Research >Report St George and Sutherland Hospitals 2012 » 2013 > introductions

Professor John Edmonds Conjoint Professor, UNSW Chair of the St George and Sutherland Medical Research Foundation

The Research Report of the St George and Sutherland Hospitals, currently published every second year, is an important record of our clinical and research staff and some traditional indicators by which institutions’ research status is judged: projects undertaken, grants awarded, publications and presentations. There are encouraging pointers, great and small, that government and society are increasingly recognising the importance of medical research: McKeon’s Strategic Review of Health and Medical Research; a federal commitment to a 20 billion dollar medical research fund; the choice of Suzanne Corey (former Director of WEHI) as the 2014 Boyer Lecturer; even a recent Q & A session devoted to Science & Australia. As society looks to its great academic medical centres for research-driven guidance, it becomes ever more important that St George and Sutherland Hospitals match the excellence of their clinical service and teaching with a comparable level of eminence in research endeavour and success. The St George and Sutherland Medical Research Foundation is committed to helping the hospitals’ academics in that project. The Research Reports provide a useful audit of our joint progress.

Professor Peter Gonski Head, Sutherland Teaching Unit St George Clinical School

Although Sutherland Hospital is well known as a provider of major clinical service to the South Eastern Sydney Local Health District, it also provides a major teaching resource to medical, nursing and allied health students. Research is now becoming important in its activities. On behalf of Sutherland, I am grateful that the St George and Sutherland Medical Research Foundation has included us in their activities and also providing research funds. With the close relationships between the hospital, community, Universities and Foundation, which have already been secured, I can only see the research interest increase in the future. I do think that our significant clinical load allows us to be leaders in clinical research and assure that our research will directly influence patient care and lives. It is wonderful to have our research celebrated in this report. Professor Ritin Fernandez Professor of Nursing

Research and Innovation is vital to the provision of quality healthcare for our patients. At St George Hospitals clinician and scientists undertake the full spectrum of basic biomedical, clinical and health services research. There has been a remarkable progress in research outputs and outcomes at St George Hospital and this report high lights the unique and influential research that is being conducted by our world class researchers. The report also demonstrates the commitment of researchers and scientists not only towards evidence synthesis but also in translating and implementing the evidence in clinical practice.

I would like to acknowledge the role and contribution of the broader hospital community, our patients, the many volunteers, our collaborators and supporters, particularly the St George and Sutherland Medical Research Foundation without whom research here would not be possible. The research achievements are very encouraging, but more importantly they form the foundation for future research endeavours as well as provide inspiration and motivation as we move forward.

Professor Michael Grimm Clinical Associate Dean St George Clinical School, UNSW

Research in our hospitals fundamentally supports the excellence in clinical care for which we all strive. If anything, this will become even more important in coming years. This important report demonstrates the extraordinary breadth and impressive depth of research activities undertaken at St George and Sutherland Hospitals, and I hope it serves to announce those achievements loudly and emphatically.

The composing of a document such as this always comes as a surprise: surprise at the breadth and volume of research carried out by hospital and university staff and students, from most senior to undergraduate levels. It’s a testament to the enormous amount of hard work that goes into making our hospitals vital and inquiring places, as well as places of healing.

I commend this report to all members of our hospital communities. > Contents

Medicine And Critical Care 5 Mental Health 109

Cardiology 6 Mental Health Academic Unit, School of Psychiatry 110 Dermatology 8 Emergency – St George Hospital 15 Women’s and Children’s Health 115 Emergency – The Sutherland Hospital 18

Endocrinology 19 Urogynaecology 116 Gastroenterology and Hepatology 22 Women’s Health 119 Infectious Disease, Immunology and 27 Sexual Healh Nursing and Midwifery 127 Intensive Care – St George Hospital 31 Nuclear Medicine 41 Centre for Research in Nursing and Health 128 Renal Medicine 42 Respiratory and Sleep Medicine 47 South Eastern Sydney Laboratory 136 Services Rheumatology 49 Anatomical Pathology 137 Cancer Services 52 Aged and Extended Care 139 Haematology 53 Medical Oncology 61 Aged Care St George Hospital 140 Palliative Care 69 Rehabilitation Medicine 141 Radiation Oncology 79 Southcare The Sutherland Hospital 142

Surgery, Perioperative And Anaesthetic 82 Allied Health 143 Services Nutrition and Dietetics 144 Anaesthesia 83 Occupational Therapy 146 Cardiothoracic Surgery 85 Physiotherapy 147 Liver and Periotonectomy Surgery 90 Speech Pathology 148 Orthopaedic Surgery 96

Trauma 104 Erratum 151 Vascular Surgery 108 MEDICINE AND CRITICAL CARE

Cardiology > 6 Renal Medicine > 42

Dermatology > 8 Respiratory Medicine > 47

Emergency – Rheumatology St George Hospital > 15 > 49

Emergency – > Sutherland Hospital 18

Endocrinology > 19

Gastroenterology and > Hepatology 22

Infectious Disease, Immunology and Sexual > 27 Health

Intensive Care – > St George Hospital 31

Nuclear Medicine > 41 > Department of Cardiology

Head of Department Lead in the clinical MRI (Magnetic Resonance Imaging) environment, Dr Andrew Hopkins. Dr Mark Sader MBBS(Hons) PhD A Multicentre, Randomised, Double blind, Placebo- Senior Medical - Staff Specialists Controlled Study to Evaluate the Safety and Efficiency of Dr David Ramsay study drug in Addition to Standard of Care in subjects with Dr David Rees Acute Coronary Syndrome. Thrombin Receptor Antagonist Dr Andrew Hopkins in Acute Coronary Syndrome, Dr Ananth Prasan. Dr Maurits Binnekamp A Phase 3, Randomised, Double-Blind, Evaluation of the Dr Ananth Prasan Safety and Efficiency of study drug In Subjects with a Dr George Youssef recent ACS, Dr. Ananth Prasan. Dr James Weaver BSc Med MBBS(Hons) PhD Dr Queenie Lo Trial Evaluating CV Outcomes with study drug in patients Dr Victar Hsieh with Type 2 Diabetes, Dr. Maurits Binnekamp.

Research Staff A randomized, double-blind, placebo-controlled, event driven trial of quarterly subcutaneous canakinumab in Deborah Vrachas – CNS the prevention of recurrent cardiovascular events among Glenn Paull - CNC stable post-myocardial infarction patients with elevated Research Projects in Progress hsCRP, Dr George Youssef.

A bone marrow-derived Stro3 mesenchymal precursor Original Peer-Reviewed Publications cells (MPC) in the treatment of patients with ST-elevation Rayner BS, Figtree GA, Sabaretnam T, Shang P, Mazhar J, myocardial infarction, Dr. Ananth Prasan. Weaver JC, Lay WN, Witting PK, Hunyor SN, Grieve SM, A Double-blind, Randomized, Placebo-controlled, Khachigian LM, Bhindi R. Selective Inhibition of the Master Multicenter Study Assessing the Impact of Additional Regulator Transcription Factor Egr-1 Using Catalytic LDL-Cholesterol Reduction on Major Cardiovascular Oligonucleotides Reduces Myocardial Injury and Improves Events When AMG 145 is Used in Combination With Statin Left Ventricular Systolic Function in a Preclinical Model Therapy In Patients with Clinically Evident Cardiovascular of Myocardial Infarction. Journal of the American Heart Disease, Dr. Ananth Prasan. Association. 2013; 2 (4):e000023. PMID 23902638.

Prevention of contrast-induced acute kidney injury In Sorensen R, Paull G, Magaan L, Davis JM (2013). people undergoing angiogram, Dr. Ananth Prasan. Managing between the agendas - implementing health care reform policy in an acute care hospital. Journal of TIGRIS Study data collection 1-3yr post MI patients, Dr Health Organization and Management; 27 (6) 698-713. Mark Sader Presentations at Scientific Meetings and Study to evaluate Cardiovascular Outcomes Following Conferences Treatment with study drug in Addition to Standard of Care in Subjects with Type 2 DM and ACS, Dr. Ananth Prasan. 2012 International

Thromectomy VS PCI alone in STEMI patients, Dr James Sorensen R, Paull G, Magaan L, Davis JM. Is poor quality Weaver. of care built into the system? Evidence from a study on communication among teams treating people dying in The Advisa MRI System study is a prospective, randomised hospital wards. 8th International Organisational Behaviour controlled, non-blinded, multi centre worldwide in Healthcare Conference - Patient-centred healthcare investigational study, Dr Andrew Hopkins. teams: achieving collaboration, communication and care. Dublin, Ireland. To confirm safety and effectiveness of the Model 5076

6 2012 National

Paull G, Gallagher R, Horvath R, Chen D. Discrimination and high sensitivity cardiac troponin: the relationship between clinical presentation, clinical request and discharge diagnosis. 60th Annual Scientific Meeting of Cardiac Society of Australia and New Zealand, Brisbane.

Chandrasekhar J, Paull G, Youssef G, Weaver J, Rees D. Single Centre Clinical Experience and Discharge planning using high sensitivity troponin T post Elective PCI. 60th Annual Scientific Meeting of Cardiac Society of Australia and New Zealand, Brisbane.

Davis S, Paull G, Vuong N, Connolly B, Ang E. ICD’s and PTSD: a shocking story - from crisis to recovery. Australian Cardiovascular Health and Rehabilitation Association Annual Conference, Brisbane.

Paull G. Chronic Disease Self-management: Multilingual Audiovisual Resources for People with Ischaemic Heart Disease and Chronic Heart Failure. Australasian Cardiovascular Nursing College Annual Scientific Meeting, Sydney.

2013 National

Arndt M, Paull G. Living Well with Heart Failure: a role for Occupational Therapy in the management of chronic heart failure. Australian Cardiovascular Health & Rehabilitation Association Annual Scientific Meeting – Melbourne. > Department of Dermatology

Head of Department 2012-Jan 2013 Julie Dandenooy, Medical resident, Antwerp University, *Dedee F Murrell MA(Cambridge) BMBCh (Oxford) FAAD Belgium, Oct-Nov 2012; now Dermatology registrar (USA) MD (UNSW) FACD Conjoint Professor, Faculty of Medicine UNSW Research Staff/Students Supervised

Senior Medical Senior

Visiting Medical Officers Lizbeth Ruth A Intong MD FPDS Post dermatology *Anthony J Cronin MBBS (Syd) PhD (Cambridge) FACD research fellow; now FACD *Mei-Heng Tan MBBS (Syd) FAAD (USA) Junior Sabbaticals Benjamin S Daniel B.Com, MBBS- Predermatology M.Tariq Khan PhD (London) M Pod (UK), from Great research fellow-2011-12 Ormond St Hospital, Visiting Fellow, UNSW 2011-14 Research Students Research Fellows Wenfei Yan MD China- completed PhD (UNSW) 2012; post Dr Clarisse G Mendoza (Honorary VMO and Research Doc 2013; Fellow Supriya Venugopal MBBS – p/t PhD student; Mae Ramirez MD FBDS (Honorary VMO and Research Heather Cohn, MD PhD Postdoc on America Australia Fellow Association grant Jaehwan Kim MD PhD (Honorary VMO and Research Clement Loh (Honours research student)- High distinction Fellow Nursing Research Joni Lazo Dizon MD FPDS (Honorary VMO and Research Fellow Lesley M Rhodes RN CNC for Epidermolysis Bullosa Jackie Cochrane RN Charmaine Peras RN Lesley M Rhodes RN Independent Learning Project Students Margaret Norris RN

Junior Medical Jessica Davey Anh Tran (distinction) *Unaccredited dermatology registrars: Charles Wang Bonnie Fergie MBBS (UWA) 2012 *Funded by St George Hospital; rest from external Robert George MBBS (Otago) M Surg (U Syd) 2013 sources.

Visiting Dermatologists to St George/Premier Specialists Research Grants

William Hoang, Wake Forest University, NC, USA, 2012 NHMRC Project Grant: Investigation of flightless-1 in (WDS grant) epidermolysis bullosa. Allison Cowin, Ruth Arkell, Dedee Nancy Todes Taylor, San Francisco, Kaiser Permanente Murrell. $517,500, 2009-12. 2012 Grant from DebRA Australia, Dedee Murrell. $12,000, Visiting Dermatology Mentee Observers 2012/2013.

Michele Ramien, Derm Registrar, Univ of Ottawa, Jan-Feb Grant for Biologics Clinic, Abbott Pharmaceuticals, Dedee 2012 Murrell , $15,000, 2012/2013. Sang Hee Lee, Derm Registrar, Yonsei University College of Medicine, Seoul, Korea, May 2012 Donation for EB Research from Caroline Quinn Trust Fund, Herm Maartens, Derm Registrar, Masstricht University, Oct Dedee Murrell $25,000, 2012/2013. 8 Research Projects in Progress Daniel BS, Murrell DF, Joly P. Rituximab and its use in autoimmune blistering disorders. Immunol Allergy Clin Responsiveness of a quality of life instrument for North Am. 2012 May;32(2):331-7. autoimmune blistering diseases, the ABQOL we developed; Dedee Murrell, Renette Ang, Melanie Doria, Murrell DF Autoimmune diseases of the skin. Immunol Cathy Zhao. Allergy Clin North Am. 2012 May;32(2):xiii-xiv.

International validation of the QOLEB, the qualify of life Ng YZ, Pourreyron C, Salas-Alanis JC, Dayal JH, Cepeda- measure we developed and published for Australian Valdes R, Yan W, Wright S, Chen M, Fine JD, Hogg FJ, patients with EB; Dedee Murrell and various international McGrath JA, Murrell DF, Leigh IM, Lane EB, South AP. investigators. Fibroblast-derived dermal matrix drives development of aggressive cutaneous squamous cell carcinoma in patients Outcomes of pregnancies in EB; Murrell DF, Intong LRA, with recessive dystrophic epidermolysis bullosa. Cancer Choi DS, Rhodes LM, Walton J, Chapman M. Res. Jul 15;72(14):3522-34, 2012.

Role of flightless-1 in EB and EBA; Kopecki Z, Murrell DF, Wriston CC, Rubin AI, Martin LK, Kossard S, Murrell DF. Cowin, A. Plaque like cutaneous mucinosis. Am J Dermatopathol. 2012 Jun;34(4):e50-4. AIBD Registry; Dermawan A, Intong LRA, Murrell DF. Daniel BS, Murrell DF. Intravenous immunoglobulin: Epidemiology of Anaemia in EB; Hwang S, Daniel BF, recent advances in the treatment of autoimmune bullous Murrell DF. diseases. J Ital Dermatol Venereol. 2012 Jun;147(3):259- Epidemiology of renal impairment in EB; Murrell DF. 67.

Original Peer-Reviewed Publications Hwang S, Kim MH, Kemble Welch A, Hanley MC, Murrell DF. Volunteering at an adventure camp for epidermolysis Intong LRA, Murrell DF: Inherited EB: New diagnostic bullosa. Med J Aust. 2012 2012 Jul 5;197(1):54. criteria and classification. Clin Dermatol. 2012 Jan- Feb;30(1):70-7. doi: 10.1016. Schmitt J, Spuls P, Boers M, Thomas K, Chalmers J, Roekevisch E, Schram M, Allsopp R, Aoki V, Apfelbacher Sarig O, Bercovici S, Zoller L, Goldberg I, Indelman M, C, Bruijnzeel-Koomen C, Bruin-Weller M, Charman C, Nahum S, Israeli S, Sagiv N, Martinez de Morentin H, Katz Cohen A, Dohil M, Flohr C, Furue M, Gieler U, Hooft O, Baum S, Barzilai A, Trau H, Murrell DF, Bergman R, L, Humphreys R, Ishii HA, Katayama I, Kouwenhoven Hertl M, Rosenberg S, Nöthen MM, Skorecki K, Schmidt W, Langan S, Lewis-Jones S, Merhand S, Murota H, E, Zillikens D, Darvasi A, Geiger D, Rosset S, Ibrahim SM, Murrell DF, Nankervis H, Ohya Y, Oranje A, Otsuka H, Sprecher E. Population-Specific Association between a Paul C, Rosenbluth Y, Saeki H, Schuttelaar ML, Stalder Polymorphic Variant in ST18, Encoding a Pro-Apoptotic JF, Svensson A, Takaoka R, Wahlgren CF, Weidinger S, Molecule, and Pemphigus Vulgaris. J Invest Dermatol. Wollenberg A, Williams H. Towards global consensus on 2012 Mar 22. doi: 10.1038/jid.2012.46 outcome measures for atopic eczema research: results of the HOME II meeting. Allergy. Sep;67(9):1111-7, 2012. Venugopal SS, Murrell DF. Diagnosis and clinical features of pemphigus vulgaris. Immunol Allergy Clin North Am. Daniel BS, Skowronski G, Myburgh J, Hersch M, Murrell 2012 May;32(2):233-43. DF. Concurrent Management of Toxic Epidermal Necrolysis with Thermal Water Spray and non-stick dressings. Acta Frew JW, Murrell DF. Corticosteroid use in AIBD. Immunol Dermatol Croat; 20(3):210-212,2012. Allergy Clin North Am. 2012 May;32(2):283-94. Sebaratnam DF, Venugopal SS, Frew JW, McMillan JR, Chee SN, Murrell DF.Use of Intravenous immunoglobulin Finkelstein ER, Martin LK, Murrell DF. Diffuse melanosis in autoimmune blistering diseases. Immunol Allergy Clin cutis: a systematic review of the literature. J Am Acad North Am. 2012 May;32(2):323-30. Dermatol.

9 2012 Dec 5. doi:pii: S0190-9622(12)00901-2. 10.1016/j. Bullosa in Mexico: Cross Cultural Validation of the Hispanic jaad.2012.08.018.1. Version of the Quality of Life in Epidermolysis Bullosa Questionnaire. J Am Acad Dermatol 2013 69(4) 652-63. Kopecki Z, Ruzehaji N, Turner C, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin AJ. Topically applied Venugopal SS, Yan W, Frew JW, Cohn HI,Rhodes LM, Flightless I neutralising antibodies improve healing of Tran K, Melbourne W, Nelson JA, Sturm M, Fogarty J, blistered skin in a murine model of epidermolysis bullosa Marinkovich MP, Igawa S, Ishida-Yamamoto A, Murrell acquisita. J Invest Dermatol 6th Dec 2012 doi:10.1038/ DF. A phase II randomized vehicle controlled trial of jid.2012.457. intradermal allogeneic fibroblast therapy for recessive dystrophic epidermolysis bullosa. J Am Acad Dermatol Chow HT,Tran K, Millar E, Lynch J, Murrell DF. Diverse Sep 24 2013. doi:pii: S0190-9622(13)00864-5. 10.1016/j. Presentations of Carcinoma Erysipelatoides to a teaching jaad.2013.08.014 . hospital in Australia. Case Reports in Dermatological Medicine. 2012;2012:134938. doi: 10.1155/2012/134938. Tjokrowidjaja A, Daniel BS, Frew JW, Sebaratnam DF, Epub Dec 23. Hanna AM, Chee SN, Dermawan A, Wang CQ, Lim C, Venugopal SS, Rhodes LM, Welsh B, Nijsten T, Murrell Kim MH, Li M, Intong LRA,Tran K, Melbourne W, Marucci DF. The development and validation of the TABQOL, a D, Bucci J, de Souza P, Mallesara G, Murrell DF: Use of tool to measure the quality of life impacts of treatments cetuximab as an adjuvant agent to radiotherapy and used in patients with autoimmune blistering disease. Br surgery in Recessive Dystrophic Epidermolysis Bullosa with J Dermatol published online 31 Oct 2013 DOI: 10.1111/ Squamous Cell Carcinoma. Br J Dermatol 2013 Feb 12. bjd.12623 with accompanying editorial by Andrew Finlay doi: 10.1111/bjd.12272. mentioning its significance.

Ramirez M, Murrell DF, Fine JD. Management of Loh CH, Kim J, Su JC, Daniel BS, Venugopal SS, Rhodes Epidermolysis Bullosa Exp Opin Orph Drugs. Apr 2013, LM, Intong LRA, Law MG and Murrell DF. Development, Vol. 1, No. 4, Pages 279-293. Reliability and Validity of a novel Epidermolysis Bullosa Daniel BS, Murrell DF, Borradori L. Management of Bullous Disease Activity and Scarring Index (EBDASI). J Am Acad Pemphigoid. Exp Opin Orph Drugs. May 2013, Vol. 1, No. Dermatol 2014 Jan;70(1):89-97. 5, Pages 405-412. Brennan F, Murrell DF: Report from the Inaugural Pruritus Tong PL, Qin J, Cooper CL, Lowe PM, Murrell DF, Symposium, Sydney, Australia, 10th August 2013. Acta Kossard S, Ng LG, Roediger B, Weninger W, Haass NK. A Derm Venereol. 2013 Oct 24. doi: 10.2340/00015555- quantitative approach to histopathological dissection of 1732. elastin-related disorders using multiphoton microscopy. Br Sebaratnam DF, Venugopal SS, Murrell DF: Development J Dermatol. 2013 May 11. doi: 10.1111/bjd.12430. of an excel spreadsheet to document activity in Daniel BS, Murrell DF. Complete resolution of chronic autoimmune bullous diseases. Acta Dermatovenerol Croat. multiple verruca vulgaris treated with quadrivalent 2013 Oct;21(3):207-8. human papillomavirus vaccine. JAMA Dermatol. 2013 Dayal J, Cole C, Pourreyron C, Watt S, Lim Y, Salas-Alanis Mar;149(3):370-2. doi: 10.1001/jamadermatol.2013.1463. J, Murrell DF, McGrath J, Steiger B, Jahoda C, Leigh Kim J, Loh CH, Murrell DF. Epidermolysis bullosa I, and South AP. Type VII collagen regulates tumour pruriginosa triggered by scabies infestation J Dermatol. expression of organic anion transporting polypeptide 2013 May 10. doi: 10.1111/1346-8138.12167. OATP1B3, promotes front to rear polarity and increases structural organisation in 3D spheroid cultures of recessive Murrell DF: The pitfalls of skin biopsies for the diagnosis dystrophic epidermolysis bullosa tumour keratinocytes. J of epidermolysis bullosa Pediatr Dermatol. 2013 Mar- Cell Sci (Dec 2013 e pub). Apr;30(2):273-5. doi: 10.1111/pde.12095 Murrell DF, Amagai M, Werth VP: Why bother with scoring Sebaratnam DF, Hanna AM, Chee SN, Frew JW, systems for blistering diseases in practice and which one Venugopal SS, Daniel BS, Martin LK, Rhodes LM, Tan JC, should you use? Invited editorial. JAMA Dermatol 2014 Wang CQ, Welsh B, Nijsten T, Murrell DF. Development Jan 15. doi: 10.1001/jamadermatol.2013.8179. of a Quality-of-Life Instrument for Autoimmune Bullous Disease: The Autoimmune Bullous Disease Quality of Life Yuen QY, Frew JW, Veerman K, Van den Heuvel ER, Questionnaire.JAMA Dermatol. JAMA Dermatol. 2013 Murrell DF, Jonkman MF: Health related quality of life in Oct;149(10):1186-91. epidermolysis bullosa: validation of the Dutch QOLEB Questionnaire and assessment in the Dutch population. Frew JW, Cepeda-Valdes R, Fortuna G, Murrell DF, Acta Derm Venereol 2013 Dec 12. doi: 10.2340/00015555- Salas-Alanis J: Measuring Quality of Life in Epidermolysis 17582013. 10 Kopecki Z, Yang GN, Arkell RM, Jackson JE, Melville Presentations at Scientific Meetings and E, Iwata H, Ludwig RJ, Zillikens D, Murrell DF, Cowin Conferences AJ: Flightless I overexpression impairs skin barrier development, function and recovery post skin blistering. J 2012 Pathol Dec 28, 2013 e pub. DOI 10.1002/path 4323. Professor D. Murrell

Other published material American Academy of Dermatology, San Diego, March Up to date: DF Murrell invited author for 4 chapters, 2012, 2012, Autoimmunity forum – what’s new in autoimmune with biannual updates: bullous diseases - invited lecture

Murrell, DF. ICD-11 – section on definitions and Stanford University – Epithelial Biology Marinkovich Lab, descriptions of Epidermolysis Bullosa 2012 March 2012, Allogeneic cultured fibroblast therapy for recessive dystrophic epidermolysis bullosa - invited lecture Murrell, DF, Textbook: Blistering Diseases. Springer Verlag. In process, 2013. American Academy of Dermatology, Boston, MA, August 2012, Forum on AIBD – Complex cases - invited lecture Murrell DF, Cases in Blistering Diseases. Elsevier, book, 2013. NSW Dermatology Nurses Association, August 2012, Management of autoimmune blistering diseases- invited Daniel BS, Murrell DF. Epidermolysis Bullosa. In: Clinical lecture Genomics: Practical Applications in Adult Patient Care. GP education evening, St George Area, August 2012. Skin McGraw Hill and American College of Physicians, 2013, manifestations of systemic disease. 80 GPs. Sponsored by chapter 110. Stiefel/GSK - invited lecture

Sebaratnam DF, McMillan JR, Werth V, Murrell DF: Quality Continental Congress of Dermatology, Durban, South of life in patients with bullous dermatoses. Clinics in Derm Africa, Oct 2012, 3 invited lectures Jan;30(1):103-7. doi: 10.1016/j.clindermatol.2011.03.016., Management of lupus in women – Maria Duran 2012. sympsosium - Epidermolysis Bullosa – what’s new? Pemphigoid – what’s new? Daniel BS, Hertl M, Werth VP, Eming R, Murrell DF: Severity Score Indexes for blistering American Academy of Dermatology, San Diego, CA, diseases. t, Jan;30(1):108-13, 2012 doi: .1016/j. March 2012 clindermatol.2011.03.017. Chair, Forum on Management of Epidermolysis Bullosa Speaker - Pathogenesis of squamous cell carcinoma in EB Kim MH, Intong LRA, Murrell DF: Epidermolysis bullosa and squamous cell carcinoma. In: Squamous Cell Speaker - What’s new in autoimmune blistering diseases. Carcinoma, Editor: Daniel V. Mortensen. Nova Publishers, Co-chair, First Inernationall Consensus meeting on EBA Ch 5:107-122, 2012. ISBN: 978-1-61209-929-3. 3rd World Congress of Dermoscopy – Brisbane, QLD, May Fergie BF, Intong LRA, Murrell DF: Management 2012. Chair, Women’s Dermatologic Society networking strategies for epidermolysis bullosa acquisita. In Update reception. in dermatologic drug therapy, edited by Jasna Lipozencic. Published by the Academy of Medical Sciences of Croatia, Australasian College of Dermatologists Meeting, Brisbane, Zagreb, 2012. ISBN 978-953-6868-39-1. Chapter 21, pp QLD, May 2012 245-253. Plenary speaker – ERIVANCE phase II trial for advanced BCC Frew JW, Murrell DF: An update on the use of Speaker - Consensus definitions and scoring for Bullous corticosteroids in autoimmune blistering diseases. In Pemphigoid. Update in dermatologic drug therapy, edited by Jasna Lipozencic. Published by the Academy of Medical American Academy of Dermatology Summer Meeting, Sciences of Croatia, Zagreb, 2012. ISBN 978-953-6868-39- Boston, Aug 15-19, 2012 1. Chapter 22, pp 254-268. Chair- Forum on Difficult cases in bullous diseases Continental Congress of the International Society of Loh CH, Kim J, Murrell DF: Urticaria. In: Australian Doctor Dermatology, Durban, S. Africa, Oct 25-29, 2012. How to Treat Yearbook 2013, pp 213-218. Editor: S. Liang. Chair, Blistering Diseases Symposium Publisher: Craft Print, Singapore. Speaker, Paediatric Dermatology – what’s new in EB therapies Speaker, Maria Duran Symposium- Management of lupus in women and children. 11 Grading of Registrar presentations & presentation of treatment of Pemphigus, Shiraz University Hospital- 17th awards at opening ceremony June.

