DOCSLIB.ORG

Assessment Report on Urtica Dioica L., Urtica Urens L., Folium Based on Article 10A of Directive 2001/83/EC As Amended (Well-Established Use)

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Assessment Report on Urtica Dioica L., Urtica Urens L., Folium Based on Article 10A of Directive 2001/83/EC As Amended (Well-Established Use) 14 January 2010 EMA/HMPC/508013/2007 Committee on Herbal Medicinal Products (HMPC) Assessment report on Urtica dioica L., Urtica urens L., folium Based on Article 10a of Directive 2001/83/EC as amended (well-established use) Based on Article 16d(1), Article 16f and Article 16h of Directive 2001/83/EC as amended (traditional use) Final Herbal substance(s) (binomial scientific name of Whole or cut dried leaves of Urtica dioica L., the plant, including plant part) Urtica urens L., or a mixture of the 2 species Herbal preparation(s) - comminuted herbal substance - liquid extracts - dry aqueous and hydro-ethanolic extracts Pharmaceutical forms Herbal substance or herbal preparation in solid or liquid dosage forms for oral and external uses, or as an herbal tea for oral use Rapporteur Dr. Susanna Biró-Sándor Assessor(s) 7 Westferry Circus ● Canary Wharf ● London E14 4HB ● United Kingdom Telephone +44 (0)20 7418 8400 Facsimile +44 (0)20 7523 7051 E-mail [email protected] Website www.ema.europa.eu An agency of the European Union © European Medicines Agency, 2011. Reproduction is authorised provided the source is acknowledged. Table of contents Table of contents ...................................................................................................................2 1. Introduction.......................................................................................................................7 1.1. Description of the herbal substance(s), herbal preparation(s) or combinations thereof .7 1.2. Information on period of medicinal use in the Community regarding the specified indication ................................................................................................................ 8 1.3. Type of tradition, where relevant........................................................................ 10 1.4. Evidence regarding the indication/traditional use .................................................. 10 1.5. Evidence regarding the specified posology ........................................................... 11 1.6. Evidence regarding the route of administration..................................................... 13 1.7. Evidence regarding the duration of use................................................................ 13 1.8. Assessor’s overall conclusion on the traditional medicinal use ................................. 13 2. NON-CLINICAL DATA .......................................................................................................13 2.1. Pharmacology.................................................................................................. 13 2.1.1. Overview of available data regarding the herbal substance(s), herbal preparation(s) and relevant constituents thereof.............................................................................. 13 2.1.2. Assessor’s overall conclusions on pharmacology................................................. 20 2.2. Pharmacokinetics ............................................................................................. 21 2.2.1. Overview of available data regarding the herbal substance(s), herbal preparation(s) and relevant constituents thereof.............................................................................. 21 2.2.2. Assessor’s overall conclusions on pharmacokinetics ............................................ 21 2.3. Toxicology....................................................................................................... 21 2.3.1. Overview of available data regarding the herbal substance(s)/herbal preparation(s) and constituents thereof .......................................................................................... 21 2.3.2. Assessor’s overall conclusions on toxicology ...................................................... 22 3. CLINICAL DATA................................................................................................................22 3.1. Clinical Pharmacology ....................................................................................... 22 3.1.1. Pharmacodynamics........................................................................................ 