CURRICULUM VITAE
Personal Information Name Shengbo Cao Gender Male Position Title Professor, Vice Dean Working Department College of Veterinary Medicine Email [email protected] Shizishan Street#1, College of Veterinary Medicine, Address Huazhong Agricultural University, Wuhan,430070,Hubei, P.R.China Tel 0086-27-8761-8028 Fax 0086-27-8728-2608 Research Interest
1) Development of animal infectious diseases vaccine and diagnosis methods 2) Interaction between Japanese Encephalitis Virus and host cells
Professional Memberships 1) Guest editor: Mediators of Inflammation“special issue—inflammation in Diseases: Mechanisms to Therapies 2) Editor in board: The Scientific World Journal 3) Editor in board: SRL Virology & Infectious Diseases Other Roles
Reviewer: Review in Medicine Virology、Molecular Medicine、Scientific reports、Antiviral Research、Vaccine、Future Virology、Virus Research
Education & Working Experience
Education
School Name Huazhong Agricultural University Address Wuhan, Hubei, 430070, P.R China Major Veterinary Medicine Degree/Diploma Doctor From: Month/Year To: Month/Year 09/2002 to 06/2005 School Name Huazhong Agricultural University Address Wuhan, Hubei, 430070, P.R China Major Veterinary Medicine Degree/Diploma Master From: Month/Year To: Month/Year 09/1999 to 06/2002 School Name Huazhong Agricultural University Address Wuhan, Hubei, 430070, P.R China Major Veterinary Medicine Degree/Diploma Bachelor From: Month/Year To: Month/Year 09/1999 to 06/2002
Work Experience
Employer Huazhong Agricultural University Employer Address Wuhan, Hubei, 430070, P.R China From: Month/Year To: Month/Year 01/2012 to now Position Title Professor Employer Huazhong Agricultural University Employer Address Wuhan, Hubei, 430070, P.R China From: Month/Year To: Month/Year 05/2008 to 12/2011 Position Title Associate Professor Employer University of Hawaii at Manoa Employer Address 1960 East-west Road, Honolulu, HI From(Month/Year To: Month/Year) 10/2006-05/2008 Supervisor Yuanan Lu Position Title Junior Researcher Employer Huazhong Agricultural University Employer Address Wuhan, Hubei, 430070, P.R China From: Month/Year To: Month/Year 07/2003 to 10/2006 Position Title Lecturer Employer Huazhong Agricultural University Employer Address Wuhan, Hubei, 430070, P.R China From: Month/Year To: Month/Year 07/1998 to 06/2003 Position Title assistant
Publications (* Corresponding author) [1] Usama Ashraf , Bibo Zhu, Jing Ye, Shengfeng Wan, Yanru Nie, Zheng Chen, Xiaodong Duan , Hao Zhang, Huanchun Chen, Shengbo Cao*. microRNA-19b-3p modulates Japanese encephalitis virus-mediated inflammation via targeting RNF11.Journal of Virology.2016, pii: JVI.02586-15. [2] Zheng Chen, Jing Ye, Yunchuan Li, Usama Ashraf, Shengfeng Wan, Ali Zohaib,Yunfeng Song, Huanchun Chen, Shengbo Cao*. miR-33a-5p modulates Japanese Encephalitis Virus Replication by targeting Eukaryotic Translation Elongation Factor 1A1. Journal of Virology.2016, pii: JVI.03242-15 . [3] Bibo Zhu, Jing Ye, Usama Ashraf, Yunchuan Li Huanchun Chen, Yunfeng Song and Shengbo Cao*. Transcriptional regulation of miR-15b by c-Rel and CREB in Japanese encephalitis virus infection. Scientific Reports.2016, 6:22581. [4] Hao Zhang, Jun Sun,Jing Ye, Usama Ashraf, Zheng Chen,Bibo Zhu,Wen He, Qiuping Xu, Yanming Wei,Huanchun Chen, Zhen F. Fu, Rong Liu*,Shengbo Cao*. Quantitative Label-Free Phosphoproteomics Reveals Differentially RegulatedProtein Phosphorylation Involved in West Nile Virus–Induced Host Inflammatory Response. Journal of proteome research. 2015, 4;14(12):5157-68. [5] Ali Zohaib, Adeel Sarfraz, Qari Muhammad Kaleem, Jing Ye, Mudassar Niaz Mugha, Muhammad Tariq Navid, Faheem Ahmed Khan, Xiaodong Duan, Bibo Zhu, Shengfeng Wan and Shengbo Cao*.The Yin and Yang of Antiviral Innate Immunity in Central Nervous System. Current Pharmaceutical Desig.2016,22(46) :648-55. [6] Bibo Zhu, Jing Ye, Yanru Nie, Usama Ashraf,, Ali Zohaib, Xiaodong Duan, Zhen F. Fu, Yunfeng Song, Huanchun Chen, Shengbo Cao *.MicroRNA-15b Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF125. Journal of Immunology. 