Epidermolysis triennial research conference (invitation 3rd Munich International Summer Academy of Practical only); Marbella, Spain, Nov 4-7, 2012. Invited speaker – Dermatology, July 2013 scoring systems for EB Invited speaker – diagnosis and management of lupus (plenary) Australasian Society for Dermatological Research, Sydney, WDS speaker - hedgehog inhibitors for advanced and NSW May 22-24, 2012 metastatic BCC. Murrell DF, Convenor of the ASDR conference World Congress of Paediatric Dermatology, Madrid, Spain, Venugopal S, Yan WF, Frew JW, Murrell DF: Randomized Sept 25-29, 2013 controlled trial of cell therapy for RDEB. Invited Chair – blistering diseases in children Venugopal SS, Rhodes LM, Welsh B, Nijsten T, Murrell DF: Speaker – neonatal autoimmune blistering disorders Validation of a the psychometric properties of a quality of Poster- validation of QOLEB in Brazilian Portuguese & of life measure specific to autoimmune bullous disease. EBDASI.

Kim MH, Li M, Intong RA, Tran K, Melbourne W, Marucci European Academy of Dermatovenereology, Istanbul, D, Inder S, Bucci J, De Souza P, Mallesara G, Murrell DF: Turkey, Oct -4-7, 2013 Use of cetuximab as an adjuvant agent to radiotherapy Chair- autoimmune blistering diseases and surgery in Recessive Dystrophic Epidermolysis Bullosa Speaker – Collagen VII spectrum disorders with Squamous Cell Carcinoma. Speaker - Validation of EBDASI scoring system Co-Chair- Women’s Dermatologic Society Rose Parade of 2013 Cases

Professor D. Murrell World Congress – International Society of Dermatology, New Delhi, India, Dec 2013 American Academy of Dermatology, Miami, USA, March Co-Chair & Speaker, Autoimmunity Symposium 2013 Invited Speaker, What’s New in treatment of genetic skin Chair, EB Management Forum; speaker on EB and diseases squamous cell carcinoma Member of the Scientific Committee Speaker - Biologics beyond psoriasis forum – rituximab Co-Chair, Women’s Dermatologic Society Rose Parade of Speaker – cell therapy for epidermolysis bullosa Cases Speaker – what’s new in epidermolysis bullosa. R. N. T Medical college, Udaipur,Rajasthan, India, Israeli Dermatology Society, Tel Aviv, April 24-26, 2013 December 12th, 2013, invited by Dr Asit Mittal, Evidence Invited keynote Speaker –plenary lecture- Evidence based based treatment of pemphigus. treatment of AIBD. Collaborative Presentations Bullous Disease Research meeting, Lubeck, Germany: Speaker - Scoring systems for AIBD; International Investigative Dermatology, Edinburgh, May Speaker - Consensus conference on EBA. 2013

Australasian Society for Dermatology Research, Sydney, Loh CH, Kim J, Su J, Daniel BS, Venugopal SS, Rhodes LM, May 2013 - Law M, Murrell DF. Development, Reliability and Validity Speaker - Translational therapies for EB of a Novel Severity Score for Epidermolysis Bullosa: the Speaker - Interim results from the STEVIE trial for Epidermolysis Bullosa Disease Activity and Scarring Index advanced and metastatic BCC. (EBDASI) (Presented by Clement Loh, Student).

Australasian College of Dermatologists, Sydney, May 2013 Tran AQT, Lazo-Dizon JP, Kim J, Daniel BS, Venugopal SS, Speaker – Understanding hedgehog inhibitors for Rhodes LM, Law MG, Murrell DF. Reliability study of four advanced and metastatic basal cell carcinomas. objective outcome measures for atopic dermatitis.

Iranian Society of Dermatology, (Profs Dowlati & Chams- Yan WF, Venugopal SS, Frew JW, Rhodes LM,, Melbourne Davatchi) June 2013- invited lectures W, Tran K, Murrell DF. Translocation of the cytokine University of Tehran, Research Institute of Dermatology, HMGB1 coincides with wound healing in fibroblast- What’s New in EB? 11th June injected wounds of Recessive Dystrophic Epidermolysis Evidence Based treatment in AIBD, Razi Hospital. 12th Bullosa. June Novel Specific Therapies for EB & Evidence based 12 Kopecki Z, Yang GN, Arkell RM, Jackson JE, Iwata More than skin deep, about our EB mission to Vietnam. H, Ludwig RJ, Zillikens, D, Murrell DF and Cowin Interview for “Tonic” on ABC TV news segment in health AJ. Flightless I overexpression impairs skin barrier report by Dr Norman Swan, regarding medical spa therapy development, function and recovery post-blistering. for atopic eczema, 8th Jan 2012. Tjokrowidjaja A, Daniel BS, Frew JW, Sebaratnam DF, Interview for A Current Affair on Channel 9, on the new Hanna AM, Chee S, Dermawan A, Wang CQ, Lim C, oral drug for basal cell skin cancer, Erivedge, due to the Venugopal SS, Rhodes LM, Cochrane J, Welsh B, Nijsten clinical trial we conducted and an interview of one of my TM, Murrell DF. The development and validation of the trial patients. Thursday February 2nd, 6.45pm, 2012. TABQOL, a tool to measure the quality of life impacts of treatments used in patients with autoimmune blistering Conferences and Seminars Organized - Professor D. disease. Murrell

Australasian College of Dermatologists, Sydney, May 2013 Australasian Society for Dermatological Research Conference, Dockside Conference Centre, Darling Hwang SJ, Daveys J, Fergie B, Rhodes LM, Daniel BS, Harbour, May 22-24th, Sydney 2012, 250 registrants. Murrell DF. Prevalence and characterisation of anaemia in 8 international speakers. Fundraised for the meeting. patients with Epidermolysis Bullosa registered in Australia. Scientific program co-chair. Loh CH, Kim J, Su J, Daniel BS, Venugopal SS, Rhodes LM, International Society of Dermatology – Continental Law M, Murrell DF. Development, Reliability and Validity Congress. Durban, South Africa. Member of the Scientific of a Novel Severity Score for Epidermolysis Bullosa: the Committee. Oct 2 27th, 2012. Epidermolysis Bullosa Disease Activity and Scarring Index (EBDASI) (Presented by Clement Loh, Student). First Australasian Pruritus Conference, Aug 19th, St George Hosp, Sydney, with Dr Frank Brennan. Frew JW, Cepeda-Valdes R, Fortuna G. Salas-Alanis JC, Murrell DF. Cross Cultural Adaptation of the “Quality of International Society of Dermatology- World Congress. Life in Epidermolysis Bullosa” (QOLEB) Questionnaire: New Delhi, India. Member of Scientific Committee. Dec Validation and Results of Hispanic Translations. 4-7th, 2013.

Community Engagement 2013 Secured bid for Australia to host the 2021, International Congress of Dermatology, as Congress Australasian Blistering Diseases Foundation – Patient President, Int’l Society of Dermatology, Melbourne, support group meetings organized on St George Campus Australia, November 2021. (successful bid, in India, ICD and fundraising to support research into life threatening 2013) blistering diseases. Grant Reviewer - Prof DF Murrell, 2012-13 DebRA Australia – annual meeting in Melbourne to assist EB patients attending. Ludwig Boltzmann Gesellschaft, Austria – up to $1M Euros United States-Israel Binational Science Foundation 2011, Butterfly Day – fundraising for DebRA –front lobby of St grants up to $500K George Hospital. St George Hospital Medical Research Foundation 2012, Prof D. Murrell – seeing patients with blistering diseases 2013 and teaching abroad University of Modena – Reggio Emilia 2012 HKL, UPM, Islamic University, Kuala Lumpur, Malaysia - 4 PSI Foundation, Canada 2012 weeks Health Research Board, Ireland 2013 Medical mission to see patients and teach medical staff about Epidermolysis Bullosa in Vietnam: FV Hospital, Awards Ho Chi Min & National Paediatric Hospital, Hanoi, accompanied by EB nurse. Prof DF Murrell

Arranged visiting apprenticeship for Dr Thach Hoang, • Women’s Dermatologic Society, Mentor of the Year Pathologist, National Pediatric Hospital, Hanoi, Vietnam, Award, 2013 (Presented at the American Academy of to learn immunofluorescence mapping of Epidermolysis Dermatology, Miami, USA). Bullosa. • International League of Dermatologic Sciences Interviews with Media – Certificate of Appreciation for contributions to International Dermatology education and Front cover of Rotary Down Under Jan 2012 Issue 535: volunteerism.

13 Mae Ramirez

• Women’s Dermatologic Society and AAD International Travel Grant, 2012 to present our research at the AAD, Miami 2013.

• International Society of Dermatology Mentorship Grant to spend 3 months with Dr Antonella Tosti at the University of Miami, Florida, 2013.

Deshan Sebaratnam

• Medical Dermatology Society Mentorship Grant to validate our ABQOL measure in the USA at the University of Pennsylvania with collaborator Dr Victoria Werth.

• Brenan Prize, Australasian Society for Dermatopathology, for a project on BRAF mutations in diffuse melanosis.

Clement Loh

• Japanese Society for Investigative Dermatology award to present our research on the validation of a new score for EB at the International Investigative Dermatology meeting in Edinburgh, May 2013.

• Dean’s List Award for Research for his project on development and validation of the EBDASI 2013.

14 > Emergency Department, St George Hospital

Head of Department Three month outcome of patients with suspected acute coronary syndrome using point of care troponin testing Trevor Chan MB ChB, Dip Paeds, FACEM compared with laboratory based troponin testing: a Research Staff randomised trial. Asha SE, Cooke A, Walter E, Weaver J.

Stephen Asha, BSc, MBBS, FACEM, MMed(Clin Epi Benztropine for the relief of acute non-traumatic neck pain Director of Emergency medicine Research, Emergency – a randomised trial. Asha S, Kerr A, Jones K, McAlpine A. Department, St George Hospital Sensitivity and specificity of CT scanning for determining Senior Lecturer (Conjoint), UNSW the number of internally concealed packages in ‘body- Alana Clements, CNC packers’. Asha SE, Higham M, Child P. Allan Ajami NUM Accuracy of emergency physicians and trainees at Joanne Plowes CNS identifying internally concealed drugs on CT: do ‘lung Jacqui Fong NP windows’ improve accuracy. Asha SE, Cooke A. Kate Jarrett CNE Alison Berry CNS Does the implementation of a Chest Injury Protocol Bernadine Romero CNC (ChIP) for patients with blunt thoracic trauma reduce Margaret Fry CNC complications and improve outcome? Curtis K, Asha SE, Liz Walter CNS Unsworth A, Langcake M. Lauren Neuhaus NE Diagnostic utility of retinal vein pulsation on Megan Foreshew A/NUM ophthalmoscopy for predicting serious intra-cranial George Bayeh CNS pathology. Asha SE. Leanne Horvat SESLHD Emergency Stream Manager

Junior Medical Factors associated with in-hospital death among elderly patients sustaining a traumatic subdural haemorrhage. Andrew Cooke MBBS; DCH; LLB; LLM Asha SE, Keady J, Curtis K, Kohan, S. Rizwan Qureshi MBBS, MRCS Ed The effect of a nurse team leader on communication and Daniel Honneyman, MbChB leadership in major trauma resuscitations. Clements, A, Richard Pryor, MD, ABEM Curtis K, Horvat L, Shaban R. Research Projects in Progress Pre-Post test comparison of the impact of sepsis A Randomised Controlled Trial of Conservative versus guidelines in ‘time to antibiotics’ in one emergency Interventional Treatment of Primary Spontaneous department” Romero B, Horvat L and Fry M Pneumothorax. Australian New Zealand Clinical Assessment and management of the cognitively impaired Trials Registry (ANZCTR), registration number older person presenting to emergency departments with ACTRN12611000184976. Multicentre trial, Principal musculoskeletal conditions and injuries. Fry M, Arendts G, Investigator: Dr Stephen Asha. Chenoweth L, Macgregor C, Dee K, Vardell W Romero B. T3 Trial: Triage, Treatment and Transfer of Patients with Exploration of the insertion and use of peripheral IV stroke in Emergency Departments. Nursing Research cannulas in one emergency department. Romero B, Berry Institute, Australian Catholic University. Multicentre trial, A and Fry M. Principal Investigator: Dr Stephen Asha.

Asia, Australia and New Zealand dyspnoea in the Original Peer-Reviewed Publications Emergency Department Study. Co-ordinating investigator: 2012 Anne-Maree Kelly, Western Health, Victoria. Multicentre trial, Principal Investigator: Dr Stephen Asha. Asha SE, Curtis K, Grant N, Taylor C, Lo S, Compagnoni K. Comparison of radiation exposure of trauma patients

15 from diagnostic radiology procedures before and after the of motion of the cervical spine using a tape measure. introduction of a ‘panscan’ protocol. Emergency Medicine Journal of Manipulative and Physiological Therapeutics. Australasia 2012; 24: 43-51. (Editorial regarding this article 2013; 36(8): 538-545. published in same issue: Stengel, D. Rebalancing the Asha SE, Ajami A. Improvement in emergency department major trauma computed tomography pan-scan between length of stay using an early senior medical assessment panacea and pandora’s box. Emergency Medicine and streaming model of care: A cohort study. Emergency Australasia 2012;24: 1-3) Medicine Australasia. Published online first 2013 doi: Jamali S, Asha SE. Reproducibility of the seated reduction 10.1111/1742-6723.12128 technique for anterior shoulder dislocation when Arora M, Asha S, Chinnappa J, Diwan AD. Burnout in performed by doctors with minimal experience in the emergency Physicians – a review. Emergency Medicine technique. Emergency Medicine: open access. 2012; Australasia. 2013; 25(6): 491-5. 2:109 doi:10.4172/2165-7548.1000109 Fry M, Horvat L, Roche M, Fong J, Plowes J (2013) A Qureshi R, Asha SE, Zahra M, Howell S. Factors associated four month prospective descriptive exploratory study with failure to follow up with a general practitioner after of patients receiving antibiotics in one Emergency discharge from the emergency department. Emergency Department. International Emergency Nursing 21:163-167. Medicine Australasia. 2012; 24: 604-609. Fry M, MacGregor C, Ruperto K, Jarrett K, Wheeler J, Clements A, Curtis K (2012) What is the impact of nursing Fong J, Fetchet W (2013) Nursing praxis, compassionate roles in hospital patient resuscitation? Australasian caring and interpersonal relations: An observational study. Emergency Nursing Journal 15:108-115. Australasian Emergency Nursing Journal 16:37-44. Curtis K, Caldwell E, Delprado A, Munroe B (2012) Traumatic injury in Australia and New Zealand. Australasian Presentations at Scientific Meetings and Emergency Nursing Journal 15:45-54. Conferences

Fry M, Horvat L, Roche M, Fong J, Plowes J (2012) The 2012 – National prevalence and triage characteristics of patients presenting Qureshi R, Asha SE, Zahra M, Howell S.. Factors associated with infection to one tertiary referral hospital. Australasian with failure to follow up with a general practitioner after Emergency Nursing Journal 15:127-132. discharge from the emergency department. Evidence Fry M, Ruperto K, Jarrett K, Wheeler J, Fong J, Fetchet review in Emergency Medicine, November 2012, Terrigal, W (2012) Managing the wait: Clinical initiative nurses’ NSW. perceptions of an extended practice role. Australasian Nichols M, Acker J, Bendall J, Asha SE. Incidence Emergency Nursing Journal 15:202-210. of unrecognised oesophageal intubation in patients 2013 intubated by paramedics and transported to an Australian metropolitan tertiary hospital. Paramedics Australasia Asha SE, Curtis K, Taylor C, Kwok A. Patient controlled Conference, Hobart, 2nd December 2012. analgesia compared to interval analgesic dosing for reducing complications in blunt thoracic trauma: a Ajami A (2012) The First Aid Skills Training (FAST) Project. retrospective cohort study. Emergency Medicine Journal. Multicultural health research to practice forum: St George 2013; 30: 1024-8. Hospital, NSW.

Nichols M, Acker J, Bendall J, Asha SE. Evaluating the Ajami A, Chan DT (2012) Medical Assessment and incidence of unrecognised oesophageal intubation by Decision Making in Emergency (MADMEN) Project. paramedics. Journal of Paramedic Practice. 2013; 5(4): Australasian Redesigning Healthcare Summit, Brisbane. 212-18. Curtis K, Clements A, Curtis K, Holzhauser K, Horvat L Asha SE, Chan ACF, Walter E, Kelly PJ, Morton RL, (2012) The impact of a senior nurse as nurse team leader Ajami A, Wilson RD, Honneyman D. Impact from point on communication and perceptions of leadership in major of care devices on emergency department patient trauma resuscitations. Trauma 2012 Conference: Perth. processing times compared with central laboratory Curtis K, Clements A, Holzhauser K, Horvat L (2012) testing of blood samples: a randomised controlled trial The impact of a senior nurse as nurse team leader on and cost-effectiveness analysis. Emergency Medicine communication and perceptions of leadership in major Journal. Published online first: 7 June 2013 doi:10.1136/ trauma resuscitations. 10th International Conference for emermed-2013-202632. Emergency Nursing: Hobart. Asha SE, Pryor R. Validation of a method to assess range 16 Horvat L, Fry M, Plowes J, Fong J (2012) To explore the nursing assessment and initial management of septic patients in the Emergency Department. Annual Critical Care Conference Hunter Valley, NSW.

Romero B (2012) The emergency flow Coordinator International Conference of Emergency Nursing: Hobart.

Romero B (2012) To identify delay reasons for ED patients at 4 and 8 hours allowing the early identification and escalation of delays in order to facilitate patient flow within ED. Annual Critical Care Conference Hunter Valley, NSW

Romero B, Ajami A, Bayeh G, Neuhaus L, Foreshew M, Cosgrove J (2012) To identify delay reasons for Ed patients at 4 and 8 hours allowing the early identification and escalation of delays in order to facilitate patient flow within ED. Annual Critical Care Conference: Hunter Valley, NSW.

2013 – International

Reproducibility of the seated reduction technique for anterior shoulder dislocation when performed by doctors with minimal experience in the technique. Presented as an abstract in the scientific sessions of the International Conference on Nursing & Emergency Medicine (Nursing-2013), Las Vegas, USA, December, 2013.

2013 - National

Asha SE, Pryor R. Validation of a method to assess range of motion of the cervical spine using a tape measure. Evidence review in Emergency Medicine, March 2013, Terrigal, NSW.

Chinnappa J, Arora M, Asha S, Diwan AD. Career satisfaction among Australian emergency medicine staff: a two centre cross sectional study (poster). Australasian College for Emergency Medicine ACEM annual scientific meeting, Adelaide, November 2013.

Arora M, Asha S, Diwan AD. Over half of emergency medicine staff are burned out: Results from a two-center cross-sectional study (poster) ACEM annual scientific meeting, Adelaide, November 2013.

Walter L (2013) Impact from point of care devices on emergency department patient processing times compared with central laboratory testing of blood samples: a randomised controlled trial and cost- effectiveness analysis. International Conference of Emergency Nursing: Melbourne.

17 > Emergency Department, Sutherland Hospital

Head of Department Research Projects in Progress

January 2012- November 2013 Professional Development Process Pilot Study. G.Watkins Dr David Mah, FACEM, DHA, Conjoint Lecturer UNSW. (principal investigator TSH), A. Moore, I. Ozelin. November/December 2013 Dr Enasio Morris FACEM (Locum Director). A Randomised Controlled Trial of Conservative versus Interventional Treatment of Primary Spontaneous Staff Specialists Pneumothorax. Australian New Zealand Clinical Trials Registry (ANZCTR), A. Moore (principal investigator TSH). Dr Andrea Bell, FACEM DCH Dr Murali Krishnaraj FACEM Benztropine for the relief of acute non-traumatic neck pain Dr Jeffrey Lui, FACEM randomised trial. Asha S, Kerr A, Jones K, McAlpine A Dr David Mah FACEM, DHA, Lect (conjoint) UNSW (principal investigator TSH). Dr Allison Moore FACEM Associate Prof. John Raftos, FACEM, Snr Lect (conjoint) Presentations at Scientific Meetings and UNSW Conferences Dr Katerina Tsacalos FACEM 2012 National Dr Gina Watkins BSc(Hons), DRCOG, MRCGP, FACEM, Lect (conjoint) UNSW Impact of Emergency Department Transfer Form Dr Luis Winoto FACEM Mah, D. International Conference on Emergency Medicine, Dr Peter Wyllie FACEM Dublin June.

Visiting Medical 2013 - International

Dr Javad Najafi FACEM G Watkins, Emergency Medicine Training in Australasia: Dr James Parks FACEM Nepal Emergency Medicine Seminar, Kathmandu, April.

Nursing G Watkins, Acute Nerve Injury Pain Management: 4TH International Congress on Neuropathic Pain, Toronto Ann McAlpine, Nurse Practitioner May.

2013 - National

G Watkins, Emergency Department Management of Acute Nerve Injury Pain: A review. Australasian College for Emergency Medicine (ACEM) Annual Scientific Meeting, Adelaide, November.

A Moore, Emergency Department Morbidity Audit, ACEM

Annual Scientific

18 > Department of Endocrinology

Head of Department O’Sullivan AJ, Howe A, Miles S, Harris P, Hughes CS, Jones P, Scicluna H, Leinster S. Does a summative portfolio Associate Professor Anthony O’Sullivan MBBS, FRACP, foster the development of capabilities such as reflective MD, MHPEd practice and understanding ethics? An evaluation from two Senior Medical medical schools. Medical Teacher 2012; 34: e21-e28.

