St George & Sutherland Hospitals | 2010/2011

St George & Sutherland Hospitals | 2010/2011 Research Report INTRODUCTION

Medical research - whether it be the molecular exploration of the genome or the skillful evaluation of a standard clinical procedure - is what adds intellectual zest to clinical medicine. The St George and Sutherland Medical Research Foundation exists to support that research. Of course, it is important not only that medical research happens in our hospitals but that we know, and we let others know, what is being done, where it is being published and when it wins major research grants in the peer-review process. The 2010-11 Research Report provides an excellent audit of current activity.

Professor John Edmonds Chair, St George & Sutherland Medical Research Foundation

At St George and Sutherland hospitals, we are extremely fortunate to have a group of world-class researchers who have made significant contributions to the advancement of medical knowledge. We are proud that a major result of these research efforts has been significant improvements in the way we approach the diagnosis and treatment of a wide range of common and uncommon illnesses. The St George and Sutherland research foundation has been pivotal in contributing to our success in research, particularly through supporting promising new researchers and by providing seed funding to allow novel cutting edge research projects to develop. We recognise how important it is to share our research and medical achievements with our colleagues, community and supporters. Our research report for 2011-2012 therefore, reflects our achievements and ongoing endeavours in this challenging, yet most rewarding field.

A/Professor Amany Zekry Associate Professor of Medicine & Head of Gastroenterology and Hepatology St George Hospital

The Sutherland Hospital and Community Health Services have been involved in clinical research conducted by multiple medical specialties and disciplines. Research has been undertaken by medical, nursing and allied health groups. Some of these projects have been site speciﬁc but others have been collaborative with other centres including universities and hospitals.

The advantage that Sutherland has is its high clinical output to optimise numbers of participants in studies and its close, integrated relationship between hospital and community. The future in research through relationships with organisations such as the St George and Sutherland Medical Research Foundation is very encouraging and exciting.

A/Prof Peter Gonski Head, Sutherland Teaching Unit, St George Clinical School

1 Research in our teaching hospitals has long been a fundamental underpinning for the excellence in clinical care to which we all subscribe, and most would agree that this will not change in the future. St George has played a historically important role in pursuit of advances in basic and clinical sciences, while we have been less ready than many others to trumpet those achievements. This important report demonstrates the extraordinary breadth and impressive depth of research activities undertaken at St George.

This is a document to be proud of, to work over coming years to improve on, and to use widely and loudly to push our case for just recognition of our contributions. It incorporates the efforts of hospital and UNSW staff across a range of disciplines and Schools. Read it, and be impressed. We owe a debt of gratitude to the few who have done most to bring this report to fruition.

Professor Michael Grimm Clinical Associate Dean St George Clinical School, UNSW

Research and Innovation led by nurses at St George Hospital continues to grow and to make major contributions to the health and wellbeing of the people. My appointment to the Acute Care Nursing Research Unit at St George Hospital in January 2012 is a testament to the hospital’s commitment to further encourage and support nurses to continue to develop their research capacities and to produce high quality research.

Our challenge is to take the Acute Care Nursing Research Unit to the next level of excellence. So as we move forward together towards a shared vision of excellence we will require to make a far more concerted effort so that research and clinical practice will be mutually reinforcing. I look forward to working with you to achieve this vision.

Professor Ritin Fernandez Professor of Nursing

2 CONTENTS

CLINICAL GROUPS – ST GEORGE HOSPITAL & SUTHERLAND HOSPITAL

1. MEDICINE & CRITICAL CARE

Cardiology ...... 5 Dermatology ...... 8 Emergency Medicine ...... 23 Endocrinology ...... 28 Gastroenterology & Hepatology ...... 33 Immunology & Infectious Diseases ...... 48 Intensive Care Medicine ...... 57 Nuclear Medicine ...... 71 Neurology ...... 75 Renal Medicine ...... 77 Respiratorys ...... 89 Rheumatology ...... 95

2. SURGERY, PERIOPERATIVE CARE & CANCER SERVICES

Surgery: Cardiothoracic ...... 99 Gastrointestinal: - Liver (see UNSW Surgery) ...... 101 - Colo-rectal ...... 118 Neurosurgery ...... 121 Orthopaedics ...... 123 Trauma...... 138 Vascular ...... 146

Cancer Care: Haematology ...... 148 Medical Oncology ...... 169 Radiation Oncology ...... 180 Palliative Care ...... 203

3 3. WOMEN’S AND CHILDREN’S HEALTH

Women’s Health ...... 213 Urogynaecology ...... 222 Paediatrics ...... 228

4. AGED AND EXTENDED CARE AND REHABILITATION

Aged Care ...... 236 Rehabilitation ...... 239 Southcare, Division of Aged and Extended Care ...... 241

5. ALLIED HEALTH SERVICES

Physiotherapy ...... 243 Occupational Therapy ...... 248 Speech Therapy ...... 251 Nutrition and Dietetics ...... 253 Mental Health ...... 257

4 MEDICINE & CRITICAL CARE

DEPARTMENT OF CARDIOLOGY

DEPARTMENTAL STAFF*

Head of Department Mark Sader (Director)

Senior medical staff Staff specialists David Ramsay David Rees Andrew Hopkins Maurits Binnekamp Ananth Prasan George Youssef James Weaver Queenie Lo Ee Mai Chia

Research Staff Senior research staff Dr. Ananth Prasan Dr. James Weaver

Nursing research staff Kate Dobinson Helen Goldsmith Glenn Paull Janet Newton

5 RESEARCH GRANTS#

Category II - Other competitive grants: St George and Sutherland Medical Research Council - Establishment grant (new appointee). Dr James Weaver Title: Endothelial dysfunction and platelet activation in the setting of coronary disease.

RESEARCH PROJECTS IN PROGRESS

CARDIOLOGY CLINICAL TRIALS (industry sponsored) - 2010 to 2011

Title Investigator

Cardiovascular outcomes study to evaluate the potential of study drug to reduce cardiovascular risk Dr. Ananth Prasan in patients with recent ACS event and T2D.

Trial Evaluating CV Outcomes with study drug in patients with Type 2 Diabetes. Dr. Maurits Binnekamp

Evaluation of the safety and efﬁcacy of short-term study drug treatment in subjects with ACS. Dr. George Youssef

Study drug in 1-3yr post MI pts Dr Mark Sader

Study to evaluate Cardiovascular Outcomes Following Treatment with study drug in Addition to Dr Ananth Prasan Standard of Care in Subjects with Type 2 DM and ACS.

Future revascularization evaluation in patients with diabetes mellitus: optimal management of Dr Ananth Prasan multivessel disease.

The Advisa MRI System study is a prospective, randomised controlled, non-blinded, multi centre Dr. Andrew Hopkins worldwide investigational study.

A Multicentre, Randomised, Double blind, Placebo-Controlled Study to Evaluate the Safety and Efficiency of study drug in Addition to Standard of Care in subjects with atherosclerotic Disease. Dr George Youssef Thrombin Receptor Antagonist in Secondary Prevention of Artherothrombotic Ischemic Events. A randomised, double-blind, placebo-controlled study to evaluate the safety of 12 weeks of dosing with study drug and its effects on inflammatory markers, infarct size, and cardiac function in subjects Dr. Ananth Prasan with myocardial infarction without STEMI A Multicentre, Randomised, Double blind, Placebo-Controlled Study to Evaluate the Safety and Efficiency of study drug in Addition to Standard of Care in subjects with Acute Coronary Syndrome. Dr Ananth Prasan Thrombin Receptor Antagonist in Acute Coronary Syndrome.

Percieved risk of ischemia and bleeding in acute coronary syndrome patients. Dr. Ananth Prasan

A Phase 3, Randomised, Double-Blind, Evaluation of the Safety and Efﬁciency of study drug In Dr. Ananth Prasan Subjects with a recent ACS

Inhibition of protein kinase c for the reduction of infarct size in AMI. Dr Ananth Prasan

6 ORIGINAL PEER - REVIEWED PUBLICATIONS

Krishnaraj M, Arendts G, Paull G, Rees D. Current management of atrial ﬁbrillation in the acute setting – ﬁndings from an Australasian survey. Heart, Lung and Circulation 2010, 19 (7) 423-427.

Weaver J, McCrohon J A, Rees D, Prasan AM. Multivessel coronary-ventricular ﬁstulae and ischaemia on cardiac MRI. International Journal of Cardiology. 2010;139:e36-e38.

Kidson-Gerber G, Weaver JC, Gemmell R, Prasan A, Chong BH. Serum Thromboxane B2 and other platelet function tests in patients with stable cardiovascular disease administering aspirin and/or clopidogrel. Heart Lung and Circulation. 2010; 19:234-242.

Weaver J, Ramsay DR, Rees D, Binnekamp MF, Prasan AM, McCrohon JA. Dynamic changes in ST segment resolution after myocardial infarction and the association with microvascular injury on cardiac magnetic resonance imaging. Heart Lung and Circ. 2011; 20:111-118. Weaver J, Rees D, Prasan AM, Ramsay DR, Binnekamp MF and JA McCrohon. Grade 3 ischaemia on the admission electrocardiogram is associated with severe microvascular injury on cardiac MRI after ST elevation myocardial infarction. Journal of Electrocardiology. 2011;44:49-57.

Davidson PM, Daly J, Leung D, Ang E, Paull G, DiGiacomo M, Hancock K, Yingjuan Cao, HuiYun Du, Thompson DR. Health-seeking beliefs of cardiovascular patients: A qualitative study. International Journal of Nursing Studies, 2011, 48(11):1367-75

OTHER PUBLISHED MATERIAL (books, book chapters, reviews)

None reported.

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

Paull G. Implantable Cardioverter Deﬁbrillators / End of Life Care. Cardiovascular Health and Rehabilitation Association of NSW and ACT Extreme Cardiovascular Issue Conference . 21st May 2010 Sydney, Australia

Paull G, Gallagher R, Ang E, Ferry C, Agostino J, Arndt M, Baxter A, Connolly B, Davis S, Hraiki N, Newton J, Ratnarajah M, Vuong N. Chronic Disease Self Management: multilingual audiovisual resources for Ischaemic Heart Disease and Chronic Heart Failure. 59th Annual Scientiﬁc Meeting of Cardiac Society of Australia and New Zealand 2011 - Perth, Australia 2011

7 DEPARTMENT OF DERMATOLOGY

DEPARTMENTAL STAFF

Head of Department *Dedee F Murrell MA(Cambridge) BMBCh (Oxford) FAAD (USA) MD (UNSW) FACD (Conjoint Professor, Faculty of Medicine UNSW)

Senior Medical Staff Visiting Medical Ofﬁcers *Anthony J Cronin MBBS (Syd) PhD (Cambridge) FACD *Mei-Heng Tan MBBS (Syd) FAAD (USA) Lizbeth Ruth A. Intong MD FPDS (Honorary VMO) Clarissa Mendoza MD FPDS (Honorary VMO) (2011)

*Dept Administrative assistant: Glendi McNab

Junior Medical Staff *RMOs: Jessica Chen, Gloria Kuo 2010 *Dermatology Registrar: Georgia Harris 2011

Elective Students 2010 Christian Castro, Univ Maastricht, NL Jennifer Kuijlaars, Univ Maastricht, NL Lilian Pilcher, Basel, Switzerland 2011 Bart Wagemans, Univ Maastricht, NL Karoline Von-Loeper, Tuebingen Univ, Germany Ingrid Meuwissen, Univ Maastricht, NL Kendall Sharpe, Univ Western Australia Nader Beshay, UNSW

Overseas visiting dermatology mentees 2010 Johnny Gurgen, Univ of Florida

Overseas Visiting Academic Staff: Dr M Tariq Khan, Consultant Podiatrist & Specialist in Homoeopathic Podiatry and Dermatology. (6 Months) Great Ormond Street Hospital, London England 2011 Dr (Peter) Thach Ngoc Hoang, Pathologist, National Hospital of Paediatrics, Hanoi Vietnam 2011

8 Research Staff Senior research staff Lizbeth Ruth A Intong MD FPDS Post dermatology research fellow Clarisse Ayeese Mendoza MD FPDS Post dermatology research Fellow 2011

Junior Research Staff Benjamin S Daniel B.Com, MBBS- Predermatology research fellow

Research Students Wenfei Yan MD China - ﬁnal year PhD student; Supriya Venugopal MBBS – p/t PhD student; Heather Cohn, Postdoc 2010

Honours student: Chris Lim 2011

ILP students 2010 Andrew Dermawan, Shelley Hwang, Min-Hee Kim, Angelika Trodjikaya

ILP students 2011 Jeremy Tan, Lawrence Oh

Nursing Research Staff Lesley M Rhodes RN *Funded by St George Hospital; rest from external sources.

RESEARCH GRANTS

National, peer reviewed: NHMRC Project Grant: Investigation of ﬂightless-1 in epidermolysis bullosa. Allison Cowin, Ruth Arkell, Dedee Murrell. $517,500

NRISS Grant for allogeneic cultured ﬁbroblast trial in recessive dystrophic EB. Marian Sturm, Dedee Murrell Cell and Tissue Therapies, Royal Perth Hospital, 2008-2010 $99,000

Lord Mayor’s Charitable Foundation, Major Grant, $160,000 for funding of a clinical nurse consultant for adult patients with Epidermolysis Bullosa (Foote family award) 2010-12

Grant for Biologics Clinic, Abbott Pharmaceuticals $15,000 2011

Grant for Biologics Clinic Nurse, Schering Plough Pharmaceuticals, $11,000 2011

Caroline Quinn Memorial Fund grant $40,000 for research in EB 2011

9 Other Funding DebRA Australia $10,000 towards National EB Registry 2010, 2011

America-Australia Association for Heather Cohn, Jefferson Univ, PA, USA Sir Keith Murdoch Fellow– genetic risk factors for SCC in EB- 2010 ($25,000)

University Post-graduate Awards for PhD students Wenfei Yan and Supriya Venugopal

RESEARCH PROJECTS IN PROGRESS

Title Investigators

Dedee Murrell PI) ; Supriya Venugopal; RCT of allogeneic ﬁbroblast cell therapy for recessive dystrophic EB Hellen Yan; Lesley Rhodes; John Frew; Heather Cohn

Dedee Murrell, Minhee Kim, Epidemiology and outcomes of squamous cell carcinoma in EB Supriya Venugopal

Genetic modiﬁers of risk for squamous cell carcinoma in EB Murrell DF, Cohn H

Dedee Murrell, Ann-Marie Hanna, Development of a quality of life instrument for autoimmune blistering diseases, Deshan Sebaratnam, Shienning Chee, the ABQOL Angelika Trodjikawa, Supriya Venugopal

International validation of the QOLEB, the qualify of life measure we developed Dedee Murrell, John Frew and published for Australian patients with EB.

Murrell, Daniel, Venugopal, Linda Martin, RCT of Recell vs punch grafting for chronic stable vitiligo. John Le Guay, Richard Wittal, Lesley Rhodes

Australasian EB Registry Murrell, Rhodes

Murrell, Intong LRA, Choi DS, Rhodes LM, Outcomes of pregnancies in EB. Chapman M

Trial of gentian violet for Junctional EB Murrell, Venugopal

Response of multiple recalcitrant verrucae to gardasil vaccine. Murrell, Venugopal, Daniel

Role of ﬂightless-1 in EB and EBA Kopecki, Murrell, Cowin

AIBD Registry Dermawan, Intong, Murrell

Epidemiology of SCC in EB in Australia Min-Hee Kim, Intong, Rhodes, Murrell

Epidemiology of Anaemia in EB Hwang, Daniel, Murrell

10 ORIGINAL PEER-REVIEWED PUBLICATIONS (authors in Bold are at St George Hospital)

Lara-Corrales I, Mellerio J, Lucky AW, Azizkhan RG, Murrell DF, Agero ALC, Kantor P, Pope E. Dilated Cardiomyopathy in Epidermolysis Bullosa, a retrospective, multicenter study. Pediatr Dermatol 27:238-243, 2010.

Venugopal S, Murrell DF: Complete remission of cutaneous warts using the Gardasil vaccine in a developmentally delayed, thirty one year old Caucasian man. The Cutting Edge, Arch Dermatol 146: 475-477, 2010. van Geel M, Gattas M, Kesler Y, Tong P, Yan WF, Tran K, Steijlen PM, Murrell DF, van Steensel MAM: Novel WNT10A nonsense mutations in odonto-onycho-dermal dysplasia. Br J Dermatol DOI: 10.1111/j.1365-2133.2010.09703.x:162:1403-6, 2010.

Wriston CC, Rubin AI, Martin LK, Kossard S, Murrell DF: Plaque-like Cutaneous Mucinosis: Case Report and Literature Review. Am J Dermpath (in press August 2010)

YC Kho, AL Agero, LM Rhodes, S Robertson, J Su, G Varigos, I Robertson, P Hogan, DOrchard, DF Murrell. Epidemiology of EB in the Antipodes: the Australasian EB Registry with a focus on Herlitz Junctional EB. Arch Dermatol 146(6): 635-60, 2010 (featured on the front cover of the journal). Winner of UNSW Dean’s List Award to student Yong Kho 2010.

Venugopal SS, Intong LRA, Cohn HI, Mather-Hillon J, Murrell DF: Responsiveness of non-Herlitz junctional epidermolysis bullosa to topical gentian violet. Int J Dermatol 2010 Nov;49(11):1282-5. doi: 10.1111/j.1365-4632.2010.04557.x.

Venugopal SS, Murrell DF: Seasonal onychomadesis in an elderly gentleman. Dermatology Reports 2009, Issue 1, Vol 1: e3.

Frew JW & Murrell DF: Quality of Life Measurements in Epidermolysis Bullosa: Tools for Clinical Research & Patient Care. Dermatol Clin N Am, 2010, 28(1):185-190.

Cohn HI & Murrell DF: Laryngo-onycho-cutaneous syndrome. Dermatol Clin N Am, 2010, Part I: Epidermolysis Bullosa, 2010, 28 (1): 89-93.

Tosti A, Duque-Estrada B, Murrell DF: Alopecia in Epidermolysis Bullosa. Dermatol Clin N Am, 2010, 28 (1): 165-170.

Tosti A, Cadore de Farias D, Murrell DF: Nail involvement in Epidermolysis Bullosa. Dermatol Clin N Am, 2010, 28 (1): 153-158.

Figuiera EC, Murrell DF, Coroneo MT: Epidermolysis Bullosa and the Eye.Dermatol Clin N Am, 2010, 28 (1): 143-152. Intong LRA, & Murrell DF: How to Take Skin Biopsies for Epidermolysis Bullosa. Dermatol Clin N Am, 2010, 28 (2): 197-200.

11 Venugopal SS & Murrell DF: Management of Squamous Cell Carcinoma in Epidermolysis Bullosa. Dermatol Clin N Am, 2010, 28 (2): 283-288.

Yan WF, Murrell DF: Cell therapy for dystrophic epidermolysis bullosa. Dermatol Clin N Am, 2010, 28 (2): 367-370.

Murrell DF: Epidermolysis Bullosa in Australia and New Zealand. Dermatol Clin N Am, 2010, 28 2): 433-438.

Sebaratnam DF, Martin LK, Rubin AI, Tran K, Pas HH, Marr PJ, Edmonds J, Murrell DF: Reversible relapse of pemphigus foliaceus triggered by topical imiquimod suggests Toll-like receptor 7 inhibitors may be useful treatments for pemphigus. Clin Exp Dermatol. Jan;36(1):91-3. doi: 10.1111/j.1365- 2230.2010.03918.x. Epub 2010 Sep 1. Jan 2011 (image from article featured on front cover of journal).

Martin LK, Werth VP, Villanueva E, Murrell DF: A systematic review of randomized controlled trials for Pemphigus Vulgaris and Pemphigus Foliaceus. J Am Acad Dermatol 2011, May;64(5):903-8, 10.1016.

Choi SD, Intong LRA, Kho YC, Rhodes LM, Chapman MG, Murrell DF: Outcomes of 11 pregnancies in 3 patients with recessive forms of epidermolysis bullosa. Br J Dermatol 2011, Sep; 165(3):700-1, 2011. doi: 10.1111/j.1365-2133.2011.10441.x.

Sebaratnam DF, Venugopal SS, Murrell DF: A comparison in real clinical practice of methyl aminolevulinate photodynamic therapy and surgery for small superﬁcial basal cell carcinoma: 3-year recurrence rates and cosmetic outcomes. JEADV 2011 Jan;25(1):117-8. doi: 10.1111/j.1468- 3083.2010.03697.x.).

Purdie K, Pourreyron C, Fassihi H, Cepeda R, Volz A, Weissenborn S, Pﬁster H, Proby C, Bruckner- Tuderman L, Murrell DF, Salas-Alanis JC, McGrath JA, Leigh IM, Harwood C, South AP: Squamous cell carcinoma in patients with recessive dystrophic epidermolysis bullosa are not associated with high risk mucosal human papillomaviruses and do not exhibit increased infection of beta papillomaviruses. J Invest Dermatol, :130(12): 2853-5. DOI 10.1038/jid2010.243).

Fang Z, Kozlov S, McKay MJ, Woods R, Birrel G, Sprung CN, Murrell DF, Wangoo K, Teng L, Kearsley JH, Lavin MF, Graham PH, Clarke RA: Low levels of ATM in breast cancer patients with clinical radiosensitivity. Genome Integrity 2010, 1:9 doi:10.1186/2041-9414-1-9.

Frew JW, Lim S-W, Klausseger A, Chow CW, Tran K, Su J, Orchard D, Varigos G, Sawamura D, Nishie W, Shimizu H, Murrell DF: Autosomal Dominant Bullous Dermolysis of the Newborn Associated with a Heterozygous Mis-sense Mutation p.G1673R in Type VII Collagen. Australas J Dermatol 2010 Published Online 23/8/10 Nov; 52(4):e1-4.DOI: 10.1111/j.1440-0960.2010.00684.

Daniel BS and Murrell DF. The actual management of pemphigus. G Ital Dermatol Venereol. 2010 Oct; 145(5):689-702.

12 Kirtschig G, Middleton P, Bennett C, Murrell DF Wojnarowska F, Khumalo N, Interventions for bullous pemphigoid. The Cochrane Database of Systematic Reviews Issue 10, 2010 Oct 6; 10:CD002292.

Daniel BS and Murrell DF: Chronic urticaria resolving after resection of mucinous breast cancer. J Clin Exp Dermatol 1:103, 2010. DOI 10.4172/2125.9554.1000103.

Yiu EM, Klausegger AK, Waddell LB, Grasern N, Lloyd L, Tran K, North KN, Bauer JW, McKelvie P, Chow CW, Ryan MM, Murrell DF. Epidermolysis bullosa with late-onset muscular dystrophy and plectin deﬁciency. Muscle Nerve Jul; 44(1):135-41, 2011. doi: 10.1002/mus.22076.

Martin LK, Murrell DF: Pemphigus: Directions for the future. J Am Acad Dermatol. May; 64(5): S909-10, 2011.

Murrell DF, Ryan TJ, Bergfeld WF. Advancement of Women in Dermatology. Int J Dermatol. 2011 May;50(5):593-600. doi: 10.1111/j.1365-4632.2011.05075.x

Venugopal S & Murrell DF: Diagnosis and Clinical features of pemphigus vulgaris. Dermatol Clin Jul;29(3):373-80, vii, 2011.

Sebaratnam DF & Murrell DF: Objective scoring systems for disease activity in autoimmune blistering diseases. Dermatol Clin Jul; 29(3):515-20, xi, 2011.

Chee SN & Murrell DF: Pemphigus and Quality of Life. Dermatol Clin Jul; 29(3):521-5, xi-ii.: 2011.

Intong LRA & Murrell DF: Pemphigoid gestationes: Pathogenesis and Clinical Features. Dermatol Clin Jul; 29(3):447-52, ix. 2011

Tosti A, Andre M Murrell DF: Nail involvement in autoimmune blistering diseases. Dermatol Clin Jul;29(3):511-3, xi. 2011.

Miteva M, Murrell DF, Tosti A: Hair loss in autoimmune cutaneous bullous disorders. Dermatol Clin Jul; 29(3):503-9, xi, 2011.

Murrell DF, Trisnowati N, Miyakis S and Paller AS: The yin and the yang of keratin amino acid substitutions and epidermolysis bullosa simples. J Invest Dermatol Sep 131 (() 1878-90, 2011 (invited commentary containing novel ﬁndings). doi: 10.1038/jid.2011.206. (1/40; IF 6)

Frew JW, Murrell DF. Corticosteroid Use in Autoimmune Blistering Diseases. Dermatol Clin. 2011 Oct; 29(4):535-44

Daniel BS, Murrell DF, Joly P. Rituximab and its use in autoimmune bullous disorders.Dermatol Clin. 2011 Oct; 29(4):571-5

Daniel BS, Borradori L, Hall RP, Murrell DF: Evidence-based management of bullous pemphigoid. Dermatol Clin 29 (4): 2011. doi:10.1016/j.det.2011.06.003.

13 Chee SN, Murrell DF: The use of intravenous immunoglobulin in autoimmune blistering diseases. Dermatol Clin 29 (4): 2011 doi:10.1016/j.det.2011.06.010.

Frew JW, Murrell DF: Paraneoplastic pemphigus (Paraneoplastic autoimmune multiorgan syndrome) Pathogenesis and clinical features. Dermatol Clin Jul; 29(3):419-25, viii. 2011

Gupta VK, Kelbel TE, Nguyen D, Melonakos KC, Murrell DF, Xie Y, Mullard A, Reed PL, Seiffert-Sinha K, Sinha AA. A globally available internet-based patient survey of pemphigus vulgaris: epidemiology and disease characteristics. Dermatol Clin. Jul; 29(3):393-404, vii-iii, 2011.

Lehman JS, Murrell DF, Camilleri MJ, Kalaaji AN. Infection and Infection Prevention in Patients Treated with Immunosuppressive Medications for Autoimmune Bullous Disorders. Dermatol Clin. 2011 Oct; 29(4):591-8.

Frew JW, Martin LK, Murrell DF. Evidence-based treatments in pemphigus vulgaris and pemphigus foliaceus. Dermatol Clin. 2011 Oct; 29(4):599-606.

Daniel BS, Dermawan A, Murrell DF. The autoimmune blistering diseases in Australia: status and services. Dermatol Clin. 2011 Oct; 29(4):687-90.

Murrell DF, Werth VP, Segall J, Zrnchik W, Stuart M, Sirois D. The international Pemphigus and Pemphigoid Foundation. Dermatol Clin. 2011 Oct; 29(4):655-7.

Sebaratnam DF, Murrell DF. Bullous systemic lupus erythematosus. Dermatol Clin. 2011 Oct; 29(4):649-53.

Intong LR, Murrell DF. Management of epidermolysis bullosa acquisita. Dermatol Clin. 2011 Oct; 29(4):643-7.

Intong LR, Murrell DF. Pemphigoid gestationis: current management. Dermatol Clin. 2011 Oct; 29(4):621-8.

Kopecki Z, Arkell RM, Strudwick XL, Hirose M, Ludwig RJ, Kern JS, Bruckner-Tuderman L, Zillikens D, Murrell DF, Cowin AJ. Overexpression of the Flii gene increases dermal-epidermal blistering in an autoimmune ColVII mouse model of Epidermolysis Bullosa Acquisita. J Pathol. In press June 2011.

Murrell DF, Daniel BS, Joly P, Borradori L, Amagai M, Hashimoto T, Caux F, Marinovic B, Sinha A, Hertl M, Bernard P, Sirois D, Cianchini G, Fairley JA, Jonkman MF, Pandya AG, Rubenstein D, Zillikens D, Payne AS, Woodley D, Zambruno G, Aoki V, Pincelli C, Diaz L, Hall RP, Meurer M, Mascaro JM Jr, Schmidt E, Shimizu H, Zone J, Swerlick R, Culton D, Lipozencic J, Bince B, Mimouni D, Grando S, Bystryn JC, Werth VP. Deﬁnitions and Outcome Measures for Bullous Pemphigoid: Recommendations by an International Panel of Experts. J Am Acad Dermatol. Accepted July 2011 Advance online Nov 2011. DOI: 10.1016/j.jaad.2011.06.032

14 OTHER PUBLISHED MATERIAL (Books, book chapters, reviews) Not to include conf abstracts

Sebaratnam D, Murrell DF Werth VP: Pemphigus. Evidence-based Dermatology. Textbook – Howard Maibach, Ed. 2010.

Daniel BS, Murrell DF. Epidermolysis Bullosa. In: Clinical Genomics: Practical Applications in Adult Patient Care. McGraw Hill and American College of Physicians, 2010.

Kim M-H, Murrell DF: Cutaneous sarcoidosis. Medical Observer, Jan 29th, 2010. p. 25.

Daniel B, Murrell DF: Palmoplantar psoriasis – management and biologicals. Medical Observer, March 3rd 2010, p 32.

Muller N, Murrell DF: Steroid-induced acne. Medical Observer, April 2nd 2010

Meijers W, Murrell DF: Vitiligo. Medical Observer. April 30th 2010.

Hanna AM, Murrell DF: Cutaneous T cell Lymphoma masquerading as tinea corporis. Medical Observer. May 28th, 2010, p.38.

Castro C, Intong LRA, Murrell DF: More than just a birthmark, Medical Observer. June 25th, 2010, p 35.

Kuijlaars J, Intong LRA, Murrell DF: Small boy’s big skin problem (Netherton Syndrome) Medical Observer. August 20th, 2010, p. 30.

Li MM, Intong LRA, Murrell DF. Axillary papules (Fox Fordyce disease). Medical Observer. September 17, p. 35, 2010..

Daniel BS, Murrell DF. Lichen amyloidosis. Medical Observer, Oct 15, p. 29, 2010.

Gurgen J, Murrell DF. Nodules of unusual origin (Leishmaniasis). Medical Observer, Nov 12, p.12, 2010.

Murrell DF: Dermatologic Clinics of North America. Guest Editor Autoimmune Blistering Diseases: Part 1: Diagnosis and Pathogenesis Part II: Management; Elsevier, July 2011.

Murrell DF: Dermatologic Clinics of North America. Guest Editor Autoimmune Blistering Diseases: Part II: Management; Elsevier, October 2011.

Up to date: invited editor for 3 chapters on Epidermolysis Bullosa, 2011

Murrell DF. Autoimmune Blistering Diseases Part 1- Pathogenesis and Clinical Features. Dermatol Clin 29 (3): 2011.

Murrell DF: Autoimmune Blistering Diseases Part II-Diagnosis and Management. Dermatol Clin. 2011 Oct;29(4):xv-xvi. Epub 2011 Aug 17

15 Intong LRA & Murrell DF: Genetics and molecular biology of the sexes. In: Parish LC, Brenner S, Ramos-e-Silva M, Parish JL, eds. Manual of Gender Dermatology. Sudbury, Mass: Jones & Bartlett Learning; 2011: 15-23.

Intong LRA, Murrell DF: Erythema Multiforme, Stevens-Johnson Syndrome, and Toxic Epidermal Necrolysis. In Harper’s Textbook of Pediatric Dermatology I & II, 3rd Edition. Publisher: Wiley- Blackwells. Editors: Alan D. Irvine, Peter H. Hoeger, Albert C. Yan. Published Online: 24 MAY 2011. DOI: 10.1002/9781444345384.ch78

Intong LRA, Murrell DF: Inherited epidermolysis bullosa: New Diagnostic Criteria and Classiﬁcation. Clinics in Derm 2011

Sebaratnam DF, McMillan JR, Werth V, Murrell DF: Quality of life in patients with bullous dermatoses. Clinics in Derm 2011.

Daniel BS, Hertl M, Werth VP, Eming R, Murrell DF: Severity Score Indexes for blistering diseases. Clinics in Derm 2011.

Hwang S, Daniel B, Murrell DF: Drug related Skin Reactions. Medical Observer, Feb 4, p. 25. 2011.

Tjokrowidjaja A, Daniel BS, Murrell DF: Hailey Hailey Disease. Medical Observer 2011.

Dermawan A, Daniel BS, Murrell DF: Pityriasis Rubra Pilaris. Medical Observer, 2011.

Mendoza C, Murrell DF. Treating Psoriasis. Australian Doctor, 5 August 2011, pp. 37-38.

Daniel BS, Murrell DF. Atopic Dermatitis – new column on adult dermatology. Australian Doctor 1 April pp 35-36.

Beshey N, Murrell DF: Itchy scratchy nipple. Australian Doctor 27 May 2011, p. 43.

Wagemans B, Daniel BS, Murrell DF: Australian Doctor Treatment resistant psoriasis. 24 June 2011 p. 43.

Lim C, Mendoza C, Daniel B, Murrell DF: Australian Doctor Acne vulgaris. 29 July 2011, p. 41.

Lim C, Daniel BS, Murrell DF: Vitiligo. Australian Doctor 9 Sept 2011, p. 39

Guest Editor, Dermatology Clinics of North America –

Two issues on Epidermolysis Bullosa – published March and September 2010. Book review published in J. Am Acad Dermatol March 2011; mentioned in What’s New in Dermatology Treatment, AAD 2011.

Two issues on Autoimmune Bullous Diseases; July & Oct 2011.

Editorial Board, Acta Dermatologica Croatica, 2009-

16 Editorial Board, International Journal of Dermatology – for Genodermatoses 2010-

ICD10 Classiﬁcation – revised for Epidermolysis Bullosa by invitation, 2011

Editor, Uptodate, Epidermolysis Bullosa.

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

Prof Dedee F Murrell:

INVITED LECTURES

Australasian Wound and Tissue Healing Society, Perth, March 2010 Cell therapy trial for recessive dystrophic EB

Dept of Dermatology, Necker Hospital for Children, Paris, France. 9th April 2010 What’s new in epidermolysis bullosa?

New Zealand Dermatologic Society, Christchurch, New Zealand, April 2010 Cell therapy trial for RDEB Commentary on Clinical Cases, Christchurch Hospital

Inaugural Meeting of the UNSW Dermatology Society, Oct 13th, 2010, Sydney Dermatology as a Career

CONFERENCE CONTRIBUTIONS

American Academy of Dermatology, Miami, March 4-9th Chair: Autoimmune bullous diseases Symposium Speaker: Quality of Life in AIBD Speaker: Management of EB – Genodermatoses forum Senior author – 2 presentations at Residents Fellows Symposium Senior author – 2 presentations at Medical Dermatology Society Co-Chair, Int’l Pemphigoid Consensus Group

Australasian Wound and Trauma Research Association, Annual Meeting, Perth, Mar 22-24th, Perth Convention Centre RCT of allogeneic cell therapy for wound healing in dystrophic epidermolysis bullosa (paper); Flightless expression in EB (coauthor, poster) New Zealand Dermatological Society, Christchurch, NZ, May 1-4th,

17 Chair, Genodermatoses session Papers: cell therapy for EB; Plec1 mutations in EBS with late onset muscular dystrophy Senior author of paper- genotype to phenotype in DEB-TDON Response of 4/4 cases of multiple verrucae to Gardasil vaccination

Australasian College of Dermatologists Annual Meeting, Darwin, May 15-19th Senior author of 13 abstracts, including two oral papers Registrar session – RCT of cell therapy for RDEB Free paper session – Australasian EB Registry Satellite meeting – What’s new in atopic dermatitis and medical spa therapy

Australasian Society for Dermatological Research, Cairns, June 2010 Senior author of 3 oral papers

European Society for Dermatological Research, Helsinki, Finland, Sept 2010 Senior author of plenary presentation on cell therapy trial in RDEB

The Malta Meeting, Oct 2-30-Nov 2nd, 2010, Malta (unable to attend due to health issues) Invited Co-Chair and speaker, genodermatoses session What’s new in epidermolysis bullosa? National Institutes of Health, Bethesda, Pemphigus Meeting, Nov 5-7 Invited speaker – quality of life in pemphigus Co-Chair, International Consensus meeting on Bullous Pemphigoid

CILAD, Latin American Dermatology Annual Meeting, Cancun, Mexico, Nov 10-14 Co-Chair and Invited speaker, Workshop on Epidermolysis Bullosa Chair, International Society for Dermatology Session Co-Chair, Women’s Dermatologic Society Rose Parade of Cases

OTHER INTERNATIONAL PRESENTATIONS BY RESEARCH FELLOWS AND STUDENTS:

Hanna A, Sebaratnam D, Chee SN, Venugopal S, Welsh B & Murrell DF. The development of a disease-speciﬁc quality of life instrument for autoimmune bullous diseases – the ABQOL [poster]. Medical Dermatology Society Meeting. Miami, Florida, USA. March 4, 2010.

Venugopal SS, Yan WF, Frew JW, Cohn HI, Tran K, Sturm M, Fogarty J, Marinkovich P, Igawa S, Ishida-Yamamoto A, Murrell DF. First double-blind RCT of intradermal allogeneic ﬁbroblast therapy for generalized severe recessive dystrophic epidermolysis bullosa randomized against placebo injections resulted in similar wound healing that is independent of collagen VII expression. J Invest Dermatol 130:S67, 2010. (Plenary).

Daniel BS, Venugopal SS, Martin LK, Wittal R, Rhodes LM, Le Guay J Murrell DF. A Randomised Controlled Trial of Minigrafting Vs ReCell in Stable Vitiligo. First Vitiligo World Congress. Milan, Italy, October 2010. Oral plenary paper.

18 Sebaratnam DS, Venugopal SS, Frew JW, McMillan JR, Murrell DF: A systematic review of diffuse melanosis cutis as a rare presention of metastatic melanoma. Poster presentation, World Congress of Melanoma, Sydney, Nov 2010. Pigment Cell and Melanoma 23(6); 974. A281.

National Sebaratnam D, Venugopal S, Murrell DF. A comparison of photodynamic therapy and surgery in superﬁcial basal cell carcinoma: 3 year recurrence rates and cosmetic outcome [oral presentation]. Australasian Society for Dermatology Research 7th Annual Scientiﬁc Meeting. Cairns, Queensland, Australia. June 19, 2010.

Sebaratnam D, Venugopal S, Murrell DF A clinical study comparing photodynamic therapy and surgery in superﬁcial basal cell carcinoma: 3-year follow-up investigating recurrence and cosmetic outcome [poster]. Australasian College of Dermatologists 43rd Annual Scientiﬁc Meeting. Darwin, Northern Territory, Australia. May 16, 2010. Prof Dedee F Murrell

Kho YC, Rhodes LM, Robertson S, Su J, Varigos G, Hogan P, Orchard D, Murrell DF. (2010).The Australasian Epidermolysis Bullosa Registry – First Orphan Disease Registry in Australia (Oral Plenary Presentation). Australasian College of Dermatologist’s 43rd Annual Scientiﬁc Meeting, Darwin, NT, Australia.

Venugopal SS, Yan H, Tran K, Sturm M, Fogarty J, Nelson J, Frew JW, Melbourne W, Rhodes LM, Wood F, Marinkovich MP, Igawa S, Ishida-Yamamoto A, Murrell DF. Investigation of cell therapy for generalized severe recessive dystrophic epidermolysis bullosa by intradermal allogeneic ﬁbroblasts randomized against placebo injections. Registrars Oral Presentations (runner up for 1st prize) Australasian College of Dermatologist’s 43rd Annual Scientiﬁc Meeting, Darwin, NT, Australia.

2011 Prof Dedee F Murrell:

INVITED LECTURES

American Academy of Dermatology, New Orleans 2011 What’s New in Autoimmune Blistering Diseases (Forum)

Australia and New Zealand Cornea Society Meeting, Sydney, NSW, 17th March 2011 Blistering diseases with Ocular Manifestations.

University of Malaya, Kuala Lumpur, Malaysia, Grand Rounds, April 11th, 2011 Autoimmune Blistering Diseases – what’s new?

Hospital of Kuala Lumpur, Malaysia, Dept of Dermatology, April 13th, 2011 Update on new therapies for Epidermolysis Bullosa

19 International Leadership Forum, Women’s Dermatologic Society, Seoul, Korea, May 2011 Chair of Symposium Lecture: Success in Dermatology Migration

World Congress of Dermatology, Seoul, Korea May 2011 CoChair, Symposium on Epidermolysis Bullosa; speaker on Cell Therapy in EB Chair, Workshop on Databases in Dermatology; speaker on Australasian EB Registry Speaker, QOL in Blistering Disorders, Workshop on Scoring Systems Speaker, What’s New in Epidermolysis Bullosa

Yale University School of Medicine, New Haven, CT, USA, 8th June 2011 Cell therapies for Epidermolysis Bullosa (invited by Jean Bolognia)

Westmead Hospital, Sydney, 14th Sept 2011, Symposium on Autoimmune Blistering Diseases Outcome measures & deﬁnitions for AIBD

Malaysian Dermatology Society 2011, Port Dickson, Malaysia, Sept 22-25th, 2011 2011 Ganesapillai Memorial lecture: Nonsurgical approaches to skin cancer Workshop on Dermoscopy (2.5hrs with hands on experience) What’s new in autoimmune blistering diseases What’s new in translational research in EB

International Islamic University Malaysia, Kuantan, Malaysia, Oct 1st 2011 Pattern recognition in the diagnosis of skin diseases.

University of Putra Malaya, Kuala Lumpur, Malaysia, Oct 7th 2011 Academic Dermatology- the Female Perspective.

European Academy of Dermatovenereology, Lisbon October 2011 President’s Symposium, Invited Speaker, What’s new in Translational Therapy for EB

University of Barcelona Medical School, Hospital Clinic, Dept of Dermatology, Barcelona Evidence based treatment of pemphigus & pemphigoid (invitation Dr Jose Mascaro Jr) Hospital San Pau, Barcelona, Spain, Oct 2011 Genotype to phenotype in Epidermolysis Bullosa (invitation of Dr Eulalia Baselga)

Royal Brisbane Hospital, Brisbane, QLD, Nov 16th 2011 – visiting Professor What’s new in Epidermolysis Bullosa.

20 CONFERENCE CONTRIBUTIONS

American Academy of Dermatology, New Orleans, February 3-8th Chair, Symposium on Autoimmune Blistering Diseases Speaker, Forum on Autoimmune Diseases. Co-Chair, Consensus meeting for Bullous Pemphigoid Vice Chair, AAD World Congress Task Fund meeting Chair, WDS International Affairs Committee meeting Chair, ISD Maria Duran Committee meeting

Australasian College of Dermatologists Annual Meeting, Perth, May 2011 Photovalidation of severity scores for pemphigus 14 total posters/papers

Philippine Dermatologic Society Annual Meeting with the WDS, Manila, May 2011 Invited speaker: Atopic dermatitis and psoriasis in teenagers – special considerations in management Lupus- considerations for women

World Congress of Dermatology, Seoul, South Korea, May 2011 International Leadership Forum, Women’s Dermatologic Society Program Chair Success in Dermatology Migration Invited Co-Chair, Workshop on Epidermolysis Bullosa; speaker on cell therapy Invited Chair, Workshop on Databases in Dermatology: speaker on EB Registries Invited Speaker, Workshop on Autoimmunity, Speaker on Quality of Life in AIBD Invited Speaker, What’s New in Hereditary Dermatoses – Epidermolysis Bullosa Chair, ﬁrst international deﬁnitions meeting for MMP

European Academy of Dermatology, Lisbon, Portugal, October. Chair, Symposium on Genetic blistering disorders and Genodermatoses. Paper: Cell therapies for Epidermolysis Bullosa Invited Speaker, President’s Symposium Novel speciﬁc therapies for Epidermolysis Bullosa Chair, 2nd Consensus meeting on Mucous Membrane Pemphigoid Women’s Dermatologic Society – CoChair of Rose Parade of Cases International Society for Dermatology – Presentation on Upcoming Conferences closing remarks of session

Autoimmune Blistering Diseases, What’s New, Zagreb, Croatia, October 29-30th Presentation of Maria Duran medal to Prof Jasna Lipozencic Quality of life in AIBD Scoring systems for blistering diseases

International Leadership Forum, Women’s Dermatology Society, for World Congress of Dermatology, Seoul, Korea: 20 international speakers.

Blistering Diseases of the Newborn Seminar, European Academy of Dermatovenereology, Lisbon, Portugal. 5 international speakers.

21 OTHER INTERNATIONAL PRESENTATIONS BY RESEARCH FELLOWS & STUDENTS

Dept of Dermatology at St George- 13 abstracts at the Australasian College of Dermatologists Annual meeting in Perth, May 2011, including oral paper by ILP students Minmin Li. Two presentations at the Australasian Society for Derm Research – oral by ILP student Andrew Dermawan. One paper at the European Society for Dermatological Research – travel award to Dr Deshan Sebaratnam to present our QOL in AIBD project. Three oral papers at the World Congress of Dermatology, Korea (Dr Intong and 2 ILP students, Min- Hee Kim and Shelley Hwang)

COMMUNITY ENGAGEMENT

Australasian Blistering Diseases Foundation – Patient support group meetings organized on St George Campus and fundraising to support research into lifethreatening blistering diseases.

DebRA Australia – annual meeting on Sunshine Coast for patients – Prof Murrell gave talks and Lesley Rhodes, Minhee Kim and Lesley Rhodes volunteered to assist EB patients attending.

Butterﬂy Day – fundraising for DebRA – organized by Lesley Rhodes in front lobby of St George Hospital.

22 EMERGENCY DEPARTMENT

DEPARTMENTAL STAFF*

Head of Department Trevor Chan MB ChB, Dip Paeds, FACEM (St George Hospital) Michael Golding MBBS, FACEM, Master in Public Health (The Sutherland Hospital)

Senior Medical Staff Staff Specialists St George Hospital Peter Grant BSc (Hons) MBBS , FACEM Donovan Dwyer MBBCh, DCH, DipPEC, FACEM Megan Cox B. Med, Masters International Public Health, FACEM Stephen Asha BSc (Med) MBBS (Hons), FACEM Geoff Mifsud BSc (Med) MBBS, FACEM Alex Tzannes BSc (Med) MBBS (Hons), FACEM Jacqueline Weeden MBBS (Hons), Dip Paeds (UNSW), FACEM Stephen Korbel BSc (Med) MBBS (Hons), FACEM Natasha Ching BSc (Med), FACEM Sarah Coombes BSc, MBBS, Dip IMC, FRCS, FCEM, FACEM Carissa Oh BSc (Med) MBBS, FACEM Simone Moore MBBS (Hons), FACEM Jeffery Lui MBBS, FACEM Adam Chan MBBS (Hon), Grad dip Couns, FACEM

Visiting Medical Ofﬁcers Tamara Pollock MBBS, FACEM Lee Fineberg BS, MD, FACEP, FACEM

Staff Specialists The Sutherland Hospital David Mah MBBS, FACEM, Master in Health Administration Jeffrey Lui MBBS, FACEM John Raftos MBBS, FACEM Peter Wyllie MBBS, FACEM Gina Watkins MBBS, FACEM Andrea Bell MBBS, Dip Paeds, FACEM

TSH Visiting Medical Ofﬁcers John Mackenzie MBBS, FACEM Javad Najaﬁ MBBS, FACEM

23 Research Staff Senior research staff Stephen Asha, Director of Emergency Medicine Research. BSc MBBS FACEM Conjoint Lecturer, UNSW

Nursing & Allied Health research staff Leanne Horvat, Clinical Nurse Consultant | RN, RM Cert Emerg, Dip Mid, MN NursPrac Conjoint Lecturer, University of Newcastle | Clinical Lecturer, Sydney University. Belinda Kennedy, Nurse Educator | RN | Cert Emerg Kate Jarrett, Clinical Nurse Educator | RN | MN Emerg

RESEARCH GRANTS#

Category II - Other competitive grants:

Ministerial Taskforce on Emergency Care ‘taking the pressure of public hospitals’ project grants. $146,000, 2011-2012 ﬁnancial year, providing funding for three projects:

Impact of an Integrated Point of Care Testing service in the Emergency Department: a randomised trial Asha S, Chan A, Honeyman D

Economic evaluation of an integrated point of care testing service in the emergency department. Asha S, Chan A.

Three month outcome of patients with suspected acute coronary syndrome using point of care troponin testing compared with laboratory based troponin testing: a randomised trial. Asha S, Chan A, Weaver J, Cooke A.

Category III – Industry and other research funding:

NSW Health Nursing and Midwifery Ofﬁce Innovations Scholarship. Horvat L, Fry, M. Fong, J. & Plowes J. “To explore the nursing assessment & initial management of septic patients in the Emergency Department. Awarded $14,956.05 Financial year 2010-2011. (Investigator Initiated)

24 RESEARCH PROJECTS IN PROGRESS

Title Investigators

Gallagher R. Chenoweth L. Fry M. Stein-Parbury J. Roche M. Disler R. Care of the Older Person with Chronic Illness in the Emergency Department. Chan A. Borg A. Horvat L. (2010) University of Technology Sydney and St George Hospital. Fry M. Jarrett K. Ruperto K. Brinton J. Investigation of the Clinical Initiatives Nurse Role in the Emergency Department. Fetchett W. (2010) University of Technology Sydney. Horvat L, Fry, M. Fong, J. & Plowes J. To explore the nursing assessment & initial management of septic patients in the (2010) St George Hospital, South Eastern Emergency Department. Sydney Local Health Network and University of Technology Sydney. Clements A. Curtis K. Holzhauser K. & Evaluation of a Guideline Change: Nursing Roles in ED Trauma Resuscitation. Horvat L. (2010) St George Hospital, South Eastern Sydney Local Health Network. Fahy K. Warner A. Saxton, A. Indig D. Women’s Experience of Early Pregnancy Care in Five Emergency Departments in Horvat, L. (2010) Clinical Excellence Hunter New England Area Health Service.. Commission.

Impact of an Integrated Point of Care Testing service in the Emergency Asha S, Chan A, Honeyman D Department: a randomised trial.

Economic evaluation of an integrated point of care testing service in the Asha S, Chan A. emergency department.

Three month outcome of patients with suspected acute coronary syndrome using point of care troponin testing compared with laboratory based troponin Asha S, Chan A, Weaver J, Cooke A. testing: a randomised trial. Comparison of radiation exposure of trauma patients from diagnostic radiology Asha S. Curtis K. Grant N. Taylor C. Lo S. procedures before and after the introduction of a ‘panscan’ protocol. Accepted Compagnoni K. St George Hospital. for publication in Emergency Medicine Australasia.

Does the use of patient controlled analgesia in blunt thoracic trauma reduce Asha S. Curtis K. Kwok A. complications and improve outcome? St George Hospital

Asha S. Kerr A. Jones K. Misir S. Benztropine for the relief of acute non-traumatic neck pain – a randomised trial. St George and Ryde Hospitals.

Prehospital CPAP for acute cardiogenic pulmonary oedema: a randomised Middleton P. Ambulance service of NSW controlled trial comparing standard care plus CPAP to standard care alone. and St George Hospital.

Nichols M, Acker J, Bendall J. Asha S. Incidence of Unrecognised Oesophageal Intubation by Paramedics. Ambulance service of NSW and St George Hospital.

Patient characteristics inﬂuencing GP follow up from the Emergency Department. Quereshi R. Asha S. St George Hospital

Elderly patients with traumatic subdural haemorrhages: a comparison of Asha S, Keady J, Curtis K, Kohan S. outcomes between those on anticoagulants at the time of injury and those not.

25 ORIGINAL PEER-REVIEWED PUBLICATIONS

Margaret Fry, Jacqueline Fong, Stephen Asha, Glenn Arendts. A 12-month evaluation of the impact of transitional emergency nurse practitioners in one metropolitan emergency department. AENJ. Available online 9 November 2010.

Blunt cardiac injury as a result of a motor vehicle collision: A case study. Kate Curtis, Stephen Asha. AENJ. 2010; 13(4): 124-129

Asha SE, Titmuss K, Black D. No effect of time of day at presentation to the emergency department on the outcome of patients who are admitted to the intensive care unit. Emerg Med Australas. 2011 Feb; 23(1): 33-8.

Involuntary psychiatric attendances at an Australasian emergency department: A comparison of police and health-care worker initiated presentations (pages 593–599). Peter Llewellin, Glenn Arendts, Jacqueline Weeden and Andrew Pethebridge. Emerg Med Australas. 2011 Oct; 23(5): 593–599.

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews) None reported.

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

To explore the nursing assessment and initial management of septic patients in the Emergency Department. Horvat L., Fry M, Fong J, Plowes, J. Presented by Horvat L.. 9th International Conference for Emergency Nurses. Adelaide Convention Centre, South Australia. 1st October 2011

Women’s experience of early pregnancy care in ﬁve emergency departments in Hunter new England Area Health Service. Horvat, L. Warner A. Saxton A. Fahy K. & Indig, D. Presented by Horvat L.. 9th International Conference for Emergency Nurses. Adelaide Convention Centre, South Australia. 30th September 2011.

Obstetric Emergencies. Presented by Horvat L. Institute of Trauma and Injury Management (ITIM) Trauma on the Coast. The Mantra Ettalong Beach. 17th September 2010.

Critical Care Conference in the Vineyards (Convener, Co-Chairperson Horvat, L.) Lindemans Estate, Hunter Valley Pokolbin. 22nd & 23rd April 2010.

Comparison of radiation exposure of trauma patients from diagnostic radiology procedures before and after the introduction of a ‘panscan’ protocol. Asha S. Curtis K. Grant N. Taylor C. Lo S. Compagnoni K. Presented by Grant N. ACEM annual scientiﬁc meeting, Canberra, ACT Nov 2010.

26 COMMUNITY ENGAGEMENT

First Aid Skills Training (FAST) Project – Ajami, A & Kennedy B. Provision of education and training, to enable CALD groups to take appropriate action in the event of a life threatening emergency. Multicultural Health Service Cultural Diversity Health Enhancement Grant Program 2010-2011. Awarded grant $8 473

27 DEPARTMENT OF ENDOCRINOLOGY

DEPARTMENTAL STAFF*

Head of Department Associate Professor Tony O’Sullivan MBBS, FRACP, MD, MHPEd

Senior Medical Staff Staff specialists Associate Professor Terrance Diamond MB, BCh, MRCP, FRACP Dr Peter Rohl MBBS, FRACP

Junior medical staff Advanced trainees: Dr Naswrin Noir 2010 Dr Alice Tang 2011

Research Staff Senior research staff Terry Golombick

Research assistants

Research students

Nursing & Allied Health research staff

RESEARCH GRANTS#

Category I - Nationally Competitive Grants:

None reported.

Category II - Other competitive grants:

2010 UNSW Learning and Teaching Development Grant Application - $66,500. Investigators McNeil P, Jones P, Scicluna H, O’Sullivan AJ, and Harris P. “Review and alignment of assessments with graduate capability outcomes”.

28 2011 UNSW Strategic Learning and Teaching Development Fund Grant Application - $25,000. Investigators Cole A, Scicluna H, O’Sullivan AJ, Harris P, Velan G. “Graduate capabilities and the selection process into medical school: can it predict student performance and maintain diversity?”

2011 UNSW Strategic Learning and Teaching Development Fund Grant Application - $10,000. Investigators Balasooriya C, Tyalor S, Tancred E, Thompson R, O’Sullivan AJ, Olupeliyawa A. “Assessment and development of teamwork across all Phases of the UNSW Medicine Program?”

Category III – Industry and other research funding

None reported.

RESEARCH PROJECTS IN PROGRESS

Title Investigators

Changes in body composition and energy metabolism during pregnancy: AJ O’Sullivan, Jack Morris predictive of preeclampsia and gestational diabetes mellitus?

The relationship between vitamin D deﬁciency and gestational diabetes during C White, AJ O’Sullivan, pregnancy.

ORIGINAL PEER-REVIEWED PUBLICATIONS

Clark WA, Diamond TH, McNeil HP, Gonski PN, Schlaphoff GP, Rouse JC. Vertebroplasty for painful acute osteoporotic vertebral fractures. Med J Aust 2010; 192: 334-337.

Diamond T, Golombick T, Manoharan A. Vitamin D status may effect the skeletal complications of multiple myeloma. Am J Hematol 2010; 85: 302-303.

Lim DCE, Chen W, Cheng L, Xue CC, Wong FWS, O’Sullivan AJ, Liu JP. Acupuncture for polycystic ovarian syndrome. Cochrane Database of Systematic Reviews, 2010; article number DL1520.

Cheema B, Abas H, Smith B, O’Sullivan AJ, Chan M, Patwardhan A, Kelly J, Gillin A, Pang G, Lloyd B, Berger K, Baune BT, Fiatarone Singh M. Investigation of skeletal muscle quantity and quality in end- stage renal disease. Nephrology 2010; 15: 454-463.

Lim CED, Cheng NCL, Chow YKM, Wong WSF, O’Sullivan AJ. Complimentary and alternative medicine for the metabolic syndrome. Journal of the Australian Traditional-Medicine Society 2010; 16: 209-216.

29 Diamond T, White C. The fracture cascade: managing individuals who continue to fracture on osteoporotic therapies. Medicine Today 2010; 11: 56-66.

Cheema B, Abas H, Smith B, O’Sullivan AJ, Chan M, Patwardhan A, Kelly J, Gillin A, Pang G, Lloyd B, Berger K, Baune BT, Fiatarone Singh M. Effect of resistance training on circulating cytokines: a randomised controlled trial. European Journal of Applied Physiology 2011; 111: 1437-1445.

Diamond T, Golombick T, Manoharan A Kwan Y, Bryant C. The impact of osteoporosis (as measured by lumbar spine quantitative computed tomography) on disease activity and survival in myeloma patients: A 13 year prospective study. Am J Hematol 2011; 86: 617-619.

O’Sullivan AJ, Harris P, Hughes CS, Toohey SM, Balasooriya C, Velan G, Kumar RK, McNeil HP. Linking assessment to undergraduate medical student capabilities through portfolio examination. Assessment and Evaluation in Higher Education, published on line March 18, 2011.

Wu B, O’Sullivan AJ. Sex differences in energy metabolism need to be considered with lifestyle modiﬁcations in humans. Journal of Human Nutrition and Metabolism, published on line July 2, 2011.

Wong LY, Campell P, Usui T, O’Sullivan AJ. Symptomatic massive bilateral myelolipoma in a patient with con-genital adrenal hyperplasia – aetiology unlikely to be related to ACTH stimulation. Journal of Endocrinology and Metabolism, published online, Vol 1, No 2 June 2011

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

None reported.

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

Jones PD, O’Sullivan AJ, Hughes C, Harris P. Validity of a summative portfolio. 7th International Medical Education Conference, Kuala Lumpur, Malaysia, 2010.

O’Sullivan AJ, Howes A, Miles S, Harris P, Hughes C, Jones P, Scicluna H, Leinster S. Summative portfolio assessment: A method to assess reﬂective practice in medical students. Annual Meeting for the Association of Medical Education, Edinburgh, Scotland 2010, Oral No 2H2.

O’Sullivan AJ, Howes A, Miles S, Leinster S. Are portfolios a valid method of assessing professionalism? A study from two medical schools. Frontiers in Medical and Health Sciences Education, Hong Kong University, 2010, Oral OP1.

O’Sullivan AJ. “Assessment of Professionalism”. Workshop on Professionalism. 2010 International Medical University, Kuala Lumpur, Malaysia.

30 O’Sullivan AJ “Assessment of portfolios in medical students”. 2010 University of East Anglia, School of Medicine, Norwich, UK.

Golombick T, Diamond T. Role of Curcumin in Patients with Monoclonal Gammopathy of Undeﬁned Signiﬁcance. Annual Meeting of IBMS, Cancer and Bone, Sydney, Australia 2010.

Diamond T, Golombick T, Manoharan A. Vitamin D status may effect skeletal complications of multiple myeloma. St George Hospital Annual Symposium, Sydney, Australia 2010 (Award: First Prize).

Diamond T, Golombick T, Manoharan A. Vitamin D status may effect skeletal complications of multiple myeloma. NHMRC Research Forum. Vitamin D Workshop. Melbourne 2010.

Golombick T, Diamond T, Manoharan A and Ramakrishna R. Monoclonal Gammopathy of Undetermined Signiﬁcance (MGUS), Smoldering Multiple Myeloma (SMM) and Curcumin: A Randomised, Double-blind Placebo-Controlled Cross-over 4g study and an Open-label 8g Extension Study. Eighth International Conference of the Society for Integrative Oncology. Cleveland, Ohio, USA, 2011.

Diamond T, Golombick T and Wong Y. The effect of oral cholecalciferol 2000 IU versus 5000 IU on serum vitamin D, PTH, bone and muscle strength in patients with vitamin D deﬁciency. ANZ Bone Mineral Society Annual Scientiﬁc Meeting, Gold Coast, Australia 2011.

Chen KK, Han X, McShane M, Hussain Z, Chan YF, Ling BY, White CP, O’Sullivan AJ. Low vitamin D level at the time of ﬁrst trimester is associated with an increased risk of gestational diabetes mellitus. 6th International Symposium on Diabetes and Pregnancy, Slazburg, Austria 2011, No. 155.

Chen KK, Han X, Hussain Z, Chan YF, White CP, O’Sullivan AJ. Low adiponectin level at the time of oral glucose tolerance testing is associated with gestational diabetes mellitus. 6th International Symposium on Diabetes and Pregnancy, Slazburg, Austria 2011, 156.

Fiatarone-Singh M, Mavros Y, Simar D, Anderberg K, Kay M, Wang Y, Singh N, O’Sullivan AJ. Glucose Transporter-4 Expression in Monocytes is Correlated to Indices of Insulin Resistance in Older Adults with Type 2 Diabetes. The Annual Meeting of the American Gerontological Society. 2011.

Olupeliyawa.A, O’Sullivan AJ, Hughes CS, Balasooriya C. Preparing medical students for clinical competence as interns: development of a work-based assessment to drive learning. The Annual Meeting of the Australian and New Zealand Association for Health Professionals Education, Alice Springs 2011.

31 COMMUNITY ENGAGEMENT

The Diabetes Group Report The Diabetes Education Centre continues to provide a service to the St George Division of General Practice for a group education program.

The target group suffers from insulin resistance, impaired fasting glucose, Type 2 patients. Referral sources included: Diabetes Education Centre Diabetes Clinic Nutrition department Other Allied Health General Practitioners

Exclusions: Non English speaking and children.

Venue: Division of General Practice

The program consisted: Session 1 Understanding your condition Session 2 Nutrition Session 3 Podiatry Session 4 Ophthalmology Session 5 Nutrition Session 6 Physical Activity

Each session, except session 1, contain a physical activity component

The session given by the educator includes the following topics: 1. Healthy eating (brief as covered by dietitian) 2. Being Active (brief as covered by exercise physiologist) 3. Monitoring 4. Taking Medication 5. Problem Solving 6. Healthy Coping 7. Reducing risks

Since commencement of the Group 244 participants have attended groups. The majority of referrals have been from The Diabetes Education Centre.

Chinese Speaking Gestational Diabetes Mellitus Clinic. Introduction of a weekly block booking Chinese Interpreter supported Chinese speaking Gestational Diabetes review clinic. This clinic has improved access for these women and provided opportunities for regular review and psychosocial support.