2015,195(5):2251-62. [7] Lu Z, Cao S, Zhou H, Hua L, Zhang S, Cao J. Mechanism of Arctigenin-Induced Specific Cytotoxicity against Human Hepatocellular Carcinoma Cell Lines: Hep G2 and SMMC7721. PLoS One. 2015, 1;10(5):e0125727. [8] Qian Dong, Qiuping Xu, Xindi Ruan, Shaomei Huang, Shengbo Cao*. Monoclonal Antibodies Against NS2B of Japanese Encephalitis Virus. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 2015,34(2):96-100. [9] Fang Li#, Yueyun Wang#, Lan Yu#, Shengbo Cao, Ke Wang, Jiaolong Yuan, Chong Wang, Kunlun Wang, Min Cui*, Zhen F. Fu. Viral Infection of the Central Nervous System and Neuroinflammation Precede Blood-Brain Barrier Disruption during Japanese Encephalitis Virus Infection. Journal of Virology. 2015, 15;89(10):5602-14. [10] Ali Zohaib#, Xiaodong Duan#, Bibo Zhu, Jing Ye, ShengfengWan, Huanchun Chen, Xueqin Liu*, Shengbo Cao*. The Role of Ubiquitination in Regulation of Innate Immune Signaling. Current Issues in Molecular Biology. 2015,30;18:1-10 [11] Usama Ashraf, Jing Ye, Xindi Ruan, Shengfeng Wan, Bibo Zhu, and Shengbo Cao* Usutu virus: an emerging flavivirus in Europe. Viruses-Basel. 2015,19;7(1):219-38. [12] Yang Yang#, Ying Huang#, Clement W. Gnanadurai#, Shengbo Cao, Xueqin Liu, Min Cui*, and Zhen F. Fu*.The inability of wild-type rabies virus to activate dendritic cells is dependent on the glycoprotein and correlates with its low level of the de novo-synthesized leader RNA. Journal of Virology. 2015,89(4):2157-69. [13] Yumeng Zhang#, Huan Li#, Guiqing Peng, Yong Zhang, Xiao Gao, Shaobo Xiao, Shengbo Cao, Huanchun Chen, Yunfeng Song. Mutational analysis of the functional sites in porcine reproductive and respiratory syndrome virus nonstructural protein 10. Journal of General Virology. 2015,96(Pt 3):547-52. [14] Xiaodong Duan, Ali Zohaib, Yunchun Li, Bibo Zhu, Jing Ye, Shengfeng Wan, Qiuping Xu, Yunfeng Song, Huanchun Chen, Shengbo Cao*. miR-206 modulates lipopolysaccharide-mediated inflammatory cytokine production in human astrocytes. Cellular Signalling.2015, 27 : 61-68. [15] Ali Zohaib, Muhammad Saqib**, Muhammad Hammad Hussain, Steeve Lowenski, Sylvie Lecollinet, Cécile Beck, Awais-ur-Rehman Sial, M. Nadeem Asi, M. Khalid Mansoor, Muhammad Saqalein, Khurram Ashfaq, Muhammad Saleem, Ghulam Muhammad and Shengbo Cao*. High Prevalence of West Nile Virus in Equines from the two provinces of Pakistan. Epidemiology and Infection.2015, 143 （9）1931-1935
[16] Rong Jiang#, Jing Ye#, Bibo Zhu, Yunfeng Song, Huanchun Chen,Shengbo Cao*.Roles of TLR3 and RIG-I in Mediating the Inflammatory Response in Mouse Microglia Following Japanese Encephalitis Virus Infection. Journal of Immunology Research. 2014,787023. [17] Jing Ye#, Rong Jiang#, Min Cui, Bibo Zhu, Leqiang Sun, Yueyun Wang, Ali Zohaib, Qian Dong, Xindi Ruan, Yunfeng Song, Wen He, Huanchun Chen, Shengbo Cao*. Etanercept reduces neuroinflammation and lethality in mouse model of Japanese encephalitis. Journal of infectious diseases.2014, 15;210(6):875-89. [18] XiaoDan Li#, XiaoFeng Li#, HanQing Ye, ChengLin Deng, Qing Ye, Chao Shan, BaoDi Shang, LinLin Xu, ShiHua Li, Shengbo Cao, Zhiming Yuan, PeiYong Shi, ChengFeng Qin*, and Bo Zhang*. Recovery of a chemically synthesized Japanese encephalitis virus revealed two critical adaptive mutations in NS2B and NS4A. Journal of General Virology 2014, 95(4):806-15. [19] Jin’e Fang#, Leqiang Sun#, Guiqing Peng, Jia Xu, Rui Zhou, Shengbo Cao, Huanchun Chen, Yunfeng Song*. Identification of Three Antiviral Inhibitors against Japanese Encephalitis Virus from Library of Pharmacologically Active Compounds 1280. PLoS ONE, 2013, 8(11): e78425. [20] Yang Yang#, Ali Zohaib#, Gong Chen, Jing Ye, Shengbo Cao*. DC-SIGN Increase Japanese Encephalitis Virus Infection. Pakestan Vet J.2013, 33(4): 408-412. [21] Jing Ye, Zheng Chen, Bo Zhang, Huan Miu, Ali Zohaib, Qiuping Xu, Huanchun Chen*, Shengbo Cao *. Heat shock protein 70 is associated with replicase complex of Japanese encephalitis virus and positively regulates viral genome replication. Plos One,2013, 8(9):e75188.
