behavior.” psychiatry at the UCLA Semel Institute. toughest problems for parents. But the key He encouraged people to think about how Adolescents differ from adults with the is the clustering of unstable moods with Dr. Leckman said there is a greater risk they were parented, especially if they are disorder in that they tend to have longer other symptoms,” he said. Watchful waiting of a child having a mental illness if his or having problems in their relationship with periods of “subthreshold” or less than full- may help parents decide whether medica- her parents also have a mental illness, their children. These parents may want to blown symptoms, more frequent switches tions or therapy are warranted, and keep- although it may be difficult to tell whether seek out programs to enhance and learn between depression and mania, and more ing a record of behaviors is also important. the parent’s behavior, or his or her genes, new positive parenting strategies. Some mixed episodes that combine mania and However, “if your child has expressed any or both may increase this risk. “The most family-based early intervention programs depression, he noted. suicidal ideation and depression, get rid of

68 ANNUAL REPORT 2016 www.bbrfoundation.org 69 a g l o b a l c h a m p i o n o f

Constance Lieber transformed her family’s experience with sig- enhance support of psychiatric research by awarding grants to psychiatric nificant metal illness into a life filled with meaning, purpose, and scientists in all kinds of disciplines—including biochemistry, phar- extraordinary helpfulness. She and her husband Steve shared an macology, genetics, psychology, and psychiatry. The main criterion enduring love for 70 years and the quest for intense intellectual for receiving a grant was quality. They wanted the best research. insights to transform the field of basic and clinical research in schizophrenia and other mental illnesses into the hope of finding Connie never stopped thinking about the next thing that could be cures through research. done to support the field and provide the help which will ultimate- r e s e a r c h ly lead to better understanding and treatments for psychiatric Connie, who served as President of the Brain & Behavior Re- illness. Guided by her compassion, dedication, and curiosity, Con- Constance Lieber search Foundation from 1989 to 2007, was a deeply caring and nie informally advised thousands of parents who were desperately visionary philanthropist, who has had a tremendous impact seeking help for their children. March 2, 1924–January 15, 2016 on psychiatric research and treatment. In her role as President Emerita, she continued to offer her vision and guidance to the We honor her passion, her aspirations, and her commitment to Foundation on a regular basis. She passionately believed in the help each and every one of us realize her seminal vision--to find need to seed the field of neuropsychiatric research with as many answers for the millions and millions of people around the world talented scientists as possible to make a substantive impact on who suffer from psychiatric illness. the broad spectrum of mental health research, which she fervently understood holds our best hope for ending the immense Connie was our leader and guiding light, providing inspiration and suffering caused by mental illness. motivation to all who ever had the honor and privilege of knowing and working with her. Numerous scientists and clinicians share a feeling of attachment to Connie that goes far beyond her philanthropic commitments, She will be dearly missed by us all, but her work continues and we because she became a part of their personal and profession- are all committed to making her dreams a reality. al lives. She and Steve transformed the private sector effort to “There is one person who is the prototype of generosity, brilliance, compassion and who is the essence of selflessness. I know her, you know her, and the world has come “Connie was our leader and guiding light, providing inspiration and “Connie was that rare breed of public advocate and philanthropist to know her . . . that is Connie Lieber.” motivation to all who ever had the honor and privilege of knowing whose interest and commitment actually shaped the course of and working with her.” progress in biomedical research. She was not someone sitting —Herbert Pardes, M.D. on the sidelines observing her philanthropy; she was an active President of the Scientific Council, —Jeffrey Borenstein, M.D. participant in the advance of scientific research about mental Brain & Behavior Research Foundation President & CEO illness.” Executive Vice Chairman of the Brain & Behavior Research Foundation Board of Trustees —Daniel Weinberger, M.D. NewYork-Presbyterian Hospital Director and Chief Executive Officer Lieber Institute for Brain Development

70 ANNUAL REPORT 2016 www.bbrfoundation.org 71 RESEARCH PARTNERS Our Research Partners Program enables donors to select and support a scientist’s project from amongst the most promising, cutting-edge proposals in mental illness research. Sponsoring one year of support for a Young Investigator is $35,000; an Independent Investigator, $50,000; and a Distinguished Investigator, $100,000.

JAN AND STEFAN ABRAMS Young Investigator Young Investigator Jan and Stefan Abrams Investigators Sjoerd Jehannes Finnema, Ph.D., Mira Alexandra Jakovcevski, Ph.D. Pharm.D. Max-Planck Institute of Psychiatry Young Investigator Yale University Max-Planck Society/Max Planck Institutes Marta Biagioli, Ph.D. d o n o r s University of Trento ATHERTON FOUNDATION SIDNEY R. BAER, JR. FOUNDATION Atherton Investigators Sidney R. Baer, Jr. Investigators Young Investigator We’re honored by the trust you, our donors have Yongsoo Kim, Ph.D. Young Investigator Independent Investigator Pennsylvania State University Lior Brimberg, Ph.D. Stephen J. Glatt, Ph.D. placed in the Brain & Behavior Research Foundation The Feinstein Institute for Medical Research State University of New York, ANNE AND RON ABRAMSON Upstate Medical University and the generous support you have provided to Abramson Family Foundation Investigator Young Investigator Peter Gregory Enticott, Ph.D. Young Investigator advance neuroscience. Young Investigator Monash University Mark Christian Eldaief, M.D. Sharmin Ghaznavi, M.D., Ph.D. Beth Israel Deaconess Medical Center Massachusetts General Hospital Young Investigator Harvard University Harvard University Brian J. O’Roak, Ph.D. Oregon Health and Science University Young Investigator ANONYMOUS Mei-Hua Hall, Ph.D. Haddie Investigators Young Investigator Harvard Medical School/ Harvard University Latha Soorya, Ph.D. Young Investigator Rush University Young Investigator Solange P. Brown, M.D., Ph.D. Eli Ayumi Stahl, Ph.D. Johns Hopkins University Young Investigator Icahn School of Medicine at Mount Sinai Kaustubh Satyendra Supekar, Ph.D. Young Investigator Stanford University Young Investigator Julie S. Haas, Ph.D. Gordaha D. Vitaliano, M.D. Lehigh University DIANA AND DAN ATTIAS McLean Hospital/ Harvard University Attias Family Foundation Investigators Young Investigator JANET AND DONALD BOARDMAN Theodoros Tsetsenis, Ph.D. Young Investigator Donald and Janet Boardman Investigator University of Pennsylvania Sebastien Delcasso, Ph.D. Massachusetts Institute of Technology Young Investigator ANONYMOUS Jessica A. Bernard, Ph.D. Young Investigator Texas A&M University Young Investigator Lauren Celia Faget, Ph.D. Desmond Jay Oathes, Ph.D. University of California, San Diego DAVID J. BREUER MEMORIAL University of Pennsylvania David J. Breuer Memorial Investigator Young Investigator ANONYMOUS Jennifer H. Foss-Feig, Ph.D. Young Investigator Connecticut Mental Health Center Viviane Labrie, Ph.D. Young Investigator Yale University Van Andel Research Institute Chadi Abdallah, M.D. Yale University Young Investigator Young Investigator Allyson Kimberly Friedman, Ph.D. Stephan Ripke, M.D., Ph.D. Young Investigator Research Foundation of The City University Charité–University Medicine Berlin Gianfilippo Coppola, Ph.D. of New York on behalf of Hunter College Freie Universitat Berlin Yale University

72 ANNUAL REPORT 2016 www.bbrfoundation.org 73 MR. AND MRS. EVERETT DESCHNER FAMILIES FOR BORDERLINE PERSONALITY HOFMANN TRUST CONSTANCE AND STEPHEN LIEBER Young Investigator Young Investigator Katherine Deschner Family Investigator DISORDER RESEARCH Hofmann Trust Investigator Lieber Investigators Antti S. Alaräisänen, M.D. Lingjun Zuo, M.D., Ph.D. Families For Borderline Personality University of Oulu Yale University Young Investigator Disorder Research Investigators Distinguished Investigator Distinguished Investigator Leah H. Somerville, Ph.D. Angelique Bordey, Ph.D. Claes Wahlestedt, M.D., Ph.D. Young Investigator EUNICE K. MEYER CHARITABLE Harvard University Young Investigator Yale University University of Miami Stefan Ehrlich, M.D. FOUNDATION Emily B. Ansell, Ph.D. Dresden University of Technology Eunice K. Meyer Charitable Foundation ESTATE OF OLGA V. TEDESCHI Syracuse University INTERNATIONAL BIPOLAR FOUNDATION Independent Investigator Investigators Olga V. Tedeschi Investigator International Bipolar Foundation Stanislav S. Zakharenko, M.D., Ph.D. Young Investigator Young Investigator Investigator St. Jude Children’s Research Hospital Herman B. Fernandes, Ph.D. Young Investigator Young Investigator D. Bradford Reich, M.D. Northwestern University Corinna Haenschel, Ph.D. Daniel John Foster, Ph.D. McLean Hospital/ Harvard University Young Investigator Young Investigator City University London Vanderbilt University Medical Center Rupali Srivastava, Ph.D. Edwin C. Oh, Ph.D. Young Investigator Young Investigator Johns Hopkins University Duke University George Foussias, M.D, M.Sc. Young Investigator ESSEL FOUNDATION Anthony Charles Ruocco, Ph.D. Centre for Addiction and Mental Health Tara A. Niendam, Ph.D. Essel Investigators Centre for Addiction and Mental Health THE RONA JAFFE FOUNDATION Young Investigator University of Toronto University of California, Davis University of Toronto The Rona Jaffe Foundation Investigator Krishnan Padmanabhan, Ph.D. Independent Investigator Salk Institute for Biological Studies Young Investigator NAMI MICHIGAN Julia A. Chester, Ph.D. Young Investigator Young Investigator Anna Francesconi, Ph.D. NAMI Michigan Investigator Purdue University Kate Eleanor Anne Saunders, June Gruber, Ph.D. Young Investigator Albert Einstein College of Medicine, Inc. B.M., B.Ch., M.A. University of Colorado, Boulder Marta Ribases, Ph.D. Young Investigator Independent Investigator University of Oxford Vall d’Hebron Research Institute VHIR Young Investigator Christine A. Rabinak, Ph.D. Wen-Jun Gao, M.D., Ph.D. KAPLEN FOUNDATION Karen J. Gregory, Ph.D. Wayne State University Drexel University College of Medicine Young Investigator Michael F. Kaplen Investigator Young Investigator Vanderbilt University Edward A. Selby, Ph.D. Jingchun Sun, Ph.D. NARSAD ARTWORKS Independent Investigator Rutgers University Young Investigator University of Texas Health Science Center Young Investigator NARSAD Artworks Investigator Kirsty Millar, Ph.D. Mariana Pereira, Ph.D. at Houston Sarah J. Hart, Ph.D. University of Edinburgh SUZANNE AND JOHN GOLDEN University of Massachusetts, Amherst University of North Carolina at Chapel Hill Young Investigator Suzanne and John Golden Investigator Young Investigator Carol Jahshan, Ph.D. Young Investigator MIRIAM KATOWITZ AND ARTHUR RADIN Simon Trent, Ph.D. Young Investigator Brentwood Biomedical Research Institute Wesley Brian Asher, Ph.D. Independent Investigator Katowitz/Radin Investigator Cardiff University Jason K. Johannesen, Ph.D. Research Foundation for Mental Hygiene, Inc./ Peng Jin, Ph.D. Yale University NARSAD RESEARCH FUND NYSPI/ Columbia University Emory University Young Investigator Young Investigator Domenici Investigator Frederick Charles Nucifora, Carmen Varela, Ph.D. Young Investigator Young Investigator GOLDEN RULE FAMILY FOUNDATION Ph.D., D.O., M.H.S. Massachusetts Institute of Technology Sangwon F. Kim, Ph.D. Young Investigator Santhosh Girirajan, M.B.B.S., Ph.D. Golden Rule Family Foundation Johns Hopkins University School of Medicine/ University of Pennsylvania Megan Lee Fitzgerald, Ph.D. Pennsylvania State University Investigators Johns Hopkins University Young Investigator Columbia University Qi Wang, Ph.D. Young Investigator Young Investigator Young Investigator CAROLE AND MARVIN LEICHTUNG Columbia University Janghoo Lim, Ph.D. NARSAD RESEARCH FUND Tija Carey Jacob, Ph.D. Chun Hay Alex Kwan, Ph.D. Leichtung Family Investigators Yale University School of Medicine Stephen G. Doochin Memorial Investigator University of Pittsburgh Yale University Young Investigator Yale University Young Investigator Nan Yang, Ph.D. Young Investigator Young Investigator BONNIE AND ALAN HAMMERSCHLAG Danai Dima, Ph.D. Stanford University Young Investigator David Louis Pennington, Ph.D. Roozbeh Kiani, M.D., Ph.D. Hammershlag Family Investigator Institute of Psychiatry/King’s College London Edward O. Mann, D.Phil. Northern California Institute for Research New York University Young Investigator University of Oxford and Education/ University of California, Young Investigator Young Investigator Wenchi Zhang, Ph.D. San Francisco Young Investigator Shinichi Kaho, M.D., Ph.D. Jacob C. Garza, Ph.D. Johns Hopkins University Young Investigator Markita Patricia Landry, Ph.D. Johns Hopkins University Massachusetts General Hospital Frederick Charles Nucifora, Ph.D., NARSAD RESEARCH FUND University of California, Berkeley Harvard University MILTON & TAMAR MALTZ FAMILY D.O., M.H.S. Daniel X. Freedman Investigator JOHN KENNEDY HARRISON FOUNDATION Johns Hopkins University School of Medicine Young Investigator John Kennedy Harrison LAUREN LEVINE Maltz Investigators Johns Hopkins University Young Investigator Jacqueline Morris, Ph.D. Investigator Levine Investigator Christiaan H. Vinkers, M.D., Ph.D. University of Pennsylvania Distinguished Investigator Young Investigator University Medical Center Utrecht Young Investigator Young Investigator Bruce M. Cohen, M.D., Ph.D. Arun K. Tiwari, Ph.D. Utrecht University Chung Sub Kim, Ph.D. Paul Siegel, Ph.D. Harvard University Centre for Addiction and Mental Health University of Texas at Austin Purchase College/SUNY University of Toronto