Staff Specialists Imison M, Harris P, Hewson L, Jones P, McNeil PH, Moore K, O’Sullivan AJ, Velan G, Hughes C. A Bank of Stories: Associate Professor Terrance Diamond MB, BCh, MRCP, Piloting Low-Fidelity, Student-Generated Virtual Patient FRACP Cases in Undergraduate Medical Education. Focus on Dr Peter Rohl MBBS, FRACP Health Professional Education 2012; 13: 22-31. Dr Ganesh Chockalingham MBBS, FRACP, FRACGP Dr Majgorzata Brzozowska MD, FRACP Scicluna H, Grimm MC, O’Sullivan AJ, Pilotto L, Jones P, McNeil HP. Clinical capabilities of graduates of an Visiting Medical outcomes-based integrated medical program. BMC Medical Education 2012; 12: 23-30. Dr Mary Freeman MBBS, FRACP Morris J, O’Sullivan AJ. Body fat increases throughout Junior Medical pregnancy despite no significant changes in 24-hour Advanced trainees energy expenditure and caloric intake. Obesity Research Dr Bobby Chan 2013 and Clinical Practice 2012; supp 1: 59-60. Dr Aimee Hayes 2012 Golombick T, Diamond T, Manoharan A and Ramakrishna Senior Researcher R. Response to Vermorken et al – curcumin and free light chains. American J Hematology 2012;87:E80-E81. Terry Golombick PhD Dipl Nutr DOI:10.1002/ajh.23294 .

Research Grants Golombick T, Diamond T, Manoharan A and Ramakrishna R. Monoclonal Gammopathy of Undetermined St George Hospital: Multicultural Health Service Cultural Significance (MGUS), Smoldering Multiple Myeloma (SMM) Diversity Health Enhancement Grants Program. Craig and Curcumin: A Randomised, Double-blind Placebo- D, Fernandez R (2013) Clinical Management of Chinese Controlled Cross-over 4g study and an Open-label 8g speaking women with Gestational Diabetes Mellitus Extension Study. American J Hematology. 2012;87:455- speaking women with Gestational Diabetes. 2012- 2013. 460. $6,800. MM Brzozowska, A Sainsbury, J Eisman, P Baldock, J Research Projects in Progress Center. Bariatric surgery, bone loss, obesity and possible mechanisms. Obesity Reviews 2013 14(1):52-67- selected Changes in body composition and energy metabolism as “Hot topic publication” by ESA society. during pregnancy: predictive of preeclampsia and gestational diabetes mellitus? Principal investigators, A/ Olupeliyawa Asela M, Balasooriya CD, Hughes C, Prof Anthony J O’Sullivan, Odetta Davison. O’Sullivan AJ. Commencing clinical practice as a medical graduate: what collaborative behaviors and competencies Original Peer-Reviewed Publications are critical? Focus on Health Professional Education 2013; M M Brzozowska, P Davoren, “Does critical illness cause 14: 57-70. reversible Cushing’s like syndrome? A case study of Chan B, O’Sullivan AJ. Investigating disorders of two case reports and review of the literature”Journal of hyponatraemia. Endocrinology Today 2013; 2: 38-40. Diabetes and Endocrinology Vol. 3(2), pp. 22-24, March 2012. Mavros Y, Kay S, Anderberg KA, Baker MK, Wang Y, Zhao R, Meiklejohn J, Climstein M, O’Sullivan A, De Vos N, 19 Baune B, Blair SN, Simar D, Rooney K, Singh N, Fiatorone M,Wang Y, Zhao R, Climstein M, O’Sullivan AJ, Baune Singh MA. Changes in insulin resistance and HbA1c are B, Blair S, Fiatarone-Singh M. Relative muscle mass is related to exercise-mediated changes in body composition inversely associated with inflammation in older adults in older adults with Type 2 Diabetes: Interim outcomes with Type 2 diabetes. 3rd World Congress on Exercise is from the GREAT2DO trial. Diabetes Care 2013, published Medicine, San Francisco, CA 2012. No 1103. online March 8. Mavros Y, Rooney K, Kay S, Simar D, Anderberg K, Baker Tang A, O’Sullivan AJ, Diamond D, Gerard A, Campbell M,Wang Y, Zhao R, Climstein M, O’Sullivan AJ, Baune P. Psychiatric symptoms as a clinical presentation of B, Blair S, Singh N, Fiatarone-Singh M. Relative muscle Cushing’s syndrome. Annals of General Psychiatry 2013; mass is inversely associated with insulin resistance in older 12: 23. adults with Type 2 diabetes. 19th European Congress of Obesity, Lyon, France 2012. No. 851. Wong R, Golombick T, Diamond T, Manoharan A and Ramakrishna R. Curcumin enhances the cytotoxic and Morris J, O’Sullivan AJ. Body fat increases throughout chemo-sensitising effects of lenalidomide in human pregnancy despite no significant changes in 24-hour multiple myeloma cells. J Hematological Malignancies, energy expenditure and caloric intake. Australian & New 2013,Vol 3, no 2,1-7. Zealand Obesity Society Annual Scientific Meeting, Auckland, New Zealand 2012. Golombick T, Diamond T, Manoharan A and Ramakrishna R. Long term use of curcumin in two smoldering multiple Golombick T, Diamond T, Manoharan A and Ramakrishna myeloma patients. J Hematological Malignancies, 2013, R. Multiple Myeloma Precursor Disease and Curcumin. Vol 3, no 1, 18-23. 14th International Myeloma Workshop, April 3-7, 2013, Kyoto, Japan. Diamond T, Golombick T and Wong Y. The effect of oral cholecalciferol 2000 IU versus 5000 IU on serum vitamin Golombick T, Wong R, Diamond T, Manoharan A and D, PTH, bone and muscle strength in patients with vitamin Ramakrishna R. Curcumin Enhances the Cytotoxic and D deficiency. Osteoporosis International (2013)24:1101- Chemosensitising Effects of Lenalidomide in Human 1105. Multiple Myeloma Cells. Fourteenth International Myeloma Workshop, April 3-7, 2013, Kyoto, Japan. Denham JW, Nowitz, M, Joseph D, Duchesne G, Spry NA, Lamb DSs, Matthews J, Turner S, Atkinson C, Tai KH, Brzozowska, M. Bone loss following bariatric surgery: Gogna NK, Kenny L, Diamond T, Smart R, Rowan D, Comparison of different modalities, featured poster Moscato P, Woodfield R, Lynch K, Dalahunt, Murray J, presentation, The Endocrine Society 95th Annual Meeting, D’Este C, McElduff P, Steigler, A, Kautto A, and Ball J. San Francisco 2013 (awarded Postgraduate Research Impact of androgen suppression and zoledronic acid on Support Scheme (PRSS) Grant UNSW). bone mineral density and fractures in the Trans-Tasman National Radiation Oncology Group (TROG) 03.04 Randomised Androgen Deprivation and Radiotherapy (RADAR) Malgorzata Brzozowska “Bone loss following bariatric randomized controlled trial for locally advanced prostate surgery: Comparison of different modalities”-Endocrine cancer. BJU International October 15 2013 Doi: 10.111/ Society of Australia (ESA) Conference Sydney, Darling bju.12497. Harbour, April 2013 (ESA Novartis Award Finalist).

Bokhari AR, Davies MA. Diamond T. Endoscopic Jones P, O’Sullivan AJ, Velan G, Thompson R, Balasooriya transsphenoidal pituitary surgery: a single surgeon C, Kumar R, Harris P. A programmatic approach to experience and the learning curve. British J of standards-based assessment in medicine. Learning and Neurosurgery. 2013 February 27(1) 44-49. Teaching Forum: Assurance of Learning, UNSW, Sydney, Presentations at Scientific Meetings and 2012. Conferences Hayes A, Iskander A, O’Sullivan AJ, Diamond D. Will new GDM diagnostic criteria impact on resource allocation as International defined by GDM prevalence and proportion of women Brzozowska, M. Differential bone loss following gastric requiring insulin therapy? Australian Diabetes in Pregnancy surgery at 12 months-late breaking abstract with oral Society Annual Scientific Meeting, Gold Coast, 2012. presentation at the 34th Annual Meeting of the American Morris J, O’Sullivan AJ. Accumulation of body fat during Society for Bone and Mineral Research (ASBMR), pregnancy occurs despite no significant changes in energy Minneapolis, Minnesota, October 2012. expenditure and caloric intake. Australian Diabetes in Mavros Y, Rooney K, Kay S, Simar D, Anderberg K, Baker Pregnancy Society Annual Scientific Meeting, Gold Coast, 2012. 20 White C, Chen K, Lip C, Lee J, XuGuang H, Hong A, Since commencement of the Group 244 participants have Bleicher K, Lowe S, O’Sullivan A.J. Vitamin D insufficiency attended groups. The majority of referrals have been from is prevalent but does not influence glycaemia in The Diabetes Education Centre. pregnancy. Annual Scientific Meeting of the Endocrine Chinese Speaking Gestational Diabetes Mellitus Clinic Society of Australia, Gold Coast 2012. Community Engagement Introduction of a weekly block booking Chinese Interpreter supported Chinese speaking Gestational Diabetes review The Diabetes Group Report clinic. This clinic has improved access for these women and provided opportunities for regular review and The Diabetes Education Centre continues to provide a psychosocial support. service to the St George Division of General Practice for a group education program. Awards

The target group suffers from insulin resistance, impaired Dr Malgorzata Brzozowska fasting glucose, Type 2 patients. Referral sources included: NHMRC (National Health and Medical Research Council) • Diabetes Education Centre, scholarship for the PhD project, UNSW: “The association between neuropeptides, gut hormones, skeletal and • Diabetes Clinic, metabolic health”. 2009-2013 • Nutrition department,

• Other Allied Health

• General Practitioners.

Exclusions: Non English speaking and children. Venue: Division of General Practice

The program consisted: Session 1 Understanding your condition Session 2 Nutrition Session 3 Podiatry Session 4 Ophthalmology Session 5 Nutrition Session 6 Physical Activity

Each session except session 1 contain physical activity component

The session given by the educator includes the following topics:

1. Healthy eating (brief as covered by dietitian)

2. Being Active (brief as covered by exercise physiologist)

3. Monitoring

4. Taking Medication

5. Problem Solving

6. Healthy Coping

7. Reducing risks

21 > Department of Gastroenterology and Hepatology

Head of Department function analyzer, Fluoroskan Ascent FL fluorescent plate reader, Leica inverted fluorescence microscope, Grimm A/Prof Amany Zekry, MBBS, PhD, FRACP, Associate MC, O’Sullivan A, Chong B, Krilis SA, Morris DL $240,722 Professor of Medicine (2012). Senior Medical NHMRC Equipment grant + UNSW MREII scheme Prof Ian Cook, MBBS, FRACP, MD, Professor of Medicine Tuttnauer Autoclave, Step One Plus 96 well Quantitative (Conjoint) PCR Machine, AKTA Avant 150 FPLC System, Direct Detect Prof Michael Grimm, MBBS (Hons), PhD, FRACP, Clinical Spectrometer Grimm MC, Chong B, Krilis S, Morris DL, Li Associate Dean, St George and Sutherland Clinical School. Y.$353,190 , (2013). A/Prof Philip Craig, MBBch, PhD, FRACP, Associate UNSW MREII scheme, Establishment of a biostatistical Professor of Medicine (Conjoint) unit for UNSW Medicine, Hayen A, McIntyre R, Harris M, Dr John Freiman, MBBch, PhD, FRACP Lassere M, Grimm MC, Zwar N, Worth H. $387,905, (2013). Dr Lennart Choo, MBBS, FRACP Dr Gokulan Paven, MBBS, FRACP, Snr Lecturer (Conjoint) UNSW MREII scheme, Lloyd AR, Grimm MC and 15 other investigators Bioplex Magpix with wash station, $71,138 Junior Medical (2013). Dr Peter Wu, MBBS Dr Peter Lim, MBBS Research Projects in Progress Dr Vipul Aggarwal, MBBS Predicting dysphagia-related complications and improving Research Staff outcomes in patients treated with head and neck radiotherapy. Principal investigators: I Cook, M Szczesniak, Dr Michal Szczesniak, BBiomedSc (Hons), PhD, Post-Doc J Maclean, P Graham, T Omari. Research Fellow, St George and Sutherland Clinical School Ms Teng Zhang, MBiomedEng, PhD student, St George Prospective, randomized controlled trial of cricopharyngeal and Sutherland Clinical School dilatation in post-laryngectomy dysphagia. Principal Dr Greta Lee, MB BS, MMed (Clin. Epi.), FRACP, PhD investigators: P Wu, M Szczesniak, J Maclean, I Cook. student, St George and Sutherland Clinical School Ms Annie Luo, BSc (Hons), PhD student, St George and Influence of altered pharyngo-esophageal biomechanical Sutherland Clinical School parameters on swallowing and speech function in Ms Linda El-Bayeh, BSc (Hons), Research assistant, St laryngectomees, Principal investigators: T Zhang, M George and Sutherland Clinical School Szczesniak, J Maclean, P Bertrand, I Cook. Ms Lisa Dowdell Clinical Nurse Consultant – Community The role of Campylobacter concisus in the pathogenesis of Liver Disease IBD, Principal investigators: Zhang L, Grimm MC, Riordan S. Ms Amy Ko - Clinical Trials Coordinator The appendix, appendicitis, and the immunology of Research Grants protection against IBD, Principal investigators: Luo AS, Philips P, Grimm MC. NHMRC Project Grant Predicting dysphagia-related complications and improving outcomes in patients treated The role of the chemokine-chemokine receptor pair, with head and neck radiotherapy, I Cook, M Szczesniak, J CCL20-CCR6, in intestinal immunity and inflammation, Maclean, P Graham, T Omari $301,624 0; (2013 - 2015). Principal investigators: Eri R, Lyons AB, Korner H, Grimm MC. NHMRC Project Grant, Development of diagnostic tools to characterise predictors of therapeutic outcome in severe The role of balloon-assisted cholangioscopy, Principal constipationPG Dinning, I Cook, J Arkwright, M Scott, DZ investigators: Lim P, Craig P. Lubowski, $418,500; (2010 – 2012). Capsule endoscopy study of small bowel Crohn’s disease UNSW MREII scheme Veneflux system, Multiple platelet patients in clinical remission, Principal investigators: 22 Aggarwal V, Day AS, Connor SJ, Leach ST, Brown, GJ. interferon-α and ribavirin in Treatment-naïve patients with Singh R, Friedman A, Grimm MC, Craig, PI. Chronic Genotype 1b HCV Infection. Principal investigator: A/Prof Amany Zekry. Gilead 121. Phase 2 Randomized, Open-Label, Exploratory Trial of GS 5885, GS 9451 with Peginterferon Alfa 2a A Multi centred 3 year follow up study to assess the (PEG) and Ribavirin (RBV) in Treatment-Naïve subjects with durability of sustained virologic response to Alisporivir chronic Genotype 1 Hepatitis C virus Infection and IL28B treated chronic HCV patients. Principal investigator: A/Prof CC Genotype Principal investigator: A/Prof. Amany Zekry. Amany Zekry.

Gilead – FISSION. Phase 3, Multicenter, Randomized, A Multicenter, Randomized, Double-blind, Phase 3 Study Active-controlled Study to investigate the safety and of Ramucirumab (IMC-1121B) Drug Product and Best efficacy of PSI-7977 and Ribavirin for 12 weeks Compared Supportive Care (BSC) versus Placebo and BSC as Second- to Pegylated Interferon and Ribavirin for 24 weeks in line Treatment in Patients With Hepatocellular Carcinoma treatment-naïve patients with chronic genotype 2 or 3 HCV F ollowing First-line Therapy. Principal investigator: A/Prof infection, Principal investigator: A/Prof Amany Zekry. Amany Zekry.

Gilead 109. Open label study of GS7977 and Ribavirin Original Peer-Reviewed Publications for 12 weeks for subjects with chronic HCV infection who participated in prior studies evaluating GS7977, Principal 2012 investigator: A/Prof Amany Zekry. Dinning PG, Hunt L, Arkwright JW, Patton V, Szczesniak Phase 3, Open Label study with Asunaprevir and MM, Wiklendt L, Davidson JB, Lubowski DZ, Cook IJ. Daclastasvir (DUAL) for Null/partial responders to Peg Pancolonic motor response to sub-and suprasensory sacral Alfa 2a and Ribavirin, Intollerant/Ineligible naïve to P/R nerve stimulation in patients with slow transit constipation. subjects, and treatment naïve subjects with chronic HCV Br J Surg. 2012; 99(7):1002-10. genotype 1b, Principal investigator: A/Prof Amany Zekry. P.I. Craig, The role of endoscopic stenting for biliary BMS-A1444-026. An open-label re-treatment study with strictures in chronic pancreatitis. Dig Endosc. 2012; Peg-Interferon Alfa-2, Ribavirin and BMS-7090052 with or 24(Suppl 1):38-42. without BMS-650032 for subjects with Chronic Hepatitis C, McNeil HP, Scicluna H, Boyle P, Grimm MC, Gibson KA, Principal investigator: A/Prof Amany Zekry. Jones P. Successful development of generic capabilities Novartis DEB025A2210. A phase II clinical trial to evaluate in an undergraduate medical education program. Higher the efficacy and safety. A multicentre, randomized, double- Education Research and Development 2012; 31:525-539. blind, placebo-controlled, parallel-group phase II study on Ismail Y, Mahendran V, Octavia S, Day AS, Riordan the efficacy and safety of DEB025/Alisporivir combined SM, Grimm MC, Lan R, Lemberg D, Tran TAT, Zhang L. with peg-IFN alfa-2a and ribavirin in chronic hepatitis C Investigation of the enteric pathogenic potential of oral genotype 1 patients who are previous peg-IFN alfa-2 plus Campylobacter concisus strains isolated from patients with ribavirin treatment-non-responders, Principal investigator: inflammatory bowel disease.PLoS ONE 2012; 7(5):e38217. A/Prof Amany Zekry. Scicluna H, Grimm MC, O’Sullivan AJ, Pilotto L, Jones Novartis DEB025A2301. A randomized, double-blind, P, McNeil HP, Clinical capabilities of graduates of an placebo-controlled trial of the efficacy and safety of outcomes-based integrated medical program. BMC DEB025/Alisporivir in combination with standard of care in Medical Education 2012; 12:23-28. hepatitis C genotype 1 treatment naïve patients. Principal investigator: A/Prof Amany Zekry. Choo L, Conway J, Mishra G. The role of endoscopic ultrasound in biliary obstruction. Current Gastroenterology A Phase III, Randomised, open label, parallel group, Reports 2012; 14(6): 520-7. Active-controlled study of an interferon-free regimen of BI 207127 in combination with Faldaprevir and Ribavirin Keoshkerian E, Helbig K, Beard M, Zaunders J, Seddiki N, compared to Telaprevir in combination with pegylated 23 Kelleher A, Hampartzoumian T, Zekry A, Lloyd AR. A novel Mahendran V, TanYS, Riordan SM, Grimm MC, Day AS, assay for detection of hepatitis c virus-specific effector Lemberg DA, Octavia S, Lan R, Zhang L. The prevalence cd4(+) t cells via co-expression of cd25 and cd134. Journal and polymorphisms of zonula occluden toxin gene in of immunological Methods 2012;375:148-158. multiple Campylobacter concisus strains isolated from saliva of patients with inflammatory bowel disease and Guirgis M, Yan K, Bu YM, Zekry A. General practitioners’ controls. PLoS ONE 2013; 8(9):e75525. knowledge and management of viral hepatitis in the migrant population. Internal Medicine Journal 2012; Zbaras B, Sam LN, Grimm MC. Thrombotic 42:497-504. thrombocytopaenic purpura associated with adalimumab (Humira) treatment in Crohn disease. Internal Medicine Guirgis M, Nusair F, Bu YM, Yan K, Zekry AT. Barriers faced Journal 2013; 43(2): 216-217. by migrants in accessing healthcare for viral hepatitis infection. Internal Medicine Journal 2012; 42:491-496. Other Published Material

2013 Cook IJ. Investigating the patient with difficulty swallowing: The importance of a thorough history. Szczesniak MM, Fuentealba SE, and Cook IJ. Acid Medicine Today 2012;13(9):48-53. Sensitization of Esophageal Mucosal Afferents: Implication for Symptom Perception in Patients across the Cook IJ. Zenker’s Diverticulum. In: Shaker R, Postma G, Gastroesophageal Reflux Disease Spectrum. Clin J Pain Belafsky P, Easterling C, Eds Principles of Deglutition: A 2013; 29(1):70-7. Multidisciplinary Text for Swallowing and its Disorders. New York: Springer: 2013. (ISBN 978-1-4614-3794-9). Elliott TR, Wu PI, Fuentealba S, Szczesniak M, de Carle DJ, Cook IJ. Long-term outcome following pneumatic Cook IJ. Globus Pharyngeus In: Shaker R, Postma G, dilatation as initial therapy for idiopathic achalasia: an Belafsky P, Easterling C, Eds Principles of Deglutition: A 18-year single-centre experience. Aliment Pharmacol Ther. Multidisciplinary Text for Swallowing and its Disorders. 2013; 37(12):1210-9. New York: Springer: 2013. (ISBN 978-1-4614-3794-9). Kumbhari V, Behary J, Szczesniak M, Zhang T, Cook IJ. Presentations at Scientific Meetings and Efficacy and safety of pneumatic dilatation for achalasia in Conferences the treatment of post-myotomy symptom relapse. Am J Gastroenterol. 2013; 108(7):1076-81. 2012 - International

Szczesniak MM, Fuentealba SE, Zhang T, Cook IJ., I.J. Cook, Newer understanding of UES function Modulation of esophageal afferent pathways by 5-HT3 with high resolution manometry. Joint International receptor inhibition. Neurogastroenterol Motil. 2013; Neurogastroenterology and Motility Conference, Bologna, 25(5):383-8, e293. Italy, Sept 2012.

Ismail Y, Lee H, Riordan SM, Grimm MC, Zhang, The V. Kumbhari, J. Behary, M.M. Szczesniak, M. Naidoo, effects of oral and enteric Campylobacter concisus strains I.J. Cook, Efficacy and Safety of Pneumatic Dilatation on expression of TLR4, MD-2, TLR-2, TLR5 and COX-2 in in Patients With Achalasia Who Relapse Post Heller HT-29 cells. PLoS ONE 2013; 8(2):e56888. Myotomy. Gastroenterology, Volume 142, Issue 5, Supplement 1, May 2012, Page S-282. Walsh AJ, Weltman M, Burger D, Vivekanandarajah S, Connor S, Howlett M, Radford-Smith G, Selby W, Veillard S. Paramsothy, J. Maclean, M. M. Szczesniak, I. J. Cook. AS, Grimm MC, Travis SPL, Lawrance I. Implementing Cricopharyngeal Dilatation for Post Laryngectomy guidelines on the prevention of opportunistic infections Dysphagia - a Pilot Study of Efficacy and Safety. in inflammatory bowel disease. Journal of Crohn’s and Gastroenterology, Volume 142, Issue 5, Supplement 1, Colitis. 2013; 7:e449–e456. May 2012, Page S-235.

Handford C, Burton A, Lemon J, Grimm MC, Vollmer- S. Paramsothy, J. Maclean, M. M. Szczesniak, I. J. Cook. Conna U. Reading emotion in the eyes: empathy as a Oesophageal Dysmotility in Laryngectomy Patients - is function of clinical exposure. PLoS ONE 2013; 8(6):e65159. There an Association? Gastroenterology, Volume 142, Issue 5, Supplement 1, May 2012, Pages S-235-S-236. Lee AYS, Eri R, Lyons AB, Grimm MC, Korner H. CC chemokine ligand 20 and its cognate receptor CCR6 P.I. Craig, Contrast capsule endoscopy: The Australian in mucosal T cell immunology and inflammatory bowel experience. Capsule Endoscopy Experts Forum CEEF, disease: Odd couple or axis of evil? Frontiers in Mucosal Vienna, February. Immunity 2013; 4:194-200. V. Aggarwal, A.S. Day, S.J. Connor, S.T. Leach, G.J.