22 3.1.1.1. Overview of available data regarding the herbal substance(s)/herbal preparation(s) including data on constituents with known therapeutic activity. ..................................... 22 3.1.1.2. Assessor’s overall conclusions on pharmacodynamics....................................... 22 3.1.2. Pharmacokinetics .......................................................................................... 22 3.1.2.1. Overview of available data regarding the herbal substance(s)/herbal preparation(s) including data on constituents with known therapeutic activity. ..................................... 22 3.1.2.2. Assessor’s overall conclusions on pharmacokinetics ......................................... 22 3.2. Clinical Efficacy ................................................................................................ 22 3.2.1. Dose response studies.................................................................................... 22 3.2.2. Clinical studies (case studies and clinical trials).................................................. 23 3.2.3. Clinical studies in special populations (e.g. elderly and children)........................... 26 3.2.4. Assessor’s overall conclusions on clinical efficacy ............................................... 26 3.3. Clinical Safety/Pharmacovigilance....................................................................... 26 3.3.1. Patient exposure ........................................................................................... 26 3.3.2. Adverse events ............................................................................................. 26 3.3.3. Serious adverse events and deaths .................................................................. 27 3.3.4. Laboratory findings........................................................................................ 27 3.3.5. Safety in special populations and situations....................................................... 27 Assessment report on Urtica dioica L., Urtica urens L., folium EMA/HMPC/508013/2007 Page 2/29 3.3.5.1. Intrinsic (including elderly and children) /extrinsic factors................................. 27 3.3.5.2. Contra indications (hypersensitivity and allergic potential to be both covered) ..... 27 3.3.5.3. Warning .................................................................................................... 27 3.3.5.4. Drug interactions ........................................................................................ 28 3.3.5.5. Use in pregnancy and lactation ..................................................................... 28 3.3.5.6. Overdose................................................................................................... 28 3.3.5.7. Drug abuse................................................................................................ 28 3.3.5.8. Withdrawal and rebound.............................................................................. 28 3.3.5.9. Effects on ability to drive or operate machinery or impairment of mental ability ... 28 3.3.6. Assessor’s overall conclusions on clinical safety ................................................. 28 4. ASSESSOR’S OVERALL CONCLUSIONS ..............................................................................29 Assessment report on Urtica dioica L., Urtica urens L., folium EMA/HMPC/508013/2007 Page 3/29 Regulatory status overview1 Member State Regulatory Status Comments2 Austria MA TRAD Other TRAD Other Specify: Belgium MA TRAD Other TRAD Other Specify: Bulgaria MA TRAD Other TRAD Other Specify: Cyprus MA TRAD Other TRAD Other Specify: Czech Republic MA TRAD Other TRAD Other Specify: Denmark MA TRAD Other TRAD Other Specify: Estonia MA TRAD Other TRAD Other Specify: No medicinal products Finland MA TRAD Other TRAD Other Specify: In combination France MA TRAD Other TRAD Other Specify: Germany 20 MA 1TRAD Other TRAD Other Specify: + In combination Greece MA TRAD Other TRAD Other Specify: Hungary MA TRAD Other TRAD Other Specify: In combination Iceland MA TRAD Other TRAD Other Specify: Ireland MA TRAD Other TRAD Other Specify: No medicinal products Italy MA TRAD Other TRAD Other Specify: No medicinal products only food- supplements Latvia MA 1 TRAD Other TRAD Other Specify: Liechtenstein MA TRAD Other TRAD Other Specify: Lithuania MA TRAD Other TRAD Other Specify: Luxemburg MA TRAD Other TRAD Other Specify: Malta MA TRAD Other TRAD Other Specify: The Netherlands MA TRAD Other TRAD Other Specify: Norway MA TRAD Other TRAD Other Specify: No medicinal products only food- supplements Poland MA TRAD Other TRAD Other Specify: Portugal MA TRAD Other TRAD Other Specify: No medicinal products Romania MA TRAD Other TRAD Other Specify: Slovak Republic MA TRAD Other TRAD Other Specify: Slovenia MA TRAD Other TRAD Other Specify: Spain MA TRAD Other TRAD Other Specify: Sweden MA TRAD Other TRAD Other Specify: United Kingdom MA TRAD Other TRAD Other Specify: MA: Marketing Authorisation; TRAD: Traditional Use Registration; Other TRAD: Other national Traditional systems of registration; Other: If known, it should be specified or otherwise add ’Not Known’ 1 This regulatory overview is not legally binding and does not necessarily reflect the legal status of the products in the MSs concerned. 