32 DEPARTMENT OF GASTROENTEROLOGY AND HEPATOLOGY

DEPARTMENTAL STAFF

Head of Department A/Prof Amany Zekry MB.BS, PhD, FRACP (Associate Professor of Medicine, UNSW)

Senior Consultant Staff Prof Ian Cook MB.BS, MD(Syd), FRACP (Conjoint Professor of Medicine, UNSW) Dr Philip Craig MB.BS, PhD, FRACP (Visiting Medical Ofﬁcer) Dr John Freiman MB.ChB, PhD, FRACP (Visiting Medical Ofﬁcer) Prof Michael Grimm MB.BS, PhD, FRACP (Professor of Medicine, UNSW; Head Clinical School) Dr Gokulan Paven MB.BS, FRACP (Staff Specialist; from Jan 2011)

Clinical Associates Dr Marianne Giurgis MB.BS, FRACP (Mar 2010 – Jan 2011)

Junior Medical Staff Dr Vipul Aggarwal MB.BS, MD(Gujarat) (Advanced Trainee in Gastroenterology; 2010) Dr Ricardo Jurawan MB.BS (Advanced Trainee in Gastroenterology; 2010) Dr Vivek Kumbhari MB.ChB (Advanced Trainee in Gastroenterology; Jan 2010 – Dec 2011) Dr Sudarshan Paramsothy MB, BS (Advanced Trainee in Gastroenterology; 2011) Dr Simon Ghaly MB.BS (Advanced Trainee in Gastroenterology; 2011)

Research Staff Senior Research Staff Dr Phil Dinning BSc, PhD (Senior Research Fellow, UNSW) Dr Michal Szczesniak BSc, PhD (Post-Doctoral Research Fellow, UNSW) Dr Rajkumar Cheluvappa MB BS, PhD (Post-doctoral Research Fellow, UNSW; 2010 - 2011) Dr Alissa Walsh MB BS, FRACP (National Institute of Clinical Studies, NHMRC Fellow; 2010 – Apr 2011) Dr Clovis Palmer, PhD (Post-doctoral research fellow; 2010)

Gastrointestinal Motility Laboratory Supervisor Mr Sergio Fuentealba BSc (to Sept 2010) Ms Grace Zhang MSc (Mar 2011 - )

Research Assistants Ms Koko Bu MB.BS, M.Med (USYD), Research Assistant (SGH, UNSW) Ms Linda Hunt BSc Mr Lukasz Wiklendt B.Comp.Sc (Hons) (2010) Ms Hye Jee Jung (BSc)

33 Research Students Ms Annie Luo BSc (Hons) (PhD student) Dr Greta Lee MB.BS, FRACP (PhD student, 2010) Ms Danica Martiniz (Honours Student; 2010) Ms Vicki Patton RN (PhD Candidate, co-supervisor, Dr Phil Dinning) Ms Suzanne Polis (PhD Candidate) Benny Bahrudin PhD UNSW Marianne Guirgis- MSc UNSW (2010) Vipul Aggarwell- MSc UNSW (2010)

Nursing & Allied Health staff Ms Lisa Dowdell Clinical Nurse Specialist: Grad Dip of Nursing (UTAS) Ms Suzanne Polis, Clinical Nurse Consultant BN (USyd), MPH (research), Casual Lecturer, Faculty of Nursing, Midwifery and Child Health, UTS Ms Christine Janssen Social worker BA, BSW (Hons I) (USYD) Ms Amber Raco Clinical Dietitian BSc (Exercise Science & Nutrition) and MSc (Nutrition & Dietetics) (2010). Ms Elizabeth Jacques RN: B.N (UTS), MPH (Wollongong) Ms Rachel Pons, Clinical Dietician: BND (Hons I, UoW), APD (2011)

RESEARCH GRANTS#

Category I - Nationally Competitive Grants:

NHMRC project grant: Grimm MC, Lloyd AR. The appendix in intestinal immunity and in inﬂammatory bowel disease (ID: 455466). ($447,000; 2007-2010)

NHMRC project grant: Tedla N, Grimm MC, Geczy C. Regulation of monocyte and macrophage functions by leucocyte immunoglobulin-like receptors (LILRs)-A5, B1 and B4: roles in intestinal immune tolerance and inﬂammation (ID: 568771). ($495,000; 2009-2011)

NHMRC Project Grant: Dinning PG, Cook IJ, Arkwright J, Scott M, Lubowski DZ, Jones M. Development of diagnostic tools to characterize predictors of therapeutic outcome in severe constipation. (ID: 630502). ($418,500; 2010 – 2012).

NHMRC Project Grant: Clark K, Currow D, Talley N, Dinning PG, Lam L, Davidson P, Agar M, Shelby-James T, Phillips J. Does a structured approach to diagnosing and managing constipation reduce symptom severity for palliative care patients? (ID1010096). ($714,120; 2011 – 2013).

NHMRC Program Grant: Cooper DA, Beard M, Dore G, Emery S, French M, Kelleher A, Kent S, Lloyd A, Purcell D (Zekry A: Associate Investigator). HIV & HCV Vaccines and Immunopathogenesis (ID: 510488). ($17,734,213.33; 2009-2013)

NHMRC Equipment Grant St George Clinical School: Grimm MC. Sorvall Ultracentrifuge ($136,290; 2010)

34 NHMRC Equipment Grant St George Clinical School: Grimm MC. Akta Avant 150 FPLC ($153,955; 2011)

Category II - Other competitive grants:

Olympus Australia (investigator initiated): Craig PI: The role of peroral balloon-assisted cholangioscopy to assess biliary disease. ($20,000; 2011-2012).

Mavis Egan Memorial Crohn’s Disease Research Fund: Grimm MC. Immunopathogenesis of Crohn’s disease ($338,000; 2010-2012)

Cancer Institute of NSW, Research Innovation Grant: Cook IJ, Graham P. Predicting dysphagia- related complications and improving outcomes in patients treated with head and neck radiotherapy. ($48,000; 2011).

University of New South Wales, Post Doctoral Research Grant. Szczesniak MM. Development and validation of novel ﬁbre-optic strain sensors for evaluation of longitudinal shortening of the human oesophagus ( $10,000, 2011)

Flinders Medical Centre Foundation Grant Round. Deﬁning the mechanistic control of colonic motility. Dinning PG. ($16,000; 2011)

School of Nursing (Flinders Hospital) and Midwifery Partnership Research Grants. P Lynn, J Paterson, G Saccone, P Bampton, B Southwell, PG Dinning. Transcutaneous electrical stimulation for intractable constipation in young and older adults. ($49,014; 2011)

Category III – Industry and other research funding:

Medtronic US, Grant in Aid (Investigator initiated): Cook IJ, Dinning PG. Randomised, cross-over efﬁcacy trial of sacral nerve stimulation in treatment of slow transit constipation. ($900,00; 2007 – 2011)

Medtronic Australia, Grant in Aid (Investigator initiated): Cook IJ, Dinning PG. RCT sacral nerve stimulation in treatment of slow transit constipation. ($64,000; 2010 - 2011)

Olympus Australia (Investigator initiated): Aggarwal V & Craig PI: The role of wireless capsule endoscopy in Crohn’s disease patients to assess clinical remissions and predict future relapses. ($70,000; 2009-2011)

Cultural Diversity Health Enhancement Grant. Janssen C. Partnerships in Practice – Improving access for CALD communities to testing and treatment of HCV and HBV. ($6,740; 2010 – 2012)

35 RESEARCH PROJECTS IN PROGRESS (2010 & 2011)

The role of wireless capsule endoscopy in Crohn’s disease patients to assess clinical remissions and predict future relapses. Aggarwal V, Connor S, Scott D, Grimm MC, Craig PI.

Can a prototype contrast capsule enhance capsule endoscopy image quality? Aggarwal V, Craig PI

Balloon-assisted direct peroral cholangioscopy using an ultraslim gastroscope. Lim P, Aggarwal V, Craig PI.

Safety and outcomes following treatment of oesophageal achalasia. Kumbahri V, Fuentealba S, Elliott T, Wu PI, Metz A, Cook IJ.

Biomechanics of the pharyngeal swallow following laryngectomy and evaluation of safety and efﬁcacy of cricopharyngeal dilatation. Szczesniak MM, MacLean J, Paramsothy S, Cook IJ.

Predicting dysphagia-related complications and improving outcomes in head and neck radiotherapy patients. Szczesniak MM, MacLean J, Zhang T, Graham P, Cook IJ.

Modulation of oesophageal afferent pathways by 5-HT3 receptor inhibition. Szczesniak MM, Fuentealba SE, Zhang T, Cook IJ.

Development and validation of novel ﬁbreoptic strain sensors for evaluation of longitudinal shortening of the human oesophagus during swallowing, Szczesniak MM, Arkwright J.

Relationships among bowel symptoms, colonic transit and colonic motor activity. Dinning PG, Talley NJ, Jones M, Fuentealba S, Cook IJ.

Identiﬁcation of potential manometric biomarkers in slow transit constipation. Dinning PG, Arkwright J, Scott M, Lubowski DZ, Cook IJ.

Evaluation of the inﬂuence of sacral nerve stimulation on colonic propagating motor patterns. Dinning PD, Hunt L, Fuentealba S, Lubowski DZ, Arkwright J, Scott M, Cook IJ.

Randomised controlled trial of the efﬁcacy of sacral nerve stimulation in severe slow transit constipation (Investigator initiated). Dinning PD, Hunt L, Fuentealba S, Lubowski DZ, Cook IJ.

Impact of recording technique, catheter design and experimental conditions on human colonic motor patterns. Dinning PD, Hunt L, Fuentealba S, Lubowski DZ, Arkwright J, Scott M, Cook IJ.

The role of descending inhibition in transport of ﬂuid content in the colon. Sinnott MD, Cleary PW, Wang CX, Arkwright JW, Dinning PG.

Three dimensional visualisation of colonic manometry data. Davidson JB, O’Grady G, Pullan AJ, Dinning PG.

36 Relating gut movement and intraluminal manometry in the isolated rabbit small intestine. Dinning PG, Costa M, Arkwright JW, Wiklendt L, Hennig G, Brookes SJ, Spencer NJ.

The potential impact of laxative use on stool form and frequency in patients with slow transit constipation. Dinning PG, Jones M, Hunt L, Lubowski DZ, Kalantar J, Cook IJ.

A ﬁbre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract. Arkwright JW, Blenman NG, Underhill ID, Maunder SA, Spencer NJ, Costa M, Brooks SJ, Szczesniak MM, Dinning PG.

Automated analysis of high resolution colonic manometry. Wiklendt L, Dinning PG.

Role of the appendix in intestinal immunity. Grimm MC, Lloyd AR, Eri R

Opportunistic infection in inﬂammatory bowel disease: altering physician behaviour. Walsh A, Grimm MC

The contribution of leucocyte immunoglobulin-like receptors to maintenance of intestinal immune homeostasis. Tedla N, Grimm MC, Lee G, Geczy C.

The role of mast cell speciﬁc serine proteases in inﬂammatory bowel disease in mice and humans. Krilis S, Stephens R, Grimm MC

Campylobacter concisus and its role in the aetiology and pathogenesis of early inﬂammatory bowel disease. Zhang L, Mitchell H, Day AS, Grimm MC

Measuring the medical student experience. Grimm MC, Boyle P, McNeil HP.

Empathy as a function of clinical exposure. Handford C, Grimm MC, Vollmer-Conna U.

The case for case method teaching in clinical education. Grimm MC, McNeil HP.

Role of miRNA 135a in regulating hepatic inﬂammation and steatosis in chronic hepatitis C and non-alcoholic fatty liver disease- Palmer C, Lloyd A and Zekry A

Effect of suppressor of cytokine 3 on the anti-HCV immune responses in obese subjects with chronic hepatitis C virus infection- Martinez D, Palmer C, Simari D , Lloyd A and Zekry A

Altered glucose metabolism within T cells adversely affects CD8 T cell function in chronic hepatitis C virus infection.Baharuddin B, Simar D, Palmer C, Lloyd A and Zekry A

Regulation of T cell recruitment and inﬂammation in the HIV/HCV co-infected liver. Nguyen N, Zekry A and Lloyd A

Barriers to access of health services in the migrant population with viral hepatitis. Guriguis M, Zekry A

37 Viral Hepatitis related HCC: Can nutritional supplements improve clinical outcome and quality of life? Raco,A. Polis, S. Bell, J. Zekry, A.

Assessing malnutrition prevalence of liver disease patients at SGH Liver Clinic and development of Nutrition screening, assessment and feedback forms for effective nutritional management of these patients. Raco, A, Bell, J

Evaluating the surveillance systems and care provided to patients attending the HCC clinic during 2010. Polis, S. Liauw, W, Freiman, J. Chu, F. Zekry, A.

Factors determining adherence to therapy for chronic hepatitis B virus infection. Polis S, Zekry A and Maher L

GS-AU-103-0185 Study of Acquired Viral Mutations in Chronic Hepatitis B Patients on Antihepadnaviral Therapy (CHARM)

A Phase IV, Randomised, Multicentre, Efﬁcacy and Safety Study Examining the Effect of Induction Dosing with the combination of peginterferon Alfa-2a and Ribavirin in Patients with Chronic Hepatitis C Infected with Hepatitis C Genotype 1. [CHARIOT STUDY]

Phase IV Study of Tailored Therapy with PEG INTERFERON ALFA 2B and Ribavirin for Patients with Genotype 3 and High Viral Load Genotype 3 Extended Treatment for HCV (GET-C STUDY)

A Multi-Center, Randomized, Double-Blind, Active-Control, 96 Week, Phase III Trial of the Efﬁcacy and Safety of Clevudine Compared with Adefovir at Weeks 48 and 96 in Nucleoside Treatment- Naïve Patients with HBeAg Positive/Negative Chronic Hepatitis due to Hepatitis B Virus

A1463111: A Comparative Study of Entecavir versus Adefovir plus Lamivudine versus Combination Entecavir plus Adefovir in Lamivudine-Resistant Chronic Hepatitis B Subjects: The DEFINE Study.

CRAD00102301 – A randomised phase III, double-blind, placebo-controlled, multi-centre study to evaluate the efﬁcacy and safety of everolimus (RAD001) in adult patients with advanced Hepatocellular Carcinoma after failure of sorafenib treatment – The EVOLVE-1 Study

IMCL CP12-0919 – A Multicentre, Randomised, Double-blind, Phase 3 Study of Ramucirumab (IMC- 1121B) Drug Product and Best Supportive Care (BSC) versus Placebo and BSC as Second-line Treatment in Patients with Hepatocellular Carcinoma Following First-line Therapy with Sorafenib.

CDEB025A2211 – A multicentre, randomised , open label, parallel-group, phase IIB study on the efﬁcacy and safety of oral regimens of DEB025 alone or in combination with ribavirn versus Standard of Care ( peg-IFN alfa-2a plus ribavirin) in treatment naïve hepatitis C genotype 2 and 3 patients.

38 DEB025A2210 - A multicentre, randomized, double-blind, placebo-controlled, parallel-group phase II study on the efﬁcacy and safety of DEB025/Alisporivir combined with peg-IFN alfa-2a and ribavirin in chronic hepatitis C genotype 1 patients who are previous peg-IFN alfa-2 plus ribavirin treatment- non-responders

Novartis DEB025A2301 - A randomized, double-blind, placebo-controlled trial of the efﬁcacy and safety of DEB025/Alisporivir in combination with standard of care in hepatitis C genotype 1 treatment naïve patients

M10-963: An Open-label, Randomised Phase 3 Study of the Efﬁcacy and Tolerability of Linifanib (ABT-869) versus Sarafenib in Subjects with Advanced Hepatocellular Carcinoma (HCC) (LIGHT study)

FISSION - A Phase 3, Multicenter, Randomized, Active-Controlled Study to Investigate the Safety and Efﬁcacy of PSI-7977 and Ribavirin for 12 Weeks Compared to Pegylated Interferon and Ribavirin for 24 Weeks in Treatment-Naïve Patients with Chronic Genotype 2 or 3 HCV Infection

GS-US-174-0149 - A Phase 4, Randomized, Open-label, Active-Controlled, Superiority Study to Evaluate the Efﬁcacy and Safety of Tenofovir Disoproxil Fumarate (TDF) in Combination with Peginterferon α-2a (Pegasys®) versus Standard of Care Tenofovir Disoproxil Fumarate Monotherapy or Peginterferon α-2a Monotherapy for 48 Weeks in Non-Cirrhotic Subjects with HBeAg-Positive or HBeAg-Negative Chronic Hepatitis B (CHB)

GS-US-248-0121 - A Phase 2 Randomized, Open-Label, Exploratory Trial of GS-5885, GS-9451 with Peginterferon Alfa 2a (PEG) and Ribavirin (RBV) in Treatment-Naïve Subjects with Chronic Genotype 1 Hepatitis C Virus Infection and IL28B CC Genotype

ORIGINAL PEER-REVIEWED PUBLICATIONS

Szczesniak MM, Williams RB, Cook IJ. Mechanisms of Esophago-Pharyngeal Acid Regurgitation in Human Subjects. PLoS ONE 2011; 6(7):e22630 (doi:10.1371/journal.pone.0022630).

Sinnott MD, Cleary PW, Arkwright JW, Wang C, Dinning PG. Investigating the relationships between peristaltic contraction and ﬂuid transport in the human colon using Smoothed Particle Hydrodynamics. Comp Bio Med. 2012. doi:10.1016/j.compbiomed.2012.01.002.

Arkwright JW, Blenman NG, Underhill ID, Maunder SA, Spencer NJ, Costa M, Brookes SJ, Szczesniak MM, Dinning PG. Measurement of muscular activity associated with peristalsis in the human gut using ﬁbre Bragg grating arrays. IEEE Sensors Journal 2012; 12(1):113-7. doi:10.1109/ JSEN.2011.2123883.

Dinning PG, Arkwright JW, Costa M, Wiklendt L, Hennig G, Brookes SJ, Spencer NJ. Temporal relationships between intraluminal manometry and gut wall movement in the isolated rabbit small intestine. Am J Physiol. 2011;300(4): G577-G585

39 Davidson J, O’Grady G, Arkwright JW, Zarate N, Scott SM, Pullan AJ, Dinning PG. Anatomical registration and three-dimensional visualization of high-resolution pan-colonic manometry recordings. Neurogastroenterol Motil 2011;23:387–e171 PMID: 21199536. doi: 10.1111/j.1365- 2982.2010.01651.x.

Dinning PG, Jones M, Hunt L, Fuentealba SE, Kalanter K, King DW, Lubowski DZ, Talley NJ, Cook IJ. Factor analysis identiﬁes subgroups of constipation. World J Gastroenterol. 2011;17(11): 1468-1474.

Dinning PG, Zarate N, Szczesniak MM, Mohammed SD, Preston SR, Fairclough PD, Lunniss PJ, Cook IJ, Scott SM. Bowel preparation affects the amplitude and spatiotemporal organization of colonic propagating sequences. Neurogastroenterol Motility 2010; 22(6):633-e176. PMID: 20180824. doi. 10.1111/j.1365-2982.2010.01480.x.

Szczesniak MM, Williams RBH, Brake HM, Maclean JC, Cole IE, Cook IJ. Upregulation of the oesophago-UES relaxation response: a possible pathophysiological mechanism in suspected reﬂux laryngitis. Neurogastroenterol Mot 2010; 22 (4): 381- 386, e89.

Dinning PG, Zarate N, Hunt LM, Fuentealba SE, Mohammed SD, Szczesniak MM, Lubowski DZ, Preston SL, Fairclough PD, Lunniss PJ, Scott SM, Cook IJ. Pancolonic spatiotemporal mapping reveals regional deﬁciencies in, and disorganisation of colonic propagating pressure waves in severe constipation. Neurogastroenterol Motil. 2010; 22- e340-e349. PMID: 20879994.doi: 10.1111/j.1365- 2982.2010.01597.x.

MacLean J, Szczesniak MM, Cotton S, Cook IJ, Perry A. Impact of a laryngectomy and surgical closure technique on swallow biomechanics and dysphagia severity. Otolaryngol Head Neck Surgery 2010;144:21-28.

Arkwright JW, Blenman NG, Underhill ID, Maunder SA, Spencer NJ, Costa M, Brooks SJ, Szczesniak MM, Dinning PG. A ﬁbre optic catheter for simultaneous measurement of longitudinal and circumferential muscular activity in the gastrointestinal tract. J Biophotonics 2011;4 (4): 244-257. PMID: 20575106. doi: 10.1002/jbio.201000056.

Boyle P, Grimm MC, McNeil HP, Scicluna H. The UNSW Medicine Student Experience Questionnaire (MedSEQ): A synopsis of its Development, Features and Utility. UNSWorks at http://handle.unsw.edu. au/1959.4/41332

Zhang L, Budiman V, Day AS, Mitchell H, Lemberg DA, Riordan SM, Grimm MC, Leach ST, Wedyan Y. Isolation and detection of Campylobacter concisus from saliva of healthy individuals and patients with inﬂammatory bowel disease. J Clin Microbiol 2010; 8(8):2965-2967

Cheluvappa R, Denning GM, Lau GW, Grimm MC, Hilmer SN, Le Couteur DG. Pathogenesis of the hyperlipidemia of Gram-negative bacterial sepsis may involve pathomorphological changes in liver sinusoidal endothelial cells. Int J Infect Dis 2010;14(10):e857-867

40 McNeil HP, Scicluna H, Boyle P, Grimm MC, Gibson KA, Jones P. Successful development of generic capabilities in an undergraduate medical education program. Higher Education Research and Development 2011: DOI:10.1080/07294360.2011.559194

Cheluvappa R, Luo AS, Palmer C, Grimm MC. Protective pathways against colitis mediated by appendicitis and appendectomy. Clin Exp Immunol 2011;165(3):393-400

Heimesaat MM, Mahendran V, Riordan SM, Grimm MC, Tran TAT, Major J, Kaakoush NO, Mitchell H, Zhang L. Prevalence of Campylobacter species in adult Crohn’s disease and the preferential colonization sites of Campylobacter species in the human intestine. PLoS ONE 2011;6(9):e25417

Krastev Y, Grimm MC, Metcalfe A. Research governance and change in research ethics practices at a major Australian university. Monash Bioethics Review 2011;29(4):16.1-16.7

Guirgis M, Yan K, Bu YM, Zekry A. A study into General Practitioners’ knowledge and amangement of viral hepatitia in the migrant population. Intern Med J. 2011. Feb 8 doi: 10.1111/j.1445- 5994.2011.02440.x. [Epub ahead of print]

Nelson DR, Benhamou Y, Chuang WL, Lawitz EJ, Rodriguez-Torres M, Flisiak R, Rasenack JW, Kryczka W, Lee CM, Bain VG, Pianko S, Patel K, Cronin PW, Pulkstenis E, Subramanian GM, McHutchison JG. Albinterferon Alfa-2b was not inferior to pegylated interferon-α in a randomized trial of patients with chronic hepatitis C virus genotype 2 or 3. Gastroenterology. 2010 Oct; 139(4):1267-76. Epub 2010 Jul 1.

Zeuzem S, Sulkowski MS, Lawitz EJ, Rustgi VK, Rodriguez-Torres M, Bacon BR, Grigorescu M, Tice AD, Lurie Y, Cianciara J, Muir AJ, Cronin PW, Pulkstenis E, Subramanian GM, McHutchison JG; ACHIEVE-1 Study Team. Zeuzem S, Sulkowski MS, Lawitz EJ, Rustgi VK, Rodriguez-Torres M, Bacon BR, Albinterferon Alfa-2b was not inferior to pegylated interferon-α in a randomized trial of patients with chronic hepatitis C virus genotype 1. Gastroenterology. 2010 Oct; 139(4):1257-66. Epub 2010 Jun 27.

Patel K, Jhaveri R, George J, Qiang G, Kenedi C, Brown K, Cates C, Zekry A, Tillmann HL, Elliott L, Kilaru R, Albrecht J, Conrad A, G McHutchison J Open-label, ascending dose, prospective cohort study evaluating the antiviral efﬁcacy of Rosuvastatin therapy in serum and lipid fractions in patients with chronic hepatitis C. J Viral Hepat. 2011 May;18(5):331-7. doi: 10.1111/j.1365- 2893.2010.01310.x.

Milner KL, van der Poorten D, Trenell M, Jenkins AB, Xu A, Smythe G, Dore GJ, Zekry A, Weltman M, Fragomeli V, George J, Chisholm DJ. Chronic hepatitis C is associated with peripheral rather than hepatic insulin resistance. Gastroenterology. 2010 ; 138(3):932-41.e1-3. Epub 2009 Dec 4.

41 OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

Dinning PG & Scott SM. Novel diagnostics and therapy of colonic motor disorders. Current opinions in pharmacology. 2011;11:624-629.

Dinning PG, diLorenzo C. Colonic dysmotility in constipation. Best Practice and Research: Clinical Gastroenterology. 2011;25(1): 89-102. PMID: 21382581

Craig PI. “Benign Biliary Strictures and Biliary Leaks”. In: Bourke M, and Norton I, Eds. Endoscopy Handbook. Gastroenterological Society of Australia & AGEA 2011

Cook IJ. Difﬁculty swallowing and pain on swallowing. In: Talley N ed. Clinical Gastroenterology. 3rd Edition. Sydney: Churchill Livingstone; 2010:15-26 (ISBN 978-0-7295-39487).

Dinning PG, Benninga MA, Southwell BR, Scott SM. Paediatric and adult colonic manometry: A tool to help unravel the pathophysiology of constipation. World J Gastroenterol 2010; 16(41): 5162-72. PMID: 21049550.

Dinning PG, Arkwright JW, Gregersen H, O’Grady G, Scott SM. Technical advances in monitoring human motility patterns. Neurogastroenterol Motil. 2010; Apr;22(4):366-80. PMID: 20377792.

Cook IJ, Brookes, SJ, Dinning PG. Sensory and Motor Function of the Colon. In: Feldman M, Friedman LS, and Brandt LJ, Eds. Sleisenger and Fordtran’s: Gastrointestinal and Liver Disease. 9th Edition. Philadelphia: Saunders; 2010: Vol 2, Ch 98; 1660-1674. ISBN:978-1-4160-6189-2.

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

Dinning PG. “Live colonic manometry: What are we looking for?” Fifth European pediatric motility symposium. Amsterdam, Netherlands, Dec 2011.

Dinning PG. “What is colonic motility really telling us?” New Advances in Gastrointestinal Motility. Auckland, Nov 2011.

Dinning PG. “The effect of subsensory and suprasensory sacral nerve stimulation upon colonic propagating pressure waves”. Australian Neuroscience Society, Auckland, Feb 2011.

Craig PI. “Stenting of chronic pancreatitis biliary strictures.” Endoscopy Forum, Tokyo, Japan, July 2011.

Craig PI. “Primary sclerosing cholangitis: Excluding cholangiocarcinoma.” Bilicon meeting, Mumbai, India, Dec 2011.

42 Craig PI. “Endoscopic Palliation: Newer stents for malignant distal bile duct strictures.” Bilicon meeting, Mumbai, India, Dec 2011.

Craig PI. “Endoscopic palliation for hilar strictures: Raising the success rate”. Bilicon meeting, Mumbai, India, Dec 2011.

Cook IJ. “Is BMI of value for predicting development of Barrett’s epithelium in GERD?” 10th World Conference of O.E.S.O., Boston, Aug 2010.

Cook IJ. “Is there a potential dose-response associated with PPIs and reduced adenocaricoma risk in Barrett’s esophagus?” 10th World Conference of O.E.S.O., Boston, Aug 2010.

Cook IJ. “Functional Heartburn”. 12th World Congress of the International Society for Diseases of the Esophagus (ISDE), Kagoshima, Japan, Sept 2010.

Dinning PG. “Sacral Nerve Stimulation, colonic motility and constipation”. European Society of Coloproctology, Sorrento, Italy, Sept 2010.

Dinning PG. Keynote Speaker: “High resolution colonic manometry: Shedding light into the dark continent”. European Society for Neurogastroenterology and Motility “Hot topics”. “Recent advances in the management of chronic constipation”, Amsterdam, Netherlands, Sept 2010.

Dinning PG. Peristalsis and propulsive movements in the gut. “Neurally mediated propulsive motor patterns in the large bowel”. Fourth Joint International Neurogastroenterology and Motility. Boston USA. Aug 2010.

Dinning PG. “Colonic high resolution manometry” American Gastroenterological Association, Digestive Diseases Week, New Orleans, USA. May 2010.

Dinning PG. “The potential impact of laxative use on stool form and frequency in patients with slow transit constipation”. American Gastroenterological Association, Digestive Diseases Week, New Orleans, USA. May 2010

Aggarwal V, Day AS, Connor S, Leach ST, Grimm MC, Craig PI. Oral presentation. “Capsule endoscopy ﬁndings in small bowel Crohn’s disease patents in clinical remission: Correlation with CDAI, fecal calprotectin”. S100A12. American Gastroenterological Association, Digestive Diseases Week, New Orleans, USA. May 2010.

Luo AS, Grimm MC. “Protective role for Th17 cells in inﬂammatory bowel disease following appendicitis induction”. American Gastroenterological Association, Digestive Diseases Week, New Orleans, USA. May 2010.

Luo AS, Ng, WSW, Cheluvappa R, Grimm MC. “Appendicitis, Protection against Colitis and the Role of Colonic Regulatory T Cells”. International Congress on Mucosal Immunology, Paris, July 2011.

43 National

Craig PI. Convenor and Key Presenter, Capsule Endoscopy Workshop (full day) Sydney, May 2011.

Craig PI. “Enteral Stenting - tips and tricks”. Challenges in Gastroenterology Conference. Melbourne, June 2011.

Dinning PG. “Physiology on Constipation and Update on New Treatments” Ninetieth National Conference on Incontinence. Alice Springs, Oct 2010.

Dinning PG. “Neuromodulation of the Gut” Annual Scientiﬁc Meeting of the Australian Chapter of the International Neuromodulation Society, Newcastle, Oct 2010.

Dinning PG. “Laxative use, pain, stool form and frequency, is there any correlation between them in patients with severe constipation?” Australian Gastroenterology Week, Gold Coast, Oct 2010.

Baharuddin B, Simar D, Palmer C, Lloyd A and Zekry A. “Altered glucose metabolism within T cells adversely affects CD8 T cell function in chronic hepatitis C virus infection.” Australasian Viral Hepatitis Conference Sept 2010 .

Janssen CJ. “What happens when treatment fails? Developing better practice models for HCV patients post treatment”. National Centre in HIV Social Research 11th Social Research Conference on HIV, Hepatitis C and Related Diseases UNSW April 2010

Polis, S. Zekry, A. Maher, L. “Adherence to HBV antiviral therapies”. National Centre in HIV Social Research 11th Social Research Conference HIV, Hepatitis C and Related Diseases UNSW April 2010

Janssen CJ. “What happens when treatment fails? Developing better practice models for HCV patients post treatment.” Australasian Viral Hepatitis Conference, Melbourne Sept 2010

Dowdell LA. “Are We Ensuring Best Practice? Hepatocellular Carcinoma Audit?” Australasian Viral Hepatitis Conference, Melbourne, Sept 2010.

Janssen C. “Partnerships in Practice: Bridging the Gap Between Targeted CALD Communities and Health Services” Research to Practice Forum, Sydney, Aug 2011

Aggarwal V, Craig PI. “Can a prototype contrast capsule enhance capsule endoscopy image quality: a pilot study”. AGW Gold Coast, Oct 2010 (J Gastroenterol Hepatol 2010)

Aggarwal V, Craig PI. “Balloon-assisted direct peroral cholangioscopy using an ultraslim gastroscope”. AGW Gold Coast, Oct 2010 (J Gastroenterol Hepatol 2010)

Aggarwal V, Day AS, Connor S, Leach ST, Grimm M, Craig PI. “Correlation between capsule endoscopy ﬁndings and Crohn’s disease activity index, faecal calprotectin and S100A12 in small bowel Crohn’s disease patients in clinical remission”. AGW Gold Coast, Oct 2010 (J Gastroenterol Hepatol 2010)

44 Craig PI. “Direct Balloon-Assisted Cholangioscopy”. Australian & New Zealand Endoscopy Leaders Forum ,Noosa, Aug 2010.

Craig PI. “Novel management of gastro-cutaneous ﬁstulae with Surgisis plugs”. Australian & New Zealand Endoscopy Leaders Forum Noosa, Aug2010 and Australian Gastroenterology Week, Gold Coast, Oct 2010.

Cheluvappa R, Luo AS, Grimm MC. “Speciﬁc protective pathways induced by previous appendicitis and appendectomy ameliorates colitis”. Australian Gastroenterology Week, Gold Coast, Oct 2010.

Wong SM, Day AS, Lemberg D, Riordan S, Grimm MC, Budiman V, Mitchell H, Ismail Y, Zhang L. “Antibiotic susceptibility of campylobacter concisus isolated from patients with inﬂammatory bowel diseases”. Australian Gastroenterology Week, Oct 2010.

Luo AS, Grimm MC. “Altering the balance between regulatory and effector t cells in the colon: appendicitis is regulatory friendly”. Australian Gastroenterology Week Oct 2010.

Grimm MC. “Gastroenterology training in Australia: 2010 and beyond”. Queensland Gastroenterology Society, Royal Brisbane Hospital April 2010

Grimm MC. “Ethics approval: trial or opportunity?” AusMedTech: Running Clinical Trials in Australia, Sydney Nov 2010

Grimm MC, Metcalfe A, Wright M, D’Sousa A. “The HoMER accreditation process”. Australasian Ethics Network Conference 2010, Melbourne, Nov 2010

Cheluvappa R, Luo AS, Grimm MC. “Modulation of autophagy genes by appendicitis and appendectomy may protect against colitis”. Australian Gastroenterology Week, Brisbane, Sept 2011

Cheluvappa R, Luo AS, Grimm MC. “Th17 pathway suppression by appendicitis and appendectomy protects against colitis”. Australian Gastroenterology Week, Brisbane, Sept 2011

Grimm MC. “Appendicitis is not effective treatment for ulcerative colitis”. Australian Gastroenterology Week, Brisbane, Sept 2011

Grimm MC. “Inﬂammatory bowel disease and the skin. Raising Expectations in Dermatology.” Sydney, March 2011

Grimm MC. “Identifying the high risk IBD patient. Raising Expectations in Gastroenterology”. Sydney, June 2011

Grimm MC. “IBD: historical perspective and future promise”. AC Clarke Festschrift, Canberra, Sept 2011

Grimm MC. “IBD: essential knowledge for early trainees”. Australian Gut School, Brisbane, Nov 2011

45 Grimm MC. “The Gastroenterological Society of Australia – history of GE training in Australia”. Australian Gut School, Brisbane, Nov 2011

Grimm MC. “The Conjoint Committee: a world ﬁrst in recognition of endoscopy training”. Australian Gut School, Brisbane, Nov 2011.

COMMUNITY ENGAGEMENT

Dinning PG and Arkwright JW. Australian Museum Eureka Prize (2011) for Novel Application of New Technology.

Zekry A. Enhancing knowledge on viral hepatitis among General Practitioners working in CALD populations. Zekry A. Polis, S. in association with the multicultural division at RPAH and ASHM.

Zekry A. Executive member of the Australian Liver Association

Zekry A. NSW Ministerial advisory Committee for viral hepatitis

Zekry A. Chairperson for SESIAHS hepatitis C virus advisory group

Polis, S. NSW Health Dept AIDS/Infectious Disease Branch Hepatitis C MDS Steering Committee

Polis, S. TRAIDS Transitional Advisory Group

Polis, S. Gastroenterology Network Agency for Clinical Innovation (ACI). Hepatitis C Working Group

Polis, S. Sydney Liver Nurses Steering Committee

Polis S. Australasian Hepatology Associate Educational Sub committee

Polis S. ASHM Hepatitis B Virus education committee for registered nurses

Janssen C. SWAHS Multicultural Health Project Committee

Janssen C. TRAIDS Advisory Group

Janssen C . Bridging the Gap. Improving the links between CALD communities and health services. Information sessions for Arabic and Chinese community groups based on the concept of “Healthy Liver – Longer Life”

Janssen C. Steering Committee, Egyptian Hep C Project, Sydney West Area Health Service

Janssen C. Steering Committee, HepLink, Hepatitis NSW

46 Dowdell L. Australasian Hepatology Association Website Development Subcommittee

Cook IJ. Gastroenterology Executive Committee, NSW Agency for Clinical Innovation (ACI)

47 DEPARTMENT OF INFECTIOUS DISEASES, IMMUNOLOGY AND SEXUAL HEALTH

DEPARTMENTAL STAFF

Head of Department Prof. Steven A. Krilis, MB BS PhD FRACP FAAAAI DSC honoris causa (Athens) (Conjoint Professor of Medicine UNSW)

Senior Consultant Staff Dr. Pamela Konecny, (Director of Sexual Health) MB BS MD DTM&H(Lon) FRACP FAChSHM (Conjoint Snr Lecturer in Medicine UNSW) Dr. Chris Weatherall, MB BS FRACP (Conjoint Snr Lecturer in Medicine UNSW) Dr. Josephine Lusk, BSc MBChB FRNZCGP DRCOG FAChSHM MPH Dip MGT (Conjoint Senior Lecturer Medicine, UNSW) Dr Katerina Lagios, MBBS, MM (Sex Health) FAChSHM (VMO ) Dr. Judith Gardiner, MB BS DipPH, DipM [Sydney] FAChSHM (CMO)

Junior Medical Staff Dr. Indunil Sandaradura MBBS Advanced Trainee Infectious Disease (2010) Dr. Niladri Ghosh MBBS Advanced trainee Infectious Disease (2010) Dr. Christopher Heather MBBS Advanced trainee Infectious Disease (2011) Dr. Rohan Bopage MBBS Advanced trainee Infectious Disease (2011) Dr. Ruby Uddin, MBChB. Sexual Health Registrar (2010) RMO – As per rotation

Nursing and Allied Health Staff Suzy Wilds (NUM) Arlie Rochford (CNC) Jeanette Ball (CNS) Wendy Jarrett (CNS) Sharon Robinson (RN) Robyn Dever (RN) Marty Janssen (Senior Counselor) Melissa Cain (Senior Counselor) John Coady (Counselor)

Research Staff Dr. Jian Chen Qi Master of Medicine, Tianjin Medical University, China, PhD Garvan Institute, Senior Scientist./Laboratory Manager Dr. Gao Lu, Bachelor of Clinical Medicine, Tianjin Medical University, China, PhD Visiting Research Fellow Dr. Peng Zhang Dr Bill Giannakopoulos, MBBS, PhD, FRACP (Director of Research 2011)

48 Research Assistants Dr. Kumiko Tanaka, MSc, PhD, Miao Qi, Bachelor of Medicine in Medical Laboratory Science, Tianjin Medical University, China, MSc.

UNSW Yr4 ILP Medical Student Mayuri Sivagnanam

Clinical Trial Co-ordinator Robyn Dever CNS 2010

Research Student Peyman Mirarabshahi, PhD Student (UNSW) Mahmoud Abdelatti MSc Student (UNSW) Dr Josephine Lusk, part time PhD Student, University of Sydney. The Cervicitis Study.

RESEARCH GRANTS#

Category 1

National, peer reviewed:

2008-2010 - Pathophysiological Mechanisms in the Antiphospholipid Syndrome. NH&MRC -$510,000 2010-2013 - Delineation of the Role of RasGRP4 in mast cell growth differentiation and activation, using RasGRP4 deﬁcient mice. NHMRC - $613,500 2011-2014 - Tests for risk of thrombosis in patients with certain autoimmune conditions. NHMRC - $587,350.00 Total NHMRC = $1,710,850

Category 2

Other funding*:

University of New South Wales Goldstar Award $40,000 The role of mast cell specific serine proteases in inflammatory bowel disease in mice and humans - Steven Krilis. University of New South Wales Goldstar Award $40,000 The role of mast cell specific serine proteases in inflammatory bowel disease in mice and humans- Steven Krilis. 2011 - $550 - Red Ribbon grant from World Aids Day Committee- to Women and Childrens Health in collaboration with DIDISH. The grant subsidised an education event at St George Hospital- on 23/11/11 with 80 staff from nursing and allied health attended on HIV: a positive life in the suburbs. This focused on HIV with the heterosexual population group and pregnancy. Dr. J. Wong, UNSW Cancer Research Centre, University of New South Wales, Sydney.

49 RESEARCH PROJECTS IN PROGRESS

Steven Krilis: Pathophysiological Mechanisms in the Antiphospholipid Syndrome. The role of oxidative post-translational modiﬁcations of B2GPI in thrombosis and autoimmune disease.

Mass spectrometry of oxidatively post-translationally modiﬁed forms of β2GPI, Professor P. Hogg and Dr. J. Wong, UNSW Cancer Research Centre, University of New South Wales, Sydney.

The role of mMCP-6 in inﬂammatory bowel disease. Professor Michael Grimm, Department of Gastroenterology St. George Hospital, Professor R L Stevens, Department of Immunology, Rheumatology Harvard Medical School Boston, Mass.

Studies on FXI/FXIa binding to β2GPI using FXI mutants. Professor D. Gailani, Vanderbilt University, Nashville, Tennessee, USA

Molecular studies on RasGRP4 a speciﬁc mast cell GEF. Professor R L Stevens, Department of Immunology, Rheumatology Harvard Medical School Boston, Mass.

Crystallization studies of β2GPI. Investigator: Prof Michael W. Parker, Deputy Director and ARC Federation Fellow, Biota Structural Biology Laboratory, ACRF Rational Drug Discovery Facility, Centre for Structural Neurobiology, St. Vincent’s Institute of Medical Research, Melbourne, VIC.

Collaborating on the study analysing the role of beta 2-glycoprotein I in autoimmunity. Professor K Matthaei: Professor and Head Of The Gene Targetting Group at The John Curtin School of Medical Research.

Collaborating on the study analysing the role of beta 2-glycoprotein I in autoimmunity. Dr D Spielman: Senior veterinary scientist at the Sydney University School of Veterinary Medicine.

Collaborating on analysing the role of B2GPI on the immune response in autoimmune BXSB mice. Dr Robert Brink, Director of the Immunology Research Programme at the Garvan Institute.

Collaborating on a project the lipid metabolism aspect on the study analysing the role of beta 2-glycoprotein I in autoimmunity. Prof Kerri-Ann Rye and Dr Ben Wu from the Heart Research Institute Camperdown

Collaborating on a prospective international multicentre study examining the predictive and diagnostic role of novel ELISAs detecting oxidative post-translational modiﬁcations of B2GPI. Senior epidemiologist, Professor Tatsu Atsumi, Department of Medicine University of Sapporo, Hokkaido, Japan. A/Professor D. Erkan, Division of Rheumatology, Hospital for Special Surgery, New York, USA. Professor Takao Koike Head, Department of Medicine, University of Sapporo, Hokkaido, Japan. Professor Michael Lockshin, Head of Medicine at the Hospital for Special Children, New York USA and Director of Rheumatic Diseases and Lupus Research. Professor Harry Moutsopoulos, Director of Department of Medicine, University of Athens, Greece. Professor Michelle Petri, Professor of Medicine,

50 Division of Rheumatology, John Hopkins University School of Medicine, Baltimore, USA. Associate Professor P. Vlachoyiannopoulos, Department of Medicine, University of Athens, Greece. Associate Professor Stephane Heritier at the George Institute for International Health, University of Sydney.

Dr. Pam Konecny & Dr. Josephine Lusk: The Cervicitis Study: Aetiology of cervicitis in an STI clinic population in Sydney. A multi site cross sectional study of 541 women attending STI clinics in Sydney. This study is a collaboration with Professor William Rawlinson’s Virology research laboratory, SEALS, Randwick.

Increasing heterosexual gonorrhoea prevalence in an urban sexual health clinic: a retrospective case review 2008-2011. This study records a signiﬁcant change in the local epidemiology of gonorrhoea infection in the St George/ Sutherland STI clinic catchments.

Short Street Centre is a contributing site for the Australian Collaboration for Chlamydia Enhanced Sentinel Surveillance (ACCESS) Project

Gynaecological and female reproductive health outcomes in women with and without cervicitis in a Sydney STI clinic population – UNSW ILP project

The impact of tenofovir on renal function in an HIV cohort: retrospective case-controlled study of HIV patients attending Waratah HIV clinic 2000-1010

Role of Vitamin D deﬁciency and osteopaenia in HIV

Dr Pam Konecny: Quality and safety of antimicrobial prescribing at St George Hospital. Interhospital Departmental audits, review and feedback regarding best practice for antimicrobial prescribing.

Clinical Trials Robyn Dever CNS, Clinical Trials Co-ordinator Dr Pam Konecny, Principal Investigator

EVG A Multicenter, Randomized, Double-Blind, Double-Dummy, Phase 3 Study of the Safety and Efﬁcacy of Ritonavir-Boosted Elvitegravir (EVG/r) Versus Raltegravir (RAL) Each Administered With a Background Regimen in HIV1 Infected, Antiretroviral Treatment-Experienced Adults - Protocol GS- US-183-0145, dated 29 April 2008 (HREC Ref No: 08/SVH/124)

Flu An International Observational Study To Characterize Adults Who Are Hospitalized With Complications Of Inﬂuenza A – Pandemic H1N1 (H1N1v); INSIGHT H1N1v Hospitalization Study (FLU003) (HREC Ref No: 09/SVH/138)

Altair A randomised open-label study comparing the safety and efﬁcacy of three different combination antiretroviral regimens as initial therapy for HIV infection (ALTAIR) (07/14 Dr. P. Konecny)

51 ORIGINAL PEER-REVIEWED PUBLICATIONS

Redox control of β2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1.Passam FH, Rahgozar S, Qi M, Raftery MJ, Wong JW, Tanaka K, Ioannou Y, Zhang JY, Gemmell R, Qi JC, Giannakopoulos B, Hughes WE, Hogg PJ, Krilis SA. J Thromb Haemost. 2010 Aug;8(8):1754-62

Beta 2 glycoprotein I is a substrate of thiol oxidoreductases. Passam FH, Rahgozar S, Qi M, Raftery MJ, Wong JW, Tanaka K, Ioannou Y, Zhang JY, Gemmell R, Qi JC, Giannakopoulos B, Hughes WE, Hogg PJ, Krilis SA. Blood. 2010 Sep 16;116(11):1995-7.

In vivo modulation of angiogenesis by beta 2 glycoprotein I. Passam FH, Qi JC, Tanaka K, Matthaei KI, Krilis SA. J Autoimmun. 2010 Nov;35(3):232-40.

Naturally occurring free thiols within beta 2-glycoprotein I in vivo: nitrosylation, redox modiﬁcation by endothelial cells, and regulation of oxidative stress-induced cell injury. Ioannou Y, Zhang JY, Passam FH, Rahgozar S, Qi JC, Giannakopoulos B, Qi M, Yu P, Yu DM, Hogg PJ, Krilis SA. Blood. 2010 Sep 16;116(11):1961-70.

Yong AS, Pennings GJ, Chang M, Hamzah A, Chung T, Qi M, Brieger D, Behnia M, Krilis SA, Ng MK, Lowe HC, Kritharides L. Intracoronary shear-related upregulation of platelet P-selectin and platelet- monocyte aggregation despite the use of aspirin and clopidogrel. Blood. 2011;117(1):11-20.

Giannakopoulos B, Mirarabshahi P, Krilis S. New Insights into the biology and pathobiology of Beta 2-glycoprotein I. Curr Rheumatol Rep. 2011;13(1):90-5.

Hamilton MJ, Sinnamon MJ, Lyng GD, Glickman JN, Wang X, Xing W, Krilis SA, Blumberg RS, Adachi R, Lee DM, Stevens RL. Essential role for mast cell tryptase in acute experimental colitis. Proc Natl Acad Sci USA. 2011;108(1):290-5.

Ruiz-Irastorza G, Cuadrado MJ, Ruiz-Arruza I, Brey R, Crowther M, Derksen R, Erkan D, Krilis S, Machin S, Pengo V, Pierangeli S, Tektonidou M, Khamashta M. Evidence-based recommendations for the prevention and long-term management of thrombosis in antiphospholipid antibody-positive patients: report of a task force at the 13th International Congress on antiphospholipid antibodies. Lupus. 2011;20(2):206-18.

Novel assays of thrombogenic pathogenicity for the antiphospholipid syndrome based on the detection of molecular oxidative modiﬁcation of the major autoantigen ß2-glycoprotein I. Ioannou Y, Zhang JY, Qi M, Gao L, Qi JC, Yu DM, Lau H, Sturgess AD, Vlachoyiannopoulos PG, Moutsopoulos HM, Rahman A, Pericleous C, Atsumi T, Koike T, Heritier S, Giannakopoulos B, Krilis SA. Arthritis Rheum. 2011 May 26. doi: 10.1002/art.30383. [Epub ahead of print]

Molecular antiphospholipid syndrome: the role of oxidativepathophysiology of the post- translational modiﬁcation of beta 2 glycoprotein I. Passam FH, Giannakopoulos B, Mirarabshahi P, Krilis SA. J Thromb Haemost. 2011;1:275-82.

52 Risk stratiﬁcation and outcome of cellulitis admitted to hospital. Figtree M, Konecny P, Jennings Z, Goh C, Krilis SA, Miyakis S. J Infect. 2010 Jun;60(6):431-9.

Q fever cholecystitis in an unvaccinated butcher diagnosed by gallbladder polymerase chain reaction. Figtree M, Miyakis S, Stenos J, Graves S, Botham S, Ferson M, Krilis S. Vector Borne Zoonotic Dis. 2010 May;10(4):421-3

Trichomonas vaginalis: under-diagnosis in urban Australia could facilitate re-emergence. Sexually Transmitted Infections 2010;86 (3). MJ Lusk, Z Naing, N Rismanto, B Rayner, K.McGeechan, CJ McIver, WD Rawlinson and P Konecny.

Mycoplasma genitalium is associated with cervicitis and HIV in an urban Australian STI clinic population. MJ Lusk, P Konecny, ZW Naing,FL Garden, RG Cumming, WD Rawlinson. Online Sexually Transmitted Infections, Dec 2010

OTHER PUBLISHED MATERIAL (Books, Book Chapters, Reviews) (Not To Include Conf Abstracts)

Ioannou Y., Krilis S.A. “Laboratory testing in APLS”. Systemic Lupus Erythematosus, Fifth Edition: Edited by Robert Lahita. 2010; Ch52:985-995

The Youth Worker’s role in young people’s sexual health: A Practice Framework. In Youth Studies Australia Journal 2010. Marty Janssen and Jackie Davis

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

Krilis S. 22-24.1.10 Invited Plenary Speaker. Winter Scientiﬁc Rheumatology Meeting of Northwest Greece. Metsovo, Greece.

Krilis S. 13-16.4.2010 Invited Speaker and Member of Organising Committee. (a) Summary talk on Etiopathogenesis of APS. (b) “A new mechanism in the pathogenesis of the antiphospholipid syndrome: Implications for thrombotic risk stratiﬁcation.” (c) Meet the Professor - Diagnosis of APS. 13th International Congress on Antiphospholipid Antibodies. Galveston, USA.

Krilis S. 13-16.10.2010 Invited Speaker. 6th Congress of the Asia Paciﬁc Society on Thrombosis and Haemostasis. New Concepts of APS Diagnosis. Bali, Indonesia.

Krilis S. 2-4.11.2010 Invited Speaker. APS Clinical Research Task Force. Miami, Florida USA.

53 Krilis S. 6-11.11.10 ACR/ARHP Scientiﬁc Meeting. Invited Speaker, Antiphospholipid Study Group Meeting. 74th National Meeting, Atlanta, Georgia, USA.

Krilis S. 16-18.2.11. Invited Speaker. Excellence in Rheumatology. Istanbul, Turkey.

Krilis S. 26.2.11. Keynote Speaker. Sapporo International Rheumatology and Autoimmunity Symposium.

Krilis S. 20.4.11-30.4.11. Invited Speaker. Annual meeting of Immunologist - World Day for Immunology, Faculty of Medicine, Isfahan University, Isfahan, Islamic Republic of Iran.

Krilis S. 28.4.11. Plenary Speaker. Faculty of Medicine Isfahan University Symposium. Isfahan, Islamic Republic of Iran.

Krilis S. 28.6-4.7.11. Keynote Speaker. Autoimmune Diseases. Athens Greece. Awarded DSc honoris causa Athens University, Athens Greece.

Krilis S. Keynote Speaker. Cytopenia and Hemostasis. Chicago, USA.

Krilis S. 16.6.11. Session Chair. 60th Anniversary of the Medical University of Tianjin, Tianjin, China.

Krilis S. Invited Speaker. EULAR. London, UK.

Krilis S. 23-29.7.11. Invited Speaker. XIII Congress of the International Society of Thrombosis and Haemostasis. Kyoto, Japan.

Krilis S. 23-29.7.11. Session Chair. XIII Congress of the International Society of Thrombosis and Haemostasis. Kyoto, Japan.

Krilis S. Invited Speaker. Excellence in Rheumatology. Madrid, Spain.

Krilis S. 12-14.10.11. Invited Speaker. V Breton Workshop on Autoimmunity. Brest, France.

National

Steven Krilis. 9.6.10 Invited speaker. Diagnostic Immunology Discussion Group (DIDG), International Antiphospholipid Meeting, Melbourne, Vic.

Steven Krilis. 2011. Invited Speaker. 41st Australasian Society for Immunology, Annual Meeting. Adelaide, SA.

Konecny P. Australasian Society for HIV Medicine (ASHM) S100 Prescribers Course Cairns, QLD Dec 2010 Invited Speaker: HIV, Vitamin D and bone disease

Konecny P. Australasian Society for HIV Medicine (ASHM) HIV Education Course: Brisbane, QLD Jun 2010 Invited speaker: HIV, Vitamin D and bone disease

54 Konecny P. Australasian Society for Infectious Diseases (ASID) Annual Scientiﬁc Meeting May 2010: Invited speaker - HIV and bone disease

COMMUNITY ENGAGEMENT

Invited Panel Members of “Chinwag Chat show ” for people living with HIV/AIDS and their partners and carers, NAPWA, Brighton-le-Sands 2010 – Dr Pam Konecny, Mr John Coady

Priority Population Interagency meetings engaging with Community Leaders in St George/ Sutherland – Multicultural, Youth and Aboriginal

Liaison with and education workshops for GPs in St George and Sutherland Divisions in Sexual Health and HIV quarterly

Department has membership in SESIAHS HIV/AIDS and Related Programs (HARP) Clinical Services Committee, Performance and Planning Steering Committees and Minimum Data Set Informatics Committee

Membership SESIAHS Antimicrobial Stewardship Working Group – Dr Pam Konecny

Family Planning NSW, Clinical Advisory Board Member – Dr Pam Konecny

Steering Committee member: Healthy Communities Project: ‘Promoting Health & Wellbeing in our Newly Arrived Students 2010’- funded by Cultural diversity- Suzy Wilds NUM

Steering Committee member for ‘The UpZone’ (The UZ) a drop in youth health centre for young people under 25 yrs- Suzy Wilds NUM

Sexual Health outreach clinic for youth held at The UpZone (The UZ) on a weekly basis- Suzy Wilds NUM

Attendance and participation at Youth TAFE Health Expos St George, Gymea and Loftus- Suzy Wilds NUM

Monthly Sex worker outreach in St George and Sutherland areas, in conjunction with Sex Worker Outreach Programme (SWOP). Emphasis on CALD and other priority populations. Jeanette Ball (CNS) and Wendy Jarrett (CNS)

NSW SHOWnet (Sexual Health Outreach Worker’s network) bimonthly meetings. Interagency with HIV (AIDS) and Sexual Health , government and community based agencies. (Jeanette Ball, (CNS) and Wendy Jarrett (CNS)

IDU CHN ( Injecting drug users, Central Health Network) working group . Marty Janssen (Senior Counsellor) and Wendy Jarrett and Melissa Cain (Senior Counsellor) Participation in sexual health information provision SEXPO 2010 in partnership with HARP

55 Shirewide youth interagency meetings – Wendy Jarrett

Education and liaison with Kirinari Aboriginal Youth Centre, Sutherland Shire. (Wendy Jarrett, CNS)

“Caddyshack” Marty Janssen (Senior Counsellor) Caddyshack is a youth-focused mobile Chlamydia screening project that visits youth and community events promoting sexual health awareness, and offering on-site Chlamydia screening. It is a partnership project involving Short St sexual health service, the HIV/AIDS and Related Programs (HARP) Unit SESLHD and Shirewide Youth Service.

56 DEPARTMENT OF INTENSIVE CARE /ST GEORGE CLINICAL SKILLS CENTRE

DEPARTMENTAL STAFF*

Head of Department A/Prof Theresa Jacques MBBS (Hons) FANZCA FCICM MHL Director Department of Intensive Care St George Hospital, 2010/11 Conjoint Associate Professor University of New South Wales Chief Editor DETECT

Senior Medical Staff Professor John Myburgh MBBCh PhD FCICM (Head of Research), 2010/11 Senior Staff Specialist Director, Critical Care & Trauma Division, The George Institute for Global Health Professor of Critical Care Medicine, University of New South Wales President, College of Intensive Care Medicine

Dr Manoj Saxena M.R.C.P, FRACP, F.J.F.I.C.M, F.C.I.C.M, M.B. B. Chir, Bsc (Hons) 2:1 Immunology, 2010/11 Staff Specialist Conjoint Lecturer, St George Clinical School, UNSW Honorary Fellow, Critical Care & Trauma Division, The George Institute for Global Health

A/Professor George Skowronski MMBS (Hons), FRCP,FRACP,FCICM, 2010/11 Senior Staff Specialist Conjoint Associate Professor, Critical Care, UNSW

A/ Prof Konstantin Yastrebrov MBBS (Hons) PHd FCICM FACRRM DDU, 2011 Conjoint Associate Professor University of NSW, Senior Honorary Fellow, The University of Melbourne. Member of Steering Committee for Postgraduate Diploma of Echocardiography.

Dr Andrew Cheng BHB, MBChB(NZ), FCICM, 2010/11 Staff Specialist Hospital Medical Director – Organ and Tissue Conjoint Lecturer, St George Clinical School, UNSW

Dr Kush Deshpande MBBS, MD, FCICM, 2010/11 Staff Specialist Conjoint Lecturer, St George Clinical School, UNSW

57 Dr Doris Lam FCICM, FANZCA, MBChB, 2010/11 Senior Staff Specialist, ICU Conjoint Lecturer, St George Clinical School, UNSW

Visiting Medical Ofﬁcers Dr Nhi Nguyen B. Med. Sci FCICM, 2010/11 Conjoint Lecturer, Medical School, University of Sydney Dr Monique Leijten, 2011 Dr Marek Nalos, 2011 Dr Mathew Macpartlin, 2011 Dr Razavian Maziar, 2011 Dr Barbara Trytko, 2011

Senior Registrars Dr.Ajit Sivankaran 2011 Dr.Tejo Kapalli 2011 Dr.Tusher Yadavmalli 2011 Dr.Mahadev Patil 2011 Dr Kiran Deol 2011 Dr Raju Pusapati 2011 Dr Atul Gaur 2010 Dr Nitan 2010 Dr Cartan Costello 2010/11 Dr Asako Ito 2010/11 Dr Paris Jain 2010 Dr Sharmilli Sinha 2010

Registrars Dr. Carmen Yip 2010/11 Dr. Martin Keady 2010/11 Dr. Ajay Kg 2010 Dr Raj Vaswani 2010/11 Dr Richard Accurso 2010/11 Dr Suyen Ho 2010 Dr Pham Ngoc Hanh 2010/11 Dr Andrew Arrowsmith 2010/11 Dr Robert Heavener 2011 Dr Mary Stevens 2011 Dr Jeanne Wu 2011 Dr Shawn Ng 2011 Dr Michael Kerr 2011 Dr Katrina Tsacalos 2011

58 Research Assistants Deborah Inskip, BSc, Clinical Nurse Specialist Quality, Education, Research and Information Ofﬁcer Research Coordinator

Rebecca Sidoli, Dip Apl Sc, ICU Cert, Clinical Nurse Specialist Quality, Education, Research and Information Ofﬁcer

Jennene Miller, BSc, Clinical Nurse Specialist Research Coordinator

Nursing & Allied Health Warren Eather, Clinical Data Manager

Kylie Fraser. BappSc OT Manager St George Clinical Skills Centre. Clinical Skills Centre Executive Member. Member Editorial Panel DETECT programme

RESEARCH GRANTS#

Category I - Nationally Competitive Grants:

The Crystalloid vs Hydroxyethyl starch Trial. (CHEST) National Health and Medical Research Council. Project Grant: 632503 Myburgh J.A., Finfer S.R, Bellomo R, Lipman J, Webb S.R, Liu B. 2010-2014: $2.1M

National Centre for Intensive Care research. National Health and Medical Research Council. Enabling grant extension: 606978 Bellomo R, Myburgh JA Finfer SR, Cooper DJ 2010-2015: $2.5M

Intensive insulin therapy trialists collaboration. National Health and Medical Research Council. Project Grant: 632809 Finfer S.R., Myburgh J.A., VD Berghe G, Cook D.J., Liu B. 2010: $375 000

Extended Follow-up of the RENAL Study Cohort and Individual Patient Data Meta-analysis of Dialysis in Severe Acute Kidney Injury National Health and Medical Research Council. Project Grant: 632811 Gallagher M., Cass A., Bellomo R., Turnbull F., Finfer S.R., Myburgh J.A., Kellum J, Palevsky P. 2010: $685 000

59 A randomised controlled trial of the effects of hydrocortisone on mortality in critically ill patients with septic shock. National Health and Medical Research Council: Project Grant 1004108 Venkatesh B, Myburgh J.A., Finfer S., Webb S, Cohen J 2011: $3.2M

Category II - Other competitive grants:

The efﬁcacy, cost-effectiveness and environmental impact of selective decontamination of the digestive tract in critically ill patients treated in the Intensive Care Unit. Intensive Care Foundation: Project Grant Seppelt I, Myburgh J.A, Finfer S.R, Lipman J ,Paterson D, Cuthbertson B, Francis J, Glass P 2010: $40 000

The cost of major trauma in New South Wales: linkage, analysis and recommendations for health services planning St George Medical Research Foundation: Establishment Grant Curtis K, Myburgh J.A., Black D, Langcake 2010: $10 000

Pilot RCT of continuous beta-lactam infusion compared with intermittent dosing in critically ill patients. Intensive Care Foundation : Project Grant: Lipman J, Webb S, Dulhunty J, Myburgh J.A., Bellomo R, Paterson D, Roberts J 2010: $20 000

A phase IIB study of Intravenous Paracetamol in Reducing Core Temperature after Traumatic Brain Injury. Australian and New Zealand College of Anaesthetists Project Grant: 09/008 Saxena M.K, Myburgh J.A., Gowardman J., Lipman J 2009-2013, $30,000

A Prospective Cohort Study of Temperature Management after Traumatic Brain Injury in Australia and New Zealand. St George Medical Research Foundation: Establishment Grant Saxena M.K., Myburgh J.A., Seppelt I. 2009-2011: $20,000

Permissive HyperthErmiA Through Avoidance of Paracetamol in Known or Suspected Infection in ICU The New Zealand Health: Research Council Young P Beasley R, Saxena M, McArthur C, Henderson S, McGuinness S, Freebairn R, Haren F, Myburgh J.A, Bellomo R, Webb S, Andrews L, Mackle D 2011-2013, $1,200,000

60 Category III – Industry and other research funding:

New strategies for resuscitation of patients with severe sepsis Danish Council for Strategic Research: Project Grant. Perners A, Myburgh J.A. (co-applicant) 2010: $200 000

Australian and New Zealand sedation practices in intensive care (SPICE) Hospira to Prince of Wales Hospital Research Trust Shehabi Y, Bellomo R, Myburgh J.A, Reade M, Seppelt I, Webb S 2011, US 200 000

The Honda Foundation Trauma and Critical Care Research Program Honda Corporation to St George Medical Research Foundation Myburgh J.A, Langcake M, Curtis K, Saxena M 2011-2013: $150 000

RESEARCH PROJECTS IN PROGRESS

Topic: Improving patient safety through blended learning: training instructors for the DETECT programme. Principal investigators: T. Jacques. K Fraser

Topic: The Early Parental Nutrition Study. Principal investigator: T. Jacques

Topic: Crystalloid versus Hydyroxyethyl Starch Trial (CHEST) Principal investigator: J. Myburgh, M Saxena

Topic: PARITY Study Principal investigator: M. Saxena

Topic: Post Renal Principal investigator: J. Myburgh

Topic: SPICE Principal investigator: J. Myburgh

Topic: PREDICT Study Principal investigators Dr. Jorge Brieva (John Hunter), Dr. Andrew Cheng (St George)

Topic: Bacteremia in Intensive Care Unit – Temporal Trends in Epidemiology and Antimicrobial Susceptibility Principal investigator: Asako Ito, Warren Ether, Doris Lam, Kush Deshpande

61 Topic: A point prevalence study of temperature management after traumatic brain injury in Australia and New Zealand Principal investigator: Saxena M, Taylor C, Glass P, Myburgh J, Seppelt I, Young P

Topic: A retrospective multi-centre study of temperature management after traumatic brain injury. Principal investigator: Saxena M, Taylor C, Glass P, Myburgh J, Hammond M

Topic: A cross-sectional study of temperature management after traumatic brain injury. Principal investigator: Saxena M, Taylor C, Glass P, Myburgh J, Seppelt I, Hammond N

Topic: Early peak temperature and mortality in critically ill patients with neurological injury Principal investigator: Young P, Saxena M, Beasley R, Bellomo R, Bailry M, Pilcher D, Finfer S, Harrison D, Myburgh J, Rowan K

Topic: The PARITY study: a phase 2b randomised, controlled clinical trial to assess the safety and efﬁcacy of intravenous paracetamol in reducing core body temperature after traumatic brain injury. Principal investigator: Saxena M, Taylor C, Myburgh J, Glass P, Gowardman J, Lipman J

Topic: A Survey of How Doctors Manage Fever After Traumatic Brain Injury: Do Doctors Use Non-Ster oidal Anti-Inﬂammatory Medicines? Principal investigator: Deol K, Hammond N, Saxena M, Myburgh JA

Topic: Comparison of core and peripheral temperature measurement in adult critically ill patients with brain injury. Principal investigator: Liu A, Hammond N, Saxena M, Myburgh J

Topic: Target Temperature Management after Cardiac Arrest Trial Principal investigator: Saxena M, Myburgh J

Topic: The Fever Epidemiology, Variability and Effects Re-evaluation (FEVER) study Principal investigator: Saxena M, Bellomo R, Young P, Santamaria J, Kruger P, Gattas D, Bailey M

Topic: A multi-centre prospective cohort study of fever and fever management in intensive care in patients with known or suspected infection Principal investigator: Young P, Saxena M, Eastwood G, Beasley R

Topic: A survey of fever management in febrile intensive care patients without neurological injury. Principal investigator: Saxena M, Hammond N, Taylor C, Young P, Reade M, Bellomo R, Myburgh J

Topic: A Point Prevalence Study of Fever Management in Patients with Sepsis and Inﬂammation Principal investigator: Hammond N, Saxena M, Taylor C, Young P, Seppelt I, Glass P, Myburgh J

Topic: Inﬂuenza Pandemic Protocol for ICU Triage Study Principal investigator: Cheung W, Saxena M, Myburgh J, Gandhi K, Parr M, Thanakrishnan G, Seppelt I

62 Topic: PROWESS Shock Principal investigator: Myburgh J, Saxena M, Jacques T

Topic: International Nutrition Survey Principal investigator: Saxena M, Dragievic H, Bell J

Topic: Sedation Practices in Intensive Care Evaluation Principal investigator: Myburgh, J, Cheng A

Topic: Prospective cohort study of Vitamin D in Critically Ill Patients Principal investigator: Saxena M

Topic: Nephro Protective Trial Principal investigator: T. Jacques

Topic: Comparison of Conventional versus protocol based management of Diabetic Ketoacidosis Principal investigator: N. Chavan, G. Bishop, K. Deshpande

Topic: Acute Kidney Injury in patients undergoing peritonectomy with intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC) Principal investigator: A. Gaur, K Deshpande, J. Myburgh

Topic: The Practice of Mechanical Ventilation in a tertiary Intensive Care Unit in Australia Principal Investigator: C. Costello, K. Yastrebov, K. Deshpande, Saxena M,

Topic: Bacteraemia in Intensive Care Unit - Temporal Trends in Epidemiology and Antimicrobial Susceptibility Principal Investigator: A. Ito, W. Eather, D. Lam, K. Deshpande

ORIGINAL PEER-REVIEWED PUBLICATIONS

Myburgh J.A. (2011). Fluid resuscitation – time to reappraise the basics. New England Journal of Medicine. (Editorial). 364: 2543-2544.