74 ANNUAL REPORT 2016 www.bbrfoundation.org 75 NARSAD RESEARCH FUND Young Investigator Young Investigator PROJECT HOPE Young Investigator Young Investigator Gwill Newman Memorial Investigator Becky Catherine Carlyle, Ph.D. Caroline Menard, Ph.D. Project Hope Investigator Yen-Yu Ian Shih, Ph.D. Chihye Chung, Ph.D. Yale University Icahn School of Medicine at Mount Sinai University of North Carolina at Chapel Hill Konkuk University Young Investigator Young Investigator Rachel L. C. Mitchell, Ph.D. Young Investigator Young Investigator Sergi Papiol, Ph.D. VIRGINIA SILVER Young Investigator King’s College London Ramesh Chandra, Ph.D. Sho Moriguchi, M.D. Ludwig-Maximilians University, Munich Silver Investigator Lara C. Foland-Ross, Ph.D. University of Maryland, Baltimore Centre for Addiction and Mental Health Stanford University NEW YORK WOMEN’S COMMITTEE University of Toronto Young Investigator Women Breaking the Silence About Mental Young Investigator MARC RAPPAPORT Eleonore Beurel, Ph.D. Young Investigator Illness Investigators Christine Ann Denny, Ph.D. Young Investigator Rappaport Family Investigator University of Miami Milena Girotti, Ph.D. Research Foundation for Mental Hygiene, Inc./ Veronica Musante, Ph.D. University of Texas Health Science Center Young Investigator NYSPI / Columbia University Yale University Young Investigator JOHN AND POLLY SPARKS at San Antonio Lynnette Astrid Averill, Ph.D. Theodore D. Satterwaite, M.D., M.A. FOUNDATION Yale University Young Investigator Young Investigator University of Pennsylvania John and Polly Sparks Foundation Young Investigator Miguel Angel García-Cabezas, Alexander R. Nectow, Ph.D. Investigator Ramiro Salas, Ph.D. Young Investigator M.D., Ph.D. Princeton University WILLIAM RISSER CHARITABLE TRUST Baylor College of Medicine Estefania Pilar Bello, Ph.D. Boston University William Risser Charitable Trust Young Investigator Instituto de Fisiologia y Biofisica Young Investigator Investigators Kai Xia, Ph.D. Young Investigator Bernardo Houssay/ University of Buenos Aires Young Investigator Marcia J. Ramaker, Ph.D. University of North Carolina at Chapel Hill Eric Floyd Schmidt, Ph.D. Nils Christian Gassen, Ph.D. University of California, San Diego Young Investigator The Rockefeller University Young Investigator Max-Planck Institute of Psychiatry Katie Lynn Nugent, Ph.D. BARBARA AND JOHN STREICKER Laura K. Fonken, Ph.D. Max-Planck Society/Max Planck Institutes Young Investigator Maryland Psychiatric Research Center Barbara and John Streicker VITAL PROJECTS FUND INC. University of Colorado Denver Matthew James Robson, Ph.D. University of Maryland Investigator Vital Projects Fund Inc. Investigators Young Investigator Florida Atlantic University Young Investigator Georgia Eve Hodes, Ph.D. Young Investigator Young Investigator Young Investigator James J. Prisciandaro, Ph.D. Virginia Tech Young Investigator Erik B. Oleson, Ph.D. Thomas J. Whitford, Ph.D. Irina Esterlis, Ph.D. Medical University of South Carolina Karen M. Ryan, Ph.D. University of Colorado Denver University of Melbourne Yale University Young Investigator Trinity College, Dublin OSTERHAUS FAMILY Carrie Holmberg, M.D., Ph.D. SCOTT-GENTLE FOUNDATION EVELYN TOLL FAMILY FOUNDATION Young Investigator Jeanne Marie Lee Investigator Stanford University Young Investigator Scott-Gentle Foundation Investigator Evelyn Toll Family Foundation Jieun E. Kim, M.D. Julia Sacher, M.D., Ph.D. Investigators Ewha W. University Independent Investigator Young Investigator Max-Planck Institute of Brain Research Young Investigator Kristen Jennifer Brennand, Ph.D. Dawn F. Ionescu, M.D. Max-Planck Society/Max Planck Institutes Kazue Hashimoto-Torii, Ph.D. Young Investigator Young Investigator Icahn School of Medicine at Mount Sinai Massachusetts General Hospital Children’s Research Institute (CRI) Lot de Witte, M.D., Ph.D. Wendy K. Marsh, M.D. Harvard University Young Investigator Children’s National Medical Center University Hospital Utrecht University of Massachusetts Medical OXLEY FOUNDATION Jaclyn Marie Schwarz, Ph.D. Utrecht University School, Amherst Oxley Foundation Investigator Young Investigator University of Delaware ELLEN SCHAPIRO & GERALD Clare Kelly, Ph.D. AXELBAUM Young Investigator WAREHAM FAMILY Young Investigator Trinity College, Dublin Young Investigator Ellen Schapiro & Gerald Axelbaum R. Matthew Hutchison, Ph.D. Adam S. Weisman Investigators Haggai Sharon, M.D. Giulia Treccani, Ph.D. Investigators Harvard University Tel Aviv Sourasky Medical Center Young Investigator University of Milan Young Investigator Tel Aviv University Hee-Dae Kim, Ph.D. Young Investigator Young Investigator Stephanie Dunkel Smith, Ph.D. University of Arizona Young Investigator Christine Elizabeth Gould, Ph.D. Jianping Zhang, M.D., Ph.D. University of Southern Mississippi P&S FUND Minghui Wang, Ph.D. Palo Alto Veterans Institute for Research Zucker Hillside Hospital Campus of the P&S Fund Investigators Young Investigator Cold Spring Harbor Laboratory (PAVIR)/ VA Palo Alto Health Care System (VA) Feinstein Institute for Medical Research WEISMAN FAMILY FOUNDATION Mary Claire Kimmel, M.D. Adam S. Weisman Investigators Independent Investigator University of North Carolina at Chapel Hill Young Investigator Young Investigator VAN AMERINGEN FOUNDATION, INC. Chadi A. Calarge, M.D. Samuel Wilkinson, M.D. Johanna Molly Jarcho, Ph.D. van Ameringen Investigators Young Investigator Baylor College of Medicine Young Investigator Yale University School of Medicine Stony Brook University School of Medicine Danielle M. Andrade, M.D. Yevgenia Kozorovitskiy, Ph.D. Yale University Independent Investigator University Health Network, Young Investigator Northwestern University Young Investigator Ramin V. Parsey, M.D., Ph.D. University of Toronto Priti Balchandani, Ph.D. Young Investigator Ting Lu, Ph.D. Stony Brook University School of Medicine Icahn School of Medicine at Mount Sinai Young Investigator Nolan Ryan Williams, M.D. University of Illinois at Urbana-Champaign Joelle LeMoult, Ph.D. Stanford University Young Investigator Young Investigator Stanford University Young Investigator Sofya Abazyan, Ph.D. Mounira Banasr, Ph.D. Carolyn I. Rodriguez, M.D., Ph.D. Johns Hopkins University Yale University Stanford University

76 ANNUAL REPORT 2016 www.bbrfoundation.org 77 Cantor Fitzgerald Relief Fund The Northern Trust Company Mr. Donald E. Benkeser DONORS Celgene Corporation Dr. Herbert Pardes and Dr. Nancy Wexler Mr. and Mrs. P. Bruce Benzler Mr. Benjamin T. Cheney Mr. Daniel Pipinich Mr. and Mrs. Brian Berger We are truly grateful for the generosity of caring individuals, foundations, and members of the Ms. Barbara M. Christy Professional Risk Management Services, The Herman Berger Family Trust community who make our work possible. Ms. Susan C. Bourget and Inc. (PRMS) Mr. and Mrs. Thomas M. Bergers Dr. Peter G. Coles Mr. and Mrs. Robert B. Rosen Mr. Michael Berman Distinguished $250,000+ The Weisman Family Foundation The Estate of Howard Eklind Dr. and Mrs. Thomas B. Coles Ms. Luauna Rule Mr. and Mrs. Gene Bernardoni Mr. and Mrs. Ilya Fleishman Collins Building Services, Inc. (CBS) The Nancy Ruth Fund Mr. Russell M. Best The Carmel Hill Fund Leaders $25,000+ The Gaddis Family Foundation, Inc. Command Financial Press Corporation Ms. Sarah L. Schnarr Mr. Nathan Betnun The Estate of Jane C. Eaton Michel and Claire Gudefin Family Mary Cooney & Edward Essl Foundation Mr. and Mrs. Richard W. Schumacher Mrs. Marilyn M. Bever Flora Gotz 1998 Trust ANONYMOUS Foundation, Inc. Dr. Margaret J. Drury Ms. Cheryl Schweighardt Mrs. Anne L. Bird Mr. Stephen A. Lieber Mrs. Jan I. Abrams Mr. and Mrs. John E. Hart Will & Ann Eisner Family Foundation, Inc. Ms. Yvonne De C. Segerstrom Mr. Elliott Blake The Estate of Nicholas A. Major The Blue Oak Charitable Fund Catharine Hawkins Foundation The Warren and Deb Fisher Mr. Denton Seilhan and Mrs. Michelle Blaskowski Maltz Family Foundation Graham Boeckh Foundation Ms. Jamie Heinemeier-Hansson and Mr. Charitable Fund Ms. Cathy Cole-Seilhan Dr. and Mrs. Harold Bloom P&S Fund Mr. Ben T. Bowdre David Heinemeier-Hansson Mr. and Mrs. Robert W. Geyer Elinor Beidler Siklossy Foundation Blue Tube, Inc. Estate and Trust of Jane H. Rowen Mr. and Mrs. E. Everett Deschner The Henry Foundation Mr. and Mrs. Thomas G. Gillis Mr. and Mrs. Sanford Sirulnick Dr. and Mrs. Benje Boonshaft The R. David Schreiber Amended Trust Mr. and Mrs. Brian Edwards Mr. and Mrs. Larry J. Hinman Dr. John W. Gonzalez Kenneth H. Sonnenfeld, Ph.D., J.D. Dr. and Mrs. Andrew S. Boral The Estate of Gary S. Sevitsky EOS Foundation Hope Foundation D.W. Gore Family Foundation Mrs. Patricia B. Specter Mr. Claude Accum and Ms. Diana D. Henry B. Test Trust Golden Rule Family Foundation Mr. and Mrs. Martin B. Jacobs Ms. Eva K. Grove Team Daniel Running for Recovery from Bradley-Accum Mr. and Mrs. Alan Hammerschlag Jewish Federation of Metropolitan Chicago Mr. and Mrs. Martin Gundersen Mental Illness, Inc. Mr. Richard Bretz Benefactors $100,000+ John K. Harrison The Ina Kay Foundation Marilyn G. Harwood Fund Tulchin Family Foundation Bridgehampton National Bank Independent Charities of America Quentin J. Kennedy Foundation Mr. and Mrs. David Herzer Mr. Paul Williams and Ms. Leslie Berger Mr. and Mrs. Peter M. Briscoe ANONYMOUS International Bipolar Foundation (IBPF) Mrs. Gertrude Kornfein Mr. Arthur W. Hills and Ms. Mary Mr. Nima H. Zahedi Mr. James Brook and The Anne and Ronald Abramson The Rona Jaffe Foundation Ms. Karin Kuhns Pilkington-Hills Ms. Isabelle Pinzler-Brook Family Foundation The Kaplen Foundation Mr. and Mrs. Wesley McDonald Dr. Karen Hobbs Associates $1,000+ Ms. Deborah Brown The Attias Family Foundation Mr. and Mrs. Marvin Leichtung The Emil and Toby Meshberg Mr. Christopher W. Homyk Ms. Lisa Brown Mr. Gerald Axelbaum and Carole and Harvey Mallement Family Foundation Horizon Group Properties ANONYMOUS (10) Dr. and Mrs. William J. Brownstein Ms. Ellen J. Schapiro The Milton and Tamar Maltz Mr. and Mrs. Rodger L. Nelson The Estate of Greta Horn Mr. Howard and Dr. Hinda Abramoff Mr. and Mrs. Michael Burczak The Roger D. Clark Discretionary Trust Family Foundation New York Presbyterian Hospital Mrs. Suzanne C. Hoyt Dr. Mark H. Kinn and Ms. Hannah Mr. and Mrs. Paul T. Burke Mr. Brian J. Cohen The Estate of Jonathan Mandel NYS Office of Mental Health Instacart Achtenberg-Kinn Mr. and Mrs. Jay Bushnell Maureen Hack Trust The Margaret Clark Morgan Foundation QMT Associates, Inc. A.C. Israel Foundation, Inc. Ms. Mayuree D. Adams Mr. and Mrs. Robert L. Buss The Matson Family Foundation New York State Psychiatric Association, Inc. Mr. Marc R. Rappaport Mr. and Mrs. Thomas B. Jahncke Mr. and Mrs. Brian K. Adams William F. Byerley, M.D. R-SB Harbinger Corporation The Lee and Herman Ostrow Family Mr. and Mrs. Mario J. Rossi Mr. James P. Jamilkowski Dr. David Adler Ms. Celeste Cademartori Mr. John W. Stackhouse Foundation The Rothschild Family Foundation Janssen Pharmaceuticals, Inc. Ms. Amy L. Alexander Ms. Catherine Caldwell Harriet and Esteban Vicente Foundation Otsuka America Pharmaceutical, Inc. Ms. Marylou Selo Mr. and Mrs. Patrick L. Johnson Mr. John S. Miner and Mr. James M. Call Vital Projects Fund, Inc. The Oxley Foundation The Estate of Shirley Shuster Mr. Kevin Kielbasa Ms. C. Nelle Alexander Mr. and Mrs. Grey B. Callaham Renate, Hans & Maria Hofmann Trust The Sita Foundation King & Spalding, LLP Mr. Peter Alexander and Ms. Alison Starling PJ Callahan Foundation, Inc. Pacesetters $50,000+ William Risser Charitable Trust Mr. and Mrs. Daniel A. Small Ms. Ellen Krantz Mr. Zachary J. Allen Mr. David Calvin and Ms. Constance Page Mr. and Ms. Curt Robbins Sunovion Pharmaceuticals, Inc. Mr. Walter Krebsbach and Ms. Rebecca Amatangelo Mr. and Mrs. Joseph S. Campbell ANONYMOUS (2) Scott-Gentle Foundation Vention Resources, Inc., PBC Ms. Andrina Hougham AmazonSmile Mr. William F. Campbell, Jr. American Psychiatric Foundation Dr. and Mrs. Mark Silver Ms. Marilyn Waldman The Jan M. & Eugenia Krol Charitable Mr. Donald Amen Candlewood Lake Boat Rentals, LLC Borrego Foundation, Inc. The John and Polly Sparks Foundation YourCause, LLC Foundation Ms. Mary R. Anderson Dr. Scott C. Berk and Ms. The Pauline Davis 1987 Family Trust Dr. and Mrs. Douglas A. Treco Mr. and Mrs. Howard Levine Mr. and Mrs. Uri Aqua Kathryn A. Cannon Beth and Rob Elliott Sponsors $5,000+ Dr. Piero Dalerba and Ms. Serena Arancibia Law Office of Eileen Caplan Seaman Robert and Rita Elmen Foundation Patrons $10,000+ Ms. Cynthia A. Luppen Arbor Research Collaborative for Health Mr. and Mrs. Gerald Capodieci The Joseph and Susan Gatto Foundation ANONYMOUS (6) Ms. Florence C. Mahoney Athena Capital Advisors, LLC Mr. and Mrs. James J. Carroll Suzanne and John Golden ANONYMOUS Ben’s Memorial Mile The Chris & Melody Malachowsky ATI Specialty Materials Mr. and Mrs. Steven L. Carson Gloria Harootunian Revocable Trust The Aderhold Family Foundation Ms. Eleanor Betz Family Foundation Mr. and Mrs. R. Walter Bachman, Jr. Mr. Paul G. Caslavka Robert Krebs Memorial Fund The Allergan Foundation Mr. Gregg Betz Dr. Irving Jacobs and Ms. Jeanette Matye Ms. Arleen Baez Mr. and Mrs. Daniel J. Castellani Lakeside Industries, Inc. American Endowment Foundation Mr. and Mrs. Michael F. Bishay Maurie & Ethel Meltzer Family Foundation Mr. Sudha Balasuryan and Castles In the Sky, Inc. Frances Link Matthews Charitable Fund The Benevity Community Impact Fund Dr. and Mrs. Jeffrey Borenstein Thomas G. and Andrea Ms. Geeta Kannan Mr. and Mrs. Tommy Y. Chan Mr. and Mrs. John R. Osterhaus The Adina L. Bernreuter Revocable Trust Ms. Sharon E. Bowyer Mendell Foundation Mr. Stephen Balek Ms. Susan Chandler Mr. Arthur J. Radin and Ms. Miriam Katowitz Mr. and Mrs. Robert T. Blanchard The Elise and Andrew Brownstein Mr. and Mrs. Daniel Mueller Mr. Jeff Bargmann Ms. Jill M. Chapman and Roy H. and Natalie C. Roberts Family Mr. and Mrs. Donald M. Boardman Charitable Trust Network For Good Ms. Marybeth Barraclough Mr. Richard K. Allen Foundation Gilbert & Ildiko Butler Family Jeffrey J. and Mary E. Burdge Gertrude B. Nielsen Charitable Trust Mr. and Mrs. Richard A. Bartlett Charlottesville Area Community Helen B. Schlecht Trust Foundation, Inc. Charitable Trust Ms. Carol Nobel Hirsh and Mr. and Mrs. Michael Becker Foundation Mr. Jason D. Stipanov Columbia University Ms. Sandy Cademartori Mr. Michael Hirsch Mr. and Mrs. Mitchell Becker Mr. and Mrs. George Childs Kohn The Evelyn Toll Family Foundation Mr. and Mrs. Richard A. Edwards Ms. Sally Cameron Mrs. Rachel A. Norris Mr. and Mrs. Robert W. Belyea