2 Not mandatory field Assessment report on Urtica dioica L., Urtica urens L., folium EMA/HMPC/508013/2007 Page 4/29 Products
Load more

Recommended publications
  • FLORA from FĂRĂGĂU AREA (MUREŞ COUNTY) AS POTENTIAL SOURCE of MEDICINAL PLANTS Silvia OROIAN1*, Mihaela SĂMĂRGHIŢAN2
    ISSN: 2601 – 6141, ISSN-L: 2601 – 6141 Acta Biologica Marisiensis 2018, 1(1): 60-70 ORIGINAL PAPER FLORA FROM FĂRĂGĂU AREA (MUREŞ COUNTY) AS POTENTIAL SOURCE OF MEDICINAL PLANTS Silvia OROIAN1*, Mihaela SĂMĂRGHIŢAN2 1Department of Pharmaceutical Botany, University of Medicine and Pharmacy of Tîrgu Mureş, Romania 2Mureş County Museum, Department of Natural Sciences, Tîrgu Mureş, Romania *Correspondence: Silvia OROIAN [email protected] Received: 2 July 2018; Accepted: 9 July 2018; Published: 15 July 2018 Abstract The aim of this study was to identify a potential source of medicinal plant from Transylvanian Plain. Also, the paper provides information about the hayfields floral richness, a great scientific value for Romania and Europe. The study of the flora was carried out in several stages: 2005-2008, 2013, 2017-2018. In the studied area, 397 taxa were identified, distributed in 82 families with therapeutic potential, represented by 164 medical taxa, 37 of them being in the European Pharmacopoeia 8.5. The study reveals that most plants contain: volatile oils (13.41%), tannins (12.19%), flavonoids (9.75%), mucilages (8.53%) etc. This plants can be used in the treatment of various human disorders: disorders of the digestive system, respiratory system, skin disorders, muscular and skeletal systems, genitourinary system, in gynaecological disorders, cardiovascular, and central nervous sistem disorders. In the study plants protected by law at European and national level were identified: Echium maculatum, Cephalaria radiata, Crambe tataria, Narcissus poeticus ssp. radiiflorus, Salvia nutans, Iris aphylla, Orchis morio, Orchis tridentata, Adonis vernalis, Dictamnus albus, Hammarbya paludosa etc. Keywords: Fărăgău, medicinal plants, human disease, Mureş County 1.
    [Show full text]
  • Urtica Dioica Stinging Nettle
    TREATMENT OPTIONS from the book Weed Control in Natural Areas in the Western United States This does not constitute a formal recommendation. When using herbicides always read the label, and when in doubt consult your farm advisor or county agent. This is an excerpt from the book Weed Control in Natural Areas in the Western United States and is available wholesale through the UC Weed Research & Information Center (wric.ucdavis.edu) or retail through the Western Society of Weed Science (wsweedscience.org) or the California Invasive Species Council (cal-ipc.org). Urtica dioica Stinging nettle Family: Urticaceae (nettle) NON-CHEMICAL CONTROL Cultural: grazing P not readily grazed by livestock Cultural: prescribed burning P below ground structures not affected Mechanical: mowing and cutting P regrows rapidly if mowed early in the growing season Mechanical: tillage P─F likely requires repeated tillage for several years Mechanical: grubbing, digging or hand P─F extensive rhizomes and stinging hairs make hand pulling pulling difficult CHEMICAL CONTROL The following specific use information is based on published papers and reports by researchers and land managers. Other trade names may be available, and other compounds also are labeled for this weed. Directions for use may vary between brands; see label before use. 2,4-D E Imazapic NIA Aminocyclopyrachlor + chlorsulfuron NIA Imazapyr G Aminopyralid E Metsulfuron NIA Chlorsulfuron NIA Paraquat P Clopyralid P Picloram E Dicamba E Rimsulfuron NIA Glyphosate E Sulfometuron NIA Hexazinone NIA Sulfosulfuron NIA Triclopyr E E = Excellent control, generally better than 95% * = Likely based on results of observations of G = Good control, 80-95% related species FLW = flowering F = Fair control, 50-80% NIA = No information available P = Poor control, below 50% Fa = Fall Control includes effects within the season of treatment.