Principal author / member of writing committee: other publications

Taylor C., Fitzharris M., Liu B., Jan S., Middleton P., Stevenson M., Myburgh J.A. (2010). A systematic review of costs and beneﬁts of helicopter emergency medical services. Injury 41: 10-20.

Jones D., McEvoy S., Merz T., Higgins A., Bellomo R., Cooper D., Hollis S., McArthur C., Myburgh J.A., Taylor C., Liu B., Norton R., Finfer S. (2010). International albumin use: 1995 to 2006. Anaesthesia and Intensive Care 38: 266-273.

63 Jun M., Lambers Heerspink H.J., Ninomiya T., Gallagher M., Bellomo R., Myburgh J.A., Finfer S., Palevsky P., Perkovic V., Cass A. (2010) Effect of different intensities of renal replacement therapy in patients with acute kidney injury: a systematic review and meta-analysis of randomised controlled trials. Clinical Journal of the American Journal of Nephrology 5:956-963.

Dulhunty J., Webb S., Paterson D., Bellomo R., Myburgh J.A., Roberts J., Lipman J. (2010) A. survey of antibiotic prescribing practices in Australia and New Zealand Intensive Care Units. Critical Care and Resuscitation 12: 162-170.

Myburgh J.A. (2010). Norepinephrine – more of a neurohormone than a “vasopressor”. Critical Care 14: 196.

SAFE Study Investigators. (2010). (Myburgh J.A.: Member: Writing Committee). Impact of albumin compared to saline on organ function and mortality of patients with severe sepsis. Intensive Care Medicine 37:86-96.

Finfer S.R., Liu B., Taylor C., Bellomo R., Billot L., Cook D., Du B., McArthur C., Myburgh J.A., the SAFE TRIPS Investigators. (2010). Resuscitation ﬂuid use in critically ill patients – a cross national survey in 139 Intensive Care Units. Critical Care 14: R185.

The CHEST Management Committee. (2011) (Myburgh J.A. Chair: Writing Committee). The crystalloid versus hydroxyethyl starch trial (CHEST): protocol for a multicentre randomised-controlled trial of ﬂuid resuscitation with 6% hydroxyethyl starch (130/0.4) compared to 0.9% saline in intensive care patients on mortality. (2011). Intensive Care Medicine 36: 816-823

Taylor C., Stevenson M., Jan S., Liu B., Tall G., Sinclair G., Middleton P., Fitzharris M., Myburgh J.A. (2011). An investigation into the cost and function of helicopter emergency medical services in the state of New South Wales, Australia. Injury 42: 1088-1094.

Myburgh J.A. (2011). CHEST and impact of fraud in ﬂuid resuscitation research. Critical Care and Resuscitation (Editorial) 2: 69-70.

Myburgh J.A. (2011). Research fraud and ﬂuid resuscitation research. Medical Journal of Australia (Editorial). 194: 621-622.

Fitzharris M., Zhong W., Myburgh J.A., Xuezhong Y., Yu J., Hammond N., Finfer S., Taylor C., Wu Y. (2011). The status of trauma registry systems in Chinese hospitals. Injury Prevention 17: 419-421.

Fitzharris M., Yu J., Hammond N., Taylor C., Wu Y., Finfer S., Myburgh J.A. (2011). Injury in China: a systematic review of injury surveillance studies conducted in Chinese emergency departments. BMC Emergency Medicine 11: 1-18.

Saxena M, MK. Hammond, NE. Taylor, C. Young, P. Reade, M. Bellomo, R. Myburgh, J.A. (2011). A survey of fever management in febrile intensive care patients without neurological injury. Critical Care and Resuscitation 13: 238-242.

64 Young P, Saxena M, Eastwood G, Bellomo G, Beasley R. (2011) Fever and fever management among intensive care patients with known or suspected infection: a multicentre prospective cohort study. Crit Care Resusc 13(2):97-102:

Young P, Saxena M, Beasley R. Fever and antipyresis in infection. (2011) Med J Aust 195(8):458-9:

Collaborative publications: member of management/steering committee or principal investigator at participating site

Reade M.C., Delaney A., Bailey M.J., Harrison D.A., Rowan K.M., Bellomo R., Angus D.C., for the Australian Resuscitation in Sepsis Evaluation (ARISE), United Kingdom Protocolised Management In Sepsis (ProMISe), and United States Protocolized Care for Early Septic Shock (ProCESS) Investigators. (2010). (Myburgh J.A: Member Management Committee: ARISE Study). Prospective meta-analysis using individual patient data in critical care medicine. Intensive Care Medicine 36: 11-21.

INFACT Global Collaboration. (2010). (Myburgh J.A.: Member steering committee). INFACT: a global critical care research response to H1N1. Lancet: 375:11-13.

Robertson M., Nichol A., Higgins A., Bailey M., Presneill J., Cooper D.J., Webb S., MacArthur C., MacIsaac C and the VTE Point Prevalence Investigators for the ANZIC-RC and ANZICS CTG. (2010). (Myburgh J.A.: Principal Investigator: St George Hospital). Venous thromboembolism prophylaxis in the critically ill: a point prevalence survey of current practice in Australian and New Zealand Intensive Care Units. Critical Care and Resuscitation 12: 9-15

Blood observational study investigators of the ANZICS Clinical Trials Group. (2010). (Myburgh J.A.: Principal Investigator: St George Hospital). Transfusion practice and guidelines in Australian and New Zealand Intensive Care Units. Intensive Care Medicine 36:1138-1146.

CRASH-2 trial collaborators. (2010). Myburgh J.A.: Member Data Monitoring Committee). Effects of tranexamic acid on death, vascular occlusive events and blood transfusion in trauma patients with signiﬁcant haemorrhage (CRASH-2): a randomised-controlled trial. Lancet 376:23-32.

Nichol A., Bailey M., Cooper D.J and the POLAR and EPO Investigators. (2010). (Myburgh J.A.: Member: POLAR Management Committee). Challenging issues in randomised-controlled trials. Injury 41 (Suppl 1): S20-23.

Cuthbertson B., Francis J., Campbell M.K., Macintyre L., Seppelt I., Grimshaw J and the SuDDICU Study Group. (2010). (Myburgh J.A.: Member: Australia and New Zealand Study Group). A study of the perceived risks, beneﬁts and barriers to the use of SDD in adult critical care units (The SuDDICU study). Trials 11:117.

Davies A, Morrison S, Ridley E, Bailey M, Banks M., Cooper D., Hardy G., McIlroy K. Thomson A for the ASAP Study Investigators. (2011). Myburgh J.A: Principal Investigator: St George Hospital). Nutritional therapy in patients with acute pancreatitis requiring critical care unit management: a prospective observational study in Australia and New Zealand. Critical Care Medicine 39:426-468.

65 The CRASH-2 Collaborators, Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt B, Morales C, Perel P, Prieto-Merino D, Woolley T. (2011). Myburgh J.A.: Member Data Monitoring Committee). The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised-controlled trial. Lancet 377:1096-1101.

Pettila V., Westbrook A., Nichol A., Bailey M., Wood E., Syres G., Phillips L., Street A., French C., Murray L., Orford N., Santamaria J., Bellomo R., Cooper D for the Blood Observational Study Investigators of the Australian and New Zealand Intensive Care Society Clinical Trials Group. (2011). Myburgh J.A: Principal Investigator: St George Hospital). Age of red blood cells and mortality. Critical Care 15: R116.

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

Myburgh J.A. (2010). “I am sorry, but I have no idea who you are.” In: End of life in Intensive Care Unit – from advanced disease to bereavement. (Rocker G., Azoulay E., Puntillo K., Nelson J. eds). Oxford: Oxford University Press. pp 290-293

T. Jacques. M Fisher. K Hillman K.Fraser G Reece (Editors). DETECT (Detect deterioration, Evaluate, Escalate and Communicate with your Team) Manual 3rd Edition 2011

Chapters: A/Prof Theresa Jacques - DETECT Manual (3rd Edition) Chapter Author “When to Worry” and “Specialty Module: DETECT for Obstetrics” Dr Doris Lam – DETECT Manual Chapter Author (3rd Edition) “The Confused Patient” Dr Nhi Nguyen – DETECT Manual Chapter Author (3rd Edition) “The Five Causes of Anuria”, “Specialty Module: DETECT for Obstetrics” T. Jacques. M Fisher. K Hillman K.Fraser (Editors). DETECT (Detect deterioration, Evaluate, Escalate and Communicate with your Team) Manual 2nd Edition 2010. T. Jacques. M Fisher. K Hillman K.Fraser G Reece (Editors). DETECT Trainers’ Manual 2nd Edition 2010

A/Prof Theresa Jacques - DETECT Chapter Author (2nd Edition) “When to Worry” Dr Doris Lam – DETECT Chapter Author (2nd Edition) “The Confused Patient” Dr Nhi Nguyen – DETECT Chapter Author (2nd Edition) “The Five Causes of Anuria” A/Prof Richard Morris DETECT Chapter Author (2nd Edition) –“Airway Resuscitation”

Dr M Saxena - Early management of acute traumatic brain injury in Emergency and Trauma Care (Editors: Curtis and Ramsden), Published Elsevier Australia, 2011.

Dr M Saxena - New South Wales Agency for Clinical Innovation: Parenteral Nutrition Handbook. 2011

Reports: T Jacques (Member of executive committee ): “Conﬂict Resolution in End of Life Settings (CRELS) Final Report” NSW Health 2010 www.health.nsw.gov.au

66 PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

M Saxena Indian Society of Critical Care Medicine, Hyderabad, India February 2010 “Therapeutic thermal regulation for traumatic brain injury”

M Saxena 1st Prize for scientiﬁc abstract (October 2011, International Sepsis Forum, Beijing, China): Early peak temperature and mortality in critically ill patients with or without infection.

T. Jacques. K Fraser. G Reece Improving patient safety through blended learning: training instructors for the DETECT programme. The Scandinavian Society of Anaesthesiology and Intensive Care Medicine 31st Congress Gireghallen, Bergen, June 15-17, 2011

Yastrebov K; Jacques T; Pusapati R Logistics and Educational Aspects of the Introduction of Ultraportable Echocardiography (UPE) into a Medical Emergency System 24th ESICM Congress Berlin Germany October 2011

Cheng, A; Logistics and education aspects of the introduction of ultraportable echocardiography into a medical emergency system (MET), ESICM, Berlin, Germany, October 2011

Plenary lectures at international meetings

Myburgh J.A. January 2010. (St Andrews, Scotland). Evidence for the use of vasopressors in critically ill patients. Scottish Intensive Care Society Annual Scientiﬁc Meeting.

Myburgh J.A. January 2010. (St Andrews, Scotland). Development of a clinical algorithm for intracranial hypertension: the Brain Trauma Foundation consensus process. Scottish Intensive Care Society Annual Scientiﬁc Meeting.

Myburgh J.A. September 2010. (Paris). Fluid resuscitation in Australia and New Zealand: the CHEST Study. International Sepsis Forum. Sepsis 2010.

Myburgh J.A. September 2010. (Copenhagen). Individual patient-data meta-analysis in Intensive Care Medicine. Scandinavian Clinical Trial Group Annual Scientiﬁc Meeting.

Myburgh J.A. January 2011. (Lake Louise, Canada). Multicentred trial update from Australia and New Zealand: The CHEST and ESCAPE trials. Canadian Critical Care Trials Group Annual Scientiﬁc Meeting

Myburgh J.A. July 2011. (London). The CHEST trial – a deﬁnitive answer to the starch debate? World Congress in Evidence Based Perioperative Medicine with the Great World Fluid Debate.

Myburgh J.A. November 2011. (Auckland). Resuscitation ﬂuids in critical care. New Zealand Society of Anaesthetists Annual Scientiﬁc Meeting.

67 Myburgh J.A. November 2011. (Auckland). Reappraising the evidence for the use of vasoactive agents in critically ill patients. New Zealand Society of Anaesthetists Annual Scientiﬁc Meeting.

Myburgh J.A. November 2011. (Auckland). National Journal Club: Intensive Care Medicine 2011. New Zealand Society of Anaesthetist Annual Scientiﬁc Meeting.

National

Ms Julie Letts, A/Professor Theresa Jacques, A/Professor Cameron Stewart Medical futility, end of life conﬂict and the case of Isaac Messiha Australian Bioethics Health Law Conference June 2011 T. Jacques. K.Fraser. Intern perceptions of the impact of a pre-intern blended learning programme (DETECT) as preparation for intern year. Australian Society for Simulation in Healthcare (ASSH) 7th Annual Conference. Sydney. 12- 15 September 2011.

T. Jacques. K Fraser. G Reece Improving patient safety through blended learning: training instructors for the DETECT programme. St George and Sutherland Medical Research Symposium 20th October 2011.

T. Jacques. Education for rapid response systems: DETECT Australian College of Critical Care Nurses (ACCCN) / Australian and New Zealand Intensive Care Society (ANZICS) Conference. Burnie Tasmania. 13th August 2011

Cheng. A; Prolonged overexpansion of extracellular water in elderly patients with severe sepsis, CICM Annual Scientiﬁc Meeting, Brisbane, Australia June 2010

Myburgh J.A. June 2011. (Canberra). Sustainable Intensive Care. College of Intensive Care Medicine Annual Scientiﬁc Meeting.

Invited lectures at national meetings

Myburgh J.A. March 2010. (Noosa). The Crystalloid versus Hydroxyethyl starch Trial (CHEST). Australian and New Zealand Intensive Care Society Clinical Trials Group Annual Meeting.

Myburgh J.A. March 2010. (Noosa). SAFE TBI II – results. Australian and New Zealand Intensive Care Society Clinical Trials Group Annual Meeting.

Myburgh J.A. March 2010. (Melbourne). What ﬂuid should I use for resuscitation? World Congress of Internal Medicine

Myburgh J.A. October 2010. (Melbourne). CHEST update. Australian and New Zealand Intensive Care Society Clinical Trials Group Spring Research Forum.

Myburgh J.A. March 2011. (Noosa). CHEST update …….. and the Boldt controversy. Australian and New Zealand Intensive Care Society Clinical Trials Group Annual Scientiﬁc Meeting.

68 Myburgh J.A. March 2011. (Sydney). Is albumin bad for the brain? World Congress of Paediatric Critical Care Medicine.

Myburgh J.A. August 2011. (Hunter Valley). Beyond SAFE and CHEST: priorities for ﬂuid resuscitation research. Australian and New Zealand Intensive Care Society Clinical Trials Group Winter Research Forum.

Myburgh J.A. August 2011. (Burnie, Tasmania). Sustainable Intensive Care. Australian and New Zealand Intensive Care Society Regional Scientiﬁc Meeting.

Myburgh J.A. October 2011. (Brisbane). CHEST: the second interim analysis. Australian and New Zealand Intensive Care Society Clinical Trials Group Spring Research Forum

M Saxena June 2011: The 2nd Annual Scientiﬁc Meeting of the College of Intensive Care Medicine: Debate (pro) Consultants should work a shift system and retire early.

M Saxena November 2011: Mechanical Ventilation Panel: ACCCN/ICCMU Annual Meeting.

M Saxena November 2011: The Watson Memorial Lecture (St George and Sutherland Medical Research Symposium) “Hot bodies survive … Cool heads (may) help … The trickiness of temperature”

N. Chavan, K. Deshpande Poster presentation at CICM ASM 2011 Comparison of Conventional versus protocol based management of Diabetic Ketoacidosis

A. Gaur, K Deshpande, J. Myburgh Poster presentation at CICM ASM 2011 and St George Hospital Research Symposium 2011. Acute Kidney Injury in patients undergoing peritonectomy with intraoperative hyperthermic intraperitoneal chemotherapy (HIPEC)

COMMUNITY ENGAGEMENT

T Jacques, M Fisher K Fraser. Train- the trainer DETECT programmes for rural networks including rural general practitioners and nurse practitioners; Gosford April 2010, (TJ, KF, MF), John Hunter June 2010 (TJ, KF) Orange June 2010 (MF, TJ), Dubbo (TJ, MF), Broken Hill (TJ) (August 2010).

T Jacques, G Reece, K Fraser Statewide Super Trainer Program for DETECT conducted at Blacktown and St George Hospitals, sponsored by the CEC in 2010.

T Jacques K Fraser M Rowley: Pilot DETECT_ Maternity Programme for midwives and obstetricians John Hunter Hospital November 2011

T Jacques, K Fraser , W Eather, B Eather, M Fisher Train- the trainer DETECT programmes for rural networks including rural general practitioners and nurse practitioners; Grafton August 2011 (TJ,KF,WE,BE,MF), Mudgee November 2011(TJ,KF)

69 Cheng. A; “Organ Donation: A Gift of Life”: Presentation for the Gift of Life Foundation, December 2010

Cheng. A; “Organ and Tissue Donation: Health and Beneﬁts”: Presentation for the Pole Depot Chinese Community Project, Hurstville, October 2011

George Skowronski, Chairman, Australian Intensive Care Foundation, 2010

Professor John Myburgh President: College of Intensive Care Medicine St George Clinical School Research Excellence Award: for recognition of valuable contributions to research. (2010). Member Scientiﬁc Advisory Committee, St George Medical Research Foundation Board of Directors, Intensive Care Foundation. Member, Department of Health and Ageing: Medical Beneﬁts Scheme Quality Framework Clinical Working Group. Canberra 2010-2011

M Saxena Invited Speaker at The Lamrock Committee’s Annual High Tea Fundraiser for St. George Hospital (October 2011).

70 DEPARTMENT OF NUCLEAR MEDICINE

DEPARTMENTAL STAFF

Head of Department Dr Patrick Butler, MA, MD, MBA, FRACP

Senior Medical Staff Dr Scott Beuzeville, BMed(Hons), FRACP Dr Richard Quinn, MBBS, DDU, FRACP Dr Ramy Nour, MBBS, FRACP

Junior Medical Staff Dr Sobia Khan, MBBS Dr Rosamma Bency, MBBS

Physics Staff Senior research staff: Dr Richard Smart, PhD, MACPSEM, FARPS Dr Erin Mckay, PhD

Medical Radiation Scientists Mr Peter McConachie, BAppSci, MCom Mr Andrew Cluff, BAppSci, MBA

Radiochemist Ms Efﬁe Browne, BAppSci, MScMed

Research Assistant Ms Gabriel Botros, BSc

Conjoint Appointments Dr Patrick Butler holds a conjoint appointment as Associate Professor UNSW Dr Richard Smart holds a conjoint appointment as Associate Professor UNSW

71 RESEARCH GRANTS

None reported

Other funding Nuclear Medicine Research Fund

RESEARCH PROJECTS IN PROGRESS

Title Investigators

Comparison of Ga-68 Dotatate scanning and Lu-177 Dotatate scanning in NET Dr Patrick Butler patients undergoing Peptide Receptor Radionuclide Therapy.

Calculation of radiation dosimetry in Peptide Receptor Radionuclide Therapy Dr Erin McKay using Lu-177 Dotatate in NET patients.

Clinical efﬁcacy of Lu-177 Dotatate therapy in patients with progressive NET not Dr Patrick Butler. responsive to conventional therapies..

ORIGINAL PEER-REVIEWED PUBLICATIONS

2010

Smart RC. 2009 Australian Radionuclide Dose Calibrator Survey. ANZ Nuclear Medicine, 2010, 41 No 3, 2-5.

Botros GM, Towson JE, Smart RC. Updated paediatric diagnostic reference activities for nuclear medicine procedures in Australia and New Zealand derived from the 2009 survey. ANZ Nuclear Medicine, 2010, 41 No 4, 12-18

Schembri GP, Miller A, Smart RC. Radiation dosimetry and safety issues in the investigation of pulmonary embolism. Seminars in Nuclear Medicine, 2010, 40:442-454

72 2011

Brown MA, Pirabhahar S, Kelly JJ, Mangos GJ, Mackenzie C, McConachie P, Janssen J, Smart RC. Inaccuracies in estimated glomerular ﬁltration rate (eGFR) in one Australian renal centre. Nephrology, 2011, 16:486-494

Morris TA., Gerometta M, Smart RC, Eisenberg P, Roach PJ, Tsui WW, Better N, Taubman KL, Unger SA, Angelides S, Cehic G, Macfarlane D. Pulmonary emboli imaging with Tc-99m labeled anti-D-dimer (DI-80B3) Fab’ followed by SPECT. Heart, Lung and Circulation, 2011, 20:503-511

Morris TA, Gerometta M, Yusen RD, White RH, Douketis JD, Kaatz S, Smart RC, Macfarlane D., Ginsberg JS. Detection of Pulmonary Emboli With 99mTc-Labeled Anti-D-dimer (DI-80B3)Fab’ Fragments (ThromboView) American Journal of Respiratory and Critical Care Medicine, 2011, 184:708-714

OTHER PUBLISHED MATERIAL

Book Chapter

Smart RC. Dosimetry of radiopharmaceuticals for diagnostic and therapeutic nuclear medicine. Concepts and Trends in Medical Radiation Dosimetry. AIP Conf Proc 1345, 36-47 (2011); doi:10.1063/1.3576158, American Institute of Physics, 2011

Butler, P., Quinn, R., Beuzeville, S. and Nour, R. Clinical Nuclear Medicine Handbook (4th Edition) www.stgsnuclearmedicine.com This lists the indications and interpretation for commonly performed nuclear medicine investigations and is also available on the internet (www.stgsnuclearmedicine.com).

73 PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

Smart RC. The CT in PET/CT and SPECT/CT – much ado about dose. ACT Branch meeting of the ANZSNM, Canberra, 19.05.2010

Smart RC. Dosimetry of Radiopharmaceuticals for Diagnostic and Therapeutic Nuclear Medicine Solid State Dosimetry 16, Summer School, Wollongong University, 15.09.10

Smart RC. RPS8 Five years on. Australasian Radiation Protection Society, Adelaide, October 2010

Asha S, Grant N, Curtis K, Smart R, Compagnoni K. Comparison of radiation exposure of trauma patients from diagnostic radiology before and after the introduction of a panscan protocol. Australasian College for Emergency Medicine, Canberra, November 2010

McKay E. Simulation Assisted Quantitation of I-131 Distribution. ANZSNM Annual Scientiﬁc Meeting, April 2010, Auckland.

McKay E. GRNT: A Geant4 Code for Radionuclide Therapy Dosimetry. University of Wollongong, Geant4 Workshop, March 2011, Wollongong.

McKay E. MrVoxel: cross platform software for radionuclide therapy dosimetry. ANZSNM Annual Scientiﬁc Meeting, May 2011, Darwin.

COMMUNITY ENGAGEMENT

Each monthly issue of the St. George Division of General Practice Newsletter contains a nuclear medicine case with the focus being on a common clinical conditions seen in general practice.

74 DEPARTMENT OF NEUROLOGY

DEPARTMENTAL STAFF

Mark Hersch BSc, MBBCh, PhD, FRACP, Conjoint Associate Professor UNSW Louise Allport BSc (Med), MBBS, PhD, FRACP Jerome IP MBBS, FRACP, Conjoint lecturer, UNSW Jane Prosser MBBS, FRACP, PhD Walid Matar BMedSci (Hons), MBBS Donald Pryor MBBS, MD, FRACP

Nursing Melissa Tinsley, Clinical Nurse Consultant, Stroke

RESEARCH GRANTS

None reported

RESEARCH PROJECTS IN PROGRESS

Topic – Avert (A Very Early Rehabilitation Trial) for stroke patients Principal investigators – Nicole Austin (physiotherapy) and Melissa Tinsley

ORIGINAL PEER-REVIEWED PUBLICATIONS

None reported

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

None reported

75 PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

None reported

COMMUNITY ENGAGEMENT

None reported

76 DEPARTMENT OF RENAL MEDICINE

DEPARTMENTAL STAFF

Head of Department Professor Mark Brown MBBS, MD, FRACP (Professor of Medicine, UNSW)

Senior Consultant Staff Associate Professor John Kelly MBBS, MD, FRACP Associate Professor George Mangos MBBS, MD, FRACP Associate Professor Ivor Katz MD, MBBCh, FCP(SA), BSc Honours, PhD, FRACP Dr William Chan MBBS, PhD, FRACP Dr Sharon Ong BSc (Med), MBBS, PhD, FRACP (Conjoint Senior Lecturer, UNSW) Dr Parthasarathy Shanmugasundaram MBBS, DM, FRACP (Conjoint Lecturer, UNSW) Dr Cathie Lane B.Pharm. B.Med FRACP,Grad Cert ULT, PhD (Conjoint Lecturer, UNSW) Dr Frank Brennan MBBS, FRACP, FAChPM, LLB Consultant Palliative Care Medicine

Junior Medical Staff (Advanced Trainees & Registrars) Advanced Trainees 2011 Ajay Purushotam Franziska Pettit Lisa Phipps Rachel Chalmers Shadi Alzalnia Teresa Chang

Registrars 2011 Chris Middlemiss Anthony Phang Shadi Afzalnia

Advanced Trainees 2010 Franziska Pettit Jennifer Robins Tim Pianta

Registrars 2010 Anthony Stanley Elizabeth Shiner Michelle Julien Sunil Bhatia

77 Research Staff Research Fellow Franziska Pettit Julia Spaan

Research Ofﬁcer Saiyini Pirabhahar BNurs, MHlthSci, Grad Dip Med Lab Sci Gemma Collett BMedSc

Research Assistant Belinda Trajkovska BA, PG DIP Psych

Nursing & Allied Health Research Staff Elizabeth Josland Grad Dip Nurs, MPH Jennifer Beddoe BNurs, Grad. Dip. Mid Lynne Roberts RN, MMid, MHlthSci

RESEARCH GRANTS

Source: St George Medical Research Foundation Project Grant $50000 (2010) Principal investigator: Dr Sharon Ong Project title: Masked Hypertension in Chronic Kidney Disease, dialysis and renal transplant patients. Total awarded & years funded: 50,000 2009-2010

78 RESEARCH PROJECTS IN PROGRESS

Title Investigators

Hypertension in Chronic Kidney Disease (CKD) Ong SLH, Brown MA, Kelly JJ and Masked hypertension in CKD, transplantation and peritoneal dialysis Mangos GJ

CKD health systems research Brown MA, and Katz IJ Achievement of Target BP & other risk factors on CKD patients

Patterns of referral for CKD Management Katz IJ and Brown MA

hsTroponin T in Haemodialysis and CKD patients Katz IJ and Brown MA

BP methodology Brown MA, Mangos GJ Validation of currently available BP monitoring devices with ABPM

Accuracy of home BP devices Brown MA, Mangos GJ

Hypertension in Pregnancy Mangos GJ The ‘new’ R-A-A system in pre-eclampsia

Validation of Omron & Liquid crystal BP devices in hypertensive pregnancy Davis G and Brown MA

Body composition in Normal Pregnancy Mangos GJ and Brown MA

OPRA- predictive value of ultrasound and other factors in high risk pregnancies Davis G and Brown MA

Renal Palliative Care The role of palliative care in improving quality of life outcomes for hospital based Brennan F and Brown MA haemodialysis patients

Quality of Life & Symptom burden in dialysis patients Brennan F and Brown MA

Outcomes of patients in pre-dialysis & supportive care clinics Brennan F

Retrospective and prospective studies of the effects of a Renal Palliative care Prof Mark Brown service on patients with CKD stage 4/5 and their carers.

Nutrition in CKD Relationship between nutritional status and outcome in End Stage Kidney Chan M, Brown MA Disease Research Collaboration A randomised, controlled trial of exit site application of MedihoneyTM Ong S Antibacterial Wound Gel for the prevention of catheter-associated infections in peritoneal dialysis patients (Australian Kidney Trials Network)

79 ORIGINAL PEER-REVIEWED PUBLICATIONS

2011

Avesani CM, Trolonge S, Deleaval P, Baria F, Mafra D, Faxen-Irving G, Chauveau P, Teta D, Kamimura MA, Cuppari L, Chan M, Heimburger O and Fouque D. Physical activity and energy expenditure in haemaodialysis patients: an international survey. Nephrol Dial Transplant. 2011:0:1-5

Brown MA, Masterson R. Renal Palliative care in Australia: time to engage. Nephrology. 2011;16: 2-3.

Brown MA, Roberts L, Davis G, Mangos G. Can we use the Omron T9P automated blood pressure monitor in pregnancy? Hypertens Pregnancy. 2011; 30:188-193.

Burns T & Smyth A. Reducing aggression in the haemodialysis unit by improving the dialysis experience for patients. Renal Society of Australasia Journal, 2011: 7(2), 79-89

Canney M, Liu E, Vonthethoff L, Weatherall C, Ong SLH. The nephrotic syndrome and hepatitis due to acquired syphilis: an uncommon presentation of a re-emerging disease. NDT Plus 2011; 4(1): 67-70.

Chan M, Patwardhan A, Ryan C, Chandban S, Westgarth F, and Fry K. Evidence – based Guidelines for the Nutritional Management of Adult Kidney Transplant Receipients. J Renal Nutr, 2011:21 (1), 47-51

Cheema B, Abas H, Smith B, O’Sullivan AJ, Chan M, Patwardhan A, Kelly J, et al. Effect of resistance training during hemodialysis on circulating cytokines: a randomized controlled trial. J Renal Nutr, 2011;21 (1): 47-51

Lane CA, Brown MA. Alignment of Nephrology Training with Workforce, Patient, and Educational Needs: An Evidence Based Proposal. Clin J Am Soc Nephro. 2011; 2681-2687.

80 Macginley R & Mangos GJ. Renal Artery stenosis and hypertension: whom and how to screen and treat. Modern Medicine. 2011; 28: 18-25.

Mangos GJ & Pokorny CS. Investigation of the patient with hypertension. Modern Medicine South Africa. 2011: 22-32

Ong SLH, Whitworth JA. How do glucocorticoids cause hypertension: role of nitric oxide deﬁciency, oxidative stress and eicosanoids. Clin of North Am 2011; 40(2):393-407.

2010

Brennan FP. A Short Talk on Hope. Journal of Illness, Crisis and Loss 2010; 18(3): 259-261.

Brown MA, Roberts L, Davis G, Mangos G. Can we use the Omron T9P automated blood pressure monitor in pregnancy? Hypertens Pregnancy 2010. Early Online: 1–6. DOI: 10.3109/10641955.2010.507854

Chadban S, Howell M, Twigg, S, Thomas, M, Mangos GJ, et al. Assessment of kidney function in type 2 diabetes. Nephrology 2010 15: s146 - s161.

Chadban S, Howell, M, Twigg, S, Thomas, M, Mangos GJ, et al. Cost-effectiveness and socioeconomic implications of prevention and management of chronic kidney disease in type 2 diabetes. Nephrology 2010; 15: s195 - s203.

Chadban, S, Howell, M, Twigg, S, Thomas, M, Mangos GJ, et al. Prevention and management of chronic kidney disease in type 2 diabetes. Nephrology 2010; 15: s162 - s194.

Head GA, Mihailidou AS, Duggan KA, Beilin LJ, Berry N, Brown MA et al. Ambulatory Blood Pressure working group of the High Blood Pressure Research Council of Australia. Deﬁnition of ambulatory blood pressure targets for diagnosis and treatment of hypertension in relation to clinic blood pressure: prospective cohort study. Brit Med J 2010; 340:c1104.

Katz IJ, T.E. Gerntholtz, M. van Deventer, H. Schneider and Naicker S. Is there a need for early detection programs for chronic kidney disease? Clinical Nephrology 2010; 74(Suppl 1).

81 Kumar, K, Macginley, R, Mantha, M, Mount, P, Mangos GJ, et al. Natural history and progression of atherosclerotic renal vascular stenosis. Nephrology 2010; 15: s204 - s209.

Macginley, R, Kumar, K, Mantha, M, Mount, P, Mangos GJ, et al. Endovascular treatment. Nephrology 2010; 15:s210 - s217.

Macginley, R, & Mangos, GJ. Renal Artery Stenosis and Hypertension: Whom and How to Screen and Treat. Medicine Today 2010; 11: 22 - 30.

Mantha, M, Kumar, K, Macginley, R, Mount, P, Mangos GJ, et al. Screening tests for diagnosis of renal artery stenosis. Nephrology 2010; 15: s218 - s226.

Martin A, Brown MA. Uric acid in Pre-eclampsia: an old villain with new functions? Nat Rev Nephrol 2010; 6: 744-748.

Mount, P, Kumar, K, Macginley, R, Mantha, M, Mangos GJ, et al. Inhibition of the renin-angiotensin system. Nephrology 2010; 15: S234 - S243.

Ritchie A, Brown MA. Proteinuria in pre-eclampsia – from bench to bedside. Fetal. Medicine Review 2010.

Roberts M, Kumar K, Macginley R, Mantha M, Mangos GJ, et al. Role of distal protection devices. Nephrology 2010; 15: s227 - s233.

Thida M, Earl J, Zhao Y, Wang H, Tse CS, Vickers JJ, Sutton M, Ong SLH, Mori TA, Croft KD, Whitworth JA, Zhang Y. Effects of sepiapterin supplementation and NOS inhibition on glucocorticoid-induced hypertension. Am J Hypertens 2010; 23(5): 569-574.

82 OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

Brown MA. Chapter 43: Pregnancy with pre-existing renal disease In: Floege J, Johnson RJ, Feehally J (eds). Comprehensive Clinical Nephrology. Elsevier Saunders. St Louis. Missouri. USA. 2010 : 516-528.

Brown, MA. Chapter 7: Renal Disease in Pregnancy In: Powrie RO, Greene MF, Camann W (eds) de Swiet’s Medical Disorders of Obstetric Practice 5th edition.Wiley-Blackwell.UK. 2010:182-208

Brown MA, Mangos G, Peek M, Plaat F. Chapter 7: Renal Disease in Pregnancy In : Powrie RO, Greene MF, Camann W (eds) de Swiet’s Medical Disorders of Obstetric Practice 5th edition Wiley-Blackwell.UK. 2010:182-208

Brown MA Chapter 43. Pregnancy with pre-existing renal disease In: Floege J, Johnson RJ, Feehally J (eds). Comprehensive Clinical Nephrology. Elsevier Saunders. St Louis. Missouri. USA. 2010 : 516-528

Eastabrook G, Brown MA, Sargent I. The Origins and End-Organ Consequences of Pre-eclampsia In: Von Dadelzen P, Magee L (eds): Best Practice & Research Clinical Obstetrics & Gynaecology: Hypertension in Pregnancy (Issue 25.4). 2011: 435 – 447.

Ong SLH, Brown MA. MIMS Disease Index (eMIMS) 2010. Hypertensive disorders in pregnancy.

Peek M, Mangos GJ, Brown MA. Chapter 49: Approach to fetal assessment, optimization of neonatal outcome, mode of delivery and timing for non-obstetric readers In: Powrie RO, Greene MF, Camann W, eds. de Swiet’s Medical Disorders of Obstetric Practice. 5th edition. UK:Wiley-Blackwell; 2010:749-53.

83 PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

2011

Brennan F. Symptom Management in ESRD. Australian and New Zealand Society of Palliative Medicine (ANZSPM) Fora. Hamilton New Zealand April 2011

Brennan F. Update on Renal Palliative Care. Annual Conference of the New Zealand Branch of the Australian and New Zealand Society of Palliative Medicine (ANZSPM), Wellington, New Zealand April 2011

Brennan F. Renal Palliative Care- An Overview. Cuisle Beatha International Palliative Care Conference, Galway, Ireland. Oct 2011

Brennan F. Advance Care Planning in ESRD. Renal Society of Australasia (RSA) Conference, Palmerston North, New Zealand. Nov 2011

Brown MA. Chairman, Pregnancy: Proteinuria, the glomerular basement membrane, and pre- eclampsia. World Congress of Nephrology. Vancouver. Canada. 8-12th April 2011

Brown MA. Chairman, Pregnancy and renal disease: predisposition, management and outcomes. World Congress of Nephrology. Vancouver. Canada. 8-12th April 2011

Chan M. Nutrition and Metabolism in Renal disease, Annual update.: Nutrition and Transplantation, Nutritional management in Haemodialysis and Nutritional in Pre-Dialysis CKD. Mexico City, Mexico, May 2011.

Chan M. Renal nutrition workshop, National Kidney Foundation, Kuala Lumpur, Malaysia, June, 2011.

Chan M. Nutrition assessment in renal failure, Pre-conference workshop, International society of blood puriﬁcation (ISBP), ASM, Beijing, September 2011

2010

Brown MA. Pre-eclampsia update 2010. 3rd International Nephrology Conference. Brunei Darussalam. June 26-27 2010. ( ISN invited speaker)

Brown MA. Dialysis and transplantation in Pregnancy. 3rd International Nephrology Conference. Brunei Darussalam. June 26-27 2010. ( ISN invited speaker)

84 National

2011

Afzalnia S. Weatherall C, Millar E, Katz I. Case Report: Neutropenic Fever with BK Virus Nephropathy and Cytomegalovirus Infection in a Renal Transplant Patient. Oral poster presentation at the Australian and New Zealand Society of Nephrology, Adelaide, September 2011

Brennan F. Creation of a Renal Supportive Care Service. Department of Renal Medicine, Royal Brisbane Hospital, Brisbane. Jan 2011

Brennan F Renal Supportive Care – An Overview. Kidney Club, Nephrologists, Brisbane, Queensland. Jan 2011

Brennan F. Renal Supportive Care – An Overview and Role of the General Practitioner Grand Rounds Tamworth Base Hospital, Tamworth. Mar 2011

Brennan F. Symptom Management in ESRD. Renal Palliative Care Education Day, Dubbo Mar 2011

Brennan F. What is Palliative Care ? - Renal Supportive Care – An Overview. DNT Meeting, Hunter Valley. Mar 2011

Brennan F. Uraemic Pruritus – Pathogenesis and Management. NSW Palliative Care Education Day, Royal Prince Alfred Hospital May 2011

Brennan F. “Palliative Care for all” – Palliative Care in the non-malignant setting. Newcastle Palliative Care Education Day, Newcastle, NSW Jun 2011

Brennan F. Symptom Management in ESRD. Australian and New Zealand Society of Palliative Medicine (ANZSPM) Medical and Surgical Updates. St Vincent’s Hospital, Melbourne. Jul 2011

Brennan F. Update on Renal Palliative Care. Department of Renal Medicine, Liverpool Hospital, Liverpool, Sydney Oct 2011

Brennan F. Renal Palliative Car. Wagga Wagga Base Hospital, Wagga Wagga. Oct 2011

Brown MA. Chairman, Pregnancy: Proteinuria, the glomerular basement membrane, and pre- eclampsia. World Congress of Nephrology. Vancouver. Canada. 8-12th April 2011

Brown MA. Chairman, Pregnancy and renal disease: predisposition, management and outcomes. World Congress of Nephrology. Vancouver. Canada. 8-12th April 2011

Josland E. Quality of Life and Symptom Management in end stage renal disease. Renal Society of Australasia 39th Annual Conference, Adelaide. Jun 2011.

Josland E. Quality of Life in renal failure. Division of General Practice, Broken Hill. Jul 2011

85 Josland E. Pre Dialysis Assessment and discussions. Palliative Care Education Day. Broken Hill. Jul 2011

Josland E. Supportive Care Workshop. St George Hospital Renal Supportive Care Symposium. Aug 2011.

Josland E. Conservative Care in ESKD & Symptom management in ESKD. Launceston. Nov 2011.

Mangos GJ. Dawn of Generation Risk: Managing the CV risk epidemic in our ageing population. MICARE, Lugarno, Sydney, July 2011.

Mangos GJ. Early detection of Chronic Kidney Disease (CKD): How to best detect CKD with reference to Urine albumin:protein detection. Sydney General Practitioner Conference and Exhibition. May 2011

Mangos GJ. Management of Renal Artery Stenosis’ 11th Annual ANZ Society of Nephrology Postgraduate Meeting May 2011, Gold Coast.

Mangos GJ. Training Issues. DNT workshop. Pokolbin, 2011 NSW

Ong SLH, Trajkovska B, Cohen S, Kelly JJ, Mangos GJ, Pirabhahar S, Brown MA. How should blood pressure be assessed in CKD patients? A pilot study of “Masked Hypertension”. Oral poster presentation at the Australian and New Zealand Society of Nephrology, Adelaide, September 2011

Ong SLH “Hypertension” Masterclass in Nephrology, NSW Health Nephrology Workforce Education & Training Group. Jan 2011

Ong SLH “Management of resistant hypertension” General Practice Conference and Education Workshop, Sydney May 2011

Ong SLH “Glucocorticoid-induced hypertension” St George Hospital Academic Department of Medicine Medical Grand Rounds. Sep 2011

Pettit F., Shanmugasundaram P.,Brown M. Acute intermittent porphyria (AIP) in early pregnancy with hyponatraemia and renal impairment. 47th Annual Scientiﬁc meeting of the ANZSN at Adelaide on September 2011

Phipps L. Katz I, Josland E, Zekry A, Brown M. Evaluation of protocols and practices for the surveillance and prevention of Hepatitis B virus on haemodialysis. Oral poster presentation at the Australian and New Zealand Society of Nephrology, Adelaide, September 2011

86 2010

Brennan F. Renal Supportive Care – An Overview. Grand Rounds Prince of Wales Hospital, Sydney Feb 2010

Brennan F. Renal Medicine and Palliative Care – A Marriage of Two Specialties & Symptom Management in ESRD. Renal Palliative Care Symposium, St George Hospital Aug 2010. Brennan F. Renal Supportive Care – An Overview & Symptom Management in ESRD. Pre-Conference Workshop on Renal Palliative Care. Australian and New Zealand Society of Nephrology Conference, Perth Sep 2010.

Brennan F. Renal Supportive Care – An Update. NSW Palliative Care Education Day, Royal Prince Alfred Hospital. May 2010

Brown MA. Renal palliative care; Education models for trainees. Australia-UK-Canada Clinical exchange: perspectives in CKD care. Adelaide. SA. March 15th – 18th. 2010.

Brown MA. Pregnancy in Dialysis & transplantation. 10th Annual ANZSN Postgraduate meeting. Gold Coast. Qld. 28-30th May 2010.

Brown MA. Pre-eclampsia and eclampsia in 2010. College of Intensive Care Medicine of Australia & New Zealand. 2010 Annual Scientiﬁc meeting. 4-6 June 2010.

Brown MA. Renal Palliative care. ANZSN Palliative care seminar. Perth. 12th September 2010.

Brown MA, Pirabhahar S, Kelly J, Mangos G, Mackenzie C, McConachie P, Butler P. Is estimated GFR (eGFR) always a valid method for assessing renal function? ANZSN 46th Annual Scientiﬁc Meeting. Perth. WA. Sept 12th – 15th 2010

Brown MA. Annual SOMANZ hypothetical – SLE in pregnancy. ISOM 5th International Scientiﬁc meeting. Melbourne. Vic. 1-3rd October. 2010.

Brown MA. State of the Art lecture: Management of pre-eclampsia: what we think we know. 17th ISSHP World Congress. Melbourne. Vic. 3-6th October. 2010

Brown MA. Ambulatory blood pressure in Pregnancy. HBPRCA workshop. Annual Scientiﬁc meeting HBPRCA. Melbourne. Dec 1-3 2010.

Canney M, Liu E, Vonthethoff L, Millar E, Weatherall C, Ong SLH. Nephrotic syndrome secondary to Treponema pallidum. Oral poster presentation at the Australian and New Zealand Society of Nephrology, Perth, September 2010.

Foote C, Tranter S, Josland E, Jardine M, Cass A, Brennan F, Brown MA. Symptom burden in a palliative nephrology clinic. Australian and New Zealand Society of Nephrology, 46th Annual Scientiﬁc Meeting. Perth. WA. Sept 12th – 15th 2010.

87 Josland E. The Evolving integration of Palliative Care into End Stage Renal Failure Management. Pre-Conference Workshop on Renal Palliative Care. Australian and New Zealand Society of Nephrology Conference, Perth Sep 2010

Katz I, Gill A, Brein L, Harvey M, Millar E, Brown MA. Athrombocytopenic microangiopathy and renal failure. Australian and New Zealand Society of Nephrology, 46th Annual Scientiﬁc Meeting, Perth. WA. Sept 12th – 15th 2010. Lane C, Brown MA. What makes the ‘ideal’ nephrologist? A new basis for training and assessment. Australian and New Zealand Society of Nephrology, 46th Annual Scientiﬁc Meeting. Perth. WA. Sept 12th – 15th 2010.

Ong SLH “Mechanism of dexamethasone-induced hypertension” Hypertension: Research, Practice and Policy. Festschrift for Prof Judith Whitworth. Dec 2010

Ram J, Mangos G, Brown MA. The effect of cuff size on automated blood pressure measurement in pregnant and non-pregnant individuals. Australian and New Zealand Society of Nephrology, 46th Annual Scientiﬁc Meeting. Perth. WA. Sept 12th – 15th2010

COMMUNITY ENGAGEMENT

None reported.

88 DEPARTMENT OF RESPIRATORY MEDICINE AND SLEEP DISORDERS

DEPARTMENTAL STAFF* 2011

Head of Department Steven Lindstrom, MBBS (Hons), FRACP (Infectious Disease & Respiratory Medicine) VMO: St George Private, Kareena Private Hospital. Conjoint Lecturer University NSW

Senior Staff Specialists Elizabeth Clark, MRCP FRCP, MBBS (Hons), St George Private,

Andrew Ng, FRCP, MBBS (Hons), St George Private, Kareena, The Sutherland Hospital

Con Archis, MBBS (Hons), Staff Specialist at The Sutherland Hospital, VMO at St George Private and Kareena Private Hospitals, Clinical Lecturer University NSW (conjoint staff specialist)

John Moses, MBBS, FRACP, St George Private Hospital, Conjoint lecturer University NSW

Staff Specialists Veronica Yozghatlian, MBBS, FRACP, VMO: Royal Prince Alfred

Frank Yan, Sc (Med) MBBS, FRACP, Consultant Physician Allergy, Respiratory & Sleep Medicine: St George Private Hospital, VMO: Royal Prince Alfred, St Lukes

Visiting Medical Ofﬁcers Hazel GOLDBERG, MBBS, FRACP VMO: Prince of Wales Sydney Hospital, Royal Prince Alfred

Junior Medical Staff Vocational Registrars Advanced trainees Saidul Ansary, MBBS Haider Naqvi, MBBS Marissa Antony, MBBS, MRCP

89 Research Staff Senior Research Staff Jay Flack, BSc

Research Assistants Cynthia Higgins, BASc (Nursing) Linda O’Malley, R.N., C.M. Carol Gano, MND, BSc.

DEPARTMENTAL STAFF* 2010

Head of Department Steven Lindstrom, MBBS (Hons), FRACP (Infectious Disease & Respiratory Medicine VMO: St George Private, Kareena Private Hospital Conjoint Lecturer UNSW

Senior Staff Specialists John Moses, MBBS, FRACP St George Private Conjoint Lecturer

Andrew Ng, MBBS, FRCP The St George Private Hospital, Kareena, The Sutherland Hospital Conjoint Lecturer University NSW

Elizabeth Clark, MRCP, FRCP, MBBS (Hons)

Con Archis, MBBS (Hons) Staff Specialist at The Sutherland Hospital, VMO at St George Private and Kareena Private Hospitals. Clinical Lecturer University NSW

Visiting Medical Ofﬁcer Hazel Goldberg, MBBS, FRACP VMO: Prince of Wales, Sydney Hospital, Royal Prince Alfred

90 Junior Medical Staff Vocational registrars Advanced trainees Eric Wong, MBBS Irshad Ali, MBBS, FRACP part I

Research Staff Senior research staff Jay Flack, BSc.

Research assistants /Scientiﬁc Ofﬁcer Cynthia Higgins Carol Gano, MND, BSc.

RESEARCH GRANTS#

Category I - Nationally Competitive Grants:

Included here is research performed within St George Hospital, but where funding is being obtained from other researchers Funding level will not be reported Source NHMRC & The Menzies Foundation, Canada Principal investigators: Dr Guy Marks, Dr Hazel Goldberg Project title: Prevention of Tuberculosis Total awarded; years funded: unknown

Source NHMRC Principal investigators: Prof Warren Britten (Prince Alfred Hospital & The Centenary Institute of Cancer Medicine and Cell) Project title: Immune Response to Tuberculosis Total awarded; years funded: unknown

91 RESEARCH PROJECTS IN PROGRESS

Department Initiated Research Projects in Progress

A Randomised Control Trial to Assess the Efﬁcacy of Procalcitonin in Reducing the Length of Stay and Duration of Antibiotics in Patients with Community Acquired Pneumonia. Application of a department generated decision tree to reduce length of stay and antibiotic need in patients presenting at hospital with pneumonia Dr Steven Lindstrom, Dr Haider Naqvi

A pilot study assessing the role of Procalcitonin in reducing the length of hospital stay in patients admitted with Community Acquired Pneumonia. A preliminary study determining the merit of procalcitonin use for community acquired pneumonia clinical decision making. Dr Steven Lindstrom, Dr Eric Wong

Tuberculosis Clinical Audit Review of clinical cases of tuberculosis at St George Hospital. Dr Irshad Ali, Dr Hazel Goldberg

Cardiopulmonary exercise testing and quality life assessments in patients with lung cancer undergoing radiotherapy for curative intent. To determine how radiotherapy for lung cancer impacts on exercise tolerance and quality of life scores in patients managed with radiotherapy with or without chemotherapy given with curative intent. Dr Marissa Antony, Dr Steven Lindstrom, Dr Yiauw Chin, Prof Peter Graham

Industry Initiated Research Studies & Trials

Gilead: “GS-US-219-0101 035/061” A Phase 3, double-blind, Multicenter, Randomized, Placebo-Controlled Trial Evaluating Repeated Courses of Aztreonam for Inhalation Solution in Subjects with non-CF Bronchiectasis and Gram- Negative Endobronchial Infection (AIR-BX1). Assess safety and effectiveness of Aztreonam for Inhalation Solution over 30 weeks in non-CF Bronchiectasis and Gram-Negative Endobronchial Infection patients. Lindstrom, S.

Pharmaxis: “DPM-B-305” A Phase III Multicenter, Randomized, Parallel Group, Controlled, Double Blind Study to Investigate the Safety and Efficacy of Inhaled Mannitol over 12 months in the Treatment of Bronchiectasis. Efficacy and Safety of inhaled mannitol in non-cystic fibrosis bronchctasis subjects (2009-closed to recruitment in 2011, but in 2012, still 2 active patients). Lindstrom, S.

92 Hunter Immunology Ltd: “HI-HI005”, HICOPD A Multi-centre, Randomized, Double Blind, Placebo-Controlled, Parallel Group, Single Season Study to Assess the Efficacy and Safety of HI-1640V, an enteric coated oral Vaccine Tablet containing 45 mg H1-164 Active Substance (Inactivated, Whole Cells of Non-typable Haemophilus influenzae, isolate 164) for reducing the Rate and Severity of Acute Exacerbations in Patients with Moderate to Severe Chronic Obstructive Pulmonary Disease (COPD). Efficacy of HI-1640V (enteric-coated) versus placebo in reducing incidence of exacerbations per patient requiring oral/parental corticosteroid treatment or hospitalization. (2010-open, closed in 2012) Clark, E.

Novartis: CQVA149A2303 “A 26-week treatment multi-centre, randomized, double-blind, parallel-group, placebo and active controlled (open label) study to assess the efﬁcacy, safety and tolerability of QVA (110/50 µg q.d.) in patients with moderate to severe chronic obstructive pulmonary disease (COPD). A comparison of the efﬁcacy and safety of indacterol 150 µg once daily with open label tiotropium 18 µg once versus open label tiotropium 18 µg once daily in moderate-to-severe COPD patients (2008-2010). Archis, C.

Woolcock Institute for Medical Research (awarded NHMRC funding) Diagnosis of Obstructive Sleep Apnoea in Primary Care. A study into facial structure and OSA, plus attempts to improve GP referral to hospital-based sleep studies in the Diagnosis of Obstructive Sleep Apnea (2008- 2011) Ng, A.

The Einstein VTE Trial (Bayer Pharmaceuticals Funded study) Joint Haematology and Respiratory trial, see CCC Report Roz Ristuccia Prof Beng Chong Dr Con Archis (PI)

93 ORIGINAL PEER-REVIEWED PUBLICATIONS

Sutherland K. Deane SA, Chan ASL, Schwab RJ, Ng AT, Darendeliler MA, Cistulli PA. Comparative Effects of Two Oral Appliances on Upper Airway Structure in Obstructive Sleep Apnea. Sleep 2011;34: 469-477.

Sutherland K, Petocz P, Chan A, Darendeliler MA, Qian J, Ng A, Cistulli P. Multimodal assessments improve prediction of oral appliance treatment outcome in OSA: potential importance of patient phenotype. J Sleep Res 2011;20 (Suppl.1):p.42.

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews) None reported

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

Australian Sleep Association 23rd Annual Meeting, Sydney 2011 “Sleep Dowunder: Sleep and the City” Sutherland K, Petocz P, Chan A, Darendeliler MA, Qian J, Ng A, Cistulli P. Presentation: Multimodal assessments improve prediction of oral appliance treatment outcome in OSA: potential importance of patient phenotype.

Thoracic Society of Australia and New Zealand, Annual Scientiﬁc Meeting, Brisbane 2010 Wong, E., Linstrom, S. “The Use of Procalcitonin in Community Acquired Pneumonia” (Poster)

Ali, I., Goldberg, H “The Tuberculosis Clinical Audit Project” (Poster)

Ali, I. “Effects of Bariatric Surgery on Morbidly Obese Patients with OSA” (Poster).

COMMUNITY ENGAGEMENT World COPD Day Dinner & Lecture Presented by Dr Steven Lindstrom for local General Practitioners, 28 June, 2010

94 DEPARTMENT OF RHEUMATOLOGY, ST GEORGE HOSPITAL

DEPARTMENTAL STAFF*

Head of Department A/Prof Allan Sturgess MB BS (UQld), PhD (UMelb), FRACP, FRCPA Senior Staff Specialist, Conjoint A/Prof Medicine UNSW

Senior Medical Staff Prof Marissa Lassere MB BS (USyd), PhD (UNSW), Grad Dip Epi (Newcastle), FRACP, FAFPHM. Senior Staff Specialist, Conjoint Prof. Medicine UNSW.

Dr Bill Giannakopoulos BSci (Med), MB BS (UNSW), PhD (UNSW), FRACP Senior Lecturer in Medicine UNSW. Consultant Rheumatologist St George Hospital.

Dr Ian Portek MB BS (USyd), FRACP VMO Rheumatology, St George Hospital

Dr Lou McGuigan MB BS (UNSW), MD (UNSW), FRACP VMO Rheumatology, St George Hospital

Junior Medical Staff Dr Barry Kane, Advanced Trainee Rheumatology, 2010 Dr Anne Chung, Advanced Trainee Rheumatology, 2011

Senior Research Staff Sue Baker BAppSc (Biomed) (UTS) Tanya Thompson BSc (UNSW) Steve Lazar BMed Sci

Nursing Research Staff Wendy Gellately RN

Research Allied Health Guni Hinchey Grad Dip Sports (Germ.), Grad Dip Physio (Germ.) Cathy Brand (B Sci Anatomy), Postgrad Dip Physio Wendy Uptin BPhysio

95 RESEARCH GRANTS

NHMRC Enabling Grant 384330 2006-2010 $1.25M Australian Rheumatology Association Database Buchbinder R, March L, Lassere MN, Reid C

NHMRC Project Grant 455467 2007-2011. $665,500 Electronic portable health ﬁle (PHF) to promote quality of care and workﬂow through continuity of care. Lassere MN, Sara T, Johnson K, Iedema R, Rubin G, Macauley V

NHMRC Project Grant 510272 2008-2010 $510, 000 Levels of evidence for surrogate therapeutics Lassere MN, Johnson KR, Dunsmuir W, Galbraith S, Ward R, Hughes M

SGSMRF Establishment Grant The role of B2GP1 in lupus and atherosclerosis Bill Giannakopoulos

NHMRC grants with Prof Steve Krilis, Department of Immunology See separate report of Department of Immunology

Research Projects in Progress Predictors of cardiovascular mortality and morbidity in RA Lassere M, Edmonds J, Sturgess A, Rappo J, McGuigan L

The role of informal carers in arthritis. Lassere M, Edmonds J, Portek I, Sturgess A, Rappo J

Secular Changes in health-related quality of life over two decades in patients with RA. Lassere M, Edmonds J, Portek I, Rappo J, McGuigan L

Development and implementation of a national set of RA quality indicators Lassere M, Johnson K

The development of the Tolerability and Safety Index (TASI) : A summary single score measure of the ascertainment and reporting of tolerability and safety for indirect trial comparisons. Lassere M, Johnson K, Fintein S, Rappo J, Balasingam D, Day R, Tugwell P, Anderson J

Examination of multiple factors inﬂuencing the use of patient-held portable health ﬁle (PHF). Lassere M, Sara T, Johnson K, Baker S

Evaluation of cytokine expression in knee synovium and blood. Lassere M, Edmonds J, Portek I.

An RCT of a treat-to-target strategy versus usual care in RA. Lassere M, Edmonds J, Portek I, Johnson K.

96 Mechanisms underlying the involvement of beta 2 GP1 in SLE and APS Giannakopoulos B, Krilis S

Role of post-translational modiﬁcations of beta2 GP1 in coagulation Giannakopoulos B, Krilis S

Interaction between beta2 GP1 and TLR7 in murine lupus Giannakopoulos B, Krilis S

Detection and signiﬁcance of membrane bound light chains in SLE and RA. Sturgess A

ORIGINAL PEER REVIEWED PUBLICATIONS

Novel assays of thrombogenic pathogenicity in the antiphospholipid syndrome based on the detection of molecular oxidative modiﬁcation of the major autoantigen beta2-glycoprotein I. Ioannou Y. Zhang JY. Qi M. Gao L. Qi JC. Yu DM. Lau H. Sturgess AD. Vlachoyiannopoulos PG. Moutsopoulos HM. Rahman A. Pericleous C. Atsumi T. Koike T. Heritier S. Giannakopoulos B. Krilis SA. Arthritis & Rheumatism. 2011, 63(9):2774-82.

Redox control of beta2-glycoprotein I-von Willebrand factor interaction by thioredoxin-1. Passam FH. Rahgozar S. Qi M. Raftery MJ. Wong JW. Tanaka K. Ioannou Y. Zhang JY. Gemmell R. Qi JC. Giannakopoulos B. Hughes WE. Hogg PJ. Krilis SA. J. Thrombosis & Haemostasis. 2010, 8(8):1754-62.

Beta 2 glycoprotein 1 is a substrate of thiol oxidoreductases. Passam FH. Rahgozar S. Qi M. Raftery MJ. Wong JW. Tanaka K. Ioannou Y. Zhang JY. Gemmell R. Qi JC. Giannakopoulos B. Hughes WE. Hogg PJ. Krilis SA. Blood. 2010, 116(11):1995-7.

Molecular pathophysiology of the antiphospholipid syndrome: the role of oxidative post- translational modiﬁcation of beta 2 glycoprotein I. [Review] Passam FH. Giannakopoulos B. Mirarabshahi P. Krilis SA. Journal of Thrombosis & Haemostasis. 9 Suppl 1:275-82, 2011 Jul.

Insights into the biology and pathobiology of beta2-glycoprotein I. [Review] Giannakopoulos B. Mirarabshahi P. Krilis SA. Current Rheumatology Reports. 2010, 13(1):90-5.

Naturally occurring free thiols within beta 2-glycoprotein I in vivo: nitrosylation, redox modiﬁcation by endothelial cells, and regulation of oxidative stress-induced cell injury. Ioannou Y. Zhang JY. Passam FH. Rahgozar S. Qi JC. Giannakopoulos B. Qi M. Yu P. Yu DM. Hogg PJ. Krilis SA. 2010, Blood 116(11);1961-70.