78 ANNUAL REPORT 2016 www.bbrfoundation.org 79 Mr. Bradley Green and Mr. and Mrs. John Fidaleo Harris Foundation Mr. and Mrs. Andrew Keegan Mr. and Mrs. Joseph K. Maiuro Ms. Julia Pastor Ms. Jennifer Chou-Green Fidelity Investments Charitable Gift Fund Ms. Harriet M. Hart Kehl Family Fund Mr. George W. Mrus and Mr. and Mrs. S. Giles Payne Mr. Randolph F. Christen Mr. and Mrs. Lincoln Fillmore The Robert D. & Reine Hartley Dr. Eric Keisman Ms. Eileen A. Mallesch Dr. Arthur Peck Ms. Barbara L. Chuko The Fine Foundation Charitable Foundation Ms. Elizabeth G. Keller Robert David Martin Estate Mrs. Mary J. Pedrosa Citigroup Business Services Dr. and Mrs. Roger L. Fischer Mrs. Esther M. Hartman Rabbi Abraham and Shirley Kelman Mr. and Mrs. Cornelius Marx Ms. Katie Penza CJR Foundation, Inc. Rabbi Lyle A. Fishman and Ms. Mr. and Mrs. Kenneth M. Harvey Charitable Foundation Mr. and Mrs. Josiah L. Mason Mr. and Mrs. Raymond C. Perkins Mr. and Mrs. Craig Clendening Debra A. Rosenman Dr. Samuel E. Hazen Mr. Romel R. Khan Mr. and Mrs. Bayard R. Maybank Perry Highland Women’s Dr. and Mrs. James E. Clune III Dr. Sharon K. Fitzpatrick-Fletcher Mr. Joseph P. Cothrel and Ms. Ms. Yvonne S. Kilbourne Mr. and Mrs. Thomas R. Mayer Association (PHWA) Mr. and Mrs. Joshua Cohen Mr. Kenneth Flanders Linda A. Heban Mr. Theo Killion Ms. Elizabeth M. McCarthy Mr. and Mrs. Ronald F. Persik Mr. and Mrs. Michael G. Coles Mr. and Mrs. David Flaschen Ms. Stacey Hefley Mr. Michael K. Klingher and Ms. Ms. Jolynne McDonald Mr. and Mrs. Seymour Pestronk Mr. and Mrs. John C. Colman Mr. Evan Flaschen Mrs. June M. Henebury Lindsay A. Schine Mr. Frank C. McLaughlin, Jr. Mrs. Marion F. Philips Ms. Eva Cooper Flint Hills Resources Grain, LLC Ms. Susanne Herb The Ko Family Foundation Ms. Katherine H. McNabb Mr. Jerome W. Pickholz Mr. Drew J. White and Ms. Letitia W. Ford Mr. Sheldon H. Herman Mrs. Helen P. Koskinas Mr. and Mrs. Ward McNeilly Mr. and Mrs. Mark J. Pietrak Ms. Emily Cootauco-White Ms. Betsy Foreman Mr. Michael M. Herron Mr. and Mrs. Howard G. Kristol Ms. Ellen C. Meadows Dr. Alex Porter Ms. Madeleine Cotton Mr. David Forst Mr. Jeffrey Hignight Mr. Bradey Krone Mr. Dennis Ladick and Mr. Roger Prior and Dr. Barbara A. Page Mr. Rodger Coyne Mr. and Mrs. Bradford F. Freer Ms. Mary P. Hines Mrs. Marilyn R. Krueger Ms. Karen L. Meadows Mr. and Mrs. Grant E. Propper Mr. Steven Cracknell Mr. and Mrs. Lewis L. French Mr. and Mrs. David A. Hirsch Mr. Thomas Gilroy and Mr. William Megowen Mrs. Linda J. Purdy-Ohland Dr. Margaret Crastnopol Ms. Helen Friedman Mr. and Mrs. Ralph J. Hitchcock Ms. A. Margaret Krugers-Gilroy Dr. and Mrs. Herbert Y. Meltzer Mr. and Mrs. Brad A. Purifoy Arie & Ida Crown Memorial Ms. Colleen A. Frobose Ms. Ruth A. Hodges and Mr. Shane Kucera Mr. Thomas W. Meyers Ms. Susan P. Quasney Mr. and Mrs. Stephen Cummings Mr. Michael Furhman Mr. John A. LeClaire Kuen Lau Research Foundation Mr. and Mrs. Bernard Meyers Dr. and Mrs. Mohammad E. Qureshi Dr. Joanna Curran Mr. and Mrs. Gary Furness Mr. Hal B. and Patsy Hollister Mr. and Mrs. J. Wesley Kussmaul Ms. Kimberly E. Millen Ms. Mary Radell Mr. and Mrs. Hugh P. Curtis Mr. O. Gene Gabbard Mr. and Mrs. Robert A. Holmstrom L&M Development Partners, Inc. Ms. Constance Miller Carol and Harvey Raff The Elizabeth H. Custer Revocable Trust Mr. and Mrs. Robert W. Gadsden Honokohau Properties Mr. James I. Ladge Ms. Debora L. Miller Mr. Jesse Rainin Mr. Reed D’agostino Ms. Catherine B. Gardner Ms. Karen E. Hopkinson Mr. and Mrs. Jim R. Lahti Ms. Joan H. Miller Mr. Jordan Raisher Mr. and Mrs. Edward H. D’Alelio Mr. Nicholas Garfinkle Barry H. Horowitz, C.P.A., M.S.T. Drs. Robert S. and Ann C. Laitman Mr. and Mrs. Michael E. Miller Mr. Terizhandur Ramakrishnan Ms. Enid B. Dalkoff Mrs. Nancy S. Geller Anne S. Howells Charitable Trust Ms. Barbara Lancaster Mr. and Mrs. Paul D. Miller Mr. Ravi Ramamurti Dammann Fund, Inc. Mr. and Mrs. George W. Gephart, Sr. Mr. and Mrs. Scot W. Humphrey Mr. and Mrs. Guy Lanquetot Ms. Jane Miller-Faytinger Mr. Srinivasan Ramiah Mr. and Mrs. Aaron Daniels Mr. and Mrs. Leonard Gero Mrs. Hazel Hundert Mr. Alex Laputz Mr. Sydney A. Miller-Schaefer Mr. Anthony R. Rando Mr. John Daus Mr. and Mrs. Steven Gibson Rita G. Hungate, M.D. Mr. and Mrs. David Laubach Million Dollar Round Table Mrs. Margot E. Razziano Mr. Brock D. Davidson Mrs. Betty B. Giles Ms. Sarah M. Hunt Ms. Joan M. Lechner Foundation (MDRT) Mr. and Mrs. Somasekhara R. Rebala Mr. Robert J. de Rothschild Give with Liberty - Employee Donations Mrs. Gail J. Hurvitz Leeolou Charitable Fund Mr. and Mrs. Michael T. Mitchell Mr. and Mrs. Jerry B. Redden Mr. Joseph V. DeGaetano Mr. and Mrs. Ted S. Gladstone Mr. and Mrs. John A. Hurvitz Ms. Joanne Leung Dr. and Mrs. William J. Mitchell Ms. Nancy Reeve Mr. and Mrs. Richard DeStefano Mr. David S. Glynn Mr. and Mrs. Craig Hutson Ms. Annie F. Levine MMW Mr. and Mrs. Danny R. Reid Dr. and Mrs. Pedro M. Diaz Mr. and Mrs. Peter Goode Mr. Bradley S. Hvolbeck, Jr. Arthur S. Levine, M.D. Mr. and Mrs. Allen R. Moberly Mr. and Mrs. Sheldon M. Rein Mr. and Mrs. David Diffley Gordon Family Charitable Foundation Mrs. Mary T. Ingriselli Ms. Ellen R. Levine and Mr. and Mrs. Wendell C. Mohr Ms. Amaza A. Reitmeier The John D. & Jean E. Dinan Foundation Mrs. Martha S. Graham Mr. and Mrs. Louis Innamorato Dr. Richard U. Levine Ms. Vivek Moitra Mr. Bradley J. Reynolds Mr. and Mrs. William R. Dodds, Jr. Ms. Lorri Grainawi Dr. and Mrs. Mervyn Israel Mr. and Mrs. Daniel Levy Mr. J. Clifford Moos RFR Realty, LLC Reverend and Mrs. Richard L. Dowling Mr. and Mrs. David A. Gramlich J Squared Press, Inc. Mrs. Ellen F. Levy Mr. John E. Mosher Mr. and Mrs. William G. Rhoads Mr. Jamie Drake Ms. Sheila Grant Mr. Eric M. Jackson Libbey, Inc. Mr. and Mrs. Marcel Mouney Lawrence I. & Blanche H. Dr. Eric M. Dreyfuss Mr. and Mrs. Bennett G. Grau John Mary & Bernard Jacobs Foundation Dr. Edward Libby Mr. Michael S. Mudd Rhodes Memorial Fund, Inc. Mr. and Mrs. Thomas H. Duncan David E. Green Memorial Scholarship Fund Mr. Achyut Jajoo Mary M. Lieber Trust Harriett Murphy Living Trust Mr. and Mrs. Joseph J. Ricci Mrs. Anna Dunigan Mr. and Mrs. Jesse J. Greene, Jr. Ms. Tanya K. James Ms. Mary M. Lieber NAMI Newton Wellesley Eastern Ms. Rhoda G. Rice Ms. Elizabeth B. Dussan Mr. and Mrs. Kevin M. Greene Mr. and Mrs. Arthur Janousek Robert J. Lieber Charitable Trust Massachusetts, Inc. Mr. Derek Richards Julian I. and Hope R. Edison Foundation The David F. and Margaret T. Grohne Mr. and Mrs. Donald D. Jayne Mr. and Mrs. James Locatelli Ms. Catherine Nash Mr. Gage M. Richert Ms. Annikki H. Elkind Family Foundation Mr. and Mrs. Richard A. Jespersen Mr. and Mrs. John Lohmeier Mr. Venicio Navarro Max Robinowitz, M.D. and Carolyn B. Dr. and Mrs. Bulent Ender Mr. Samuel Gross Mr. David Jochum Lone Pine Foundation, Inc. Mr. and Mrs. Thomas B. Newell Robinowitz, M.D., Ph.D. Bonnie Englebardt Family Charitable Trust Mrs. Margaret E. Grube Mr. and Mrs. Thomas K. Johnson Mr. and Mrs. Harvey S. Long Ms. Diep Nguyen Mr. Arthur G. Robinson Richard B. Evans, M.D. Mr. and Mrs. Donald A. Gunness Mr. and Mrs. Peter S. Jonas Mr. Dan C. Lortie and Ms. Grace Budrys Ms. Mary M. Nicol Mr. and Mrs. Daniel G. Rodgers Mr. and Mrs. Preston Everdell Mr. Kunal Gupta Mr. Craig S. Jones Mr. Brian Loughrin Arthur C. Nielsen, Jr. Charitable Trust Dr. and Mrs. Alain Roizen Mr. and Mrs. Robert Faetanini Ms. Smeeta Gupta Mr. and Mrs. Jeff Jones Mr. and Mrs. L. Alan Lowry Mr. and Mrs. David Noack Ms. Kathleen F. Rorick-McNichol and Mr. Michael F. Falkner Ms. Renee M. Cassidy and Mr. Jordan D. Ms. Carol A. Kallen and Mr. Fred Burrell Ms. Isabella Lubin Edward John Noble Foundation, Inc. Mr. James D. McNichol Mr. and Mrs. Christopher Feeny Gushurst Mr. and Mrs. David R. Kampff Mr. and Mrs. Scott Lyons Mr. Marc Leaf and Ms. Debra Oaks-Leaf Ms. Raquel Ross Mr. Andrew Feest Mr. and Mrs. Rob Gushurst Mr. and Mrs. Michael J. Kastenholz Ms. Cheryl MacLachlan and OdysseyRE Foundation Mrs. Donald I. Roth Mrs. Stephanie Feinland Mr. Adam Haas The Estate of Lawrence C. Kastin Mr. Fred S. Gorelick Mr. Ellis M. Oppenheim and The Lewis Roth Family Foundation Mr. Daniel Feith Mr. and Mrs. Carl S. Hammer Mr. Alok Katkar Mr. Manju Madhavan Dr. Lois L. Oppenheim Mr. Paul N. Rotiroti Hyman & Susan Feldman Family Mr. and Mrs. Henry Hanau Ms. Francine Katz Mr. Donald Chin and Ms. Grace Mah Mr. and Mrs. Antonie H. Paap Mr. and Mrs. W. F. Rousseau Foundation Mr. Everette P. Hardy Ms. Elizabeth L. Kaye Beth Maher Family Foundation Ms. Cynthia Paar Mr. Daniel Roy Ms. Patricia Fernandez Mr. and Mrs. Norm Harper Mr. Dillion Kearns Mr. Kevin P. Maher Mrs. Bonnie A. Parker Dr. George Rozanski

