Anti-PREB (Aa 37-248) Polyclonal Antibody (DPABH-12270) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-PREB (aa 37-248) polyclonal antibody (DPABH-12270) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription (By similarity). Guanine nucleotide exchange factor that activates SARA2. Required for the formation of COPII transport vesicles from the ER.

Immunogen Recombinant fragment corresponding to Human PREB aa 37-248. (BC002765)Sequence: AKTG IKNGVHFLQL ELINGRLSAS LLHSHDTETR ATMNLALAGD ILAAGQDAHC LLRFQAHQQ QGNKAEKAGS KEQGPRQRKG AAPAEKKCGA ETQHEGLELR VENLQAVQTD FSSDPLQKVV CFNHDNTLLA TGGTDGYVRV WKVPSLEKVL EFKAHE

Isotype IgG

Source/Host Rabbit

Species Reactivity Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications WB, IHC-P

Format Liquid

Size 100 μg

Buffer pH: 7.20; Constituents: 98% PBS, 1% BSA

Preservative 0.02% Sodium Azide

Storage Shipped at 4°C. Store at 4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.

GENE INFORMATION

Gene Name PREB prolactin regulatory element binding [ Homo sapiens ]

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Synonyms PREB; prolactin regulatory element binding; prolactin regulatory element-binding protein; SEC12; prolactin regulatory binding-element protein; mammalian guanine nucleotide exchange factor mSec12; MGC3467;

Entrez Gene ID 10113

Protein Refseq NP_037520

UniProt ID Q9HCU5

Chromosome Location 2p23

Pathway Activation of Chaperone Genes by XBP1(S); Activation of Chaperones by IRE1alpha; Asparagine N-linked glycosylation; COPII (Coat Protein 2) Mediated Vesicle Transport; Diabetes pathways; Disease; ER to Golgi Transport

Function DNA binding;

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]