A pathway and approach to biomarker validation and qualiﬁcation for osteoarthritis clinical trials. Hunter DJ. Losina E. Guermazi A. Burstein D. Lassere MN. Kraus V. Current Drug Targets. 2010, 11(5):536-45.

97 Clinicians adopting evidence based guidelines: a case study with thromboprophylaxis. Chapman NH. Lazar SP. Fry M. Lassere MN. Chong BH. BMC Health Services Research. 2011, 11:240.

The Australian Rheumatology Association Database (ARAD). Williams MP. Buchbinder R. March L. Lassere M. Seminars in Arthritis & Rheumatism. 2011, 40(4):e2-3.

Health-related quality of life and continuation rate on ﬁrst-line anti-tumour necrosis factor therapy among rheumatoid arthritis patients from the Australian Rheumatology Association Database. Staples MP. March L. Lassere M. Reid C. Buchbinder R. Rheumatology. 2011, 50(1):166-75.

Rheumatoid arthritis. Carmona L. Cross M. Williams B. Lassere M. March L. Best Practice & Research in Clinical Rheumatology. 2010, 24(6):733-45.

Patient perceptions of carrying their own health information: approaches towards responsibility and playing an active role in their own health - implications for a patient-held health ﬁle. Forsyth R. Maddock CA. Iedema RA. Lassere M. Health Expectations. 2010, 13(4):416-26.

Are reporting standards of diagnostic test evaluation unrealistic? Lassere M. J. Rheumatology. 2010, 37(2):220-2.

OTHER PUBLISHED MATERIAL

None reported

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

None reported

COMMUNITY ENGAGEMENT

A/Prof Allan Sturgess is patron of the patient self-help group Myositis Australia

98 SURGERY, PERIOPERATIVE & CANCER SERV ICES

SURGERY DEPARTMENT OF CARDIOTHORACIC SURGERY

DEPARTMENTAL STAFF*

Head of Department Dr Gary Fermanis MBBS (Hons) FRACS

Visiting Medical Ofﬁcers Dr Con Manganas MBBS FRACS Dr Matthew Horton MBBS FRACS

Junior Medical Staff Sheen Peeceeyen MCh Christopher Cao MBBS, BSc (Med) James Boyd

Senior Research Staff Dr Christopher Cao

Nursing Research Staff Patricia Newbon, RN

RESEARCH GRANTS#

Clinical Excellence Commission - $70,000. Funding for a database manager, for the year 2010 to support submission of all our outcome data, concerning cardiac surgery, to a centralised database where it is benchmarked against other units in NSW and throughout Australia, for quality control.

99 RESEARCH PROJECTS IN PROGRESS

Title Investigators

Radial Artery versus Saphenous Vein in Coronary Artery Bypass Graft Surgery – Christopher Cao Current Level IA Evidence

A Systematic Review of Robotic Video-Assisted Thoracic Surgery for Non-Small Cell Christopher Cao Lung Cancer

Video-Assisted Thoracic Surgery versus Open Thoracotomy for Non-Small Cell Christopher Cao Lung Cancer: A Meta-analysis of Propensity-matched Studies

ORIGINAL PEER-REVIEWED PUBLICATIONS

Critical Review of Revascularization Techniques for Left Main Coronary Artery Disease. Cao C, Manganas C, Peeceeyen S, Bannon P, Yan T. Eur Heart J published online November 13, 2011. Available at: http://eurheartj.oxfordjournals.org/content/32/17/2125.abstract/reply#ehj_el_1038

OTHER PUBLISHED MATERIAL

None reported

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

Presentations ASCTS Annual Scientiﬁc Meeting, Hamilton Island, Australia, 5 November 2010 Presenter: Christopher Cao 1. Bronchopulmonary Carcinoid Tumors: Long Term Outcomes Following Resection (Oral) 2. Staging for Patients with Malignant Pleural Mesothelioma after Extrapleural Pneumonectomy (Oral) 3. A Systematic Review of Extrapleural Pneumonectomy for Malignant Pleural Mesothelioma (Oral) 4. Selection of Patients with Malignant Pleural Mesothelioma for Extrapleural Pneumonectomy (Oral)

ASCTS Annual Scientiﬁc Meeting, Queenstown, NZ, 8 August 2011 Presenter: Christopher Cao Video-assisted Thoracic Surgery Versus Open Thoracotomy for Non-small Cell Lung Cancer – A Propensity Score Analysis Based on a Multi-institutional Registry (Oral)

COMMUNITY ENGAGEMENT

Knights of St George Charity Foundation

100 SURGERY DEPARTMENT OF SURGERY, LIVER AND PERITONECTOMY UNIT

DEPARTMENTAL STAFF*

Head of Department David Lawson Morris MB ChB FRCS MD PhD FRACS (Professor of Surgery, UNSW)

Senior Medical Staff Staff Specialists Seema Bagia MBBS FRACS

Visiting Medical Ofﬁcers Frank Chu MBBS FRACS

Senior Lecturer: Michael Talbot MBCHB, FRACS - 2010 Senior lLecturer: Paul Cozzi MBBS,MS,FRACS

Junior Medical Staff Terence Chua B.Sc.Med. (Hons)

Research Staff Principal Scientist Mohammad Pourgholami (M. Pharm; PhD, MIPS)

Senior Scientist Javed Akhter (PhD) Chief Technical Ofﬁcer Ahmed Mekkway – Post doc.

Research Assistants Samina Badar Hieng Lu - PT

Research students Mahmoud Abdel Aaty (2010) Anahid Ehteda Krishna Pillai Parvin Ataie Farnaz Bahrami Samar Masumi Moghadam

101 Afshin Amini Lubna Hossain Nursing & Allied Health Research Staff Peritonectomy Clinical Nurse Consultants Vanessa Saunders Helen Kennedy

Database Manager/Equipment Technician Jing Zhao

RESEARCH GRANTS#

Category I - Nationally Competitive Grants:

Source: ARC Discovery Grant “DP110102409” Principal investigators: MH Stenzel, DL Morris, MH Pourgholami Project title: Albendazole Polymers Total awarded; years funded: (2011-2014) for $450,000.00

Source: Cancer & Bowel Research Trust Principal investigators: Chua TC, Morris DL, Liauw W Project title: Biomarkers to classify and predict prognosis in appendix cancer Total awarded; years funded: Year 1 - $40,000 and Year 2 - $40,000

Other funding*: UNSW Foundation /David Morris Liver Cancer Research Fund Source: Donations Total (2010): $19,344

Other funding*: UNSW Foundation /David Morris Liver Cancer Research Fund Source: Donations Total (2011): $25,110

102 RESEARCH PROJECTS IN PROGRESS - 2010

Title Investigators

Principal investigators: David Morris, Development and evaluation of new formulations of albendazole for the Martina Stenzel treatment of cancer Others: Mohammad Pourgholami, Elham Nourian Principal investigators: David Morris Improving antitumor efﬁcacy of albendazole Others: Anahid Ehteda, Samina Badar, Mohammad Pourgholami Principal investigators: David Morris Sex hormones and mesothelioma: an experimental investigation in nude mice Others: Krishna Pillai, Mohammad Pourgholami Principal investigators: David Morris Evaluation of minoycline as a potential drug for the treatment of ovarian cancer Others: Parvin Atraie, Samina Badar, Mohammad Pourgholami Principal investigators: David Morris Tetracyclines in the treatment of malignant peritoneal mesothelioma in nude Others: Samina Badar, Krishna Pillai, Javed mice Akhter, Mohammad Pourgholami Principal investigators: David Morris Effect of minocycline on mitochondrial function and cancer cell apoptosis Others: Farnas Bahrami, Samina Badar, Mohammad Pourgholami Principal investigators: David Morris Role of human sprouty in ovarian cancer tumor growth and metastases Others: Samar Masumi, Afshin Amini, Mohammad Pourgholami Principal investigators: David Morris Role of human sprouty in prostate cancer metastases Others: Mahmoud Abdel Aaty, Mohammad Pourgholami Principal investigators: David Morris Interaction of human sprouty with uPAR Others: Ahmed Mekkawy, Mohammad Pourgholami

103 RESEARCH PROJECTS IN PROGRESS - 2011

Title Investigators

Principal investigators: David Morris Effect of minocycline on cancer-induced cytokine and growth factors Others: Parvin Ataie, Samina Badar, Mohammad Pourgholami Principal investigators: David Morris Pharmacological effect of minocycline on tumor growth and malignant ascites Others: Parvin Ataie, Samina Badar, formation Mohammad Pourgholami Principal investigators: David Morris Biomarkers in peritoneal mesothelioma Others: Krishna Pillai, Mohammad Pourgholami Principal investigators: David Morris Determination of pharmacological properties of MPL Others: Farnaz Bahrami, Mohammad Pourgholami Principal investigators: David Morris Unlocking the anticancer properties of MPLSO2 Others: Hieng Lu, Samina Badar, Mohammad Pourgholami Principal investigators: David Morris, Martina Stenzel Preparation and pharmacological evaluation of albendazole albumin Others: Lubna Hossein, Mohammad Pourgholami Principal investigators: David Morris Determination of the role of HSP-1 in breast cancer growth and metastases Others: Ahmed Mekkway, Samina Badar, Mohammad Pourgholami Principal investigators: David Morris Others: Samar Masumi Moghadam, HSPs 1,2, and 4 in ovarian cancer: Expression and biological function Afshin Amini, Samina Badar, Mohammad Pourgholami Principal investigators: Javed Akhter A novel mucolytic formulation to solubilize mucin derived from mucin Co-investigators: David Morris, producing cancers Krishna Pillai, Terence Chua

ORIGINAL PEER-REVIEWED PUBLICATIONS - 2010

Chua TC, Liauw W, Robertson G, Morris DL. Second-line treatment of ﬁrst relapse recurrent ovarian cancer. ANZ Journal of Obstetrics and Gynaecology, 2010. 50(5): 465-471.

Chua TC, Liauw W, Saxena A, Chu F, Glenn D, Chai A, Morris DL. Systematic review of neoadjuvant transarterial chemoembolization for resectable hepatocellular carcinoma. Liver International, 2010. 30(2):166-174.

Chua TC, Saxena A, Liauw W, Kokandi A, Morris DL. Systematic review of randomized and nonrandomized trials of the clinical response and outcomes of neoadjuvant systemic chemotherapy for resectable colorectal liver metastases. Ann Surg Oncol, 2010. 17(2): 492-501.

104 Cao C, Yan TD, Bester L, Liauw W, Morris DL. Radioembolization with yttrium micropheres for neuroendocrine tumour liver metastases. Br J Surg, 2010. 97(4): 537-543.

Cao C, Yan TD, Morris DL, Bester L. Radioembolization with yttrium-90 microspheres for pancreatic cancer liver metastases: Results from a pilot study. Tumori, 2010. 96(6): 955-958.

Chua TC, Al-Zahrani, Saxena A, Liauw W, Zhao J, Morris DL. Secondary cytoreduction and perioperative intraperitoneal chemotherapy after initial debulking of pseudomyxoma peritonei: A study of timing and the impact of malignant dedifferentiation. J Am Coll Surg, 2010. 211(4): 526-535.

Chua TC, Baker B, Yan TD, Zhao J, Morris DL. Palliative effects of an incomplete cytoreduction combined with perioperative intraperitoneal chemotherapy. Am J Clin Oncol, 2010. 33(6): 568-571.

Chua TC, Bester L, Akhter J, Morris DL. Successful right hepatectomy after four treatments of yttrium-90 microspheres (SIR-Spheres (R)) and concomitant FOLFOX as bridging therapy to resection of colorectal liver metastases. Anticancer Res, 2010. 30(7): 3005-3008.

Chua TC, Chu F, Butler P, Quinn RJ, Glenn D, Liauw W, Morris DL. I ntra-arterial iodine-131-lipiodol for unresectable hepatocellular carcinoma. Cancer, 2010. 116(17): 4069-4077.

Chua TC, Glenn D, Morris DL. Extending the survival of patients with melanoma lung metastases through radiofrequency ablation. Acta Oncologica, 2010. 49(4): 517-519.

Chua TC, Martin S, Saxena A, Liauw W, Yan TD, Zhao J, Lok I, Morris DL. Evaluation of the cost-effectiveness of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (Peritonectomy) at the St George Hospital Peritoneal Surface Malignancy Program. Ann Surg, 2010. 251(2): 323-329.

Chua TC, Morris DL, Esquivel J. Impact of the peritoneal surface disease severity score on survival in patients with colorectal cancer peritoneal carcinomatosis undergoing complete cytoreduction and hyperthermic intraperitoneal chemotherapy. Ann Surg Oncol, 2010. 17(5): 1330-1336.

105 Chua TC, Robertson G, Liauw W, Morris DL. Salvage cytoreduction for chemorefractory ovarian cancer with peritoneal carcinomatosis: A last chance or futile efforts? Australian and New Zealand Journal of Obstetrics and Gynaecology, 2010. 50(5): 478-484.

Chua TC, Sarkar A, Saxena A, Glenn D, Zhao J, Morris DL. Long-term outcome of image-guided percutaneous radiofrequency ablation of lung metastases: An open-labelled prospective trial of 148 patients. Ann Oncol, 2010. 21(10): 2017-2022.

Chua TC, Saxena A, Chu F, Liauw W, Zhao J, Morris DL. Clinicopathological determinants of survival after hepatic resection of hepatocellular carcinoma in 97 patients - Experience from an Australian Hepatobiliary Unit. J Gastrointest Surg, 2010. 14(9): 1370-1380.

Chua TC, Saxena A, Morris DL. Surgical metastasectomy in AJCC stage IV M1c melanoma patients with gastrointestinal and liver metastases. Annals of the Academy of Medicine, Singapore, 2010. 39(8): 634-639.

Chua TC, Saxena A, Schellekens JF, Liauw W, Yan TD, Fransi S, Zhao J, Morris DL. Morbidity and mortality outcomes of cytoreductive surgery and perioperative intraperitoneal chemotherapy at a single tertiary institution: Towards a new perspective of this treatment. Ann Surg, 2010. 251(1): 101-106.

Chua TC, Thornbury K, Saxena A, Liauw W, Glenn D, Zhao J, Morris DL. Radiofrequency ablation as an adjunct to systemic chemotherapy for colorectal pulmonary metastases. Cancer, 2010. 116(9): 2106-2114.

Chua TC, Yao P, Akhter J, Morris DL. Impact of tumor angiogenesis in peritoneal mesothelioma after radical cytoreduction and hyperthermic intraperitoneal chemotherapy. Pathology & Oncology Res, 2010. 16(2): 217-222.

Ding JH, Chua TC, Al-Mohaimeed K, Morris DL. Hepatocellular carcinoma peritoneal metastases: Report of three cases and collective review of the literature. Case Report. Annals of the Academy of Medicine, Singapore, 2010. 39(9): 734-737.

Esquivel J., et al., Accuracy and clinical relevance of computed tomography scan interpretation of peritoneal cancer index in colorectal cancer peritoneal carcinomatosis: A multi-institutional study. Ann Surg Oncol, 2010. 102(6): 565-570.

106 Evans KA, Richardson MG, Pavlakis N, Morris DL, Liauw W, Bester L. Survival outcomes of a salvage patient population after radioembolization of hepatic metastases with yttrium-90 microspheres. J Vasc Interv Radiol (JVIR), 2010. 21(10): 1521-1526.

Mekkawy AH, De Bock CE, Lin Z, Morris DL, Wang Y, Pourgholami MH. Novel protein interactors of urokinase-type plasminogen activator receptor. Biochemical and Biophysical Research Communications (BBRC), 2010. 399(4): 738-743.

Morris DL, Chua TC. Treatments and outcomes of peritoneal surface tumors through a Centralized National Service (United Kingdom). Dis Colon Rectum, 2010. 53(8): 1218-1219.

Pourgholami MH, Cai ZY, Chu SWL, Galettis P, Morris DL. The inﬂuence of ovarian cancer induced peritoneal carcinomatosis on the pharmacokinetics of albendazole in nude mice. Anticancer Res, 2010. 30(2): 423-428.

Pourgholami MH, Khachigian LM, Fahmy RG, Badar S, Wang L, Chu SWL, Morris DL. Albendazole inhibits endothelial cell migration, tube formation, vasopermeability, VEGF receptor-2 expression and suppresses retinal neovascularization in ROP model of angiogenesis. Biochemical and Biophysical Research Communications (BBRC), 2010. 397(4): 729-734.

Pourgholami MH, Szwajcer M, Chin M, Liauw W, Seef J, Galettis P, Morris DL. Phase I clinical trial to determine maximum tolerated dose of oral albendazole in patients with advanced cancer. Cancer Chemother Pharmacol, 2010. 65(3): 597-605.

Saxena A, Bester L, Chua TC, Chu F, Morris DL. Yttrium-90 radiotherapy for unresectable intrahepatic cholangiocarcinoma: A preliminary assessment of this novel treatment option. Ann Surg Oncol, 2010. 17(2): 484-491.

Saxena S, Chua TC, Bester L, Kokandi A, Morris DL. Factors predicting response and survival after Yttrium-90 radioembolization of unresectable neuroendocrine tumor liver metastases: A critical appraisal of 48 cases. Ann Surg 2010. 251(5): 910-916.

Saxena A, Chua TC, Sarkar A, Chu F, Morris DL. Clinicopathologic and treatment-related factors inﬂuencing recurrence and survival after hepatic reseciton of intrahepatic cholangiocarcinoma: A 19-year experience from an Established Australian Hepatobiliary Unit. J Gastrointest Surg, 2010. 14(7): 1128-1138.

107 Saxena A, Chua TC, Yan TD, Morris DL. Postoperative pancreatic ﬁstula after cytoreductive surgery and perioperative intraperitoneal chemotherapy: Incidence, risk factors, management, and clinical sequelae. Ann Surg Oncol, 2010. 17(5): 1302-1310.

Saxena A, Yan TD, Chua TC, Morris DL. Critical assessment of risk factors for complications after cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei. Ann Surg Oncol, 2010. 17(5): 1291-1301.

Saxena A, Yan TD, Morris DL. Critical assessment of preoperative and operative risk factors for complications after iterative peritonectomy procedures. Eur J Surg Oncol (EJSO), 2010. 36(3): 309-314.

Saxena A, Yan TD, Morris DL. A critical evaluation of risk factors for complications after cytoreductive surgery and perioperative intraperitoneal chemotherapy for colorectal peritoneal carcinomatosis. World J Surg, 2010. 34(1): 70-78.

Tudor ECG, Chua TC, Liauw W, Morris DL. Risk factors and clinicopathological study of prognostic factors in the peritoneal mesothelioma. American Surgeon, 2010. 76(4): 400-405.

Yao P, Stanton R, Chua TC, Wines M, Gunasegaram A, Ladd LA, Morris DL. Hand-assisted laparoscopic partial nephrectomy: A controlled study of bipolar Inline radiofrequency ablation device in swine. Surgical Innovation, 2010. 17(1): 57-62.

Zhao Y, Pourgholami MH, Morris DL, Collins JG, Day AI. Enhanced cytotoxicity of benzimidazole carbamate derivatives and solubilisation by encapsulation in cucurbit[n]uril. Organic & Biomolecular Chemistry, 2010. 8(14): 3328-3337.

108 ORIGINAL PEER-REVIEWED PUBLICATIONS - 2011

Chua TC, Al-Zahrani A, Saxena A, Glenn D, Liauw W, Zhao J, Morris DL. Determining the association between preoperative computed tomography ﬁndings and postoperative outcomes after cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei. Ann Surg Oncol, 2011. 18(6): 1582-1589.

Chua TC, Al-Alem I, Saxena A, Liauw W, Morris DL. Surgical cytoreduction and survival in appendiceal cancer peritoneal carcinomatosis: An evaluation of 46 consecutive patients. Ann Surg Oncol, 2011. 18(6): p. 1540-1546.

Chua TC, Bester L, Saxena A, Morris DL. Radioembolization and systemic chemotherapy improves response and survival for unresectable colorectal liver metastases. J Cancer Res Clin Oncol, 2011. 137(5): 865-873.

Chua TC, Chu F, Morris DL. Outcomes of single- centre experience of hepatic resection and cryoablation of sarcoma liver metastases. Am J Clin Oncol, 2011. 34(3): 317-320.

Chua TC, Crowe PJ, Morris DL. Whither surgical oncology? (Perspectives). ANZ J Surg, 2011. 81(11): 763-764.

Chua TC, Crowe PJ, Morris DL. Trends in surgical oncology research in Australia during the period 1998-2009 - A bibliometric review. J Surg Oncol, 2011. 104(2): 216-219.

Chua TC, Liauw W, Saxena A, Al-Mohaimeed K, Fransi S, Zhao J, Morris DL. Evolution of locoregional treatment for peritoneal carcinomatosis: Single-centre experience of 308 procedures of cytoreductive surgery and perioperative intraperitoneal chemotherapy. Am J Surg, 2011. 201(2): 149-156.

Chua TC, Liauw W, Zhao J, Morris DL. Upfront compared to delayed cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei is associated with considerably lower perioperative morbidity and recurrence rate. Ann Surg, 2011. 253(4): 769-773.

Chua TC, Morris DL. Reply to radiofrequency ablation as an adjunct to systemic chemotherapy for colorectal pulmonary metastases. Reply to Takao et al. Cancer, 2011. 117(4): 876-877.

109 Chua TC, Morris DL, Saxena A, Esquivel J, Liauw W, Doerfer J, Germer CT, Kerscher AG, Pelz JO. Inﬂuence of modern systemic therapies as adjunct to cytoreduction and perioperative intraperitoneal chemotherapy for patients with colorectal peritoneal carcinomatosis: A Multicenter Study. Ann Surg Oncol, 2011. 18(6): 1560-1567.

Chua TC, Saxena A, Chu F, Butler SP, Quinn RJ, Glenn D, Morris DL. Hepatic resection with or without adjuvant iodine-131-lipiodol for hepatocellular carcinoma: A comparative analysis. Int J Clin Oncol, 2011. 16(2): 125-132.

Chua TC, Saxena A, Chu F, Zhao J, Morris DL. Predictors of cure after hepatic resection of colorectal liver metastases: An analysis of actual 5- and 10- year survivors. J Surg Oncol, 2011. 103(8): 796-800.

Chua TC, Saxena A, Liauw W, Chu F, Morris DL. Hepatic resection for metastatic breast cancer: A systematic review. Eur J Cancer, 2011. 47(15): 2282-2290.

Chua TC, Yan TD, Deraco M, Glehen O, Moran BJ, Sugarbaker PH; Peritoneal Surface Oncology Group. Multi-institutional experience of diffuse intra-abdominal multicystic peritoneal mesothelioma. Br J Surg, 2011. 98(1): 60-64.

Kim Y, Pourgholami MH, Morris DL, Stenzel MH. An optimized RGD-decorated micellar drug delivery system for albendazole for the treatment of ovarian cancer: From RAFT polymer synthesis to cellular uptake. Macromol Biosci, 2011. 11(2): 219-233.

Kim Y, Pourgholami MH, Morris DL, Stenzel MH. Triggering the fast release of drugs from crosslinked micelles in an acidic environment. J Mater Chem, 2011. 21(34): 12777-12783.

Latif E, Chua TC, Morris DL. Damage control surgery for liver rupture following selective internal radiation therapy for unresectable colorectal liver metastases. ANZ J Surg, 2011. 81(7-8): 570-572.

Morris DL, Chua TC, Reply - Refers to: Is malignant dedifferentiation for mucinous appendiceal neoplasms a valid phenomenon or merely histopathologic ambiguity? J Am Coll Surg, 2011. 212(5): 907-907.

110 Pillai K, Akhter J, Pourgholami MH, Morris DL. Peritoneal mesothelioma in a woman who has survived for seven years : A Case Report. J Med Case Reports, 2011. 5:36: 1-4.

Saxena A, Chua TC, Chu FC, Morris DL. Improved outcomes after aggressive surgical resection of hilar cholangiocarcinoma: A critical analysis of recurrence and survival. Am J Surg, 2011. 202(3): 310-320.

Saxena A, Chua TC, Morris DL. In Reply: Pseudomyxoma peritonei: Debulk or maximal cytoreduction? (Letter to the Editor). Ann Surg Oncol, 2011. 18(1): 284-285.

Saxena A, Chua TC, Morris DL. Surgical management and emerging therapies to prolong survival in metastatic neuroendocrine cancer. Ann Surg Oncol, 2011. 18(Suppl 3): S222-S223.

Saxena A, Chua TC, Sarkar A, Chu F, Liauw W, Zhao J, Morris DL. Progression and survival results after radical hepatic metastasectomy of indolent advanced neuroendocrine neoplams (NENs) supports an aggressive surgical approach. Surgery, 2011. 149(2): 209-220.

Yan TD, Deraco M, Elias D, Glehen O, Levine EA, Moran BJ, Morris DL, Chua TC, Piso P, Sugarbaker PH; Peritoneal Surface Oncology Group. A novel Tumor-Node-Metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi-institutional database. Cancer, 2011. 117(9): 1855-1863.

Wang L, Chen H, Pourgholami MH, Beretov J, Hao J, Chao H, Perkins AC, Kearsley JH, Li Y. Anti-MUC1 monoclonal antibody (C595) and docetaxel markedly reduce tumor burden and ascites, and prolong survival in an in vivo ovarian cancer model. PLoS One. 2011;6(9):e24405.

Wang L, Chen H, Liu F, Madigan MC, Power CA, Hao J, Patterson KI, Pourgholami MH, O’Brien PM, Perkins AC, Li Y. Monoclonal antibody targeting MUC1 and increasing sensitivity to docetaxel as a novel strategy in treating human epithelial ovarian cancer. Cancer Letters, 2011 28;300(2):122-33.

111 OTHER PUBLISHED MATERIAL (Books, Book Chapters, Reviews)

Book: Malignant liver tumors: Current and emerging therapies – 3rd edition – Editor: P.A. Clavien – Chapter: Cryoablation of liver tumors – Chapter No: 20. Pages 227-243. Gananadha S, Morris DL. 2010

Book: Induction Chemotherapy – Chapter 4: Cryotherapy. Habib MR, Morris DL 2011. Pages: 43-49. ISBN: 978-364-218-172-6. Editors Karl Reinhard Aigner, Frederick O. Stephens. Publisher: Springer- Verlag Berlin and Heidelberg GmbH & Co. KG

Book: Induction Chemotherapy – Chapter 5: Local and Regional Hyperthermia. Habib MR, Morris DL 2011. Pages: 51-58. ISBN: 978-364-218-172-6. Editors Karl Reinhard Aigner, Frederick O. Stephens. Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Book: Induction Chemotherapy – Chapter 23: Liver Metastases. Habib MR, Morris DL 2011. Pages: 311-319. ISBN: 978-364-218-172-6. Editors Karl Reinhard Aigner, Frederick O. Stephens. Publisher: Springer-Verlag Berlin and Heidelberg GmbH & Co. KG

Book: Advanced Laparoscopy – Chapter 11: Port-site metastasis following laparoscopic surgery. Chua TC, Yan TD, Morris DL, Sugarbaker PH. Pages: 1-12. ISBN: 978-953-307-674-4. Edited by Ali Shamsa. Publisher: InTech, October 2011

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

63rd Annual Cancer Symposium, Society of Surgical Oncology, March 3-7, 2010, St Louis, Missouri

Poster Presentations: Chua TC, Martin S, Saxena A, Liauw W, Yan TD, Zhao J, Lok I, Morris DL. Evaluation of the cost- effectiveness of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (Peritonectomy) at the St George Hospital Peritoneal Surface Malignancy Program Chua TC, Thornbury K, Saxena A, Liauw W, Glenn D, Zhao J, Morris DL. Radifrequency ablation as an adjunct to systemic chemotherapy for colorectal pulmonary metastases. Chua TC, Saxena A, Chu F, Liauw W, Kokandi A, Zhao J, Morris DL. Clinicopathological determinants of survival after hepatic resection of hepatocellular carcinoma in 97 patients – Experience from an Australian Hepatobiliary Unit. Saxena A, Morris DL , Chua TC, Bester L. Factors predicting response and survival after yttrium-90 radioembolization of unresectable neuroendocrine tumor liver metastases: A critical appraisal of 48 cases. Saxena A, Bester L, Chua TC, Morris DL. Yttrium-90 radiotherapy for unresectable intrahepatic cholangiocarcinoma: A preliminary assessment of this novel treatment option.

112 Oral Presentation: Chua TC, Chu F, Butler SP, Quinn RJ, Glenn D, Morris DL. Intra-arterial iodine-131-lipiodol for unresectable hepatocellular carcinoma.

AACR 101st Annual Meeting 2010, April 17-21, Walter E. Washington Convention Centre, Washington, DC.

Poster Presentation: Pourgholami MH, Cai ZY, Badar S, Poruchynsky M, Morris DL. Down-regulation of tumoral hypoxia- inducible factor-1alpha expression in OVCAR-3 tumors by albendazole. (Poster Board No: 20, Location: Exhibit Hall A-C, Poster Section 13).

7th International Workshop on Peritoneal Surface Malignancy, Uppsala, Sweden. September 8-10, 2010.

Case Presentation and Consultants Panel: Experts Panel: Morris DL

Oral Presentations: Morris DL. Management of high grade PMP. Chua TC. Synchronous thorax and abdomen PMP: Thorax or abdomen ﬁrst?

Poster Presentations: Pelz JOW, Chua TC, Esquivel J, Stojadinovic A, Doerfer J, Morris DL, Germer CT, Kerscher AG. Evaluation of best supportive care and systemic chemotherapy as treatment for peritoneal carcinomatosis of colorectal origin. (Abstract No: P17), Page 65.

Chua TC, Morris DL, Saxena A, Esquivel J, Liauw W, Doerfer J, Germer CT, Kerscher AG, Pelz JO. Inﬂuence of modern systemic therapies and its potential for cure from colorectal peritoneal carcinomatosis treated by cytoreductive surgery combined with perioperative intraperitoneal chemotherapy: A multicentre study. (Abstract No: P76), Page 127.

3rd International Surgical Conference “Surgical Oncology Updates” 13-15 December 2010, King Fahad Specialist Hospital Dammam

Chairman: Professor David Morris. Morris DL. SIRT in metastaitic Neuroendocrine Tumors. Morris DL. Peritonectomy: Indications, Complications and Results. Morris DL. Resection and ablation for colorectal liver metastases.

113 3rd International Surgical Conference “Surgical Oncology Updates” 13-15 December 2010, King Fahad Specialist Hospital Dammam.

Al Nahawi M. Peritonectomy: How we do it in Sydney.

International Conference “Cell Cycle Regulators/Inhibitors & Cancer” (CCRIC), Vienna, Austria, February 5-8, 2011

Oral Presentation: Pourgholami MH. Albendazole down-regulated anti-apoptotic proteins and arrests cell cycle progression in peritoneal mesothelioma cells

Annual Cancer Symposium Society of Surgical Oncology, 3rd – 7th March 2011, San Antonio, Texas, USA

Poster Presentations: Chua TC, Al-Zahrani A, Saxena A, Glenn D, Liauw W, Zhao J, Morris DL. Determining the association between preoperative computed tomography ﬁndings and post-operative outcomes after cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei Saxena A, Chua TC, Morris DL. Liver-Directed therapy as treatment of hepatic progression following surgical extirpaton of neuroendocrine neoplasm hepatic metastasis Saxena A, Chua TC, Zhao J, Morris DL. Optimizing the surgical effort in patients with advanced neuroendocrine tumor hepatic metastases by combining hepatic resection with ablation: A critical analysis of 40 patients

International Surgical Congress of the Association of Surgeons of Great Britain and Ireland (ASGBI). Bournemouth, UK, 11-13 May 2011

Poster Presentations: Kirby RE, Zhao J, Liauw W, Morris DL. A cost analysis: Cytoreductive surgery and heated intraperitoneal chemotherapy versus heated intraperitoneal chemotherapy and early postoperative intraperitoneal chemotherapy Kirby RE, Zhao J, Liauw W, Morris DL. Quality of life study post cytoreductive surgery and intraperitoneal chemotherapy for pseudomyxoma peritoneii.

European-Society-for-Medical-Oncology (ESMO) 13th World Congress on Gastrointestinal Cancer. Barcelona, Spain. 22-25 June 2011

Poster Presentation: Chua TC, Zhao J, Glenn D, Liauw W, Morris DL. Radiofrequency ablation of concomitant and recurrent pulmonary metastases after surgery for colorectal liver metastases

114 5th International Symposium on Abdominal Metastatic Cancer, Regensburg, Germany 4th-5th July, 2011

Oral Presentations: Saxena A, Chua TC, Morris DL. A systematic review of hepatic resection for neuroendocrine neoplasm hepatic metastases Chua TC, Saxena A, Liauw W, Chu F, Morris DL. Hepatectomy and resection of concomitant extrahepatic disease for colorectal liver metastases

5th International Symposium on Abdominal Metastatic Cancer, Regensburg, Germany 4th-5th July, 2011

Session 1: Morris DL. Selection criteria for surgical treatment of liver metastases Morris DL. Combination of liver resection with regional chemotherapy and/or radiofrequency ablation

Session 4: Sugarbaker PH, Morris DL, Piso P, Esquivel J. Case Presentations

Session 5: Morris DL. How to start a PC Program

ESSO Advanced Course “Management of Peritoneal Surface Malignancy” 27-29 November 2011, Bergamo, Italy

Morris DL Co-Chairing with Deraco M

115 National

Annual Scientiﬁc Congress, Perth Convention Exhibition Centre, Perth, Australia 4-7 May 2010

Poster Presentation: Saxena A, Morris DL. Clinicopathologic and treatment-related factors inﬂuencing recurrence and survival after hepatic resection of intrahepatic cholangiocarcinoma: A 19-year experience form an Established Australian Hepatobiliary.

Oral Presentations Morris DL. Progression and survival results following radical hepatic metastasectomy of advanced neuroendocrine tumor supports an aggressive surgical approach. (Winner of Astra Zeneca Surgical Trainee Research Prize) Morris DL. Evaluation of the effectiveness of a novel anaesthetic protocol in reducing massive blood transfusion during cytoreductive surgery: Can early and aggressive administration of fresh frozen plasma combined with restrictive ﬂuid resuscitation really work?

Clinical Oncological Society of Australia (COSA) Annual Scientiﬁc Meeting. 9th-11th November 2010, Melbourne, Australia.

Oral Presentation: Chua TC, Liauw W, Zhao J, Morris DL. Upfront compared to delayed cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei is associated with considerably lower perioperative morbidity and recurrence rate.

Poster Presentation: Chua TC, Ihssan A, Saxena A, Sarkar A, Liauw W, Morris DL. Surgical cytoreduction and survival in appendiceal cancer peritoneal carcinomatosis: An evaluation of 46 consecutively treated patients.

Royal Australasian College of Surgeons, 80th Annual Scientiﬁc Congress, Adelaide Convention Centre, SA, 2-6 May 2011

Oral Presentation: Chua TC, Crowe PJ, Morris DL. A bibliometric review of trends in surgical oncology research in Australia during the period 1998 to 2009 Morris DL. How surgeons can inﬂuence government decision – making

Poster Presentations: Koh JL, Lim C, Chua TC, Cohen-Hallaleh R, Liauw W, Morris DL. Prognostic value of serum tumor marker CA125 in malignant peritoneal mesothelioma (MPM) Ng KM, Chua TC, Saxena A, Zhao J, Chu F, Morris DL. Two decades of experience with hepatic cryotherapy for advanced colorectal liver metastases

116 NSW Neuroendocrine Tumour Masterclass. Saturday 10 September 2011, Novartis Head Ofﬁce, 54 Waterloo Road, North Ryde

Morris DL. PRRT/Interventional radiology (SIRT/TACE) Morris DL. Surgery and management of liver metastases Morris DL, Lam V. Surgery and management of liver metastases Morris DL. Diagnostic imaging and staging for PRRT

23rd Lorne Cancer Conference Melbourne 2011

Poster Presentation: Ataie P, Morris DL, Pourgholami MH. Potent inhibition of interleukin-6 expression and receptor system by minocycline in ovarian cancer

St. George Symposium 2011

Poster Presentations: Ataie P, Badar S, Morris DL, Pourgholami MH. Minocycline inhibits IL-6, IL-6 receptor and VEGF expression associated with inhibition of STAT-3 and PI3K/AKT pathway activation in an ovarian carcinoma model

Bahrami F, Pourgholami MH, Morris DL. Effect of minocycline on ATP levels In ovarian cancer cells Hossain L, Pourgholami MH, Stenzel M, Morris DL. Albendazole Suppresses Proliferation and Induces Apoptosis in Human Hormone Resistant Prostate Cancer Cells PC-3 & DU-145

Pillia K, Pourgholami MH, Chua TC, Morris DL. : Estrogen receptors are prognostic factors in malignant peritoneal mesothelioma

Amini A, Farjoo MH, Javadi Paydar M, Badar S, Morris DL, Pourgholami MH. Mebendazole, but not thiabendazole, is a potent inhibitor of malignant ascites formation in a nude mice xenograft model of ovarian cancer with peritoneal carcinomatosis

COMMUNITY ENGAGEMENT

None reported.

117 SURGERY DEPARTMENT OF COLORECTAL SURGERY

DEPARTMENTAL STAFF*

Head of Department Assc Prof David Lubowski FRACS

Research Staff Vicki Patton RN BaHealth MN(Hons)

RESEARCH GRANTS

Bupa Foundation grant 2011 $71000

118 RESEARCH PROJECTS IN PROGRESS

Title Investigators

Dr Emmanuel Karantanis (Urogynaecology, Staff Specialist O & G) Predictive factors for anal incontinence in women who experience obstetric anal Assc Prof David Lubowski Director sphincter injury. Colorectal Surgery / Anorectal Physiology Project Outline: Prospective study examining women who have obstetric anal Vicki Patton CNC Anorectal Physiology sphincter injury after vaginal delivery . Dr Kate Gardiner O & G Registrar Katrina Parkin RN RM Research Pelvic Floor Unit Dr Sapna Dilgir O & G Registrar Katrina Parkin RN RM Research Pelvic Floor Unit Women who experience obstetric anal sphincter injury vs controls. A prospective Dr Kate Gardiner O & G Registrar comparison of antenatal and intrapartum intra partum risk factors. Vicki Patton CNC Anorectal Physiology Project Outline: Prospective study comparing women who sustain third degree Assc Prof David Lubowski Director tear with controls. Colorectal Surgery / Anorectal Physiology Dr Emmanuel Karantanis (Urogynaecology, Staff Specialist O & G) Vicki Patton CNC Anorectal Physiology Patients with constipation and faecal incontinence. Assc Prof. Denis King Colorectal Surgeon Project Outline: Prospective observational study to examine the characteristics of Dr Phillip Dinning Research Fellow patients with dual symptoms of constipation and incontinence. Gastroenterology Long term followup of patients with cutting seton. Assc Prof David Lubowski Director Project Outline: Followup of patient who have had cutting seton for complex Colorectal Surgery / Anorectal Physiology anal ﬁstula, examining clinical outcome, continence scores, quality of life and Vicki Patton CNC Anorectal Physiology satisfaction with procedure. Chung Min Cheng Colorectal Fellow Clinical outcomes of patients who have had insertion of sacral nerve stimulation for treatment of faecal incontinence. Vicki Patton CNC Anorectal Physiology Project Outline: Followup of patients who have had insertion of sacral nerve Dr Nicholas Lutton Colorectal Fellow stimulator examining clinical outcome, continence scores, quality of life and Dr Earl Abraham Colorectal Resident satisfaction with procedure. Follow up of patients who have had insertion of Chait Cecostomy Catheter for administration of antegrade colonic enemas for bowel management. Vicki Patton CNC Anorectal Physiology Project Outline: Follow up of patients who have had insertion of Chait Cecostomy Assc Prof David Lubowski Director Catheter for bowel management . The study examines clinical outcome, patient Colorectal Surgery / Anorectal Physiology practises with irrigation technique, quality of life and satisfaction with procedure. Vicki Patton CNC Anorectal Physiology The effect of sacral nerve stimulation on colonic movement in patients with Dr John Arkwright CSIRO Fibre Optic neurogenic faecal incontinence. Dr Phillip Dinning Research Fellow Project Outline: To study the impact of sacral nerve stimulation on colonic wave Gastroenterology patterns in people with faecal incontinence using high resolution ﬁbre optic Prof Denis King Colorectal Surgeon manometry catheter in patients with faecal incontinence and constipation Prof. Ian Cook Gastroenterology Katrina Parkin RN RM Pelvic Floor Unit Research Nurse The “bottom up” cost of faecal incontinence. Vicki Patton CNC Anorectal Physiology Project outline: A prospective study into the direct and personal costs of faecal Assc Prof David Lubowski Director incontinence in community dwelling men and women. Colorectal Surgery / Anorectal Physiology Prof Kate Moore Director Bladder Unit , Dept Urogynaecology St George Vicki Patton CNC Anorectal physiology Vitamin A for radiation proctitis. Pam Williams RN Research Nurse Project outline: A double blinded RCT oral vitamin A supplementation for the Dr Phillip Dinning Research Fellow treatment of radiation proctitis. Gastroenterology Prof Denis King Colorectal surgery Dr Natalie McFadden Colorectal Surgeon Research fellow Sexual function and quality of life after rectal resection. Prof Graham Newstead Prof Colorectal Project Outline: A retrospective review and prospective measures of quality of life Suregery POWH and sexual function in patients following rectal resection for cancer. Assc Prof David Lubowski Director Colorectal Surgery / Anorectal Physiology

119 ORIGINAL PEER-REVIEWED PUBLICATIONS

None reported

OTHER PUBLISHED MATERIAL (Books, Book Chapters, Reviews) (Not To Include Conf Abstracts)

None reported

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International conferences

Digestive Diseases week Chicago USA May 2011. Podium presentation Sacral nerve stimulation alters the frequency of colon propogating sequences in patients with neurogenic faecal incontinence. Vicki Patton, Dr John Arkwright, Prof Denis King, Dr Phillip Dinning, David Lubowski

Tripartite Colorectal Conference Cairns July 2011 . Podium presentation Patients with neurogenic faecal incontinence show an alteration in colonic motility following sacral nerve stimulation. Vicki Patton, Dr John Arkwright, Prof Denis King, Dr Phillip Dinning, David Lubowski

International Continence Society Glasgow Aug 2011 Poster: The “bottom up” cost of faecal incontinence. Katrina Parkin, Vicki Patton, David Lubowski, Kate Moore

National conferences

Australian Council Midwives (NSW Branch) August 26th 2011 , Sydney Anorectal assessment of perineal tears. Is LSCS the answer for subsequent deliveries? Podium presentation. Vicki Patton, Katrina Parkin, David Lubowski, Emmanuel Karantanis

Continence Foundation Of Australia Conference November 2011 Melbourne. Podium Presentation The “bottom up” cost of faecal incontinence. Vicki Patton, Katrina Parkin, David Lubowski, Prof Kate Moore

COMMUNITY ENGAGEMENT

None reported

120 SURGERY DEPARTMENT OF NEUROSURGERY ST GEORGE HOSPITAL

DEPARTMENTAL STAFF*

Head of Department Mark Davies MB.BS., FRACS (Conjoint Senior Lecturer UNSW)

Senior Medical Staff

Staff specialists - nil

Visiting Medical Ofﬁcers Bernard Kwok MBChB, FRACS (Conjoint Senior Lecturer UNSW) Warwick Stening MB.BS., FRCS, FRACS Erica Jacobson MB, PhD, FRACS Saeed Kohan MB, BS, FRACS

Junior medical staff Vocational registrars, advanced trainees Ali Ghahreman MB.BS Peter Mews MB.BS.

RESEARCH GRANTS# None reported

RESEARCH PROJECTS IN PROGRESS

Title Investigators

Spine Wave Injectable Disc Nucleus M Davies - Principal Investigator SESAHS HREC. CTN SWP303 04/69

A prospective randomized study comparing the use of Actifuse synthetic bone substitute with Infuse in patients requiring posterolateral instrumented M Davies - Principal Investigator lumbar fusion. UNSW HREC 08060/UoW CT07/001

Assessment of Dynamic Enhanced MRI in Brain tumours M Davies - coinvestigator SESIAHS HREC ref: 08/stg/87

121 ORIGINAL PEER-REVIEWED PUBLICATIONS

None reported

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews) (Not to include conf abstracts)

How to treat Spinal Canal Stenosis and Spondylolisthesis M Davies Australian Doctor. 25 Jun 2010. www.australiandoctor.com

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

“Posterior Cervical Foramenotomy: a part of every surgeons portfolio” M.Davies Asia Paciﬁc Spine Society, Annual Scientiﬁc Meeting, Sydney Nov 2010

National M.Davies. “Why we should be using stereotaxy in Spine surgery” NSA Spine Surgery CPD workshop.April 2010.

M Davies “Posterior approaches, my indications for and management of complications” Neurosurgical Society of Australasia, Annual Scientiﬁc Meeting, Sept 2011

COMMUNITY ENGAGEMENT

None reported.

122 SURGERY DEPARTMENT OF ORTHOPAEDICS

DEPARTMENTAL STAFF*

Head of Department Robert Molnar

Senior Medical Staff Staff specialists Dr Ashish Diwan

Visiting Medical Ofﬁcers Dr Hugh Jones Dr Wayne Viglione Dr Paul Hitchen Dr Zoltan Szomor Dr Robert Molnar Dr Ian Harris Dr S P Tan Dr Michael Dixon Dr Anthony Keeley

Junior Medical Staff Vocational registrars, advanced trainees

Research Staff Senior Research Staff Prof George Murrell (Director – Orthopaedic Research Institute) A/Prof Judie Walton Ai Qun Wei

123 Research Assistants Patrick Lam Research Students 2010 Geffrey Keighley Kaitlyn Hansen Jared Millican Henry Shepherd Liz Tham 2011 Stewart Leason Nicola Hicks John Khoo Brian Le

RESEARCH GRANTS#

Category I - Nationally Competitive Grants:

Australian Orthopaedic Association Research Foundation Rajat Mittal, IA Harris, JM Naylor, S Adie Combined randomized and observational study of surgery for type B ankle fracture treatment (CROSSBAT) $35,337.50 (2010-2011)

124 RESEARCH PROJECTS IN PROGRESS

Title Investigators

Examination of in-hospital deaths in elderly patients with hip fractures. Morellato J, Harris IA, Molnar RB.

Nivbrant B, Smith P, Bruce W, Byrne A, The Journey TKA project: A comparison of two concepts for improved function of Gallie P, Paterson R, Mercer G, Molnar RB, knee replacements. Campbell D, Comley A.

Screw home mechanism in cruciate retaining and posterior stabilized total knee Collins DJ, Khatib Y, Parker D, Jenkin DE, arthroplasty. Molnar RB.

Prospective randomised pilot study comparing LCP (Locking Clavicle Plate) ﬁxation with HCS (Headless Compression Screw), for the Treatment of displaced Molnar RB. midshaft clavicle fracture.

Radiostereometric Analysis (RSA), of the Genesis II minimally invasive surgery (MIS) Molnar RB. tibial base plate.

Prospective randomised study comparing the dynamic hip screw and Molnar RB. intramedullary gamma nail for the treatment of intertrochanteric hip fracture.

To validate acetabular cup placement in total hip arthroplasty (THA) using CAS Molnar RB. (computer assisted surgery).

Safe zones for femoral tunnels in multi-ligament knee reconstruction. Molnar RB.

A pilot study to assess a multimodal approach to short stay arthroplasty. Small T, Molnar RB

ORIGINAL PEER-REVIEWED PUBLICATIONS

Sein ML,Walton J,Linklater J,Appleyard R,Kirkbride B,Kuah D,Murrell GA. (2010) Shoulder pain in elite swimmers: primarily due to swim-volume-induced supraspinatus tendinopathy. Br J Sports Med 44 (2) 105-13.

Andres BM,Lam PH,Murrell GAC. (2010) Tension, abduction and surgical technique effect footprint compression following rotator cuff repair in an ovine model. J Shoulder Elbow Surg 19 (7) 1018-27.

Peters KS,Lam PH,Murrell GAC. (2010) Repair of partial-thickness rotator cuff tears: a biomechanical analysis of footprint contact pressure and strength in an ovine model. Arthroscopy 26 (7) 877-44.

Brisby H,Wei A-Q,Molloy T,Chung S,Murrell GAC,Diwan A. (2010) The effect of running exercise on intervertebral disc extracellular matrix production in a rat model. Spine 35 (15) 1429-36.

125 Millar NL,Hueber AJ,Reilly JH,Xu Y,Fazzi UG,Murrell GA,McInnes IB. (2010) Inﬂammation is present in early human tendinopathy. Am J Sports Med 38 (10) 2085-91.

McCallum S,Paoloni J,Murrell GAC. (2011) Five year prospective comparison study of topical glyceryl trinitrate treatment of chronic lateral epicondylosis at the elbow. Br J Sports Med 45 416-20.

Paoloni J,De Vos RJ,Hamilton B,Murrell GA,Orchard J. (2011) Platelet-rich plasma treatment for ligament and tendon injuries. Clin J Sport Med 21 (1) 37-45.

Beshay N,Lam PH,Murrell GAC. (2011) Assessing the reliability of shoulder strength measurement: hand-held versus ﬁxed dynamometry. Shoulder and Elbow 3 244-51.

Xu X,Bonar F,Murrell GAC. (2011) Neoinnervation in rotator cuff tendinopathy. Sports Medicine and Arthroscopy Review 19 (4) 1-6.

Xu Y,Bonar F,Murrell GA. (2011) Enhanced expression of neuronal proteins in idiopathic frozen shoulder. J Shoulder Elbow Surg.

Walton JR,Murrell GAC. (2011) Effect of operative time on outcomes of rotator cuff repair. Tech Shoulder Elbow Surg in press (4-10-11).

Walton JR,Murrell GAC. (2011) Clinical tests diagnostic for rotator cuff tear. Tech Shoulder Elbow Surg in press (4-10-11).

Lam P,Murrell GAC. (2011) Biomechanical considerations for rotator cuff repairs. Tech Shoulder Elbow Surg 12 (4) 108-15.

Bhargav D, Murrell GAC. (2011) Basic science of adhesive capsulitis. Tech Shoulder Elbow Surg 12 (4) 126-9.

Briggs L,Murrell GAC. (2011) Diagnostic ultrasound examination of the shoulder. Tech Shoulder Elbow Surg 12 (4) 101-7.

126 Ronquillo J,Szomor Z,Murrell GAC. (2011) Examination of the shoulder. Tech Shoulder Elbow Surg 12 (4) 116-25.

Shepherd HM,Lam P,Murrell GAC. (2011) Biomechanics of synthetic patch rotator cuff repairs. Tech Shoulder Elbow Surg 12 (4) 94-100.

Adie S, Naylor JM, Harris IA Cryotherapy After Total Knee Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials, Journal of Arthroplasty. 2010 Aug;25(5):709-715

Harris IA, Yong S, McEvoy L, Thorn L . A prospective study of the effect of nursing home residency on mortality following hip fracture. ANZ J Surg. 2010 Jun;80(6):447-50

Christopher J. Wall, Joan Lynch, Ian A. Harris, Martin D. Richardson, Caroline Brand, Adrian J. Lowe and Michael Surgrue. Clinical practice guidelines for the management of acute limb compartment syndrome following trauma. ANZ J Surg. 2010 Mar;80(3):151-6

JM Naylor, S. Adie, M. Fransen, S. Dietsch, Harris IA. Endorsing single-unit transfusion combined with a restrictive haemoglobin transfusion threshold after arthroplasty: a quality improvement report. Qual Saf Health Care 2010;(19):239-243

Stephen A. Deane, Donald G. MacLellan, Gavin L. Meredith and Patrick C. Cregan on behalf of the Surgical Services Taskforce – Emergency Surgery Sub-group. Making sense of emergency surgery in New South Wales: a position statement. ANZ J Surg. 2010 Mar;80(3):119-21

Ian A Harris, Jane M Young, Bin B Jalaludin, Michael J Solomon. Predictors of neck pain after motor vehicle collisions: a prospective survey. Journal of Orthopaedic Surgery 2011;19(3):317-21

Joseph D. Isaacs, Louis Shidiak, Ian A. Harris, Zoltan L. Szomor. Femoral Insufﬁciency Fractures Associated with Prolonged Bisphosphonate Therapy. Clin Orthop Relat Res. 2010 Dec; 468(12):3384-3392

Gabbe B, Harris IA, Cameron P, Collie A . Does access to compensation have an impact on recovery outcomes after injury? (Letter). Med J Aust 2010; 193(3): 188-190

127 Darnel F Murgatroyd, Ian D Cameron, Ian A Harris. Understanding the effect of compensation on recovery from severe motor vehicle crash injuries: a qualitative study. Inj Prev 2011;17:222-227 Published Online First: 11 November 2010 doi:10.1136/ip.2010.029546

Unsari U, Adie S, Harris IA, Naylor JM. Practice variation in common fracture presentations: A survey of orthopaedic surgeons. Injury 2011; 42(4): 403-407

Justine M. Naylor, Rajat Mittal, Katherine Carroll, Ian A. Harris. Introductory insights into patient preferences for outpatient rehabilitation after knee replacement: implications for practice and future research. Journal of Evaluation in Clinical Practice. 2010, doi: 10.1111/j.1365-2753.01619.x

Raewyn Campbell, Grad Dip, M.G. Berry, Anand Deva, Timothy O’Carrigan, Ian A. Harris Aggressive management of tibial osteomyelitis shows good functional outcomes. ePlasty. 2011 Jan25;11:e3

Justine M. Naylor , Victoria Ko, Steve Rougellis, Nick Green, Danella Hackett, Ann Magrath , Anne Barnett, Grace Kim, Megan White, Priya Nathan, Alison Harmer, Martin Mackey, Rob Heard, Anthony E. T. Yeo, Sam Adie, Ian A. Harris, Rajat Mittal, Adam Cho. Is discharge knee range of motion a useful and relevant clinical indicator after total knee replacement? Part 1. Journal of Evaluation in Clinical Practice Article ﬁrst published online: 18 Mar 2011 DOI: 10.1111/j.1365-2753.2011.01655.x

JM. Naylor, Victoria Ko , Steve Rougellis, Nick Green, Rajat Mittal, Rob Heard, Anthony E. T. Yeo , Anne Barnett , Danella Hackett, Chris Saliba, Nicole Smith, Martin Mackey, Alison Harmer, Ian A. Harris, Sam Adie, Lynette McEvoy. Is discharge knee range of motion a useful and relevant clinical indicator after total knee replacement? Part 2. Journal of Evaluation in Clinical Practice Article ﬁrst published online: 18 MAR 2011 DOI: 10.1111/j.1365-2753.2011.01656.x

Sarah So, Ian A Harris, Justine M Naylor, Sam Adie, Rajat Mittal. The correlation between metal allergy and ankle outcomes after ankle fracture ﬁxation. Journal of Orthopaedic Surgery 2011;19(3):309-13

Sam Adie, Ian A. Harris, Justine M. Naylor, Hamish Rae, Alan Dao, Sarah Yong, Victoria Ying. Pulsed Electromagnetic Field Stimulation for Acute Tibial Shaft Fractures: A Multicenter, Double- Blind, Randomized Trial. J Bone Joint Surg Am. 2011; 93(17):1569-1576

128 Wernecke G, Harris IA, Houang MT, Seeto BG, Chen DB, MacDessi SJ. Using magnetic resonance imaging to predict adequate graft diameters for autologous hamstring double-bundle anterior cruciate ligament reconstruction. Arthroscopy. 2011 Aug;27(8):1055-9

Justine M Naylor, Victoria Ko, Sam Adie, Clive Gaskin, Richard Walker, Ian A Harris, Rajat Mittal. Validity and reliability of using photography for measuring knee range of motion: a methodological study. BMC Musculoskeletal 2011, 12:77

Justine Naylor, Rajat Mittal, David Greenﬁeld, Jacqueline Milne, Victoria Ko, Ian A Harris, Sam Adie. Scope for a ‘one size ﬁts all’ rehabilitation approach after knee replacement? Heterogeneity in patient preferences makes this unlikely. The International Journal of Person Centered Medicine 2011; 1(2):254-259

Giza E, Sullivan M, Ocel D, Lundeen G, Mitchell M, Veris L, Walton J. (2010). Matrix induced Autologous Chondrocyte Implantation of Talus Articular Defects: Two Year Prospective Study. Foot Ankle Int. 2010, 31:147-153.123.

Khatib Y, Isaacs JD, Walsh NA, Walton J, Molnar RB (2011). Hip fracture surgery and clopidogrel: Is it safe to operate without delay? J. Orthopaedics, 2011, 8(1)e9.

Walsh MJ, Walsh NA, Walton JR. Surgical Repair of the Gluteal Tendons. A report of 72 cases. J. Arthroplasty, 2011, 26(8) 1514-1519.

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

None reported

129 PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

Millar NL,Hueber A,Reilly J, Xu Y-H, Leach W,Rooney B,Murrell GAC,McInnes I. (2010) The role of Interleukin 17 in human tendinopathy. 56th Annual Meeting of the Orthopaedic Research Society, March 6-9, 2010, New Orleans, Louisiana. Poster 430, New Investigator Recognition Awards (NIRA) Finalist.

Millar NL,Hueber A,Reilly J,Xu Y-H,Fazzi U,Murrell GAC,McInnes I. (2010) The role of inﬂammation in a human model of tendinopathy. 56th Annual Meeting of the Orthopaedic Research Society, March 6-9, 2010, New Orleans, Louisiana. Poster 1114.

Walton JR,Murrell GAC. (2010) Rotator cuff repair outcomes: Arthroscopy vs open surgery, 56th Annual Meeting of the Orthopaedic Research Society, March 6-9, 2010, New Orleans, Louisiana. Poster 1783.

Peters K,Murrell GAC. (2010) Outcomes of arthroscopic repair of partial thickness versus full thickness rotator cuff tears. 56th Annual Meeting of the Orthopaedic Research Society, March 6-9, 2010, New Orleans, Louisiana. Paper 225. March 9, 2010 2:45 PM to 3:00 PM

Peters K,Lam P, Murrell GAC. (2010) Repair of partial thickness rotator cuff tears: a biomechanical analysis of footprint pressure and strength in an ovine model. 56th Annual Meeting of the Orthopaedic Research Society, March 6-9, 2010, New Orleans, Louisiana. Poster 1794.

Xu C,Bonar F,Murrell GAC. (2010) Expression of neuronal markers PGP9.5 & GAP43 in Rotator Cuff Tendinopathy. 77th Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans, LA. Paper No. 324

Peters K, Murrell GAC. (2010) Outcomes of arthroscopic repair of partial thickness versus full thickness rotator cuff tears. 77th Annual Meeting of the American Academy of Orthopaedic Surgeons, New Orleans, LA. Paper No. 281

Millar NL,Hueber, AJ, Murrell GAC, McInnes IB. (2011) Interleukin 17 and tendinopathy :- A critical regulator. ASES Specialty Day, February 2011. Paper.

130 Millar NL,Hueber, AJ, Murrell GAC, McInnes IB. (2011) Inﬂammation is present in early tendinopathy. 78th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Diego, California. Podium 682.

Xu C,Bonar F,Murrell GAC. (2011) Expression of neuronal markers in frozen shoulder. 78th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Diego, California. Poster P301.

Yang Q, Murrell GAC. (2011) Turnover time in arthroscopic shoulder surgery: a reduction of 18% by three simple strategies. 78th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Diego, California. Podium 116.

Kelly M,Lam P,Briggs L,Murrell GAC. (2011) “Ultrasound-Guided Placement of a Localization Wire For Arthroscopic Treatment of Calciﬁc Tendonitis” 78th Annual Meeting of the American Academy of Orthopaedic Surgeons, San Diego, California. Multimedia Multimedia Education Center Featured Presentation 65.

Tham L,Briggs L,Murrell GAC. (2011) Ultrasound changes after rotator cuff repair – is supraspinatus tendon thickness related to pain? European Society for Surgery of the Shoulder and the Elbow (SECEC/ESSSE) congress Lyon 2011. Podium.

Le Lievre HJ, Murrell GAC. (2011) Excellent long-term outcomes of arthroscopic capsular release for frozen shoulder. European Society for Surgery of the Shoulder and the Elbow (SECEC/ESSSE) congress Lyon 2011. Podium.

National

2010

Molnar RB, Alfredson M. To validate acetabular cup placement in total hip arthroplasty (THA) using CAS (computer assisted surgery). The AOA NSW branch meeting, 13th August 2010.

Molnar R, C-Spine in Intubated Patients. Austrauma, February 2010.

131 Shidiak L, Gan JH, Appleyard R, Gillies M, Molnar RB. Angled screws as a method in reducing periprosthetic stress concentration. The AOA NSW branch meeting, 13th August 2010.

Collins DJ, Khatib Y, Parker D, Jenkin DE, Molnar RB. Screw home mechanism in cruciate retaining and posterior stabilized total knee arthroplasty. The AOA ACT branch meeting, November 2010.