[22] Jin’e Fang, Huan Li, Guiqing Peng, Shengbo Cao, F. Fu Zhen, Huanchun Chen, Yunfeng Song∗.
Methods for detecting ATP hydrolysis and nucleic acid unwinding of Japanese encephalitis virus NS3 helicase. Journal of Virological Methods. 2013;194(1-2):33-8. [23] Zai J, Mei L, Wang C, Cao S, Fu ZF, Chen H, Song Y*. N-glycosylation of the premembrane protein of Japanese encephalitis virus is critical for folding of the envelope protein and assembly of virus-like particles. Acta Virologica. 2013;57(1):27-33. [24] Rui Jin, Wandi Zhu, Shengbo Cao, Rui Chen, Hui Jin, Yang Liu, Shaobo Wang, Wei Wang* and Gengfu Xiao* Japanese encephalitis virus activates autophagy as a viral immune evasion strategy. PLoS One. 2013;8(1):e52909.4
[25] Xindi Ruan ， Shaomei Huang, Lin Shao, Jing Ye, Zheng Chen, Huanchun Chen and Shengbo
Cao*.Monoclonal antibodies against NS4B protein of Japanese encephalitis virus. Monoclonal Antibodies in Immunodiagnosis and Immunotherapy.2013,32(6):382-385. [26] Jing Ye, Bibo Zhu, Zhen F. Fu, Huanchun Chen, Shengbo Cao*. Immune evasion strategies of flaviviruses. Vaccine, 2013,31(3) : 461–471. [27] Bibo Zhu, Jing Ye, Ping Lu, Rong Jiang, Xiaohong Yang, Zhen F Fu, Huanchun Chen, Shengbo Cao*. Induction of Antigen-Specific Immune Responses in Mice by Recombinant Baculovirus Expressing Premembrane and Envelope Proteins of West Nile Virus. Virology Journal. 2012,9:132. [28] Zheng Chen, Lin Shao, Jing Ye, Yongmao Li, Shaomei Huang, Huanchun Chen and Shengbo Cao*. Generation and characterization of the monoclonal antibodies against NS3 and NS5 proteins of Japanese encephalitis virus. Hybridoma. 2012,31(2):137-41. [29] Li Mei#, Peng Wu#, Jing Ye, Lin Shao, Shaomei Huang,Yaoming Li, Xiaohong Yang, Huanchun Chen and Shengbo Cao*. Development and Application of an Antigen Capture ELISA Assay for Diagnosis of
Japanese encephalitis Virus in Swine，Human and Mosquito. Virology Journal. 2012, 9:4.
[30] Xiaohong Yang, Lidan Hou, Jing Ye, Qigai He, Shengbo Cao*. Detection of Porcine Circovirus Type 2 in Mosquitoes from Pig Farms by PCR. Pakestan Vet J.2012,32(1):134-135. [31] Fang Li, Li Mei, Yaoming Li, Kaihong Zhao, Huanchen Chen, Peng Wu, Yonggang Hu*, Shengbo Cao* Facile fabrication of magnetic gold electrode for magnetic beads-based electrochemical immunoassay:
Application to the diagnosis of Japanese encephalitis virus. Biosens Bioelectron. 2011，26: 4253–4256.
[32] Shengbo Cao#, Chengxiang Wu#, Yongbo Yang, Lynn F Sniderhan, Sanjay B Maggirwar, Stephen Dewhurst, Yuanan Lu* . Lentiviral vector-mediated stable expression of sTNFR-Fc in human macrophage and neuronal cells as a potential therapy for neuroAIDS. Journal of Neuroinflammation. 2011, 8:48. [33] Yang Yang#, Jing Ye#, Xiaohong Yang, Rong Jiang, Huanchun Chen, Shengbo Cao*. Japanese encephalitis virus infection induces changes of mRNA profile of mouse spleen and brain. Virology Journal 2011, 8:80. [34] Yaoming Li#, Jing Ye#, Xiaohong Yang, Min Xu, Long Chen, Xueqin Liu, Huanchun Chen, Shengbo Cao*. Infection of mouse bone marrow-derived dendritic cells by live attenuated Japanese encephalitis virus induces cells maturation and triggers T cells activation. Vaccine, 2011, 29:855-862.