24 Brown, R. Singh, A, Friedman, M.C. Grimm, P.I. Craig, PI Craig. Luminal stenting: Do’s and Don’ts. Australian “Multicenter capsule endoscopy study of small bowel Gastroenterology Week, Adelaide, October. Crohn’s disease patients in clinical remission: long-term PI Craig. Capsule endoscopy in Crohn’s: Assessing disease follow-up and correlation with faecal biomarkers and remission. Australian Gastroenterology Week, Adelaide, clinical outcome.”, Oral, DDW Gastroenterology 142 (5). October. Grimm M.C. The appendix in IBD: from epidemiology to Grimm M.C. Inflammatory cascades in IBD, Macarthur mechanism. Oral, Oxford IBD Masterclass, Oxford, UK. Series in Immunology. Campbelltown, NSW. 2012 - National Grimm M.C. Pregnancy and IBD. Society of Obstetric Szczesniak M, Fuentealba SE, Cook IJ. Involvement of Medicine of Australian and New Zealand Annual Scientific 5-HT3 neural pathways in oesophageal sensitivity and Meeting Sydney, NSW. acid-induced viscerosomatic sensitisation. Oral, Australian Choo L, Mishra G, Conway J, Evans J. Prospective single Gastroenterology Week, Adelaide, October. Journal of blinded study of EUS prior to ERCP for patients with a Gastroenterol Hepatol 2012:27(Suppl 4):A155 . positive intra-operative cholangiogram. Oral, Australian Lim P, Craig PI. Balloon-assissted cholangioscopy: Gastroenterology Week. Adelaide, October. technique, diagnostic and therapeutic applications. Oral Choo L, Mishra G, Evans J, Conway J. Endoscopic (video forum), Australian Gastroenterology Week, ultrasound training: The impact on procedure time and Adelaide, October. complications. Poster, Australian Gastroenterology Week. Ghaly S, Craig PI. Over the scope clip to close an Adelaide, October. entero-cutaneous fistula. Oral (video forum), Australian Wu PI, Szczesniak MM, Craig PI, Choo L. Predictors Gastroenterology Week, Adelaide, October. of rebleeding in high risk peptic ulcer disease in the Lim P, Aggarwal V, Craig PI., Peroral balloon-assisted era of modern endoscopic therapy and high dose cholangioscopy for complex biliary disease in a multi- intravenous proton pump inhibitors. Poster, Australian ethnic cohort. Oral, Australian Gastroenterology Week, Gastroenterology Week. Adelaide, October. Adelaide, October. J Gastroentrol & Heptol, 27 (supp Choo L. AGEA update 2013- pancreatico-biliary. 4):S59. Australian Gastroenterology Week, Adelaide, Aggarwal V, Day AS, Connor SJ, Leach ST, Brown GJ, October. Singh R, Friedman A, Grimm MC, Craig, PI. Multicenter 2013 - International capsule endoscopy study of small bowel Crohn’s disease patients in clinical remission: long-term follow-up and M.M. Szczesniak, J. Maclean, T. Zhang, P. Graham, correlation with faecal biomarkers and clinical outcome. IJ. Cook. Prevalalence of Dysphagia as a long term Oral, Australian Gastroenterology Week, Adelaide, complication of head and neck radiotherapy, Oral October, J Gastroentrol & Heptol, 27 (supp 4):S96. Presenation 3rd Congress of the European Society for Swallowing Disorders, 2013 Malmo, Sweden. PI Craig. Inflammatory lesions , NETI National Endoscopy Training Initiative, capsule course, Sydney; July. M.M. Szczesniak, T.I. Omari, J. Maclean, R. Liu, T. Zhang, I.J. Cook. Inter-rater reliability of automated impedance- PI Craig. Tumours and polyposis syndrome, NETI National manometry (AIM) analysis and fluoroscopy in patients with Endoscopy Training Initiative, capsule course, Sydney; July. dysphagia following head and neck radiotherapy. Oral PI Craig. Primary sclerosing cholangitis: Endoscopic Presenation 3rd Congress of the European Society for management and cholangiocarcinoma diagnosis. ALA Swallowing Disorders, 2013, Malmo, Sweden. Australian Liver Association Masterclass, Sydney, July. M.M. Szczesniak, Cook I.J. Normal values for sydney PI Craig. New paradigms in pancreatico-biliary diseases: swallow questionnaire (SSQ), Poster Presentation, case-based discussion and updates. Gut Club, Sydney; 3rd Congress of the European Society for Swallowing August. Disorders, Malmo, Sweden, 2013.

PI Craig. Australian Multicentre Balloon-assisted Rebecca Burgell, Michal M. Szczesniak, Priyanka Cholangioscopy Study. Oral, ANZELF Australia & New Yerragorla, Emma V. Carrington, Sahar Mohammed, Zealand Endoscopy Leaders Forum: Darwin; August. Peter J. Lunniss, Philip G. Dinning, S. Mark Scott. Quality, Intensity and Location of the Urge to Defaecate Differs PI Craig. Entero-cutaneous fistula closure with an OTSC Between Patients With Constipation and Healthy Subjects, device. ANZELF Australia & New Zealand Endoscopy DDW, Gastroenterology, Volume 144, Issue 5, Supplement Leaders Forum: Darwin; August. 25 1, May 2013, Page S-935.

Lim P, Craig PI. The role of balloon-assisted cholangioscopy: Diagnosis and Therapy, Oral (video forum) Digestive Diseases Week, Orlando, FA. USA, May.

Lim P, Aggarwal V, Craig PI, The role of balloon-assisted cholangioscopy in a multi-ethnic cohort to assess complex biliary disease. Digestive Diseases Week, Orlando, FA. USA, May.

National - 2013

PI Craig. Advances in the endoscopic diagnosis of malignancies of the bile duct. Oral, Australian Gastroenterology Week, October, Melbourne.

PI Craig. Intrahepatic biliary dysplasia complicating a choledochal cyst: Diagnosis and management. Australian Gastroenterology Week, October, Melbourne.

PI Craig. Defining normal and normal variants in capsule endoscopy. NETI National Endoscopy Training Initiative, capsule course, Sydney.

PI Craig. Direct Cholangioscopy in 2013 and Beyond. RPAH Biliary Workshop, Sydney.

Wu PI, Szczesniak MM, Craig PI, Choo LK. Predictors of rebleeding in high risk peptic ulcer disease in the era of modern endoscopic therapy and high dose intravenous proton pump inhibitors. Australian Gastroenterology Week, October, Melbourne.

Grimm M.C. Optimising therapy in IBD. Raising Expectations in Gastroenterology, Sydney and Newcastle.

Luo AS, Jung H-J, Philips P., Grimm M.C. The mechanisms of regulatory T cell expansion following appendicitis induction. Poster, Australian Gastroenterology Week, October, Melbourne.

26 > Infectious Disease, Immunology and Sexual Health

Head of Department St. George & Sutherland Medical Research Foundation, Innate Immunity in Thrombosis and Ischaemia Perfusion Prof. Steven A. Krilis, MB BS PhD DSc (Hons) FRACP Injury Principal investigators Steven Krilis, $30,000, 2013. FAAAA, Conjoint Professor of Medicine UNSW NSW Ministry of Health, NSW Rapid HIV Testing Senior Medical Evaluation Framework, Principal Investigators: Rebecca Dr. Pamela Konecny, MB BS MD DTM&H(Lon) FRACP Guy, Garrett Prestage Damian Conway, Martin Holt, FAChSHM Conjoint Snr Lecturer in Medicine UNSW Andrew Grulich, John Kaldor, Philip Cunningham, Dr. Chris Weatherall, MB BS PhD FRACP, Conjoint Lecturer $433,210 over 2 years (2013-2014). in Medicine UNSW Australian Rotary Health & The Kirby Institute HIV PhD Dr. Josephine Lusk, BSc MBChB FRNZCGP DRCOG Scholarship, Novel approaches to HIV testing for men who FAChSHM MPH Dip MGT, Conjoint Senior Lecturer have sex with men, Investigator: Damian Conway, $72,000 Medicine, UNSW, Director of Sexual Health over 2.5 years (January 2012-July 2014). Dr. Damian Conway, MB BCh, MMed (HIV/STD) FAChSHM MRCGP, Lecturer in Medicine UNSW Research Projects in Progress Dr. Catherine Pell, MBBS MM (Sex Hth) FAChSHM Delineation of the role of RasGRP4 in mast cell growth, Research differentiation, Principal investigator: Steven Krilis.

Sharon Robinson CNC Clinical Trials Tests for risk of thrombosis in patients with certain Dr. Bill Giannakopoulos MBBS PhD FRACP – Director of autoimmune conditions , Principal investigators Bill Research Giannakopoulos, Steven Krilis. Dr. Jian Chen Qi Master of Medicine , PhD, Senior Scientist./Laboratory Manager NSW Rapid HIV Testing Evaluation Framework, Principal Miao Qi, Bachelor of Medicine in Medical Laboratory Investigators: Rebecca Guy, Garrett Prestage Damian Science, MSc (UNSW). Conway, Martin Holt, Andrew Grulich, John Kaldor, Philip Peyman Mirarabshahi, PhD Cunningham. Mahmood Abdelatti MSc Original Peer-Reviewed Publications Visiting Fellow Dr. Peng Zhang, Bachelor of Clinical Medicine, PhD 2012 Visiting Fellow Dr. Siajun Zhou, Bachelor of Clinical Medicine, MSC, PhD Adachi R, Krilis SA, Nigrovic PA, Hamilton MJ, Chung Postdoctoral Fellow Dr. Gang Chen, MBBS, PhD K, Thakurdas SM, Boyce JA, Anderson P, Stevens RL. Ras guanine nucleotide releasing protein-4 (RasGRP4) Research Grants involvement in experimental arthritis and colitis. J Biol Chem. 2012 Jun 8;287(24):20047-55. NHMRC, Tests for risk of thrombosis in patients with certain autoimmune conditions. Principal investigators Giannakopoulos B, Gao L, Qi M, Wong JW, Yu DM, Steven Krilis, Bill Giannakopoulos, $300,000, $190,000, Vlachoyiannopoulos PG, Moutsopoulos HM, Atsumi T, $190,000, 2012-2014. Koike T, Hogg P, Qi JC, Krilis SA. Factor XI is a substrate for oxidoreductases: Enhanced activation of reduced FXI NHMRC, Delineation of the role of RasGRP4 in mast cell and its role in antiphospholipid syndrome thrombosis. J growth, differentiation and activation, using RasGRP4 Autoimmun. 2012 Sep;39(3):121-9. deficient mice. Principal investigator Steven Krilis $204,500 yearly, 2010-2012. Giannakopoulos B, Mirarabshahi P, Krilis S. New insights into the biology and pathobiology of Beta 2-glycoprotein UNSW Goldstar Award, The role of Mast cell specific I. Curr Rheumatol Rep. 2012;13:90-5. proteases in inflammatory bowel disease in mice and humans. Principal investigators Steven Krilis, Michael Mirarabshahi P, Abdelatti M, Krilis S. Post-translational Grimm $40,000, 2012. oxidative modification of B2-glycoprotein I and its role in 27 the pathophysiology of the antiphospholipid syndrome. Bavinton BR, Brown G, Hurley M, Bradley J, Keen P, Autoimmun Rev. 2012;11(11):779-80. Conway DP, Guy R, Grulich AE, Prestage G. Which gay men would increase their frequency of HIV testing with Erkan D, Lockshin MD; APS ACTION members. (Krillis S) home self-testing? AIDS and Behavior. 2013:1-9. APS ACTION--AntiPhospholipid Syndrome Alliance for Clinical Trials and International Networking. Lupus. 2012 Other Published Material Jun;21(7):695-8. 2012 Conway DP, Healey LM, Rauwendaal E, Templeton DJ, Davies SC. Providing HIV negative results to low-risk Conway D, Holt M, Atkinson M, Marshall L, McCloskey clients by telephone. Sexual Health. 2012, 9(2): 160-165. J, Langdon P, Callander D, Guy R. The Western Australia Sexual Health Service (WASHS) Project: A review of sexual 2013 health services for gay, bisexual and other men who have sex with men in Western Australia. Survey report July Giannakopoulos B, Krilis SA. The pathogenesis of the 2013. The Kirby Institute, Sydney. antiphospholipid syndrome. N Engl J Med. 2013 Mar 14;368(11):1033-44. Presentations at Scientific Meetings and Yong A, Pennings G, Wong C, Javadzadegan A, Brieger Conferences D, Lowe H, Qi M, Behnia M, Krilis S, Kritharides L. 2012 - International Intracoronary upregulation of platelet extracellular matrix metalloproteinase inducer (CD147) in coronary disease. Int Krillis S. Invited speaker. The role of oxidation in induction J Cardiol. 2013 Jul 1;166(3):716-21. of autoantibodies to Beta 2GPI in patients with the Antiphospholipid syndrome. Autoimmunity Workshop. Lusk MJ, Uddin RNN, Lahra MM, Garden FL, Kundu Athens, Greece. July. RL, Konecny P. Pharyngeal Gonorrhoea in Women: An Important Reservoir for Increasing Neisseria gonorrhoea Krillis S. Invited speaker. Management of thrombosis Prevalence in Urban Australian Heterosexuals?,” Journal in the Antiphospholipid syndrome. Excellence in of Sexually Transmitted Diseases 2013: Article ID 967471 Rheumatology. Madrid, Spain. 25-January. 5 pages. Krillis S, Chairperson. Antiphospholipid syndrome. Wierema J, Konecny P, Links M. Implementation of risk Madrid, Spain. January. stratified antibiotic therapy for neutropenic fever: what Krillis S. Invited participant. FXI is a substrate for are the risks? Internal Medicine Journal 2013:43(10): oxidoreductases: enhanced activation of reduced FXI 1116–1124. and its role in Antiphospholipid syndrome thrombosis. Bourne C, Allen D, Brown K, Davies SC, McNulty A, Haemostasis. Smith DE, O’Connor CC, Couldwell D, Jackson E, Bolton Gordon Research Conference. Water Valley, New M, Rodgers C, Konecny P, Smith DJ, Parker A. What Hampshire, USA. July. proportion of sexually transmissible infections and HIV are diagnosed in New South Wales’ public sexual health Krillis S. Recent developments in the pathogenesis of services compared with other services? Sexual Health Antiphospholipid syndrome. Autoimmunity symposium 2013; 10(3):290. University of Athens, Athens, Greece, September.

Prabhu A, Taylor P, Konecny P, Brown M. Pyelonephritis: Krillis S. Invited speaker. The role of oxidative What are the present day causative organisms and modification of Beta 2GPI induction of autoantibodies antibiotic susceptibilities? Nephrology 2013;18:463–467. in the Antiphospholipid syndrome. Department of Rheumatology, Clinical Immunology Series, Beth Israel Xu Y, Weatherall C, Bailey M, Alcantara S, De Rose R, Hospital, Harvard Medical School, USA, October. Estaquier J, Wilson K, Suuzuki K, Corbeil J, Coo[per DA, Kent SJ, Kelleher AD, Zaunders J. Simian 2012 - National immunodeficiency virus infects follicular helper CD4+ Tcell T cells in lymphoid tissues during pathogenic infection of Krillis S. Invited speaker. The role of mast cells in innate pigtail macaques. J Virol 2013 Apr; 87(7):3760-73. immunity. 3rd Australasian Wound and tissue Repair Society and 9th Australasian Society for Dermatology Lusk MJ, Uddin RNN, Lahra MM, Garden FL, Kundu RL Research. National conference. Sydney, May. and Konecny P. Pharyngeal Gonorrhoea in Women: An Important Reservoir for Increasing Neisseria gonorrhoea Krillis S. Session Chair – Autoimmunity and Allergy. 3rd Prevalence in Urban Australian Heterosexuals? Journal of Australasian Wound and Tissue Repair Society and 9th Sexually Transmitted Diseases. Volume 2013;1-5. Australian Society for Dermatology Research, May. 28 Conway DP, Guy R, Davies SC, Couldwell DL, McNulty Sept 10-13. A, Smith DE, Cunningham P, Keen P, Holt M. Rapid Holt M, McNulty A, Couldwell DL, Smith DE, HIV testing is acceptable and preferred among gay Conway DP, Davies SC, Cunningham P, Keen P, Guy R on behalf of the men attending sexual health clinics: findings from the Sydney Rapid HIV Test study. Field performance of the Sydney rapid testing study (Oral). Australasian HIV/AIDS Alere Determine HIV Combo assay in a large Australian Conference, Melbourne 17-19 October. multi-centre study in a sexual health clinic setting. STI & Conway DP, Holt M, McNulty A, Couldwell DL, Smith DE, AIDS World Congress 2013, Vienna July 14-17. Davies SC, Cunningham P, Keen P, Guy R. Operational , Guy R, McNulty A, Couldwell DL, Davies SC, performance of the Determine HIV Combo rapid test Conway DP Smith DE, Keen P, Cunningham P, Holt M. Experience of when used to test gay and bisexual men for HIV in rapid HIV testing increases its acceptability to clinical staff Sydney sexual health clinics (Oral). Australasian HIV/AIDS in public sexual health clinics in Sydney (Poster). STI & Conference, Melbourne 17-19 October. AIDS World Congress 2013, Vienna July 14-17. Bavinton B, Conway D, Keen P, Guy R, Prestage G. Which 2013 - National gay men would use home HIV testing (Oral)? Australasian HIV/AIDS Conference, Melbourne 17-19 October. Conway DP. Rapid HIV Testing in Australia (Oral - invited speaker). Australasian HIV/AIDS Conference, Darwin 21-23 Causer LM, Kuramop M, Karapanagiotidis T, Ryan C, October. Wand H, Conway D, Denham I, Anderson D, Robertson P, Leslie D, Donovan B, Fairley C, Kaldor J, Guy R. Conway DP, Holt M, McNulty A, Couldwell DL, Smith Laboratory evaluation of five point-of-care tests for the DE, Davies SC, Cunningham P, Keen P, Guy R. Field diagnosis of syphilis (Oral). 13th International Union performance of the Alere Determine HIV Combo assay against Sexually Transmitted Infections (IUSTI) World in recent HIV infection and overall in the Sydney Rapid Congress, Melbourne 15-17 October 2012. HIV Test Study (Oral). Australasian HIV/AIDS Conference, Darwin 21-23 October 2013. 2013 - International , Guy R, McNulty A, Couldwell DL, Davies SC, Krillis S. Invited Speaker . Posttranslational forms of B2GPI Conway DP Smith DE, Keen P, Cunningham P, Holt M. Effect of testing in diabetic complications. 2013 International Diabetes experience and profession on staff acceptability of rapid Summit Forum, Tianjin, China. HIV testing in public sexual health clinics in Sydney (Oral). Krillis S. Invited speaker and member of organising Australasian HIV/AIDS Conference, Darwin 21-23 October committee 1. Post-translational modification of B2GPI 2013. in the antiphospholipid syndrome: implications for , Guy R, Atkinson M, Marshall L, McCloskey autoantibody formation, 2. Chairman; treatment of Conway DP J, Langdon P, Callander D, Jamil MS, Holt M. Clients at thrombosis in the antiphospholipid syndrome. XIV M Clinic, a novel community/peer-worker based clinical International Congress on Antiphospholipid Antibodies, service targeting gay and bisexual men, prefer non- Rio De Janeiro, Brazil, October. traditional methods for HIV/STI testing and result delivery Krillis S. Invited speaker. The role of oxidation of (Poster). Australasian Sexual Health Conference, Darwin complement control proteins in human inflammation. 23-25 October 2013. Brigham and Women’s Hospital, Harvard Medical School , Leeman C, Cornwall J, Conway D, Guy Seminar Programme, Boston, USA, July. Cunningham PH R, Kelleher AD. Sensitivity evaluation of six rapid tests for Krillis S. Invited speaker. The role of oxidative post- detection of Human Immunodeficiency Virus Infection translational modification of B2GPI in patients with (Oral). Australasian HIV/AIDS Conference, Darwin 21-23 the antiphospholipid syndrome. Seminar Programme October 2013. Rockefeller University, July. Couldwell D, Biggs K, Townsend J, Conway D, Keen P, Krillis S. Invited speaker. Diagnostic tests in the Holt M, Guy R. Reasons why men decline rapid HIV testing antiphospholipid syndrome: post-translational forms of (Poster). Australasian HIV/AIDS Conference, Darwin 21-23 B2GPI using novel ELISAs. Instrumentation Laboratories October 2013.t the Werfen Group. Boston, USA, May. Robinson S. and Weatherall, C. Poster Presentation, Konecny P,. Adhikari SA, Choo L K V, Patil M, Duflou J, “Eviplera: a case or two for switching” abstract presented McWhinney B, Pretorius C, Weatherall C.J. Parenteral at 2013 Australasian HIV conference, Darwin. Ivermectin Pharmacology in Strongyloidiasis: Post- mortem Analysis (Oral). 53rd Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Denver, 29 Awards

NSW Health Awards

2013 Annual NSW Health Innovation Award for Integrated Health Care: “Bug Attack - St George Hospital Fight Back: Confronting Resistance” Antimicrobial Stewardship Team 2008-2012, Department Infectious Diseases, Immunology & Sexual Health.

2013 NSW Minister’s Award for Doctors-in-Training Winner: Advanced Trainee Infectious Diseases, Dr Catherine Berry , Department Infectious Diseases, Immunology & Sexual Health.

30 > Department of Intensive Care, St George Hospital

Head of Department Dr Barbara Trytko, BMBS, FANZCA, FFICANZA, FCICM Dr Monique Leijten, MD, EDIC FCICM A/Prof Theresa Jacques MBBS (Hons) FANZCA FCICM Dr Marek Nalos, MBBS, PhD, EDIC, FCICM MHL, Director, Department of Intensive Care, Conjoint Dr Mathew Macpartlin, MBBS, MRCPI, FACEM, FCICM Associate Professor University of New South Wales, Dr Nhi Nguyen MBBS, B Med Sc, FCICM Donation Specialist -Medical DONATE LIFE NSW Dr Paris Jain MBBS, MD, EDIC, FCICM Senior Medical Dr Razavian Maziar, MBBS, FCICM

Dr Kush Deshpande MBBS, MD, FCICM, Deputy Director, Junior Medical Officers - Senior Registrars Department of Intensive Care Unit, Senior Staff Specialist , Dr Kiran Deol MBBS Conjoint Lecturer, St George Clinical School, UNSW Dr.Mahadev Patil Professor John Myburgh MBBCh PhD FANZCA FCICM Dr Menaka Perumbuli Achchige MBBS, MD Anaesthesia FAICD (Head of Research (Program), Professor of Critical Dr Rosalba Cross Care Medicine, University of New South Wales, Director, Dr Raju Pusapati Division of Critical Care & Trauma, George Institute for Dr Swapnil Pawar MBBS, MD Global Health, Honorary Professor, University of Sydney, Dr Syed Ali MBBS,MD Honorary Adjunct Professor, Monash University Dr.Tejo Kapalli MBBS, MD, FCICM

A/Professor George Skowronski MMBS (Hons), Research Staff FRCP,FRACP, FCICM, Conjoint Associate Professor, Critical Saxena MK PhD Candidate Care, UNSW Hammond N PhD Candidate A/ Prof Konstantin Yastrebrov MBBS (Hons) PhD FCICM Nair P PhD Candidate FACRRM DDU , Conjoint Associate Professor University Willenberg L MPhil Research of NSW, Senior Honorary Fellow, The University of Liu A MBBS BSc (Medicine) Melbourne. Bass F MPhil Candidate Liang S MBBS Candidate Dr Doris Lam FCICM, FANZCA, MBChB, Conjoint Lecturer, Miller J Graduate Certificate in in Clinical Research St George Clinical School, UNSW Research Assistants Dr Manoj Saxena MRCP, FRACP, F.J.F.I.C.M, F.C.I.C.M, M.B. B. Chir, Bsc (Hons) Deborah Inskip, BSc, Grad Cert Crit Care, CNS, Quality, (Deputy to Head of Research Program), Conjoint Lecturer, Education, Research and Information Officer, Research St George Clinical School, UNSW Coordinator Jennene Miller, BSc, Grad Cert Crit Care, Grad Cert Clin Dr Andrew Cheng BHB, MBChB (NZ), FCICM, Hospital Research, CNS, Research Coordinator Medical Director – Organ and Tissue, Conjoint Lecturer, St Rebecca Sidoli, Dip Apl Sc, ICU Cert, CNS, Quality, George Clinical School, UNSW, Director Organ and Tissue Education, Research and Information Officer 2012, Donation Specialist -Medical DONATE LIFE NSW Amy Liu, B.Sc. (1st Class Honours), University of NSW Medical Student 2012 Dr Carton Costello MB BCH BAO, FCICM, FACRRM, Sophie Liang, University of Sydney Medical Student 2013 FRACGP, BA Com, Grad Dip Crit Care Echo, Donation Specialist – Nursing & Allied Health Medical DONATE LIFE NSW , Director Organ and Tissue 2013, Conjoint Appointee, USNW Sarah Jones RN, Grad Cert ICU, Grad Dip Education, CNC Suman Adhikari, Bpharm, Grad Dip Clin Pharm ICU Visiting Medical Officers Pharmacist Wendy Chaseling B.App.Sc. (physio), M.Ed. M.Hth.Sc Dr Asako Ito B Med, FCICM (physio) M.A.P.A. APA Cardiorespiratory Physiotherapist, Dr Atul Gaur MBBS, MD, FRCA, FCICM Senior ICU Physiotherapist 31 Theodora Bikou BSW Senior Social Worker ICU Intensive Care Foundation, Vitamin D dosing study in Dallas Nolan BSW Social Worker ICU2 intensive care unit patients with the systemic inflammatory Warren Eather, Clinical Data Manager response syndrome, Principal Investigators: Nair P, Kylie Fraser. BappSc OT, Manager St George Clinical Skills Venkatesh B, Center J, Myburgh J.A, Krishnan A. $29 000; Centre. 2013-2014.