Harris, Ian External ﬁxation vs C clamp for pelvic fracture ﬁxation. Read at Austrauma, Sydney, 12-13 February, 2010

Harris, Ian Controversies in hip fracture care, Read at Austrauma, Sydney, 12-13 February, 2010

Harris, Ian Damage control orthopaedics, Read at Austrauma, Sydney, 12-13 February, 2010

Justine Naylor, Victoria Ko, Sam Adie, Ian Harris, Reﬁne your clinical indicators or desist: Part 1, Read at Australian Conference on Safety and Quality in Health Care Conference, Perth, 6-8 September, 2010

Justine Naylor, Victoria Ko, Sam Adie, Ian Harris, Reﬁne you clinical indicators or desist: Part 2, Read at Australian Conference on Safety and Quality in Health Care Conference, Perth, 6-8 September, 2010

Ian Harris, Orthogeriatrics: an orthopaedic surgeon’s perspective, Read at ACI Orthogeriatrics conference, Sydney, 13 August, 2010

Ian Harris History, mechanics and biology of intramedullary nailing, Read at OTC femoral and tibial nailing workshop, Sydney, 21 August, 2010

Ian Harris Subtrochanteric femur fractures: decision making, implant selection, technical tricks, Read at OTC femoral and tibial nailing workshop, Sydney, 21 August, 2010

Justine Naylor, Victoria Ko, Ian Harris et al, The TKR range of motion clinical indicator: is it attained and what predicts discharge range of motion? Read at NSW AOA Annual Scientiﬁc meeting, Sydney, 20 August, 2010

132 Justine Naylor, Victoria Ko, Ian Harris et al, The TKR range of motion clinical indicator: does discharge range of motion matter? Read at NSW AOA Annual Scientiﬁc meeting Sydney, 20 August, 2010

Ian Harris 10 tips on how to do good research, Read at NSW AOA Annual Scientiﬁc meeting, Sydney, 20 August, 2010

Greg Wernecke, Sam Macdessi, Ian Harris, Michael Houang, Bradley Seeto, Darren Chen, Using MRI to predict adequate graft diameters for autologous hamstring double bundle anterior cruciate ligament reconstruction, Read at NSW AOA Annual Scientiﬁc meeting, Sydney, 20 August, 2010, Read at AOA Annual Scientiﬁc Meeting, Adelaide, 9-14 October, 2010

Ian Harris, The wide gap between bench and bedside: failures in translating research into practice, Read at TERMIS (tissue engineering and regenerative medicine international society) Asia-Paciﬁc conference. Sydney, 16 September, 2010

Ian Harris, The effect of compensation on recovery, Read at Personal Injury Management Conference, Melbourne, 13-15 October, 2010

Greg Wernecke, Sam Macdessi, Ian Harris, Michael Houang, Bradley Seeto, Darren Chen, A comparison of tibial bone coverage amongst six modern total knee arthroplasties: An MRI Analysis with optimal component rotation, Poster presentation at AOA Annual Scientiﬁc Meeting, Adelaide, 9-14 October, 2010, Read at NSW AOA ASM, Sydney, 19 August, 2011

Ian Harris, The rise and rise of lumbar fusion in Australia, AOA Continuing Orthopaedic Education: Spine, Melbourne, 14-15 April, 2011

Ian Harris, Surgery as placebo, Hamilton Russell Memorial Lecture, RACS 80th Annual Scientiﬁc Congress, Adelaide, 2-6 May, 2011 Read at NSW AOA ASM, Sydney, 19 August, 2011, Read at Royal North Shore Hospital Division of Surgery Meeting, Sydney, 12 September, 2011, Read at University of Western Sydney Orthopaedic Society, Sydney, 20 September, 2011, Read at Whitlam Musculoskeletal and Rehabilitation Symposium, Sydney, 20 September, 2011, Read at St George Hospital Division of Surgery Meeting, Sydney, 11 October, 2011

133 Rajat Mittal, Jay Dave, Chandra Dave, Victoria Ko, Sam Adie, Justine Naylor, Ian Harris Tourniquet application only during cement ﬁxation in total knee arthroplasty: a double-blind randomised controlled trial. Read at the Arthroplasty Society of Australia Meeting, Gold Coast, 3 June 2011, Read at Combined AOA/NZOA Annual Scientiﬁc Meeting, Rotorua, 9-14 October, 2011, Read at NSW AOA ASM, Sydney, 19 August, 2011

Ian Harris, Open reduction and internal ﬁxation fracture neck of femur, Read at AOA Continuing Orthopaedic Education Meeting: How I do it, Sydney, 14-15 July, 2011

Ian Harris Open reduction and internal ﬁxation fracture distal humerus, Read at AOA Continuing Orthopaedic Education Meeting: How I do it, Sydney, 14-15 July, 2011 Ian Harris Orthopaedic trauma surgeon M-F, 9-5? Read at SWAN XIX Trauma Conference, Sydney, 29 July 2011

Ian Harris Rates of lumbar spine surgery, revision and mortality rates for NSW, 2000-2008, Read at NSW AOA ASM, Sydney, 19 August, 2011

Ian Harris Rates of knee arthroscopy and conversion to TKR in NSW, 2000-2008, Read at NSW AOA ASM, Sydney, 19 August, 2011

Ian Harris Predictors of patient satisfaction after hip and knee replacement, Read at NSW AOA ASM, Sydney, 19 August, 2011

Ian Harris Outcomes of lumbar spine surgery in a Workers’ Compensation cohort, Read at NSW AOA ASM, Sydney, 19 August, 2011

Hamish Rae, Sam Adie, Ian Harris, Sarah Yong, Alan Dao, Justine Naylor, Pulsed electromagnetic ﬁeld stimulation for acute tibia fractures: a multicentre double blind randomised controlled trial, Read at AORA Annual Scientiﬁc Meeting, Merrijig, Victoria, 25-27 August 2011, Winner of Best Paper. Winner of Best Trauma paper.

Darnel Murgatroyd, Ian Cameron, Ian Harris, Understanding the effect of compensation on recovery from severe motor vehicle crashes: a qualitative study. Poster presentation at Australasian Compensation Health Research Forum, Institute for Safety, Compensation and Recovery Research, Melbourne, 13-14 October, 2011

134 Ian Harris, Getting research into practice, Read at Whitlam Musculoskeletal and Rehabilitation Symposium, Sydney, 20 September, 2011

Ian Harris, LARS ligament: what’s the evidence? Read at AOA Medicolegal Society Annual Meeting, Sydney, 27 November 2011

Navdeep Madan, Ian Harris, Sam Adie, Rajat Mittal, Justine Naylor, Trends in knee arthroscopy, Poster presentation at Ingham Institute Research Showcase Sydney, 2 December 2011

Ian Harris, Intertrochanteric fractures: Evidence based practice, Read at AO Masters Course: Current Concepts, Davos, 5-8 2011 December

Cheung B, Kamalasena G, Naylor JM, Mittal R, Harris IA, Yeo A, Walker R, Complications and diagnostic investigations after hip and knee arthroplasty in English proﬁcient and non-English proﬁcient patients, Read at Ingham Institute 6th Annual Research and Teaching Showcase, Sydney, 2 December 2011

Mittal R, Ko V, Adie S, Naylor JM, Dave J, Dave C, Harris IA, Hackett D, Ngo D, Dietsch S, Tourniquet use only during cement ﬁxation in Total Knee Arthroplasty(TKA): A double-blind randomised controlled trial, Read at Ingham Institute 6th Annual Research and Teaching Showcase, Sydney, 2 December 2011

Vicki Ko, JM Naylor, IA Harris, J Crosbie, A Yeo, Is centre based care superior to a home program after total knee replacement? A single blind randomized controlled trial. Read at Ingham Institute 6th Annual Research and Teaching Showcase, Sydney, 2 December 2011

Madan NS, Harris IA, Mittal R, Adie S, Naylor J, Yeo A, Trends of arthroscopic surgery in an Australian population: a short report, Read at Ingham Institute 6th Annual Research and Teaching Showcase, Sydney, 2 December 2011

Harris IA, Harris AM, Naylor JM, Adie S, Mittal R, Dao A Predictors of discordance in patient and surgeon satisfaction after hip and knee replacement, Read at Ingham Institute 6th Annual Research and Teaching Showcase, Sydney, 2 December 2011

Le Lievre HMJ,Murrell GAC. (2010) Long-term outcomes of arthroscopic capsular release for frozen shoulder. 2010 Bi-Annual Shoulder and Elbow Society of Australia Conference, Manly, 5-9th May 2010. Paper.

Peters K,McCallum S,Briggs L,Murrell GAC. (2010) A comparison of the outcomes of arthroscopic repair of partial- versus full-thickness rotator cuff tears. 2010 Bi-Annual Shoulder and Elbow Society of Australia Conference, Manly, 5-9th May 2010. Paper.

135 Walton JR,Murrell GAC. (2010) A comparative study of arthroscopic and open rotator cuff repair outcomes of 400 patients followed for two years or longer. Australian Conference of Science and Medicine in Sport, 3 - 6 November 2010, Port Douglas, Australia. Paper.

Le Lievre HMJ,Murrell GAC. (2010) Long-term outcomes of arthroscopic capsular release for frozen shoulder. Australian Conference of Science and Medicine in Sport, 3 - 6 November 2010, Port Douglas, Australia. Paper.

Xu C,Bonar F,Murrell GAC. (2010) Expression of neuronal markers in frozen shoulder. Australian Conference of Science and Medicine in Sport, 3 - 6 November 2010, Port Douglas, Australia. Paper.

Lam P,Murrell GAC. (2010) Ice vs. Gel, best strategies to reduce skin temperature? Australian Conference of Science and Medicine in Sport, 3 - 6 November 2010, Port Douglas, Australia. Paper. Bashay N,Lam P,Murrell GAC. (2010) The reliability of ﬁxed versus handheld dynamometer for shoulder strength testing. Australian Conference of Science and Medicine in Sport, 3 - 6 November 2010, Port Douglas, Australia. Paper. Yang Q,Murrell GAC. (2010) Turnover time in arthroscopic shoulder surgery: a reduction of 18% by three simple strategies. Australian Conference of Science and Medicine in Sport, 3 - 6 November 2010, Port Douglas, Australia. Poster. Lee G,Briggs L,Murrell GAC. (2010) Ultrasound measurement of shoulder capsule thickness for diagnosing frozen shoulder. Australian Conference of Science and Medicine in Sport, 3 - 6 November 2010, Port Douglas, Australia. Poster.

2011

Lam P., Shepherd H, Murrell GAC. (2011) Tape versus suture in rotator cuff repair: a biomechanical analysis of footprint compression and repair strength in ovine shoulders. Australian Conference in Science and Medicine in Sport, Fremantle, 19-22 October 2011. Paper 63.

Keighley G, Lam P, Hansen K, Murrell GAC. (2011) A randomized double blind clinical trial evaluating the effects of daily controlled vibration on the strength and range of movement of a shoulder following rotator cuff repair. Australian Conference in Science and Medicine in Sport, Fremantle, 19-22 October 2011. Paper 66.

Hansen K, Lam P, Keighley G,Murrell GAC. (2011) Effectiveness of vibration on pain following rotator cuff repair. Australian Conference in Science and Medicine in Sport, Fremantle, 19-22 October 2011 Paper 64.

136 Millican J, Murrell GAC. (2011) Can handheld dynamometers diagnose partial-thickness rotator cuff tears? Australian Conference in Science and Medicine in Sport, Fremantle, 19-22 October 2011. Paper 65.

Murrell GAC, Peters K. (2011) Permanent outperforms biodegradable anchors for arthroscopic stabilization for recurrent anterior shoulder instability. Australian Conference in Science and Medicine in Sport, Fremantle, 19-22 October 2011. Paper 62.

Tham L, Briggs L, Murrell GAC. (2011) Ultrasound changes after rotator cuff repair – is supraspinatus tendon thickness related to pain? Australian Conference in Science and Medicine in Sport, Fremantle, 19-22 October 2011. Paper 67.

Wu X, Murrell GAC. (2011) Intra-operative determinants of rotator cuff repair integrity: an analysis in 500 consecutive repairs. Australian Conference in Science and Medicine in Sport, Fremantle, 19-22 October 2011. Paper 68.

COMMUNITY ENGAGEMENT

None reported

137 SURGERY DEPARTMENT OF TRAUMA

DEPARTMENTAL STAFF*

Head of Department Dr Mary Langcake, BMBS, FRACS

Medical Staff Registrars/SRMO Dr Sergey Shchelokov Dr Javad Najaﬁ Dr Allan Kwok Dr Gerald Ip Dr Yusuf Moollan Dr Mark Macaranas Dr Mandeep Kaur

Interns Dr Thet Naing Soe Dr Samuel McDowell Dr Shiva Vissel Dr Bonnie Scurry Dr Linda Moore Dr Jennifer Hartley

Fellow Dr Anthony Morgan, MD, PhD

Senior Nursing Staff A/Prof Kate Curtis RN,Grad Dip Crit Care, MNurs (Hons), PhD (Trauma clinical nurse consultant, professorial fellow The George Institute for International Health, A/Prof Sydney Nursing School, Conjoint A/Prof St George Clinical School, UNSW) Taneal Wiseman RN, Grad Dip Crit Care, PhD candidate (Trauma clinical nurse consultant) Alana Clements RN, Masters Crit Care (Trauma Case Manager) Sarah Kourouche RN, Masters Emerg/Trauma Nurs (Trauma Case Manager) Belinda Munroe RN, Masters Adv Practice Emerg Nurs MPhil candidate (Trauma Case Manager) Peter Grove RN, Grad Cert Emerg (Trauma Data Nurse Specialist) Jane Leroi RN, Masters Emerg Nurs (Trauma clinic CNS)

138 RESEARCH GRANTS#

2011: International Program Development Fund Kate Curtis, Andrew Holland, Ian Cameron, Rebecca Ivers, Robert Crouch Establishing a Multidisciplinary Traumatic Injury Research Partnership with the United Kingdom (Southampton and Oxford). $20,000

2010: St George Honda Trauma Research Program Grant. Director Prof John Myburgh. CI Curtis, Saxena, Langcake. Research Fellows; Taylor, Glass ($150,000 over 3 years)

2010: The Austroads Crash Investigation Study [ACIS], Austroads. Costing Arm $33,000 CI: Curtis, Hatﬁeld, Watson for 2011

2010: NSW Institute of Trauma and Injury Management ‘Cost of Trauma in NSW’ $48,850

2010: Early Management of Severe Trauma Coordinator Travel Scholarship $1550

2009: St George Medical Research Foundation Establishment Grant ‘Cost of Trauma in NSW’ $10,000 CI K.Curtis, for 2010

2009: College of Nursing Consortium Fund Research Grant “Depression, Anxiety and Stress in major trauma patients”. $30,000. CI K.Curtis & K. Foster for 2010/2011

2009: Post Doctoral Fellowship in Trauma Care – USYD & School of Nursing. Duration – 3 years, $133,000 (2009-2011)

139 RESEARCH PROJECTS IN PROGRESS

Title Investigators

Clinical A/Prof Kate Curtis, Dr Rebecca Mitchell, Colman Taylor, Dr Mary Langcake, Prof Peter Cameron, Dr Peter Clark, Prof Zsolt Balogh, Dr Tony Joseph, Mrs Trish Trauma Patient Outcomes in New South Wales. McDougall et al. St George Hospital, University of Sydney, The NSW Institute of Trauma and Injury Management & The George Institute for Global Health Clinical A/Prof Kate Curtis, Black, Dr Mary Langcake, Colman Taylor, Prof John Myburgh, Dr Rebecca Mitchell, Mrs Trish McDougall et al. University of Sydney: Nursing. Cost of Major Trauma in NSW. Health Sciences. UNSW IRMC. The George Institute for International Health. NSW Institute of Trauma and Injury Management The relationship between mental health and major trauma patients of an Australian Trauma Centre: A mixed methods Ms Taneal Wiseman, A/Prof Kate Curtis & A/Prof Kim Foster explanatory study.

What makes an emergency nurse? An investigation into Belinda Kennedy, A/Prof Kate Curtis, A/Prof Donna Waters personality types and retention & Dr Judy Hyde

Ms Alana Clements, A/Prof Kate Curtis, Ms Leanne Horvat The scribe nurse in major trauma: Does level of experience & Dr Mary Langcake. St George Hospital - Departments improve quality of documentation and leadership? of Trauma and Emergency Subdural Haemmorrhage in older persons: a comparison of Dr Stephen Asha, Dr Jaenette Keady, A/Prof Kate Curtis outcomes between those on anticoagulants at the time of injury & Dr Saeed Kohan. St George Hospital - Department of and those not Trauma, Emergency and Neurosurgery Dr Stephen Asha, A/Prof Kate Curtis, Dr Allan Kwok, Does the use of patient controlled analgesia in blunt thoracic Dr Mary Langcake. St George Hospital Departments of trauma reduce complications and improve outcome? Trauma and Emergency Rear Seat Safety Project Rear Seat Safety Project Neuroscience Research Australia (Dr Julie Brown, Dr Julie Hatﬁeld) & A/Prof Kate Curtis

ORIGINAL PEER-REVIEWED PUBLICATIONS

Mitchell R, Williamson A, Curtis K. What is the potential of trauma registry data to be used for road trafﬁc injury surveillance and informing road safety policy? Journal of Safety Research. 2011, 42(5):345-350

Wiseman T & Curtis K. Gunshot wounds to the leg causing neurovascular compromise – A case study, 2011. Australasian Emergency Nursing Journal. 4(4):264-69

Munroe B & Curtis K. Assessment, monitoring and emergency nursing care in blunt chest injury: A Case Study. 2011. Australasian Emergency Nursing Journal. 14(4);257-263

140 Kourouche, S, Curtis K, Watson W, Mitchell R, Rankin T, Chong S. Identifying risk and raising awareness in Older Person Trauma: A trauma centre initiative. Journal of Trauma Nursing, 2011, 18(3); 163-172.

Curtis K, Chong S, Mitchell R, Newcombe M, Black D, Langcake M. Outcomes of Severely Injured Adult Trauma Patients in an Australian Health Service: Does trauma centre level make a difference? World Journal of Surgery. 2011, 35; 2332-2340

Curtis K, Mitchell R, Dickson C, Black D, Lam M. Do AR-DRGs adequately describe the trauma patient episode in New South Wales, Australia? Health Information Management Journal. 2011, 40(1):7-13.

Murphy M, Seggie J, Edwards C, Curtis K. Emergency Department Trauma Redesign in a Level 1 Trauma Centre. Australasian Emergency Nursing Journal. Australasian Emergency Nursing Journal. 2011, 14 (1):50-8

Curtis K, Tzannes A & Rudge T. How to talk to Doctors – A guide for effective communication. International Nursing Review. 2011, 58(1),13-20

Curtis K, Olivier J, Mitchell R, Cook A, Rankin T, Rana A, Watson W, Nau T. Evaluation of a Tiered Trauma Call System in a Level 1 Trauma Centre. Injury, 2011, 42(1): 57–62

Curtis K & Asha S. Blunt cardiac injury as a result of a motor vehicle collision: A case study. Australasian Emergency Nursing Journal 2010, 13(4): 124-129.

Nau T, Curtis K. Trauma Case management - Schluessel zur Interdisziplinaritaet. Clinicum. 2010, 9:32

Ursic C & Curtis K. Thoracic and Neck Trauma Part 4. International Emergency Nursing, 2010, 18, 177– 180

Mitchell R, Curtis K, Watson W & Nau T. Age differences in fall-related injury hospitalisations and trauma presentations. Australasian Journal on Ageing, 2010, 29 (3): 117–125

Ursic C & Curtis K. Thoracic Trauma Injuries and Management part 3, International Emergency Nursing. 2010, 18: 158-165.

141 Ursic C & Curtis K. Thoracic Trauma Injuries and Management part 2, International Emergency Nursing. International Emergency Nursing,2010, 18: 99 - 108

Curtis K. Emergency nurses—Where will we be in 25 years? Australasian Emergency Nursing Journal. 2010, 13: p41

Skapetis T & Curtis K. Emergency Management of Dental Trauma. Australasian Emergency Nursing Journal, 2010, 13 (1):30-34

Ursic C & Curtis K. Thoracic and Neck Trauma part 1. International Emergency Nursing. International Emergency Nursing, 2010, 18:47-53

OTHER PUBLISHED MATERIAL (Books, book chapters)

Book Curtis K & Ramsden C. Emergency and Trauma Care for nurses and paramedics. Elsevier: Sydney; 2011.

Book chapters King K, Evans J, Curtis K. Abdominal and genitourinary trauma. In: Curtis K, Ramsden C, eds. Emergency and Trauma Care, for nurses and paramedics. Sydney: Elsevier; 2011.

Caldwell E, Delprado A, Curtis K. An Overview of Trauma. In: Curtis K, Ramsden C, eds. Emergency and Trauma Care, for nurses and paramedics. Sydney: Elsevier; 2011.

Langcake M, Curtis K, Ursic C. Thoracic and Neck Trauma. In: Curtis K, Ramsden C, eds. Patient assessment and essentials of care, for nurses and paramedics. Sydney: Elsevier; 2011.

Fairnsworth L, Curtis K. Patient assessment and essentials of care. In: Curtis K, Ramsden C, eds. Emergency and Trauma Care, for nurses and paramedics. Sydney: Elsevier; 2011.

142 PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

Curtis K Invited speaker: Westmead Hospital Trauma Nursing Symposium. The future of trauma nursing in Australia. October 20th, Sydney

Curtis K Invited speaker: Swan X1X Trauma Conference. Money well spent? Costing trauma in NSW and Expert Case Panel. July 29th-30th 2011, Sydney

Curtis K, Chong S, Mitchell R, Newcombe M, Black D, Langcake M (2011). Outcomes of Severely Injured Adult Trauma Patients in an Australian Health Service. Does trauma centre level make a difference? From Roadside to Recovery – Successful Systems of Trauma Care. National Trauma Research Institute. 18th – 19th November 2011, Melbourne

Willensberg L, Curtis K, Taylor C. The cost of major trauma – A systematic review From Roadside to Recovery – Successful Systems of Trauma Care. National Trauma Research Institute. 18th – 19th November 2011, Melbourne

Ogilvie R, Foster K, McCloughen A & Curtis K. Surviving traumatic physical injury: a systematic synthesis of current knowledge. National Trauma Research Institute. 18th – 19th November 2011, Melbourne – BEST FREE PAPER

Mitchell RJ, Curtis K, Chong S, Holland AJA, Soundappan SVS, Wilson K, Cass DT. Paediatric trauma outcomes in NSW: factors inﬂuencing survival. From Roadside to Recovery – Successful Systems of Trauma Care. National Trauma Research Institute. 18th – 19th November 2011, Melbourne

Mitchell RJ, Curtis K, Chong S, Holland AJA, Soundappan SVS, Wilson K, Cass DT. Paediatric trauma outcomes in NSW: factors inﬂuencing survival. Understanding Mortality Data 2011 Workshop. Commission for Children and Young People and Child Guardian. 31st October – 1st November 2011 Brisbane.

Munroe B, Curtis K, Dwyer D, Langcake M (2011). ChIP: Chest Injury Pager - an innovative early multidisciplinary approach to blunt chest injury. 9th International Conference for Emergency Nurses. 28th September to 1st October 2011. Adelaide

Curtis K, Chong S, Mitchell R, Newcombe M, Black D, Langcake M (2011). Outcomes of Severely Injured Adult Trauma Patients in an Australian Health Service. Does trauma centre level make a difference? 9th International Conference for Emergency Nurses. 28th September to 1st October 2011. Adelaide

Langcake M (2011). The Relevance of Military Trauma Care to Civilian Practice. AMMA Conference, 21-23 October 2011, Melbourne.

Curtis K. Invited speaker: Westmead Hospital Trauma Nursing Symposium. The future of trauma nursing in Australia. October 20th, Sydney 201

143 Langcake M (2011). From Sawbones to Saviours - A History of Civil War Surgery. Uniformed University of the Health Sciences Annual Trauma Day, 25 August 2011, Bethesda, Maryland, USA.

Curtis K. Invited speaker: Swan X1X Trauma Conference. Money well spent? Costing trauma in NSW and Expert Case Panel. July 29th-30th 2011, Sydney

Langcake M (2011). Debate - Trauma Surgeons - An Endangered Species - Afﬁrmative Team. RACS Annual Scientiﬁc Congress, 4-6 May 2011, Adelaide.

Curtis K Keynote Speaker, Trauma 2010 (National Trauma Research Institute & Australasian Trauma Society), 20th November 2010, Melbourne

Asha S, Grant N, Curtis K, Smart R & Compagnoni (2010). Comparison of radiation exposure of trauma patients from diagnostic radiology procedures before and after the introduction of a ‘panscan’ protocol. Australasian College for Emergency Medicine, 27th Annual Scientiﬁc Meeting. 21-25 November, Canberra.

Macaranas M, Curtis K, Chung A, Mitchell R, Langcake M (2010). Incidence, Management and Outcome of hypothermia in trauma patients: The experience of a level 1 trauma centre. Trauma 2010 (National Trauma Research Institute & Australasian Trauma Society), 20th November 2010, Melbourne

Curtis K Invited speaker, Closing the Divide: Scholarly research and clinical practice. 8th International Conference for Emergency Nurses. 14-16th October 2010, Canberra

Langcake M Invited speaker, Afghanistan - was I ready for that? Australian Military Medical Association October 2010, Canberra Curtis K Keynote speaker, Annual Royal Brisbane and Women’s Hospital Symposium, 11-15th October 2010, Brisbane

Langcake M Invited speaker, Penetrating thoracic trauma, Massive transfusion. Trauma up the Coast, September 2010, Ettalong

Cook A Invited speaker, Trauma up the Coast, September 2010, Ettalong Langcake & Estell: Submitted paper - Improving the trauma patient journey through the hospital system Improving the Health Care Experience Conference, September 2010 Sydney.

Langcake M Invited speaker, Injury - Triage systems - what are they and do they work? Acute surgical units - the Australian experience, The relevance of military trauma care to civilian practice. Auckland, August 2010

Curtis K Keynote speaker, Hawaiian Islands Trauma Symposium, July 24/25th 2010, Honolulu

M. Langcake, K. Curtis Invited speakers/Panel member. NSW Institute of Trauma and Injury Management Trauma education evening in South East Sydney Illawarra Health, July 6th, 2010, Sydney

144 Curtis K Invited speaker, Indian Council of Medical Research Ministry of Health & Family Welfare, Govt. of India & The George Institute and The University of Sydney Workshop on Road trafﬁc injuries. 28 – 30 June, 2010, The George Institute, Sydney

Cook A Invited Speaker, ACCCN ICE Conference, Airway Emergencies and Trauma, May 2010, Brighton Le Sands, Sydney

Langcake M Invited speaker, RACS Annual Scientiﬁc Congress. Topics - Afghanistan was I ready for that and Leaders in our healthcare services - how do we train them? May 2010, Perth, Western Australia.

Cook A Invited Speaker, AUSTRAUMA, Invited Speaker, Dealing with Difﬁcult Doctors, Feb 2010, Sydney.

COMMUNITY ENGAGEMENT

St George Hospital Trauma Service hosts 4 Early Management of Severe Trauma courses a year. The EMST course is a 2.5 day intensive course in the management of injury victims in the ﬁrst 1–2 hours following injury. The emphasis is on developing life saving skills and a systematic clinical approach. It is designed for all doctors who are involved in the early treatment of serious injuries in urban or rural areas, whether or not sophisticated emergency facilities are available. On each course 4 nurse observers participate also. Dr Langcake has also presented trauma topics to the Lions Club, the Lamrock Committee and the Medical Women’s Society of NSW.

Since 2004 St George Hospital Trauma and Allied Health services have joined together to offer local seniors (aged 50 years and older) a Safety Seminar providing tips on home safety, access to information, and community resources and products that will help them to prevent falls and injuries. This very successful free seminar is held at St George Leagues Club.

Dr Langcake and A/Prof Curtis are supervising two independent learning project medical students (UNSW) and A/Prof Curtis is co-supervising six research degree students either through Sydney Nursing School or UNSW.

145 SURGERY DEPARTMENT OF VASCULAR SURGERY

DEPARTMENTAL STAFF*

Head of Department K.C. Hanel MB BS FRACS DDU

Visiting Medical Ofﬁcers E Farmer MB BS FRACS DDU L. D. Lemech MB BS FRACS DDU G. McMullin MB BS FRACS FRCS DDU J. Iliopoulos MB BS (Hons1) FRACS( Cardiothoracic and vascular) PhD

Vascular trainees 2010 Mayur Krishnaswamy- Vascular surgery trainee Nagy Andrawis - FRACS General Surgery John Ozman - General surgery trainee

2011 Taraneh Amir-Nezami - Vascular trainee Mena Shehata - FRACS General Surgical Trainee Mario Malkoun - General Surgical Trainee

RESEARCH GRANTS

None reported

146 RESEARCH PROJECTS IN PROGRESS

Title Investigators

Chief Investigator Associate Professor Robert Fitridge, Prospective evaluation of a model to predict outcomes following The Queen Elizabeth Hospital, Adelaide, South Australia. Endovascular Aortic Aneurysm Repair. St George Principal Investigator L. D. Lemech.

Managing trauma in the austere environment: a project for J. Iliopoulos, chief investigator; Prof WR Walsh special operations command of the Australian army (S&ORL NSW)

J Iliopoulos, Chief investigaror Prof. WR Walsh Adhesions in lumbar spine surgery. (S&ORL UNSW)

Training of defence force staff in simple tissue handling J Iliopoulos, Cheif investigator Prof WR Walsh procedures in a sheep carcus model. (S&ORL UNSW)

Evaluation of bioresorbable materials for reduction of pelvis soft J. Iliopoulos, Chief Investigator Prof WR Walsh tissue attachments in a porcine model (S&ORL UNSW)

Renal Dysfunction in patients undergoing Endoluminal grafting of Principal Investigator - Taranei Amir-Nizami Abdominal Aortic Aneurysms.

ORIGINAL PEER-REVIEWED PUBLICATIONS

None reported

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

G Mcmullen, Prescribing for elderly patients. Editors; Stephen Jackson, Paul Jansen and Arduino Mangoni. J Wiley and sons Ltd 2010. Chapter 41 “ Leg Ulceration”

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

None reported

COMMUNITY ENGAGEMENT

None reported

147 CANCER CARE DEPARTMENT OF HAEMATOLOGY

DEPARTMENTAL STAFF*

Head of Department Professor Beng Chong, MBBS, PhD, FRCP, FRACP, FRCPA Professor, Department of Medicine UNSW Director Clinical Haematology St George Clinical School The St George Hospital

Basic research into Transcription regulation of platelet production, biology of Oncogenes: Fli- 1, GATA-1, PU-1 and FOG-1and Cardiac stem cells. Translational Research - Mechanisms of drug-induced thrombocytopenia. Clinical research into prophylaxis and treatment of venous thromboembolism and Immune thrombocytopenia.

NHMRC Project Grant assessment panel member 2010 Member of the Board of St George Medical research Foundation and Deputy Chair, Scientiﬁc Advisory Committee, St George Medical research Foundation. Member, Medical and Dental Appointments Committee, St George Hospital, Sydney Member of Clinical Council, St George Hospital, Sydney Co-chair, Platelet Immunology Subcommittee, International Society of Thrombosis and Haemostasis Vice-President, Australian Bid Committee, International Society of Thrombosis and Haemostasis

Senior Medical Staff

Professor Szu-Hee Lee Szu-Hee Lee is Professor (Conjoint) and Senior Staff Specialist in Haematology at St George Hospital, Sydney, Australia. He graduated in medicine from the University of Cambridge and University College Hospital, London, UK, and trained in haematology at the John Radcliffe Hospital in Oxford, UK. His research interests are in laboratory and experimental haematology. Chair of the Science and Education Committee of the International Society of Haematology, Asia- Paciﬁc Division (ISHAPD) since 1997 . Member Board of Directors of the International Society of Laboratory Hematology (ISLH) in 2009. Vice-President of the International Council for Standardization in Hematology (ICSH) since 2009. Co-Chief Editor of the International Journal of Laboratory Hematology since 2010.

Staff Specialists

Dr Sundra Ramanathan, MBBS, FRACP, FRCPA Dr Ramanathan’s interests are particularly in malignant haematology and autologous stem cell transplant. Dr Fernando Roncolato, B Med FRACP FRCPA

148 Dr Roncolato has a clinical and research interest in Lymphoma.

Dr Xavier Badoux, MBBS, FRACP, FRCPA Dr Badoux’s clinical research involves malignant haematological disorders including treatment of acute and chronic leukaemias, myeloproliferative and lymphoproliferative neoplasms.

Dr Shir-jing Ho, MBBS, FRACP, FRCPA Dr Ho’s clinical research includes treatment of acute and chronic leukaemias and lymphoma, and thrombosis and haemostasis, as well as a laboratory interest in haemostasis and platelet disorders.

Dr Amanda Hugman, MBBS, FRACP, FRCPA Research interest in epidemiology.

Junior Medical Staff Laboratory advanced trainees: Carrie van der Weyden, Shri Desai, Ward advanced trainees: Sylvia Zheng

Research Staff Senior Research Staff Post–doctoral Scientists: José Perdomo, Feng Yan, Xing-Mai Jiang, Jim Fang

Research scientist: Zohra Ahmedi

Research Students Ph D Research students: Dr Philip Choi, Sheng-yi Liu, Jaa Yien New, Muna Araqi

Scientiﬁc Staff Haematology Laboratory Manager: Sudha Pillai, Deputy Manager: Susan Smith,

Chief Scientists Coagulation lab – Rosalie Gemmell Blood Bank – Peter Loizou, Morphology: Nella Mangos/Nicole Lewis Bone Marrow transplant lab -Christine Wassell; Senior Technical Ofﬁcers: Karen staff, Rema Nasr

149 Nursing Research Staff CNC: Nicole Goodman,: NUM 4 North Marisa Wilson Oncology Outreach: Cassandra Hobbs, Jo-Ann Cryer, Cancer Care NUM: Lucy Burns, Apheresis CNC: Patricia Morris Clinical Trials Unit Manager Roslyn Ristuccia BSc DipCompSc MMedSc(Epi)

Clinical Research Coordinators Karina Chui RN Sarah Davidson RN Lorraine King RN Margaret Loizou BSc Elena Mendoza-Simon BSc Rhona Maclean BSc (Pharmacy) – Clinical Trials Pharmacist Research Administration Jane Hagin Kareen Fierro Jessica Ristuccia

150 RESEARCH GRANTS#

Category I - Nationally Competitive Grants:

Program Grant NHMRC455395. CN Chesterman, MC Berndt,BH Chong, PJ Hogg, LM Khachigian, CR Parish, RO Stocker. Vascular Biology $14,516,629.00 2007-2011

Project Grant NHMRC APP1012409, RM 08796, InfoEd Ref: RG102962 BH Chong, M Davenport Drug-induced immune thrombocytopenia $491,706.00 Jan 2011-Dec 2013

Project Grant NHMRC RM09942 APP1028803BH BH Chong, C Parish Heparin-induced thrombocytopenia and thrombosis: Better understanding of pathogenesis and improving diagnosis and treatment. $631,010.00 Jan 2012-Dec 2014

Category II - Other competitive grants:

NSW Cancer Institute Dr Sundra Ramanathan Cancer Trials Nurses and Data Manager’s Grant 2010/11 $165360 NSW Cancer Institute Dr Shir-jing Ho Cancer Trials Nurses and Data Manager’s Grant 2010/11 $82680

St George Medical Research Foundation Post-Graduate Scholarship Philip Choi, 2010

Category III – Industry and other research funding:

Industry Funded Clinical Research Projects: Professor Beng Chong, Dr Sundra Ramanathan, Dr Fernando Roncolato, Dr Xavier Badoux, Dr Shir-jing Ho, Dr Amanda Hugman, Dr Michael Harvey, Principal investigators.

2010 Grant Funds: $594,700

2011 Grant Funds: $387,900

151 COMMERCIAL Funding currently held BH Chong

Title / Investigators Source Period Funds (Total)

EINSTEIN VTE treatment study: Oral direct oral factor Xa inhibitor Bayer / Rivaroxaban in patients with acute symptomatic deep vein thrombosis 2007-2012 $440,000.00 Covance and pulmonary embolism (St George Hospital) BH Chong.

EINSTEIN VTE treatment study: Oral direct oral factor Xa inhibitor Bayer / Rivaroxaban in patients with acute symptomatic deep vein thrombosis 2007-2012 $150,000.00 Covance and pulmonary embolism. (Sutherland Hospital) BH Chong.

AMPLIFY TREATMENT: A Safety and Efﬁcacy Trial Evaluating the Use of MS/Pﬁzer/PPD Apixaban in the Treatment of Symptomatic Deep Vein Thrombosis and (Amplify 2009-2012 $125,000.00 Pulmonary Embolism BH Chong Treatment)

AMPLIFY EXTENSION: A safety and efﬁcacy trial evaluating the use of MS/Pﬁzer/PPD Apixaban for the extended treatment of deep vein thrombosis and (Amplify 2008 –2012 $180,000.00 pulmonary embolism BH Chong. Extension)

The Edoxaban HOKUSAI VTE Study: A Phase 3, Randomized, Double- Blind, Double-Dummy, Parallel-Group, Multi-Center, Multi-National Study Daiuchi for the Evaluation of Efﬁcacy and Safety of (LMW) Heparin/ Edoxaban 2010-2012 $60,000.00 Sanko Versus (LMW) Heparin/Warfarin In Subjects with Symptomatic Deep-Vein Thrombosis and/or Pulmonary Embolism. BH Chong

ASPIRE: Aspirin to prevent recurrent venous thromboembolism. A multicentre, randomised, double-blind, placebo-controlled clinical trial NHMRC -CTC 2003-2012 $5,000 examining the efﬁcacy and safety of low-dose aspirin after initial oral anticoagulation to prevent recurrent venous thromboembolism. BH Chong

(Eltrombopag Extended Dosing Study): An extension study of eltrombopag $85,000 for olamine (SB-497115-GR) in adults, with idiopathic thrombocytopenic GSK 2007-2013 2007-2012 purpura (ITP), previously enrolled in an eltrombopag study. BH Chong

A Randomized, Double-blind, Placebo-controlled Study of the JAK Inhibitor INCB018424 Tablets Administered Orally to Subjects With Primary Incyte $48,000 for 2010-2014 Myelofibrosis, Post-Polycythemia Vera Myelofibrosis or Post-Essential Corporation 2010-2012 Thrombocythemia Myelofibrosis. BH Chong

A Prospective, Phase IV, Open-Label, Multi-Center Study Evaluating Changes in Bone Marrow Morphology in Adult Subjects Receiving $42,000 for Amgen 2010-2015 Romiplostim for the Treatment of Thrombocytopenia Associated with 2010-2012 Immune (Idiopathic) Thrombocytopenia Purpura (ITP). BH Chong

A global, observational, non-interventional study collecting effectiveness, $35,000 for safety and quality of life data on patients with Paroxysmal Nocturnal Alexion 2010-2015 2010-2012 Haemoglobinuria (PNH) Disease. BH Chong

Chong BH: Chair, International ITP Registry: A Multi-centre, prospective disease registry for Steering ~$180,000 for adults diagnosed with primary immune thrombocytopenia purpura (ITP) Committee. 2011-2021 2011-2012 Asia-Paciﬁc, Middle Eastern and S American countries. BH Chong Unrestricted grant from GSK

An Observational Study of Neutropenia in Subjects Being Treated for $7,000 for Amgen 2011-2015 Relapsed or Relapsed/Refractory Multiple Myeloma. BH Chong 2011

152 RESEARCH GRANTS#

Trial Tumour Principal Trial Nickname Clinical Trials Conducted Sponsor Registration # Grouping Investigator

A global, observational, non- interventional study collecting effectiveness, safety and quality of Alexion PNH Registry NA PNH Alexion Beng Chong life data on patients with Paroxysmal Nocturnal Haemoglobinuria (PNH) Disease

An Australasian, phase II, multicentre, randomised, dose intensiﬁcation study investigating oral ﬂudarabine, ACTRN ***ALLG CLL5 oral cyclophosphamide and i.v. 1260800 CLL ALLG Shir-jing Ho OFOCIR rituximab (poFCivR) tolerance in 0404325 previously untreated elderly (= 65 years old) patients with chronic lymphocytic leukaemia

Response post Tyrosine Kinase Inhibitor: assessment of sensitivity ACTRN ***ALLG CML10 and therapeutic response to next- 1261000 CML ALLG Shir-jing Ho RESIST line therapy in CML: The Australasian 0055000 RESIST study

A Phase I/II trial to determine safety ACTRN and with 5-azacitidine (Vidaza) ***ALLG MDS3 1260700 MDS ALLG Shir-jing Ho and Thalidomide Myelodysplastic 0283471 Syndromes (MDS)

A Randomised Phase II study comparing the efﬁcacy of 5azacitidine alone versus combination therapy with ACTRN ***ALLG MDS4 lenalidomide and 5azacitidine 1261000 MDS ALLG Shir-jing Ho in patients with higher risk 0271000 myelodysplastic syndromes (MDS) and low marrow blast count acute myeloid leukaemia (AML)

A multicentre randomised phase III study of low-dose thalidomide, prednisolone and zoledronic acid ACTRN Multiple ***ALLG MM6 versus prednisolone and zoledronic 1260700 ALLG Kiran Phadke Myeloma acid for post-asct maintenance 0382471 therapy in patients with multiple myeloma

A phase 3, multicentre, randomized, controlled study to determine the efﬁcacy and safety of cyclophosphamide, lenalidomide 2008- Sundra ***ALLG MM11 Myeloma ALLG and dexamethasone (crd) versus 008599-15 Ramanathan melphalan (200 mg/m2) followed by stem cell transplant in newly diagnosed multiple myeloma subjects

Early Treatment Intensiﬁcation with R-ICE Chemotherapy Followed by Autologous Stem Cell Transplantation Using Z-Beam for ACTRN Large B-Cell ***ALLG NHL21 patients with poor prognosis Diffuse 1260900 ALLG Shir-Jing Ho Lymphoma Large B-Cell Lymphoma as Identiﬁed 1077257 by Interim PET/CT Scan Performed After Four Cycles of R-CHOP-14 Chemotherapy

153 Trial Tumour Principal Trial Nickname Clinical Trials Conducted Sponsor Registration # Grouping Investigator

Early Treatment Intensiﬁcation with R-ICE Chemotherapy Followed by Autologous Stem Cell Transplantation Using Z-BEAM for 2008- Sundra ***ALLG NHL25 Patients with Poor Prognosis Diffuse Lymphoma REMARC 008202-52 Ramanathan Large B-Cell Lymphoma as Identiﬁed by Interim PET/CT Scan Performed After Four Cycles of R-CHOP-14 Chemotherapy

A Phase II study in adult patients with newly diagnosed chronic- phase chronic myeloid leukaemia of initial intensiﬁed imatinib therapy ACTRN ***ALLG TIDEL II and sequential dose-escalation 1260700 CML ALLG Shir-jing Ho followed by treatment with nilotinib 0325404 in suboptimal responders to determine the rate and duration of major molecular response

An Observational Study of Amgen Multiple Neutropenia in Subjects Being NA Myeloma Amgen Beng Chong Myeloma Registry Treated for Relapsed or Relapsed/ Refractory Multiple Myeloma

A Prospective, Phase IV, Open- Label, Multi-Center Study Evaluating Changes in Bone Marrow Morphology in Adult Subjects AMGEN 2008009 Receiving Romiplostim for the NCT00907478 ITP AMGEN Beng Chong ITP BMT Treatment of Thrombocytopenia Associated with Immune (Idiopathic) Thrombocytopenia Purpura (ITP)

A Randomised, Double Blind, Placebo Controlled Study Evaluating the Efﬁcacy and AMG MDS Safety of Romiplostim Treatment NCT00614523 MDS AMGEN Beng Chong 20060198 of Thrombocytopenia in Subjects with Low or Intermediate-1 Risk Myelodysplastic Syndrome (MDS)

A safety and efﬁcacy trial evaluating the use of Apixaban for the AMPLIFY Extension BMS/ extended treatment of deep NCT00633893 VTE Beng Chong CV057 Pﬁzer/PPD vein thrombosis and pulmonary embolism.

A Safety and Efﬁcacy Trial Evaluating AMPLIFY Treatment the Use of Apixaban in the Treatment BMS/ NCT00643201 VTE Beng Chong CV056 of Symptomatic Deep Vein Thrombosis Pﬁzer and Pulmonary Embolism

Aspirin to prevent recurrent venous thromboembolism. A multicentre, randomised, double-blind, ACTRN placebo-controlled clinical trial ***ASPIRE 1260500 VTE NHMRC Beng Chong examining the efﬁcacy and safety 0004662 of low-dose aspirin after initial oral anticoagulation to prevent recurrent venous thromboembolism

A Randomized Phase 4 Study Comparing 2 Intravenous B1771007 Mantle Pﬁzer / Sundra Temsirolimus (TEMSR) Regimens in NCT01180049 Lymphoma Cell Lymphoma Quintiles Ramanathan Subjects With Relapsed, Refractory Mantle Cell Lymphoma

154 Trial Tumour Principal Trial Nickname Clinical Trials Conducted Sponsor Registration # Grouping Investigator

A two-stage phase 1b study to investigate the pharmacokinetics Follicular Sundra BP22333 in patients with follicular lymphoma NCT00930514 Roche Lymphoma Ramanathan (FL) as part of maintenance treatment

An open-label, multi-center, three arm randomized, phase III study to compare the efﬁcacy and safety of RO5072759+chlorambucil (GClb), Sundra CLL 11 BO21004 NCT01010061 CLL Roche rituximab + Chlorambucil (RClb) Ramanathan or chlorambucil (Clb) alone in previously untreated CLL patients with comorbidities.

COntrolled MyeloFibrosis Study with COMFORT-I NCT00952289 MyeloFibrosis Incyte Beng Chong ORal JAK inhibitor Treatment

Heparin-induced thrombocytopenia (HIT): Characterization of the ***CTBR HITS pathogenic and non-pathogenic NA HITS STG Beng Chong antibodies, and studies to improve laboratory diagnosis and treatment.

A pilot study for mandatory VTE Risk Assessment and Prophylaxis ACTRN ***CTBR007 Implementation for cost effectively St George 1261000 VTE Beng Chong RAPIMED improving VTE outcomes in Hospital 1001088 hospitalized medical patients: a randomised controlled study.

A Multi-centre, prospective disease ***CTBR017 registry for adults diagnosed with International ITP NA ITP STG Beng Chong primary immune thrombocytopenia Registry (ITP) in international countries.

Oral direct factor Xa inhibitor ACTRN Einstein Treatment Rivaroxaban in patients with acute Bayer - 1260700 VTE Beng Chong 11702 STG symptomatic deep-vein thrombosis Covance 0222448 or pulmonary embolism

Oral direct factor Xa inhibitor ACTRN Einstein Treatment- Rivaroxaban in patients with acute 1260700 ITP Bayer Beng Chong 11702-TSH symptomatic deep-vein thrombosis 0222448 or pulmonary embolism.

Oral direct factor Xa inhibitor ACTRN Einstein Treatment Rivaroxaban in patients with acute Bayer - 1260700 VTE Beng Chong 11702 STGPrivate symptomatic deep-vein thrombosis Covance 0222448 or pulmonary embolism

Extending molecular responses with Nilotinib in newly diagnosed chronic Novartis / Sundra ENESTxtend NCT01254188 CML myeloid leukemia (CML) patients in Paraxel Ramanathan chronic phase (ENESTxtnd)

An open-label, multi-centre, randomised, phase Ib study to investigate the safety and efﬁcacy EURACT 2008- of RO5072759 given in combination Sundra GAUDI BO21000 01643-19 and NHL Roche with CHOP, FC or bendamustine Ramanathan NCT00825149 chemotherapy in patients with CD20+ B-cell follicular non-Hodgkin’s lymphoma.

155 Trial Tumour Principal Trial Nickname Clinical Trials Conducted Sponsor Registration # Grouping Investigator

A Phase 3, Randomized, Double- Blind, Double-Dummy, Parallel- Group, Multi-Center, Multi-National Study for the Evaluation of HOKUSAI VTE Study Efﬁcacy and Safety of (LMW) NCT00986154 VTE Hokusai Beng Chong Heparin/ Edoxaban Versus (LMW) Heparin/Warfarin In Subjects with Symptomatic Deep-Vein Thrombosis and/or Pulmonary Embolism

EXTEND (Eltrombopag eXTENded Dosing Study): An extension study of eltrombopag olamine (SB- ITP EXTEND 497115-GR) in adults, with idiopathic NCT00351468 ITP GSK Beng Chong thrombocytopenic purpura (ITP), previously enrolled in an eltrombopag study.

Long term eltrombopag observational study- A long term observational ocular safety follow-up study on adults who have received ITP LENS NCT00643929 ITP GSK Beng Chong study medication (SB-497115-GR/ eltrombopag olamine or placebo) in a Phase II or phase III clinical study evaluating eltrombopag.

Magellan- Multicenter, randomized, parallel Group Efﬁcacy and safety study for the prevention of venous Magellan-STG NCT00571649 VTE Bayer Beng Chong thromboembolism in hospitalized medically ill patients comparing rivaroxaban with enoxaparin

A Randomised, Double-Blind, Double-Dummy, Parallel Group Study to Compare YM150 bid and qd ONYX III Hip STG Doses and Enoxaparin for Prevention NCT00902928 VTE Astellas Beng Chong Private of Venous Thromboembolism in Subjects Undergoing Elective Hip Replacement Surgery

A Randomised, Double-Blind, Double-Dummy, Parallel Group Study to Compare YM150 bid and qd ONYX III Hip TSH Doses and Enoxaparin for Prevention NCT00902928 VTE Astellas Beng Chong of Venous Thromboembolism in Subjects Undergoing Elective Hip Replacement Surgery

A Phase III randomized, double blind, placebo controlled multicentre study of panobinostat for maintenance of response in Hodgkin’s PATH CLBH589E2301 NCT01034163 Novartis Shir-jing Ho patients with Hodgkin’s Lymphoma Lymphoma who are at risk for relapse after high dose chemotherapy and autologous stem cell transplant

Audit of sickle cell disease (SCD) ***Red Cross Sickle patients in Sydney (A Transfusion NA Sickle cell Red Cross Shir-jing Ho Cell project Laboratory-Based Perspective)

156 Trial Tumour Principal Trial Nickname Clinical Trials Conducted Sponsor Registration # Grouping Investigator

Outpatient Ifosfamide, Etoposide plus Rituximab (R-IE) for salvage in ACTRN patients > 60 years with relapsed Sundra ***R-IE (Westmead) 01260600 Lymphoma Westmead or refractory CD20 positive diffuse Ramanathan 0373572 large B-cell lymphoma who are not candidates for stem cell transplant

A Multinational, Multicentre, Randomised, Double Blind Study comparing the Efﬁcacy and Safety of AVE5026 with enoxaparin SAVE-ABDO STG NCT00679588 VTE Sanoﬁ-Aventis Beng Chong for the Prevention of Venous Thromboembolism in Patients Undergoing Major Abdominal Surgery (SAVE_ABDO)

A Multinational, Multicentre, Randomised, Double Blind Study comparing the Efﬁcacy and SAVE-ABDO Safety of AVE5026 with enoxaparin NCT00679588 VTE Sanoﬁ-Aventis Beng Chong STGPrivate for the Prevention of Venous Thromboembolism in Patients Undergoing Major Abdominal Surgery (SAVE_ABDO)

A Multi-National, Randomized, Double-blind, placebo-controlled study to evaluate the efﬁcacy and Cancer safety of AVE5026 in the prevention SAVE-ONCO STG NCT00694382 patients at risk Sanoﬁ-Aventis Beng Chong of venous thromboembolism (VTE) of VTE in cancer patients at high risk for VTE and who are undergoing chemotherapy.

An adaptive, comparative, randomized, parallel-group, multi-center, Phase Ib study of subcutaneous (SC) rituximab 2010-021380- SAWYER BO25341 versus intravenous (IV) rituximab CLL Roche Xavier Badoux 32 both in combination with chemotherapy (ﬂudarabine and cyclophosphamide), in patients with previously untreated CLL.

Pilot Study into the safety and ***Thrombo- efﬁcacy of thromboprophaxis and Cancer prophylaxis in treatment of thromboembolism NA Haematology In-HOUSE STG Shir-jing Ho Haematology in patients with haematological Patients Patients malignancies

Triple Therapy for Primary immune ***TT4-ITP01 NA ITP In-HOUSE STG Philip Choi Thrombocytopenia (ITP)

157 OTHER RESEARCH PROJECTS IN PROGRESS.

Vascular Biology: BH Chong, LM Khachigian, CR Parish, RO Stocker.

Drug-induced immune thrombocytopenia: BH Chong, M Davenport, J Perdomo, F Yan, XM Jiang, Z Ahmedi, P Choi, M Iraqi

Heparin-induced thrombocytopenia and thrombosis: Better understanding of pathogenesis and improving diagnosis and treatment. BH Chong, J Perdomo, F Yan, XM Jiang, Z Ahmedi, P Choi, Z Y New.

Sumoylaton and biology of FOG-2, a cardiac transcription factor: BH Chong, J Perdomo, F Yan, XM Jiang.

Sumoylaton and biology of GATA-1, an oncogene and haematopoiesis transcription factor: BH Chong, J Perdomo, F Yan, XM Jiang.

Gene regulation of platelet production: BH Chong, J Perdomo, F Yan, XM Jiang, S Liang, Shen-yi Liu.

Guidelines for Venous Thomboembolism (VTE) prevention in Hospitalised Medical Patients: N Chapman, M Lassere, M Clarke, BH Chong.

An audit to determine the incidence of Venous Thromboembolism (VTE) risk assessment and prophylaxis at regional and teaching hospitals in Australia. B Josephs, Chapman, N. BH Chong.

Understanding Hospital Admission Processes in respect to consideration of venous thromboembolism risk assessment. B Josephs, J Johnson, N Chapman, BH Chong.

Venous thromboembolism in Chronic Cardiac Failure and Respiratory Failure: Incidence and prevention in the community. N Chapman, Janet Newton, Nick Spilioppoulos, Carl Bryant, J Moses, S Lindstrom, BH Chong.

Study of venous thromboembolism risk assessment and prophylaxis implementation in surgical patients. J Aitken, N Chapman, Deb Cansdell, Suzy Davis, BH Chong.

158 ORIGINAL PEER-REVIEWED PUBLICATIONS

Chong BH 2010-2011

Wang B, Chen JB, Santiago FS, Janes M, Kavurma MM, Chong BH, Pimanda JE, Khachigian LM. Phosphorylation and Acetylation of Histone H3 and Autoregulation by Early Growth Response 1 Mediate Interleukin 1 beta Induction of Early Growth Response 1 Transcription. Arteriosclerosis Thrombosis and Vascular Biology. 30(3): 536-545, 2010.

Liang SX, Tan TJ, Chong BH. Differentiation and migration of Sca-1+/CD31- cardiac side population cells in a murine myocardial ischemic model. International J Cardiology. 138: 40-49, 2010.

Kidson-Gerber GL, Weaver J, Prasan A, Gemmell R, Chong BH. Serum Thromboxane B2 compared to ﬁve other platelet function tests for the evaluation of aspirin effect in stable cardiovascular disease. Heart, Lung and Circulation. Heart, Lung and Circulation. 2010; 19:234-242.

Hull RD, Schellong SM, Tapson VF, Monreal M, Samama MM, Nicol P, Vicaut E, Turpie AG, Yusen RD, and Collaborators including Chong B. EXCLAIM (Extended Prophylaxis for Venous ThromboEmbolism in Acutely Ill Medical Patients With Prolonged Immobilization) study. Extended-duration venous thromboembolism prophylaxis in acutely ill medical patients with recently reduced mobility: a randomized trial. Ann Intern Med. 2010; 153(1):8-18.

Bauersachs R, Berkowitz SD, Brenner B, Buller HR, Decousus H, Gallus AS, Lensing AW, Misselwitz F, Prins MH, Raskob GE, Segers A, Verhamme P, Wells P, Agnelli G, Bounameaux H, Cohen A, Davidson BL, Piovella F, Schellong S. EINSTEIN Investigators including Chong B. Oral rivaroxaban for symptomatic venous thromboembolism. N Engl J Med. 2010; 363(26):2499-510.

Ye JY, Chan GC, Qiao L, Lian Q, Meng FY, Luo XQ, Khachigian LM, Ma M, Deng R, Chen JL, Chong BH, Yang M. Platelet-derived growth factor enhances platelet recovery in a radiation- induced thrombocytopenic mouse model and reduces apoptosis in megakaryocytes via its receptors and PI3-k/Akt pathway. Haematologica. 2010; 95(10):1745-53.

Liang SX, Khachigian LM, Parish CR, Chong BH. Drug-induced thrombocytopenia (DITP): Development of a novel NOD/SCID mouse model to evaluate clearance of circulating platelets. Blood. 2010; 11 6(11):1958-60.

Kuter DJ, Rummel M, Boccia R, Macik BG, Pabinger I, Selleslag D, Rodeghiero F, Chong BH, Wang X, P. Berger DP. Romiplostim or Standard of Care in Patients with Immune Thrombocytopenia. N Engl J Med. 2010; 363(20):1889-99.

Liu C, Li J, Meng FY, Liang SX, Deng R, Li CK, Pong NH, Lau CP, Cheng SW, Ye JY, Chen JL, Yang ST, Yan H, Chen S, Chong BH, Yang M. Polysaccharides from the root of Angelica sinensis promotes hematopoiesis and thrombopoiesis through the PI3K/AKT pathway. BMC Complement Altern Med 2010; Dec 21; 10: 79

159 Lassen MR, Gallus A, Raskob GE, Pineo G, Chen D, Ramirez LM and Advance-3 Investigators including Chong BH,.Apixaban versus enoxaparin for thromboprophylaxis after hip replacement. N Engl J Med 2010; 363(26):2487-98.

Perdomo J, Fock EL, Kaur G, Yan F, Khachigian LM, Jans DA, Chong BH. A monopartite Sequence is essential for p45 NF-E2 nuclear translocation, transcriptional activity and platelet production. J Thromb Haemost. 2010 8(11):2542-53.

Chong BH, Gan E, Bird R, Pidcock M, Lloyd J, Tay L, Baker R, Stone C, Maher D. An open- label, multicenter study evaluating the efﬁcacy and safety of a new 10% liquid intravenous immunoglobulin (Intragam® 10 NF) in patients with primary immune thrombocytopenia (ITP). Asia-Paciﬁc J Oncol Hematol 2010, 2 (2): 7-12.

Chong BH, JJH Chong. Heparin-induced thrombocytopenia associated with fondaparinux. Clinical Advances in Hematology and Oncology. 2010: 8(1): 63-65.

Hicks C, Isaacs A, Wong R, Chong BH. CXCR4 expression on transplanted peripheral blood CD34 (+) cells: relationship to engraftment after autologous transplantation in a cohort of multiple myeloma patients. Ann Hematol. 2011; 90(5):547-55

Decousus H, Tapson VF, Bergmann JF, Chong BH, Froehlich JB, Kakkar AK, Merli GJ, Monreal M, Nakamura M, Pavanello R, Pini M, Piovella F, Spencer FA, Spyropoulos AC, Turpie AG, Zotz RB, Fitzgerald G, Anderson FA; IMPROVE Investigators. Chest. 2011; 139(1): 69-79.

Spyropoulos A, Anderson F, FitzGerald G, Décousus H,Pini M, Chong B, Zotz R, Tapson V, Froehlich J, Monreal M, Merli G, Pavanello R, Turpie A,Nakamura M,Piovella F, Kakkar A, Spencer F, Bergmann JF. Predictive and Associative Models to Identify Hospitalized Medical Patients at Risk for Venous Thromboembolism. Chest. 2011 Sep;140(3):706-14.102.

Equinox Investigators. Büller HR, Destors JM, Gallus A, Prins MH, Raskob G, CharbonnierDecousus H, Leizorovicz A, Laporte S, Prins MH, Brandjes DP, Middeldorp S, Destors JM, Pillion G, Ceresetto JM, Hendler H, Xavier DL, Santini F, del Carmen Gallo, Coughlin P, Chong B, et al. Efﬁcacy and safety of once weekly subcutaneous idrabiotaparinux in the treatment of patients with symptomatic deep venous thrombosis. J Thromb Haemost. 2011; 9(1):92-9.

Chen JB, Liu M, Parish CR, Chong BH, Khachigian LM. Nuclear import of early growth response-1 involves importin-7 and the novel nuclear localization signal serine-proline-serine. Int J Biochem Cell Biology. 2011; 43(6):905-12.

Perdomo J,Yan F, Ahmadi Z, Jiang XM, Stocker R, Chong BH. Quinine-induced thrombocytopenia: drug-dependent GPIb/IX antibodies inhibit megakaryocyte and proplatelet production in vitro. Blood 2011; 117 : 5975-5986.

Liang S, Khachigian L, Ahmadi Z, Mo Y, Lui S, Chong BH. In vitro and in vivo proliferation, differentiation and migration of cardiac endothelial progenitor cells (SCA1+/CD31+side population cells. J Thromb Haemostas. 2011; 9:1628-1637.

160 Heng LL, Caguioa P, Ng SC, Chiou T-J, Lee JW, Miyakawa Y, Tambunan Kl, Chong BH. Chronic Adult Primary Immune Thrombocytopenia (ITP) in the Asia-Paciﬁc Region. Int J Haematol. 2011; 94:142-149.

Chapman NH, Lazar SP, Fry M, Lassere MN, Chong BH. Clinicians adopting evidence based guidelines: a case study with thromboprophylaxis. BMC Health Services Research. 11: 240, 2011

F Roncolato - Publications - 2010 1. Piccaluga, P. P., Gazzola, A., Mannu, C., Agostinelli, C., Bacci, F., Sabattini, E., Sagramoso, C., Piva, R., Roncolato, F., Inghirami, G., & A., P. S. Pathobiology of Anaplastic Large Cell Lymphoma. Advances in Hematology, (2010): 2010:345053.

F Roncolato - Publications - 2011 1. Brennan, S., & Roncolato, F. Novel ﬁbrinogen (B 401GlyVal) presents as dys- or hypodysﬁbrinogenaemia due to alterations in sialic acid content. Thrombosis and Haemostasis (2011):106/3 (Sep) pp. 389–565), 551-553.

2. Piccaluga, P., Gazzola, A., Mannu, C., Agostinelli, C., Bacci, F., Sabattini, E., Sagramoso, C., Piva, R., Roncolato, F., Inghirami, G., & Pileri, S. (2011). Pathobiology of anaplastic large cell lymphoma. Adv Hematol. 2010:345053. Epub 2011 Feb 6.

3. Roncolato, F., Gazzola, A., Zinzani, P. L., Pileri, S. A., & Piccaluga, P. P. (2011). Targeted molecular therapy in peripheral T-cell lymphomas. [doi: 10.1586/ehm.11.55]. Expert Review of Hematology, 4(5), 551-562.

S Lee - Publication - 2010 1. Patton, N., Brown, G., Leung, M., Bavishi, K., Taylor, J., Lloyd, J., Lee, S. H., Tay, L., & Worthley, S. (2010). Observational study of iron overload as assessed by magnetic resonance imaging in an adult population of transfusion-dependent patients with thalassaemia: signiﬁcant association between low cardiac T2* < 10 ms and cardiac events. Internal Medicine Journal, 40(6), 419-426.

S Lee - Publication - 2011 1. Jou, J. M., Lewis, S. M., Briggs, C., Lee, S. H., De La Salle, B., McFadden, S., & For The International Council For Standardization In, H. (2011). ICSH review of the measurement of the erythocyte sedimentation rate. International Journal of Laboratory Hematology, 33(2), 125-132.

2. Zini, G., d’Onofrio, G., Briggs, C., Erber, W., Jou, J. M., Lee, S. H., McFadden, S., Vives-Corrons, J. L., Yutaka, N., & Lesesve, J. F. (2011). ICSH recommendations for identiﬁcation, diagnostic value, and quantitation of schistocytes. International Journal of Laboratory Hematology, 34(2), 107-116

161 X Badoux - Publications - 2010 1. Al-Ameri, A. A.-A., Kantarjian, H., Malik, A., Badoux, X., Andreeff, M., Quintas-Cardama, A., & Borthakur, G. (2010). Decitabine and Gemtuzumab Ozogamicin In Patients with Advanced Myeloﬁbrosis. ASH Annual Meeting Abstracts, 116(21), 5061-.

2. Al-Ameri, A. M., Badoux, X., Ferrajoli, A., Wierda, W. G., Fayad, L., Estrov, Z., Bickel, S., Keating, M. J., & O’Brien, S. (2010). Phase II Study of Dasatinib In Patients with Relapsed Chronic Lymphocytic Leukemia. ASH Annual Meeting Abstracts, 116(21), 4488-.

3. Al-Ameri, A. M., Cortes, J. E., Kantarjian, H., Burton, E., Quintas-Cardama, A., Jabbour, E., Badoux, X., O’Brien, S., & Mattiuzzi, G. (2010). Infectious Events In Patients with Chronic Myeloid Leukemia Treated with Nilotinib as a Front Line Therapy and After Imatinib Failure. ASH Annual Meeting Abstracts, 116(21), 1233-.

4. Badoux, X., Al-Ameri, A. M., O’Brien, S., Wierda, W. G., Burger, J. A., Faderl, S., Estrov, Z., Lerner, S., Keating, M. J., & Ferrajoli, A. (2010). Retrospective Analysis of the Experience with Rituximab and Methylprednisone In Elderly Patients with CLL. ASH Annual Meeting Abstracts, 116(21), 4636-.

5. Badoux, X., O’Brien, S., Wierda, W. G., Faderl, S., Estrov, Z., Yerrow, K., Kantarjian, H. M., Keating, M. J., & Ferrajoli, A. (2010). Combination of Ofatumumab and Lenalidomide In Patients with Relapsed Chronic Lymphocytic Leukemia: Initial Results of a Phase II Trial. ASH Annual Meeting Abstracts, 116(21), 2464-.

6. Badoux, X., Wierda, W. G., O’Brien, S. M., Faderl, S., Estrov, Z., Yerrow, K. A., Keating, M. J., & Ferrajoli, A. (2010). A phase II study of lenalidomide as initial treatment of elderly patients with chronic lymphocytic leukemia. ASCO Meeting Abstracts, 28(15_suppl), 6508.