80 ANNUAL REPORT 2016 www.bbrfoundation.org 81 Mr. Joshua Rubin Mr. Jordan Sorensen The Harold Wetterberg Foundation Dr. and Mrs. Ricardo Barboza Dr. Logan Crews Mrs. Margaret A. Flynn Mr. and Mrs. Donald Rully The Spangler Family Fund The Whetzel Family Charitable Trust Dr. Jack D. Barchas and Mr. Daniel E. Cromie Mr. and Mrs. H. Bruce Friedrich Mr. and Mrs. Arthur A. Russ, Jr. Ms. Maya Spivak Mrs. Phyllis Whisler Dr. Rosemary A. Stevens Dr. Areta V. Crowell Diana L. Furrow, LPC RZ Foundation Mr. Paul Sprague Mrs. Virginia J. Whitcombe Mr. Charles R. Barlow, Jr. Mr. Jose Cruz Gamma Kappa Chapter of The Petros K. & Marina T. Ms. Cullen Stanley Mr. and Mrs. R. Graham White III Mr. and Mrs. David O. Barrows Mr. and Mrs. Lawrence M. Cubitt Kappa Kappa Gamma Sabatacakis Foundation Ms. Susan E. Stanton The Estate of Helen White Dr. and Mrs. John R. Baudler Ms. Johanna S. Cummings Mr. Mateusz Gawel Mr. and Mrs. Reuben H. Saideman Ms. Elizabeth Steele Mr. Joel R. Wicks Mr. James A. Beer Mr. John W. Curtis and Mr. Jonathan J. Gelb Mrs. Willmetta P. Saldin Arthur & Edith Stern Family Foundation Mr. John P. Wierzba and Ms. Christina Bell Ms. Margaret A. Sarkela General Atlantic Ms. Mary C. Salpukas Mr. Gregory Stilwell Ms. Ruth A. Lane-Wierzba Mr. and Mrs. Elliot Berger André & Marilyn Danesh Fund Mr. Jeffery Gerbitz The Saltsburg Fund Mr. and Mrs. Ronald V. Stone Mr. Glenn Willett Mr. Thomas A. Berghausen Ms. Cheryl Daniel Theodore F. & Josephine Gerson Jack & Anita Saltz Foundation Mr. and Mrs. Richard Strasbaugh Mr. John C. Williams and Ms. Joy Griffin Mr. and Mrs. Ronald W. Berninger Mr. and Mrs. Paul J. Datta Philanthropic Fund Mr. and Mrs. Doug Sander Ms. Sarah Stratton Dr. and Mrs. Martin S. Willick Ms. Corinne Bicksler Mr. and Mrs. Joe D’Augustine M. Rameen Ghorieshi, M.D., M.P.H. Dr. William E. Sanson Mrs. Lynn G. Straus Mr. and Mrs. Steven Wils Ms. Gail A. Binderman Mr. and Mrs. Lawrence E. Davis Ms. Kelly Givens Mr. and Mrs. Jay Sarles Peggy Straw Advised Fund Mr. William Wilson Mrs. Michelle Blosch Dr. Jan De Bakker and Mr. and Mrs. Richard Glick The Walter Kenneth Sartory Family Trust Stronge Family Foundation Mrs. Patricia A. Winston Mr. Warren Bloys Mrs. Gerarda De Bakker Mr. and Mrs. Lionel Go Dr. Mark A. Satterthwaite and Mr. and Mrs. Timothy E. Stutzman Mr. and Mrs. John Winter Mr. David D. Boes and Mr. Henry DeAngelis, Jr. Mr. and Mrs. Jack Gold Dr. Lauren M. Pachman Mr. and Mrs. Mark Sullivan Brian Young Charitable Fund Ms. Martha Mayes-Boes Mr. and Mrs. Dennis F. Deely Mr. and Mrs. Samuel Goldblatt Mr. E. James Morton and Ms. Dr. and Mrs. Myron Susin Ms. Beverly Zabel Bondee Enterprises, Inc. Mr. and Mrs. Gaspare R. DeGaetano Mr. and Mrs. Richard S. Goldman Matthild C. Schneider Mr. and Mrs. Frank H. Swanson Mr. Hossein Zahedi The Boston Foundation, Inc. Dr. José DeLeon and Ms. Victoria Martinez Pierre and Paula Gonthier Ms. Constance Schnuck Mr. and Mrs. Gordon Tagge Mr. Kamran Zahedi Mr. and Mrs. Norman H. Bouton Jr. Mr. and Mrs. Dale A. Dellutri Family Foundation Mrs. Ruth B. Schoenrock Ms. May-Ling Tang Mr. Bruce Zeiser Mr. Lloyd Bowers III Ms. Drusilla D. Demmy and Mr. Henry E. Michael and Lola Goodstein Charitable Nina R. Schooler, Ph.D. Tarbell Family Foundation Mr. Charles Zeiser Ms. Heidi Bowlus Bowden Foundation Trust Mr. and Mrs. Steven Schoolman Mr. and Mrs. Geoffrey Tate Mr. John Zeiser Dr. Karen U. Breakstone Mr. and Mrs. Timothy J. Denison Ms. Laurie L. Gordon Mr. Daniel J. Schreiber Mr. and Mrs. William B. Tausig Mrs. Renee S. Zenker Mr. and Mrs. Barry Breuninger Ms. Helle K. DeSimone Ms. Esther Z. Gordon Schwab Charitable Fund Mrs. Elizabeth J. Taylor Mr. and Mrs. David T. Zimmer Bright Funds Foundation Mr. and Mrs. John DiGregorio Ms. Laila Gordy The Estate of David Schwartz TechnoBuffalo Mr. and Mrs. Philip Zimmerman Ms. Dale L. Brodsky Dr. Carl Dila Mr. Yasaman Gospodnetich Mr. Marc A. Schwartz Mr. Lee Yeow D. Teo Mr. Phillip Zook The Eric Brown Foundation, Inc. Mr. Neil DiLorenzo Mrs. Blair H. Gray Mr. Hans-Peter Schwebler Mr. Jorgen Thelin Mr. Aaron Zubaty Mr. and Mrs. Jeff Brown Ms. Rose F. DiMartino Mr. and Mrs. Edward A. Gray Dr. Lloyd I. Sederer and Mr. and Mrs. Greg Thien Dr. Carl N. Brownsberger and Mrs. Susan Ms. Jane Dobbins Mr. and Mrs. Gary R. Greenberg Ms. Rosanne Haggerty Mr. and Ms. Bob F. Thompson Supporters $500 + Brownsberger Ms. Erin Dobbs Mr. and Mrs. Robert J. Greenberg Ms. Emily Segal and Mr. Andrew Ellis Ms. Barbara Toll Mr. and Mrs. John C. Burke Dr. and Mrs. Stephen E. Dolgin Ms. Gwendolyn Greenfield Mr. and Mrs. Terence Seikel Mr. and Mrs. David Trainer ANONYMOUS (3) Mr. Kenneth Burns Mr. Mark Dostal Mr. and Mrs. Anthony Guagenti Seleni Institute / Seleni Mr. Marc M. Tretin 267 Hurricane Group Mr. and Mrs. Mike Burns Mr. Mathew Drinkwater and Dr. Adrienne Mr. Guy C. Guckenberger House Foundation, Inc. The Trewitt / Berlin Family Fund Ms. Vivian T. Abbott Mr. and Mrs. James M. Caiaccia Drinkwater Mr. Matthew Guerra Mr. and Mrs. Dennis M. Seremet Mr. and Mrs. Timothy C. Tuff Mr. and Mrs. Celso C. Aberin Ms. Sarah Callender Mr. and Mrs. Daniel Dugan Mr. William Gwaltney Ms. Sara Shankavaram Ms. Clara M. Ueland and Mr. and Mrs. Joel H. Abrams Ms. Wendy Cannon-Gunn Dulinski Family Foundation Mr. Tarek M. Habashy Dr. and Mrs. Sherman Shapiro Mr. Walter McCarthy Mr. and Mrs. Roger K. Abramson Mr. and Mrs. Paul Carothers Dr. and Mrs. Ronald S. Duman Mr. and Mrs. William R. Hacker Mr. Connor Shea United Way, Inc. Mr. and Mrs. Thomas J. Acton Mr. Peter B. Case Ms. Mary Eaton Mr. and Mrs. Joseph Hagerty Mr. and Mrs. John L. Sheldon Mr. and Mrs. Edmond D. Villani Mr. and Mrs. Edward Albers Mr. and Mrs. Joseph Chang Dr. and Mrs. Bennett Edelman Mr. and Mrs. Stephen Hague Shell Oil Company Foundation Mr. Samuel C. Vrooman Mr. and Mrs. Steven B. Alexander Mr. Stuart A. Chapman Mr. David Einhorn Dr. and Mrs. William H. Hague Matching Gifts Mr. and Mrs. Robert R. Walker III Mr. and Mrs. Charles E. Allen Ms. Rebecca Chen Mr. and Mrs. Michael G. Eller Mr. and Mrs. David Halpern Ms. Jean C. Sheller and Mrs. Ms. Penny H. Wand Mrs. Kimberly Allen Mr. Karl H. Christiansen Ms. Brenda Elliott Mr. and Mrs. Jerry M. Hamovit Roberta Fricker Mr. Paul M. Warner Dr. Lauren Alloy Mrs. Arlene Christopherson Ms. Rosamund Else-Mitchell The Handley Foundation, Inc. Mr. Ramachandra G. Shenoy Warren County Foundation Depository Mr. and Mrs. Shahriar Almasi Ms. Nikita Chugunov Mr. Sean Enck Ms. Tania Hanna Florence and Orville Shortlidge Ms. Sherry Warren Dr. Audrey S. Amdursky Mr. Mark W. Chutter and Ms. Lorna B. Ellis Mr. Peter Engeian Mr. Jack Harkins Charitable Trust Dr. Douglas Warsett and Ms. Susan Warsett Mr. John R. Anderson The Cincinnati Adult Baseball League Mr. Matt Erickson Mr. Christopher L. Harper The Sibley-Saltonstall Charitable Mr. and Mrs. Colin B. Watson Mr. and Mrs. Kurt Apen Ms. Lillian Clagett Ms. Kate S. Ezra Mrs. Claudine M. Harris Foundation Ms. Deanna Watson Apple Bank Mr. John Clark Ms. Mary Ellen Falk Dr. and Mrs. Michael S. Harrison Mrs. Lilian Sicular Theodore & Renee Weiler Foundation, Inc. Mr. and Mrs. Thomas W. Arenz Mr. John Clarke Mr. and Mrs. Gary S. Fields Mr. Benjamin J. Haskin Mr. Jeffrey M. Siegal Mr. and Mrs. Daniel J. Weis Mr. Rollin A. Armer Ms. Linda T. Coberly Ms. Rose Filip Robert W. Hayes, C.P.A. Silicon Valley Community Foundation Mr. and Mrs. Louis Weisman Auburn University Interfraternity Council Mrs. Arlene Cohen Ms. Anne Finestone Mr. John J.H. Phillips and Ms. Carolyn Healy Ms. Jeanne Silvers Dr. Myrna M. Weissman Mr. James Avallone Mrs. Karen L. Cohen FirstGiving Ms. Phyllis Heischuber Mr. Dan Simon Mr. Mark Welsh Mr. Bruce W. Baber Mr. and Mrs. Bertram J. Cohn Ms. Lois A. Fitton Mr. and Mrs. Brad W. Hentschel Mr. and Mrs. John B. Sisk Mr. and Mrs. Matt Wenger Mr. and Mrs. Thomas J. Bak Mr. Samuel W. Collard Mr. and Mrs. David D. Fitzgerald Mr. and Mrs. Henry L. Herman Mr. Christopher Skogen Mr. Austin Wertheimer and Mr. Brian Baker Ms. Karen F. Corsi Mr. Michael Fitzsimmons and Ms. Margie Ms. Jane A. Hewitt Mrs. Barbara R. Smith Ms. Caryl Goodman Mrs. Mary Baker Ms. Kathleen Corsi Crump-Fitzsimmons Mr. and Mrs. Marvin L. Higgins Mr. Jeremy J. Solt Mr. and Mrs. Michael B. West Ms. Claire Balgemann Mr. Timothy Cosgrove Ms. Elyse Flanagan-Hall Mr. and Mrs. Charles Hill Dr. and Mrs. Howard Somers The Westport Fund Mr. James G. Banghart Mr. Dan Coyne Ms. Lorraine Fleser Ms. Saralee G. Hillman