[35] Shengbo Cao#， Yaomin Li#, Jing Ye, Xiaohong Yang, Long Chen, Xueqin Liu, Huanchun Chen*.
Japanese Encephalitic Virus wild strain infection suppresses dendritic cells maturation and function, and causes the expansion of regulatory T cells. Virology Journal, 2011, 26; 8(1):39. [36] Fengtao Huang#, Shengbo Cao#, Xiaoxian Cui, Chuanxi Xiong, Min Wang, Yuanan Lu, Weimin Wang, Jing Ye, Xueqin Liu*. Efficient gene delivery into fish cells by an improved recombinant baculovirus.
Journal of Virological Methods. 2011，173(2):294-9.
[37] Yaoming Li#,Lidan Hou#, Jing Ye, Xueqin Liu, Hanbing Dan, Meilin Jin, Huanchun Chen, Shengbo Cao*. Development of a convenient immunochromatographic strip for the diagnosis of infection with Japanese encephalitis virus in swine. Journal of Virological Methods. 2010, 168(1-2):51-6. [38] Courtney Cox, Shengbo Cao and Yuanan Lu*. Enhanced detection and study of murine norovirus-1 using a more efficient microglial cell line. Virology Journal. 2009, 6:196. [39] Yaoming Li, Min Xu, Long Chen, Jinghui Zhu, Jing Ye, Xueqin Liu,Yanfang Sun, Huanchun Chen, Shengbo Cao∗ Evaluation of Murine Bone Marrow-Derived Dendritic cells Loaded with Inactivated
Virus as a Vaccine against Japanese Encephalitis Virus. Vaccine, 2009, 27(43): 6004-6010. [40] Yaoming Li#, Jing Ye#, Shengbo Cao*, Shaobo Xiao, Qian Zhao, Xueqin Liu, Meilin Jin Huanchun Chen. Immunization with pseudotype baculovirus expressing envelope protein of Japanese encephalitis virus elicits protective immunity in mice. Journal of Gene Medicine 2009, 11(1):57-65. [41] Cao, S.B, S. Maggirwar, Huanyu Dou at el. Lentivirus vector mediated transduction and stable expression of a soluble, decoy tumor necrosis factor alpha receptor in immortalized microglial cell lines. J. Neurovirology. 2007, 13(S1):71 [42] Minxuan Sun, Xueqin Liu, Shengbo Cao*, Qigai He, Rui Zhou, Jing Ye, Yaoming Li, Huanchun Chen. Inhibition of porcine circovirus type 1 and type 2 production in PK-15 cells by small interfering RNAs targeting the Rep gene. Veterinary Microbiology. 2007, 20; 123(1-3):203-209. [43] Yunfeng Song, Meilin Jin*, Songlin Zhang, Xiaojuan Xu, Shaobo Xiao, Shengbo Cao, Huanchun Chen. Generation and immunogenicity of a recombinant pseudorabies virus expressing cap protein of porcine circovirus type 2. Veterinary Microbiology, 2007, 31; 119(2-4):97-104.
[44] Hongbo Zhou, Meilin Jin∗, Zhengjun Yu, Xiaojuan Xu, Yaping Peng, Haiya Wu, Jinlin Liu, Hu Liu,
Shengbo Cao, Huanchun Chen*. Effective small interfering RNAs targeting matrix and nucleocapsid protein gene inhibit influenza A virus replication in cells and mice. Antiviral Research. 2007, 76(2):186-193. [45] Xueqin Liu, Shengbo Cao*, Rui Zhou, Gaoyuan Xu, Shaobo Xiao, Ying Yang, Minxuan Sun, Yaoming Li, Huanchun Chen*. Inhibition of Japanese encephalitis virus NS1 protein expression in cell by small interfering RNAs. Virus Genes. 2006, 33(1):69-75. [46] Chunmei Ju, Huiying Fan, Yadi Tan, Zhengfei Liu, Xin Xi, Shengbo Cao, Bin Wu, Huanchun Chen*. Immunogenicity of a recombinant pseudorabies virus expressing ORF1-ORF2 fusion protein of porcine circovirus type 2. Veterinary Microbiology. 2005, 30; 109(3-4):179-90. [47] Shengbo Cao, Huanchun. Chen*, Junlong Zhao Jianqiang Lu, Shaobo Xiao, Meilin Jin, Aizhen Guo, Bin Wu, Qigai He. Detection of Porcine Circovirus Type 2, Porcine Parvovirus and Porcine Pseudorabies Virus from Pigs with Postweaning Multisystemic Wasting Syndrome by Multiplex PCR. Veterinary Research Communications. 2005, 29(3): 263-269.
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