7. Ferrajoli, A., Badoux, X., O’Brien, S., Wierda, W. G., Faderl, S., Estrov, Z., Pasia, M., Lerner, S., Kantarjian, H., & Keating, M. J. (2010). The Combination of Lenalidomide and Rituximab Induces Complete and Partial Responses In Patients with Relapsed and Refractory Chronic Lymphocytic Leukemia. ASH Annual Meeting Abstracts, 116(21), 1395-.

8. Parikh, S. A., Wierda, W. G., Badoux, X., O’Brien, S. M., Ferrajoli, A., Faderl, S., Burger, J. A., Lerner, S., Kantarjian, H., & Keating, M. J. (2010). Comparison of ﬂudarabine (F) plus cyclophosphamide (C) versus FC plus rituximab (R) in previously untreated Rai stage III/IV chronic lymphocytic leukemia (CLL). ASCO Meeting Abstracts, 28(15_suppl), 6519.

9. Tsimberidou, A. M., Wierda, W. G., Badoux, X., Wen, S., Plunkett, W., O’Brien, S. M., Kipps, T. J., Jones, J. A., Kantarjian, H., & Keating, M. J. (2010). Evaluation of oxaliplatin, ﬂudarabine, cytarabine, and rituximab (OFAR) combination therapy in aggressive chronic lymphocytic leukemia (CLL) and Richter’s syndrome (RS). ASCO Meeting Abstracts, 28(15_suppl), 6521.

162 X Badoux - Publications - 2011 Badoux, X., Bueso-Ramos, C., Harris, D., Li, P., Liu, Z., Burger, J., O’Brien, S., Ferrajoli, A., Keating, M. J., & Estrov, Z. (2011). Cross-talk between chronic lymphocytic leukemia cells and bone marrow endothelial cells: role of signal transducer and activator of transcription 3. [Research Support, Non- U.S. Gov’t]. Human pathology, 42(12), 1989-2000.

Badoux, X. C., Keating, M. J., O’Brien, S., Wierda, W. G., Faderl, S., Estrov, Z., Pasia, M., Lerner, S., Sargent, R. L., Kantarjian, H. M., & Ferrajoli, A. (2011). Final Analysis of a Phase 2 Study of Lenalidomide and Rituximab in Patients with Relapsed or Refractory Chronic Lymphocytic Leukemia (CLL). ASH Annual Meeting Abstracts, 118(21), 980-

Badoux, X. C., Keating, M. J., Wang, X., O’Brien, S. M., Ferrajoli, A., Faderl, S., Burger, J., Koller, C., Lerner, S., Kantarjian, H., & Wierda, W. G. (2011a). Cyclophosphamide, ﬂudarabine, alemtuzumab, and rituximab as salvage therapy for heavily pretreated patients with chronic lymphocytic leukemia. [Clinical Trial, Phase II Comparative Study Research Support, Non-U.S. Gov’t]. Blood, 118(8), 2085-2093.

Badoux, X. C., Keating, M. J., Wang, X., O’Brien, S. M., Ferrajoli, A., Faderl, S., Burger, J., Koller, C., Lerner, S., Kantarjian, H., & Wierda, W. G. (2011b). Fludarabine, cyclophosphamide, and rituximab chemoimmunotherapy is highly effective treatment for relapsed patients with CLL. [Clinical Trial, Phase II]. Blood, 117(11), 3016-3024.

Badoux, X. C., Keating, M. J., Wen, S., Lee, B. N., Sivina, M., Reuben, J., Wierda, W. G., O’Brien, S. M., Faderl, S., Kornblau, S. M., Burger, J. A., & Ferrajoli, A. (2011). Lenalidomide as initial therapy of elderly patients with chronic lymphocytic leukemia. [Clinical Trial, Phase II]. Blood, 118(13), 3489-3498.

Badoux, X. C., Keating, M. J., & Wierda, W. G. (2011). What is the best frontline therapy for patients with CLL and 17p deletion? [Review]. Current hematologic malignancy reports, 6(1), 36-46.

Ferrajoli, A., O’Brien, S., Wierda, W. G., Faderl, S., Badoux, X., Estrov, Z., Schlette, E., Smith, S. C., Ayala, A. B., Falchi, L., Calin, S., Kantarjian, H. M., & Keating, M. J. (2011). Combination Therapy with Ofatumumab and Lenalidomide in Patients with Relapsed Chronic Lymphocytic Leukemia (CLL): Results of a Phase II Trial. ASH Annual Meeting Abstracts, 118(21), 1788-

Lee, B. N., Gao, H., Cohen, E. N., Badoux, X., Wierda, W. G., Estrov, Z., Faderl, S. H., Keating, M. J., Ferrajoli, A., & Reuben, J. M. (2011). Treatment with lenalidomide modulates T-cell immunophenotype and cytokine production in patients with chronic lymphocytic leukemia. [Research Support, Non-U.S. Gov’t]. Cancer, 117(17), 3999-4008.

Parikh, S. A., Keating, M. J., O’Brien, S., Wang, X., Ferrajoli, A., Faderl, S., Burger, J., Koller, C., Estrov, Z., Badoux, X., Lerner, S., & Wierda, W. G. (2011). Frontline chemoimmunotherapy with ﬂudarabine, cyclophosphamide, alemtuzumab, and rituximab for high-risk chronic lymphocytic leukemia. [Clinical Trial, Phase II Research Support, Non-U.S. Gov’t]. Blood, 118(8), 2062-2068.

163 OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

Chong BH, JJH Chong. IVIg immune inhibitory activity: APC is key. Blood. 2010; 115(9): 1663-4.

Chong BH. ITP: Tregs come to the rescue. Blood. 2010; 116(22):4388-90.

Provan D, Stasi R, Newland AC, Blanchette VS, Bolton-Maggs P, Bussel JB, Chong BH, et al. International consensus report on the investigation and management of primary immune Blood. 2010; 115(2): 168-86.

Chong BH, Carrie van der Weyden. Deep vein thrombosis and pulmonary embolism, in Disease Index (Fifth Edition) Ed: Worth O, MIMS Australia, 2011.

Fletcher J, MacLellan D, Baker R, Chong BH, Fisher C, Flanagan D, Gallus A, Gibbs H, Matthews G, Salam H, Stacey M and van Rij A. Anticoagulant therapy in venous thromboembolism and atrial ﬁbrillation. Health Education and Management Innovations (ISBN 97809578909 6 1), Sydney 5th Edition 2011.

McNeil C, Fletcher J, MacLellan D, Baker R, Chong BH, Fisher C, Flanagan D, Gallus A, Gibbs H, Matthews G, Salam H, Stacey M and van Rij. A Prophylaxis and treatment of venous thromboembolism in patients with cancer. Health Education and Management Innovations. Sydney, 1st Edition. 2011.

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

B Chong - Conference/Symposia/Invited Lectureship – 2010- 2011

Chong BH. Eltrombopag, Impact of New Thrombopoietin Paradigm - Future Perspectives for ITP Management (Invited Lecture). Integrated Korean Haematology Society Annual Meeting May 27- 29, 2010. Seoul, Korea.

Chong BH. Future Perspectives in the Management of Chronic ITP. (Invited Lecture) 6th of Asia Paciﬁc Society on Thrombosis and Haemostasis, Bali, Indonesia. 13th-16th October, 2010.

Chong BH. Platelet functions and their assessment in Myelo-proliferative Neoplasms. (Invited Lecture) 13th ASEAN Conference of Clinical Laboratory Scientists Conference, 24-26 September 2010, Kuala Lumpur, Malaysia.

Chong BH. “WHO Classiﬁcation for Myeloproliferative Neoplasm ) and Its Implications”.(Invited Lecture). 13th ASEAN Conference of Clinical Laboratory Scientists Conference, 24-26 September 2010, Kuala Lumpur, Malaysia.

164 Chong BH. New Approaches to Management of Primary Immune Thrombocytopenia (ITP)”(Keynote lecture) Thailand ITP Symposium,Bangkok, July 21st, 2010

Chong BH. International ITP registry (Invited lecture). Thailand ITP Symposium, Bangkok, July 21st, 2010.

Chong BH. New Approaches to Management of Primary Immune Thrombocytopenia (Invited lecture).Phramongkut Hospital Haematology Symposium, Bangkok, 22nd July, 2010.

Chong BH. Future Perspectives in the Management of Chronic ITP (Invited lecture). Asia-Paciﬁc Society of Thrombosis and Haemostasis, Bali, Indonesia, October 13-16, 2010.

Chong BH. “Primary ITP in Adult”(Invited lecture). American Society of Hematology, Orlando, USA. December 4-7, 2010. Intercontinental cooperative ITP study group satellite meeting.

Chapman, N., Lassere, M., Clarke, M., & Chong, B. (2010). Guidelines for Venous Thomboembolism (VTE) prevention in Hospitalised Medical Patients: A Validation Pilot Study. Paper presented at the Annual Meeting of the Australasian Society of Thrombosis and Haemostasis.

Josephs, B., Chapman, N., & Chong, B. (2010). An audit to determine the incidence of Venous Thromboembolism (VTE) risk assessment and prophylaxis at a regional hospital in Australia. Paper presented at the Annual Meeting of the Australasian Society of Thrombosis and Haemostasis.

Josephs, B., Chapman, N., Chong, B., & Johnson, J. (2010). Understanding Hospital Admission Processes in respect to consideration of venous thromboembolism risk assessment. Paper presented at the Annual Meeting of the Australasian Society of Thrombosis and Haemostasis.

Chong BH. New Advances in the Treatment of ITP. (Invited lecture).Taiwan Haematology Society Annual Meeting Taipei, April, 2011

Chong BH. “Future perspectives in ITP Management” Corporate ITP Symposium, held in conjunction with Taiwan Society of Haematology meeting.

Chong BH. Update on VTE in Asia-Paciﬁc (Invited lecture) XXIII The International Society on Thrombosis and Haemostasis. 57th Annual SSC Meeting. Kyoto Japan July 23-28, 2011. Special symposium, entitled “Toward Better Anticoagulant Management: Experience and evidence with enoxaparin”.

Chong BH. An Overview of Management of Essential Thrombocythemia (invited lecture). Myeloproliferative Neoplasma Sympoisum, Feb 11-12, 2011. Sydney.

Chong BH. Afternoon thrombocytopenia. (Invited lecture). Haematology Society of Australia (NSW Branch) meeting, March 24, Sydney:

Chong BH. Understanding Disease Mechanisms is the key to better treatment of immune Thrombocytopenia. Australian Vascular Biology Society Annual Scientiﬁc Meeting, September 15- 18, 2011, Boral, NSW.

165 Chong BH. HIT and MIST: Fog has lifted on platelets. Barry Firkin Oration –Australasian Society of Thrombosis and Haemostasis, annual meeting October 28-Nov 2, Sydney 2011

Chong BH. TPO receptor agonist treatment in ITP: Australian experience. (invited lecture).Australia NZ Haematology Society of Australia National annual meeting October 28-Nov 2, Sydney 2011.

2010-2011 SH Lee

Parth Nanavati, Rema Nasr, Karen Staff, Sudha Pillai, Szu-Hee Lee. The Addition of Albumin To EDTA Blood Samples With Chronic Lymphocytic Leukaemia Enables The Recovery of Automated Lymphocyte Counts In The Sysmex Xe-2100 Autoanalyser. Int J Lab Hematol. 2010. 32:86 (abstract)

Patricia Pillai, Peter Loizou, Shazia Haque, Szu-Hee Lee. The Effect of a “Zero Tolerance” Policy and Educational Intervention on Sample Collection Errors in Blood Transfusion Practice. Abstract presented at the HAA, Auckland, NZ, Oct 2010.

Szu-Hee Lee, Steve Clark, Nathan Crettenden, Fiﬁn Intan, Katherine Marsden. An Evaluation Of The Online Display Of X100 Virtual Slides For Haematology Morphology Training. Int. Jnl. Lab. Hem. 2011. 33:112. (abstract)

John B Porter, Mohsen Elalfy, Yesim Aydinok, Lee Lee Chan, Szu-Hee Lee, Pranee Sutcharitchan, Ali Taher, Dany Habr, Bernard Roubert and Amal El-Beshlawy. Efﬁcacy And Safety Of Deferasirox In Patients With -Thalassaemia And Baseline Liver Iron Concentration <7 Or ≥7 Mg Fe/G Dw: Results From The Epic Liver Mri Substudy. 12th International Conference on Thalassaemia and Hemoglobinopathies. Antalya, Turkey, May 2011

Szu-Hee Lee, Steve Clark, Fiﬁn Intan, Nathan Crettenden, Katherine Marsden. The Online Display of Virtual Haematology Slides for Morphology Training: A Pilot Survey. Abstract presented at the HAA- ISHAPD, Sydney, Oct 2011.

2010 - N Chapman

1. Chapman, N., Lassere, M., Clarke, M., & Chong, B. (2010). Guidelines for Venous Thomboembolism (VTE) prevention in Hospitalised Medical Patients: A Validation Pilot Study. Paper presented at the Annual Meeting of the Australasian Society of Thrombosis and Haemostasis.

2. Josephs, B., Chapman, N., & Chong, B. (2010). An audit to determine the incidence of Venous Thromboembolism (VTE) risk assessment and prophylaxis at a regional hospital in Australia. Paper presented at the Annual Meeting of the Australasian Society of Thrombosis and Haemostasis.

3. Josephs, B., Chapman, N., Chong, B., & Johnson, J. (2010). Understanding Hospital Admission Processes in respect to consideration of venous thromboembolism risk assessment. Paper presented at the Annual Meeting of the Australasian Society of Thrombosis and Haemostasis.

166 S Ho - Conference - 2010 1. Cavanaugh, L., Gemmell, R., & Ho, S. (2010). Comparison of two different plastic sodium citrate tubes and their affect on routine coagulation results. Paper presented at the HAA

R Ristuccia - Conference - 2010 1. Ristuccia, R. (2010a). Clinical Trials Management Software - InfoEd Central Network Cancer Services - Pilot Site Experiences. Paper presented at the The St George & Sutherland Medical Research Symposium.

2. Ristuccia, R. (2010b). Clinical Trials Management System - Experiences of a Pilot Site. Paper presented at the HAA 2010 Auckland 17-20 October 2010

Other Group Projects

1. José Perdomo, Feng Yan, Zohra Ahmadi, Xing-Mai Jiang, Roland Stocker and Beng H. Chong. Proplatelet Production Is Impaired by Drug-Induced Thrombocytopenia Antibodies. Paper presented at American Hematological Society, Orlando, Florida, Dec 2010.

2. Jose Perdomo and Beng H. Chong (invited lecture). SUMOylation and Transcriptional Regulation, 2010, School of Biomedical Sciences, University of Newcastle, Australia

3. Feng Yan, José Perdomo, Shu Pan, Lacey Johnson, Beng Hock Chong. Enhanced Megakaryocytopoiesis and Thrombopoiesis by Mouse Megakaryocytic Progenitor Cells Over- expressing the Transcription Factor GATA-1: Paper presented at Haematology Society of Australia and New Zealand, the Australian & New Zealand Society of Blood Transfusion and the Australasian Society of Thrombosis and HaemostasisConference-ISHAPD, 2011, Sydney, Australia.

4. José Perdomo, Feng Yan, Zohra Ahmadi, Xing-Mai Jiang, Roland Stocker and Beng H. Chong. Anti-platelet Antibodies Induce Apoptosis, Inhibit Megakaryocyte Maturation and impair Pro- platelet Production, Paper presented at Haematology Society of Australia and New Zealand, the Australian & New Zealand Society of Blood Transfusion and the Australasian Society of Thrombosis and HaemostasisConference-ISHAPD, 2011, Sydney, Australia

5. Siong Meng Lim, José Perdomo, Peter Galettis and Matthew Links Antiangiogenic effect of low-dose paclitaxel is mediated by RhoA inactivation: A potential new mechanism. Paper presented at Proceedings of the AACR-NCI-EORTC International Conference: Molecular Targets and Cancer Therapeutics; 2011, San Francisco, CA.

6. José Perdomo, Feng Yan, Zohra Ahmadi, Xing-Mai Jiang, Roland Stocker and Beng H. Chong. Quinine-induced Thrombocytopenia: Drug-dependent Antibodies Inhibit Megakaryocyte and Proplatelet Production. Paper presented at XXIII Congress of the International Society of Thrombosis and Haemostasis, 2011, Japan

167 7. Jaa Yien New, Jose Perdomo, Xing-Mai Jiang and Beng Hock Chong. Heparin-Induced Thrombocytopenia and Thrombosis - A New Emerging Therapeutic Strategy. Paper presented at XXIII Congress of the International Society of Thrombosis and Haemostasis, 2011, Japan

8. Jaa Yien New, Jose Perdomo, Xing-Mai Jiang and Beng Hock Chong. Heparin-Induced Thrombocytopenia and Thrombosis – Therapeutic Strategy using a Single-Chain Variable Fragment Antibody (scFv). Paper presented at The St George & Sutherland Medical Symposium, Kogarah, 2011

9. Jaa Yien New, Jose Perdomo, Xing-Mai Jiang and Beng Hock Chong. Heparin-Induced Thrombocytopenia and Thrombosis- A New Emerging Therapeutic Strategy. Paper presented at Haematology Society of Australia and New Zealand, the Australian & New Zealand Society of Blood Transfusion and the Australasian Society of Thrombosis and Haemostasis Conference-ISHAPD, 2011, Sydney, Australia

COMMUNITY ENGAGEMENT

Awards - B Chong 2010-2011 1. Chong, B. Australasian Society of Thrombosis and Haemostasis, The Barry Firkin’s Oration award. 2. Chong, B. Research Award from Peoples’ Republic of China to BH Chong for his contributions to development of research and technology in Zhejiang Province, PR of China. 3. Chong, B. Royal College of Pathologists of Australasia South-East Asia Visiting Lecturer/Professor Award.

X Badoux - Award 2011 Badoux, X. Celgene - Future Leaders in Hematology Award for signiﬁcant contributions in the ﬁeld of hematology.

168 CANCER CARE DEPARTMENT OF MEDICAL ONCOLOGY

DEPARTMENTAL STAFF*

Head of Department Dr Kiran Prabhakar Phadke MB CHB FRCPA FRACP

Staff Specialists Dr Patricia Bastick MB BS BMedSc FRACP Grad Cert Epidemiology Conjoint Associate Lecturer UNSW

Dr Chee Khoon Lee MB BS MMedSc (Clinical Epidemiology) FRACP Mbiostats PhD Candidate

Associate Professor Winston Liauw MB BS MMedSc FRACP GAICD Graduate Certiﬁcate Politics & Policy

Conjoint Associate Professor Matthew Jon Links MB BS FRACP PhD

Dr Jodi Lynch MB BS FRACP

Dr David Thomas MB BS FRACP

Research Staff Clinical Trials Unit Peter Fink BSc - Manager Trials Coordinator Antoinette Fontela BSc Mary Margaret Gozar PhD Tracy Liaw PhD Stephen Millard CNS Shu Pan BSc Penny Taylor CNS Lisa Wang MSc Rhona Maclean BSc (Pharmacy)– Clinical Trials Pharmacist Research Administration Jane Hagin Jessica Ristuccia

169 RESEARCH GRANTS#

Category I - Nationally Competitive Grants: Source Principal investigators Project title Total awarded; years funded (eg $400,000; 2010 - 2012)

Category II - Other competitive grants: NSW Cancer Institute Associate Professor Matthew Links Cancer Trials Nurses and Data Manager’s Grant 2010/11 $248,040

Category III – Industry and other research funding: None reported

RESEARCH PROJECTS IN PROGRESS

Trial Tumour Principal Trial Short Name Clinical Trials Conducted Sponsor Registration # Grouping Investigator

Tamoxifen for 5 years vs. Toremifene for 5 years with or without chemotherapy as adjuvant therapy IBCSG 12-93 NCT00002529 Breast IBCSG Paul de Souza for post/perimenopausal, node positive, hormone receptor positive breast cancer patients.

Adjuvant Therapy for Postmenopausal Patients with Operable Breast Cancer who have Estrogen Receptor or Progesteron IBCSG/ IBCSG 13-93 NCT00004205 Breast Paul de Souza Receptor Positive Tumors Tamoxifen Novartis vs. Letrozole vs. Tamoxifen followed by Letrozole vs. Letrozole followed by Tamoxifen.

Phase III randomised, multi-centre, international trial to determine the relation between dose and clinical ACTRN Gastro- activity of STI—571 in patients GLIVEC 0126050 intestinal - AGITG Matthew Links with unresectable or metastatic 00138684 Stromal malignant gastrointestinal stromal tumors expressing the c—kit receptor tyrosine kinase (CD117)

Randomized phase III trial comparing docetaxel in combination with doxorubicin and cyclophosphamide Aventis (fmrly (TAC) versus doxorubicin and BCIRG 005 NCT00312208 Breast Breast Cancer Matthew Links cyclophosphamide followed by International) docetaxel (AC->T) as adjuvant treatment of operable breast cancer HER2neu negative patients with positive axillary lymph nodes

170 Trial Tumour Principal Trial Short Name Clinical Trials Conducted Sponsor Registration # Grouping Investigator

Multicenter Phase Iii Randomized Trial Comparing Doxorubicin And Cyclophosphamide Followed By Docetaxel (Ac T) With Doxorubicin And Cyclophosphamide Followed By Docetaxel And Trastuzumab Breast Cancer BCIRG 006 (Herceptin®) (Ac Th) And With NCT00021255 Breast Matthew Links International Docetaxel, Carboplatin And Trastuzumab (Tch) In The Adjuvant Treatment Of Node Positive And High Risk Node Negative Patients With Operable Breast Cancer Containing The Her2 Alteration.

Bristol Myers CARBO/TAX: Wkly Carboplatin + Squibb/ Taxol and Concomitant RT for locally Respiratory - CARBOTAX St. George Matthew Links advanced NSCLC: Predictors of Rx Lung (NSCLC) Hospital Tolerance. Matthew Links

A phase III trial evaluating the role of ovarian function suppression and the role of exemestane as adjuvant SOFT NCT00066690 Breast ANZBCTG Dr. Jodi Lynch therapies for premenopausal women with endocrine responsive breast cancer.

A Phase III, Randomized, Open- Label, Multicenter Study Comparing GW572016 and Capecitabine GlaxoSmith EGF 100151 NCT00078572 Breast Dr. Jodi Lynch (XELODA) Versus Capecitabine in Kline Women With Refractory Advanced or Metastatic Breast Cancer

A randomised phase II/III study design to evaluate the role of MAX Mitomycin C, Avastin and Xeloda in NCT00294359 Colorectal AGITG Winston Liauw patients with metastatic colorectal cancer.

A Phase III Trial Comparing GV1001 and Gemcitabine in Sequential Gastro- Pharmaxa / PRIMOVAX Combination to Gemcitabine NCT00358566 intestinal - Winston Liauw Orion Monotherapy in Advanced Un- Pancreas resectable Pancreatic Cancer.

An intergroup phase III trial to evaluate the activity of Docetaxel, given either sequentially or in combination with Doxorubicin, BIG 2 followed by CMF, in comparison to NCT00005659 Breast - Breast ANZBCTG Paul de Souza Doxorubicin alone or in combination with Cyclophosphamide, followed by CMF, in the adjuvant treatment of node positive breast cancer

Phase II, multi-center, two-stage study utilising a randomised discontinuation design to evaluate Urogenital - GlaxoSmith VEG102616 the safety and efﬁcacy of GW786034 NCT00244764 Paul de Souza Kidney Kline in adult subjects with locally recurrent or metastatic clear-cell Renal Cell Carcinoma (RCC).

171 Trial Tumour Principal Trial Short Name Clinical Trials Conducted Sponsor Registration # Grouping Investigator

Phase ll trial pf Patupilone plus prednisone versus Docetaxel EPO906 2229 Urogenital- plus prednisone in patients with NCT00411528 Novartis Paul de Souza Patupilone prostate metastatic hormone refractory prostate cancer

A Phase lll randomized, double- blind, multi-centre, parallel-group to assess the efﬁcacy of ZD6474 (ZACTIMA) versus Erlotinib Zactima (TARCEVA) in patients with locally NCT00364351 Lung Astra Zeneca Matthew Links advanced or metastatic (Stage 111B-lV) non-small cell lung cancer (NSCLC) after failure of at least one prior cytotoxic chemotherpay

A randomized, double-blind, muliti- centre, placebo-controlled study Glaxco-Smith TEACH of Adjuvant Lapatanib in women NCT00374322 Breast Jodi Lycnh and Klein with early stage breast ErbB2 overexpressing breast cancer.

A phase 1b/2 study of AMG655 in combination with Paclitaxel Respiratory- Paul De AMG655 and Carboplatin for the ﬁrst line NCT00534027 AMGEN Lung (NSCLC) Souza treatment of Advanced Non Small Cell Lung Cancer

CRAD001C2325: A randomised, double blind, placebo controlled, multi centre phase III study in CRAD001 patients with advanced carcinoid NCT00412061 Carcinoid Novartis Winston Liauw tumour receiving Sandostatin LAR® and RAD001 10mg/d or Sandostatin LAR® and placebo.

A randomised comparative study of FOLFOX 6m plus SIR-Spheres ACTRN versus FOLFOX6m alone as ﬁrst line SIRFLOX 1260600 Colorectal SIRTEX Winston Liauw treatment in patients with non- 0153516 resectable liver metastases from primary Colorectal Carcinoma.

A Phase 1 study of RAD001 (everolimus) in combination with Paul De RAD001 Solid Tumours Novartis ﬂuvastin and zoledronic acid in Souza patients with solid tumours.

A Randomized Trial of Temsirolimus and Sorafenib as Second-Line Paul De Torisel 404 Therapy in Patients With Advanced NCT00474786 Renal Cell Wyeth Souza Renal Cell Carcinoma Who Have Failed First-Line Sunitinib Therapy.

A Randomised, Double-blind, Multicentre Phase III Study to Compare the Efficacy of AZD2171 in Combination with 5-fluorouracil, Leucovorin, and Oxaliplatin AstraZeneca HORIZON III NCT00384176 Colorectal Winston Liauw (FOLFOX), to the Efficacy of / quintile Bevacizumab in Combination with FOLFOX in Patients with Previously Untreated Metastatic Colorectal Cancer.

172 Trial Tumour Principal Trial Short Name Clinical Trials Conducted Sponsor Registration # Grouping Investigator

A phase III randomized study of brivanib alaninate (bms-582664) in combination with cetuximab (erbitux®) versus placebo in ACTRN CO20 combination with cetuximab 1260700 Colorectal NHMRC Winston Liauw (erbitux®) in patients previously 0589482 treated with combination chemotherapy for metastatic colorectal carcinoma.

A Phase 1/11A Multiple Ascending dose study of BMS-777607 in CA192-002 NCT00605618 Solid Tumour BMS Paul de Souza subjects with advanced or metastatic solid tumours.

Study VEG108844, a Study of Pazopanib versus Sunitinib in the ACTRN Renal Cell COMPARZ Treatment of Subjects with Locally 1260900 GSK Paul de Souza Cancer Advanced and/or Metastatic Renal 0392268 Cell Carcinoma

A phase II Biomarker Identiﬁcation Trial for Erlotinib (Tarceva®) in Pancreatic MARKS 0804-045M Roche Winston Liauw Patient with advanced Pancreatic Cancer Carcinoma

Prediction of cardiotoxicity by measurement of serum N-terminal Royal Prince CATS pro-B-type natriuretic peptide in NCT00858039 Breast Jodi Lynch Alfred Hospital breast cancer patients receiving adjuvant trastuzumab.

A phase I, open- label, cohort study of multiple doses of Cavataktm (coxsackievirus a21) given CAVATAK NCT00636558 Solid Tumour Viralytics Winston Liauw intravenously to stage iv solid tumour cancer patients bearing icam-1 with or without daf expressing tumours.

A Prospective, Randomised, Double- Blind, Placebo-Controlled Phase III Study of Modaﬁnil to Improve Breast, MOTIF Fatigue and Quality of Life in Patients NCT00917748 Sanoﬁ-aventis Paul de Souza Prostate Treated with Docetaxel-Based Chemotherapy for Metastatic Breast or Prostate Cancer.

A Multicenter Phase III Randomized Trial of Adjuvant Therapy for Patients with HER2-Positive Node-Positive or High Risk Node-Negative Breast BETH NCT00625898 Breast Roche Jodi Lynch Cancer Comparing Chemotherapy Plus Trastuzumab with Chemotherapy Plus Trastuzumab Plus Bevacizumab

Patient views on the Assessing patient views on the University of quality of cancer Various Chee Lee quality of cancer care Newcastle care

A Randomized, Multicenter, Open- Label Phase 3 Study of Pemetrexed- Cisplatin Chemotherapy Plus IMC- 11F8 Versus Pemetrexed-Cisplatin INSPIRE NCT00982111 Lung Imclone Matthew Links Chemotherapy Alone in the First-Line Treatment of Patients With Nonsquamous Stage IIIb or IV Non- Small Cell Lung Cancer (NSCLC)

173 Trial Tumour Principal Trial Short Name Clinical Trials Conducted Sponsor Registration # Grouping Investigator

A Randomized, Multicenter, Open-Label, Phase 3 Study of Gemcitabine-Cisplatin Chemotherapy Plus Necitumumab SQUIRE (IMC-11F8) Versus Gemcitabine- NCT00981058 Lung Imclone Matthew Links Cisplatin Chemotherapy Alone in the First- Line Treatment of Patients With Stage IV Squamous Non-Small Cell Lung Cancer (NSCLC)

A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase 3 Study of Denosumab as D-CARE NCT01077154 Breast Amgen Jodi Lynch Adjuvant Treatment for Women with Early-Stage Breast Cancer at High Risk of Recurrence (D-CARE)

Multicenter Phase III Randomized Trial Comparing Doxorubicin And Cyclophosphamide Followed By Docetaxel (AC®T) With Doxorubicin And Cyclophosphamide Followed By Docetaxel And Trastuzumab BCIRG 006 Sub (Herceptin®) (AC®TH) And With NCT00021255 Breast Sanoﬁ Aventis Matthew Links study Docetaxel, Carboplatin And Trastuzumab (TCH) In The Adjuvant Treatment Of Node Positive And High Risk Node Negative Patients With Operable Breast Cancer Containing The Her2 Alteration. Breast Cancer Recurrence Substudy

A Pilot study of sleep disturbance in University of Sleep Study All types Matthew Links people with cancer Sydney

Randomized, Double-Blind, Phase 3 Trial to Compare the Efﬁcacy of Ipilimumab vs Placebo Patricia CA184095 in Asymptomatic or Minimally NCT01057810 Prostate BMS Bastick Symptomatic Patients with Metastatic Chemotherapy-Naïve Castration Resistant Prostate Cancer

A Randomized, Multicenter, Double-Blind, Placebo-Controlled Phase 3 Study of Weekly Paclitaxel With or Without Ramucirumab Rainbow (IMC-1121B) Drug Product in NCT01170663 Gastric Imclone Winston Liauw Patients With Metastatic Gastric Adenocarcinoma, Refractory to or Progressive After First-Line Therapy With Platinum and Fluoropyrimidine

A Double Blind Placebo Controlled Randomized Trial Of PF-804 In Patients with Incurable Stage IIIb/IV BR.26 NCT01000025 Lung NCIC Matthew Links Non-Small Cell Lung Cancer After Failure Of Standard Therapy For Advanced Or Metastatic Disease

The Utility Of Genomics And Functional Imaging To Predict ACTRN Peter Predict IR Irinotecan Pharmacokinetics And 1261000 Colorectal Winston Liauw MacCallum Pharmacodynamics: The Predict IR 0898055 Study

174 Trial Tumour Principal Trial Short Name Clinical Trials Conducted Sponsor Registration # Grouping Investigator

A Phase 3, Randomized, Double- Blinded, Placebo-Controlled Study Of ARQ 197 Plus Erlotinib Versus Placebo Plus Erlotinib In Previously Daiichi Marquee NCT01244191 Lung Matthew Links Treated Subjects With Locally Sankyo Advanced Or Metastatic, Non- Squamous, Non–Smallcell Lung Cancer (NSCLC)

A randomized Phase III, double- blind, placebo-controlled multicenter trial of daily everolimus in combination with trastuzumab and Patricia Bolero 3 NCT01007942 Breast Novartis vinorelbine, in pretreated women Bastick with HER2/neu over-expressing locally advanced or metastatic breast cancer

A Multi-Centre Study of Tamoxifen Sydney West Dose Escalation Study in Breast Tade NCT01075802 Breast Area Health Jodi Lynch Cancer Patients with CYP2D6 Service Polymorphisms

ORIGINAL PEER-REVIEWED PUBLICATIONS

Abdul MIM, Jiang X, Williams KM, Day RO, Roufogalis BD, Liauw WS, Xu H, Matthias A, Lehmann RP, McLachlan AJ. Pharmacokinetic and pharmacodynamic interactions of echinacea and policosanol with warfarin in healthy subjects. British Journal of Clinical Pharmacology 2010;69:508-15.

Cao CQ, Yan TD, Bester L, Liauw W, Morris DL. Radioembolization with yttrium microspheres for neuroendocrine tumour liver metastases. British Journal of Surgery 2010;97:537-43.

Chua TC, Al-Alem I, Saxena A, Liauw W, Morris DL. Surgical cytoreduction and survival in appendiceal cancer peritoneal carcinomatosis: an evaluation of 46 consecutive patients. Ann Surg Oncol 2011;18:1540-6.

Chua TC, Al-Alem I, Zhao J, Glenn D, Liauw W, Morris DL. Radiofrequency Ablation of Concomitant and Recurrent Pulmonary Metastases after Surgery for Colorectal Liver Metastases. Ann Surg Oncol 2011.

Chua TC, Al-Zahrani A, Saxena A, et al. Determining the association between preoperative computed tomography ﬁndings and postoperative outcomes after cytoreductive surgery and perioperative intraperitoneal chemotherapy for pseudomyxoma peritonei. Ann Surg Oncol 2011;18:1582-9.

Chua TC, Al-Zahrani A, Saxena A, Liauw W, Zhao J, Morris DL. Secondary Cytoreduction and Perioperative Intraperitoneal Chemotherapy after Initial Debulking of Pseudomyxoma Peritonei: A Study of Timing and the Impact of Malignant Dedifferentiation. Journal of the American College of Surgeons 2010;211:526-35.

175 Chua TC, Chu F, Butler SP, Quinn RJ, Glenn D, Liauw W, Morris DL. Intra-arterial iodine-131-lipiodol for unresectable hepatocellular carcinoma. Cancer 2010;116:4069-77.

Chua TC, Liauw W, Koong HN, Esquivel J. Surgical therapies in metastatic colorectal cancer with a potential for cure. Am J Clin Oncol 2011;34:326-31.

Chua TC, Liauw W, Morris DL. Early recurrence of pseudomyxoma peritonei following treatment failure of cytoreductive surgery and perioperative intraperitoneal chemotherapy is indicative of a poor survival outcome. Int J Colorectal Dis 2011.

Chua TC, Liauw W, Robertson G, Morris DL. Second-line treatment of ﬁrst relapse recurrent ovarian cancer. Australian and New Zealand Journal of Obstetrics and Gynaecology 2010;50:465-71.

Chua TC, Liauw W, Saxena A, Al-Mohaimeed K, Fransi S, Zhao J, Morris DL. Evolution of locoregional treatment for peritoneal carcinomatosis: single-center experience of 308 procedures of cytoreductive surgery and perioperative intraperitoneal chemotherapy. American Journal of Surgery 2011;201:149-56.

Chua TC, Martin S, Saxena A, Liauw W, Yan TD, Zhao J, Lok I, Morris DL. Evaluation of the cost- effectiveness of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (peritonectomy) at the St George Hospital peritoneal surface malignancy program. Annals of Surgery 2010;251:323-9.

Chua TC, Morris DL, Saxena A, et al. Inﬂuence of modern systemic therapies as adjunct to cytoreduction and perioperative intraperitoneal chemotherapy for patients with colorectal peritoneal carcinomatosis: a multicenter study. Ann Surg Oncol 2011;18:1560-7.

Chua TC, Robertson G, Liauw W, Morris DL. Salvage cytoreduction for chemorefractory ovarian cancer with peritoneal carcinomatosis: A last chance or futile efforts? Australian and New Zealand Journal of Obstetrics and Gynaecology 2010;50:478-84.

Chua TC, Saxena A, Liauw W, Chu F, Morris DL. Hepatectomy and resection of concomitant extrahepatic disease for colorectal liver metastases - A systematic review. Eur J Cancer 2011.

Chua T, Saxena A, Chu F, Liauw W, Zhao J, Morris D. Clinicopathological Determinants of Survival After Hepatic Resection of Hepatocellular Carcinoma in 97 Patients—Experience From an Australian Hepatobiliary Unit. Journal of Gastrointestinal Surgery 2010;14:1370-80.

Chua TC, Saxena A, Liauw W, Chu F, Morris DL. Hepatic resection for metastatic breast cancer: A systematic review. Eur J Cancer 2011.

176 Chua TC, Saxena A, Liauw W, Kokandi A, Morris DL. Systematic review of randomized and nonrandomized trials of the clinical response and outcomes of neoadjuvant systemic chemotherapy for resectable colorectal liver metastases. Ann Surg Oncol 2010;17:492-501.

Chua TC, Saxena A, Schellekens JF, Liauw W, Yan TD, Fransi S, Zhao J, Morris DL. Morbidity and mortality outcomes of cytoreductive surgery and perioperative intraperitoneal chemotherapy at a single tertiary institution: towards a new perspective of this treatment. Ann Surg 2010;251:101-6.

Chua TC, Thornbury K, Saxena A, Liauw W, Glenn D, Zhao J, Morris DL. Radiofrequency ablation as an adjunct to systemic chemotherapy for colorectal pulmonary metastases. Cancer 2010;116:2106-14. de Souza PL, North S, Bolger GB, Spiridonidis H, Lim R, Khoo KS, Phillips J, Fujimori M. A phase II trial of weekly i.v. KW-2170 in advanced castrate-resistant prostate cancer. Asia-Paciﬁc Journal of Clinical Oncology 2010;6:292-7. de Souza PL, Russell PJ, Kearsley JH, Howes LG. Clinical pharmacology of isoﬂavones and its relevance for potential prevention of prostate cancer. Nutrition Reviews 2010;68:542-55.

Evans KA, Richardson MG, Pavlakis N, Morris DL, Liauw W, Bester L. Survival Outcomes of a Salvage Patient Population after Radioembolization of Hepatic Metastases with Yttrium-90 Microspheres. Journal of Vascular and Interventional Radiology 2010;21:1521-6.

Links M, Sargeant C, Waters A, Liauw W, Thomas P. Implementing a Multi-professional Web-based Learning Environment for a Comprehensive Cancer Centre: Obstacles, Solutions and Reﬂections. J Cancer Educ 2011.

Metharom E, Galettis P, Manners S, Jelinek M, Liauw W, de Souza PL, Hoskins JM, Links M. The pharmacological advantage of prolonged dose rate gemcitabine is restricted to patients with variant alleles of cytidine deaminase c.79A>C. Asia-Paciﬁc Journal of Clinical Oncology 2011;7:65-74.

Metharom E, Galettis P, Manners S, Links M. Modulation of Gemcitabine Accumulation by DNA- Damaging Agents: Mechanisms and Speciﬁcity in an In Vitro Model. Anticancer Research 2010;30:3669-73.

Pourgholami MH, Szwajcer M, Chin M, Liauw W, Seef J, Galettis P, Morris DL, Links M. Phase I clinical trial to determine maximum tolerated dose of oral albendazole in patients with advanced cancer. Cancer Chemother Pharmacology 2010;65:597–605.

6. Saxena A, Chua TC, Sarkar A, et al. Progression and survival results after radical hepatic metastasectomy of indolent advanced neuroendocrine neoplasms (NENs) supports an aggressive surgical approach. Surgery 2011;149:209-20.

Scott KF, Sajinovic M, Hein J, Nixdorf S, Galettis P, Liauw W, de Souza P, Dong Q, Graham GG, Russell PJ. Emerging roles for phospholipase A2 enzymes in cancer. Biochimie 2010;92:601-10. Tudor E, Chua T, Liauw W, Morris D. Risk factors and clinicopathological study of prognostic factors in the peritoneal mesothelioma. American Surgery 2010;76:400-5.

177 Worth LJ, Lingaratnam S, Taylor A, Hayward AM, Morrissey S, Cooney J, Bastick PA, Eek RW, Wei A, Thursky KA. Use of risk stratiﬁcation to guide ambulatory management of neutropenic fever. Internal Medicine Journal 41 (2011) 82-89 2011.

Yang S, de Souza P, Alemao E, Purvis J. Quality of life in patients with advanced renal cell carcinoma treated with temsirolimus or interferon-alfa. Br J Cancer 2010;102:1456-60.

OTHER PUBLISHED MATERIAL (BOOKS, BOOK CHAPTERS, REVIEWS,)

Day R, Liauw W, Tozer L, McElduff P, Beckett R, Williams K. A double-blind, placebo-controlled study of the short term effects of a spring water supplemented with magnesium bicarbonate on acid/ base balance, bone metabolism and cardiovascular risk factors in postmenopausal women. BMC Research Notes 2010;3:180.

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

Boyer M, Rischin D, Horwood K, Pavlakis N, de Souza P, Millward M, Stein B, Johnston M, Abell F. Efﬁcacy of erlotinib in patients with advanced non-small-cell lung cancer (NSCLC): Analysis of the Australian population of the TRUST study. MOGA. Sydney; 2010.

Clemons M, Gelmon K, Lynch J, Kotliar M, Joy A, Jordaan J, Han L, Blair J, Iscoe N. A double-blind, randomized, prospective, Phase II trial of capecitabine(Cap) plus enzastaurin(Enz) versus Cap plus placebo in patients (pts) with advanced breast cancer (BrCa) and prior anthracyclineand taxane treatment. ASCO. Chicago USA; 2010. de Souza P, Mellado B, Pﬁster C, Rosenthal M, Castellano D, Weber D, Ferrara S, Shaik N, Tan E, Patterson S. Phase II trial of patupilone plus prednisone versus docetaxel plus prednisone in patients with chemo-naïve, metastatic hormone-refractory prostate cancer (HRPC). ASCO (poster discussion). Chicago; 2010.

Lemech C, Cosman R, Lee C, Friedlander M, Lewis C, Lynch J, Thomas D, Clingan P, Glasgow A. Cardiac Dysfunction and Breast Cancer Recurrence in Patients Receiving Trastuzumab for Early Stage Breast Cancer in the SESIAHS network. MOGA. Sydney; 2010.

Lobb E, Lacey J, Kearsley J, Liauw W, Thomas D. A Study to Explore Factors Which Contribute to Coping with Uncertainty in Patients with Advanced Cancer. International Congress on Palliative Care, Palais des Congres Montreal, Canada; 2010.

178 Lobb E, Lacey J, Sanderson C, Connell S, Kearsley J, Thomas D. Identifying Strategies to Support Hope. International Congress on Palliative Care, Palais des Congres. Montreal, Canada; 2010.

Lynch J, Boyle F, Wilcken N, Hague C. Australian Breast Cancer Patients Enrolled in the Lapatinib Expanded Access Program (LEAP). MOGA. Sydney; 2010.

Goel S, Lynch J, Chantrill L, Rutovitz JJ, Murray B, Abdi E, Bell R, Sullivan A, Goldrick A, Hayes T, Asghari G, Wilcken N, McCarthy N, Beith J. Serum cardiac biomarkers and individual genetic polymorphisms as predictors of trastuzumab- related cardiotoxicity. ASCO. Chicago, USA; 2011.

COMMUNITY ENGAGEMENT

Associate Professor Winston Liauw is a member of the Scientiﬁc Advisory Board for ImPaCCT (Improving Palliative Care Through Clinical Trials) and PaCCSC (Palliative Care Clinical studies Collaborative), a director of NPS Better Choices - Better Health (the National Prescribing Service) and Chair of the Cancer Institute NSW Clinical Research Ethics Committee and the St George Hospital Ethics Committee.

179 CANCER CARE DEPARTMENT OF RADIATION ONCOLOGY

DEPARTMENTAL STAFF*

Head of Department Professor J H Kearsley MBBS (Hons Syd) FRACP FRANZCR PhD (Qld)

Senior Medical Staff (staff specialists) A/Professor Peter Graham MBBS, FRANZCR, Cert Bioethics, Grad Dip Medical Statistics Dr Joseph Bucci MBBS FRACP FRANZCR Dr Catherine Clark MBBS FRANZCR Dr Yaw Chin BSc (Med)FRANZCR

Junior Medical Staff 2010 Dr Nadine Beydoun Dr Megan Berry Dr Penny Magoulas Dr Annie Lee

Junior Medical Staff 2011 Dr Nadine Beydoun Dr Frederick Ho Dr Leily Gholamrezaei Dr Penny Magoulas Dr Hilde Kleiven

Research Staff Clinical Trials Unit Peter Fink, Clinical Trials Unit Manager –Radiation Oncology Trials Co-ordinators Helen Cox BSc Sima Don PhD Manuela Glinski-Smith BMedSci Jennifer Graham RN MN Kylie Melki - BBioTech Sharon Parkes BSc Xiaolu Wang MHealthAdmin Lydia Wong RN Xiaobing Ma BMed Rhona Maclean BSC(Pharmacy)

180 Senior Research Staff Dr Yong Li MBBS MSC PhD Dr Lois Browne BSc PhD GDipMedStats MMedStats (with merit) AStat Dr Raymond Clarke PhD Prof Barry Allen PhD DSc Professor Anatoly Rosenfeld PhD

Research Assistants Z M Fang

Research Students Julia Beretov: PhD student Jingjing You: PhD student Jingli Hao: PhD student Helen Hao: PhD student Crystal Semaan : PhD Weiwei Xiao: PhD student Srinivasa P Pothula PhD student Jie (Kevin) Ni, Master student Chen Hongmin, Visiting scientist Chen Hongtu, Visiting scientist

Administration Jane Hagin - Administration Ofﬁcer Kareen Fierro - Clinical Trials Assistant Megan Ristuccia Jessica Ristuccia

Radiation Therapy Research Staff Laurel Foessel BSc/Cert RT Stami Trakis BAppSc MRS Carolina Ragusa BAppSc MRS Alexander Podreka BAppSc MRS

Medical Physics Research Staff Brad Oborn Andrew Howie Kevin Loo (Ph D student)

181 RESEARCH GRANTS#

Category I - Nationally Competitive Grants:

NH&MRC Project Grant 454390 (2007-2011) Chief Investigators: A Prof B Chua, Prof S Fox, A Prof G Delaney, AProf M McKay, Dr P Schoﬁeld, A Prof I Campbell Associate Chief Investigators: Prof S Lakhani, Dr A Milner, A Prof P Graham Dr D Blakey, Dr J Harvey, A Prof D Christie, Dr E Millar. Project Title: A randomized phase III study of radiation dose and fractionation schedules in non low risk ductal carcinoma in situ (DCIS) of the breast. Amount: $1,648,750.

NH&MRC Career Development Fellow (Level 2): Chief Investigator: Li Y. Project Title: Identiﬁcation of novel biomarkers in urine to improve diagnosis and monitor progression in prostate cancer. Total awarded: $417,000 (2010-2014)

NH&MRC ID 1000557 Chief Investigators: Rozenfeld A, Bucci J, Lerch M, Petasecca M, Jakubeck J, Meikle S, Zaider M. Project Title: “BrachyVision: A novel multipurpose probe for in-body radiation imaging and dosimetry”. Total awarded: 2010- $176, 500., 2011- $100,000, 2012 - $166,500.

NH&MRC ID 573428 Chief Investigators: Rozenfeld A, Kron T, Conway M, Lerch M, Metcalfe P, Carolan M. Project Title: “High spatial resolution dosimetry for radioactive plaques used for radiotherapy for eye lesions”. Total awarded: 2009 - $139,750., 2010 - $119,750, 2011 $94,750.

NH&MRC Grant ID APP 1017394. Chief Investigators: Lerch M Rozenfeld A, Petasecca M, Guatelli S, Hauserman D, Bravin A, Hall C. Project Title: Radiosurgery with sub-millimeter x-ray beams: development of the X-tream real time monitoring and QA system. . Total awarded: $390,000. (2011-2013)

Cancer Australia (2010-2012) Project Grant 626201 Chief Investigators: Cls A/Prof P Graham, Prof G Delaney, Dr E Millar, Dr Anne Capp Als Prof R Sutherland, Dr S Carroll, Dr J Harvey, Dr J Lynch, Dr R Tse Project Title: TROG 08.06.

182 A Randomised comparison of anastrozole commenced before and continued during adjuvant radiotherapy for breast cancer versus anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy. (STARS – Study of Anastrozole and Radiotherapy Sequencing). Total awarded: $660,000.

Cancer Australia/National Breast Cancer Foundation Chief Investigators: Holloway L, Metcalfe P, Lazarus E, Delaney G, Batumalai V, Vial P, Koh E-S. Als: Quinn A, Jameson M, Hargreaves B, Moran C, Keall P, Collins L, Shaﬁq J, Rozenfeld A, Lonergan, Papadatos G, Lim K, Ahern V, Drummond R, Tlver, Graham P, Ramsay J. Project Title: Breast MRI in radiotherapy planning. Amount: $391.596. (2011)

Australian Research Council (ARC) - linkage. Chief Investigators: Li Y, Wilcox MD, Cozzi PJ, Russell PJ, Walsh BJ, Zhao Z. Project Title: Identiﬁcation of novel biomarkers in tears for prostate cancer diagnosis and prognosis. Total awarded: $586,000 (2007-2010).

Australian Research Council Chief Investigators: Rozenfeld A, Zaider M, Dzurak A, Jameson D, Lerch M, Guatelli S, Kuncik Z, Petasecca M, Reinhard M. Project Title: “Development of innovative radiation detectors and computational techniques for improving quality of life”. Total Awarded : 2010 - $100,000, 2011 - $100,000, 2012 - $100,000.

Australian Research Council/Linkage Projects Application LP110200467. Chief Investigators: Li Y, Graham P, Kearsley J, Walsh B. Zhao Z, Wilcox M. Project Title: “Proteomic study of tears to discover novel biomarkers for human breast cancer”. Amount: $152,000 (2011-2014)

Australian Research Council -Linkage Grant Award Chief Investigators: Li Y, Willcox MD, Cozzi PJ, Walsh BJ, Zhao Z. Project Title: Proteomic study of urine to discover novel biomarkers for human prostate cancer. Total awarded: $150,000 (2011-2014:)

Australian Research Council DP 110104007. Chief Investigators: Rozenfeld A, Petasecca M, Guatelli S, Metcalfe P, Jackson M, Carolan M. Project Title: Uniﬁed platform for real time QA in radiation therapy in brachytherapy basaed on high resolution silicon detectors. (Magic Plate). Total awarded: 2011 - $100,000., 2012 - $100,000, 2013 - $100,000.

183 Australian Research Council DP986055 Chief Investigator: Allen B. Project Title: Boron and gadolinium agents for boron neutron capture therapy. Total awarded: 2009-2011 - $410,000.

Category II - Other competitive grants:

Cancer Institute NSW Career Development Fellowship: Chief Investigator: Li Y. Project Title: Using proteomic approaches to identify novel biomarkers in tear and serum to improve diagnosis and monitor progression. Total awarded: $543,189 (2007-2010).

Cancer Institute NSW Research Innovation Grant reference 10/RFG/2-27. Project Title: Predicting dysphagia-related complications and improving outcomes in patients treated with head and neck radiotherapy. Cls Prof I Cook, Dr M Szczesniak, A/Prof P Graham, Ms J McLean, Dr R Gallagher. Als Ms H Brake, Dr L Browne, Dr R Jagavkar. Amount: $48,393.

Cancer Institute NSW Rozenfeld A. NSW Cancer Institute Academic Leadership Grant (Radiation Oncology-Medical Physics Chair, employed at CMRP Prof P Metcalfe). 2011-2015. Amount $1.3 M.

Cancer Institute NSW Early Career Development Fellowship Chief Investigator: Li Y. Project Title: Using proteomic approaches to identify novel biomarkers in tear and serum to improve diagnosis and monitor progression in prostate cancer. Total awarded: $125,000 (2007~2010)

UNSW Gold Star award Chief Investigator: Li Y. Project Title: Identiﬁcation of novel urinary biomarkers for prostate cancer Total Awarded: $40,000 (2010)

St George Medical Research Foundation Chief Investigator: Li Y. Project Title: CD44 and CD147 in prostate cancer metastasis and drug resistance. Total awarded: $50,000 (2010-2011.)

184 Clinical Trials Network Supported Studies (NSW Cancer Council / NSW Cancer Institute) Chief Investigator: P Graham Project Title: Breast STARS Pilot Randomised Controlled Trial

Charity Donation Chief Investigators: Li Y, Kearsley J. Project Project Title: Using a combination approach to control metastatic ovarian cancer in vitro and in vivo. Total awarded: $114,000 (2010-2012).

Category III – Industry and other research funding:

None reported.

RESEARCH PROJECTS IN PROGRESS

Topic: A randomised comparison of breast conservation with or without lumpectomy radiotherapy boost Principal Investigator: Associate Professor Peter Graham

Topic: A randomised trial investigating the effectiveness of different durations of maximal androgen deprivation prior to and during deﬁnitive radiation therapy for locally advanced carcinoma of the prostate. Principal Investigator: Professor John Kearsley

Topic: Pulmonary Fibrosis following breast conservation adjuvant radiotherapy: the modifying effects of systemic therapies (chemotherapy and tamoxifen) Principal Investigator: Associate Professor Peter Graham

Topic: A phase III study of regional RT in early breast cancer (NCIC MA20). Principal Investigator: Associate Professor Peter Graham

Topic: Randomised trial investigating the effect on survival and PSA control of different durations of adjuvant androgen deprivation in association with deﬁnitive radiation treatment for localised carcinoma of the prostate (RADAR). Principal Investigator: Dr Joseph Bucci

Topic: STARS Pilot Breast Trial: A randomised comparison of Anatrazole commenced before and continues during radiotherapy for breast cancer versus Anastrazole and subsequent Anti-Oestrogen therapy delayed until after radiotherapy Principal Investigator: Associate Professor Peter Graham

185 Topic: A collaborative randomised phase III trial: The timing of intervention with androgen deprivation in prostate cancer patients with a rising PSA. Principal Investigator: Dr Joseph Bucci

Topic: Prospective Outcomes-analyses for localised Prostate Adenocarcinoma after Radiotherapy Treatment Principal Investigator: Dr Joseph Bucci

Topic: A randomised phase III study of radiation doses and fractionation schedules in non-low risk ductal carcinoma in situ (DCIS) of the breast. Principal Investigator: Associate Professor Peter Graham Co-Investigator: Laurel Foessel.

Topic: A phase III multi-centre randomised trial comparing adjuvant radiotherapy (rt) with early salvage rt in patients with positive margins or extraprostatic disease following radical prostatectomy. Principal Investigator: Dr Joseph Bucci

Topic: Whole Brain Radiotherapy following local treatment of intracranial metastases of melanoma - A randomised phase III trial Principal Investigator: Associate Professor Peter Graham

Topic : A randomised comparison of Anastrozole commenced before and continued during adjuvant radiotherapy for breast cancer versus anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy (STARS). Principal Investigator: Associate Professor P Graham

Topic: Patient-reported Outcome Monitoring in Testicular Cancer Patients Principal Investigator: Dr J Bucci

Topic: Understanding the long-term psychosocial sequelae of surviving testicular cancer Principal Investigator: Dr Joseph Bucci

Topic: Determining the needs of Grade III-IV High Grade Glioma patients Principal Investigator: Professor John Kearsley

Topic: A randomised phase II/III trial of preoperative chemoradiotherapy versus preoperative chemotherapy for resectable gastric cancer Principal Investigator: Dr Yaw Chin

Topic: BrachyView: Development of in body imaging system for in vivo real time I-125 seed imaging in prostate during the seed implantation. Principal Investigators: Prof A Rozenfeld, CMRP and Prostate Cancer Institute, Dr J Bucci, Dr M Lerch, Dr Marco Petasecca, Dean Cutajar, PhD students: Kevin Loo,

186 Topic: Dosimetry system for eye plaques brachytherapy Principal Investigators: Prof A Rozenfeld, CMRP and Prostate Cancer Institute; Dr J Bucci, Dr Y Wong; Prof J Kearsley SG CCC and Prostate Cancer Institute

Topic: Real time urethral dosimetry system Principal Investigators: Prof A Rozenfeld, CMRP and Prostate Cancer Institute and Dr J Bucci, Dr Y Wong, Prof J Kearsley, STG CCC and Prostate Cancer Institute

Topic: Magic Plate: Development of 2D detector arrays for in vivo real time ﬂuence monitoring and in a phantom dose QA mentoring in IMRT and VMAT Principal Investigators: Prof A Rozenfeld, CMRP and Prostate Cancer Institute, CMRP:Prof P. Metcalfe, Dr M Lerch, Dr Marco Petasecca, Dr Dean Cutajar, PhD students: J. Wong, I. Fuduli, A.Espinoza,

Topic: In phantom QA for HDR brachytherapy. Principal Investigators: Prof A Rozenfeld, CMRP and Prostate Cancer Institute, CMRP:Dr M Lerch, Dr Marco Petasecca, Dr Dean Cutajar , POWH and CMRP: Dr Stephanie Corde PhD students: J Wong, I. Fuduli, A.Espinoza, MSc students: Brad

Topic: Identiﬁcation of novel biomarkers in urine to improve diagnosis and monitor progression in prostate cancer. NHMRC Career Development Fellow (Level 2) (2010~2014:$417,000) Principal Investigator: Li Y.

Topic: Proteomic study of urine to discover novel biomarkers for human prostate cancer. Principal Investigators: Li Y, Willcox MD, Cozzi PJ, Walsh BJ, Zhao Z.

Topic: Proteomic study of tears to discover novel biomarkers for human breast cancer. Principal Investigators: Li Y, Graham P, Walsh BJ, Zhao Z

Topic: Volumetric assessment of rectal ﬁlling inﬂuencing target volumes in radical post- prostatectomy radiotherapy. Principal Investigators: Dr Joseph Bucci, Alex Podreka.

Topic: Advanced Practice Techniques in CT-axial scanning/bolus tracking. Principal Investigators: Dr Yaw Chin, Carolina Ragusa.

Topic: Spacer and Focal Brachytherapy. Topic: Radiation Sensitivity. Investigator: Allen B.

187 ORIGINAL PEER-REVIEWED PUBLICATIONS

2010

Allen BJ, Rizvi SMA, Qu CF, Smith R. Targeted alpha therapy approach to the management of pancreatic cancer Dec 2010. Special issue: “Pancreatic Cancer” (http://www.mdpi.com/sio/cancers/pancreatic-cancer/)

Aslani A, Gill AJ, Roach PJ, Allen BJ, Smith RC. Preoperative body composition is inﬂuenced by the stage of operable pancreatic adenocarcinoma but does not predict survival after Whipple’s procedure. J Hepato-Pancreato-Biliary Association, 2010, 12, 325–333

Bräuer-Krisch E, Rosenfeld A, Lerch M, Petasecca M, Akselrod M, Sykora J, Bartz N, Ptaszkiewicz M, Olko P, Berg A, Wieland M, Doran S, Brochard T, Kamlowski A, Cellere G, Paccagnella A, Siegbahn EA, Prezado Y, Martinez-Rovira I, Bravin A, Dusseau L, Berkvens P. Potential High Resolution Dosimeters For MRT. AIP Conference Proceedings, July 23, 2010, Volume 1266, 89-97, 2010

Bug M, Gargioni E, Guatelli S, Incerti S, Rabus H, Schulte R, and Rosenfeld AB. Effect of a magnetic ﬁeld on the track structure of low-energy electrons: a Monte Carlo study, Euro Phys J D 2010: 60: 85-92.

Chen H, Wang L, Beretov J, Hao JL, Xiao W, Li Y. Co-expression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression. Clin Exp Metastas 2010;27: 557-569.

Clasie B, Wroe A, Kooy H, Depauw N, Flanz J, Paganetti H, Rosenfeld A. Assessment of out-of-ﬁeld absorbed dose and equivalent dose in proton ﬁelds. Med Phys, 2010: 37(1),311-321.

De Souza PL, Russell PJ, Kearsley JH, Howes LG. Clinical pharmacology of isoﬂavones and its relevance for the potential treatment of prostate cancer. Nutrition Reviews 68 (9) 2010: 542-555.

Fang ZM, Kozlov S, McKay MJ, Woods R, Birrel G, Sprung CN, Murrell D, Wangoo K, Teng L, Kearsley JH, Lavin MF, Graham PH, Clarke RA. Low levels of ATM in breast cancer patients with clinical radiosensitivity. Genome Integrity, 2010: 1 (9)

Early breast Cancer Triallists’ Collaborative Group (EBCTCG). (Graham P, Browne L.) Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. J Natl Cancer Inst Monogr 41, 2010: 162-177.

188 Fuks E, Horowitz YS, Horowitz A, Oster L, Marino S, Rainer M, Rosenfeld A and H. Datz. Thermoluminescence Solid-State nanodosimetry-the peak 5A/5 dosemeter. Rad Prot Dosim 2010 (Advance Access published December 13, 2010)

Graham PH. Faculty of Radiation Oncology Endorsed Guidelines for Informed Consent: risk description. J Med Imaging Radiat Oncol 2010: 54(5), 512.

Graham PH, Bucci J, Browne L. A randomised comparison of 20 Gy in 4 daily fractions versus 40 Gy in 20 bi-daily fractions for cerebral metastases. Int J Radiat Oncol Biol Phys 2010: 77 (3), 648-654.

Hao JL, Chen HM, Madigan MC, Cozzi PJ, Beretov J, Xiao W, Delprado WJ, Russell PJ, Li Y. Co-expression of CD147 (EMMPRIN), CD44v3-10, MDR1 and monocarboxylate transporters (MCTs) is related with prostate cancer drug resistance and progression. Br J Cancer 2010; 103:1008-1018.

Hao JL, Cozzi PJ, Khatri A, Power CA, Li Y. EMMPRIN/CD147 and CD44 are potential therapeutic targets for metastatic prostate cancer. Curr Cancer Drug Targ 2010; 20:287-306.

Hardcastle N, Cutajar D L, Metcalfe PE, Lerch MLF,. Perevertaylo VL, Tomé, WA Rosenfeld A. In vivo real-time rectal wall dosimetry for prostate radiotherapy. Phys Med Biol 2010: 55, 3859-3871.

Incerti S, Baldacchino G, Bernal, Capra R, Champion C, Francis Z, Guatelli S, Guèye P, Mantero A, Mascialino B, Moretto P, Nieminen P, Rosenfeld A, Villagrasa C and Zacharatou C. The Geant4-DNA project”, Int. J. Model Simul Sci Comput. 2010: 1, 157-178 .

Jakubek J, Pospisil S, Rosenfeld AB. Neutron dosimeter development based on MEDIPIX 2. IEEE Trans on Nucl Sci 2010: NS-57(6), 3456-3462.

Kabir NA, Harvey SB, Rosenfeld A. Design and fabrication of pulmonary embolism phantom for planar and SPECT V/Q imaging quality assurance. Australasian Physical & Engineering Sciences in Medicine, 2010: 33(3):271-277.

Kearsley JH. Therapeutic use of self and the relief of suffering. Cancer Forum 2010: 34,( 2)

189 Khatri A, Ho T, Lindholm L, Li Y, Russell PJ. Promise of BLCA38 as a targeting antibody for tissue-speciﬁc gene delivery to prostate cancer. Recent Adv Res Updates 2010;11: 143-151.

Li Y, Cozzi P, Madigan, MC, Kearsley JH, Russell P. Promising therapeutic targets for future prostate cancer therapy. Edited by Prof Malay Chatterjee et al. Bentham Science Publisher. Angiogenesis, Apoptosis and Therapeutic Targets in Cancer, 2010, 37-78.