82 ANNUAL REPORT 2016 www.bbrfoundation.org 83 Mr. Marc Tretin and Mr. David M. Kristol Mr. Walter F. Mondale Ms. Ramya K. Raghavan Ms. Linda Spielman Mr. Mark R. Wiesenhahn and Ms. Dr. Janet C. Hoffman-Tretin Mr. and Mrs. Werner Kroll Dr. Enrique H. Monsanto and Dr. Barbara Mr. Kumar Rajan Ms. Anne M. St. John Carolyn A. Waldmann-Wiesenhahn Mr. Timothy A. Hood Richard J. Kruger Foundation Winkler-Monsanto Ms. Shwetha Ramakrishnan Mr. Ryan J. Stacklin Ms. Edith Wigler Ms. Jane Horwitz Drs. John H. Krystal and Bonnie Becker Mrs. Jane V. Montecillo Krishnamoorthy Ramesh, Ph.D. Mr. and Mrs. David Steffes Mr. David L. Williams Houghton Mifflin Harcourt Dr. Fikri Kuchuk Mr. Walter H. Moos Mr. Alexander Rances Stego Industries, LLC Mr. and Mrs. Richard P. Williams The Edward Houk Gallery Mr. Andrew Kump Morgan Stanley Mr. Thomas A. Rattigan Mr. Michael L. Stein and Ms. Laurie J. Butler Mr. and Mrs. Steven C. Wills Ms. Sheryl L. Howe Mr. Adam J. Kurtz Mr. and Mrs. Frank E. Morgan Mr. Charles Reed Mr. Michael Halpern and Dr. Mr. Darnell Wold Mr. and Mrs. Peter Howell Mr. and Mrs. George Lantos Mr. and Mrs. Rob Morrill Mr. and Mrs. David M. Reed, Jr. Nancy J. Steiner Mr. Gary W. Wolf M.S. Howells Foundation Ms. Stefanie Laputz Mr. and Mrs. Loren J. Morris Mr. Duane Reid Mrs. Kathryn Stevenson Mr. and Mrs. Richard A. Wolfe Mrs. Cathryn R. Huch Ms. Susan Lasker-Brody Prof. Thomas Muench Mr. and Mrs. L. David Ricci II Mr. and Mrs. Brent Stewart Mr. Morgan R. Dallman and Mr. and Mrs. Bob Hunter Ms. Jane Lawrence Mrs. Joyce Mullan Ms. Victoria A. Riddell Ms. Claudia C. Stewart Ms. Carolyn Woodruff Ms. Melissa Huther Ms. Jill D. Lawrence Ms. Meaghan E. Mullgardt Dr. James F. Riddle Ms. Marisa A. Stratelak Ms. Nancy E. Woods Mr. Natsuko Imaizumi Mr. Chae Lee Mr. James B. Munson Mr. Michael Ripberger Mr. Raghavan Subramanian Amy J. Worrell, VMD Instinet Ms. Dianne C. Leech Mr. Eric Murchison Mr. Frederic W. Ripley and Ms. Sharon Kirby Mr. and Mrs. Ram K. Sunder Mr. and Mrs. Charles R.B. Wright Mr. Brandon Isaacson Mr. and Mrs. Leif LeLoup Mr. John F. Mussman Ms. Stephanie Riven and Ms. Marilyn J. Tabor Ms. Joanne C. Yablonsky Mr. and Mrs. Jeffrey A. Jackson Ms. Karen Levine Mr. and Mrs. Lawrence B. Nadel Mr. Roger Goldman Dr. Kevin S. Tait Dr. and Mrs. Ernest I. Yahiro Mrs. Vivian B. Jackson Mr. Duane Lloyd Ms. Sangeeta Naik Ms. Min S. Ro Taking Strides Against Mental Illness Mr. Kenneth Young and Ms. Julie Landau Mr. and Mrs. Thomas A. Jacobs Ms. Mallory M. Logan Mr. Jose W. Nakasone Mr. Brian A. Robbins Mr. and Mrs. David W. Talsma L. Trevor Young, M.D., Ph.D. Mr. and Mrs. Sidney S. Jacobson Mr. and Mrs. Michael D. Logan NAMI - Eastside Support Group Ms. Michelle Roche Taylor Survivor’s Trust Mr. Alan Zafran Ms. Carolyn R. Jakopin Ms. Clara F. Londoner NAMI - FACE of Burlington County Mr. and Mrs. David Rockwell Ms. Trisha K. Thelen Ms. Faye Zahedi Ms. Jacqueline H. Jeng Ms. Colleen Lowmiller-Marwil NAMI - Saint Cloud Area Ms. Debra S. Rose Mr. Lukasz Thieme Ms. Fereshteh Zahedi Mr. David L. Johnson Ms. Ann Lowry NAMI - San Joaquin County Mr. and Mrs. John Ross Ms. Tunesha Thigpen Mr. Clement Zai Mr. and Mrs. Mitchell Johnson Mr. and Mrs. David Lubin Mr. and Mrs. Terry L. Nechuta Mr. and Mrs. Michael A. Ross Mr. Kris X. Thiruvillakkat Mrs. Donna Zambrano Mr. and Mrs. Schuyler W. Johnson Mr. and Mrs. Richard Lynch Mr. and Mrs. Charles L. Nemes Mr. and Mrs. Michael R. Rothman Mr. Christopher Thompson Mr. and Mrs. James N. Zartman Dr. and Mrs. Robert M. Joiner Ms. Amy Ma Mr. Daniel J. Neumann Mr. and Mrs. Charles M. Royce Mr. and Mrs. Robert C. Thorne Ms. Cathy Zhang Ms. Elizabeth B. Jones Mr. Jonathan Mabry Newbury Animal Hospital The RPG Crossing Community Mr. Joel C. Tillinghast Mr. Ian A. Zilla Ms. Mary E. Jones Mr. Douglas Macnab Ms. Kathryn A. Nuss Mrs. Carol A. Rudder Mr. Sam Toossi Ms. Karen Zimmer Mr. Daniel S. Jordan and Mr. Joseph Mannion Mr. and Mrs. Timothy O’Keefe Mr. James A. Sadewhite Mrs. Esther F. Trachtman Mr. Russell Zomback Ms. Claudia L. Ginsberg Mr. and Mrs. Edward Manzi Ms. Debbie O’Leary Ms. Judith K. Hall and Mr. Donald S. Sargent Mr. Lee E. Strom and Ms. Andrea P. Paul W. Zuccaire Foundation Justgive Mrs. Alison C. Marer Mr. Henrik S. Olsen and Mrs. Harriet R. Sarkaria Trewyn-Strom JustGive.org Mrs. Joanne L. Marian Ms. Deborah M. Mesmer Mr. and Mrs. Richard J. Schlueter Mrs. Kathleen Tripp Mr. and Mrs. Robert R. Kain Mr. and Mrs. William G. Martens III Dr. and Mrs. Hussein Omar Anthony A. Schmidt Family Foundation Ms. Fay M. Trowbridge Mr. and Mrs. Albert F. Kaiser Mr. Stephen C. Martinelli Mr. and Mrs. Richard J. Orr Mr. and Mrs. Edward J. Schoenecker Mr. William C. Turner Mr. Roham A. Kalkhoran Ms. Stephanie E. Mathieu Ms. Betty Ann Ottinger Ms. Susan Schwab The U.S. Charitable Gift Trust Mr. Matthew D. Kalos Ms. Abigail Matteson Mr. and Mrs. Leonard J. Owen Ms. Joann Schwentker Mr. and Mrs. Barry Uhlich Mr. and Mrs. Joseph J. Kaminski Mr. John W. Huberty and Ms. Christine A. Mr. Surya Panditi Mr. Joseph C. Seikel United Way of Tri-State Ms. Kathe Kane Mauro-Huberty Mr. and Mrs. Anthony Pardo Mr. Jared N. D. Selengut Mr. and Mrs. Gary Usher Ms. Billie Kasper Mr. John C. McCabe Mr. Eric Parlin Dr. Miriam Shenfeld Mr. David Van Brunt Ms. Lyndsey Kastein Mr. John G. McCarthy Dr. and Mrs. Roderic A. Parnell, Jr. Mr. and Mrs. David B. Shippey The John Van Der Laar Trust Ms. Helen M. Kastenholz Mr. Jacob McCutcheon Mr. and Mrs. Russell V. Parrish Mr. Ronald J. Carlson and Ms. Sachiko Mr. Brian Vassallo Ms. Sandra Kazlow Mr. Robert A. McDonald and Ms. Anne Mr. Mark R. Pawlak Shohara-Carlson Mr. and Mrs. Roger S. Vinton, Jr. Mr. and Mrs. Richard Keating Stewart-McDonald Mr. and Mrs. George E. Pawlowski Mr. and Mrs. Curtis A. Sidden, Jr. Mr. Robert W. Vogel Hale and Andrea Kell William M. McDonald, M.D. Ms. Karen Paxton Kenneth Siegel, D.D.S. Ms. Mallory Walker Ms. Sandra K. Killough Mr. Greg D. McGlaun Mr. Leland R. Payton Dr. Matt D. Silverman Ms. Jennifer Walsh Mrs. Lynn Kimble Mr. Bruce T. McGuire Mr. Jesse M. Abraham and Ms. Amy Peck- Dr. Daniel Simon Mr. Garrick Pursley and Dr. Jeanne Wanzek Mrs. Manisha Kimmel Ms. Anne McWilliams Abraham Joseph T. & Helen M. Simpson Foundation Mr. Darsh T. Wasan Mr. William H. Kirby and Dr. Lenore S. Kirby Meecorp Captial Markets Ms. Susan L. Peters Ms. Kathleen Simpson Waterbury Philanthropic Trust Mr. Robert Kirsch Mr. and Mrs. Rock Meng Mrs. Lindsey Phillips Mr. Craig W. Slater Waygate Foundation, Inc. Mrs. Diane Kitson Mr. Jeffrey Menick Dr. and Mrs. Richard N. Pierson Ms. Noreen B. Smiley Mr. Dan Webb Mr. and Mrs. Edward Kittredge Mr. and Mrs. David B. Merchant Mr. Michael Pitt Mr. Graham F. Smith John L. and Sue Ann Weinberg Foundation Mr. Daniel S. Klein Ms. Emerald Midkiff-Skaggs Mr. and Mrs. John Poisal Mr. Richard M. Smith Mr. and Mrs. Paul J. Weintraub Mr. Madhuri Kondepudi Dr. Gary L. Mihelish Mr. Michael Thompson and Ms. Julie A. Mr. Glen D. Smythe Mr. Howard P. Weiss The Curtis I. Kossman Foundation Andrew H. Miller, M.D. Poppi-Thompson Mr. Oluwakemi Soboyede Wells Fargo Community Support Campaign KPMG - Matching Gifts Program Mr. and Mrs. Harry W. Miller Mr. and Mrs. James Powers The Society for the Scientific Study of Dr. and Mrs. James D. Westhoven Mr. Nicholas Kramer Ms. Jaye Miller Process Pipeline Services, Inc. Reading (SSSR) Dr. Donna White Ms. Monaya M. Krause Mr. Joel C. Miller and Ms. Anja Slim Pro-Ed, Inc. Ms. Kerri D. South and Mr. Courtney D. Mr. and Mrs. Thomas C. White Mr. and Mrs. Joseph Krehel Mr. and Mrs. Kyle H. Moberly R.L.K., Inc. Goeltzenleuchter Ms. Liesl A. Wiederkehr Ms. Marjorie C. Brandriss and Ms. Dianne Modestini Mr. and Mrs. Stuart Rabner Mr. and Mrs. Ted Spetnagel David and Rae Wiener Foundation, Inc

84 ANNUAL REPORT 2016 www.bbrfoundation.org 85 MATCHING GIFT COMPANIES Rebecca Carroll Jonathan D. Falk Bonnie D. Hammerschlag MFS Investment Management Matching Gift Program Derek Case Families for BPD Research Hank Hanau Allstate - The Giving Campaign Microsoft Matching Gifts Program Mary Case Nancy Farley Heather Hardison, Ph.D. American Express Foundation Mutual of America Foundation Richard M. Casey Kathleen Faroni’s Son Liza Haroldson Amgen Pac Matching Gift Program NYSE Euronext Foundation, Inc. Matching Gifts Program Thomas and Mary Casey Beth and Stephen Farrell John K. Harrison II Bank of America Foundation Pfizer Foundation Matching Gifts Program Ari C. Cassell Dr. Lauren Feiden Kristen C. Harrison BNY Mellon Community Rinet Company, Inc. Alana Cataldo The Feliciano Family Reace B. Harrison Partnership Silicon Valley Community Foundation / eBay, Inc. Foundation Zachary M. Chambers Kassidy Fifer Andy and Lauren Hart Anne E. Casey Foundation Matching Gift Program TCF Foundation Sho Tin Chen Michele Fiotakis Eric Harty Charles Schwab Foundation The Amgen Foundation Chi-Tsai Cheng and Li-Chi Liu Gregory S. Fitzgerald Lucy Hathaway Chubb & Son, Inc. Amgen Foundation Staff Giving Programs Dayna Chiapelli Dan Folts Virginia Hathaway ConocoPhillips Matching Gifts The Benevity Community Impact Fund/Benevity Social Ventures, Ben Chinitz Robin Forbes-Jones Sean D. Haynes Deutsche Bank Americas Foundation Inc./American Endowment Foundation Jesus Christ Thomas Frank Bernard and Mary Healy The Duke Energy Foundation Matching Gifts Program Thomson Reuters Brian J. Cohen Ron Fraraccio Heather FM Global Foundation UBS Michael Cole Robert R. Freedman, M.D. Raymond Hoffman The GE Foundation Matching Gifts Program United Way of Tri-State Peter G. Coles, M.D. Nicole Friedenberg Carolyn Holiday Give with Liberty Employee Donations Truist/ Truist Connect Thomas B. Coles, M.D. Friends of Joshua Bess and Krista Hodne Genevieve Hollis’ Nurse GlaxoSmithKline Foundation Visa Giving Station / Fronstream Lowell G. Colston Dorothy C. Fuqua Practitioner Colleagues Goldman, Sachs & Co. Matching Gift Program Frontstream Louise O. Colwell Michael D. Furay The Hollister Family Hudson-Webber Foundation WalMart/Walmart Foundation Thomas S. Cosentino Emilie Gannon John B. Hollister JMT Charitable Foundation Wal-Mart Foundation Bill Cox Christina Garcia Alexandra Holterman John Hancock Financial Services Matching Gifts Program Wellington Management Company, LLP - Matching Gift Program Ryan Coyer Yvonne Gardiner Richard Horak Eli Lilly & Company Foundation, Inc. Matching Gifts Program YourCause, LLC Spencer Craddock David Gassner Melissa Horine Matching Gift Center Thomas Crane Susie Gaudioso Edmund and Victoria Hornstein The Merck Foundation James Crimp Theodore M. Gault Matthew Horton Patrick Crownover and Ryan Jane Jacoby Gavin Kevin Hughes Anne Cunningham Emma Gavino-Blanco Tara Hunter TRIBUTES Gregory T. Bak The Boudreau Family Kenneth Cyberski Oren Gazit Angela Hurtado Hayes Baker and Ella Salas Hannah Bovermann E. Daetz Tal Gazit Kenneth Hyacinthe Honor Tributes Michael R. Baker Rick Bowles and Kelly McDermott Josie Damiani Donna Geib Impact Team, University of Iowa The Baker-Salas Wedding Mark Brady Killian Dawson Geoffrey Rachel Imperial Honor Tributes Tony and Emily Bakshi Ernesto Bravo Sarah and Jason Day Marshall “Sam” Gilbert Sarah Imperial A Loved One Jon Banach Scott Breneman and Ilene Lund Daniel De Los Reyes Hedy Glickenhaus Douglas D. Inmon A Special Person’s 38th Birthday Sarah Bancone Brian Jeff DeBono Marina Gloria Louis Innamorato Anne Abramson Neil Barber Bright Antenna Records Rich DeCoudres Alan Goldblatt Thomas and Deborah Insel Adam and Megan Philip Barber Matthew Brill Katie DeGennaro Linda S. Golden Antonia Iyer Todd Adler Mr. and Mrs. Cyrus P. Barger Mary Brinati Gianna DeMedio Suzanne Golden Jackque and Matt Ladan Afrasiabi Amy Barnes Chip Broad Stephanie S. Dey Amanda Golding Lea E. Jacobs Sima Afrasiabi Susan K. Bass Desiree Brown James M. Diggins Nina Goldworth Henry James II Bradley J. Ahrens Adrienne Baumrind Helen Brown Elayna Dikeou Elizabeth Goodman James All who struggle with Mental Illness John C. Bayat Lindsey Brown Lisa Donahue Martin Goodman Maria Jarusinsky Struggling teenagers and young adults Gerald Begin Margaret F. Brown’s Mother Reed Donat Lalleh Gordy Timothy Jed everywhere Gregory Bell Dan Bryant Stephanie Doris Minna Gosman Jeff Those that need it Scott Benson Charissa Buehler Bobby Dowling Nadia Graciano Louisa Jenkins Jennifer Aluning Ellen Bernstein The Bums Dr. Eric M. Dreyfuss Gerald and Margaret Graff Jennie Dean Ambrose Julie Berra Peter Burke and Lizbeth Marquez Bob Duis Katie Graham John and Diane Jason Amezquita and Jaime Sara Bessman Noah Burns Judson Dunaway-Barlow Ann Grannis Chris Johnson and Madonna L. Barnett Myhre-Amezquita Jenna Best-Senese and Al Senese Christine Burrows Lauren R. Duran Melody Grant Chris and Patty Johnson The Anderson Family Jerry and Barb Billings Canden Byrd Joyce Dwight-Bolton Michael Green, Ph.D. Jeffrey L. Johnson, Pharm-D, PA-C Andy Frederick Bird Mr. and Mrs. Donald Calloway, Jr. Meghan Dwyer Ruth Greenberg Khadijah Jordan Christina E. Angelo John J. Birkenhier Dave and Constance Calvin Jeffrey Eilers David Greer The Kachuk Family Annie Christina Bishop-Feeny Justin Campbell Elders Patricia G. Griffin Jamie L. Kaiser Anthony Trevor D. Blades Ryan Cannon Stephanie Elg Dr. Ron Groat Rochelle Kaper Bobbie Arganian Gabriel Bloom Ben Caplan Elizabeth Epstein Gummy and Aunt Mel Karen Chris Avellone Daniel Bonesteel Brantley Carmichael Ernest and Susan Erickson Judith E. Gunther Kathy Michael Baber Mason Boothe Perry Carnahan Etsy.com/shop / The Positive Artist The Gushurst Family Sarah Kattakuzhy-Thomas The Backer Family Jeffrey Borenstein, M.D. Tony Carney Justin B. Evarian The Haas Family Daniel Katz Luke Bailey Eleanor Borst Adam L. Carolla Robert Fackelman Jennifer Halpin Joel Katz

