(12) Patent Application Publication (10) Pub. No.: US 2011/005250.6 A1 Abel Et Al
US 2011 0052506A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2011/005250.6 A1 Abel et al. (43) Pub. Date: Mar. 3, 2011 (54) STABLE AEROSOL TOPICAL FOAMS Publication Classification COMPRISINGA HYPOCHLORITE SALT (51) Int. Cl. (75) Inventors: Douglas Abel, Sudbury, MA (US); st 94;O CR Ronald M. Gurge, Franklin, MA ( .01) (US); Mark W. Trumbore, A6IP3L/00 (2006.01) Westford, MA (US) (52) U.S. Cl. .......................................................... 424/45 (73) Assignee: Collegium Pharmaceutical, Inc., (57) ABSTRACT Cumberland, RI (US) Described herein are compositions useful in the treatment of atopic dermatitis and other skin conditions, which composi (21) Appl. No.: 12/872,566 tions exhibit enhanced stability. The compositions contain a 1-1. hypochlorite salt, useful for its antimicrobial properties, and (22) Filed: Aug. 31, 2010 are non-irritating when applied to the skin. The compositions O O also provide enhanced moisturizing properties. The compo Related U.S. Application Data sitions can be formulated into a topical aerosol foam with (60) Provisional application No. 61/238,439, filed on Aug. inert, non-flammable propellants, such as hydrofluoroal 31, 2009. kanes, and may be used in cosmetics or pharmaceuticals. US 2011/005250.6 A1 Mar. 3, 2011 STABLE AEROSOL TOPCAL FOAMS itch associated with atopic dermatitis; however, they can COMPRISINGA HYPOCHLORITE SALT cause sleepiness and may not help in all cases of atopic dermatitis. RELATED APPLICATION 0007 For mild cases of atopic dermatitis, an over-the counterformulation of coal taris often used. Coaltar has long 0001. This application claims benefit under 35 U.S.C. 119 been a treatment for a variety of skin conditions.
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