Li Y, Cozzi PJ, Russell PJ. Promising tumor-associated antigens as potential therapeutic targets for future prostate cancer therapy. Med Res Rev 2010, 30:67-101.

Li Y, Cozzi PJ. Angiogenesis as a strategic target for prostate cancer therapy. Med Res Rev 2010, 30:23-66.

Li Y. Tear biomarkers for future prostate cancer diagnosis. J Open Biomarker 2010, 33-36.

Livingstone J, Horowitz YS, Oster L, Datz H, Lerch M, Rosenfeld A and Horowitz A. Experimental Investigation of the 100 keV X-ray Dose Response of the High Temperature Thermoluminescence in LiF:Mg,Ti (TLD-100): Theoretical Interpretation using the Uniﬁed Interaction Model. Rad Prot Dos, 2010, 138(4):320-33.

Oborn B, Metcalfe P, Butson M, Rosenfeld A. Monte Carlo Characterization of skin doses in transverse field MRI-Linac systems: Effect of field size, surface orientation, magnetic field strength, and exit bolus. Med Phys 2010, 37 (10), 5208-5217.

Othman MAR, Marinaro DG, Petasecca M, Guatelli S, Cutajar DL, Lerch MLF , Prokopovich DA, Reinhard MI, Uher J, Jakubek J, Pospisil S, Rosenfeld AB. From imaging to dosimetry:GEANT 4 based study on application of MEDIPIX to neutron dosimetry. Radiation Measurements, 2010, 45, 1355-1358.

Othman MAR, Cutajar DL, Hardcastle N, Guatelli S, Rosenfeld AB. Monte Carlo study of MOSFET packaging, optimized for improved energy response: Single MOSFET ﬁltration. Rad Prot Dos 2010, 141(1):10-17.

Othman MAR, Petasecca M, Guatelli S, Uher J, Marinaro DG, Prokopovich DA, Reinhard MI, Lerch MLF, Pisacane VL, Dolecek QE, Malak H, Cucinotta FA, Zaider M, Rosenfeld AB, Rusek A, Sivertz M and Dicello JF. Microdosimeter instrument (MIDN) for assessing risk in space. Rad Prot Dosim 2010, 143, No. 2–4, pp. 398–401.

190 Penfold S, Schulte R, Censor Y, Rosenfeld A. Total variation superiorization schemes in proton computed tomography image reconstruction. Med Phys 2010, 37(11), 5887-5895.

Prokopovich D, Reinhard M, Cornelius I, Rosenfeld A . GEANT4 Simulation of the CERN-EU High Energy Reference Field (CERF) Facility. Rad Prot Dos Rad Prot Dos 2010, 141(2), 106-113.

Sgouros G, Roeske JC, McDevitt MR, Palm S, Allen BJ,j Fisher DR, Brill AB, Song H, Howell RW, Akabani G. MIRD pamphlet No 22 (abridged): radiobiology and dosimetry of alpha-particle emittes for targeted radionuclide therapy. J Nuclear Medicine 2010, 51, 2: 311-328.

Weaver M, Green J, Petasecca M, Lerch MLF, Cutajar D, Franklin D, Jakubek J, Carolan MG,,Conway M, PospisilS, Krone T, Metcalfe P, Zaider M, Rosenfeld AB. Three-dimensional dosimetry imaging of I-125 plaque for eye cancer treatment”, Nucl Inst. Meth-A (on line 6 July 2010).

Wong J, Carolan M, Lerch M, Petasecca M, Khanna S, Perevertaylo V, Metcalfe P and Rosenfeld A. A Silicon Strip Detector Dose Magnifying Glass For IMRT Dosimetry. Med Phys 2010, 37(2),427-439.

You J, Cozzi P, Walsh B, Willcox M, Kearsley J, Russell P, Li Y. Innovative biomarkers for prostate cancer early diagnosis and progression. Critical Reviews in Oncology/Hematology 2010, 73, 10-22.

You J, Fitzgerald A, Cozzi PJ, Zhao Z, Graham P, Russell PJ, Walsh BJ, Willcox M, Zhong L, Wasinger V, Li Y. Post-translation modiﬁcation of proteins in the tear. Electrophoresis 2010, 31:1853-1861.

2011

Allen B, Singla A, Rizvi SA, Graham P, Bruchertseifer F, Apostolidis C. Analysis of patient survival in Phase 1 trial of Systemic Targeted alpha therapy for metastatic melanoma. Immunotherapy 2011, 3 (9), 1041-1050.

Allen BJ, Rizvi SMA, Qu CF, Smith R. Targeted alpha therapy approach to the management of pancreatic cancer. Cancers: Special issue: “Pancreatic Cancer” 2011, 3, 1821-1843

Allen BJ. Can alpha-radioimmunotherapy increase efﬁcacy for the systemic control of cancer? Immunotherapy 2011, 3(4), 301-304.

191 Allen BJ, Singla AA, Abbas Rizvi SM, Graham P, Bruchertseifer F , Apostolidis C, Morgenstern A. Analysis of Patient Survival in a Phase 1 Trial of Systemic Targeted Alpha Therapy for Metastatic Melanoma. Immunotherapy 2011, 3 (9), 1041-50

Allen BJ. Future Prospects for Targeted Alpha Therapy. In: Current Radiopharmaceuticals 2011, 4, 336-342.

Chen JY, Hruby G, Stockler MR, Patanjali N, Bucci J, Perez G, Loadsman JA, Sheehan E. Patient- reported outcomes of prostate high-dose-rate brachytherapy boost comparing an outpatient and inpatient protocol: a two-centre chronologic cohort study. Brachytherapy 10: 2011, 454-60.

Cullen A, Lerch M, Petasecca M, Rosenfeld A. Monte Carlo modelling of a silicon strip detector for microbeam radiation therapy. Radiation Measurements 2011, 46, 1646-1649.

Dicello JF , Pisacane VL, Dolecek QE, Rosenfeld AB, Rusek A, Sivertz M, Malak H. Feasibility study of solid-state microdosimetry for energetic protons and heavy ions with coincident particle identiﬁcation. Radiation Measurements, 2011, 46 ,1539-1542. Early Breast Cancer Trialists’ Collaborative Group (EBCTCG). (Graham P, Browne) Effect of radiotherapy after breast-conserving surgery on 10 year recurrence and 15 year breast cancer mortality: meta-analysis of individual patient data on 10,801 women in 17 randomised trials. Lancet 2011, 378(9804) 1707-1716.

Early Breast Cancer Trialists’ Collatborative Group (EBCTCG) (Graham P Browne L). Relevance of breast cancer hormone receptors and other factors to the efﬁcacy of adjuvant Tamoxifen: patient-level meta-analysis of randomised trials. Lancet 2011, 378, 1707-1716

Fuks E, Horowitz YS, Horowitz A, Oster L, Marino S, Rainer M, Rosenfeld A and Datz H. Thermoluminescence Solid-State nanodosimetry-the peak 5A/5 dosemeter. Rad Prot Dosim 2011, 143(2-4):416-26.

Graham P. Re: Panoff et al. Risk of loregional recurrence by receptor status in breast cancer patients receiving modern systemic therapy and post-mastectomy radiation. Br Cancer JRes Treat 2011, 130 (1), 353-4.

Hao J, Madigan M, Cozzi P, Kearsley JH, Li Y. Angiogenesis, Lymphangiogenesis and Vasculogenic Mimicry in Human Prostate Cancer Therapy. Advances in Medicine & Biology; 2011, Vol 38. Nova Science Publishers Inc.

Horowitz Y S, Fuks E, Datz H, Oster L, Livingstone J and Rosenfeld A. Mysteries of LiF TLD response following high ionisation density irradiation: nanodosimetry and track structure theory, dose response and glow curve shapes. Radiat Prot Dosim 2011, 145(4):356-72.

Horowitz YS, Siboni D, Oster L, Livingstone DJ, Guatelli S, Rosenfeld A, Emﬁetzoglou D, Bilski P and Obryk B. Alpha particle and proton relative thermoluminescence efﬁciency in LiF:Mg, Cu, P: is track structure theory up to the task? RadProt Dos 2011, doi:10.1093/rpd/ncr406.

192 Kearsley J. In the Night Time of Your Fear: the anatomy of compassion in the healing of the sick. Palliative & Supportive Care, 2011, 9(2), 215-221.

Kearsley JH. Rembrandt, Michelangelo, and Stories of Healing. Journal of Pain & Symptom Management, 2011, Vol 42: 5 Nov, 783-787.

Kearsley JH. Presence. Journal of Palliative Medicine 2011, 14 (12), 1350.

Kelly A, Hardcastle N, Metcalfe P, Cutajar D, Quinn A, Foo K, Cardoso M, Barlin S, Rosenfeld A. Surface dosimetry for breast radiotherapy in the presence of immobilisation cast material. Phys Med Biol 2011, 56,1001-1013.

Lerch MLF, Petasecca M, Cullen A, Hamad A, Requardt H, Brauer-Krisch E, Bravin A,.Pervertaylo VL, Rosenfeld AB. Dosimetry of Intensive Synchrotron Microbeams. Radiation Measurements, 2011, 46, 1560-1565.

Lian CPL, Othman MAR, Cutajar D, Butson M, Guatelli S, Rosenfeld AB. Monte Carlo study of the energy response and depth dose water equivalence of the MOSkin radiation dosimeter at clinical kilovoltage photon energies. Australas Phys Eng Sci Med, 2011, 34(2):273-9.

McGrath P and Kearsley JH. Caring for dying patients can be a satisfying experience. The Canadian Medical Association Journal, 183 (2), 2011: 169-170.

Millar EKA, Graham PH, McNeil CM, Browne O’Toole SA, Boulghourjian A, Kearsley JH, Papadatos G, Delaney G, Fox C, Nasser E, Capp A and Sutherland RL. Prediction of outcome of early ER+ breast cancer is improved using a biomarker panel, which includes Ki67 and p53. British Journal of Cancer, 105, 2011: 272-280.

Penfold SN, Rosenfeld AB, Schulte RW, Sadrozinski HFW. Geometrical optimization of aparticle tracking system for proton computed tomography. Radiation Measurements, 2011, 46, 2069-2072.

Pisacane V, Dolecek Q, Rosenfeld A, Malak H. Proton and Iron Observations from a Solid-State Microdosimeter. Rad Prot Dosim (published on line 7 December , 2011, 10.1093/rpd/ncr452.

193 Prokopovich D, Cornelius I, Reinhard M, Rosenfeld A. Response of PIN diode and SOI microdosimeter in the TSL quasi monoenergetic neutron ﬁeld. IEEE Trans Nucl Sci, 2011, Dec.

Qi ZY , Deng XW, Huang SM, Huang XY, He ZC, Lerch M, Metcalfe P, Rosenfeld A, Kron T. Real-Time In Vivo Dose Veriﬁcation for Serial Tomotherapy of Head and Neck Patients. Int J Radiation Oncology Biol Phys 2011, 80(5), 1581-1588.

Quinn A, Holloway L, Cutajar D, Hardcastle N, Rosenfeld A, Metcalfe P. Megavoltage cone beam CT near surface dose measurements: potential implications for breast radiotherapy. Med Phys, 2011, 38, N11, 6222

Tieu MT, Graham P, Browne L, Chin YS. The effect of adjuvant postmastectomy radiotherapy bolus technique on local recurrence. Int J Radiat Oncol Biol Phys 2011, 81 (3) e165-e171.

Wang L, Chen HM, Liu FH, Madigan MC, Hao JL, Power CA, Patterson KI, Pourgholami MH, O’Brien P, Perkins AC, Li Y. Monoclonal antibody targeting MUC1 and increasing sensitivity to docetaxel as a novel strategy in treating human epithelial ovarian cancer. Cancer Lett 2011;300:122-133.

Wang L, Chen HM, Pourgholami MH, Beretov J, Hao JL, Chao HT, Perkins AC, Kearsley JH, Li Y. Anti-MUC1 monoclonal antibody (C595) and docetaxel markedly reduce tumor burden and ascites, and prolong survival in an in vivo ovarian cancer model. Plos ONE 2011;6:e24405.

Weaver M, Petasecca M, Lerch MLF, Cutajar D, Jakubek J, Pospisil S, Rosenfeld AB. Dosimetry veriﬁcation in eye brachytherapy using silicon pixelated detectors. Radiation Measurements 2011, 46 (12) 2010-2013.

Wong JHD, Knittel T, Downes S , Carolan S ,Lerch M , Petasecca M , Khanna S , Peterevertaylo VL, Metcalfe P, Jackson M & Rosenfeld AB. Silicon strip detector dose magnifying glass on stereotactic radiotherapy QA and dosimetry. Med Phys 2011, 38 (3), 1226-1238.

Wong JHD , Hardcastle M, Tomé WA, Bayliss A , Tolakanahalli R, Lerch MLF, Petasecca M, Carolan M, Metcalfe P, and Rosenfeld AB. Independent quality assurance of a helical tomotherapy machine using the dose magnifying glass. Med Phys 2011, 38(4), 2256-2264 .

Wong JHD, Cutajar D, Lerch MLF , Petasecca M, Knittel T, Carolan M, Perevertaylo VL, Metcalfe P & Rosenfeld AB. From HEP to medical radiation dosimetry. Radiation Measurements, 2011, 46,1615-1618.

194 Xiao WW, Graham PH, Power CA, Hao J, Kearsley JH, Li Y. CD44 is a biomarker associated with human prostate cancer radiation sensitivity. Clinical & Experimental Metastasis, 2011, 29:1-9.

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

Allen BJ, O Rahman eds. Workshop on palliative radiotherapy for developing countries, Saigon 2008. Vivid Publishing 2010.

Allen BJ. Asia-Oceania Congress of Medical Physics.,IN Workshop on palliative radiotherapy for developing countries, Saigon 2008. Vivid Publishing 2010, 4-6.

Allen BJ. Health technology and training task group. Workshop on palliative radiotherapy for developing countries, Saigon 2008. Vivid Publishing, 2010, 7-8.

Allen BJ. Comparative cost analyses for Co-60 and linacs in developing countries, IN Workshop on palliative radiotherapy for developing countries, Saigon 2008. Vivid Publishing 2010, 124-126.

Graham PH. Reply to Davey et al. Randomized comparison of whole brain radiotherapy 20 Gy in 4 daily fractions versus 40 Gy in 20 bd fractions of brain metastases. Int J Radiat Oncol Biol Phys 78, 2010: 1606.

Marcu L, Bezak E, Allen BJ. Biomedical Physics in Radiotherapy for Cancer. Publisher CSIRO 2011, 431 pages.

Pathiraja V, Allen BJ. Achieving improved health care through telemedicine, IN Workshop on palliative radiotherapy for developing countries, Saigon 2008. Vivid Publishing 2010, 116-117.

Rosenfeld AB, Kron T, d’Errico F and Moscovitch M editors. Concepts and trends in medical radiation dosimetry. American Institute of Physics Conference Proceedings 1345 – ISBN:978-0-7354-0901-9 (2011)

195 Shortt K, Allen BJ. Appropriate technology for palliative radiotherapy, IN Workshop on palliative radiotherapy for developing countries, Saigon 2008. Vivid Publishing 2010, 9-13.

Xiao W, Graham P, Power C, Li Y. Biomarkers for radiosensitivity and radiosensitization targets in prostate cancer, IN : Oncoproteins: Types and Detections. Nova Science Publishers Inc, Hauppauge NY 11788; ed: Susan D Nguyen. 2010: 190-228. ISBN 978- 1-61761-986-1.

Issued patents A B Rozenfeld, M.Zaider “Method and apparatus for real time dosimetry”, United States Divisional Patent Application No. 12/050469, successful (Filling day 03/18/2008), approved March 2011.

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

Graham P, Browne L, Capp A, Fox C, Delaney G, Kearsley J, Millar EK, Nasser E, Papadatos G. Randomized trial shows reduced whole breast dose negates beneﬁt of lumpectomy radiotherapy boost. Radioth Oncol 96 (Suppl 1): S145, 2010. 29th ESTRO Barcelona 12-16 September 2010.

Group EBCTC, Australia CSGHS, Browne L, Graham P. Overview of the randomized trials of radiotherapy in ductal carcinoma in situ of the breast. JNCI Monographs 2010: 16277.

Hau E, Browne LH, Cail S, Chin , Clark C, Inder S, Khanna S, Szwajcer A, Graham PH. Boost with reduced breast dose is associated with improved cosmesis: results of a randomized trial. Radioth Oncol 96 (Suppl 1): S19, 2010. 29th ESTRO Barcelona 12-16 September 2010.

Huang CY, Guatelli S, Oborn BM, Allen BJ. Background Dose for systemic Targeted Alpha Therapy. Joint International Conference on Supercomputing in Nuclear Applications and Monte Carlo 2010 (SNA + MC2010) Tokyo, Japan, October 27-21, 2010.

Kearsley J H. Rembrandt, Michelangelo & Stories of Healing. 18th International Congress on Palliative Care, Montreal, Canada: October 2010.

196 Lobb E, Lacey J, Sanderson C, Brennan F, Connell S, Calvary Health Care Sydney; Kearsley J, Thomas D, St George Hospital. Identifying Strategies to Support Hope, International Congress on Palliative Care, Palais des Congress Montreal Canada: October 2010.

Lobb E, Lacey J, Kearsley J, Liauw W, Thomas D. A study to explore Cactors which Contribute to Coping with Uncertainty in Patients with Advanced Cancer. International Congress on Palliative Care, Palais des Congress Montreal, Canada, 2010.

Li Y. Using proteomic approaches to identify potential biomarkers for prostate cancer in tears and serum. BIT’s 3rd Annual World Cancer Congress, 22-25 June, Singapore. 2010

Li Y, Hao JL, Cozzi PJ, Kearsley JH (2010). CD44 and CD147 in prostate cancer metastasis and chemoresistance. Sixth International Symposium on Hormonal Oncogenesis, 12-16 September, Tokyo, Japan.

Li Y, Cozzi PJ, Power CA, Russell PJ, Allen BJ, Kearsley JH. Inhibition of micrometastatic prostate cancer cell spread in animal models by biolabeled multiple targeted radioimmunoconjugates. Innovative Minds in Prostate Cancer Today (MpaCT). Submitted, Orlando USA 2010.

Rosenfeld A. Invited talk - Solid State Micro and Nano dosimetry and its applications Radiation Damage in Biomolecular Systems (RADAM 2010), 30th June -4th July Madrid, Spain, 2010

Rosenfeld A. Invited Seminar. Advanced Semiconductor Dosimetry in Radiation Therapy: new concepts, development and applications. Department of Human Oncology and Medical Physics, Wisconsin University Hospital, USA 2010.

Rosenfeld A, Ziebell A, Petasecca M, Lerch M et al. Silicon PIN structures for Radiation Field Diagnostic in Hadron Therapy. IEEE Nuclear Science Symposium and Medical Imaging Conference, October 27th-1st , November, Knoxville, USA 2010.

Rosenfeld A. Keynote Talk. Progress in Silicon Microdosimetry. The 9th Annual Meeting of Japanese Association of Radiation Safety Management, December 1st-3rd , 2010, Hiroshima University, Japan

Trakis, S. Addressing the challenges of planning and contouring patients for the STARS trial. TROG, Auckland NZ, 2010.

197 International

2011

Beretov J, Graham P, Kearsley J, Li Y. The HDAC inhibitor panobinostat (LBH589) signiﬁcantly enhances radiotherapy effect in breast cancer cell lines. European Institute of Oncology-13th Milan Breast Cancer Conference, Italy, 22-24 June 2011.

Hao JL, Madigan MC, Khatri A, Power CA, Hung TT, Beretov J, Xiao W, Cozzi PJ, Kearsley J, Li Y. CD44 and CD147 confer metastasis and chemoresistance potential on prostate cancer in vitro and in vivo. Montreal International Symposium on Angiogenesis and Metastasis (MISAM), Montreal, Canada, 15-17 June 2011

Lerch MLF, Petasecca M, Cullen A, Requardt H, Brauer-Krisch E, Bravin A, Pervertaylo VL, Kryukov A, Rosenfeld AB. High Resolution Detectors used for Real-Time Dosimetry in Microbeam Radiation Therapy. IEEE Nuclear Science and Medical Imaging Conference Spain, 2011.

Loo K, Petasecca M, Safavi M, Han Z, Lerch M, Pospisil S, Jakubek J, Meikle S, Zaider M, Bucci J, Rosenfeld A. BrachyView: In-Body Imagins System for Prostate Brachytherapy. IEEE Nuclear Science and Medical Imaging Conference Spain, 2011.

Millar EKA, Graham P, O’Toole S, Browne L, Boulqourjian A, McNeil C, Kearsley J, Papadatos G, Delaney G, Fox C, Nasser E, Capp A, Sutherland RL. Prediction of outcome of early ER+ breast cancer is improved using a biomarker panel which includes Ki-67 and p53. 13 Milan Breast Cancer Conference 22-24 June 2011.

Rosenfeld A (invited talk). Real Time Semiconductor Dosimetry. 2nd Workshop: Hadron Beam Therapy of Cancer, Erice-Sicily, Italy 20-27 May 2011.

Rosenfeld (Invited Special Lecture). Progress in semiconductor dosimetry for radiotherapy, diagnostic radiology and radiation protection. The 7th International Workshop on Ionizing Radiation Monitoring, Oarai, Japan, December 2011.

Safavi-Naeini M, Franklin DR, Lerch M, Petaecca M, Moorhead G, Kirkham R, Dunn P, O’Keefe G, De Geronimo G, Rosenfeld AB. Preclinical studies using a Protype High-resolution PET Sydney with Depth of Interaction. IEEE Nuclear Science and Medical Imaging Conference Spain, 2011.

198 Weaver, M, Petasecca M, Cutajar D, Lerch M, Perevertaylo V, Kryukov A, Conway M, De Geronimo, G, Pospisil S, Rosenfeld AB. New dosimetric 3D quality assurance system for eye brachytherapy. IEEE Nuclear Science and Medical Imaging Conference Spain, 2011.

National

2010

Cutajar D, Hardcastle N, Bucci J, Miller S, Chambers R, Rosenfeld A. Real Time Dosimetry Of The Rectal Wall During Hdr Brachytherapy. Australian Brachytherapy Conference (ABG 2010) , Melbourne , 2010

Hao JL, Madigan MC, Cozzi PJ, Khatri A, Power CA, Beretov J, Kearsley J, Li Y (2010). CD44 and CD147 expression inﬂuence prostate cancer chemoresistance and metastasis. The Australian Society for Medical Research (ASMR), 7 June, Sydney Australia.

Hao JL, Madigan MC, Cozzi PJ, Khatri A, Power CA, Beretov J, Kearsley J, Li Y (2010). The St George and Sutherland Hospital Medical Research Symposium, 30 September.

Hao JL, Madigan MC, Cozzi PJ, Khatri A, Power CA, Kearsley J, Li Y (2010). CD44 and CD147 expression inﬂuences prostate cancer chemoresistance and metastasis. Australian Association of Chinese Biomedical Scientists (AACBS), Sydney, 24 October 2010.

Kearsley J, Lacey J, Lobb E, Liauw W, Thomas D, Whie LE, Hosie A. A study to explore factors which contribute to coping with uncertainty in patients with advanced cancer. COSA Melbourne, November 2010.

Weaver M, Green J, Cutajar D, Petasecca M, Franklin D, Jakubek J, Lerch MLF, Carolan MG, Conway M, Pospisil S, Kron T, Metcalfe P, Zaider M, Rosenfeld AB. Dose Imaging With Silicon Pixilated Detectors For I-125 And Ru-106 Eye Plaques (Highlight of the Conference award ). Australian Brachytherapy Conference (ABG 2010) , Melbourne , 2010

Xiao W, Graham P, Hao JL, Li Y (2010). Down-regulation of stem cell marker-CD44 sensitizes prostate cancer cells to radiation. The St George and Sutherland Hospital Medical Research Symposium, 30 September.

Xiao W, Graham P, Madigan MC, Hao JL, Khatri A, Li Y (2010). HDAC inhibitor sodium butyrate can inhibit prostate cancer cell growth via regulation of CD44 and HER2 expression. The Australian Society for Medical Research (ASMR), 7 June, Sydney Australia.

199 Xiao W, Graham P, Power C, Hao JL, Li Y (2010). Down-regulation of stem cell marker-CD44 sensitizes prostate cancer cells to radiation. Australian Association of Chinese Biomedical Scientists (AACBS), Sydney, 24 October 2010.

Xiao W, Graham P, Power C, Hao JL, Li Y (2010). Enhanced radiation sensitivity in prostate cancer by down-regulation of stem cell marker-CD44. The Inaugural Biomarker Discovery Conference, 6-10 December, Port Stephens NSW Australia.

You J, Fitzgerald A, Schiller B, Cozzi PJ, Walsh BJ, Willcox M, Wasinger V, Li Y (2010). Identiﬁcation of potential biomarkers for prostate cancer in tears and serum using proteomic approaches. The Inaugural Biomarker Discovery Conference, 6-10 December, Port Stephens NSW Australia.

You J, Fitzgerald A, Cozzi PJ, Zhao Z, Graham P, Russell PJ, Walsh BJ, Willcox M, Li Y (2010). Identiﬁcation of potential biomarkers for prostate cancer in tears and serum using proteomic approaches. HUPO, 19-23 September 2010, Sydney, Australia.

2011

Alshaikh S, Carolan M , Petasecca M , Lerch M , Metcalfe P , Rosenfeld A. Annealing and Reuse of MOSFET dosimeters, EPSEM Conference, Darwin, October, 2011.

Beretov J, Graham P, Kearsley J, Li Y. The HDAC inhibitor Panobinostat (LBH589) signiﬁcantly enhances the radiotherapy effect in breast cancer cell lines. 36 Annual Scientiﬁc Meeting of the Australasian Division of the Internal Academy of Pathology Limited (IAP) Jun3 3-5, 2011, Sydney Convention & Exhibition Centre, Darling Harbour, Australia.

Beydoun N, Graham P, Browne L. Metastatic cutaneous squamous cell carcinoma to the axilla: A review of patient outcomes and implications for future practice. J Med IM Radiat Oncol 2010, 54: A148. 61st ASM RANZCR Perth, October 2010.

Cutajar DL, Hardcastle NG, Loo K, Bucci JA, Chin YS, Rosenfeld AB. MOSFET Dosimetry for Real Time Rectal Wall Measurements During HDR Brachytherapy and EBRT, Australian Brachytherapy Conference (ABG 2011) , Perth , 2011.

Hao JL, Madigan MC, Khatri A, Power CA, Hung TT, Beretov J, Xiao W, Cozzi PJ, Kearsley J, Li Y (2011). CD44 and CD147 confer metastasis and chemoresistance potential on prostate cancer in vitro and in vivo. SGSMRF Symposium, Oct 2011.

200 Hao JL, Madigan MC, Khatri A, Power CA, Hung TT, Beretov J, Xiao W, Cozzi PJ, Kearsley J, Li Y (2011). CD44 and CD147 confer metastasis and chemoresistance potential on prostate cancer in vitro and in vivo. 12th Australasian Prostate Cancer Conference, 1-4 August 2011.

Howard L, Cutajar D, Chin Y, Bucci J, Rosenfeld A. In vivo urethral dosimetry for 125I permanent implant prostate brachytherapy: A study using Si mini- spectroscopy detectors. Australian Brachytherapy Conference (ABG 2011) , Perth , 2011.

Loo KJ, Petasecca M, Han S, Cutajar DL, Weaver M, Lerch MLF, Metcalfe PE, Miekle S, Pospisil S, Jakubek J, Bucci JA, Zaider M, Rosenfeld AB. Brachyview: In-Prostate Real Time Seed Position Imaging For Prostate Brachytherapy Using Medipix Camera. Australian Brachytherapy Conference (ABG 2011) , Perth , 2011.

Ragusa, C. Advanced Practice Techniques in CT-Axial scanning/bolus tracking. ASMMIRT, Adelaide Australia, 2011.

Weaver M, Petasecca M, Cutajar DL, Lerch MLF, Pospisil S, Jakubek J, Rosenfeld AB. Improving QA in eye brachytherapy using 3D dose reconstruction form eye plaques, Australian Brachytherapy Conference (ABG 2011), Perth , 2011.

Xiao W, Graham P, Power C, Dong QH, Kearsley J, Li Y (2011). Combination therapy of the histone deacetylase inhibitor LBH589 with radiation is an effective regimen for human prostate cancer. SGSMRF Symposium, Oct 2011.

201 COMMUNITY ENGAGEMENT

Professor B Allen Rotary Club lectures. President, International Union of Physics & Engineering Sciences in Medicine.

Dr Yong Li Board Member of St George Research Foundation, Australia (2010-). Editorial Board Member of The Open Biomarker Journal, USA (2010). The Honorary Editorial Board of Current Biomarker Findings, UK (2010) Invited talk at BIT’s 3rd Annual World Cancer Congress, 22-25 June, Singapore. (2010) Invited Talk, Sino-Australian Seminar on angiogenesis in cancer treatment, St George Clinical School, 18th of Nov 2010 Australia. Invited talk, Faculty of Medicine, Deakin University 2011.

Kevin Loo Kevin Loo, has presented 2 seminars at Rotary Club on BrachyView project and role of QA in prostate brachytherapy treatment: PhD Scholars Evening, 7th June 2010, Parramatta City Club. Australian Rotary Health Christmas Dinner, 8th December 2010, The Epping Club, Epping

Professor Anatoly Rosenfeld Member of MSAC Assessment Panel Brachytherapy for the Treatment of Prostate Cancer, Health and Aging Committee MSAC application 1089. Outstanding Research Contribution to Cancer Research in NSW, Research Report Cancer Institute NSW, 2010. Member of Grant Research Panel (GRP) of NHMRC

202 CANCER CARE DEPARTMENT OF PALLIATIVE CARE, CALVARY HEALTH CARE SYDNEY

DEPARTMENTAL STAFF*

Head of Department Dr. Jan Maree Davis B.Med (Hons) FRACP FAChPM

Senior Medical Staff Dr. Frank Brennan MB BS FRACP FAcHPM Dr. Amy Waters MBBS FRACP FAChPM Dr. Judith Lacey MBBS FRACP FAcHPM

Research Staff Professor Elizabeth Lobb PhD., MAppSci, B.AdEd. Professor of Palliative Care (Allied Health), Calvary Health Care Sydney and Cunningham Centre for Palliative Care; Adjunct Professor, School of Medicine, the University of Notre Dame, Sydney, Honorary Associate, NH&MRC Clinical Trials Centre, University of Sydney.

Dr. Christine Sanderson, BA, BMBS, MPH, FRACP Staff Specialist in Palliative Medicine, Calvary Health Care Sydney; Research Fellow, CareSearch, Flinders University of South Australia, PaCCSC (Palliative Care Clinical Studies Co-operative Investigator; ImPACCT (Improving Palliative Care through Clinical Trials) Investigator

Dr. Jane Mowll, PhD. B. Soc Wk., RN Research Associate

Nursing (St George Hospital) Linda Magann CNC Mary Lafferty CNS Vicki Croydon CNS Monita Mesuria CNS

Nursing (The Sutherland Hospital) Lee Khaw CNC

Nursing Research Staff Ms. Lesley White, RN Ms. Louise Bryce, RN

203 RESEARCH GRANTS#

Category I - Nationally Competitive Grants:

Clark, K., Greaves, J., Dawes, A., Ryan, J., Norman, R., Lobb, EA, Olver, I., Clayton, J., Tattersall, MHN, Glare, P. Pilot randomized study of tele-medicine consultation versus face-to-face consultation in palliative medicine. NH&MRC Palliative Care Development Grant ID 500207. 2009-2010.

Category II - Other competitive grants:

Victorian Cancer Agency – Early Career Seed Grant - $73,451. 2010-2011 Prevalence and predictors of long term psychological morbidity in bereaved cancer care-givers CIs Zordan, R., Hudson, P, Trauer, T., Prince, M., Lobb, EA, Hall, C.

Cancer Council Australia, Cancer Australia, National Breast Cancer Foundation $594,540 Too much, too soon? The impact of treatment-focused genetic testing in patients newly diagnosed with breast cancer. Meiser B, Mitchell G, Tucker K, Saunders C, Geelhoed E, Hopper J, Watts K. AIs: Kirk J, Lobb EA, Barlow-Stewart K, Friedlander M, Thewes B, Southey M, Gleeson M, Kelly P.

Cancer Institute NSW 2011 -2016 South West Sydney Translational Cancer Research Unit Ingham Health Research Institute CI De Souza, P. Members of ImPACCT (Agar, M., Cole, A., Lobb, EA., Sanderson, C. Clayton, J. Lovell, M. Clark, K., Davidson, P., Eckermann, S., Luckett, T., Philipps, J.) $1,793,300

Sydney Catalyst: The Translational Cancer Research Centre of Central Sydney and Regional NSW University of Sydney. CI. Simes, J. et al. AI Lobb, EA as member of Cunningham Centre for Palliative Care $6,350,000

South-Eastern Translational Cancer Research Centre University of New South Wales. CI Ward, R. et al. Lobb, EA as member of Cunningham Centre for Palliative Care. $6,500,000

Cancer Institute NSW Research Infrastructure Grant. 2009-2013. Agar M, Davidson P, Clark, K., Clayton J. Good, P., Lovell M, Sanderson C, Lobb, EA NSW Palliative Care Research Collaborative Group (ImPaCCT)

Category III – Industry and other research funding:

204 RESEARCH PROJECTS IN PROGRESS

Title Investigators

Prevalence and predictors of long term psychological morbidity in CIs Zordan, R., Hudson, P, Trauer, T., Prince, M., bereaved cancer care-givers. Lobb, EA, Hall, C..

CIs Meiser B, Mitchell G, Tucker K, Saunders C, Too much, too soon? The impact of treatment-focused genetic testing in Geelhoed E, Hopper J, Watts K. AIs: Kirk J, Lobb patients newly diagnosed with breast cancer. EA, Barlow-Stewart K, Friedlander M, Thewes B, Southey M, Gleeson M, Kelly P. A study to explore factors which contribute to coping with uncertainty in patients diagnosed with incurable cancer. 2009-2010. St. George Hospital Kearsley, J., Lacey, J., Lobb, EA. Cancer Care Centre. Clark, K., Greaves, J., Dawes, A., Ryan, J., Norman, Pilot randomized study of tele-medicine consultation versus face-to-face R., Lobb, EA, Olver, I., Clayton, J., Tattersall, MHN, consultation in palliative medicine. Glare, P.

Translational Cancer Research Group, South Eastern Sydney. Group Davis JM. member.

ORIGINAL PEER-REVIEWED PUBLICATIONS

Zilliacus, E., Meiser, B., Lobb, EA., Kelly, P., Barlow-Stewart,K., Kirk, J., Spigelman, A., Warwick, L., Tucker, K. Are video-conferenced consultations as effective as face-to-face consultations for hereditary breast/ovarian cancer genetic counseling? Genetics in Medicine, 2011; 13(11); 933-941.

Lobb, EA., Halkett, G., Nowak, A. “Patient and caregiver perception of communication of prognosis in high grade glioma” J Neurooncol, 2011; 104:315–322

Lobb, EA. Swetenham, K., Agar, M. Currow, DC. A collateral beneﬁt of research in palliative care, Letter to the Editor. Journal of Palliative Medicine, 2011; 14(9); 986-987.

Halkett, G., Kristjanson, L., Lobb, EA., Little, J., Jiwa, M., Shaw, T., Taylor, M.,Spry, N. Information needs and preferences of women as they proceed through radiation therapy for breast cancer. Pt Edu & Couns, doi:10.1016/j.pec.2011.05.010.

Wakeﬁeld, CE, Watts, KJ, Meiser, B., Sansom-Daly, U., Barratt, A., Mann, GJ, Lobb, EA, Gaff, CL, Howard, K., Patel, MI. Development and pilot testing of an online screening decision aid for men with a family history of prostate cancer. Patient Education and Counseling 2011; 83:64–72.

205 Tobin, B., Lobb, EA., Roper, E. Ingham, J. Is the patient voice under-heard in family conferences in palliative care? A question from Sydney, Australia. Journal of Pain and Symptom Management, 2011; 41(2); 2-5.

De Morgan, S., Butow, PN, Lobb, EA., Price, M., Nehill, C. Development and pilot testing of a communication aid to assist clinicians to communicate with women diagnosed with ductal carcinoma in site (DCIS). Supportive Care in Cancer, 2011; 19(5):717-23.

Zilliacus, E., Meiser, B., Lobb EA, Kirk, J., Dudding, T., Warwick, L., Barlow-Stewart, K., Tucker, K. “I think it’s wonderful that these things can be done”: Women’s experience of Tele-health Cancer Genetic Counseling. Journal of Genetic Counseling 2010; 19(5):463-472.

McConigley, R., Halkett, G., Lobb, EA, Nowak, A., Caring for someone with high-grade glioma: a time of rapid changes for caregivers. Palliative Medicine, 2010; 24(5), pp 473-479.

Lobb, EA, Oldham, L., Vojkovic, S., Kristjanson, L, Smith, J., Brown, J., Husain, M., Dwyer, V., Fournier, C. Frontline Grief: The impact of multiple-deaths on staff in community palliative care. J. Hospice & Palliative Care Nursing, 2010; 12(4), 225-233 July/August.

Lobb, EA, Kristjanson, L., Aoun, S., Monterosso, L.Halkett, G., Davies, A. Predictors of Complicated Grief: A Systematic Review of the Empirical Studies. Death Studies, 2010; 34:673-698.

Zilliacus, E., Meiser, B., Lobb, EA, Kirk, J., Spigelman, A., Warwick, L., Tucker, K. The virtual consultation: practitioner’s experience of tele-health genetic counseling. J. Tele-Health & e-Health. 2010; 16 (3), 350-357.

Lobb, EA., Barlow-Stewart, K., Suthers, G, Hallowell, N. Treatment focussed DNA testing in newly diagnosed cancer patients: some implications for clinical practice. Short Report Clin Genet 2010: 77: 350–354.

Halkett, GKB., Lobb, EA, Oldham, L., Nowak, A. The information and support needs of patients diagnosed with high grade glioma. Patient Education and Counseling 2010; 79 (1), 112-119.

Halkett, G, Kristjanson, L, Spry, N, Lobb, EA, O’Driscoll, K. Meeting breast cancer patients’ information needs during radiotherapy: What can we do to improve the information that is currently provided? European Journal of Cancer Care, 2010; 19 (4) 538-547.

206 Brennan FP. The Limits of Hope – The cost to Susan Sontag of being true to herself. Journal of Palliative Care 2010; 26(1) : 133-134. 2011, Reprinted in Newsletter of the Australian New Zealand Society of Palliative Medicine.

Brennan FP. Who was Lou Gehrig? NSW Palliative Medicine Society Newsletter. Autumn-Winter Edition 2010.

Brennan FP. A Short Talk on Hope. Journal of Illness, Crisis and Loss 2010; 18(3): 259-261.

Brennan FP. Ethical Aspects of Palliative Care. CASE 2010

Brennan FP. “Bring on the Angels” – H.L.Mencken, Death and Palliative Care. American Journal of Hospice and Palliative Care 2011; 28(8): 573-575. Reprinted in Newsletter of the Australian New Zealand Society of Palliative Medicine.

Brennan FP. ‘Crime or Care ?’ The Problem of Cause of Death and Intention to Kill in End of Life Care. NSW Medico-Legal Society Meeting. March 2 2011. Published on NSW Medico-Legal Society Website.

Brennan FP. Motor Neurone Disease - Where Does Hope Lie ? Speech given at the Day of Hope and Remembrance, NSW Motor Neurone Disease Association, May 3 2011. Newsletter of the NSW Motor Neurone Disease Association 2011. Reproduced in the Newsletter of Clare Holland Hospice Volunteer Newsletter, 2011.

Spruyt O, Brennan FP. Palliative Care in the Asia-Paciﬁc Region – the Role of Australasian Palliative Link International (APLI). Journal of Palliative Medicine 2011; 14(9): 988-989.

Brennan FP. On Hope. Wel-Com - Newsletter of the Archdiocese of Wellington, New Zealand, October 2011.

Brennan FP. Book Review - Wrestling with the Angel by Kent Kopelman. Journal of Palliative Care 2011; 27; 4: 316.

Brennan FP. Response to Bioethical Case Study. Journal of Bioethical Inquiry 2011; 8 (2): 217-218.

207 Brennan FP. John Keats and Wilfred Owen Lessons in Palliative Care. Journal of Palliative Care (In Press)

OTHER PUBLISHED MATERIAL (BOOKS, BOOK CHAPTERS, REVIEWS)

Lobb, EA. & Gaff, C. Handbook of Communication in Cancer and Palliative Care, Oxford University Press (OUP) Eds. D. Kissane, B. Bultz, P. Butow, I. Finlay. 2010. Chapter 22: Communicating genetic risk. P259-268

Brennan FP. Paediatric Palliative Care as a Basic Human Right. In: Pfund R, Fowler-Kerry S.(eds) Perspectives on Palliative Care for Children and Young People- A Global Discourse. Radcliffe Publishing. 2010.

Brennan FP. Palliative Care in Children and Adolescents – A Human Rights Perspective. In : Holcroft R. (ed) Treatment Strategies – Paediatrics. Cambridge Resources Centre, 2010. Accessible at : http://viewer.zmags.com/publication/18ab08e6

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

Lobb, EA, Hudson, P., Zordan, R., Trauer, T., Williams, A.., “Supporting family caregivers of hospitalised palliative care patients: Results of an intervention study.”, IPOS 13th World Congress of Psycho- Oncology 15-20th October, 2011. Turkey.

Lobb, EA., Kearsley, J., Lacey, J., Liauw, W., White, L., Hosie, A. A study to explore factors which contribute to coping with uncertainty in patients with advanced cancer. IPOS 13th World Congress of Psycho-Oncology 15-20th October, 2011. Turkey.

Lobb, EA., Halkett, G., Nowak, A. “Patient and caregiver perception of communication of prognosis in high grade glioma” IPOS 13th World Congress of Psycho-Oncology 15-20th October, 2011. Turkey. POSTER

Taylor, J. Juraskova, I., Lobb, EA, Carter, J., Philippa, E., Wain, G., Dalrymple, C. Experiences of women with vulvar intraepithelial neoplasia (VIN): A qualitative insight, MASSC, International Symposium on Supportive Care in Cancer. 2011 POSTER.

Lobb, EA., Lacey, J., Kearsley, J., Liauw, W., Thomas, D., Hosie, A., White, L. “A study to explore factors which contribute to coping with uncertainty in patients with advanced cancer” 18th International Congress on Palliative Care, Montreal, Canada 5-8 October, 2010. Proffered Paper.

208 Lacey, J., Connell, S., Kearsley, J., Lobb, EA, Sanderson, C., Brennan, F. Identifying strategies to support hope. 18th International Congress on Palliative Care, Montreal, Canada 5-8 October, 2010. Proffered Paper.

Watts KJ, Wakeﬁeld CE, Meiser B, Sansom-Daly U, Barratt A, Patel MI, Lobb EA, Gaff CL, Howard K, Mann GJ. An online screening decision aid for men with a family history of prostate cancer: development and pilot-testing. European Meeting on the Psychological Aspects of Genetics (EMPAG). Scandinavia. 2010.

Zilliacus,EM., Meiser, B., Lobb, EA., Barlow-Stewart, K.,. Kelly, P., Kirk, J.,Spigelman, A., Warwick, L., Tucker, K. Is tele-genetics as effective as face-to-face consultations for hereditary breast/ovarian cancer genetic counselling? European Meeting on the Psychological Aspects of Genetics (EMPAG), Scandinavia 2010.

Meiser, B., Gleeson, M., Watts, JK, Saunders, C., Mitchell, G., Lobb, EA., Barlow-Stewart, K., Kirk, J., Tucker, K.. Acceptance, experiences and information preferences of young women newly diagnosed with breast cancer regarding treatment-focused genetic testing. European Meeting on the Psychological Aspects of Genetics (EMPAG), Scandinavia 2010.

Brennan FP. April 4 2011. Renal Supportive Care. Combined Nephrology and Palliative Medicine Meeting, North Shore Hospital Auckland, New Zealand.

Brennan FP. April 4 2011. Symptom Management in ESRD – 2011 Australian and New Zealand Society of Palliative Medicine (ANZSPM) Fora. Hamilton New Zealand.

Brennan FP. April 5 2011. Symptom Management in ESRD – 2011 Australian and New Zealand Society of Palliative Medicine (ANZSPM) Fora. Christchurch, New Zealand

Brennan FP. April 7 2011. Symptom Management in ESRD – 2011 Australian and New Zealand Society of Palliative Medicine (ANZSPM) Fora. Wellington, New Zealand

Brennan FP. April 9 2011. Update on Renal Palliative Care. Annual Conference of the New Zealand Branch of the Australian and New Zealand Society of Palliative Medicine (ANZSPM), Wellington, New Zealand.

Brennan FP. October 14 2011. Renal Palliative Care- An Overview. Cuisle Beatha International Palliative Care Conference, Galway, Ireland.

Brennan FP. November 5 2011. Advance Care Planning in ESRD. Renal Society of Australasia (RSA) Conference, Palmerston North, New Zealand.

Brennan FP. November 30 2011. The Role of Palliative Care in Motor Neurone Disease. International Motor Neurone Disease Conference, Sydney.

Davis JM. Palliative Care Pain & Symptom Management. Workshops, Kuala Lumpur, 23-25 October 2010.

209 Davis JM. Cancer Pain Management. Malaysian Association for the Study of Pain, Penang 30 October 2010 & Malaya 19 October 2010.

Davis JM. Asia Paciﬁc Hospice Network, Penang, 13 July 2011. Palliative Care Symptom Management Workshops

Davis JM. Palliative Care Pain & Symptom Management Workshops. Kuala Lumpur 29-31 October 2011. Hospis Malaysia

Davis JM. Palliative Care Symposium on Symptom Management, Manilla Hospice, Philippines, Philippines Central Hospital – GIT Symptoms, Psychological Distress, Palliative Care for Non-Cancer Illnesses.

Davis JM. Asia Paciﬁc Cancer Conference Kuala Lumpur, 10-12 November 2011. Understanding Mechanisms of Cancer Cachexia; Measurable Outcomes in Palliative Care.

National/State

Lobb, EA., Kearsley, J., Lacey, J., Liauw, W., White, L., Hosie, A. A study to explore factors which contribute to coping with uncertainty in patients with advanced cancer. National Palliative Care Conference, Cairns, 30 August – 2nd September, 2011. ORAL.

Lobb, EA., Halkett, G., Nowak, A. “Patient and caregiver perception of communication of prognosis in high grade glioma” National Palliative Care Conference, Cairns, 30 August – 2nd September, 2011. POSTER

Lobb, EA., Halkett, G., Fournier, C., Nowak, A. Understanding the carers’ experience of living with high grade glioma, COSA, Perth, WA. 15th November, 2011.POSTER

Halkett, G., Lobb, EA, Fournier, C., Nowak, A. Understanding the patients’ experience of living with high grade glioma, COSA, Perth, WA. 15th November, 2011. POSTER

Watts KJ, Wakeﬁeld CE, Meiser B, Sansom-Daly U, Barratt A, Patel MI, Lobb EA, Gaff CL, Howard K, Mann GJ. A tailored online screening decision aid for men with a family history of prostate cancer: Development, pilot-testing and evaluation. Winner of “Best of the Best” Posters COSA, Perth, November 2011.

Lobb, EA., Lacey, J., Kearsley, J., Liauw, W., Thomas, D., Hosie, A., White, L. “A study to explore factors which contribute to coping with uncertainty in patients with advanced cancer” NSW Palliative Care Conference, Hands on in the Hunter, November 2010

Lobb, EA., Lacey, J., Kearsley, J., Liauw, W., Thomas, D., Hosie, A., White, L. A study to explore factors which contribute to coping with uncertainty in patients with advanced cancer. Central Health Network - Clinical Quality & Research Forum. Sutherland Hospital, November 16th, 2010.

210 Meiser B, Gleeson M, Watts K, Tucker K, Kirk J, Saunders C, Barlow-Stewart K, Lobb EA, Mitchell G. Acceptance, experiences and information preferences of young women newly diagnosed with breast cancer regarding treatment-focused genetic testing. KConFab Familial Cancer Conference, Gold Coast, 2010.

Schoﬁeld, P., Butow,PN., Lobb, EA, Goldstein, D, King, M., Girgis, A., Eisenbruch, M., Sze, M., Aldridge, LJ., Jefford, M. A bridge between cultures: Interpreter perceptions of roles, challenges and support needs in the oncology consultation. Diversity in Health Conference, Melbourne, June 2010 POSTER

Lobb, EA., Halkett, G., Nowak, A. “It’s a terrible shock and you start to feel like you’re starring in somebody else’s movie”: Communication of prognosis in high grade glioma” Clinical Oncological Society of Australia, Melbourne, November, 2010. POSTER

Brennan FP. September 12 2010. Renal Supportive Care – An Overview. Pre-Conference Workshop on Renal Palliative Care. Australian and New Zealand Society of Nephrology Conference, Perth, Western Australia.

Brennan FP. September 12 2010. Symptom Management in ESRD. Pre-Conference Workshop on Renal Palliative Care. Australian and New Zealand Society of Nephrology Conference, Perth, Western Australia.

Brennan FP. January 28 2011. Creation of a Renal Supportive Care Service. Department of Renal Medicine, Royal Brisbane Hospital, Brisbane.

Brennan FP. January 28 2011. Renal Supportive Care – An Overview. Kidney Club, Nephrologists, Brisbane, Queensland.

Brennan FP. February 23 2011. The importance of Narrative at End of Life. Pastoral Care Conference. Catholic Institute of Sydney, Strathﬁeld.

Brennan FP. July 29 2011. Symptom Management in ESRD. Australian and New Zealand Society of Palliative Medicine (ANZSPM) Medical and Surgical Updates. St Vincent’s Hospital, Melbourne.

Davis JM. NSWPCA Professional Development Workshop Forum 28 May 2010. Coping with the Work of Palliative Care.

Davis JM. ANZSPM National Conference, Adelaide, 15 September 2010. Care of the Dying Pathway Workshop.

211 Magann, L. Lafferty M, Croydon, V. Mesuria, M. Davis, J. 11th National Palliative care Conference Cairns 30/8-2/9/11 Improving End of Life Care in residential Aged Care Facilities (RACF) - A Model to Improve Care and Communication (poster).

COMMUNITY ENGAGEMENT

The Palliative Aged Care Program evaluation: a collaborative palliative care quality improvement project between Calvary Health Care Sydney and four residential aged care facilities within the Sutherland Shire. Evaluation methods include documentation audits, resident questionnaires, bereaved carer surveys and staff surveys. Investigators: Hosie, A., Garrard, J., Worledge, V., Devery, M., McCarthy, U., Belfanti, C., Davis, J.M., Cahill, P., Lobb, L., Phillips, J. & Rojas, E.,

212 WOMEN’S AND CHILDREN’S HEALTH SERV ICES

DEPARTMENT OF WOMEN’S HEALTH

DEPARTMENTAL STAFF

Head of Department Professor Michael Chapman MBBS, MD, FRCOG, FRANZCOG, CREI (Professor of O&G, UNSW)

Senior Consultant Staff Professor Kate Moore MBBS, MD, FRANZCOG, CU (Professor of O&G) Dr Gregory Davis MBChB, MD, FRACP (Conjoint Senior Lecturer, UNSW) Dr Emmanuel Karantanis MBBS, PhD, FRANZCOG, CU (Conjoint Senior Lecturer, UNSW) Dr Gregory Robertson MBBS, FRANZCOG, CGO (Conjoint Senior Lecturer, UNSW) Dr Gavin Sacks MBBS, DPhil, MRCOG, FRANZCOG (Conjoint Senior Lecturer, UNSW) Dr Margaret Booth MBBS, FRANZCOG Dr John Breen MBBS, FRANZCOG Dr Greg Cario MBBS, FRCOG, FRANZCOG Dr Danny Chou MBBS, FRANZCOG Dr Ludmilla Collins MBBS, FRANZCOG Dr Chandra Krishnan MBBS, FRANZCOG Dr Trent Miller MBBS, FRANZCOG Dr Michael O’Connor AM, MD BS, MHL, DCH, DDU, FRCOG, FRANZCOG, JP Dr James Opperman MBBS, FRANZCOG Dr Kenneth Roper MBBS, FRANZCOG Dr David Rosen MBBS, FRANZCOG Dr Steven Thou MBBS, FRANZCOG Dr Queeny Wong MBBS, FRANZCOG Dr Andrew Zuschmann MBBS, FRANZCOG

Research Staff Senior Midwifery Research Fellow Professor Caroline Homer PhD, RN, RM (Professor of Midwifery, UTS)

Research Midwife Lynne Roberts RN, MMid, MHlthSc (Associate, UTS)

213 RESEARCH GRANTS

Category I - Nationally Competitive Grants:

Homer CSE, Ellwood D, Oats J, Foureur MJ, Sibbritt D, McLachlan H, Forster D, Dahlen H. Birthplace in Australia: A prospective cohort study. NHMRC Project Grant: APP1022422. $790,175 (2012-2015).

Homer CSE, Foureur MJ, Davis D, Adams J, Porteous A. Does Continuity Of Midwifery Care Increase Vaginal Birth After Caesarean (VBAC): A Randomised Controlled Trial. NHMRC Project Grant Application: APP1023352. $257,550 (2012-2015).

Kildea S, Martensson L, Webster J, Homer CSE, Stalepton H, Beckmann M, Gao Y, Gibbons K. NHMRC Project – APP1024872 – Impact on Caesarean Rates following Injections of Sterile Water (ICARIS) – A randomised controlled trial. 456,760 (2102-2014).

Foureur M, Homer CSE, Fenwick J, Davis D, Sorensen R, Forbes I. Theorising the relationship between birth unit design and the communication patterns of labouring women and their maternity care providers. ARC Discovery Grant 2011-2013. 2011: $100,512; 2012: $91,340; 2013: $86,140. (DP110104108).

214 RESEARCH PROJECTS IN PROGRESS

DEPARTMENT OF WOMEN’S HEALTH IS A COLLABORATING CENTRE FOR THE FOLLOWING INTERNATIONAL MULTICENTRE RANDOMISED CONTROLLED TRIALS

Title Investigators

PI Dr Jon Barrett. Mount Sinai Hospital, Toronto, Twin Birth Study (TBS). Canada. Vaginal Birth v’s Caesarean Section for twins. SI at St George Hospital Dr Greg Davis Preterm Prelabour Rupture Of Membranes close to Term (PPROMT) Trial. PI Prof Jonathan Morris. Royal North Shore Early planned birth v’s expectant management for women with PPROM Hospital, Sydney. 34-37 weeks. SI at St George Hospital Dr Greg Davis PROGesterone after previous preterm birth for the prevention of neonatal PI Prof Caroline Crowther. University of Adelaide RESpiratory distress Syndrome (PROGRESS) Trial. and Women’s and Children’s Hospital, Adelaide. Does using vaginal progesterone pessaries in women at risk of preterm SI at St George Hospital Dr Greg Davis birth reduce respiratory distress syndrome in the infant? Australasian antenatal Study To Evaluate the Role Of Intramuscular PI Prof Caroline Crowther. University of Adelaide Dexamethasone versus betamethasone (ASTEROID) Study. and Women’s and Children’s Hospital, Adelaide. Betamethasone v’s dexamethasone for antenatal corticosteroids for SI at St George Hospital Dr Greg Davis. women at risk of birth less than 34 weeks gestation. DEPARTMENT OF WOMEN’S HEALTH IS A COLLABORATING CENTRE FOR THE FOLLOWING AUSTRALIAN MULTICENTRE RANDOMISED CONTROLLED TRIALS Triggers for pre eclampsia. PI Dr Jane Ford. University of Sydney at Royal The onset of proteinuric pre eclampsia is acutely triggered by maternal North Shore Hospital infection. SI at St George Hospital Dr Greg Davis

OTHER SINGLE-SITE STUDIES

Cholestasis in Pregnancy. Management experience, especially using Ursodeoxycholic Acid, in PI Dr Greg Davis pregnant women with cholestasis Blood Pressure Recording Device Validation Study. Assessing the Omron T9P, Omron HEM-907 and non-mercury PI Prof Mark Brown sphygmomanometer for accuracy, compared to mercury sphygmomanometer, in pregnant women.

ORIGINAL PEER-REVIEWED PUBLICATIONS

Mark Brown, Lynne Roberts, Gregory Davis, George Mangos. Can we use the Omron T9P automated blood pressure monitor in pregnancy? Hypertens Preg. Epub 2010, Sep 16.

Mark Brown, Lynne Roberts, Callie McKenzie, George Mangos, Greg Davis. A Prospective Randomised study of Automated versus Mercury blood pressure recordings in pregnancy (PRAM study) Hypertens Pregnancy. 2012;31(1):107-19. Epub 2011 Jan 10.

Choi, YC Kho, LM Rhodes, GK Davis, MG Chapman, DF Murrell. Outcomes of 11 Pregnancies in 3 Patients with Recessive Forms of Epidermolysis Bullosa. Brit J Derm. 2011; 165:700-01

215 Georgina M. Chambers, Elizabeth A. Sullivan, Marian Shanahan, Maria T. Ho, Katelyn Priester, Michael G. Chapman. Is in vitro fertilisation more effective than stimulated intrauterine insemination as a ﬁrst-line therapy for subfertility? A cohort analysis. ANZJOG 2010; Vol 50 (3) 207-307

Yueping Alex Wang; Michael Chapman; Michael Costello; Elizabeth Anne Sullivan. Better perinatal outcomes following transfer of fresh blastocysts and blastocysts cultured from thawed cleavage embryos: a population-based study. Human Reproduction 2010; doi: 10.1093/humrep/deq067

Chapman, MG, Kilani, S, & Cooke, S. Time course of meiotic spindle development in MII oocytes Zygote, 2011. 19, pp 55-62 C_Cambridge University Press.

Dean, JH, Chapman, MG & Sullivan, EA. The effect on human sex ratio at birth by assisted reproductive technology (ART) procedures – an assessment of babies born following single embryo transfers, Australia and New Zealand, 2002-2006 British Journal of Obstetrics and Gynaecology, 2010; 117:1628-1634

Sponberg S, O’Connor MC, Rudzki S. Fitness to Serve The New ADF Medical Employment Categories ADF Health, 2011. 12: 56-59.

Sullivan, EA, Chapman MG, Wang, YA & Adamson, G. Population-Based Study of Caesarean Section after In Vitro Fertilization in Australia, Birth-Issues in Perinatal Care, 2011. 37, pp 184-191

O’Connor MC. Strategies for Regulating and Improving the Conduct of Military Physicians: Are Courts Martial the Answer? ADF Health, 2011. 12: 65-70.

Koch J, Costello M F, Chapman M G, Kilani S. Twice-frozen embryos are no detriment to pregnancy success: a retrospective comparative study. American Society for Reproductive Medicine, 2011. 96, no. 1, July, pp 58-62

Kilani S, Cooke S, Tilia L, Chapman M. Does meiotic spindle normality predict improved blastocyst development, implantation and live birth rates? American Society for Reproductive Medicine, 2011. 96, no. 2, Aug, pp 389-393

Ben Kroon, Neil Johnson, Michael Chapman, Anusch Yazdani, Roger Hart, on behalf of the Australasian CREI Consensus Expert Panel on Trial evidence (ACCEPT) group Fibroids in infertility – consensus statement from ACCEPT (Australasian CREI Consensus Expert Panel on Trial evidence) ANZJOG 2011; Vol 51 (4) 289-295 Aug 11

216 Wang YA, Costello M, Chapman M, Black D, Sullivan EA. Transfers of fresh blastocysts and blastocysts cultured from thawed cleavage embryos are associated with fewer miscarriages, Reproductive BioMedicine Online, 2011. 10 Sept 2011

Choi SD, Kho YC, Rhodes LM, Davis GK, Chapman MG, Murrell DF. Outcomes of 11 pregnancies in three patients with recessive forms of epidermolysis bullosa. BJD © 2011 British Association of Dermatologists 2011 165, pp693-706

Russell P, Anderson L, Lieberman D, Tremellon K, Yilmaz H, Cheerala B, Sacks GP. The distribution of immune cells and macrophages in the endometrium of women with recurrent reproductive failure I: Techniques. J Reprod Immunol. 2011; 91:90-102.

King K, Smith S, Chapman M, Sacks GP. Detailed analysis of peripheral blood natural killer (NK) cells in women with recurrent miscarriage. Hum Reprod 2010; 25(1):52-8.

Smith R, Homer A, Homer DJW, Homer CSE. Learning about grief and loss through Harper’s story (Original Research paper). MIDIRS Midwifery Digest 2011, 21(1): 19-21.

Hammond A, Gray J, Smith RM, Fenwick J, Homer CSE. Same ... Same but Different: Expectations of graduates from two midwifery education courses in Australia. Journal of Clinical Nursing, 2011. 20(15-16):2315-24.

Sullivan K, Lock L, Homer CSE. Factors that contribute to midwives staying in midwifery: A study in one Area Health Service in New South Wales, Australia. Midwifery, 2011. 27: 331–335.

Catling-Paull C, McDonnell N, Moores A, Homer CSE. Maternal mortality in Australia: learning from maternal cardiac arrest. Nursing and Health Sciences. 2011. 13 (1):10–15.

Catling-Paull, C, Johnston, R. Ryan, C, Foureur, MJ, Homer CSE. Clinical interventions that increase the uptake and success of vaginal birth after caesarean section: a quantitative systematic review. Journal of Advanced Nursing, 2011. 67 (8): 1646–1661.

Catling-Paull, C, Johnston, R. Ryan, C, Foureur, MJ, Homer CSE. Non-clinical interventions that increase the uptake and success of vaginal birth after caesarean section: a quantitative systematic review. Journal of Advanced Nursing, 2011. 67(8):1662-76.

217 Sheehy A, Foureur MJ, Catling-Paull C, Homer CSE. Examining the content validity of the Birthing Unit Design Spatial Evaluation Tool (BUDSET) within a woman-centred framework. Journal of Midwifery & Women’s Health, 2011. 56 (5): 494–502.

Shaban IA, Hatamleh R, Khresheh R, Homer CSE. Childbirth practices in Jordanian public hospitals: Consistency with evidence-based maternity care? International Journal of Evidence Based Health Care (ERA ranking B), 2011. 9: 25–31.

Dahlen H, Homer CSE, Leap N, Tracy S. From social to surgical: Historical perspectives on perineal care during labour and birth. Women and Birth, 2011. 24(3): 105-111.

Catling-Paull C, Dahlen H, Homer CSE. Multiparous women’s conﬁdence to have a publicly-funded homebirth: a qualitative study. Women and Birth, 2011. 24 (3): 122-128.

Homer CSE, Kurinczuk J, Spark P, Brocklehurst P, Knight M. Planned vaginal delivery or planned caesarean delivery in women with extreme obesity. BJOG: British Journal of Obstetrics and Gynaecology 2011. 118 (4): 480-487.

Homer CSE, Biggs J, Vaughan G, Sullivan E. Mapping maternity services in Australia: Location, classiﬁcation and services. Australian Health Review, 2011. 35, 222–229.

Adams J, Lui CW, Sibbritt D, Broom A, Wardle J, Homer CSE. Attitudes and Referral Practices of Maternity Care Professionals regarding Complementary and Alternative Medicine: Literature Review. Journal of Advanced Nursing 2011 doi: 10.1111/j.1365-2648.2010.05510.x

OTHER PUBLISHED MATERIAL (BOOKS, BOOK CHAPTERS, REVIEWS)

Sacks GP. Natural killer cell analysis. In ‘How to improve your ART success rates’. Ed G Kovacs. Cambridge University Press 2011.