86 ANNUAL REPORT 2016 www.bbrfoundation.org 87 Jason Keener James Loui Morgane Naveau Sargent Brian L. Roderick, USMC Becky Stodolak Owen P. Whalen Katie Keil Ingrid Lowery Neil Joseph A. Romolo Fred Stodolak Millie E. Wheat Claire Kelly John R. Lyons Gary Nesenson Sarah Rossman Jean L. Stone Sue Wheaton Leah Kemple Maureen Lyons New York District Key Club Division 8A Barbara G. Roth Alan Stoutz R. Graham White III and family Taryn Kennedy Samuel MacDavid Sarah and Ralph Newitter Faith Rothblatt Bruce Strain George White and family Brigid Kenney Marian Mace Nick Frances A. Rove Brian and Kayla Stutzman Tom Wickens Nancy Kenney Dana V. Maggi Delilah Noronha Gregg Rubin Carmen Suarez-Puell Jen Wiedel Mary W. Kenny Justin Magleby Cain Norris Daniel Ruiz Lynn Sullivan Lucas and Laura Wilcox Laura Kerch Margaret Mahon Jane Novick Mr. and Mrs. James C. Ryan’s Steve Suslow Terry Wilson Suzanne Kerns, M.D. Karen Maki Eileen Nutting Family Members Gregory Sutton Betty J. Winberg Charles Kessler III Allison Malikowski Arron N. O’Callaghan and Sean D.O. Smith Jia An Sa Jeffrey Sutton Wish-A-Mile Michigan donors and Kevin and Jennifer Carole H. Mallement Debra A. Ohlson Annemarie Sabatini Mr. and Mrs. Michael Szpak family members David and Megan King Milton and Tamar Maltz The Ojala Family Sahi Jeremy Taff Bill Wofford Michael Kirsic Oliver Manice Joshua D. Okun Edward R. Sanford Nick Talisman Mike Yamanaka Jack Kiser Kul Markan Lewis Opler, M.D., Ph.D. Carolyn Sargent Taylor Lee Yanez Nancy Kisseloff Tommy and Elizabeth Marrinan Nieves A. Ortiz James A. Sasser Sahar S. Tehran’s Beloved Brother David Yocom K-Lee Klein Marla Marsili Beth A. Osmun Mark A. Satterthwaite, M.D. Laura Terio, MSW, LCSW Douglas Yocom Katherine Klem Michael and Darcy Martin Patricia Page Lori Savage Josh and Valerie Thill Kate Yurgil Avni Kolluru Clairborne Mason Ananya Pal Stacy A. Savidge John Thorman Alex Zeigler Camille Koney James D. Mason IV John Pallikaras Kai and Malia Schmelzer August Thurmer and Lauren Machen Yaeko Zeigler Steve Korngut The Mathis Family Robert A. Papazian, Psy.D. Chloe Schmerberg Philip Thygesen Raleigh Zimmerman Emeline Kovac Matthew Herbert Pardes, M.D. Colette Schmidt Michael Tinti Angie Zoghbi Jennifer Kovac Stephen Maxsted Ashley Parker Colleen Schmidt Bosworth M. Todd, Jr. KP Hilary W. Maybank Lance Parker Tiffanie Schmidt Erik Topham Memorial Tributes The Kramer Family Mr. and Mrs. Baron McDougall’s Son Elizabeth Parlin Dr. and Mrs. Kenneth Schneider Amy Townsend Susanne Krehel Judith A. McIntosh Michael Pass Nina R. Schooler, Ph.D. Howard Trachtman A Loved One Howard and Shelley Kristol Jeff McKnight David Patton and Doug Hatch John R. Schoolman Traditions Behavioral Health Randy Abbott Thomas Kuljurgis and Heather James McLaughlin Dr. Arthur Peck Austin Schufreider Claire Tunakan Richard Hilstad “Hil” Charles Abbott Richardson-Kuljurgis Clay McNamee Joel M. Penny Pam Schulte Casey Turner John “Jed” B. Abrams Andy Kurmakov and Zoe Weinstein Mr. and Mrs. Medel’s children, Maria Peter Anita Scripter Seth Turner Marc D. Abrams Daniel Laitman and Miguel W. Scot Phillips Julia Scullion John Tursi Elizabeth Adams The Laitman Family Meena Carol Pinkham-Oak and and Jeff Oak Gary Segar Shirley Ueng Michael Adams Joe Lankheet Philip S. Mengel Carolyn A. Plumer Timaree Serna Ashley Umholtz Carlo A. Adan Nathan Lape Michael Paula Poat The Members of the Shenandoah Club The Ungar Family Jean M. Ahern Rachel LaQuercia Ruth Michelich Peter Politis Susan Sherman Martin Ureel William J. Albee David Lavner Hope Mickens Jeanne S. Porter Tessa Sieler Jaclyn Valadka Nicholas R. Albers Guneet Kochar and Julie Leber-Kochar Military Members with PTSD Dr. Steven Predmore Virginia M. Silver The Valenchik Family Jose M. Alegre Giancarlo Leon Benjamin T. Miller Tab and Dave Price Marcia Simon-Kaplan Jack and Anita Van Horn Alex Alexander Justin Leonard Edna Miller Sheryl Pringle Amelia Sims Sharlee Van Horn All who have fallen to Mental Illness Dr. Ira Lesser Taylor Miller Psi Chi at University of San Francisco (USF) Michelle Singh Juan Vargas Those that struggled with the ongoing fight Audrey Leung Jon Miser Sharon Purvis Isobel Slomowitz Greg and Susan Vasilakos Barbara Allison Levi Rylee Mitchell Thomas Quigley Glen M. Smith The Vega Family Helen E. Amatangelo Alan Levine Paul Moats Arthur J. Radin Irene Smith Joyce Villalon Vincent S. Amoroso, Jr. Susan J. Leviton Charles M. Moon III Debry Radtke Richard and Sue Smith Sandra S. Vinton Vivek Ananthan Daniel Levy The Morais Family Emily Rasmussen Stephanie Snell’s Aunt Judy Steven Vinton Blake G. Anderson Jason Li Angelina Morisi and Keith Chapman Raven Reaves Dr. Hannah Solky John Viola June A. Anderson Zach Liben The Morisi Family Kristen Record Anibal and Brandee Sosa Dustin and Carrie Voliva Robert C. Anderson III Dr. Warren (Wazzy) Licht Elizabeth S. Morningstar Sheldon and Edith Rein Anthony J. Spadaccini Ted von Rosenvinge and Linda Willis Sean R. Anderson Stephen A. Lieber Stephen and Rebekah Morton Johannes Reiter and Adeeti Ullal Alan Spandorf Katie Wagner Silas E. Anderson, Jr. James Lindenbaum Craig Moskowitz The Reznyks Jennifer A. Spangler Jennifer Ward Kathryn Anderson-Biddle Dr. Ya-Ling Liou’s Patients at the Practice Juliet Mowrey Rafaella Ribas Sue S. Speed Alfred Johnson and Emily Watts Olle Andersson Ronald E. Ljunggren Daniel Munson Rick Jeffrey and Sandra Stankiewicz Dawn M. Wayand Andre Lola Matthew Murray Catherine A. Riley David J. Starck Sharon Weinberg Christopher Andrusz Marilyn Lombard Alan Nadle Min J. Ro Robert Staszak and Ashley Rosaen Bob and Martha Weingard Mohammad Arshad, M.D. Michael B. Long Lucette Nadle David Robertson Mike and Mary Sterns Robert and Frances Weisman Christopher J. Awn Michael Lopez Grace Naguar Pamela K. Rocca Gary Stevens Robert S. Wenger and Susan Carney John J. Awn, Jr. Susan Lott Jessica Nargiso William and Elizabeth Roche Dr. Desanka Stipic Mike West Julius Axelrod, Ph.D. Cortney Loui NARSAD Rod Woody Stock Samantha J. West Chris Axmann

88 ANNUAL REPORT 2016 www.bbrfoundation.org 89 Catherine Bacon-Sudro Marilyn Burger Christopher Cowan Elisa T. Dulay, M.D. Clarence R. Garrett III Jason R. Hargarten Gina M. Bailey Chantal M. Burke Imogene Craig Edward J. Dunlap Mike Gasche John B. Harlow Robert L. Bailey Colleen M. Burke James W. Cramer Alexander Duno Dorothy Gaubert-Pyle Michael V. Harrington Anna Balek Anttwion D. Burks Jimmie D. Croy Eric Durrant Edwin Gault Brent A. Harshman Scott Balgemann Bernadette R. Burns Oveta Croy Eric A. Dutch Tyler J. Gebhard Michael C. Hazzard Marianne Banerjee Evan Busbey Stacey M. Culotta Alan Dutka Sein Hee Leong Gee Kevin Heald Robert P. Banghart Cecilia Buster Patrick Cunning Atta Eckardt Richard J. Geiger Kevin J. Healey Edward R. Barch Patrick T. Butters Joan M. Curtin Virginia Ecoff Sumner Germain Jimmy Hehir Robert J. Barlow Jacob Byers Benjamin S. Custer Dave Edwards Alexander J. Gerth Bradley R. Heilman Vince Baro Chaz G. Byrd Elizabeth H. Custer Howard A. Eklind Harriette L. Giber Eric Heins Dorothy G. Barraclough Dr. Eugene R. Cacciamani Lawrence Dalkoff Paul E. Ekstrand Steven H. Gibson Richard T. Heller Terrence Barraclough Paul C. Caisse Colter Dallman Christopher C. Elderkin Daniel L. Gil Frank R. Hellinger III Patricia A. Bartlett Scott Calcaterra Richard D. Daly Keith Emerson Rev. T. Edward Giles Scott L. Helt Scott Richard Bartlett Patricia Calia Mary A. D’Ambrose Michael Engelson Ted R. Giles Joan L. Hendricks Nicholas D. Battis Renée Callicott Julian D’Andrea Josiah Epps Ryan C. Gilroy Wilma Henry Bruce A. Baver Amy E. Calvin Stanley F. Dann Susan Estabrook-Kennedy Marietta M. Gjessing Todd Herman Heather K. Beals Donna Calwas Vincent A. Dann Audra Evans-Weinke David K. Glenn Russell M. Hickey The Bear Nicolas Canard Danny Marian “Molly” P. Everdell Stephen Glick Danny Higgins Meredith W. Beck Bob Caputo G. Joyce Darilek Neal Factor Linda Glieberman Leo Hillel Lawrence H. Bell, Jr. Israel A. Caraballo David Benjamin C. Faetanini Brian D. Go Lewis R. Hiser William D. Belter Izzy Carbello, Jr. Kenneth H. Davidson Gary Fagin Carol and Robert Godsey’s Mom and Dad Nicholas O. Hodgson Elizabeth P. Berg’s Grandmother Paul R. Carman Jean Davis Fay Dr. Patricia Goldman-Rakic Ian Hoffmann Adina L. Bernreuter First Officer David B. Carmichael, Jr. Pauline Davis Matthew J. Fee Rachel Goldring Hannah Holzman Kurt Bertram William R. Carney, Jr. Carter L. Davison Seymour Feinland Martin Goldsmith Dr. Philip S. Holzman Paul Bertsch Alexandra Carroll Janice Day Harold Feld Robert H. Gomer Judith A. Hood Jared R. Best, USMC Shirley L. Casier Daniel De La Vega Joan Feldman Barry M. Goodrich Evelyn Hornick Herbert Betz Dwight D. Cassidy A. Louise DeAngelis Dr. Judith F. Feldman Ethel G. Gordon Darlene K. Horton Kalyan Bhandari Mary Camille Casson Miron Decca Olga Feldman Nanci L. Gordon Dan Hoth Janice Bickett Suzanne L. Castellani Benjamin DeCrease Larry S. Felts, M.D. Christopher Gossman John D. Huberty Stephen J. Binder Robin E. Cathey Elizabeth A. DeFelix Alec Fentum Dr. Irving I. Gottesman Katherine A. Huebinger Victor Biondo Kevin P. Cavanaugh Thomas A. DeLong Olivo Ferrari Adam J. Grainawi David E. Hughes Lewis Bishop Lori L. Chadwick Janice A. DeLoof Frederick A. Findlen, D.M.D. Greg Gransberry Rennie E. Hughes Dr. Morton Black Joyce Champion Darlene Depto Kimberlee Fiore William F. Grant, Jr. William W. Humphrey Major David J. Blackburn Garvin Chandler Dick Derby Carrie F. Fisher Isabelle Graziano Alan N. Hundert Constance A. Blazy Scott M. Chauvin Brett G. Deyo Tom Fitzgerald Daniel Greenberg David R. Hutchison Heather A. Bleick Dale R. Cherney Nathaniel J. Dickinson Ruth Hamlin Flick Philip J. Greenberg Joseph Iacono Genevieve C. Blixt Matthew Cherney James A. Dirling, Sr. Raymond J. Flood, Jr. Melvin E. Greene Matthew J. Ibarría Charles F. Bodden, Sr. Steven J. Cheverton Kenneth Ditzel Thomas B. Flynn Mary Greener Edward C. Inglis Martin Boehm Andrew S. Christie Brandon Dixon Roger Fogelman Mark J. Greenlee David J. Ioele Kirk Boise Ann V. Christie Jonathan E. Dixon Helen T. Foley Ralph P. Grennon Domenik J. Ioven Thomas Boland Arlene B. Christopherson Valerie Domitrovic Diane Folkman Tommy Griffin Jane Irwin-Malinoff Bonnie Margaret Christopherson Tim Donley August M. Fons, Jr. John Grindstaff Courtney Ischinger William E. Booth Kelly Claghorn Linnea O. Donnell Dr. Bobby Fox’s Father Jason Grosskurth J. Edward Jackson, M.D. Steve Borer Ruth G. Clark Thomas Donnelly Jeremy France Jocelyn Grossman Shelly Jackson Kevin Bowers Viva Clark Christopher J. Donovan Mary Francis Christopher Grover Nyssa Jacobs Kristina Bracy Philip J. Clements Suzan Dort Krista K. Franseen Joe Guerrettaz Prayim L. Jacobsen Amy Braun Barbara Cogliandro August E. Doskey Robert L. Fredricksen, Jr. Karl Guhm Prem Jajoo David Braun Sherrie Cohen Douglas Lemmull R. Freer IV Thomas S. Gumport Sabrina I. James Concepcion Breslin Gary L. Cole, Sr. Karen Douglas Harvey Friedenberg Peter Gunness George R. Jameson David Breuer Peter M. Coleman Noah J. Douglas Jason C. Frisco Robert Haber Quincy Jang Catherine Briggs Alec Colón Mary M. Doyle Eric A. Fritts Lillian M. Hadalski Joseph Janush Mara Brightstar Thomas J. Colson, Jr. Rachel L. Drabenstott Christopher Furay Linda Haddican Gabe Jarrard Kim Brown John W. Connelly, Jr. Marilyn L. Drake Stanton Gagel Carlos E. Ham Robert K. Jay Bruce Brownlee Ryan J. Cook Colin Drew John A. Gahr, Jr. Florence Hammond Jean Ira R. Buchler Kathleen A. Cornell’s Sister Sandra G. Dreyfuss Mark Gallagher Kenneth B. Handley Charles Jenkins Edward G. Buckovich, Jr. Jim Costello Kyle DuBose David L. Gardner, Sr. Lawrence A. Hans Vaughn Jenkins Walter W. Bundschuh Glenn C. Cotham Michael Ducate Heidi M. Garoutte Matthew Hardin Joe Peter R. Bunning Lillian A. Cottignies-King Christopher R. Dugan William M. Garrand Wes Hardin John