    [Show full text]
  • Nettles and the Romanian Traditions
    Nettle ( Urtica dioica ) – its role and its importance in the life of the Romanian people and in popular traditions A. Stroia, C.Cace, C.Costea, L. Libardea There isn’t a single person in Romania – from a small child to an 80 year old person, who, when asked: • „What is the nettle?”, or • „What is the nettle traditionally used for in Romania? Not to be able to offer a perfectly documented answer. But what would you say if the interlocutor you are asking these questions would answer: „When I hear the word nettle, it takes me back to my childhood, to the renowned “Nettle soup”, to the renowned “Mashed nettles”, “Nettles with garlic”, to the “pleasant, refined and special taste of the traditional Romanian dishes I have known as a child!” The nettle is a very well known plant in Romania, because it is used in the cuisine. For this reason, few think about its healing properties, to the fact that it can contribute to a better health. Its name in English, “nettle”, comes from the Dutch word “netel”, which means “needle”, due to the fact that upon touching, when the plant is young, it stings. In spite of this, nettles that are cooked or used as infusion no longer sting and have a pleasant taste. In Romania, as in the whole of Europe, North of Africa, Asia and North America, the nettle (Urtica dioica) is spread in uncultivated lands, in the plains, hillsides or mountains, on the edges of forests or roads, at the base of trees etc, being one of the many species of “spontaneous flora”.
    [Show full text]
  • Native Stinging Nettle (Urtica Dioica
    OATAO is an open access repository that collects the work of Toulouse researchers and makes it freely available over the web where possible This is an author’s version published in: http://oatao.univ-toulouse.fr/25522 Official URL: https://doi.org/10.1016/j.indcrop.2019.111997 To cite this version: Jeannin, Thomas and Yung, Loïc and Evon, Philippe and Labonne, Laurent and Ouagne, Pierre and Lecourt, Michael and Cazaux, David and Chalot, Michel and Placet, Vincent Native stinging nettle (Urtica dioica L.) growing spontaneously under short rotation coppice for phytomanagement of trace element contaminated soils: Fibre yield, processability and quality. (2020) Industrial Crops and Products, 145. 1119997. ISSN 0926-6690 Any correspondence concerning this service should be sent to the repository administrator: [email protected] Native stinging nettle ( Urtica dioica L.) growing spontaneously under short rotation coppice forphytomanagement of trace element contaminated soils: Fibre yield, processability and quality 3 b C C d Thomas Jeannin , Loïc Yung , Philippe Evon , Laurent Labonne , Pierre Ouagne , Michael Lecourte, David Cazamr, Michel Chalotb, Vincent Placet'•'" • PEMTO-STlnsdlutt, UPC/CNRS!ENSMM/UTBM, Uni1<ersitiBo,rgogne Promhe.-Comti, Besançon, Prome b LaborotOin Chrono-Environnement, UMR CNRS/UPC, UniversitiBowwgne Pranche-Comli, Montbéliard, Prome • LaboratOire de ChimieAi,oo-lndustrlelle (LCA), INP-ENSIACET, Toulouse, France • LaborotOire Géniede Production (U::P), Universitide Toulouse-ENIT, Tarbes, Prome •
    [Show full text]
  • Regulation of Urtica Dioica L. on Grasslands Vozár Ľ., Jančovič J
    Regulation of Urtica dioica L. on grasslands Vozár Ľ., Jančovič J. and Bačová S. Slovak Agricultural University in Nitra, Faculty of Agrobiology and Food Resources, Department of Grassland Ecosystems and Forage Crops, Nitra, Slovakia E-mail: [email protected] Abstract We studied some possibilities for the biological and mechanical control of the ground cover of Galio-Urticetea Passarge ex Kopecký 1969, with the association of Urtica dioica L., in a place which belongs to the village of Chvojnica in the Strážov Hills in the middle of Slovakia. The place was used as a corral for cattle in the past. Cattle had a great influence on the eutrophication of the soil. The floristic composition changed there. We examined 4 variants in our experiment: 1st – control, without cutting; 2nd – cutting every 5th week with biomass being taken away; 3rd – cutting every 5th week with mulch- ing; 4th –Dactylis glomerata L. and Trifolium repens L. reseeding, cutting four times a year. According to the five-year results of the different types of regulation it seems that the best way of regulation is reseeding with the strong competitive species Dactylis glomerata L. and Trifolium repens L. Keywords: regulation of weed infestation, Urtica dioica L., stand eutrophication, corral for cattle Introduction Livestock numbers have decreased to 1/3 of their original level in Slovakia since the year 1989 (Green Report, 2007). The area of grassland utilisation has been reduced. Inaccessible areas have been abandoned and degraded and have become covered by weeds. These stands have low or toxic forage value and these weeds also have negative influences on the en- vironment and formation of the countryside.