Research Grants Nursing & Midwifery Strategy Funding, Study of Communication Practices I ICU, Principal Investigators: S NHMRC, A randomised controlled trial of prophylactic Jones, J Bothe, $9000. hypothermia in severe traumatic brain injury (POLAR trial) (Project Grant: 545901) Principal Investigators: Cooper Fresenius Kabi to University of Sydney / The George D.J. Bernard S, Nichol A., Presneill J, Cameron P, Myburgh Institute for Global Health, The Crystalloid vs Hydroxyethyl JA, $1.95M; 2009-2013. starch Trial. (CHEST), Principal Investigators: Myburgh J.A., MacMahon S. $7.6M; 2008-2012. NHMRC, The Crystalloid vs Hydroxyethyl starch Trial. (CHEST) (Project Grant: 632503) Principal Investigators: Health Research Council of New Zealand, A placebo- Myburgh J.A. Finfer S.R, Bellomo R, Lipman J, Webb S.R, controlled trial of paracetamol in febrile patients with Liu B. $2.1M; 2010-2014. severe sepsis. (HEAT study). Principal Investigators: Beasley R, Young P, McGuinness S, Freebairn R, Van Haren NHMRC, National Centre for Intensive Care research F, Henderson S, McArthur C, Bellomo R, Myburgh J.A, (Enabling grant extension: 606978) Principal Investigators: Saxena M, Webb S, Weatherall M. NZ$1.2M; 2012-2014. Bellomo R, Myburgh J.A. Finfer SR, Cooper DJ, $2.5M; 2010-2015. Health Research Council of New Zealand, Randomised trial of hydrocortisone in critically ill patients with septic shock NHMRC, A phase IIB randomised controlled trial (ADRENAL) Principal Investigators: McArthur C, Venkatesh of continuous beta-lactam infusion compared with B, Young P, McGuinness S, Williams A, Freebairn R, intermittent beta-lactam dosing in critically ill patients Henderson S, Finfer S, Myburgh J.A. NZ$773 854; 2012- (BLING) (Project Grant: 1022460) Principal Investigators: 2016 Lipman J, Webb S, Dulhunty J, Paterson D, Roberts J, Myburgh J.A. (Associate Investigator) $915 978; 2012- Research Projects in Progress 2017. A retrospective audit of practice of Total Parenteral NHMRC, Practitioner Fellowship (1020204) Principal Nutrition (TPN) at a major teaching hospital in Australia. Investigator: Myburgh J.A. $374 220; 2012-2016. Principal Investigators: Patil M, Macintrich I, Scoolbread E, Honda Corporation to St George Medical Research Wilson V, Deshpande K. Foundation, The Honda Foundation Trauma and Critical Care Research Program, Principal Investigators: Myburgh ADRENAL, (Adjunctive corticosteroid treatment in critically J.A, Langcake M, Curtis K, Saxena M. $150 000; 2011- ill patients with septic shock. Principal Investigators: 2013. Myburgh J Saxena M.K.

Intensive Care Foundation The ANZICS Clinical Trials Antimicrobial Stewardship in Intensive Care Unit: Is it Group Point Prevalence Program, Principal Investigators: possible to demonstrate achievement of all Primary Goals? Seppelt I, Webb S, McArthur C, Elliot R, Myburgh JA, Principal Investigators: Adhikari S, Konecny P, Taylor P, Piza Glass P, Taylor C. $31 000; 2012. M, Lam D, Deshpande K.

Australian and New Zealand College of Anaesthetists. BLING ll, (Beta-Lactam Infusion Group), Principal An exploratory study of perceived risks, benefits and Investigators: Cheng A, Saxena M.K, Adhikari S barriers to the use of Selective Decontamination of the CELCIUS, (Comparison of core and peripheral temperature Digestive Tract in Australasian ICUs (SuDDICU), Principal measurement in adult critically ill patients with brain Investigators: Seppelt I, Marshall A, Myburgh JA, Lipman injury). Principal investigators: Liu A, Saxena M.K, Myburgh J, Francis G, Cuthbertson B, Glass P. $40 000; 2012-2013. J, Miller J, Inskip D.

Intensive Care Foundation, A randomised placebo- Characteristics and predictors of mortality in elderly controlled trial of intravenous paracetamol in febrile patients (≥ 85 years) admitted to a tertiary ICU in Australia, patients (HEAT Study), Principal Investigators: Beasley Principal Investigators: Kapalli T, Deshpande K. R, McGuiness S, Freebairn R, Van Haren F, McArthur C, Bellomo R, Myburgh J.A, Saxena M, Webb S, Weatherall COMFORT – Communication with families regarding M, Henderson S. $20 000; 2013-2014. Organ and Tissue Donation after Death in ICU, Principal Investigatosr: A Cheng A, Costello C. 32 CHEST, (Crystalloid versus Hydyroxyethyl Starch Trial), Thanakrishnan G for the Influenza Pandemic ICU Triage Principal investigators: Myburgh J.A, Saxena M.K. Study Investigators. A multicentred evaluation of two Intensive Care Unit triage protocols for use in an influenza Topic: Early temperature elevation and functional survival pandemic. Medical Journal of Australia, 2012; 197: 178- at 24 months after traumatic brain injury: Retrospective 181. analysis of the multi-centre cohort of the SAFE trial. , Principal investigatosr: Liang S, Saxena M.K, Finfer S, Dulhunty J., Roberts J., Davis J., Webb S., Bellomo R., Billot L, Myburgh J.A Gomersall C., Shirwadkar C., Eastwood G., Myburgh J.A., Paterson D., Lipman J. (2013). Continuous infusion of beta- HEAT, (Permissive Hyperthermia Through Avoidance lactam antibiotics in severe sepsis: a multicentre, double- of Paracetamol in Known or Suspected Infection in ICU blind, randomised controlled trial. Clinical Infectious Principal Investigators: (Co-Chief Investigator - Saxena Diseases 56: 236-244. M.K), Myburgh J.A Gattas D., Dan A., Myburgh J.A., Lo S., Billot L., Finfer Family Satisfaction Survey, Principal Investigators: S for the CHEST Management Committee. Fluid Achchige M, Deshpande K, Jacques T, Bikou T, Nolan D. resuscitation with 6% Hydroxyethyl starch (130/0.4) in Nephro Protective Trial, (Nephroprotective effects of L acutely ill patients – an updated systematic review and amino acids in critically ill patients), Principal investigator: meta-analysis. Anaesthesia and Analgesia, 2012; 114: 159- Jacques T. 169.

PARITY, (The Paracetamol after Traumatic Brain Injury Myburgh J.A., Li Q., Heritier S., Dan A., Glass P for the study), Principal investigators: Saxena M.K, Taylor C, Crystalloid versus Hydroxy-Ethyl Starch Trial Management Myburgh J.A. Glass P, Gowardman J, Lipman J. Committee. ‘Statistical analysis plan for the Crystalloid versus Hydroxy-Ethyl Starch Trial. Critical Care and Sodium Balance Study, Principal Investigators: Saxena Resuscitation, 2012; 14: 44-52. M.K, Miller J, Inskip D. Myburgh J.A. (2012). The role of hydroxyethyl starch for Study of Communication Practices in ICU, Principal resuscitation in the ICU. Critical Care and Resuscitation, Investigators: S Jones, J Bothe. 2012; 14:251 (Editorial).

TEAM, (Trial of Early Activity and Mobilisation), Principal Peake S., Chapman M., Davies A., Moran J., O’Connor S., Investigators: Saxena M.K. Chaseling W. Ridley E., Williams P for the George Institute for Global Health and the Australian and New Zealand Intensive The SANITY Survey - A Survey of Temperature Care Society Clinical Trials Group. (Myburgh J.A.: Management After Traumatic Brain Injury - Evaluating the Principal Investigator: St George Hospital; Management Potential Role of NSAIDs. Principal Investigators: Deol K, Committee Point Prevalence Program). Enteral nutrition in Saxena M.K, Myburgh J.A. Australian and New Zealand Intensive Care Units: a point TTM, (Target Temperature Management after Cardiac prevalence study of prescription practices. Critical Care Arrest Trial), Principal investigators: Saxena M.K, Myburgh and Resuscitation, 2012; 14:158-153. J.A. Skowronski GA, Peisah C. The greying intensivist: ageing TRANSFUSE, (Standard Issue Transfusion versus and medical practice - everyone’s problem. Med J Aust. Fresher Red Blood cells use in Intensive Care), Principal 2012 May 7;196 (8):505-7. Investigators: Deshpande K, Saxena M.K. The RENAL Study Investigators. (Myburgh J.A.: Member Original Peer-Reviewed Publications Writing Committee). Fluid balance and patient outcomes in the Randomised Evaluation of Normal vs Augmented 2012 Level of renal replacement therapy trial. Critical Care Medicine, 2012; 40: 1753-1760. Cheung W., Myburgh J.A., Seppelt I., Parr M.J., Blackwell N., DeMonte S., Ghandi K., Hoyling L., Nair Taylor C., Jan S., Curtis K., Tzannes A., Li Q., Palmer P., Passer M., Reynolds C., Saunders N.M., Saxena M.K., C., Dickson C., Myburgh J.A. The cost-effectiveness of Thanakrishnan G for the Influenza Pandemic ICU Triage physician-staffed hospital emergency medical service Study Investigators. Development and evaluation of an (HEMS) transport to a major trauma centre in NSW, influenza pandemic ICU triage protocol. Critical Care and Australia. Injury, 2012; 43: 1843-1849. Resuscitation, 2012; 14:185-189. Taylor C., Jan S., Myburgh J.A. Exploring the economics of Cheung W., Myburgh J.A., Seppelt I., Parr M.J., helicopter rescue in Australia. Medical Journal of Australia, Blackwell N., DeMonte S., Ghandi K., Hoyling L., Nair 2012; 197: 488-490. P., Passer M., Reynolds C., Saunders N.M., Saxena M.K., 33 Taylor C., Liu B., Bruce E., Burns B., Jan S., Myburgh St George Hospital). Sodium administration in critically ill J.A, Primary scene responses by Helicopter Emergency patients in Australia and New Zealand: a multicentre point Medical Services in New South Wales, Australia 2008- prevalence study. Critical Care and Resuscitation, 2013; 2009. BMC Health Services Research, 2012; 12:402 15: 294-300.

Willenberg L., Curtis K., Taylor C., Jan S., Glass P., Bradford C., Finfer S., O’Connor A., Yarad E., Firth R., Myburgh J.A. Variation of acute treatment costs of trauma McCallister R., Harrington T., Steinfort B., Faulder K., in high-income countries. BMC Health Services, 2012; 12: Assaad N., Morgan M. (Myburgh J.A.: Chair: Data 267. Monitoring Committee). A randomised-controlled trial of induced hypermagnesaemia following aneurysmal Yastrebov K, Sader M, Youssef G, et al. Dynamic subarachnoid haemorrhage. Critical Care and Echocardiography in Evaluation of Platypnea-Orthodeoxia. Resuscitation, 2013; 15: 119-125. AJUM: 2012 May 15(2)72-76. Cooper D.J., Myburgh J.A., Bellomo R., Billot L., Finfer Young P., Hodgson C., Dulhunty J., Saxena M., Bailey S., Heritier S., Murray L., Vallance S., for the SAFE- M., Bellomo R., Davies A., Finfer S., Kruger P., Lipman TBI Investigators and the Australian and New Zealand J., Myburgh J.A., Peake S., Seppelt I., Streat S., Tate R., Intensive Care Society Clinical Trials Group. Albumin Webb S for the ANZICS Clinical Trials Group. Endpoints resuscitation for traumatic brain injury – is intracranial for phase II trials in intensive care: recommendations from hypertension the cause of increased mortality? Journal of the Australian and New Zealand Intensive Care Society Neurotrauma, 2013; 30: 512-518. Clinical Trials Group consensus panel meeting. Critical Care and Resuscitation, 2012; 14:211-215. Dulhunty J., Roberts J., Davis J., Webb S., Bellomo R., Gomersall C., Shirwadkar C., Eastwood G., Myburgh Young P., Saxena M., Beasley R., Bellomo R., Bailey M., J.A., Paterson D., Starr T., Udy A., Paul S., Lipman J and Pilcher D., Finfer S., Harrison D., Myburgh J.A., Rowan the Australian and New Zealand Intensive Care Society K. Early peak temperature and mortality in critically Clinical Trials Group and Australasian Society for Infectious ill patients with and without infection. Intensive Care Diseases Clinical Research Network. A protocol for a Medicine, 2012; 38: 437-444. multicentre randomised-controlled trial of continuous Young P., Saxena M., Andrews L., Bellomo R., Freebairn beta-lactam infusion compared with intermittent beta- R., Henderson S., McArthur C., McGuinness S., Mackle lactam dosing in critically ill patients with severe sepsis: D., Myburgh J.A., Van Haren F., Weatherall M., Webb S., the BLING II study. Critical Care and Resuscitation, 2013; Beasley R and the ANZICS Clinical Trials Group. The HEAT 15:179-185. trial: a protocol for a phase IIb multi-centre randomised Gattas D., Dan A., Myburgh J.A., Billot L., Lo S., Finfer placebo-controlled trial of intravenous paracetamol in S., for the CHEST Management Committee. Fluid intensive care patients with fever and infection. Critical resuscitation with 6% hydroxyethyl starch (130/0.4) Care and Resuscitation, 2012; 14:290-296 [Correction: in acutely ill patients: systematic review of effects on Critical Care and Resuscitation 2013: 15: 133]. mortality and treatment with renal replacement therapy. 2013 Intensive Care Medicine, 2013; 39: 558-568.

Barker CL, Costello C, Clarke PT. Obstetric Air Medical Hammond N., Saxena M., Taylor C., Young P., Seppelt I., Retrievals in the Australian Outback. Air Medical Journal Glass P., Myburgh J.A., for the George Institute for Global 2013, 32(6): 329-33. Health and ANZICS Clinical Trials Group. Temperature management of non-elective intensive care patients Bellomo R., Lipscey M., Calzavacca P., Haase M., Haase- without neurological pathology: a point prevalence study Felitz A., Licari E., Cole L., Cass A., Finfer S., Gallagher M., of practice in Australia and New Zealand. Critical Care and Lee J., Lo S., McArthur C., McGuiness S., Myburgh J.A., Resuscitation, 2013; 15:228-233. Scheinkestel C for the RENAL Study Investigators and the Australian and New Zealand Intensive Care Society Clinical Myburgh J.A., Finfer S. Causes of death after bolus fluid Trials Group. Early acid-base and blood pressure effects of resuscitation: new insights from FEAST. BMC Medicine, continuous renal replacement therapy intensity in patients 2013; 11:67 (Editorial). with metabolic acidosis. Intensive Care Medicine, 2013; Myburgh J.A., McIntyre L. New insights in fluid 39: 429-326. resuscitation. Intensive Care Medicine, 2013; 39: 998-1001 Bihari S., Peake S., Seppelt I., Williams P., Bersten A., (Editorial). on behalf of the George Institute for Global Health and Myburgh J.A. Advances in fluid resuscitation in critically ill the Australian and New Zealand Intensive Care Society patients: implications for clinical practice. Current Opinion Clinical Trials Group. (Myburgh J.A.: Principal Investigator, in Critical Care, 2013; 19: 278-291 (Editorial). 34 Myburgh J.A. Review: Hydroxyethyl starch increases statistical analysis plan for the HEAT trial: a multi-centre mortality and acute kidney injury in critically ill patients. randomised placebo-controlled trial of intravenous Annals of Internal Medicine, 2013; 158: JC4. paracetamol in intensive care patients with fever and infection. Critical Care and Resuscitation, 2013; 15:279- Nair P., Center J., Eisman J., Nguyen N., Myburgh J.A., 286 Cylee P., Reynolds C. Significant perturbation of vitamin D-parathyroid-calcium axis and adverse clinical outcomes Other Published Material in critically ill patients. Intensive Care Medicine, 2013; 39: 267-274. 2012

Nielsen N., Wetterslev J., Cronberg T., Erlinge D., Gasche Douglas B, Morarty J, Saxena M K (2012) Traumatic Y., Hassager C., Horn J., Hovdenes J., Kjaegaard J., Kuiper Brain Injury In: Emergency and Trauma Care for nurses M., Pellis T., Stammet P., Wanscher M., Wise M., Aneman and paramedics. (Curtis K, Ramsden C). Sydney: Mosby A., Al-Subaie N., Boesgaard S., Bro-Jeppsen J., Brunetti Elsevier. pp 1169-1192. I., Bugge J., Hingston C., Juffermans N., Koopmans M., 2013 Kober L., Langorgen J., Lilja G., Moller J., Rundgren M., Rylander C., Smid O., Werer C., Winkel P., Friberg H for Gordon A., Myburgh J.A. (2013). Vasodilators and the TTM investigators. (Myburgh J.A.: Study Director, antihypertensives. In: Oh’s Intensive Care Manual 7th George Institute for Global Health, Saxena M: Site PI ). edition. (Bersten A.D., Soni N. eds). London: Butterworth Targeted temperature management at 33oC versus 36oC Heinemann Elsevier. pp. 923-936. after cardiac arrest. New England Journal of Medicine, 2013; (Published online 17 November 2013). Myburgh J.A., Saxena M.K. (2013). Severe Head Injury. In: Oh’s Intensive Care Manual 7th edition. (Bersten A.D., Parke R., Eastwood G., McGuinness on behalf of the Soni N. eds). London: Butterworth Heinemann Elsevier. pp. George Institute for Global Health and the Australian and 762-776. New Zealand Intensive Care Society Clinical Trials Group. (Myburgh J.A.: Principal Investigator). Oxygen therapy Myburgh J.A. (2013). Inotropes and vasopressors. In: Oh’s in non-intubated adult intensive care patients: a point Intensive Care Manual 7th edition. (Bersten A.D., Soni N. prevalence study.’ Critical Care and Resuscitation, 2013; eds). London: Butterworth Heinemann Elsevier. pp. 912- 15: 287-293. 922.

Saxena M.K. Taylor C., Hammond N., Young P., Seppelt I., Skowronski G. Saxena M. (2013). Neuromuscular Glass P., Myburgh J.A. for the George Institute for Global Disorders. In: Oh’s Intensive Care Manual 7th edition. Health and the ANZICS Clinical Trials Group. Temperature (Bersten A.D., Soni N. eds). London: Butterworth management in patients with acute neurological lesions: Heinemann Chapter 57. an Australian and New Zealand point prevalence study. Presentations at Scientific Meetings and Critical Care and Resuscitation, 2013; 15: 110-118. Conferences Venkatesh B., Myburgh J.A., Finfer S., Webb S., Cohen 2012 - International J., Bellomo R., McArthur C., Joyce C., Rajbhandari D., Glass P., Harward M and the ANZICS Clinical Trials Group Gallagher M., Bellomo R., Cass A., Gattas D., Lee J., Lo Investigators. The ADRENAL Study protocol: Adjunctive S., McGuinness S., Myburgh J.A., Parke R. October 2012 corticosteroid tREatment iN criticAlly iLl patients with (San Diego, USA). Long term outcome of severe AKI: the septic shock. Critical Care and Resuscitation, 2013; 15: results of the POST-RENAL study. American Society of 83-87. Nephrology: Kidney Week 2012.

Yastrebov K, McLean A: Establishment of Critical Care Hammond N., Saxena M.K. Young P., Taylor C., Seppelt Echocardiography Laboratory. Crit Care 2013; 17 Sup2, I., Glass P., Myburgh J.A. Temperature management S69, P184. for patients without brain injury in Australia and New Zealand Intensive Care Units: a point prevalence survey. A Yastrebov K, Kapalli T: Malposition of Double Lumen survey of fever management in febrile critically ill patients Bicaval Venovenous Extracorporeal Membrane without neurological injury. 32nd International Symposium Oxygenation (VV ECMO) cannula resulting in hepatic on Intensive Care and Emergency Medicine Brussels, venous congestion. AJUM, November 2013. Belgium. March. Young P., Weatherall M., Saxena M., Bellomo R., Freebairn Myburgh J.A. The case for randomised-controlled trials for R., Hammond N., Van Haren F., Henderson S., McArthur fluid resuscitation. Round Table Conference: International C., McGuinness S., Mackle D., Myburgh J.A., Webb S., Symposium on Intensive Care and Emergency Medicine. Beasley R and the ANZICS Clinical Trials Group. The Brussels, Belgium. March. 35 Myburgh J.A. Report of the Round Table Conference: Care Forum. Toronto, Canada, November. Types of intravenous fluids. International Symposium Yastrebov K. Visiting Professor in Intensive Care, on Intensive Care and Emergency Medicine. Brussels, Hospital Ambroise Pare. Paris, France, June. Belgium. March. Willenberg L., Curtis K., Taylor C., Jan S., Glass P., Myburgh J.A. The CHEST study. International Symposium Myburgh J.A. Variation of acute treatment costs of trauma on Intensive Care and Emergency Medicine. Brussels, in high-income countries. London Trauma Conference. Belgium. March. London, UK, November. Myburgh J.A. I believe in adrenaline. International 2012 - National Symposium on Intensive Care and Emergency Medicine. Gallagher M., Bellomo R., Cass A., Finfer S., Gattas D., Myburgh J.A. The Crystalloid vs Hydroxyethyl Starch Trial. Lee J., Lo S., McGuinness S., Myburgh J.A., Parke R., 11th Congress in Evidence Based Perioperative Medicine Rajbhandari D. Long term outcome of severe AKI: the and the Great World Fluid Debate. London, UK July. results of the POST-RENAL study. Australian and New Myburgh J.A. Unanswered questions in fluid management. Zealand Society of Nephrology Annual Scientific Meeting. 11th Congress in Evidence Based Perioperative Medicine Melbourne, August. and the Great World Fluid Debate. London, UK July. Ito A., Lam D., Deshpande K. Bacteraemia in Intensive Myburgh J.A. Fluid resuscitation with 6% HES (130/0.4)/ Care Unit: Temporal trends in epidemiology and vs normal saline: The CHEST trial. Hot topics session: antimicrobial susceptibility. College of Intensive Care European Society of Intensive Care Medicine Annual Medicine Annual Scientific Meeting. Melbourne, June. Scientific Meeting. Lisbon, Portugal, October. Myburgh J.A. Sustainable Intensive Care. Bush Track to Myburgh J.A. The CHEST trial. Critical Care Canada Boulevard: College of Intensive Care Medicine Rural and Forum. Toronto, Canada, October. Regional Meeting. Byron Bay, March.

Myburgh J.A. Pressors, inotropes and fluids: do our Myburgh J.A. CHEST update. Australian and New choices really matter? Critical Care Canada Forum Zealand Intensive Care Society Clinical Trials Group Annual Residents’ Day. Toronto, Canada, October. Scientific Meeting. Noosa, March.

Myburgh J.A. Development of a definitive RCT of steroids Myburgh J.A. NICE-SUGAR TBI - results. Australian and in critically ill patients. Critical Care Canada Forum. New Zealand Intensive Care Society Clinical Trials Group Toronto, Canada, October. Annual Scientific. Noosa, March.

Myburgh J.A. Fluid resuscitation in specific patient Myburgh J.A. The CHEST trial results. Australian and New populations: sepsis and traumatic brain injury. Critical Care Zealand Intensive Care Society Clinical Trials Group Winter Canada Forum. Toronto, Canada, October. Research Forum. Melbourne, July.

Myburgh J.A. The CHEST trial. International Sepsis Forum. Myburgh J.A. A fluid movement in acute medicine. St Paris, France, November. George Hospital, Malcolm Schonnel Memorial Lecture. Sydney, February. Myburgh J.AType of intravenous fluids. .. Conferences de soins intensifs et de medecine d’urgence: Hopital Erasme. Myburgh J.A. Inotropes and vasopressors. Crit IQ: Brussels, Belgium, November. podcast. May 2012.

Myburgh J.A. Resuscitation fluids: past, present, future. Myburgh J.A. Fluid resuscitation – new developments. University of Birmingham, UK, November. Sydney Intensive Care Network, May.

Saxena M.K. Young P., Bailey M., Pilcher D., Beasley Saxena M.K. The CLARITY study –Understanding R., Bellomo R., Finfer S., Myburgh J.A. Early peak “normothermia” after TBI and stroke. The Clinical Trials temperature and mortality in critically ill patients with Group of the Australia and New Zealand Intensive Care acute neurological pathology. Canadian Critical Care Society: Annual Scientific Meeting Noosa, March. Forum. Toronto, Canada, November. Saxena M.K. Normothermia for Acute Neurological Saxena M.K. Taylor C., Hammond N., Bellapart J., Skirfvars Pathology: is a RCT feasible / CLARITY Update. The M., Loh A., Nayyar V., O’Leary M., Rajbandhari D., Hardie Clinical Trials Group of the Australia and New Zealand M., Rashid A., Seppelt I., Glass P., Myburgh J.A. Defining Intensive Care Society: Annual Scientific Meeting normothermia for traumatic brain injury: and Australian Adelaide, October. multicentre retrospective cohort study. Canadian Critical 36 Saxena M.K. Normothermia and Acute Brain Injury. Hammond N., Taylor C., Liu B., Finfer S., Glass P., Saxena Nepean Hospital: Intensive Care Seminar. Sydney, April. M., Seppelt I., Willenberg L., Myburgh J.A. for the Australian and New Zealand Intensive Care Society Clinical Saxena M.K. Establishing Early Medical Consensus … Trials Group and the George Institute for Global Health. St. George Hospital: Medical Morbidity and Mortality October 2013. Fluid resuscitation practices in Australia Meeting Sydney, May. and New Zealand intensive care units. European Society of Saxena M.K. Normothermia and Acute Brain Injury. St Intensive Care Medicine Annual Scientific Meeting. Paris, Vincent’s Hospital: Intensive Care Seminar Sydney, June. France.