90 ANNUAL REPORT 2016 www.bbrfoundation.org 91 Eric Johnson Scott Larsen Roman Makuch Irene Moran’s Brother Dixon W. Pfefferkorn Ira Rose Michael D. Johnson Jenna R. Laubach Molly Malone Constance Morgan Larry Phillips Cindy Rosemeier Ryan P. Johnson Robert E. Lauer Dierdre A. Maloney Christopher Morrison Lynn Phillips Jonathan R. Roshon Vaughn E. Johnson Barbara Laurence Theresa A. Maney Barbara C. Mosher Parker E. Phillips II Alan G. Ross Sarah A. Johnson-Freeman Jerome C. Lawrence Alan G. Marer Danny W. Moudy Sybil Pierce Mitchell S. Ross Lisa Johnson-Greene Elizabeth Laws Frieda Margolis Howard E. Mueller Frederick Pilgrim Christina Rossi Herman Juffer Abby J. Lazar Adam Marron Ronald P. Mullan Patricia Pilgrim Donna J. Rossi June Joseph A. LeBlanc, M.D. Ryan Marsh William E. Mullen John Piniat Michael Roten Jeffrey C. Kain Rusell LeCours Elizabeth Martino Patricia Murawski Colin Pitt Lewis Roth Douglas J. Kaiser Brian D. Ledoux Caeser E. Massanelli Donna J. Murphy Laura Polansky Matthew S. Rothman Lawrence E. Kalom Anna (Kachisian) Lee Julia Masterman Mark A. Murphy John T. Porter II Ben Rottinghaus Steven Karp Jeffrey Leitz David Matalucci Tina M. Musso Elizabeth M. Posa Jane Rowen Savannah T. Karten Micah Lemerman-Shilcrat Thomas Matye Oakie Myers Michael R. Postal Kevin Rubinstein Curtis E. Kasper Roberta Leonardo Travis Matye Sean Myers Sheran J. Powers Chris Rudder Jeffrey Katzif Nicholas Leonhardt Maudie Michael E. Myron William R. Powers Donald J. Rully Titus Joe Kauffman Edward Lester Thomas W. Mayer Vincent Nacchio Matthew Presley John Rusch Claude R. Kaufman Jim Lester Michael McAdam Sarah Nack Oliver M. Priceman Nadeen Rutledge Miriam Kaufman Michael S. Levine William J. McAdams Shilpa Nagendran P.J. Purcell David Ryan Anne F. Keegan Dr. Joanne Levy Timothy P. McBride Matthew Nelson Ramez E. Qureshi Mark P. Ryan Daniel R. Keegan Beatrice Lewis Ryan McCarthy Daniel P. Newberry Lois Rafal Phillip C. Ryan Mike N. Kelly Mary Libby Michael McClain Norman M. Nordquist Sidharth Ramakrishnan Kenswynn Black Ryerson James Edward Louis Kempf Erma Liberty Lena J. McCleary Louis Novenson Margaret Ramsour Angela S. Andy Kendall Jacob Lichtenstein Skye McCole Bartusiak Russ Nugent Raymond Rando Agis Salpukas Michael F. Kenigsberg Hesh Lieb ben Yeshayahu Elma L. McDonald Brian O’Daniels Anthony Rankin Ann M. Salva Eric Kertzner Constance E. Lieber Jimmy G. McDonald Kenny Oetjen Sam Raskin John Samaritano Rashidul Khan Jonathan B. Lindenberg Robert McDonald Susan Okun Dr. Jacob P. Rayapati JoAnn Samels Jeanne C. King Hans K. Lindgren David McGibbon, Jr. Nancy M. Olandese Evan G. Rea Elaine Samson Jill A. Kirby Frances E. Link-Matthews Elmer H. McGilvray LeRoy Olcott John Reason August Sancis Raymond Kline Donna M. Lloyd Andrew McGowan Bruce Olmstead Lakshmi M. Rebala Rebecca Sandhoff John N. Klingel Dustin Locke McKenzie Alexandra Olson Brian E. Reese Anthony Santa Barbara Alexandra B. Knöppel Elaine M. Locke Summer McLellan-Shoats Ruth Oppenheim Michael R. Reese Lourdes M. Santos Michael Knutson Walter N. Lofgren David R. McPherson Cameron R. Orr Terence Reid Kerri N. Saunders Steven Kofsky Charles H. Logan James Meeks Ossie L. Ory Marci S. Reller Veera Saxena Christine Kohlstedt John S. Logue II Roderick W. Merrill Karl W. Overberg Linda J. Renner Betsy Scheld Peter C. Kohn Pranav Lohitsa Joshua K. Messier Zacchary L. Pace Steven Reno Victoria Scheld Dr. Jerome Komisarof Kyle C. Longton David Meyer Mary Pagani Mark S. Reuling Charles F. Schibener III Arty Kononchik Hector Lopez Mel H. Michaels Barbara W. Page James D. Reynard, M.D. Sterling A. Schiffman Helen Kopsky Brenda O. Lopez-Tintos Bradley J. Michel William U. Page Dorothy A. Reynolds Helga Schmidt-Gengenbach Pamela Koren Peter Lortie Apphia Michelich Ryan Palmer Dr. Sun Hong Rhie Nancy Schmitt Bill Korpela Victor G. Lottmann Ronald Michelich Devon Parent Scott T. Richards Lee Schoolmeesters Diane A. Koskinas Basil L. Loudas Mike Casey R. Parker Marcia Rickey James Schultz John B. Kramer, Jr. Joanna Lowry Harry Miller Dr. Gary Parker Peter Ripberger Sally Schulz Mark P. Kramer James M. Luerich Mark S. Miller Josiah E. Parker III Harvey Ripps Briana M. Schutze Robert Krebs Gary A. Lund Lori Miller-Levine Kathy Parker Joan Ripps Michael L. Schwartz Austin Krinder William C. Lund Marcella Mills Barbara M. Parks Jan Ritchie Jordan Seighman Bruce Krogmann Helene Lundak Mary Millus Paul A. Parris Jennifer B. Ritter Cindy Seikel Kendal Kucera Barbara Lupowitz Joseph A. Milukas Silas Parry Jonathon J. Robbins Paz Selo Nuri Kucuk Lupsis Samuel H. Mintz-Straus Julia Anne H. Patterson Trandl Robbins Werner A. Selo Madeline B. Kuflik Larysa S. Luzniak-Meyer Dave Mirra Marketa E. Patterson Florinette “Little Flower” Roberge-Schon Ellen Semmelhaack James Faires Kuykendall, Jr. Michael Lynch Jonathan Mitchell Logan Pauk Marcus Roberts Stephen Seserko Tanya Lace Shirley S. Lynne Ana L. Miyashiro Robert P. Pellegrini Steven G. Robinson Gary S. Sevitsky Scott B. Lais Matthew C. Lyons Janeth K. Mobley Kathryn M. Pendleton Elizabeth Rolland Bruce B. Shaffer Debbie Lange Keith MacDonald Rachel A. Moe Sydney L. Perkins Roman Shane Sheila Langlois Noel A. Machado Neil Molberger David J. Persik Henry J. Romney William Shannon Melissa A. Lanier John Macko Daniel W. Momyer Gregory S. Persik Mark P. Ronan Dr. Ed Shapiro Sandra J. Lanier Joel R. Maginley Gregory A. Monk Peter Paul J. Root Ruth Shapiro Katherine Lapierre, M.D. Anne Mahoney Raymond J. Monnot Jamie Peterson Brian Rorick Shalom Sharoni Mary Ann Lapinskas Iris Maine Kathryn Montgomery Todd A. Petriscak Tommy Rorick Terese M. Shaughnessy-Munroe

92 ANNUAL REPORT 2016 www.bbrfoundation.org 93 Mark Sheehan Atekelt Tadese’s Beloved Aunt Richard A. Wescott COMMUNITY PARTNERS Zackary D. Shepstone Katrina Tagget Susan L. Wessman Edwin N. Sherr Jeffery R. Taillac Evelyn Westberg Team Up for Research Sylvia Shick Maria Tartaglia Heidi A. Westhoven Ray M. Shillingford Agnes Taylor Robert Wetzel Tonya Shipman-Bennitt Ralph D. Taylor Mary A. Whatley $25,000+ $1,000+ GLASS SCIENTISTS HOLIDAY SKETCH DRIVE Andrew Shohara Thalia A. Tellez Thomas C. Whisler Sabrina Cotugno Randy Shohara Jason Tennies William White HIKE FOR MENTAL HEALTH LET’S RETHINK BPD– Internet Campaign Roy Shohara Kelsey M. Thomas Stephen Whitney Leo Walker & Tom Kennedy AIRBNB HALF MARATHON Matthew B. Shor Camilla L. Thompson Eamonn D. Wholley Houston, TX Amanda Wang $500 + Joseph Siegel Barry Thompson-Cook John A. Wiederkehr II Brooklyn, NY Rebecca A. Sikora Katherine Thorne Michael G. Wieman 6TH ANNUAL LET THE SUN SHINE RUN/WALK MEDALLION QUARTET Arnold Silver, Ph.D. Donald J. Thurston Janet Wilkinson Kathy & Curt Robbins JOHNSON & WATTS WEDDING Gary Bowie Benjamin L. Silver Nick Tindall Brent Willard Cold Spring, MN Johnson & Watts Families Austin, TX Linda Silverstein Ethel M. Toepel Andy Willett Sun Valley, ID Duncan N. Simic Gordy Tomalty Eileen Williams REITER & ULLAL WEDDING RUNNING FOR MENTAL HEALTH RESEARCH Sheldon Simkoff Caroline W. Topel Frances S. Williams Reiter & Ullal Families REMEMBER JOHNNY CHARITY EVENT Erick Martinez Jaurez Phyllis L. Simon Leanne Townsend Charles G. Williford San Francisco, CA Summer Reid Jacksonville, FL Jeff Singer Frances S. Trager Margaret Wills Orange, CA John T. Sinnott Morris Trager Peter B. Wilson $10,000+ HONEST MEDS PIN SET Steve Skinner Brett Tredinnick Richard K. Wilson TALONRO GAMING Adam J. Kurtz Connor D. Slates Christopher Trench David Windmiller CHRISSY’S WISH Internet Campaign Brooklyn, NY Benjamin E. Smith Richard Trommer Mary T. Wiragh Linda & Mario Rossi Edmund Smith Paul A. Truman Douglas Wistner Dix Hills, NY A DAY AT THE BEACH WAYGATE FOUNDATION Gary J. Smith Donald Trybula Christine Wojtusik Arlene O’Rourke Amanda Keen Lisa Smith Alexandros Tsaoussis-Maddock Sarah Wojtusik BECOMING AN IRONMAN Hampton Bays, NY Huntsville, AL Phil Smith Aaron Tuber Cheryl E. Wolfe Adrian Hunter Robert L. Smith Robert L. Tullis Ruth S. Wolfson St. George, UT RAISING AWARENESS FOR ANXIETY POWER PLANETEERS FOR BBRF Zachery R. Smith Adele C. Tursone Bernard Wortman & DEPRESSION Jee Ramos Nathan L. Solley Joseph Tursone Sarah Wright TEAM DANIEL: RUNNING FOR RECOVERY Rick Drescher Fresno, CA John T. Sommers Donald B. Tuson Prakash Yalavarthy FROM MENTAL ILLNESS New York, NY Timothy Spada Van Tuttle Andrew Yelenosky Drs. Ann & Robert Laitman MARATHON FOR MENTAL HEALTH Louis Spadaccini Barbara Ulmer Michael Yelenosky Orlando, FL & Armonk, NY DAVE GREEN MEMORIAL GOLF CLASSIC Craig Slater Joanne Spector Steven Van Lew Dorothy M. Yenco John Hagerty Long Branch, NJ Samantha Spencer Charles Varkoly Aaron S. Young $5,000+ Glen Dale, MD John A. Stapleton Elizabeth A. Varkoly Jayne Zagar TAKING STRIDES AGAINST MENTAL ILLNESS Jon Steele James W. Velasco Shervin Zahedi HORIZON GROUP PROPERTIES 120 MILES FOR LILLY–KERRY WAY ULTRA Harryet, Stuart, and Rebecca Ehrlich Joyce Stein William C. Vergos Marilyn Zalokar Gary Skoien & Connie Dyer MARATHON Wayne, NJ Kolne M. Stella The Victims of Mass Shootings Anna Zarski Rosemont, IL Theresa Majeed, Ph.D. Stephanie Allen E. Vincent Peter W. Zartman Ring of Kerry, IR GAMMA KAPPA CHAPTER FUNDRAISER Donna Stewart Keith A. Vinskofski Andrew W. Zeh BEN’S MEMORIAL MILE Ellie Bentley Pearl Stieglitz Lincoln Vivier Maria Zeier Paul Silver RUN FOR PEACE OF MIND HALF-MARATHON Williamsburg, VA Mary Stocker Joe Vories William B. Zeller Downers Grove, IL Alana Keegan Margaret Stocks-Schumacher James W. Vrooman Alexander Zenker Hartford, CT TEAM ZOEY FOR SCHIZOPHRENIA RESEARCH Evelyn Stoddard-Crane William F. Wagner, Jr. Barry L. Zimmerman TIM SPADA GOLF TOURNAMENT Emi DiStefano Amy M. Strahan Darin Wainscott Myke Furhman AMEZQUITA WEDDING Ellicott City, MD Mary J. Strub-Caulkins Kevin J. Waldmann Sherman, CT Amezquita Family Kenneth E. Stutzman Daniel F. Walker Liberty Hill, TX MAY IS MENTAL HEALTH Michael D. Sugarman Gary W. Wallace NAMI EASTSIDE SUPPORT GROUP AWARENESS MONTH Carol L. Sullivan Don Walsh Dr. Tom B. Coles RPG CROSSING FUNDRAISER Adrienne Natale Charlie Summerville Justin Z. Wang Gross Pointe Woods, MI Mark Engelhardt Quincy, MA Mary Suslovich Lei Wang Ottawa, Canada Steven C. Sutton Vivian L. Wason Jeffrey G. Sweeney Wesley Watkins MUSIC FOR MENTAL HEALTH Carol R. Swenson Kathy Watt Madhumita Parmar Jayne M. Swiderski-Fischer Mary Weber Scotch Plains, NJ Ruth Szersba Dr. Carroll Weinberg Andrew Taddy Daniel Weiss

94 ANNUAL REPORT 2016 www.bbrfoundation.org 95 EXAMPLES OF TEAM UP FUNDRAISING EVENTS

t e a m u p f o r

$10,000+ $25,000+

IRONMAN 70.3 LET THE SUN SHINE TRIATHLON RUN/WALK r e s e a r c h Saint George, UT Cold Spring, MN

Three years ago, San Francisco-based Adri- This event was created to honor the an Hunter lost his younger brother, Dylan memory of Jonathan James Robbins. Jon- at the age of 22. He suffered from OCD and athan was diagnosed with schizophrenia depression, and eventually succumbed to and depression and committed suicide drug use. To raise awareness for the perva- on April 28, 2010 at the age of 22. With the support of family, friends and community, siveness of mental illness around the world, Adrian partnered with his close friend Bri- “This world WILL be a better place because everyone can make a difference in the fight against an Litke to train for the 2016 Ironman 70.3 of Jonathan’s death; not for us who loved Triathlon. The grueling 4-month training him, but for all those other families out mental illness. resulted in an exciting finish and a gener- there who still have hope that a cure or ous donation given to the Brain & Behavior better faster-acting medicine can help Research Foundation. their loved ones.” —Kathy Robbins, Jonathan’s Mom When you raise money to support BBRF, you not only “Despite being a wonderful charming boy, my little brother Dylan never stood a chance. His fund the most innovative scientific research, you help mental disorders resulted in dangerous drug use which served as his escape from reality. alleviate suffering caused by the stigma attached Our society needs significant resources to help understand and find cures to help people to these illnesses. We are grateful to our generous free themselves from mental imprisonment. It requires innovative out-of-the box thinking, donors who support Foundation-funded grantees in which is why I partnered with BBRF.” their search for better treatments and advances in —Adrian Hunter, Dylan’s Brother brain and behavior research.