    [Show full text]
  • Impatiens Glandulifera
    NOBANIS – Invasive Alien Species Fact Sheet Impatiens glandulifera Author of this fact sheet: Harry Helmisaari, SYKE (Finnish Environment Institute), P.O. Box 140, FIN-00251 Helsinki, Finland, Phone + 358 20 490 2748, E-mail: [email protected] Bibliographical reference – how to cite this fact sheet: Helmisaari, H. (2010): NOBANIS – Invasive Alien Species Fact Sheet – Impatiens glandulifera. – From: Online Database of the European Network on Invasive Alien Species – NOBANIS www.nobanis.org, Date of access x/x/201x. Species description Scientific name: Impatiens glandulifera Royle (Balsaminaceae). Synonyms: Impatiens roylei Walpers. Common names: Himalayan balsam, Indian balsam, Policeman's Helmet (GB), Drüsiges Springkraut, Indisches Springkraut (DE), kæmpe-balsamin (DK), verev lemmalts (EE), jättipalsami (FI), risalísa (IS), bitinė sprigė (LT), puķu sprigane (LV), Reuzenbalsemien (NL), kjempespringfrø (NO), Niecierpek gruczolowaty, Niecierpek himalajski (PL), недотрога железконосная (RU), jättebalsamin (SE). Fig. 1 and 2. Impatiens glandulifera in an Alnus stand in Helsinki, Finland, and close-up of the seed capsules, photos by Terhi Ryttäri and Harry Helmisaari. Fig. 3 and 4. White and red flowers of Impatiens glandulifera, photos by Harry Helmisaari. Species identification Impatiens glandulifera is a tall annual with a smooth, usually hollow and jointed stem, which is easily broken (figs. 1-4). The stem can reach a height of 3 m and its diameter can be up to several centimetres. The leaves are opposite or in whorls of 3, glabrous, lanceolate to elliptical, 5-18 cm long and 2.5-7 cm wide. The inflorescences are racemes of 2-14 flowers that are 25-40 mm long. Flowers are zygomorphic, their lowest sepal forming a sac that ends in a straight spur.
    [Show full text]
  • Testing Testing
    Testing…testing… Background information Summary Students perform an experiment Most weeds have a variety of natural to determine the feeding enemies. Not all of these enemies make preferences of yellow admiral good biocontrol agents. A good biocontrol caterpillars. agent should feed only on the target weed. It should not harm crops, natives, Learning Objectives or other desirable plants, and it must not Students will be able to: become a pest itself. With this in mind, • Explain why biocontrol agents when scientists look for biocontrol agents, are tested before release. they look for “picky eaters”. • Describe how biocontrol agents are tested before Ideally, a biocontrol agent will be release. monophagous—eating only the target weed. Sometimes, however, an organism Suggested prior lessons that is oligophagous—eating a small What is a weed? number of related plants—is also a good Cultivating weeds agent, particularly when the closely related plants are also weeds. Curriculum Connections Science Levels 5 & 6 In order to test the safety of a potential biocontrol agent, scientists offer a variety Vocabulary/concepts of plants to the agent in the laboratory Choice test, no choice test, and/or in the field. They choose plants repeated trials, control, economic that are closely related to the target threshold weed, as these are the most likely plants to be attacked. The non-target plants Time tested may be crops, native plants, 30-45 minutes pre-experiment ornamentals, or even other weeds. The discussion and set-up tests are designed to answer two main 30-45 minutes data collection questions: and discussion 1.
    [Show full text]
  • Yellow Archangel Lamium – a Devil to Control!