Saxena M.K. To Cool or Not to Cool … (Sepsis). St. Jacques T. February 2013, Introducing a bended learning George and Sutherland Nursing Symposium. Sydney, programme to front -line staff: Plenary Speaker at the September. inaugural National Japanese Medical Simulation Meeting Okinawa, Japan. Saxena M.K. Normothermia and Acute Brain Pathology, St George and Sutherland Nursing Symposium. Sydney, Myburgh J.A. May 2013. Why we need a definitive trial September. on steroids. Chinese Society of Critical Care Medicine. Xiamen, China. Saxena M.K. Current Cooling Practices in Intensive Care Normothermia and Acute). St. George and Sutherland Myburgh J.A. May 2013. Colloids in critical care: an Nursing Symposium. Sydney, September. analysis of recent trials. Chinese Society of Critical Care Medicine. Xiamen, China. Saxena M.K. The management of Traumatic Brain Injury. Advanced Trauma Nursing Sydney, October. Myburgh J.A. June 2013. Decompressive craniectomy: never for anything? College of Intensive Care Medicine Saxena M.K., Taylor C., Hammond M., Young P., Seppelt Annual Scientific Meeting. Wellington, NZ I., Glass P., Myburgh J.A. Temperature management after acute brain injury: a point prevalence study of practice Myburgh J.A. March 2013. Albumin in brain oedema. in Australia and New Zealand. Australian and New International Symposium on Intensive Care and Zealand Intensive Care Society Annual Scientific Meeting. Emergency Medicine. Brussels, Belgium. Adelaide, October. Myburgh J.A. March 2013. PRO: Synthetic colloids should Saxena M.K. Taylor C., Hammond N., Bellapart J., Skirfvars be abandoned. International Symposium on Intensive Care M., Loh A., Nayyar V., O’Leary M., Rajbandhari D., Hardie and Emergency Medicine. Brussels, Belgium M., Rashid A., Seppelt I., Glass P., Myburgh J.A. Defining Myburgh J.A. March 2013. Optimal design for clinical normothermia for traumatic brain injury: An Australian trials. International Symposium on Intensive Care and multicentre retrospective cohort study. Australian and New Emergency Medicine Brussels, Belgium. Zealand Intensive Care Society Annual Scientific Meeting 2012. Adelaide, October. Myburgh J.A. March 2013. The CHEST Trial: further analyses. International Symposium on Intensive Care and Yastrebov K. Presenter Advanced course on Critical Care Emergency Medicine Brussels, Belgium. Echocardiography. Leura, NSW, August. Myburgh J.A. July 2013. The evidence for the use of 2013 - International vasopressors in critically ill patients. Singapore-ANZICS Doolan H., Jacques T., Mackertich M., Stirling A., Intensive Care Forum. Singapore. Fernandez R. May 2013, Examining the prevalence Myburgh J.A. July 2013. Hydroxyethyl starch for fluid and outcomes of patients with signs of documented resuscitation in critically ill patients. Singapore-ANZICS early deterioration, a comparison of two models. 8th Intensive Care Forum. Singapore. International Rapid Response Conference. Royal College of Physicians, London UK. Myburgh J.A. July 2013. The case for a definitive trial of steroids in septic shock. Singapore-ANZICS Intensive Care Hammond N., Taylor C., Liu B., Finfer S., Glass P., Forum. Singapore. Saxena M., Seppelt I., Willenberg L., Myburgh J.A. for the Australian and New Zealand Intensive Care Society Myburgh J.A. August 2013. A renal-safe colloid: a pipe Clinical Trials Group and the George Institute for Global dream? 11th World Federation of Intensive and Critical Health. May 2013. Fluid resuscitation practices in Australia Care Medicine Meeting. Durban, South Africa. and New Zealand intensive care units – preliminary data. Myburgh J.A. August 2013. Should we move away from College of Intensive Care Medicine Annual Scientific God’s only inotrope? Adrenaline vs noradrenaline? 11th Meeting. Wellington, NZ. World Federation of Societies of Intensive and Critical 37 Care Medicine Meeting. Durban, South Africa. Adhikari S Antimicrobial Stewardship in Intensive Care Unit: Three year Evaluation of a Multidisciplinary Model. Myburgh J.A. August 2013. Adrenaline and noradrenaline Australian Society of Antimicrobials: Sydney. and the heart. 11th World Federation of Societies of Intensive and Critical Care Medicine Meeting. Durban, Jones S Pressure Injury Prevention in the Critically Ill South Africa. Adult: 2nd Annual Reducing Avoidable Pressure injuries Conference Melbourne. Myburgh J.A. August 2013. (Durban, South Africa). The CHEST trial – further questions. 11th World Federation of Kapalli T, Deshpande K. Characteristics and predictors Societies of Intensive and Critical Care Medicine Meeting. of mortality in elderly patients (≥ 85 years) admitted to a tertiary ICU in Australia. College of Intensive Care Myburgh J.A. September 2013. Our evolving knowledge Medicine Annual Scientific Meeting. Wellington, NZ, June. of fluid options. Baxter Satellite Meeting: European Society of Intensive Care Medicine Annual Scientific Liu A., Saxena M.K, Myburgh J.A. The CELSIUS Study. St Meeting. Paris, France. George and Sutherland Hospitals Medical Symposium. Sydney, October. Myburgh J.A. September 2013. Commentary: Computerised tight vs. conventional glycaemic control in Myburgh J.A. Further results from the CHEST trial. critically ill patients. President’s sessions: European Society Australian and New Zealand Intensive Care Society Clinical of Intensive Care Medicine Annual Scientific Meeting. Trials Group Annual Scientific Meeting. Noosa, March. Paris, France. Myburgh J.A. Fluid resuscitation: which, when and how Saxena M.K. Taylor C., Hammond N., Bellapart J., much? SMACC: Social media and Critical Care. Sydney, Skirfvars M., Loh A., Nayyar V., O’Leary M., Rajbandhari March. D., Bradford C., Hardie M, Rashid A., Seppelt I., Glass Myburgh J.A. Catecholamines: resuscitation or P., Myburgh J.A. March 2013. Defining normothermia resurrection: fact or fiction. SMACC: Social media and for traumatic brain injury: an Australian multicentred Critical Care. Sydney, March. retrospective study. 33rd International Symposium on Intensive Care and Emergency Medicine. Brussels Myburgh J.A. Fluid resuscitation. Royal Prince Alfred Belgium. Hospital. Sydney, November.

Saxena M.K. 2013. The CHEST Study. French society of Saxena M.K. A protocol for a conservative fluid Critical Care Medicine . Paris, France. randomised clinical study. The Clinical Trials Group of the Australia and New Zealand Intensive Care Society: Annual Saxena M.K. 2013. Future Directions for the Australia Scientific Meeting. Melbourne, August. and New Zealand Intensive Care Society. French society of Critical Care Medicine. Paris, France. Saxena M.K. Core Outcome Measure Sets for Critical Care Trials: a report from the International Sepsis Forum/ Saxena M.K. 2013. How to understand Controversial International Forum of Acute Care Triallists Sepsis Studies. French society of Critical Care Medicine. Paris, France. Colloquium. The Clinical Trials Group of the Australia and New Zealand Intensive Care Society: Annual Scientific Saxena M.K. 2013 Doctor, please feed me ... I am starving Meeting. Melbourne, August. to death. The 2nd Singapore ANZICS Intensive Care Forum, Singapore. Saxena M.K. Does a conservative fluid strategy compared to “Usual fluid management” improve outcomes for Saxena M.K. 2013 Fever for sepsis: better to be hot than critically ill patients? The Clinical Trials Group of the cool. The 2nd Singapore ANZICS Intensive Care Forum Australia and New Zealand Intensive Care Society: Annual Singapore, Scientific Meeting. Noosa, March. Yastrebov K. March 2013. Establishing Critical Care Saxena M.K Current and future fluid trials in resuscitation, Echocardiography Laboratory. 33rd International Australia and New Zealand Intensive Care Society, Symposium on Intensive Care. Brussels, Belgium. Australian College of Critical Care Nurses, Annual Scientific Meeting. Hobart, October.

Yastrebov K. March 2013. Instructor: Basic and Advanced Saxena M.K. The importance of corporate + philanthropic Courses on Critical Care Echocardiography. Brussels, support in improving the health of patients in Australia and Belgium. New Zealand. Intensive Care Foundation, Feburary.

2013 - National Seppelt I., Marshall A., Dan A., Cole L., Weisbrodt L., 38 Glass P., Myburgh J.A., Finfer S., Lipman J., Francis J., International collaborations Cuthbertson B. An international Delphi study examining 1. Round Table Conference: Types of intravenous the perceived risks, benefits and barriers to the use of fluids. International Symposium on Intensive care and selective decontamination of the digestive tract (SDD) in Emergency Medicine. (Chairman). Brussels. 2012. intensive care. Australian Society of Infectious Disease Annual Scientific Meeting. Canberra, March. 2. Faculty of Intensive Care Medicine, United Kingdom. Board retreat. (Invited international expert). London. Shiner E, Hersch M, Yastrebov K, Normal CSF in HSV 2012. Enchephalitis. Proceedings of the Australian and New Zealand Association of Neurology Annual meeting. 3. Intracranial pressure monitoring in traumatic brain Community Engagement injury Think Tank: BEST TRIPS collaborative. Seattle. 2013. Wendy Chaseling 4. Acute Dialysis Quality Initiative (ADQI XII): 12th Chair ICCMU/ACI - Best Practice Group -Suctioning Consensus Conference: Across the oceans in 2013: the Artificial Airway of the Adult ICU patient: A Clinical the fluid debate rages on. London. 2013. Practice Guideline 5. Global Fluid Management: Advisory Board Meeting to A/Prof Theresa Jacques Baxter Pharmaceuticals. Paris. 2013.

Chair Medical Staff Council St George Hospital National collaborations Chair Medical Staff Council Executive Council SESLHD 1. Clinical Trials Research Summit: The Medical Journal Member Clinical Council The St George Hospital of Australia. Sydney. 2012. Co-Chair ICCIS Workgroup ACI /Ministry of Health Member ANZICS End of Life Care work group 2. Advisory Board to Baxter Pharmaceuticals:Intravenous Chief Editor DETECT Fluids. Sydney. 2013 Donation Specialist -Medical DONATE LIFE NSW Dr Manoj Saxena ICCIS PROJECT http://vimeo.com/ Honorary Fellow, Critical Care & Trauma Division, The user19020418review/71555501/14629d34f3 George Institute for Global Health

Excellence in Clinical Collaboration: The ICCIS Project Chair: Scientific Committee – St. George and Sutherland http://vimeo.com/ Medical Research Symposium user19020418review/91390334/00ca3802e0 Committee Member: St. George and Sutherland Medical Research Symposium Jacques T, Morris R, Fraser K. Debrief for Health Care Executive Committee Member for NSW: Australia and Professionals involved in DETECT June 2013 New Zealand Intensive Care Society Clinical Trials Group

Sarah Jones Examiner: College of Intensive Care Medicine Chair ISCN (Intensive Care Services Network) Best Practice Group 1. “The CICM Examination Process from the Perspective of an Examiner” Professor John Myburgh a. The Wellington Intensive Care Medicine Member, Academic Council, St George Clinical School Course (2012 and 2013) Member: Scientific Advisory Committee, St George Medical Research Foundation b. The Nepean Hospital Written Examination President, College of Intensive Care Medicine course (2012) Practitioner Fellow: National Health and Medical Research 2. Sydney Long Course in Intensive Care Medicine Council (2012 and 2013) Council Member, World Federation of Societies of Intensive and Critical Care Medicine 3. Sydney Short Course in Intensive Care Medicine Malcolm Schonell Medal, St George Hospital 2012 (2012 and 2013)

Honour Roll, Australian and New Zealand Intensive Care 4. Nepean Written Course in Intensive Care Society 2013 Medicine (2013) St George Clinical School Research Excellence Award, University of New South Wales 2013

39 5. The Trek for Trauma (Kokoda Track, Papua New Guinea, June 2013): St George and Sutherland Medical Research Foundation

6. “A Long Walk Back” (ABC Documentary): (http:// www.abc.net.au/austory/specials/longwalkback/ default.htm) St. George and Sutherland Medical Research Foundation

7. “The importance of corporate + philanthropic support in improving the health of patients in Australia and New Zealand”. Intensive Care Foundation (Sydney, Feb 2013)

A/ Prof Konstantin Yastrebrov

Member of Steering Committee for Postgraduate Diploma of Echocardiography.

Kylie Fraser

Clinical Skills Centre Executive Member, Member Editorial Panel DETECT programme.

40 > Department of Nuclear Medicine

Head of Department Presentations at Scientific Meetings and Conferences Dr Patrick Butler MA, MD, MBA, FRACP Conjoint Associate Professor UNSW 2012 – National

Senior Medical McKay E. SPECT Quantitation of Lu-177. ANZSNM Annual Scientific Meeting, Melbourne, April 2012. Dr Scott Beuzeville BMed(Hons), FRACP Dr Richard Quinn MBBS, DDU, FRACP Browne E, McKay E, Smart RC. Radiation Safety Dr Ramy Nour MBBS, FRACP Precautions with 177Lu-Octreotate therapy. ANZSNM Annual Scientific Meeting, Melbourne, April 2012. Junior Medical R Bency, E McKay, D Farlow, Comparison of Ga-68 Dr Rosamma Bency MBBS Dotatate scanning and Lu-177 Dotatate scanning in NET Dr Parameswar Rachumulla MBBS patients undergoing PRRT. ANZSNM Annual Scientific Physicists Meeting, Melbourne, April 2012.

Dr Erin McKay PhD, MACPSEM 2013 – National Mr Casper Marciniak MSc, MACPSEM McKay E. Individual Variation in Renal Dosimetry of Lu-177 Radiochemist Octreotate. ANZSNM Annual Scientific Meeting, Perth, April 2013. Ms Effie Browne BAppSci, MScMed Marciniak C, McKay E. Implementation of a Channelised Medical Radiation Scientists Hotelling Observer. ANZSNM Annual Scientific Meeting, Perth, April 2013. Mr Peter McConachie BAppSci, MCom Mr Andrew Cluff BAppSci, MBA

Research Projects in Progress

Quantitation of Lu-177 Dotatate uptake in the treatment of neuroendocrine tumours. Principal Investigator: Dr Erin McKay.

Reproducibility of isotopic GFR measurements. Principal Investigator: Dr Patrick Butler.

41 > Department of Renal Medicine

Head of Department The role of cortisol in the development of hypertension and cardiovascular disease in chronic kidney disease Professor Mark Brown $75 000, 2012. MBBS, MD, FRACP (Professor of Medicine, UNSW) SESLHD Chronic Care Service Redesign Grant, A/Prof Ivor Senior Medical Katz Associate Professor John Kelly MBBS, MD, FRACP The development of a web-based Chronic Kidney Disease Associate Professor George Mangos MBBS, MD, FRACP Outreach Program $15 000, 2012. Associate Professor Ivor Katz MD, MBBCh, FCP(SA), BSc Amgen, Prof Mark Brown Honours, PhD, FRACP Renal Supportive Care: Patient Outcomes and Quality of Dr Sharon Ong BSc(Med), MBBS, PhD, FRACP (Conjoint Life, $74,678, 2012 Senior Lecturer, UNSW) Dr William Chan MBBS, PhD, FRACP Amgen Research Grant, A/Prof Ivor Katz Dr Parthasarathy Shanmugasundaram MBBS, DM, FRACP The development of a web-based Chronic Kidney Disease (Conjoint Lecturer, UNSW) Outreach Program, $ 60,000, 2012-2013. Dr Cathie Lane B.Pharm. B.Med FRACP,Grad Cert ULT, PhD (Conjoint Lecturer, UNSW) Research Projects in Progress Dr Frank Brennan MBBS, FRACP, FAChPM, LLB- Hypertension in chronic kidney disease (CKD) Consultant Palliative Care Medicine Dr Sharon Ong and A/Prof John Kelly Research 1. Adequacy of blood pressure control in CKD Research Fellow 2. 24 hour ambulatory and self home blood pressure Dr Franziska Pettit MB BAO Bch BMSc MRCPI FRACP monitoring in CKD

Medical Students 3. Role of glucocorticoids in hypertension in CKD

Colin Chng CKD health systems research Foong Ming Ho A/Prof Ivor Katz

Research Officers 1. 1Achievement of target BP & other risk factors on CKD patients. Saiyini Pirabhahar Paula Williamson 2. Patterns of referral for CKD Management. Gemma Collett 3. CKD to kidney failure - predictive model. Nursing & Allied Health 4. Web based CKD outreach program. Elizabeth Josland Hypertension in pregnancy Shelley Tranter Prof Mark Brown and A/Prof George Mangos, A/Prof Greg Tania Burns Davis and A/Prof Tony O’Sullivan) Jennifer Beddoe Yanella Matinez-Smith 1. The ‘new’ R-A-A system in pre-eclampsia. Coralie Meek Maria Chan 2. Body composition in normal pregnancy.

Research Grants 3. Outcomes of hypertensive pregnancies. 4. Post-partum physiology, psychology and pediatric Clive and Vera Ramaciotti Foundation Research outcomes for women with preeclampsia (the ‘P4’ Establishment Grant, Dr Sharon Ong study). 42 Renal palliative care Hawkins TL, Roberts JM, Mangos GJ, Davis GK, Roberts Dr Frank Brennan and Prof Mark Brown L, Brown MA. Plasma Uric acid remains a marker of poor outcome in hypertensive pregnancy: a retrospective cohort 1. The role of palliative care in improving quality of life analysis. British Journal of Obstetrics and Gynaecology outcomes for hospital based haemodialysis patients. 2012; 119:484–492.

2. Quality of life & symptom burden in dialysis patients. Head GA, McGrath BP, Mihailidou AS, Nelson MR, 3. Survival and symptom control of patients in Pre- Schlaich MP, Stowasser M, Mangoni AA, Cowley D, dialysis & Renal Supportive Care clinics.Outcomes Brown MA, Ruta LA, Wilson J. Ambulatory blood of patients in Pre-dialysis & Renal Supportive Care pressure monitoring in Australia: 2011 consensus position clinics. statement. Journal of Hypertension 2012, 30:253–266.

4. Retrospective and prospective studies of the effects Josland E, Brennan F, Anastasiou A, Brown MA. of a Renal Palliative care service on patients with CKD Developing and sustaining a renal supportive care service stage 4/5 and their carers. for people with end stage kidney disease. Renal Society of Australasia Journal 2012; 8(1): 12-18. 5. A study of ‘good deaths’ in dialysis patients. Mangos GJ, Spaan J, Pirabhahar S, Brown MA. Markers of Nutrition in CKD cardiovascular disease risk after hypertension in pregnancy. Maria Chan and A/Prof John Kelly Journal of Hypertension 2012, 30:351–358.

1. Relationship between nutritional status and outcome Moustakas J, Bennett P, Tranter S, Nicholson J. The needs in end stage kidney disease. of older people with advanced chronic kidney disease choosing supportive care: a review. Renal Society of Original Peer-Reviewed Publications Australasia Journal 2012, 8(2) 70-75.

2012 Ong SLH, Whitworth JA. Glucocorticoid-induced hypertension and the nitric oxide system. Expert Rev Brown MA. Proteinuria in pre-eclamptic pregnancy: does it Endocrinol Metab 2012; 7(3): 273-280. matter anymore? Nat. Rev Nephrol. 2012; 8:563–565. Pettit F, Brown MA. The Management of Pre-eclampsia: Brown MA, Roberts LM, Mackenzie C, Mangos G, Davis what we think we know. European Journal of Obstetrics & GK. A Prospective Randomized study of Automated Gynecology and Reproductive Biology 2012; 160: 6–12. versus mercury blood pressure recordings in hypertensive pregnancy (PRAM study). Hypertension in Pregnancy. Pianta TJ, Horvath AR, Ellis VM, Leonetti R, Moffat C, 2012;31:107-119. Josland EA, Brown MA.Cardiac high-sensitivity Troponin T measurement: a layer of complexity in managing Chan, M., J. Kelly, M. Batterham and L. Tapsell. hemodialysis patients. Nephrology. 2012; 17: 636–641. “Malnutrition (Subjective Global assessment) Scores and Serum Albumin Levels, but not Body Mass Index Values, Spaan J, Brown MA. Renin Angiotensin system in pre- at Initiation of Dialysis are Independent Predictors of eclampsia: everything old is new again. Obstetric Mortality: A 10-Year Clinical Cohort Study.” Journal of Med.2012;5: 147-153. Renal Nutrition 22(6): 547-557, 2012. Spaan J, Peeters L, Spaanderman M, Brown MA. Chan M. Nutrition, diabetes and chronic kidney disease, Cardiovascular risk management after a hypertensive Australian Diabetes Educator. Volume 15 Number 3, disorder of pregnancy. Hypertension 2012;60:1368-1373. August 2012, pp17-23. Westgarth F, Chiarella M. & Tranter S. The Haemodialysis Hawkins L-A, Brown MA, Mangos G, Davis GK. Transient Models of Care Program. Renal Society of Australasia gestational hypertension: not always a benign event. Journal 2012, 8(1) 24-31. Pregnancy Hypertension. 2012; 2: 22-27.

43 2013

Brennan FP. “Clock without Hands”. American Journal of Josland, E. Quality of Life. What information is already Hospice and Palliative Medicine 2013; 30(3):312-316. available and what evidence is this based on? Nephrology, 2013c: 18, 410-413. Brennan FP. Conscientious Objector – Edna St Vincent Millay, mortality and the nature of Palliative Care. Journal Lim CED, Siow S, Ho KEH, Chua JL, Chong N, Cheng L, of Palliative Care 2013; 29(2): 123-125. Kwok, Brennan FP, Cigolini M. Advance Care planning in haemodialysis patients. Protocol Information. Cochrane Brennan FP, Brown M. An ethical approach to dialysis – an Reviews. Review number 294. September 2013. alliance of Nephrology, Palliative Medicine and ethics. Quarterly Journal of Medicine 2013; 106(5): 397-400. Ong SLH, Vohra H, Zhang Y, Whitworth JA. The role of mitochondrial superoxide in glucocorticoid-induced Brennan FP. The New World of Ourselves. Journal of hypertension. Oxid Med Cell Longev 2013; 2013:517045. Palliative Care 2013; 29(4): 258-259. Pettit F & Ong SLH. Management of Hypertension in Brennan FP. Ethical Principles for Patients, Families and Pregnancy. eMIMS Disease Index. Revision August 2013. Doctors to Consider. Nephrology 2013; 18: 413-414. Prabhu A, Taylor P, Konecny P, Brown MA. Pyelonephritis: Brennan FP, Siva B, Crail S. Appropriate Assessment of What are the present day causative organisms and Symptom Burden and Provision of Patient Information. antibiotic susceptibilities? Nephrology. 2013;18(6):463-7. Nephrology 2013; 18: 418-421. Siva B, Brennan FP. Inappropriate Interventions in the Brennan FP. Holistic Palliative Care Approach - Physical, Dying Patient. Nephrology 2013; 18: 423-424. Spiritual, Religious and Psychological Needs. Nephrology 2013;18: 421-423. Spaan J, Bowyer L, Lazzaro V, McCrohon J, Brown MA. Maternal hemodynamics influence fetal hemodynamics Brennan FP, Murrell DF. Report from the Inaugural in normal and hypertensive pregnancy. Pregnancy Australian Pruritus Symposium, Sydney, Australia, August Hypertension: An International Journal of Women’s 10 2013. Acta Derm Venereol 2013. Oct 24 (Epub ahead Cardiovascular Health. 2013; 3:10–15. of print). Spaan J, Brown MA. Can we protect the kidneys after Brown MA. Is there a role for ABPM in Pregnancy? Clinical hypertensive pregnancy? Canadian Medical Association and Experimental Physiology and Pharmacology. 2013. Journal. 2013; 185:199-200. DOI.10.1111/1440-1681.12106. Stewart C, Brennan FP. Legal Issues Concerning Brown MA, Crail SM, Masterson R, Foote C, Robins J, Katz Withholding and Withdrawal of Dialysis. Nephrology 2013; I, et al. ANZSN Renal Supportive Care Guidelines 2013. 18: 444-449. Nephrology. 2013;18(6):401-54. Tranquilli AL, Brown MA, Zeeman GG, Dekker G, Sibai BM. Burns, T. Waiting for a kidney transplant in Australia. The definition of severe and early-onset pre-eclampsia. Transplant Journal of Australasia, 2013b: 23, 10-15. Statements from the International Society for the Study Crail S, Walker R, Brown M. Renal Supportive Care of Hypertension in Pregnancy (ISSHP). Pregnancy working group. Renal supportive and palliative care: Hypertension: An International Journal of Women’s position statement. Nephrology. 2013; 18(6):393-400. Cardiovascular Health. 2013; 3: 44–47.