In 2016, community fundraising events raised more than $218,000.

96 ANNUAL REPORT 2016 www.bbrfoundation.org 97 Save The Date Friday, October 27, 2017 d o n o r s t o r i e s People who support the Brain & Behavior Research Foundation INTERNATIONAL impact the future of scientific achievement and moving the needle MENTAL HEALTH forward in the search for better treatments and cures for mental 29TH ANNUAL 29TH illness. While we are grateful for their generosity, we are even more appreciative of their personal belief in our mission to help alleviate RESEARCH the suffering caused by mental illness through research grants. This SYMPOSIUM meaningful connection to our work can be best seen in their stories. Keynote talk and presentations on leading research discoveries across brain The unwavering support of family and friends for those living with and behavior disorders by the Foundation’s 2017 Outstanding Achievement Prizewinners and two specially selected Young Investigator Grantees. mental illness sometimes transcends day-to-day support to become a force for many. Inspired and sometimes challenged by their loved ones, these are the stories of families who are determined to take the fight against silent, closeted, and misunderstood illnesses of the brain INTERNATIONAL beyond their own homes and toward a future where all can lead AWARDS DINNER healthy and productive lives. Celebrating the exceptional contributions of this year’s Pardes Humanitarian Prizewinner and Outstanding Achievement

30TH ANNIVERSARY Prizewinners at The Pierre.

FOR MORE INFORMATION [email protected] 646.681.4888

98 ANNUAL REPORT 2016 www.bbrfoundation.org 99 Chrissy’s Wish Fulfills a Promise to a Beloved Daughter

Hike for Mental Health is a Trek In the week following his daughter’s sui- For decades Chrissy drifted from doctor as well as research on our understanding cide, Mario Rossi discovered more than to doctor, therapist to therapist. She was of the brain. Toward Treatment 150 medical books and journals scattered hospitalized multiple times, once after a in the basement of her Queens, New York suicide attempt. Doctors placed her on var- It has been 10 years since Chrissy has At his Hike for Mental Health events, Leo treatments and eliminate the stigma,” he home. Twenty-six year-old Chrissy had ious medications for her depression, and passed away. Through the Rossi’s annual Walker sometimes has fellow hikers ap- said. He approached the Brain & Behavior been searching for answers in these books, she often found herself in a whirlwind of “Chrissy’s Wish” fundraiser, with an atten- proach him with a confession: “I have never Research Foundation with his first check scribbling notes, leaving Post-its and high- severe side effects. Sometimes the drugs dance of 300 people, Linda and Mario have told anybody this before, but I suffer from for $6,187 in 2012 when Hike for Mental lighting passages. But the answers she was would work for a while, and then stop. raised more than half a million dollars for mental illness.” Walker, a sales marketing, Health was a small grassroots organiza- looking for could not be found even in the brain and behavior research over the past and operations consultant for companies tion. Since then, it has become a nonprofit most cutting-edge research. On July 21, 2006, Chrissy went over to her nine years. The money has been donated that work with small businesses, is all too 501c3 and the Brain & Behavior Research parents’ home and stayed for an hour. entirely to the Brain & Behavior Research familiar with the stigma surrounding mental Foundation has received the majority of Her mother, Linda, sat on the living room She kissed them goodbye, and told them Foundation and its mission of funding health issues. His mother lived with schizo- all funds raised by Hike for Mental Health, floor, the books in a circle around her. She she loved them. At 10:30 that night, Linda mental health research. phrenia throughout her adult life. totaling almost $130,000. realized that Chrissy had left them a quest. called to check in. Chrissy told her that her She made a promise to her daughter that friend Dave was coming later. “Momma, “This is our cause, and one we share He believes that she could have led a fuller, “I am absolutely convinced that there is more her death would not be in vain. Linda would you have to let it go.” Those were her last with literally millions of others,” said happier life, before passing away from can- pain caused by the stigma than by the dis- do something to find the answers her words to Linda. Linda and Mario. cer 15 years ago, if her schizophrenia had ease. It’s the stigma that prevents the disease daughter was searching for. been better understood and treated. This from getting treated,” Walker said. On trails, Like Chrissy, 90 percent of those who is a big reason why he co-founded Hike for Walker often meets hikers who tell him that Chrissy was first diagnosed with clinical die by suicide experience mental illness. Mental Health in 2011 with partners Tom hiking has saved their life. “They mean that depression when she was 14 years old, Linda and Mario set up the “Chrissy’s Kennedy and Nancy Kozanecki. They dis- literally. That’s been one of the most heart- an active and athletic freshman in high Wish Memorial Fund” as a way to fulfill the covered that they all enjoyed the outdoors warming aspects of what we’ve done.” school. Since the age of six, Chrissy had promise they made to their daughter. It and had some connection to mental illness been a gifted gymnast, competing in is their hope that they will be able to help through family and friends. high school-level events even while in tear down the stigma of mental illness and elementary school. bring awareness to mental health issues, Thus was born a nonprofit with a dual mission: foster an appreciation for wilderness trails through fundraising hikes, and direct those donations towards research into the causes and cures for brain and behavior disorders. Since 2011, the organization has grown into a nationwide movement, supporting hikes from New Hampshire Leo Walker and Dr. Jeffrey Borenstein to as far west as California. Donations come in through the online sponsorship pages set up by participants. This past year alone, Hike for Mental Health has arranged more than 20 different events around the country.

Hike for Mental Health’s core team realized that if they raised money for direct care, it would help some people but “not on a very large scale and not necessarily in a lasting way,” said Walker. The group wanted to make a bigger, longer-lasting impact by “funding research that would lead to breakthroughs in our understanding of the brain From Left to Right: Joe Rossi, Diana Rossi, Linda Rossi, Angela Rossi and Mario Rossi and behaviors that would lead to better

100 ANNUAL REPORT 2016 www.bbrfoundation.org 101 KLERMAN & FREEDMAN PRIZEWINNERS GOLDMAN-RAKIC PRIZE FOR The Annual Klerman and Freedman Prizes OUTSTANDING ACHIEVEMENT IN recognize exceptional clinical and basic COGNITIVE NEUROSCIENCE research conducted by Young Investigator Earl K. Miller, Ph.D. Grantees. The prizewinners are selected Massachusetts Institute of Technology by committees of the Foundation’s Scien- tific Council. COLVIN PRIZE FOR OUTSTANDING ACHIEVE- 2 0 1 6 b r a i n MENT IN MOOD DISORDERS RESEARCH 2016 KLERMAN PRIZEWINNER: Francis J. McMahon, M.D. Katie A. McLaughlin, Ph.D. National Institute of Mental Health University of Washington Thomas G. Schulze, M.D. HONORABLE MENTIONS: Medical Center of the University of Munich & b e h a v i o r Erin C. Dunn, Sc.D., MPH Harvard Medical School and Pamela Sklar, M.D., Ph.D. Massachusetts General Hospital Icahn School of Medicine at Mount Sinai

Avram J. Holmes, Ph.D. RUANE PRIZE FOR OUTSTANDING Yale University ACHIEVEMENT IN CHILD AND ADOLESCENT r e s e a r c h PSYCHIATRIC RESEARCH 2016 FREEDMAN PRIZEWINNER: John L. R. Rubenstein, M.D., Ph.D. Kay M. Tye, Ph.D. University of California, San Francisco Massachusetts Institute of Technology THE PARDES HUMANITARIAN PRIZE HONORABLE MENTIONS: IN MENTAL HEALTH f o u n d a t i o n Kathleen Kyung Ah Cho, Ph.D. This international Prize recognizes a University of California, San Francisco physician, scientist or public citizen whose extraordinary contribution has made a Conor Liston, M.D., Ph.D. profound and lasting impact by improving Weill Cornell Medical College the lives of people suffering from mental illness and by advancing the understanding prizewinners OUTSTANDING ACHIEVEMENT of mental health. The Pardes Humanitar- AWARD PRIZEWINNERS ian Prize has been established to honor With its Outstanding Achievement individuals, who comprehensively care, Prizes, the Brain & Behavior Research teach, investigate, work and passionately Foundation recognizes outstanding re- advocate for improving the mental health search leadership and contributions of society, and who have had a powerful to mental health research. impact on reducing the pain inflicted by psychiatric illness. LIEBER PRIZE FOR OUTSTANDING ACHIEVE- MENT IN SCHIZOPHRENIA RESEARCH HONOREES: Michael F. Green, Ph.D. & Vikram Patel, Ph.D., F.Med.Sci. & Stephen R. Marder, M.D. Charles F. Reynolds III, M.D. University of California, Los Angeles HONORARY TRIBUTE: MALTZ PRIZE FOR OUTSTANDING ACHIEVE- Senator Edward M. Kennedy MENT IN SCHIZOPHRENIA RESEARCH William P. Horan, Ph.D. & Amanda McCleery, Ph.D. University of California, Los Angeles

102 ANNUAL REPORT 2016 www.bbrfoundation.org 103 2 0 1 6 f i n a n c i a l We are pleased to report on the financial position and results of the Brain & Behavior Research Foundation for 2016. We acknowledge, with great thanks and appreciation, the outstanding commitment of Foundation leadership, dedicated staff, volunteers and our donors that allow the Foundation to perform its vital work. We are indebted to the Foun- dation Scientific Council, our distinguished research leaders covering virtually every major discipline within brain and behavior science, who volunteer their expertise to select and recommend the most promising projects to fund.

s u m m a r y In 2016, contributions remained strong and bequests continued to provide major support for which we are deeply grateful to all of our supporters for their generosity. We would like to again acknowledge the extraordinary bequest from the late Oliver D. Colvin, Jr. that continues to impact the work of the Foundation. Together, all these donations further the Foundation’s mission to alleviate the suffering caused by mental illness by awarding grants that will lead to advances and breakthroughs in scientific research.

With another strong year of results, we continue to move forward with our aim of accelerating research accomplishments to help those living with mental illness to live full and productive lives. During 2016, the Foundation awarded additional NARSAD Grants to bring the total investment in mental health research to more than $360 million since inception.

We remain very appreciative and thankful for the generosity of the two family foundations who have underwritten, once again, the Foundation’s operating expenses. This allows for contributions targeted for research to go directly to funding NARSAD Grants. The financial report shown herein has been summarized from our 2016 audited financial statements. The Foundation’s complete audited financial statements and our most recent IRS Form 990 are available online at bbrfoundation.org or contact our office at 800.829.8289 for copies of the material.

104 ANNUAL REPORT 2016 www.bbrfoundation.org 105 COMBINED STATEMENT OF FINANCIAL POSITION COMBINED STATEMENT OF ACTIVITIES

YEAR ENDED DECEMBER 31, 2016 DECEMBER 31, 2016 ASSETS SUPPORT AND REVENUE

Cash and cash equivalents $8,263,754 Contributions $9,337,444

Investments, at fair value 20,579,851 Special events, net 429,584 Contributions receivable 75,121 Contribution of services 1,886,697 Pledges receivable, net 216,298 Bequests 5,047,159 Prepaid expenses and other assets 61,869 Net realized and unrealized gains on investments 893,702 Assets held in charitable remainder trusts 1,310,542 Net depreciation of assets held in charitable remainder trusts (52,927) Fixed assets, net 24,063 Dividend and interest income 514,565 Security deposits 77,110 Total Support and Revenue 18,056,224 $30,608,608

EXPENSES LIABILITIES AND NET ASSETS Program Services Liabilities Research grants and awards 11,932,235 Accounts payable and accrued expenses $161,974 Scientific advancement 2,256,076 Grants payable 18,084,922 Program support 2,814,906 Accrued compensation 83,420 Total Program Services 17,003,217 Annuities payable 737,604 Supporting Services Charitable gift annuities payable 284,323 Fundraising* 930,447 Total Liabilities 19,352,243 Administration* 1,682,736 Net Assets Total Supporting Services 2,613,183 Unrestricted 6,342,865 Total Expenses 19,616,400 Permanently restricted 4,913,500 Change in Net Assets (1,560,176) Total Net Assets 11,256,365 Net Assets, beginning of year 12,816,541 $30,608,608 Net Assets, end of year $11,256,365

*All fundraising and administrative expenses are funded by specially designated grants.

106 ANNUAL REPORT 2016 www.bbrfoundation.org 107 90 Park Avenue, 16th floor New York, NY 10016—1301 646.681.4888 | 800.829.8289 [email protected] bbrfoundation.org

Investing in Breakthroughs to Find a Cure 100% of donor contributions for research are invested in our grants leading to advances and breakthroughs in brain and behavior research. This is made possible by the generous support of two family foundations which cover our Foundation’s operating expenses.

OUR MISSION: OUR CREDENTIALS: The Brain & Behavior Research Foundation is committed Since 1987, we have awarded more than $360 million to to alleviating the suffering caused by mental illness fund more than 5,000 grants to more than 4,000 scien- by awarding grants that will lead to advances and tists around the world. breakthroughs in scientific research. OUR VISION: HOW WE DO IT: To bring the joy of living to those affected by mental The Foundation funds the most innovative ideas in illness-those who are ill and their loved ones. neuroscience and psychiatry to better understand the causes and develop new ways to treat brain and behavior disorders. These disorders include depression, bipolar disorder, schizophrenia, autism, attention-deficit hyperactivity disorder, anxiety, borderline personality disorder, chemical dependency, obsessive-compulsive disorder and post-traumatic stress disorders.