    ALIEN PLANT INVADERS: Yellow Archangel Lamium – A Devil To Control! A series of articles on how to identify and manage some common invasive species on Salt Spring Island, by Jean Wilkinson, Stewardship Committee, Salt Spring Island Conservancy (former articles available on SSIC Web-site) The spread of invasive species is a very serious threat to our native flora and ecosystems, but we can help reduce the impacts of invasive plants by not planting them and by preventing and controlling infestations in our yards and neighbourhoods. In our region one of the most common and challenging invasive plants is Yellow Archangel, aka Dead-nettle. A type of Lamium native to Europe, Asia, and North Africa, it is often used in hanging baskets or sold as a low maintenance, fast- growing perennial ground-cover, easily adaptable to sun or shade. This description should trigger alarm bells! Such plants can quickly take over garden beds and invade nearby natural areas, and they’re difficult to control and remove. Avoiding this problem by planting non-invasive alternatives (see below) is the best policy, but established patches of Lamium and other invasive species can be removed with a bit of effort. Yellow Archangel is particularly problematic as it often spreads into undisturbed wooded areas, forming thick mats and smothering the native plants that provide habitat for wildlife. Large areas can be severely impacted by the dumping of a single hanging basket. Other Lamium varieties (eg L. purpureum) also escape gardens, so if you’re set on growing any of these, please keep them in a contained area, away from the edges of woods or meadows, and be sure to deadhead the flowers.
    [Show full text]
  • Dietary Neurotransmitters: a Narrative Review on Current Knowledge
    nutrients Review Dietary Neurotransmitters: A Narrative Review on Current Knowledge Matteo Briguglio 1,* ID , Bernardo Dell’Osso 2,3, Giancarlo Panzica 4 ID , Antonio Malgaroli 5, Giuseppe Banfi 6, Carlotta Zanaboni Dina 1, Roberta Galentino 1 and Mauro Porta 1 1 Tourette’s Syndrome and Movement Disorders Centre, I.R.C.C.S. Galeazzi Hospital, 20161 Milan, Italy; [email protected] (C.Z.D.); [email protected] (R.G.); [email protected] (M.P.) 2 Department of Pathophysiology and Transplantation, I.R.C.C.S. Ca’ Granda Foundation, Ospedale Maggiore Policlinico, 20122 Milan, Italy; [email protected] 3 Department of Psychiatry and Behavioral Sciences, School of Medicine, Stanford University, Stanford, CA 94305, USA 4 Department of Neuroscience, Rita Levi Montalcini, University of Turin, 10126 Turin, Italy; [email protected] 5 Neurobiology of Learning Unit, Division of Neuroscience, Vita-Salute San Raffaele University, 20132 Milan, Italy; [email protected] 6 Scientific Direction, I.R.C.C.S. Galeazzi Hospital, 20161 Milan, Italy; banfi[email protected] * Correspondence: [email protected]; Tel.: +39-338-608-7042 Received: 13 April 2018; Accepted: 8 May 2018; Published: 13 May 2018 Abstract: Foods are natural sources of substances that may exert crucial effects on the nervous system in humans. Some of these substances are the neurotransmitters (NTs) acetylcholine (ACh), the modified amino acids glutamate and γ-aminobutyric acid (GABA), and the biogenic amines dopamine, serotonin (5-HT), and histamine. In neuropsychiatry, progressive integration of dietary approaches in clinical routine made it necessary to discern the more about some of these dietary NTs.
    [Show full text]
  • Deep Roots Radio 2020 Spring Herbs 1
    RED CLOVER HERBAL APOTHECARY FARM SPRING HERBS Stinging Nettles (Urtica dioica) leaf, root and seeds One of my very favorite herbs • Use as a tea or in plant extracts. Use as a food - saute in olive oil with garlic, add to pasta dishes, make Nettle leaf lasagna. Use the dried seeds at end of growing season • Stinging nettle is a powerful source of many nutrients, calcium, manganese, magnesium, vitamin K, carotenoids, and protein • Because of its high mineral content, Nettle strengthens bones, hair, nails, and teeth. • Nettles build red blood cells so boosts iron levels. Many women this instead of iron pills when pregnant. Restoring iron levels can also relieve fatigue. • Nettles natural histamine may decrease seasonal allergic responses, such as hay fever. Suggested use for allergies - make a strong nourishing infusions (1 ounce of nettle leaf by weight, infused in 32 ounces of just-boiled water for 4-8 hours) Drink this daily in the time leading up to allergy season. This often eliminates or strongly decreases allergy symptoms • There's the old tale of Elders running naked through the Nettle patches. Stinging nettle hairs contain several chemicals that have pain-relieving and anti-inflammatory properties. This means that stinging nettle could help reduce pain and inflammation in conditions such as arthritis. • Nettle stings contain histamine that causes the initial reaction when you are stung. Dock leaf sap contains natural antihistamine, which helps to ease the stinging sensation. • Stinging Nettle seed is currently being used in clinical practice as a trophorestorative for degenerative kidney disease. A trophorestorative nourishes and restores the function of a tired, compromised, diseased tissue, organ, or system.