Cuesta, C., Blow, T. & Tranter, S. Epidermolysis bullosa:a Tranter S., Anastasiou A., Bazzi H., Burgess H. & Josland rare challenge for peritoneal dialysis nurses. Renal Society E. The renal memorial service: an important component of of Australasia Journal, 2013:9, 41-44. renal supportive care. Renal Society of Australasia Journal, 2013:9, 80-84. Foo JY, Mangos GJ, Brown MA. Characteristics of hypertensive disorders in twin versus singleton Urban K, Brennan FP. Patients who withdraw from dialysis pregnancies. Pregnancy Hypertension: An International in a Sydney centre with palliative care support: who, why, Journal of Women’s Cardiovascular Health 2013; 3:3-9. and how they die. Progress in Palliative Care. Available on-line February 1 2013. Johnson DW, Atai E, Chan M, Phoon RKS, Scott C, Tussaint N, Turner GI, Usherwood T, and Wiggins, K. KHA- CARI guideline: Early chronic kidney disease: detection, prevention and management. Nephrology 18 (2013) 340–350.

44 Other Published Material Nutrition and Metabolism in Renal Disease (ICNMRD) Honolulu, Hawaii. June. 2012 Foo JY, Mangos G, Brown MA. Characteristics of Eastabrook G, Brown MA, Sargent I. The Origins and End- hypertensive disorders in twin versus singleton Organ Consequences of Pre-eclampsia In: Von Dadelzen P, pregnancies. Oral presentation at the XVIII ISSHP World Magee L (eds): Best Practice & Research Clinical Obstetrics Congress July 9th – 12th, Geneva. Switzerland. & Gynaecology: Hypertension in Pregnancy (Issue 25.4). 2011: 435 – 447. Josland E, Collett G, Brennan F, Brown MA. HOPE: Helping Older People with End stage kidney disease. Myint TM, Brown M, Fischer E. Pregnancy and dialysis. In: Poster presentation at the BMJ International Forum Harris D, Elder G, Kairaitis L, Rangan G. (editors) Clinical on Quality and Safety in Healthcare 2012 Le Palais des Dialysis. 2nd edition. McGraw Hill. Sydney. Australia. Congrès, Paris, France; April. 2012: 90-96. Mangos GJ, Ram J, Brown M. The effect of cuff size 2013 on automated blood pressure measurement. Poster presentation at the International Society of Hypertension Burns, T. Book review: “Nutritional Management of Renal Scientific Meeting, Sydney, September. Disease”. Renal Society of Australasia Journal, 2013: 9, 143. Ong SLH, Williamson PM, Pirabhahar S, Beddoe J, Trajkovska B, Kelly JJ. Adequacy of blood pressure Chan M and Chadban S. Chapter 34: Nutritional control in chronic kidney disease. Oral presentation at the management of renal transplantation. Kopple J, International Society of Hypertension Scientific Meeting, Massry S and Kalantar-Zadeh K. Textbook of Nutritional Sydney, September. Management of Renal Disease. Third Edition. Elsevier Publishing, 2013. Ong SLH, Pirabhahar S, Trajkovska B, Cohen S, Williamson PM, Youssef G, Kelly JJ. Blood pressure, fluid volume, Chan, M and Trevino-Becerra, A. Nutrition, exercise and vascular and ventricular function in chronic kidney disease. hemodialysis. Trevino-Becerra, A. (editor) Hemodialysis Poster presentation at the International Society of Esquematica. Publisher, Prado (Mexico) and translated Hypertension Scientific Meeting, Sydney, September. into Spanish, 2013 , Campbell J, Whitworth JA, Kelly JJ. Field, D. 2013. Book review: Understanding chronic kidney Williamson PM The Effect of sustained release isosorbide mononitrate disease a guide for non-specialists. Renal Society of (Imdur) on cortisol-induced hypertension in healthy human Australasia Journal, 9, 45. subjects. Poster presentation at the International Society Josland, E. Book review “Kidney disease: From advanced of Hypertension Scientific Meeting, Sydney, September. disease to bereavement” Second edition. The Renal 2012 National Society of Australasia Journal, 2013: 9, 142.

Presentations at Scientific Meetings and Burns T. “Waiting for a kidney transplant in Australia – latest trends”. Oral presentation at the Transplant Nurses Conferences Association National Conference. Melbourne, November. 2012 International Collett G. Renal Supportive Care: Holistic care for Brown M, Roberts L, Davis G, Mangos G. The UM-101 advanced CKD patients and their families. NSW Palliative Mercury-free sphygmomanometer: a replacement for Care Conference, Dubbo, October. mercury sphygmomanometry at last? Poster presentation Cuesta C, Robinson F, Blow, T & Mangos GJ Caring for at the XVIII ISSHP World Congress. July 9th – 12th, a peritoneal dialysis patient with Epidermyolosis Bullosa. Geneva. Switzerland. Oral presentation at the RSA conference, Melbourne. Chan M et.al. Nutritional characteristics and dietary Josland E, Collett G, Foote C, Tranter S, Brennan F & intake of patients attending the pre-dialysis assessment Brown MA. Renal supportive care: holistic care for end clinic. Proceedings of the 16th International Congress stage kidney disease patients and their families. Paper of Nutrition and Metabolism in Renal Disease (ICNMRD) presented at the 40th Renal Society of Australasia Annual Honolulu, Hawaii, June. Conference, Melbourne. Chan M et.al. Self-reported appetite and intake adequacy Josland E. Hepatitis Protocol: Opening a can of worms. In patients with non-dialysis chronic kidney disease. Oral presentation at the RSA conference, Melbourne. Proceedings of the 16th International Congress of June.

45 Pirabhahar S, Robins J and Katz I. Assessment of Scientific Meeting. Fremantle, WA. October. Nephrologists’ Referrals: Preventing Burnout. Poster , Chan,M, Josland, E, Kerr E, McTaggart, S, Presentation at the 48th Australian and New Zealand Tranter, S Collett, G & Tapsell L. Nutritional profileof patients at Society of Nephrology, Auckland, New Zealand, August. enrolment to the multidisciplinary predialysis clinc 2002- Moustakas J, Bennett P, Tranter S & Nicholson J. 2012. Top 10 poster presentation at the Renal society of Supportive care: what does the ‘patient” want? Paper australasia Conference, Hobart. June. presented at the 40th Renal Society of Australasia Annual Conference, Melbourne, June. Community Engagement

2013 International A/Prof Ivor Katz is involved in the The development of a web-based Chronic Kidney Disease Outreach Program: Brown MA. Collett G, Josland EA, Brennan F. Non-dialysis improving clinical outcomes of CKD patients in the St management in the elderly: survival, symptom control and George and Sutherland area. quality of life. American Society of Nephrology Kidney Week. Atlanta. USA. November.

2013 - National

Chan, M, Tranter, S, Josland, E, Collett, G & Kelly J. 2013. Association of nurtritional status and the future choice of dialysis option in patients attending the multidisciplinary predialysis assessment clinic Top 10 poster presentation at the Renal Society of Australasia Conference Hobart. June.

Chan M, Kelly J, Batterham M and Tapsell L. Nutritional characteristics and dietary intake of patients at enrolment to the pre-dialysis assessment clinic. Dietitians Association of Australia 30th National Conference, Canberra, May.

Chan M, Kelly J, Batterham M and Tapsell L. Self-reported appetite and adequacy of energy and protein intakes in patients with non-dialysis chronic kidney disease, Dietitians Association of Australia 30th National Conference, Canberra, May 2013.

Chan M, Kelly J, Batterham M and Tapsell L. Nutritional status is associated with the future treatment choice - renal replacement therapy vs. conservative care in end stage kidney disease patients attending the multidisciplinary pre-dialysis assessment clinic. 49th Australian and New Zealand Society of Nephrology (ANZSN) Annual Scientific Meeting, September.

Cuesta, A, Tranter, S & Blow T. Taking control: addressing peritoneal dialysis related infection outcomes. Renal society of australasia Conference Hobart. June..

Pettit F, Davis G, Henry A, Mangos G, Brown MA. Is early onset pre-eclampsia worse for mother or baby? Society of Obstetric Medicine Australia and New Zealand. Annual

46 > Respiratory Medicine/Sleep Disorders St George Hospital

Head of Department influenza, isolate 164) for reducing the rate and severity of acute exacerbations in patients with moderate to Steven Lindstrom: MBBS (Hons) FRACP Conjoint lecturer severe chronic pulmonary disease. (H1-H005) Principal UNSW Investigator, Elizabeth Clark.

Senior Medical A Phase 3, randomized, double-blind, placebo-controlled Elizabeth Clark: MFRCP, MBBS (Hons) study evaluating the efficacy, safety and tolerability of Andrew Ng: MBBS, FRCP two fixed dose combinations of Aclidinium Bromide/ Con Archis: MBBS (Hons) Formoterol Fumerate compared to Aclidium Bromide/ John Moses: MBBS, FRACP Formeterol and placebo for 24 weeks treatment in patients Veronica Yozghatlian: MBBS, FRACP with moderate to severe stable chronic obstructive Frank Yan: BSc (Med) MBBS, FRACP pulmonary disease. (LAC-MD-31) Principal Investigator, Alexandra Smith: MBBS Steven Lindstrom.

Junior Medical A randomized, double-blind 12 week treatment, parallel group study to evaluate efficacy and safety of QMF149 Saidul Ansary: MBBS (150mcg/160 mcg o.d.) compared to salmeterol xinafoate/ Ajantha Ragapuran: MBBS fluticasone proprionate (50mcg/500 mcg b.i.d.) in patients Chin Goh: MBBS with chronic obstructive disease (QMF149F2202) Principal Alpanamarissa Antony: MBBS, MRCP Investigator Steven Lindstrom. Charles Prabhakar: BSC (Hons) MBBS Michael Ssentamu: MBChB; MRCP (UK) A randomized, double-blind placebo controlled study to compare the efficacy of indacaterol with that of Research Staff placebo in patients with COPD who have not previously received maintenance COPD medication, using blinded Linda O’Malley: RN, CM tiotropium as active control. (QAB2425, INITIATE) Principal Carol Gano: MND, BSc Investigator Steven Lindstrom. Jay Flack: BSC (2012; 2013) Cynthia Higgins: BSC (Nursing) (2012; 2013) A Phase 3, double-blind, multi-centre, randomized, placebo-controlled trial evaluating repeated courses of Research Projects in Progress Aztreonam for Inhalation solution in subjects with non-CF bronchiectasis and Gram-negative endobronchial infection Industry Supported (Gilead AIR-BX2) Principal Investigator, Steven Lindstrom. A Phase 3, double-blind, multi-centre, randomized, Randomized, double-blind, placebo controlled, multi- placebo-controlled trial evaluating repeated courses of centre study comparing Ciprofloxacin DPI 32.5 mg BID Aztreonam for Inhalation solution in subjects with non-CF intermittently administered for 28 days on/28 days off bronchiectasis and Gram-negative endobronchial infection or 14 days on/14 days off versus placebo to evaluate (Gilead AIR-BX1 Principal Investigator Steven Lindstrom. the time to first pulmonary exacerbation and frequency A Phase 3, multi-centre, randomized, parallel group of exacerbations in subjects with non-cystic fibrosis controlled, double-blind study to investigate the safety bronchiectasis (RESPIRE) Principal Investigator Steven of inhaled Mannitol over 12 months for the treatment of Lindstrom (temporary PI during LSL taken by Dr Lindstrom Bronchiectasis (DPM-B-305) Principal Investigator Steven was Veronica Yozghatlian. Lindstrom. Investigator initiated A multi-centre, randomized, double blind, placebo- Cardiopulmonary exercise testing and quality life controlled, parallel group, single season study to assess assessments in patients with lung cancer undergoing the efficacy and safety of HI-1640V, an enteric coated oral radiotherapy for curative intent. Principal Investigators: Vaccine tablet containing 45 mg H1-164 active substance Dr Alpanamarissa Antony, Dr Steven Lindstrom, Dr Yiauw (inactivated, whole cells of non-typeable Haemophillus 47 Chin, A/Prof Peter Graham.

Management of Pulmonary Embolism in a Hospital in the Home Setting: St George Hospital Experience Principal Investigator: Dr Alpanamarissa Antony supervised by Dr Steven Lindstrom.

Procalcitonin use in the management of Community Acquired Pneumonia – a randomised trial Principal Investigator: Dr Chin Goh, supervised by Dr Steven Lindstrom.

“Prevalence of sleep disordered breathing in an orthodontic population” ‘The Sleepy Teeth Study’ Principal Investigators: Dr Andrew Ng, Dr Chin Goh.

Presentations at Scientific Meetings and Conferences

2013 - National

Dr Alpanamarissa Antony, Management of Pulmonary Embolism in a hospital in the home setting: St George Experience,: Royal Australasian College of Physicians (RACP) Congress, Perth, May.

Dr Alpanamarissa Antony, Management of Pulmonary Embolism in a hospital in the home setting: St George Experience,: St George Hospital Symposium, Sydney.

Dr Alpanamarissa Antony, Management of Pulmonary Embolism in a hospital in the home setting: St George Experience NSW Thoracic Society of Australia and New Zealand TSANZ NSW Branch Meeting, Sydney, November (recipient of the Tracey Robinson Award for the best oral presentation).

Community Engagement

Guidelines for the management of community acquired pneumonia, 2013 Dr Steven Lindstrom Video link to rural areas in NSW (supported by Agency of Clinical Innovation).

48 > Department of Rheumatology St George Hospital

Head of Department evidence for surrogate therapeutics2008-2012 $510,00 CIA . A/Prof Allan Sturgess MB BS (UQld), PhD (UMelb), FRACP, FRCPA UNSW GOLDSTAR Principal investigators. Marissa Lassere, Senior Staff Specialist, Conjoint A/Prof Medicine UNSW Kent Johnson, Kerrie Mengersen, Mike Bradburn Clinical and statistical heterogeneity in meta-analysis, Senior Medical $40,000; 2012.

Prof Marissa Lassere MB BS (USyd), PhD (UNSW), Grad Dip UNSW GOLDSTAR, Principal investigators. Marissa Epi (Newcastle), FRACP, FAFPHM. Senior Staff Specialist, Lassere, Kent Johnson, Jessie Berlin. Intelligent Meta- Conjoint Prof. Medicine UNSW Analysis Models: Dealing With Heterogeneity, $40,000; Dr Bill Giannakopoulos BSci (Med), MB BS (UNSW), PhD 2013. (UNSW), FRACP Research Projects in Progress Senior Lecturer in Medicine UNSW, Consultant Rheumatologist St George Hospital Long term outcome in patients with rheumatoid arthritis. Lassere M, Edmonds J Portek I, Sturgess A, Baker S. Dr Ian Portek MB BS (USyd), FRACP VMO Rheumatology, St George Hospital Health-related quality of life in patients on biologic treatment for rheumatoid arthritis, psoriatic arthritis and Dr Lou McGuigan MB BS (UNSW), MD (UNSW), FRACP ankylosing spondylitis. Buchbinder R, Reid C, Lassere M, VMO Rheumatology, St George Hospital March L. Junior Medical Prevalence and predictors of all-cause hospitalization in Dr Jeff Tsai, Advanced Trainee Rheumatology, 2012 patients on biologic treatment for rheumatoid arthritis, Dr Aishwarya Sukhedo, Advanced Trainee Rheumatology, psoriatic arthritis and ankylosing spondylitis. Williams B, 2013 Lassere M, March L, Buchbinder R, Reid C.

Senior Research Incidence and predictors of tuberculosis and other serious infections in patients on biologic treatment for rheumatoid Dr Kent Johnson BA (Harvard), BA (Oxford), MD (Johns arthritis, psoriatic arthritis and ankylosing spondylitis. Hopkins) Carroll G, Buchbinder R, Lassere M, March L, Reid C.

Research Staff Incidence and predictors of malignancy in patients on biologic treatment for rheumatoid arthritis, psoriatic Sue Baker BAppSc (Biomed) (UTS) arthritis and ankylosing spondylitis. Buchbinder R, Reid C, Tanya Thompson BSc (UNSW) Lassere M, March L. Research Allied Health Why patients on biologic treatment for rheumatoid Guni Hinchey Grad Dip Sports (Germ.), Grad Dip Physio arthritis, psoriatic arthritis and ankylosing spondylitis switch Cathy Brand (B Sci Anatomy), Postgrad Dip Physio biologic agents. Williams M, Buchbinder R, Reid C, Lassere Wendy Uptin BPhysio M, March L, Staples M.

Research Grants The reliability and validity of Power Doppler ultrasound in patients with rheumatoid arthritis. Joshua F, Lassere M. NHMRC Project Grant 455467 Lassere MN, Sara T, Johnson K, Iedema R, Rubin G. Electronic portable health Development and evaluation of the Tolerability and Safety file (PHF) to promote quality of care and workflow through Questionnaire (TASQ): a patient-self report instrument of continuity of care. 2007-2012 $665,500 CIA treatment related tolerability and safety for use in clinical trials. Lassere M, Johnson K. NHMRC Project Grant 510272 Lassere MN, Johnson KR, Dunsmuir W, Galbraith S, Ward R, Hughes M. Levels of 49 50 Evaluation of a prognostic measure of rheumatoid Journal. 2013, 43 66-72 arthritis damage progression using MRI, arthroscopy and Poh M.Q.W., Lassere M., Bird P., Edmonds J. Reliability synovial membrane analysis. Kirkham B, Lassere M, Bird P, and longitudinal validity of computer-assisted methods Edmonds, Portek I. for measuring joint damage progression in subjects with An evaluation of the business, architectural, and workflow rheumatoid arthritis. Journal of Rheumatology. 2013, 40: requirements of the patient held PHF and the health- 23-29 care provider electronic medical record to understand Johnson K. Letter to the Editor regarding Marciniak: the shared information resources required to support a Clinical Trial System is Broken, BMJ 347, 16 December collaborative care model. Lassere M, Iedema R, Sara T. 2013. A randomised controlled trial to demonstrate the Lassere M.N., Johnson K.R., Schiff M., Rees D. Is blood effectiveness, acceptability, and sustainability of a patient- pressure reduction a valid surrogate endpoint for stroke held portable health file on improving patient outcomes. prevention? an analysis incorporating a systematic review Lassere M, Johnson K, Iedema R, Sara T, Rubin G, Baker S. of randomised controlled trials, a by-trial weighted errors- Investigate current statistical methods to advance in-variables regression, the surrogate threshold effect (STE) biomarker and surrogate endpoint evaluation using and the biomarker-surrogacy (BioSurrogate) evaluation simulated and real data sets that reflect limitations of schema (BSES). BMC Medical Research Methodology. data and statistical assumptions. Lassere M, Dunsmuir W, 2012, Mar 12;12:27. doi: 10.1186/1471-2288-12-27 Galbraith S, Johnson K. Presentations at Scientific Meetings and The surrogate threshold effect (STE) of C-reactive protein Conferences onradiographic progression and functional disability in rheumatoid arthritis. Johnson K, Lassere M. 2012 - International

The surrogate threshold effect (STE) of HBA1c in patients Marissa Lassere, Biomarkers and Surrogate Endpoints: with diabetes on cardiovascular events. Johnson K, Lassere Food and Drug Administration, Washington DC, USA, M. June .

The surrogate threshold effect (STE) of progression- Marissa Lassere, Biomarkers Therapeutics: Health free survival for overall survival in metastatic renal cell Technology Group, Exeter University, Exeter, England, carcinoma. Lassere M, Johnson K, Liauw W. June.

An evaluation of meta-analysis in the presence of Marissa Lassere, Biomarkers Review of Statistical Issues: heterogeneity performance (bias, accuracy and coverage) National Cancer Institute: Bethesda Maryland USA with varying trial parameters (size, number, treatment November. effect, and variability) using simulations. Johnson K, 2012 - National Lassere M, Mengersen K, Berlin J. Marissa Lassere Australian Rheumatology Database: What A randomised controlled trial of a treat to target strategy we can learn from Biologics Registries. NSW Australian versus usual care in patients with rheumatoid arthritis. Rheumatology Meeting, 21 March, Sydney. LassereMN, Johnson KR, Sturgess A, Portek I, Edmonds J, Bird P, Carlton K. Marissa Lassere, Electronic Health Records: 14thAustralian Annual Health Congress Sydney. March. Cytokines, chemokines and vascular mediators of disease activity and damage in rheumatoid arthritis. Lassere MN, 2013- International Sturgess A, Baker S. Marissa Lassere, Biomarkers Update on Statistical Issues: Meta-analysis of image-guided versus blind corticosteroid National Cancer Institute: Bethesda, Maryland USA injection s in patients with arthritis. Johnson K, Lassere M, November. Tsai T, Buchbinder R. 2013 - National Original Peer-Reviewed Publications Marissa Lassere, Systematic review of surrogate endpoints: Lassere M.N, Rappo J., Portek I.J., Sturgess A., Edmonds University of NSW, Sydney, March. J.P. How many life years are lost in patients with rheumatoid arthritis? Secular cause-specific and all-cause Marissa Lassere, What’s new (or old) in the medical mortality in rheumatoid arthritis, and their predictors in management of osteoarthritis. St George Hospital Sydney a long-term Australian cohort study. Internal Medicine September. 51 CANCER SERVICES

Haematology > 53

Medical Oncology > 61

Palliative Care > 69

Radiation Oncology > 79 > Department of Haematology

Head of Department Research Grants

Professor Beng Chong, MBBS, PhD, FRCP, FRACP, FRCPA NHMRC Drug-induced immune thrombocytopenia BH Professor, Department of Medicine (Conjoint) UNSW Chong, M Davenport, $491,706 Jan 2011-Dec 2013. Director Clinical Haematology NHMRC Heparin-induced thrombocytopenia and Senior Medical thrombosis: Better understanding of pathogenesis and improving diagnosis and treatment. BH Chong, C Parish Professor Szu-Hee Lee, MBBChir, PhD, FRCPE, FRCPath, $631,010 Jan 2012-Dec 2014. FRACP, FRCPA, Senior Staff Specialist, Conjoint Professor UNSW NSW Cancer Institute of NSW X. Badoux, ALLG Project Manager $287,000 2013-2015. Staff Specialists Ho S, Cook C, Straube B, Fernandez R, et al. (2013-14). Dr Sundra Ramanathan, MBBS, FRACP, FRCPA The Action Study: Strategies to reduce the VRE infection Dr Fernando Roncolato, B Med FRACP FRCPA (Transmission and Bacteraemia) rates in high risk patients Dr Xavier Badoux, MBBS, FRACP, FRCPA admitted to 4E/4N wards. SESLHD infection prevention Dr Shir-jing Ho, MBBS, FRACP, FRCPA and control enhancement program $100,000. Dr Amanda Hugman, MBBS, FRACP, FRCPA Various Sponsor Companies as listed below in research Research Staff projects in progress - Principal investigators:. Professor Dr Christine Hicks. BSc, MSc, PhD. Conjoint lecturer Beng Chong, Dr Sundra Ramanathan, Dr Fernando UNSW Roncolato, Dr Xavier Badoux, Dr Shir-jing Ho, Dr Amanda Hugman, $ 530,000 2012 , $ 565,000 2013. Scientific Staff Unrestricted grant from GSK International I. ITP Registry: Sudha Pillai, Haematology Laboratory Manager A Multi-centre, prospective disease registry for adults Susan Smith Deputy Haematology Laboratory Manager diagnosed with primary immune thrombocytopenia purpura (ITP) Asia-Pacific, Middle Eastern and S American Senior Scientists countries 2011-2021, BH Chong ~$500,000 for 2012 2013. Rosalie Gemmell, Coagulation Laboratory Peter Loizou, Blood Bank Nella Mangos, Morphology: Christine Wassell. Bone Marrow Transplant Laboratory

Clinical Trials Unit

Roslyn Ristuccia BSc DipCompSc MMedSc(Epi), Manager Sarah Davidson RN Lorraine King RN Michael Szwajcer RN (CNS) Chris Sargent RN (CNS) Margaret Loizou BSc Elena Mendoza-Simon BSc Victoria Stevens BSc (Pharmacy) – Clinical Trials Pharmacist

53 Research Projects in Progress

Principal Short Title Trial - Title Investigator

ARES Anticoagulant Reversal and Events Study (ARES Collaborative) Amanda Hugman

Aspirin to prevent recurrent venous thromboembolism. A multi- centre, randomised, double-blind, placebo-controlled clinical trial ASPIRE Beng Hock Chong examining the efficacy and safety of low-dose aspirin after initial oral anticoagulation to prevent recurrent venous thromboembolism. Heparin-induced thrombocytopenia (HIT): Characterization of the CTBR-005 'HITS' pathogenic and non-pathogenic antibodies, and studies to improve Beng Hock Chong laboratory diagnosis and treatment. A Safety And Efficacy Trial Evaluating the use of Apixaban for the AMPLIFY EXTENSION Extended Treatment of Deep Vein Thrombosis and Pulmonary Beng Hock Chong Embolism A Safety and Efficacy Trial Evaluating the Use of Apixaban in the AMPLIFY TREATMENT Treatment of Symptomatic Deep Vein Thrombosis and Pulmonary Beng Hock Chong Embolism A Randomized, Double-blind, Placebo-controlled Study of the JAK Inhibitor INCB018424 Tablets Administered Orally to Subjects With COMFORT 1 Beng Hock Chong Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis or Post-Essential Thrombocythemia Myelofibrosis A Prospective, Phase IV, Open-Label, Multi-Center Study Evaluating Changes in Bone Marrow Morphology in Adult Subjects Receiving AMG 20080009 ITP BMT Beng Hock Chong Romiplostim for the Treatment of Thrombocytopenia Associated with Immune (Idiopathic) Thrombocytopenia Purpura (ITP) A Phase 3, Randomized, Double-Blind, Double-Dummy, Parallel- Group, Multi-Center, Multi-National Study for the Evaluation of The edoxaban HOKUSAI Efficacy and Safety of (LMW) Heparin/Edoxaban Versus (LMW) Beng Hock Chong VTE Study Heparin/Warfarin In Subjects with Symptomatic Deep-Vein Thrombosis and/or Pulmonary Embolism

The EINSTEIN VTE Oral direct factor Xa inhibitor rivaroxaban in patients with acute treatment study (St symptomatic deep-vein thrombosis or pulmonary embolism. The Beng Hock Chong George Private Hospital) Einstein VTE study

TT4-ITP01 Triple Therapy for Primary Immune Thrombocytopenia (ITP) Beng Hock Chong

A global, observational, non-interventional study collecting M07-001 PNH Registry effectiveness, safety and quality of life data on patients with Beng Hock Chong Paroxysmal Nocturnal Haemoglobinuria (PNH) Disease.