218 PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

Homer CSE. (invited keynote speaker). Midwifery – making a difference to outcomes for women and health systems 2nd FOCUS in O&G Conference. Hong Kong June 2011.

Homer CSE, Vaughan G, Sullivan E. Australasian Maternity Outcomes Surveillance System: A surveillance system looking at rare and serious conditions in pregnancy. International Confederation of Midwives Conference, Durban, South Africa. June 2011.

National

Roberts LM, Davis GK, and Brown MA. Validating the mercury free UM-101 sphygmomanometer in pregnancy. Poster presentation at St George Hospital Medical Symposium 2011

Bonnette S, Broom A, Homer CSE. Choosing freebirth in NSW: An exploration of expectations and experience. Australian College of Midwives 17th Annual Conference. Sydney October 2011. Women and Birth, 24 (S1): S10.

Davis D, Homer CSE. Meta-WHAT! Cochrane reviews and other research stuff for dummies [Workshop]. Australian College of Midwives 17th Annual Conference. Sydney October 2011. Women and Birth, 24 (S1): S19.

Sibbritt D, Homer CSE, Adams J. The self prescribed use of aromatherapy oils by pregnant women: Cause for concern? Australian College of Midwives 17th Annual Conference. Sydney October 2011. Women and Birth, 24 (S1): S24.

Catling-Paull, Homer CSE, Foureur MJ, Azzopardi C, Cameron D, Clarke J, Elmes R, Kitschke J, Koay A, Lennon K, McMurtrie J, Pratt J. Skews R, White J. Introducing ... the National Publicly Funded Homebirth Consortium. Australian College of Midwives 17th Annual Conference. Sydney October 2011. Women and Birth, 24 (S1): S36.

Sacks, G. Thromboelastography: a new test for targeting anticoagulant therapy in women with repeated implantation failure. 14th World Congress on human reproduction, Melbourne, Dec 2011

219 Sacks, G. Natural killer cells: superstition or science? IVF Australia, Sydney, Nov 2011

Sacks, G. What on O&G registrar need to know about IVF. RANZCOG trainees course. Sydney Nov 2011

Sacks, G. How to read and assess a scientiﬁc paper. Fertility Nurses Australia meeting. Sydney April 2011

Sacks, G. Recurrent miscarriage: Moving to individualized care. GP south division. Kogarah June 2011

Sacks, G. Implantation and early pregnancy. START course. Sydney March 2011

Sacks, G. The science and the art of individualized care. IVFA nurses update. Feb 2011

Sacks, G. What on O&G registrar need to know about IVF. RANZCOG trainees course. Sydney Nov 2010

Sacks, G. Miscarriage management: New approaches. Royal Hospital for Women. Nov 2010

Sacks, G. Miscarriage management: New approaches. Trainees education day. Liverpool Hospital. Aug 2010.

Smith S, Sacks G. Natural Killer cells and recurrent miscarriage. SydFlow meeting, May 2010

Sacks, G. Natural killer cells: testing and analysis. Virtus health meeting Sydney March 2010

220 Sacks, G. Adjuvant therapy in IVF. FNA annual meeting. Sydney March 2010

Sacks, G. Miscarriage management in 2010: the new and controversial. GPCE. Sydney May 2010

Sacks, G. Natural Killer cells: Fact or Fantasy? CREI trainees course. Sydney May 2010

COMMUNITY ENGAGEMENT

None reported.

221 DEPARTMENT OF UROGYNAECOLOGY

DEPARTMENTAL STAFF

Head of Department Prof. Kate Moore MBBS, BD, FRCOG, FRANZCOG, CU

Senior Consultant Staff Dr Emmanuel Karantanis MBBS, BD, FRCOG, FRANZCOG, CU

Research Staff Dr Colin Walsh MBBS, MRCOG, Senior Research Fellow Dr Kylie Mansﬁeld MSC, PhD, Lecturer Dr Vivien Wong MCchB FRANZCOG Dr Lilach Leibenson, MD

Detrusor Muscle Laboratory Dr Ying Cheng MSC PhD (Senior Research Ofﬁcer)

Research Associates Ms Wendy Hayes, Physiotherapist Ms Janette O’Toole, Physiotherapist

Research Students Dr Colin Walsh MBBS, MRCOG, PhD Student Angelie Thakar, ILP Student Zoey Stephenson, ILP Student Rihan Shabab, ILP Student

Nursing Research Staff Ms Wendy Allen BN, Clinical Nurse Specialist (part-time) Ms Anne Siddins, Research Registered Nurse (part-time) Ms Katrina Parkin, Dip Nurse, Midwifery, Research Registered Nurse (part-time) Ms Hayley Leek, BN, Clinical Nurse Specialist/Nurse Continence Advisor (part-time)

222 RESEARCH GRANTS

NHMRC – 2008 - 2010 $33,000 pa POPPY (Physiotherapy for Pelvic Organ Prolapse) Project Application No: 508925

Commonwealth Government – 2008 - 2010 $35,000 pa Continence Outcomes Measures Validation and Clinical Translation Project

Pﬁzer Competitive Grants Program – August 2009 – August 201 $75,000 USD New OAB Targets: ATP, Stretch, Tachykinins and Vanilloid Interation in the Bladder Mucosa

NHMRC – 2009 - 2011 $140,000 pa Non-neuronal ATP: Regulation of release and Action in the bladder

Int’l Urogynaecology Assoc. – 2009 - 2010 $20,000 USD Low Count Bacteriuria and ATP Release in Refractory Detrusor Overactivity

St George Medical Research Foundation – 2010 $10,000 Clean intermittent Self-catheterisation: Comparison of single-use Versus reuse of Nelaton Catheters – Health and Cost Implications.

223 RESEARCH PROJECTS IN PROGRESS

Title Investigators

Use of the PFMT Motivation Questionnaire to predict response to pelvic S. Sarma, A Thakar, W, Allen, C. Walsh, K. Parkin, physiotherapy E Karantanis, K. H. Moore.

An aliquot study of ATP release during cystometry in women with Y. Cheng, W. Allen, K. Mansﬁeld, C. Walsh, E. incontinence Burcher, K. H. Moore

ATP release during acute exacerbation of urge symptoms in relation to C. Walsh, Y. Cheng, K. Mansﬁeld, C. Walsh, E. bacterial cystitis Burcher, K. H. Moore and A. Siddins

C. Walsh, Y. Cheng, K. Mansﬁeld, C. Walsh, E. Low grade bacteria uria in women with refractory detrusor overactivity Burcher, K. H. Moore and A. Siddins

Randomized controlled trial of Electromagnetic Chair versus routine PFMT J. O’Toole, A Thakar, W. Hayes, W. Allen, E. for stress incontinence Karantanis, K. H. Moore

Randomized controlled trial of single use versus re-use catheters in Z Stephenson, A Reus, E. Karantanis, H. Leek, patients who self-catheterize for bladder outﬂow obstruction K. H. Moore

Randomized controlled trial of cough test in performance of TVT for stress incontinence

Case – control study of demographic factors predisposing to anal E. Karantanis, K Parkin, K. Gardiner, V. Paton, incontinence in women with third degree obstetric tears D. Lubowski

Three Dimensional Pelvic Ultrasound in women with Avulsion defects of the V. Wong, H.P. Dietz, K.H. Moore Levator An

ORIGINAL PEER-REVIEWED PUBLICATIONS

Cheng Y, Mansﬁeld KJ, Allen W, Walsh CA, Burcher E, Moore KH. Does Adenosine Triphosphate released into voided urodynamic ﬂuid contribute to urgency signalling in women with bladder dysfunction? JUrol, 2010 183:1082-1086

Walsh CA, Moore KH, Recurrent Stress Urinary Incontinence after Synthetic Midurethral Sling Procedure. Obstet & Gynae 2010 115:1296 - 1301

Walsh CA, Allen W, Moore KH. ‘Urinary incontinence’ post-radiotherapy: A diagnostic conundrum. Obstet & Gynae, 2010: 30; 424-5

Nitti VW, Kopp Z, Lin ATL, Moore KH, Oefelein M, Mills W. ‘Can we predict which patient will fail drug treatment for overactive bladder? A think tank discussion.’ Neurourol. Urodynam, 2010. 29:652-657

Birder LA, Kanai AJ, Cruz F, Moore KH, Fry CH. ‘Is the Urothelium Intelligent?’ Neurourol. Urodynam. 2010. 29:598-602

224 Woodman JR, Mansﬁeld KJ, Lazzaro VA, Lynch W, Burcher E, Moore KH, Immunocytochemical characterisation of cultures of human bladder mucosal cells. BMC Urology, 2011. 11:5-30

Walsh CA, Moore KH. Overactive bladder in women: does low-count bacteriuria matter? An Invited review. Neurology & Urodynamics. 2011: 30; 32-37

Cheng Y, KJ Mansﬁeld, SL Sandow, P Sadananda, E Burcher, Moore KH, Porcine bladder and urothelial, myoﬁbroblast and detrusor muscle cells: characterisation and ATP release. Frontiers in Pharmacology 2011: 2; 27-36

Indraratna P, Walsh CA, Moore KH. Intra-operative cystoscopy in gynaecological surgery. Aust N Z J Obstet Gynaecol 2011 51: 272-5.

Cheng Y, Walsh CA, Mansﬁeld KJ, Allen W, Moore KH. Relationship between bacteriuria and ATP concentrations in voided urodynamics ﬂuid: 2-year prospective study. Neurourology & Urodynamics 2011:30:921-922.

Walsh CA, Allen W, Parkin K, Mukerjee C, Moore KH. “Low-count” bacteriuria in refractory idiopathic detrusor overactivity versus controls. Urogynaecologia 2011 25: e4 11-15

Shahab RB, Sarma S, Moore KH, Kuteesa WMA, Cebola M, Walsh CA, Wang YA, Karantanis E. Randomized Controlled Trial of Cough Test versus no Cough Test in the Tension-Free Vaginal Tape Procedure effect upon Voiding Dysfunction and 12 month Efﬁcacy. Accepted Int Urogynecol J, E Pub Nov 12, 2011

Karantanis E, Painter V, Moore KH. Does patient activity level affect 24-hour pad test results in stress-incontinent women? Neurology & Urodynamics 2011:30;1-5

Walsh CA, Siddins A, Parkin K, Mukerjee C, Moore KH. Prevalence of “low count’ bacteriuria in female urinary incontinence versus continent female controls: a cross-sectional study. Int. Urogynaecol J, 2011; 22: 1267-1272

Book Chapter

Moore KH, “Economic Aspects of Urinary Incontinence”. Textbook of Female Urology and Urogynecology, Third Edition, Editors: Cardozo L, Staskin D, Robinson D, Kelleher CJ, Mostwin JL, Herschorn S, Rovner E, Toozs-Hobson P, Dmochowski RR, Sand PK, Smith ARB, Nitti V. 2010: Vol.1. 153-161 Informa Healthcare USA

225 PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

Walsh C, Allen W, Mukerjee C, Moore KH. Refractory Idiopathis Detrusor overactivity: Incidence of “Low-count” bacteriuria during acute symptomatic exacerbation. Int. Urogynecol J, 2010; 21: S258 – S259. ICS-IUGA, Toronto Canada, 2010.

Hausman N, Burcher E, Moore KH, Mansﬁeld K, Grundy D, Chess-Williams R. The inﬂuence of neurkinin a on purinergic and muscarinic receptor signalling in the bladder. ICS-IUGA, Toronto Canada, 2010.

Cheng Y, Mansﬁeld K, Burcher E, Moore KH. Isolation, immunohistochemical characterization and ATP release from myoﬁbroblast cell cultures from pig bladder mucosa. ICS-IUGA, Toronto Canada, 2010.

Parkin K, Patton V, Lubowski D, Moore KH. A prospective ‘bottom up’ study of the direct personal and investigation costs of faecal incontinence in ambulatory men and women in relation to severity. Int’l Cont Soc, Glasgow, 2011

Hagen S, Stark D, Glazener C, Sinclair L, Wilson D, Norrie J, Dickinson S, McPherson G, Frawley H, Moore KH, Walker A. A multicentre randomised controlled trial of pelvic ﬂoor muscle training intervention for women with pelvic organ prolapse. Int’l Cont Soc, Glasgow, 2011

Moore KH Aetiology of Detrusor Overactivity. UROGYNZ, New Zealand, 2011

National

Reus A, Karantanis E, Moore KH, Walsh C. Clean Intermittent Self-Catheterisation, a Randomised Control Trial: Comparing single-use versus use of Nelaton Catheters – Health and Cost Implications. ANZCJ. 2010:16:4: 106. Cont. Found. of Aust. A.S.M., Alice Springs.

Walsh CA, Allen WA, Parkin K, Mukerjee C, Moore KH. Incidence of “low-count” bacteriuria at urodynamic testing. ANZCJ.2010: 16.4: 118-119.Cont. Found. of Aust. A.S.M., Alice Springs.

226 Teahan O, Maher A, DonaldT, Cheng Y, Burcher E, Moore KH. Identifying Novel Urinary Biomarkers – Towards a New Therapeutic Targeting for Overactive Bladder (OAB) Disease Proceedings of ASCEPT Annual Scientiﬁc Meeting, Melbourne, 2010.

Moore KH Eight year follow-up of vaginal ring pressaries: Complications and Outcomes: Urogynaecological Society of Australasia Annual Scientiﬁc Meeting – March 2010 Adelaide.

Moore KH Pressaries before,during and after pregnancy: Obstetric Trauma for Pelvic Floor Repair - Australian Gynaecological Endoscopic Soc. ASM , Adelaide , June 2011

COMMUNITY ENGAGEMENT

Professor Kate Moore, Dr Karantanis, and the staff of the Pelvic Floor Unit and Detrusor Muscle Laboratory are actively involved in promoting knowledge about Urinary Incontinence in the local, national and international community.

227 DEPARTMENT OF PAEDIATRICS

DEPARTMENTAL STAFF*

Dr. Ana Dosen MBBS FRACP Dr. Adrienne Moline MBBS FRACP Dr. Anthony Epstein MBBS FRACP Dr. Bob Fonseca MBBS FRACP MMed (ClinEpid) Dr. Charles Scarf MBBS FRACP Dr. Con Papadopoulos MBBS FRACP MAppMgt(Health) Dr. Kylie Yates MBBS FRACP MMed (ClinEpid) Dr. Maria Craig Maria Craig MBBS PhD FRACP MMed(ClinEpid) Dr. Mary-Louise Freckman MBBS FRACP Dr. Rani Sachdev MBBS FRACP Dr. Scott Dunlop MBBS FRACP

All paediatricians have conjoint teaching appointments with the UNSW Faculty of Medicine.

RESEARCH GRANTS#

Environmental determinants of type 1 diabetes, Craig ME, Rawlinson WD, 2011, $22 000, Rebecca Cooper Research Foundation

The role of environmental factors in diabetes complications – a 12 year follow up of an incident cohort, Poon M, Donaghue KC, Craig ME, 2011, $10 000, Novo Nordisk Regional Diabetes Support Scheme

The contribution of obesity, inﬂammation and autonomic function to the vascular health of adolescents with diabetes, Cho YH, Donaghue KC, Craig ME, 2011, $12 000, Novo Nordisk Regional Diabetes Support Scheme

Intervention to reduce the risk of diabetic retinopathy and early adverse retinal changes in type 1 diabetes, Donaghue K, Jones T, Cheung N, Couper J, Craig ME, Cameron F, Cotterill A, Davis E 2010-2014, $250 037, NHMRC Project Grant (#632521)

The prevention of diabetes in children and adolescents, Garnett SP, Cowell C, Poon M, Donaghue K, Craig ME, 2010, $18 980, Rebecca Cooper Research Foundation

228 Viral triggers of autoimmunity and T1DM: a prospective study of at risk children, Craig ME, 2008- 2010, $152 000, NHMRC Project Grant (#510258)

Viral triggers of autoimmunity and type 1 diabetes, Craig ME, 2007- 2011, $44 500, NHMRC Career Development Award (#455363)

RESEARCH PROJECTS IN PROGRESS

None reported.

ORIGINAL PEER-REVIEWED PUBLICATIONS

Craig ME, Donaghue KC, Cameron FJ, Silink M. Change of HbA1c reporting to the new SI units. Medical Journal of Australia.2011, 195 (9):514.

Yeung G, Rawlinson WD, Craig ME. Enterovirus Infection and Type 1 Diabetes Mellitus - A systematic review of molecular studies. British Medical Journal 2011, 342:d35 doi:10.1136/bmj.d35 IF 13.4

Downie E, Craig ME, Hing S, Cusumano J, Chan AK, Donaghue KC. Continued reduction in the prevalence of retinopathy in adolescents with type 1 diabetes - role of insulin therapy and glycemic control. Diabetes Care 2011, 34:2368–2373. IF 7.1

Cho H, Craig ME, Hing S, Gallego PH, Poon M, Chan A, Donaghue KC. Microvascular complications assessment in adolescents with 2- 5 years duration of Type 1 diabetes from 1990-2006. Pediatric Diabetes 2011, 12(8), 682-9.

Benitez-Aguirre P, Craig ME, Sasongko MB, Jenkins AJ, Wong TY, Wang JJ, Cheung N, Donaghue KC Retinal vascular geometry predicts incident retinopathy in young people with type 1 diabetes: a prospective cohort study from adolescence. Diabetes Care 2011, 34(7); 1622-7, IF 7.1

Kaur H, Donaghue KC, Chan AK, Benitez-Aguirre P, Hing S, Lloyd M, Cusumano J, Pryke A, Craig ME. Vitamin D deﬁciency is associated with retinopathy in children and adolescents with type 1 diabetes. Diabetes Care 2011, 34:1400–1402, IF 7.1

Iwasenko JM, Howard J, Arbuckle S, Graf N, Hall B, Craig ME, Rawlinson WD. CMV infection is detected frequently in stillbirths, in association with fetal thrombotic vasculopathy. Journal of Infectious Diseases 2011, 203(11);1526-33, IF 5.9

229 Tran F, Nguyen HT, Vu DC, Bui TP, Can NT, Nguyen KN, Huynh LT, Nguyen KP, Nguyen VT, Tran HM, Tran D, Hoang TD, Harkin N, Armstrong K, Jameson K, Pham A, Cowell CT, Craig ME. Glycemic Control in Children with Neonatal Diabetes and Type 1 Diabetes in Vietnam. International Health, 2011, 3 (3), 188-92.

Akerblom HK; The TRIGR Study Group. The Trial to Reduce IDDM in the Genetically at Risk (TRIGR) study: recruitment, intervention and follow-up. Diabetologia. 2011, 54(3):627-633, IF 6.6

Hameed S, Ellard S, Woodhead HJ, Neville KA, Walker JA, Craig ME, Armstrong T, Yu L, Eisenbath G, Hattersley AT, Verge CF. Persistently autoantibody negative (pan) type 1 diabetes mellitus in children. Pediatric Diabetes 2011 May;12(3 Pt 1):142-9.

Rana M, Munns CF, Selvadurai H, Simonds S, Cooper P, Woodhead HJ, Hameed S, Verge CF, Lafferty AR, Crock PA, Craig ME. Increased detection of Cystic Fibrosis Related Diabetes in Australia. Arch Dis Child, 2011, 96(9):823-6.

Craig ME, Donaghue KC, Cameron FJ, Silink M. Change of HbA1c reporting - targets for children and adolescents (letter). Medical Journal of Australia 7 Nov 2011, doi: 10.5694/mja11.10583

Garnett SJ, Srinivasan S, Birt S, Ambler G, Lawrie E, Cowell CT, Craig ME. Evaluation of glycemic status in young people with clinical insulin resistance; fasting glucose, fasting insulin or an OGTT? Clinical Endocrinology (Oxf). 2010, 72(4), 475-480 IF 3.4

Nair S, Leung K-C, Rawlinson WD, Naing Z, Craig ME. Enterovirus Infection induces Cytokine and Chemokine Expression in Insulin Producing Cells. Journal of Medical Virology, 2010, 82(11):1950-7.

Warne GL, Armstrong KL, Faunce TA, Wilcken BM, Boneh A, Geelhoed E, Craig ME: The case for newborn screening for congenital adrenal hyperplasia in Australia. Medical Journal of Australia 2010, 192:107, IF 3.3

Craig ME, Wong C. Diabetic Ketoacidosis: an update. Medical Observer, June 2010 29-31

Rana M, Munns CF, Selvadurai H, Donaghue KC, Craig ME. Cystic Fibrosis Related Diabetes in Children-Gaps in the Evidence? Nature Clinical Practice Endocrinology and Metabolism, 2010, 6(7):371-8.

230 OTHER PUBLISHED MATERIAL (Books, book chapters, reviews) (Not to include conf abstracts)

Craig ME, Twigg SM, Donaghue KC, Cheung NW, Cameron FJ, Conn J, Jenkins AJ, Silink M, for the Australian Type 1 Diabetes Guidelines Expert Advisory Group. National evidence-based clinical care guidelines for type 1 diabetes in children, adolescents and adults. Australian Government Department of Health and Ageing, Canberra , 2011.

Chapters Donaghue KC, Keech T, Craig ME, O’Connell P. A ‘Cure’ for Diabetes and its Complications? In A Modern Epidemic - Expert Perspectives on Obesity and Diabetes. Ed: Louise Baur, Stephen Twigg and Roger Magnusson. Sydney University Press, 425-455, 2011 ISBN:978-1-920899-85-1

Poon M, Rawlinson WD, Craig ME. Diabetes and Viruses in Australia and the Asia Paciﬁc Region. In Diabetes and Viruses, Ed: Hyoty H, Toniolo A. Springer, 2012

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

2010

Dr Maria Craig International Society for Pediatric and Adolescent Diabetes Annual Scientiﬁc Meeting, Buenos Aires Should we target viral disease to prevent diabetes?

United Nations DPI/NGO Conference Advance Global Health, Melbourne A grassroots approach to chronic health conditions in resource poor countries

Australasian Paediatric Endocrine Group Fellows’ Meeting How I do it: calcium and bones

Australasian Paediatric Endocrine Group Annual Scientiﬁc Meeting Satellite Symposium Use of Aromatase Inhibitors

Asia Paciﬁc Paediatric Endocrine Society Fellows’ Meeting, Xi’an China Pituitary Disease in Childhood

National Hospital for Paediatrics Paediatric Endocrine Workshop, Hanoi, Vietnam Paediatric Endocrine Emergencies

Australian Diabetes Society/Australian Diabetes Educators Association Annual Scientiﬁc Meeting Adolescence, Alcohol, Drugs and Diabetes - a Dangerous Mix

231 Diabetes Expert Forum, Sydney Type 2 diabetes in adolescents

Dietitians’ Association of Australia, Sydney Use of anthropometry in clinical practice

2011

Dr Maria Craig Asia Paciﬁc Paediatric Endocrine Society Meeting Bali, Indonesia, Evidence based care in type 1 diabetes

Three VVVs Diabetes Workshop Sanya, China, Diabetic Ketoacidosis

Asia Paciﬁc Paediatric Endocrine Society Fellows’ Meeting and CME Update, Hanoi, Vietnam

Endocrine Emergencies; Type 1 diabetes guidelines: putting evidence into practice

Paediatric Endocrine Workshop, Ho Chi Minh City, Vietnam

Diagnosis and Management of Central & Peripheral Precocious Puberty Sanoﬁ-Aventis International Diabetes Advisory Board Meeting, San Diego, USA Evidence based management of type 1 diabetes – insulin therapy

Growth Hormone Research Society Prader Willi Evidence Based guidelines Meeting Systematic review of Growth Hormone in Prader-Willi Syndrome

Cho YH, Craig M, Srinivasan S, Benitez-Aguire P, Donaghue K. Lower Sex-Hormone Binding Globulin Levels Are Associated With Cardiac Autonomic Dysfunction In Girls With Type 1 Diabetes. Australasian Paediatric Endocrine Group ASM 2010.

Armstrong K, Ditchﬁeld S, Dung VC, Craig M, Warne G. What might overseas efforts have to offer the Australian CAH community? Australasian Paediatric Endocrine Group ASM 2010.

Benitez-Aguirre P, Sasongko MB, Craig ME, Wang JJ, Cheung N, Jenkins A, Wong TY, Donaghue KC. Retinal Vessel Tortuosity Predicts Microvascular Complications in Young Persons with Type 1 Diabetes. Australasian Paediatric Endocrine Group ASM 2010.

232 Fiona Tran, Dung C. Vu, Hoan T. Nguyen, Thao P. Bui, Ngoc T. Can, Khanh N. Nguyen, Loan T. Huynh, Phuong Nguyen, Khanh P. Nguyen, Hiep M. Tran, Dong Tran, Kate Armstrong, Christopher T. Cowell, Sian Ellard, Deborah MacKay, Karen Temple, Andrew T. Hattersley, Maria E Craig. Novel And Known Molecular Mutations Causing Neonatal Diabetes In Vietnam. Australasian Paediatric Endocrine Group ASM 2010.

Tran F, Huang C, Lloyd M, Woodhead HJ, Elliott KA, Crock PA, Howard NJ, Craig ME. Population Based Incidence Of Diabetes In Australian Youth In New South Wales: Increase In Type 1 Diabetes But Not Type 2 Diabetes. Australasian Paediatric Endocrine Group ASM 2010.

Benitez-Aguirre P, Sasongko MB, Craig ME, Wang JJ, Cheung N, Jenkins A, Wong TY, Donaghue KC. Baseline Retinal Venular Tortuosity Is Associated With Elevated Urinary Albumin Excretion In Young Persons With Type 1 Diabetes. Asia Paciﬁc Pediatric Endocrine Society ASM 2010.

Dung VC, Bui Phuong Thao , Khu Thi Khanh Dung , Can Thi Bich Ngoc , Nguyen Ngoc Khanh, Nguyen Thi Hoan, Nguyen Thanh Liem, Kate Armstrong, Maria Craig, Garry Warne. Growing numbers of children with CAH in Vietnam? Asia Paciﬁc Pediatric Endocrine Society ASM 2010.

Pham A, Donaghe KC, Chan A, Craig ME. Younger Age at Diagnosis of Diabetes Increases Risk of Coeliac Disease. International Society for Pediatric and Adolescent Diabetes ASM 2010.

Craig ME. Should we target viral disease to prevent diabetes? International Society for Pediatric and Adolescent Diabetes Annual Scientifc Meeting, Buenos Aries 2010 (Plenary Lecture).

Muske C, Lloyd M, Werther G, Cameron F, Rodda C, Craig ME. The Epidemiology of Diabetes in children and adolescents in Australia, ADS/ADEA Meeting 2010.

Rana M, Munns CF, Selvadurai H, Simonds S, Cooper P, Woodhead H, Hameed S, Verge CF, Lafferty A, Crock PA, Craig ME. Population–Based Incidence of CFRD in NSW and ACT, Australia. American Diabetes Association Meeting 2010, Diabetes (Supp) 1796-P

Fiona Tran, Hoan T Nguyen, Dung Chi Vu, Thao P Bui, Ngoc T Can, Khanh N Nguyen, Loan T Huynh, Khanh P Nguyen, Van TT Nguyen, Hiep M Tran, Dong Tran, Thuy D Hoang, Nuala Harkin, Kate Armstrong, Karen Jameson, Anna Pham, Christopher T Cowell, Craig ME. Glycemic Control in Children with Neonatal Diabetes and Type 1 Diabetes in Vietnam. American Diabetes Association Meeting 2010, Diabetes (Supp) 1453-P

Maria E Craig, Fiona Tran, Dung C Vu, Hoan T Nguyen, Thao P Bui, Ngoc T Can, Khanh N Nguyen, Loan T Huynh, Phuong Nguyen, Khanh P Nguyen, Hiep M Tran, Dong Tran, Thuy D Hoang, Nuala Harkin, Kate Armstrong, Karen Jameson, Anna Pham, Christopher T Cowell, Sian Ellard, Deborah MacKay, Karen Temple, Andrew T Hattersley. Neonatal Diabetes in Vietnam. American Diabetes Association Meeting 2010, Diabetes (Supp)

233 Tran F, Lloyd M, Woodhead HJ, Crock PA, Howard NJ, Craig ME. Population-based incidence of type 2 diabetes in Indigenous and non-Indigenous youth in New South Wales, Australia: 2001-2008. American Diabetes Association Meeting 2010, Diabetes (Supp) 2791-P.

Nair S, Leung K-C, Rawlinson WD, Naing Z, Craig ME. Enterovirus infection induces cytokine and chemokine expression in insulin producing cells. American Diabetes Association Meeting 2010, Diabetes (Supp) 1338-P.

Al-Shabeeb A, Talati R, Catteau J, Sanderson K, Niang Z, Rawlinson W, Howard NJ, Craig ME. Enterovirus Infections Are Common in Children at Risk of Type 1 Diabetes and Associated with Transient and Persistent Autoimmunity. American Diabetes Association Meeting 2010, Diabetes (Supp) 0067-OR

Nair S, Al-Shabeeb A, Rawlinson WD, Craig ME. Enterovirus infection induces cytokine and chemokine expression in insulin producing cells. Islet Biology Meeting, Canberra 2010

Nair S, Leung K, Naing Z, Al-Shabeeb A, Rawlinson W D, Craig ME. Enterovirus infection induces cytokine and chemokine expression in insulin producing cells. Australian Society for Microbiology Annual Scientiﬁc Meeting, Sydney. 2010

Al-Shabeeb A, Talati R, Catteau J, Sanderson K, Naing Z, Rawlinson W, Howard N J, Craig M E. (2010) Enterovirus infections are common in children at risk of Type 1 Diabetes and associated with transient and persistent autoimmunity. Australian Society for Microbiology Annual Scientiﬁc Meeting, Sydney.

Rawlinson W, Chow S, Craig M, Hall B, Jones C, Lloyd A, Hamilton S, Scott G (2010) Effects of CMV infection on cytokines in amniotic ﬂuid and tissue of living and stillborn babies, and the implications for pathogenesis of fetal damage. 3rd Congenital Cytomegalovirus Conference, Paris. 23-25 Sept, 2010

Iwasenko JM, Howard J, Arbuckle S, Graf N, Hall B, Craig M, Rawlinson WD (2010) CMV infection is frequently detected in stillbirths, in association with fetal thrombotic vasculopathy. 3rd Congenital Cytomegalovirus Conference, Paris. 23-25 Sept, 2010

Scott GM, Iwasenko JM, Wang S, Glover H, Hall B, Leung CMR, Craig ME, Jones CA, Rawlinson WD (2010) Changes in expression of tumour suppressor proteins induced by human cytomegalovirus infection of the placenta and placental cell lines. 3rd International congenital cytomegalovirus conference, Paris. 23-25 Sept, 2010

Hamilton S, Scott G, Chow S, Arbuckle S, Graf N, Hall B, Craig M.E, Rawlinson W (2010) The role of human cytomegalovirus in stillbirth and other adverse outcomes of pregnancy. International Stillbirth Alliance (ISA) and International Society for Study and Prevention of Perinatal and Infant Death (ISPID) Joint Conference, Sydney. 9-11 Oct 2010

234 Iwasenko JM, Howard J, Arbuckle S, Graf N, Hall B, Craig M, Rawlinson WD (2010) CMV infection is frequently detected in stillbirths, in association with growth restriction and vascular abnormalities. International Stillbirth Alliance (ISA) and International Society for Study and Prevention of Perinatal and Infant Death (ISPID) Joint Conference, Sydney. 9-11 Oct 2010

Dr Bob Fonseca International Society of Quality in Health Care [ISQUA] - Paris, France Parent Information Record: providing carers with key information on their child’s illness and admission to hospital

COMMUNITY ENGAGEMENT

None reported.

235 AGED AND EXTENDED CARE AND REHABILITATION

DEPARTMENT OF AGED CARE

DEPARTMENTAL STAFF

Peter Smerdely MBBS (Hons) MPH PhD FRACP Senior Staff Specialist, Geriatric Medicine & Endocrinology Director Department of Aged Care, St George Hospital Co Director, Aged & Extended Care, Central Health Network Network Executive Clinical Director, Central Health Network Conjoint Associate Professor UNSW Member, SESLHD Board

Litsa Morﬁs MBBS FRACP Staff Specialist, Geriatric Medicine Conjoint Lecturer, UNSW

Chris Dedousis MBBS FRACP Senior Staff Specialist, Geriatric Medicine & Thoracic Medicine Conjoint Appointment with Southcare, Sutherland Hospital Conjoint Senior Lecturer, UNSW

Sarah Baldwin MBBS FRACP Staff Specialist, Geriatric Medicine Conjoint Lecturer, UNSW

Tony Youssef BSc (MED) MBBS FRACP Staff Specialist, Geriatric Medicine Conjoint Appointment with Southcare, Sutherland Hospital

236 Nicholas Cordato MBBS (Hons 1) FRACP PhD Senior Staff Specialist, Geriatric Medicine Conjoint appointment with CRAGS, Calvary Hospital

Grant Pickard MBChB FRACP Staff Specialist, Geriatric Medicine Appointed to Medical Assessment Unit

Yun Xu MBBS FRACP Staff Specialist, Geriatric Medicine Conjoint appointment with CRAGS, Calvary Hospital

Louise Baird MBBS FRACP Staff Specialist, Geriatric Medicine Appointed to Medical Assessment Unit & Aged Care Conjoint Lecturer, UNSW

Kannie Chuang MBBS FRACP Staff Specialist, Geriatric Medicine Appointed to General Medicine Unit

RESEARCH GRANTS#

Dr Nicholas Cordato, 2011, St George & Sutherland Medical Research Foundation

RESEARCH PROJECTS IN PROGRESS

None reported

237 ORIGINAL PEER-REVIEWED PUBLICATIONS

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews) (Not to include conf abstracts) Nil

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

None reported

COMMUNITY ENGAGEMENT

All staff members are actively involved with the community. Regular lectures are given to groups auspiced by Alzheimer’s Australia, Department of health and St George Hospital.

238 DEPARTMENT OF REHABILITATION MEDICINE ST GEORGE HOSPITAL

DEPARTMENTAL STAFF

Dr John Estell MBBS., BSc., MSpMed., FAFRM(RACP)

Dr Scott Hannan MBBS, BMedSci., FAFRM(RACP) FACRM Conjoint Senior Lecturer UNSW

Dr Kenneth Chan MBBS., BSc(Med) FAFRM(RACP)

Dr Brenda Slee MBBS MPH FAFRM(RACP) A/Professor Andrew Cole MBBS (Hons) FAFRM(RACP) FACRM Conjoint Associate Professor, School of Community Medicine UNSW

RESEARCH GRANTS#

None reported

RESEARCH PROJECTS IN PROGRESS

Title Investigators

Cost Beneﬁt of Rehabilitation Care John Estell

On-Site versus Off-site Rehabilitation in Stroke Kenneth Chan, John Estell

On-Site versus Off-site Rehabilitation in Orthopaedic Conditions John Estell

Interventional Spasticity Management Scott Hannan, Brenda Slee, John Estell

Rehabilitation Intensity of Therapy John Estell, Brenda Slee

The Association between Team Characteristics, Performance and Human David Pereira, John Estell Resource Management in Rehabilitation Teams

The Effect of an Acute Rehabilitation (In-reach) Team John Estell

239 ORIGINAL PEER-REVIEWED PUBLICATIONS

Kohler F. Redmond H. Dickson H. Connolly C. Estell J. I nter-rater reliability of functional status scores for patients transferred from one rehabilitation setting to another. Archives of Physical Medicine & Rehabilitation. 2010, 91 (7):1031-7.

Friedbert Kohler, Roger Renton, Hugh G. Dickson, John Estell and Carol E. Connolly Subacute casemix classiﬁcation for stroke rehabilitation in Australia. How well does AN-SNAP v2 explain variance in outcomes? Australian Health Review Volume, 2011, 35(1), pp1-8

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews) (Not to include conf abstracts)

None reported

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

National

“Improving Trauma Patient Journey” 2010 Improving the Healthcare Experience NSW Health Dr John Estell

COMMUNITY ENGAGEMENT

None reported.

240 SOUTHCARE, DIVISION OF AGED AND EXTENDED CARE, SUTHERLAND HOSPITAL AND COMMUNITY SERVICES

DEPARTMENTAL STAFF*

Head of Department A/Prof Peter Gonski MBBS BMed Sci FRACP,conjoint A/Prof UNSW

Senior Medical Staff Staff Specialists Dr C.Dedousis MBBS FRACP Dr S.Phoon MBBS FRACP Dr N.Nyi Nyi MBBS FRACP Dr P.Conroy MBBS FRACR,Dr T.Yousseff MBBS FRACP all conjoint lecturers UNSW

Vocational Registrars Advanced trainees X 2

Nursing & Allied Health Research Staff Ann Stewart CNC - wound care Diane O’Donohue - continence nurse

RESEARCH GRANTS#

None reported

RESEARCH PROJECTS IN PROGRESS

Title Investigators

Improving Service provision for early onset dementia Prof B.Draper et al incl A/Prof Peter Gonski

The effect of including manual therapy in a pulmonary rehabilitation Engel R Gonski PN Beath K program for COPD (currently being considered for publication)

A controlled Trial of vertebroplasty for Acute painful Osteoporotic Clark W. et al (including A/Prof Peter Gonski) fractures-still rcruiting

241 ORIGINAL PEER-REVIEWED PUBLICATIONS

Clark WA,Diamond TH,McNeil HP,Gonski PN,Schlaphoff GP,Rouse JC Vertebroplasty for painful acute osteoporotic vertebral fractures:recent Medical Journal of Australia editorial is not relevant to the patient group that we treat with vertebroplasty MJA 2010; 192:334-7

Stewart A, Baker JD, Elliott D The effects of a sacrococcygeal pilonidal sinus wound on activities of living: thematic analysis of participant interviews Journal of Clinical Nursing 2011; 20:3174-3182

O’Donohue D, Winsor G, Gallagher R, Maughan J, Dooley K, Walsh J (2010) Issues for People living with long-term urinary catheters in the community. British Journal Community Nursing 15 (2): 65-70

OTHER PUBLISHED MATERIAL

Gonski PN The pros and cons of retirement MJA Insight 7.02.11

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

None reported

COMMUNITY ENGAGEMENT

Mental Health: Assessment and diagnosis. Aged care Channel. A/Prof Peter Gonski

242 ALLIED HEALTH SERV ICES

DEPARTMENT OF PHYSIOTHERAPY (SGSHHS)

DEPARTMENTAL STAFF

Acting Head of Physiotherapy St George and Sutherland Hospitals Health Services Susan Sellars

Departmental Staff Unit Head SGH: Sue Sellars TSH: Andrew Lawson

Senior Physiotherapists SGH: Nicole Austin Renee Bowran Narelle Chaseling Wendy Chaseling Wendy Hayes Guni Hinchey Amy Homola Korina Horne Jillian Leiboff Annie Leung Mavis Ng Alex Ng Liane O’Brien Janette O’Toole Paul Ray Tully Rose Bronwyn Scahill Sharlene Thurecht Anna Tierney Nhi Vuong Robyn Whitaker Roman Wu

243 TSH: Grant Gellie Sarah-Jane Lucas Deanne Miro Sue Murray Pam New Anna O’Brien Katie Pagotto Steve Rougellis Belinda Tavares Paul Van den Dolder Cathy Wells Carolyn White Cathy White

Junior Physiotherapists SGH: Melissa Allen Elizabeth Anderson Lucy Armitage James Bender Cathy Brand Elizabeth Bye Florence Check Allison Collins Sandra Elias Denise Facchina Jacqueline Fan Sharon Fok Jessica Friedewald Claire Gill Lina Goh Claire Berry Jason Horton Abigail Hunter Terry Huynh Leisa Johns Nadia Lightfoot David Martens Shevaughn Mawter Timothy McKeown Zoe Michaelff Martin Mock Sharmane Motuliki Joanna Nay Amanda O’Brien

244 Sharon Power Jennifer Roberts Corinne Rootsey Josephine Ruffels Lauren Stanwell Michael (Man Fu) Tang Min Teng Kym Turnell Wendy Uptin Amie Van Ryn Thien Vuong Josephine (Ming San) Yeung

TSH: Lauren Beacroft Rose Coyte Jeremy Daniher Sandra Elias Felicity Goodwin Kristen Haeney Wendy Henriques Elias Khabbaz Helen King Jo Leung Amy Loxley Erica Morgan Jason Tran

Allied Health Assistants SGH: Peter Foessel Terence Lock

TSH: Tracy Usher Sowmya Vasikarla Pam Wong

245 RESEARCH GRANTS#

None reported.

RESEARCH PROJECTS IN PROGRESS

Title Investigators

SGH: Avert (A Very Early Rehabilitation Trial) for stroke patients Principal investigators – Nicole Austin and Principal investigators Melissa Tinsley

SGH: A prospective randomized controlled trial comparing pelvic Principal Investigators- Wendy Hayes floor treatment by a pelvic floor physiotherapist, versus extracorporeal (Physiotherapist), Janette O’Toole magnetic stimulation (Chair study). (Physiotherapist) SGH: Factors affecting women’s motivation in undertaking pelvic floor muscle training (PFMT) to treat stress urinary incontinence Principal Investigator - Kate H Moore (Motivation for PFMT)

Principal investigator – Annie McCluskey TSH: Out-and-about; outdoor mobility following stroke. Associate investigator – Felicity Goodwin

ORIGINAL PEER-REVIEWED PUBLICATIONS

SGH: None reported

TSH: Naylor et al (including Steve Rougellis) 2011 Is discharge knee range of motion a useful and relevant indicator after total knee replacement? (Part 1 and Part 2) both published in International Journal of Public Health Policy and Health Services Research.

P. van den Dolder, P. Ferreira, K. Refshauge. Is soft tissue massage an effective treatment for mechanical shoulder pain? A study protocol. Journal of Manual and Manipulative Therapy 2010;18;1-5

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

SGH: None reported

TSH: None reported

246 PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

SGH: None reported

TSH: None reported

COMMUNITY ENGAGEMENT

SGH: G. Hinchey – presentation “Treatment of Lateral Hip Pain” to the NSW Public Hospitals Musculoskeletal Outpatients Physiotherapy Symposium

TSH: Belinda Tavares – Presentation “Exercise for the prevention and management of osteoporosis.” Community presentation for NSW Arthritis.

247 DEPARTMENT OF OCCUPATIONAL THERAPY

DEPARTMENTAL STAFF

Head of Department Sharryn Fitzgerald B.App.Sc.Occupational Therapy

Unit Head Alison Harle B.App.Sc. Occupational Therapy

Senior Staff Pamela Maryse Arndt B.App.Sc. Occupational Therapy Nadine Morkos B.App.Sc. Occupational Therapy Maree McGlinchey B.App.Sc. Occupational Therapy Sue Shaw B.App.Sc. Occupational Therapy Justine Tinker B.App.Sc. Occupational Therapy Jessica Bassutti B.App.Sc. Occupational Therapy Karen Branch B.App.Sc. Occupational Therapy Stefanie Hall B.App.Sc. Occupational Therapy Frances Dixon B.App.Sc. Occupational Therapy Katie Grattan-Smith B.App.Sc. Occupational Therapy Marie Fournaris B.App.Sc. Occupational Therapy Sara Moloney B.App.Sc. Occupational Therapy Deborah Maiden B.App.Sc. Leisure and Health Science, Master of Occupational Therapy Melissa Duck B.App.Sc. Occupational Therapy Irene Mahoney B.App.Sc. Occupational Therapy Anna Rueda B.App.Sc. Occupational Therapy

Junior Staff Mandy Hanna B.App.Sc. Occupational Therapy Kate McAneny B.App.Sc. Occupational Therapy Nicole Van Kerckhof B.App.Sc. Occupational Therapy Peta McCallum B.App.Sc. Occupational Therapy Sara Veal B.App.Sc. Occupational Therapy Jacquie Canning B.App.Sc. Occupational Therapy Jayne Agostino B.App.Sc. Occupational Therapy Karin Gonzalez B.App.Sc. Occupational Therapy Kate De Valentin B.App.Sc. Occupational Therapy Jillian Hull B.App.Sc. Occupational Therapy Linda Campbell B.App.Sc. Occupational Therapy Jacqui Efthimiou B.App.Sc. Occupational Therapy Jacky Peile B.App.Sc. Occupational Therapy Keryn Ramaker B.App.Sc. Occupational Therapy Michelle Boyd B.App.Sc. Occupational Therapy

248 Lucy Warner B.App.Sc. Occupational Therapy Shereen Mouaﬁ B.App.Sc. Occupational Therapy Sarah Middlebrook B.App.Sc. Occupational Therapy Shun Yee Vanessa Fung B.App.Sc Occupational Therapy

Support Staff Michelle Ranginui Malcolm Stewart

RESEARCH GRANTS#

None reported

RESEARCH PROJECTS IN PROGRESS

None reported

ORIGINAL PEER-REVIEWED PUBLICATIONS

ASET Occupational Therapist - Mandy Hanna Baker, I., de Paula, A., Serratore, L., Hanna, M., Diviney, K., Clark, N., Bailey, V. (2010). Towards Independence: The New South Wales (Australia) Experience of Transition to Adulthood of Young People With Spinal Cord Injury. Published in: Mulcahey, MJ., Topics in Spinal Cord Injury Rehabilitation: children, adolescents, and the transition to adulthood after SCI. A Thomas Land Publication: USA; 16 (1): 55-65.

OTHER PUBLISHED MATERIAL

Rheumatology Occupational Therapist - Nadine Morkos “Arthritis in the Workplace” published in “Arthritis Matters” Winter 2010 – The ofﬁcial magazine of Arthritis NSW and Osteoporosis NSW.

249 PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

None reported

COMMUNITY ENGAGEMENT

Rheumatology Occupational Therapist - Nadine Morkos Member of Arthritis NSW Board Education Sub-Committee Contributed to “Caring for Your Joints” Module 8 in the Challenging Arthritis Program handbooks. The program is designed to provide an opportunity to gain information and acquire skills that will help self manage arthritis and make positive changes to lifestyle, thereby improving quality of life. Also contributed to review of every module in this program. Provided clinical expertise and assisted in the production of Hand Exercise handout developed by Arthritis NSW

250 DEPARTMENT OF SPEECH PATHOLOGY

DEPARTMENTAL STAFF*

Head of Department Claire O’Connor, M.App.Sc (Communication Science & Disorders);, B.App.Sc (Speech Pathology)

Senior Staff Julia Maclean PhD; M.Sc. (Medicine); B.App.Sc (Speech Pathology) Wendy Relf M.Health Sc.(Comm Disorders);B.App.Sc.(Speech Pathology);B.A.(Linguistics & Psychology) Emma Ramirez B.App Sc. (Speech Pathology) Hons Sue Pepper B. App Sc. (Speech Pathology) Rachel Hampshire B.App.Sc.(Speech Pathology) Hons

Junior Staff Vanessa Arnerich B.App.Sc (Speech Pathology) Sascha Burgess B.Speech Path. Christine Chilko B.App.Sc (Speech Pathology) Lucy Kenny B.App Sc (Speech Pathology) Monica Ku B.App Sc. (Speech Pathology) Yris Simon Mendoza B.App.Sc (Speech Pathology) Veronica da Silva B.App.Sc (Speech Pathology)

RESEARCH GRANTS#

Category II - Other competitive grants:

NSW Cancer Institute ‘Research Innovation Grant’ $48,393 “Predicting dysphagia-related complications and improving outcomes in patients treated with head and neck radiotherapy”

251 RESEARCH PROJECTS IN PROGRESS

Title Investigators

Professor Ian Cook (Dept Gastroenterology, St George Hospital; UNSW), Dr Sudarshan Paramsothy (Registrar, Dept Efﬁcacy and safety of cricopharyngeal dilatation Gastroenterology, St George Hospital), Dr Peter Wu (Registrar, in patients with dysphagia who have undergone Dept Gastroenterology, St George Hospital), Dr. Julia Maclean laryngectomy (Speech Pathology, St George Hospital), Dr Michal Szczesniak (Dept Gastroenterology, St George Hospital; UNSW), Ms Grace Zhang (Dept Gastroenterology, St George Hospital) Professor Ian Cook (Dept Gastroenterology, St George Hospital; UNSW), A/Professor Peter Graham (Dept Radiation Oncology, Improving treatment outcomes and preventing long-term St George Hospital), Dr. Julia Maclean (Speech Pathology, St dysphagia after head and neck radiotherapy George Hospital), Dr Michal Szczesniak (Dept Gastroenterology, St George Hospital; UNSW), Ms Grace Zhang (Dept Gastroenterology, St George Hospital)

ORIGINAL PEER-REVIEWED PUBLICATIONS

Maclean, J., Szczesniak, M., Cotton, S., Cook, I., & Perry, A. Impact of a laryngectomy and surgical closure technique on swallow biomechanics and dysphagia severity. Otolaryngology Head and Neck Surgery. 2010; 144, 21-28.

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

None reported

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International Dr Julia Maclean Key note speaker – Laryngology, 2011, London. Dr Julia Maclean Key note speaker – Tri Society Head and Neck conference, 2011, Singapore.

National 12th Annual Scientiﬁc Meeting of the Australian & New Zealand Head and Neck Society Meeting, Sydney 2010. Dr Julia Maclean Key note speaker – Sydney Dysphagia and Oesophagology course, 2011, Sydney.

COMMUNITY ENGAGEMENT

Dr Julia Maclean - Clinical Practice Guideline - NSW Ministry of Health - Care of patients in acute care facilities with a tracheostomy.

252 DEPARTMENT OF NUTRITION AND DIETETICS

DEPARTMENTAL STAFF*

Head of Department Janet Bell- BSc MNutr Diet APD

Senior Staff Maria Chan - BSc (Hons), Master of Nutrition & Dietetics, Adv APD, Grad Dip in Health Science (Exercise & Sport), Certiﬁcate in Business Management, Conjoint Associate Lecturer, UNSW Nina Bonner - BSc, MNutr diet APD Alex McClelland - BSc, MNutr diet APD Lauren Wood - BSc, Nutr diet APD Helen Dragicevich - BSc, Nutr diet APD Natasha Yule - BNutr Diet (Honours), APD Brielle Gosch - BSc(Nutrition, Hons I) , APD, AN Lynelle Thomson - BSc, Nutrition (honours) Daniela Mondello - BSc, Nutr diet APD Julia Phillips - BSc, Nutrition and Exercise Science M Nutr Diet, APD Naomi Crockett - BSc MNutr Diet APD,

Junior Staff Rachel Pons - BNutr Diet, APD Amanda Duffy - BSc, Nutr diet APD Alyssa Fernandez - BSc, Nutr diet APD Stephanie Samantha - BSc, Nutr diet APD Erin Caruana - BSc, Nutr diet APD Kim Parsons-BSc, Nutr diet APD Deanna Cardamis - BSc, Nutr diet APD Amber Raco-BSc - nutrition and exercise science - M Nutr Diet, APD Nella Puz- BSc - MNutr diet APD

253 RESEARCH GRANTS#

Category III – Industry and other research funding:

$10 000 Allied health research grant from Roche Pegasys Initiatives for Learning and Research (PILLAR). Research titled “Nutritional support to improve clinical outcomes and quality of life in patients with viral hepatitis related hepatocellular carcinoma”. Project was investigator initiated by Janet Bell, Amber Lumb and Dr Amany Zekry.

ACI Renal Services Network. Maria Chan has been involved in successfully receiving a $6000 grant to be used for the management of the overweight and obese chronic kidney disease patients on transplant waiting list. She is chair of the steering committee. Systematic review performed. Ongoing review and drafting of guidelines.

RESEARCH PROJECTS IN PROGRESS

Title Investigators

International Nutrition Survey 2011. Helen Dragicevich

Australasia Nutrition care day survey. Janet Bell

Nutrition Day worldwide study for ICU, Aged care and rehabilitation. Julia Phillips/Nina Bonner

Nutrition Clinical Outcomes in Palliative Care PhD. Jodie Ellis

Nutrition management of patients with pre-dialysis chronic kidney disease PhD. Maria Chan (CKD)

ORIGINAL PEER-REVIEWED PUBLICATIONS

Chan M et al. Evidence-based Guidelines for the Nutritional Management of Adult Kidney Transplant Recipients. Journal of Renal Nutrition, Vol 21, No 1 (January), 2011: pp 47–51

Birinder Singh BS, Abas H, Smith B, O’Sullivan A, Chan M, Patwardhan A, Kelly J, Gillin A, Pang G, loyd B, Berger K, Baune B and Singh M. Effect of resistance training during hemodialysis on circulating cytokines: a randomized controlled trial. Eur J Appl Physio. 2010, 15 December.

254 Avesani CM, Trolonge S, Deleaval P, Baria F, Mafra D, Faxen-Irving G, Chauveau P, Teta D, Kamimura M, Cuppari L, Chan M, Heimburger O and Faouque D. Physical activity and energy expenditure in haemodialysis patients: an international survey. Nephrol Dial Transplant, 2011, (0), 1-5.

Watts H, Needham K, Bell J, Talbot P and Pang G.. Poor outcomes among gastrostomy-fed patients in the community. MJA, Volume 191, No 5. September 2009

OTHER PUBLISHED MATERIAL (Books, book chapters, reviews)

Chan M et al The Nutritional Management of Adult Kidney Transplant Recipients Summary of the Evidence-based Guidelines 2010 are ﬁnalised and endorsed through the Dietitians Association of Australia (DAA) http://www.daa.asn.au/ﬁles/DINER/TransplantNutrition_Guidelines_FINAL_090628.pdf and may be viewed on the CARI website http://www.cari.org.au/trans_nutrition_published.php(GESCHN)

McClelland A, Gosch B, Peters K et al. Dietitians Association of Australia (DAA) and New Zealand Dietitians Association working party evidenced based guidelines for nutritional management of pressure ulcers endorsed by DAA. http://daa.collaborative.net.au/dmsweb/frmDINERDetails.aspx?id=865

PRESENTATIONS AT SCIENTIFIC MEETINGS/CONFERENCES

International

Chan M: Nutrition and Metabolism in Renal disease, Annual update. Mexico City, Mexico, May 2011. 3 lectures: Nutrition and Transplantation, Nutritional management in Haemodialysis and Nutritional in Pre-Dialysis CKD.

Chan M: Renal nutrition workshop, National Kidney Foundation, Kuala Lumpur, Malaysia, June , 2011.

Chan M: Nutrition assessment in renal failure, Pre-conference workshop, International society of blood puriﬁcation (ISBP), ASM, Beijing, September 2011

National

Chan M: Malnutrition (SGA) and serum albumin levels, but not body mass index (BMI) values at initiation of dialysis are independent predictors of mortality: a 10 year clinical cohort study. Presented at the Australia and New Zealand Society of Nephrology, Adelaide 2011

255 Chan M: CARI guidelines on nutrition for CKD stage 1-3 at the Australia and New Zealand Society of Nephrology 12-15 September in Perth 2010

Invited Lecture:

Chan M: invitation (with honorarium) by Amgen to present at the CKDMBD (Chronic Kidney Disease Mineral Bone Disorder) Education day for senior nurses

Presentation:

Chan M presented abstract “Malnutrition (SGA) and serum albumin levels, but not body mass index (BMI) values at initiation of dialysis are independent predictors of mortality: a 10 year clinical cohort study” at the SGH & TSH medical symposium on 20/10/2011

Bell - J chaired and coordinated the Volunteer Feeding Assistance Workshop at the Nutrition in Hospital Seminar on 12/8/10

COMMUNITY ENGAGEMENT

Bell J - Co chair of the Agency of Clinical Innovation (ACI) for Home Enteral Nutrition

Bell J - Executive member of the ACI Nutrition in Hospital Committee

Bell J- Member of the Nutrition and Dietetics Advisors Group to the Department of Health

Chan M-Executive member of the ACI Renal Service Network Executive & Chronic Kidney Disease (CKD) and Transplant committees.

Chan M- Member of the NSW Health Chronic Disease prevention sub-group (CKD) committee Ingle J- Executive member on the endocrine ACI network. Developing

Gladman L- Developing Draft Cochrane “Polyunsaturated fatty acid for the prevention of allergy and food hypersensitivity” protocol submitted for review.

Gladman L-Greater Eastern & Southern Child Health Network (GESCHN) Paediatric feeding Clinical Practice Guidelines Working Party. Purpose: To provide clinical pathways for assessment and intervention for children with feeding problems requiring enteral (and enteral-oral) support. Guideline development has commenced

256 MENTAL HEALTH UNIT, MENTAL HEALTH ACADEMIC UNIT / SCHOOL OF PSYCHIATRY

DEPARTMENTAL STAFF*

Head of Department Dr Kevin Clarke MBBS(Hons), MHA, Grad Dip FBS, FRANZCP Conjoint Lecturer UNSW

Professor Colleen Loo (MB.BS. (Hons), FRANZCP, MD.; Professor – School of Psychiatry UNSW; Research Psychiatrist – Black Dog Institute)

Dr Matthew Boulton BMBS BSc FRANZCP Psychiatrist – PECC Conjoint Associate Lecturer UNSW

Dr Anne Camac MBBS, FRANZCP Conjoint Lecturer UNSW

Dr Mesut Cetiner MBBS Bsc (Med) (Hons) FRANZCP Certiﬁcate POA & Conjoint Lecturer UNSW

Dr Denise Cupina MD, FRANZCP Conjoint Senior Lecturer UNSW

Dr Spencer Duke BMedSci BM BS MRCPsych FRANZCP Conjoint Senior Lecturer UNSW

Dr Andrew Gerard MBBS FRANZCP

Dr Peter Jones MBChB MRCPsych FRANZCP

Dr Andrew Kaill BMED FRANZCP TA

257 Dr Yana Kay MBBS, BA, PHD FRANZCP Conjoint Lecturer UNSW

Dr Andrew Pethebridge MBBS, MM (Ven Sci), MM, FRANZCP, FAChAM Conjoint Senior Lecturer UNSW

Dr Margot Phillips BABSc (Med) MBBS FRANZCP

Vocational Registrars, Advanced Trainees Dr Roslyn Lai (MBBS, MD) - 2011

Senior Research Staff Dr Angelo Alonzo (BA, BSc (Hons), Ph.D) Dr Donel Martin (MClinNeuroPsych; PhD), BA (Hons); MClinNeuroPsy

Research Assistants Natalie Katalinic (BA (Hons)

Research Students Michael Player (BPsych (Hons), Ph.D) Varsha Sivalingham (ILP) Rose Liu (ILP) Natalie Johnston (BSc, MB BS)

Nursing & Allied Health Research Staff Dr Grace Chan (BA Nursing), PhD)

258 RESEARCH GRANTS#

Category I - Nationally Competitive Grants

NHMRC Project Grant ID 510142 - A Sham-controlled Study of Transcranial Direct Current Stimulation (tDCS) as a Treatment for Depression. Professor Colleen Loo $400,500 (2008-2010)

NHMRC Project Grant ID 568678 - A controlled study of bilateral electroconvulsive therapy Professor Colleen Loo, Professor Isaac Schweitzer $421,268 (2009-2011)

NHMRC Project Grant ID 1004152 – Role of neurogenesis in clinical recovery from depression during ECT: Application of a novel in vivo magnetic resonance spectroscopy technology. Dr Michael Valenzuela, Professor Colleen Loo, Dr Jesus Pujol, Professor Petar Djuric, Dr Dennis Velakoulis, Associate Professor Murat Yucel, Professor Mike Dragunow $505,312 (2011-2013)

NARSAD young Investigator Award – Remediation of cognitive dysfunction in euthymic bipolar disorder patients using transcranial direct current stimulation (tDCS) Dr Donel Martin $60,000 USD (2011-2012)

Category II - Other competitive grants

Category III – Industry and other research funding: UNSW Gold Star Award. Outcomes of Standard and Ultrabrief Pulsewidth ECT. Professor Colleen Loo $40000 (2010)

UNSW Gold Star Award. A comparative study of two forms of ECT: standard and ultrabrief pulsewidth. Professor Colleen Loo $40000 (2011)

UNSW Gold Star Award. A controlled trial of ketamine as an adjunctive agent in ECT. Professor Colleen Loo $40000 (2011)

UNSW Early Career Faculty Research Grant – The effect of timing of transcranial direct current stimulation (tDCS) for enhancing learning during cognitive training. Dr Donel Martin $17,000 (2011)

259 RESEARCH PROJECTS IN PROGRESS

Title Investigators

A controlled study of ultrabrief pulsewidth ECT Professor Colleen Loo, Professor Isaac Schweitzer

An effectiveness trial assessing the efﬁcacy and cognitive side effects of BT, Professor Colleen Loo, Dr Bill Lyndon BF and RUL ECT

A double-blind, randomised, placebo-controlled study of adjunctive Professor Colleen Loo, Associate Professor Ross ketamine anaesthesia in ECT (electroconvulsive therapy) MacPherson, Dr Ron Woodey, Dr Bill Lyndon

Validation of a new in vivo MRI approach for measurement of Dr Michael Valenzuela, Professor Colleen Loo hippocampal neurogenesis in humans

Genetic factors, biomarkers, and outcomes in ECT Professor Colleen Loo

A sham-controlled study of transcranial direct current stimulation (tDCS) Professor Colleen Loo, Professor Philip Mitchell, as a treatment for depression Professor Perminder Sachdev, Melissa Pigot

Professor Colleen Loo, Prof Phil Mitchell, Open pilot trial of transcranial direct current stimulation (tDCS) using Prof Perminder Sachev, Dr Donel Martin, alternative electrode montages. Dr Angelo Alonzo Professor Colleen Loo, Prof Phil Mitchell, Prof Investigating methods to enhance the excitatory effects of transcranial Perminder Sachev, Dr Donel Martin, Dr Angelo direct current stimulation (tDCS). Alonzo Professor Colleen Loo, Prof Phil Mitchell, Investigating methods to enhance the excitatory effects of transcranial Prof Perminder Sachev, Dr Donel Martin, direct current stimulation (tDCS). Dr Angelo Alonzo

Professor Colleen Loo, A/Prof Janet Taylor, Comparison of measures of plasticity Prof Perminder Sachev, Michael Player

Genetic Factors, Biomarkers and Outcomes of Brain Stimulation Professor Colleen Loo

Professor Colleen Loo, Prof Phil Mitchell, Prof A study of transcranial electrical stimulation Perminder Sachdev, Dr Donel Martin, Dr Angelo Alonzo Professor Colleen Loo, Dr John Leyden, Dr Simon A study of ketamine as an antidepressant Harper, Dr Jenny McGoldrick, Dr Jarrett Johnston, Dr Harry Wark, Natalie Katalinic, Dr Grace Chan

Open Pilot Trial of Temporal Lobe Transcranial Direct Current Stimulation Professor Colleen Loo, Dr Angelo Alonzo, (tDCS) for Depression Dr Donel Martin

Professor Colleen Loo, Professor Philip Mitchell, Investigating Direct current Stimulation as a Treatment for Depression: A Professor Perminder Sachdev, Dr Angelo Alonzo, Controlled Clinical Trial Dr Donel Martin

Enhancing cognitive training using transcranial direct current stimulation Dr Donel Martin, Professor Colleen Loo, (tDCS): a randomised controlled trial. Dr Melissa Green

The Effect of Timing of Transcranial Direct Current Stimulation (tDCS) for Dr Donel Martin, Professor Colleen Loo, Enhancing Learning During Cognitive Training Dr Melissa Green, Dr Angelo Alonzo

Dr Donel Martin, Professor Colleen Loo, Remediation of Cognitive Dysfunction in Euthymic Bipolar Disorder Patients Dr Melissa Green, Professor Philip Mitchell, Using Transcranial Direct Current Stimulation (tDCS): A pilot study Dr Angelo Alonzo

Neuroplasticity induced by transcranial direct current stimulation Professor Colleen Loo, Dr Janet Taylor, treatment. Michael Player

260 This report was compiled by Please support your local medical research foundation