    [Show full text]
  • As an Aqueous Plant-Based Extract Fertilizer in Green Bean (Phaseolus Vulgaris L.) Sustainable Agriculture
    sustainability Article Stinging Nettle (Urtica dioica L.) as an Aqueous Plant-Based Extract Fertilizer in Green Bean (Phaseolus vulgaris L.) Sustainable Agriculture Branka Mariˇci´c 1,*, Sanja Radman 2, Marija Romi´c 2, Josipa Perkovi´c 3 , Nikola Major 3 , Branimir Urli´c 4, Igor Palˇci´c 3,* , Dean Ban 3, Zoran Zori´c 5 and Smiljana Goreta Ban 3 1 Department of Ecology, Agronomy and Aquaculture, University of Zadar, 23000 Zadar, Croatia 2 Faculty of Agriculture, University of Zagreb, 10000 Zagreb, Croatia; [email protected] (S.R.); [email protected] (M.R.) 3 Institute of Agriculture and Tourism, Department of Agriculture and Nutrition, 52440 Poreˇc,Croatia; [email protected] (J.P.); [email protected] (N.M.); [email protected] (D.B.); [email protected] (S.G.B.) 4 Institute for Adriatic Crops and Karst Reclamation, Department of Plant Sciences, 21000 Split, Croatia; [email protected] 5 Faculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, Croatia; [email protected] * Correspondence: [email protected] (B.M.); [email protected] (I.P.); Tel.: +385-98-981-7375 (B.M.); +385-408-312 (I.P.) Abstract: Plant-based fertilizers, such as liquid plant extracts, contribute to the cultivation of veg- etables, particularly in organic production. The objective of this study was to determine if aqueous nettle extract could be successfully used as a fertilizer, applied on the soil and foliarly, in green bean Citation: Mariˇci´c,B.; Radman, S.; production under field conditions. The hypothesis was that it could successfully replace mineral Romi´c,M.; Perkovi´c,J.; Major, N.; fertilizers and be integrated into sustainable and organic agriculture.
    [Show full text]
  • Medicine Plants of Folk Medicine Used for Treatment of Gastro-Intestinal Problems in Fergana Valley
    국내․외 기술정보 Medicine plants of folk medicine used for treatment of gastro-intestinal problems in Fergana valley Valeriy V. Pak 식품기능연구본부 This article presents a review of indigenous medicinal plants used in folk medicine in Fergana valley (Uzbekistan) for treatment of gastro-intestinal problems. The 29 different plantsbelong to 18 different plant spices are presented. The methods of preparation of remedies and utilized parts of plants are described. Ⅰ. Introduction The purpose of this article is to review the remedies of the folk medicine for treatment of Plant products – as part of foods or botanical gastro-intestinal problems used in Fergana portions and powder – have been used with valley presenting the most densely populated varying success to cure and prevent diseases part of Uzbekistan. throughout history. Several diverse line of evidence indicates that medicinal plants represent the oldest and most widespread form of Ⅱ. Geographic characteristic medication. Until recently, plants were an of Fergana valley important source for the discovery of novel pharmacologically active compounds, with many Fergana valley occupiesa territory about 22.000 blockbuster drugs being derived directly or sq km and divided among Uzbekistan, Tajikistan indirectly from plants [1,2]. As it is estimated and Kyrgystan (Fig. 1). The Fergana Range by World Health Organization (WHO) that 25 % rises in the northeast and the Pamir in the of the active compounds in currently prescribed south. The Gissar and Alay ranges stand across synthetic drugs were first identified in plant the Fergana valley, which lies south of the sources [3]. Thus, to collect information about western Tian-Shan. The Xinjiang region of medicine plant used in folk medicine is valuable China borders the valley in the southeast.
    [Show full text]