Amgen MM Observa- An Observational Study of Neutropenia in Subjects Being Treated Beng Hock Chong tional Study for Relapsed or Relapsed/Refractory Multiple Myeloma A Multi-centre, prospective disease registry for adults diagnosed ITP Registry with primary immune thrombocytopenia purpura (ITP) in Beng Hock Chong international countries. Two Weeks of Low Molecular Weight Heparin for Distal Vein TWISTER Beng Hock Chong Thrombosis (TWISTER)

Biomarkers of IVIG ef- Use of biomarkers as evidence based measurements of efficacy of ficacy during treatment Beng Hock Chong IVIG treatment of Immune Thrombocytopenia Purpura ITP of ITP 54 A Phase 3, Multicenter, Randomised, Double-Blind, Placebo- Controlled Parallel-group Trial with an open-label Extension Phase E5501 EISAI ITP to evaluate the Efficacy and Safety of Oral E5501 plus Standard of Beng Hock Chong care for the Treatment of Thrombocytopenia in Adults with Chronic Immune Thrombocytopenia (Idiopathic Thrombocytopenia purpura) An Open-Label, Multiple Simon 2-Stage Study of INCB039110 Administered Orally to Subjects With Primary Myelofibrosis (PMF), INCB 39110-230 Beng Hock Chong Post Polycythemia Vera-Myelofibrosis (PPV-MF) or Post Essential Thrombocythemia-Myelofibrosis (PET-MF) TRC 117146 is a randomised, single blinded, placebo-controlled, dose finding study to assess the PK interaction, safety and efficacy TRC117146 GSK AML of the oral thrombopoietin receptor agonist, eltrombopag, Beng Hock Chong administered to subjects with Acute Myelogenous Leukaemia (AML) receiving induction chemotherapy. A Randomized, Controlled, Double-Blind Phase III trial to Compare the Efficacy, Safety and Pharmacokinetics of GP2013 plus CVP ASSIST GP13-301 vs. MabThera plus CVP, Followed by GP2013 or MabThera Fernando Roncolato Maintenance Therapy in Patients with Previously Untreated, Advanced Stage Follicular Lymphoma

LEAF The Lymphoma Lifestyle, Environment And Family Study Fernando Roncolato

AMP Leukaemia and Lymphoma Tissue Bank A joint research ALLG Tissue Bank Shir-jing Ho initiative of ALLG and the Leukaemia Foundation A Phase II study in adult patients with newly diagnosed chronic- phase chronic myeloid leukaemia of initial intensified imatinib ALLG TIDEL II CML9 therapy and sequential dose-escalation followed by treatment Shir-jing Ho with nilotinib in suboptimal responders to determine the rate and duration of major molecular response A Phase I/II trial to determine safety & efficacy of combination ALLG MDS3 therapy with 5-azacitidine (Vidaza) and Thalidomide in patients with Shir-jing Ho Myelodysplastic Syndromes (MDS) Early Treatment Intensification With R-ICE Chemotherapy and Autologous Stem Cell Transplantation for Patients with Poor ALLG NHL21 Prognosis Diffuse Large B-Cell Lymphoma as Identified by Shir-jing Ho Interim PET/CT Scan Performed After Four Cycles of R-CHOP-14 Chemotherapy An Australasian, phase II, multicentre, randomised, dose intensification study investigating oral fludarabine, oral ALLG CLL5 OFOCIR cyclophosphamide and i.v. rituximab (poFCivR) tolerance in Shir-jing Ho previously untreated elderly (= 65 years old) patients with chronic lymphocytic leukaemia A randomised Phase II study comparing the efficacy of 5azacitidine alone versus combination therapy with lenalidomide and MDS4 Shir-jing Ho 5azacitidine in patients with higher risk myelodysplastic syndromes (MDS) and low marrow blast count acute myeloid leukaemia (AML) Response Post Tyrosine Kinase Inhibitor: Assessment of Sensitivity ALLG CML10 RESIST and Therapeutic Response to Next-Line Therapy in CML: The Shir-jing Ho Australasian RESIST study

55 A Randomised Controlled Trial to Compare Administration of Prothrombin Complex Concentrate with Standard Haemostasis Peritonectomy-PCC Shir-jing Ho Management In Adult Patients Undergoing Peritoneal Cytoreductive Surgery Requiring Massive Transfusion. Patterns and Experiences of Care in Adolescents and Young Adults AYA Pattern of Care Shir-jing Ho with Cancer A Randomized, Open-label, Phase 3 Study of Carfilzomib Plus ENDEAVOR MM Dexamethasone vs Bortezomib Plus Dexamethasone in Patients Shir-jing Ho with Relapsed Multiple Myeloma Protocol Number 2011-003 Strategies to reduce vre infection (transmission and bacteraemia) The ACTION study Shir-jing Ho rates in high risk patients admitted to 4E/4N wards. A two-stage phase 1b study to investigate the pharmacokinetics BP22333 Stage 1 in patients with follicular lymphoma (FL) as part of maintenance Sundra Ramanathan treatment A two-stage phase 1b study to investigate the pharmacokinetics BP22333 Stage 2 in patients with follicular lymphoma (FL) as part of maintenance Sundra Ramanathan treatment An open-label, multi-center, three arm randomized, phase III study to compare the efficacy and safety of RO5072759+chlorambucil CLL 11 BO21004 Sundra Ramanathan (GClb), rituximab + Chlorambucil (RClb) or chlorambucil (Clb) alone in previously untreated CLL patients with comorbidities. A phase 3, Multicentre, Randomized, Controlled study to determine the efficacy and safety of Cyclophosphamide, Lenalidomide and ALLG MM11 Sundra Ramanathan Dexamethasone (CRD) versus Melphalan (200mg/m2) followed by stem cell transplant in newly diagnosed multiple Myeloma subjects. An open-label, multi-centre,randomised, phase Ib study to investigate the safety and efficacy of RO5072759 given in GAUDI BO21000 Sundra Ramanathan combination with CHOP, FC or Bendamustine chemotherapy in patients with CD20+ B-cell follicular non-Hodgkin's lymphoma. Double blind randomized phase iii study of lenalidomide (revlimid®)maintenance vs. Placebo in responding elderly patients REMARC NHL25 Sundra Ramanathan with diffuse large b cell lymphoma and treated with r-chop in first line A Randomized Phase 4 study Comparing Intravenous Temsirolimus B1771007 Mantle Cell (TEMSR) Regimens in Subjects with Relapsed, Refractory Mantle Sundra Ramanathan Lymphoma Cell Lymphoma Extending molecular responses with Nilotinib in newly diagnosed ENESTxtnd: chronic myeloid leukemia (CML) patients in chronic phase Sundra Ramanathan CAMN107E2401 (ENESTxtnd)

Psychosocial Outcomes Improving Psychological Outcomes for Haematological Cancer Sundra Ramanathan An RCT patients: An RCT

Aplastic Anaemia Reg- Aplastic Anaemia Registry (AA) Sundra Ramanathan istry EvaluatiNg outcomes of newly-DiagnOsed AML patients at St ENDORSE Sundra Ramanathan GeoRge Hospital, SydnEy, Australia. Sorafenib in combination with intensive chemotherapy for ALLG AML M16 previously untreated adult FLT3-ITD positive AML: a phase 2 Sundra Ramanathan randomised double-blind placebo controlled multi-centre study Australasian Leukaemia and Lymphoma Group Common Acute ALLG AML M18 Registry Sundra Ramanathan Myeloid Leukaemia Registry

56 High dose melphalan: A pilot study to evaluate pharmacokinetic- High Dose Melphalan Sundra Ramanathan based dose determination in patients with multiple myeloma. A prospective randomised Phase II study of single agent pomalidomide maintenance versus combination pomalidomide and low dose dexamethasone maintenance following induction with ALLG MM14 Sundra Ramanathan the combination of pomalidomide and low dose dexamethasone in patients with relapsed and refractory myeloma previously treated with lenalidomide A randomized phase III study to compare Bortezomib, Melphalan, Prednisone (VMP) with High Dose Melphalan followed by ALLG MM15 Bortezomib, Lenalidomide, Dexamethasone (VRD) consolidation Sundra Ramanathan and Lenalidomide maintenance in patients with newly diagnosed multiple myeloma An Adaptive, comparative, randomised, parallel-group, multi- center, Phase 1b study of subcutaneous (SC) rituximab versus SAWYER BO25341 intravenous (IV) rituximab both in combination with chemotherapy Xavier Badoux (flurarabine and cyclophoshamide), in patients with previously untreated CLL A Randomized Phase II, Open-Label study of the Efficacy and Safety of Orally Administered SAR302503 in patients with polycythemia ARD12042 Xavier Badoux vera (PV) or essential thrombocythemia (ET) who are resistant or intolerant to hydroxyurea An Adaptive, comparative, randomised, parallel-group, multi- center, Phase 1b study of subcutaneous (SC) rituximab versus SAWYER BO25341 intravenous (IV) rituximab both in combination with chemotherapy Xavier Badoux (Part 2) (flurarabine and cyclophoshamide), in patients with previously untreated CLL A Phase 3, Multicenter, Randomized, Doubleblind, Placebo- Controlled, Parallel-Group Study Of The Efficacy And Safety Of Continuum Lenalidomide (Revlimid®) As Maintenance Therapy For Patients Xavier Badoux With B-Cell Chronic Lymphocytic Leukemia Following Second Line Therapy A Phase 3, Randomized, Controlled Study Evaluating the Efficacy Gilead CLL GS- and Safety of GS-1101 (CAL-101) in Combination with Ofatumumab Xavier Badoux US-312-0119 for Previously Treated Chronic Lymphocytic Leukemia A Randomized, Multicenter, Open-label, Phase 3 Study of the RESONATE PCYC-1115- Brutons Tyrosine Kinase Inhibitor PCI-32765 versus Chlorambucil Xavier Badoux CA in Patients 65 Years or Older with Treatment naive Chronic Lymphocytic Leukemia or Small Lymphocytic Lymphoma An Open-label Extension Study in Patients 65 Years or Older RESONATE 1116 Ext > with Chronic Lymphocytic Leukemia (CLL) or Small Lymphocytic Xavier Badoux 65yo Lymphoma (SLL) Who Participated in Study PCYC-1115-CA (PCI- 32765 versus Chlorambucil)

57 Original Peer-Reviewed Publications Chong BH. Drug-induced thrombocytopenia: MIBS trumps LIBS. Blood. 2012; 119 (26): 6177-8. PMID: 22745292. 2012 Zini G, d’Onofrio G, Briggs C, Erber W, Lee SH, NcFadden Badoux X, Keating M, Wen, S, Wierda W, O’Brien S, Faderl S, Yutaka N, Jou JM, Vives-Corrons JL, Lesesve JF. ICSH S, Sargent R, Burger J, Ferrajoli A (2013; Epub 2012 Dec recommendations for identification and quantification of 26). Phase II Study of Lenalidomide and Rituximab As schistocytes. Int J Lab Hematol. 2012. 34(2): 107-116. Salvage Therapy for Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia. Journal of Clinical 2013 Oncology, 31(5):584-91. Lee SH, van der Weyden C, Mayson E, Desai S. Excessive Hicks, C, Trickett, A, Kwan, YL, Ramanathan, S. The EDTA induces morphologic changes in bone marrow use of adjusted ideal body weight for overweight smears that mimic specific features of dysplasia. Int J Lab patients undergoing HPC mobilisation for autologous Hematol. 2013 Apr;35(2):163-9. transplantation. Annals of Hematology. 2012, Volume 91, Porter JB, Elalfy MS, Taher AT, Aydinok Y, Chan LL, , Issue 11, pp 1795-1801. Lee SH Sutcharitchan P, Habr D, Martin N, El-Beshlawy A. Efficacy Choi P, Gordon J, Harvey M, Chong B. Report on the and safety of deferasirox at low and high iron burdens: Presentation and Outcome of ITP in Single Australian results from the EPIC magnetic resonance imaging Centre. Intern Med J. 2012; 42(7):841-5. PMID:22805691. substudy. Ann Hematol. 2013 Jan;92(2):211-9.

Khachigian LM, Cai H, Moloney FJ, Parish CR, Chong BH, Braidy N, Gai WP, Xu YH, Sachdev P, Guillemin GJ, Jiang Stocker R, Barnetson RS, Halliday GM. Destroying c-Jun XM, Ballard JW, Horan MP, Fang ZM, Chong BH, Chan Messenger: New Insights into Biological Mechanisms of DK. Uptake and mitochondrial dysfunction of alpha- DNAzyme Function. Oncotarget. 2012; 3(6):594-5. PMID: synuclein in human astrocytes, cortical neurons and 22805148. fibroblasts. Transl Neurodegener. 2013; 2(1): 20.

Sanchez-Guerrero E, Chen E, Kockx M, An SW, Chong BH, Perdomo J, Yan F, Chong BH. A megakaryocyte with no Khachigian LM. IL-1beta Signals through the EGF Receptor platelets: anti-platelet antibodies, apoptosis and platelet and Activates Egr-1 through MMP-ADAM. PLoS One. production. Platelets.2013;24(2):98-106. 2012; 7(7):e39811. Epub 2012 Jul 6. PMID: 22792188. Chong BH, Chong JJ. HIT: nucleic acid masquerading as Caii H, Santiago FS, Prado-Lourenco L, Wang B, Patrikakis heparin. Blood. 2013; 122(2): 156-158. M, Davenport MP, Maghzal GI Stocker R, Parish CR, Chong Chong BH, Choi PY, Khachigian L, Perdomo J. Drug- BH, Lieschke GJ, Wong TW, Chesterman CN, Francis . DJ, induced immune thrombocytopenia. Hematol Oncol Clin Moloney FJ, Barnetson RS, Halliday GM, Khachigian LM. North Am. 2013; 27(3):521-40. DNAzyme Targeting c-jun Suppresses Skin Cancer Growth. Sci Transl Med. 2012; 4(139):139-82. PMID: 22723462. Coupland LA, Chong BH, Parish CR. Beware of NK Cells in Pre-clinical metastasis models. Clin Exp Metastasis. 2013; Coupland LA, Beng H. Chong, Christopher R. Parish. 30(7):945-7 Platelets and P-selectin control tumor metastasis in an organ-specific manner and independently of NK cells. Sanchez-Guerrero E, Jo SR, Chong BH, Khachigian LM. Cancer Research. Published Online July 26, 2012; doi: EFGR and the complexity of receptor crosstalk in the 10.1158/0008-5472.CAN-11-4010 cardiovascular system Curr Mol Med. 2013; 13(1): 3-12. Review. Gao RL, Chong BH. Research and development of the effective components of panaxdiol saponin as new Tsimberidou AM, Wierda WG, Wen S, Badoux XC, et al. Chinese patent medicine for treating hemocytopenia. Chin Phase I-II clinical trial of oxaliplatin, fludarabine, cytarabine, J Integr Med. 2012; 18(12): 897-902. and rituximab therapy in aggressive relapsed/refractory chronic lymphocytic leukemia or Richter syndrome. Clin Perdomo J, Jiang XM, Carter DR, Khachigian LM, Chong Lymphoma Myeloma Leuk. 2013;13(5):568-74. BH. SUMOylation regulates the transcriptional repression activity of FOG-2 and its association with GATA-4. PLoS Strati P, Keating MJ, Wierda WG, Badoux XC et al. One. 2012;7(11):e50637. Lenalidomide induces long-lasting responses in elderly patients with chronic lymphocytic leukemia. Blood. Perdomo J, Yan F, Chong BH. A megakaryocyte with 2013;122(5):734-7. no platelets: anti-platelet antibodies, apoptosis and platelet production. Platelets. 2013; 24(2):98-106. PMID: Badoux XC, Keating MJ, Wen S, et al. Phase II study of 22742725. lenalidomide and rituximab as salvage therapy for patients

58 with relapsed or refractory chronic lymphocytic leukemia. National Blood Centre, Haematology seminar. “Making J Clin Oncol. 2013;31(5):584-91. platelets in a flask” Kuala Lumpur, Malaysia

Other Published Material The International Society on Thrombosis and Haemostasis, Liverpool, United Kingdom, June 27-30, 2012. 58th Annual Hsu D, Lee SH. Digital Imaging in Hematology. In SSC Meeting, Platelet Immunology Subcommittee: Laboratory Hematology Practice. Eds Marchant KM, Davis “Drug-induced immune thrombobocytopena: Animal B. Wiley-Blackwell. 2012. pp707-718 Model”; “ Effects of drug-induced antibody on megakaryocytes.” Greinacher A, Warkentin TE, Chong, BH. Heparin-induced Thrombocytopenia, In Platlelets (3rd Edition) Ed Michelson Invited speaker by Hong Kong Association of Blood AD, Academic Press New York. 2012. Transfusion and Haematology and by Queen Mary Hospital, HK: 26 -30 november 2012. Titles: (1) ITP: Chong BH, van der Weyden, Carrie. Deep vein thrombosis pathogenesis & treatment; (2) Heparin-induced and pulmonary embolism, in: Disease Index (Fifth Edition) thrombocytopenia; (3). Molecular regulation of Ed: Worth O, MIMS Australia, 2012 . thrombopoiesis; (4) Anti-platelet therapy: basics & recent Chong BH, Magnani HN. Danaparoid in the treatment of advances. heparin-induced throbocytopenia, in: Heparin-induced Prof Szu-Hee Lee Thrombocytopenia, Eds: Warkentin T, Greinacher A. 5th Edition. Marcel Dekker, New York 2012. Invited Speaker, “Optimizing the Quality of Bone Marrow Specimens and Reports”, International Society for Presentations at Scientific Meetings and Laboratory Hematology 2012, Nice, France, May 2012. Conferences Int.J.Lab.Hematol. 2012, 34 (Suppl. 1): 32-33). 2012 - International 2012 - National Professor Beng Hock Chong Prof Beng Hock Chong ITP lecture series April 5-9, 2012.Apollo Hospital Group, Invited Speaker: ITP symposium Haematology Further Chennai, India. 2012 April 5. “ITP Update.” Education Activity, ITP in Australia Perth Feb 17 and Chhatrapati Shahuji Maharaj Medical University (formerly Melbourne Feb 20. King George Medical) Locknow, India, 21012 April 6. Invited Speaker : Pathology Update, Royal College of “Management of ITP: New agents. “ Pathologists of Australasia, Sydney March 9-11,2012 National Haematology Update IX conference, 2012, “Drug-induced immune thrombocytopenia: Pathogenesis, organized by the All India Institute of Medical Sciences, diagnosis and treatment.” New Delhi, April 7. “Management of ITP: International 2013 - International Guidelines – Consensus and Differences. “ Prof Beng Hock Chong Tata Medical Centre and University, Kolkata, India. 21012, Taiwan Haematology Society Annual Meeting, Taipei, 13th April 9. “HIT and HITT. “Diagnosis and Management of -14th April, 2013: “Clinical decision making in ITP: When ITP.” to treat and how to treat.” Royal College of Pathologists of Australasia South-east 10th Malaysian Society of Haematology Scientific Asia Lecture series June 5-12, 2012. Meeting 26 to 28th April 2013, Penang Malaysia. “Megakaryocytopoiesis and Haemostasis in Normal Chapter of Haematologists, College of Physicians, “How subject”; “The therapeutic use of thrombopoietic agents I treat ITP patients including the pregnant patient.” and clot promoting factors” Singapore Hicks C., Goodman N., Gemmell R., Roncolato F., Academy of Medicine, College of Pathologists, Annual Ramanathan S. Platelet harvest, cryopreservation and Meeting 2012 (Keynote Address) K Pratap Memorial infusion; Re-expanding the resources of the BMT lab. Lecture.” New Dawn In Laboratory Medicine.” Malaysia Exp Hem 41(8) S1. Abstract. International Society for Experimental Haematology ISEH. Vienna 2013 University Putra Malaysia Haematology seminar. “Updates on laboratory tests for immune platelet disorders”,

“Platelet function abnormalities in Myeloproliferative

Neoplasm and their laboratory testing.” Malaysia

59 2013 - National

Gemmell R, Cavanaugh L, Hicks C, Roncolato F, Chong, B. Platelet Function Testing of cryopreserved platelets. Abstract. HAA Haematology Society of Australia and New Zealand, the Australian & New Zealand Society of Blood Transfusion and the Australasian Society of Thrombosis and Haemostasis, Broadbeach, Queensland, 20-23 October.

Chong, BH. Carl de Gruchy Memorial Lecture, Title: Platelet: Small Cell Big Impact, St Vincent Hospital, Melbourne. 16 September.

Community Engagement

Professor Beng Chong

Member of the Board of St George Medical Research Foundation and Deputy Chair, Scientific Advisory Committee, St George Medical Research Foundation. Member, Medical and Dental Appointments Committee, St George Hospital, Sydney Member of Clinical Council, St George Hospital, Sydney Council member, Asia-Pacific Society of Thrombosis and Haemostasis Vice-President, Australian Bid Committee, International Society of Thrombosis and Haemostasis

Prof Szu-Hee Lee

Chair of the Science and Education Committee of the International Society of Haematology, Asia-Pacific Division (ISHAPD) since 1997 Vice-President of the International Council for Standardization in Hematology (ICSH) since 2009 Co-Chief Editor of the International Journal of Laboratory Hematology since 2010 Member, Editorial Board, Pathology Member, International Advisory Panel, Malaysian Journal of Pathology Vice-Chair, International Council for Standardization in Haematology.

60 > Department of Medical Oncology

Head of Department Research Grants

Dr Kiran Phadke MB CHB FRACPA FRACP NSW Cancer Institute Associate Professor Winston Liauw Senior Medical Cancer Clinical Trials Staff Grant Dr Patricia Bastick MB BS BMedSc FRACP Grad Cert $262,581 2012-2014. Epidemiology, Conjoint Associate Lecturer UNSW Cancer Australia Dr Chee Lee MB BS MMEDSC (Clinical Epidemiology) L.Mileshkin, M.Quinn, P.Khaw, C.Creutzberg, M.Stockler, FRACP MBiostats PhD A. Brand, J. Martyn, K. Sjoquist Associate Professor Winston Liauw, MB BS MMedSC Randomised Phase III Trial Comparing Concurrent FRACP GAICD Grad Cert Politics and Policy Chemo- radiation and Adjuvant Chemotherapy with Conjoint Associate Professor Matthew Links, MB BS Pelvic Radiation Alone in High Risk and Advanced Stage FRACP PhD Endometrial Carcinoma: PORTEC-3 Dr Jodi Lynch, MB BS FRACP $300,878 2012-2014. Dr Katrin Sjoquist, MB BS BSc Med FRACP MClinT Dr David Thomas, MB BS FRACP University of Sydney Cancer Research Fund Grant (CRFG). M.Friedlander, K Sjoquist Research Staff Intraperitoneal Bevacizumab Therapy in Malignant Ascites, Peter Fink BSc – Manager, Clinical Trials Unit $50,000 2011-2012.

Clinical Trials Coordinators Ovarian Cancer Research Foundation (OCRF) D Robertson, H Burger, M Friedlander, K Sjoquist, J Antoinette Fontela BSc Martyn. The role of Inhibin as a biomarker of response in Mary Margaret Gozar PhD Granulosa Cell Tumours Stephen Millard CNS $20,000 2012-2014. Indira Mismit RN Shu Pan BSc Cancer Australia Project Grant 626201 Penelope Taylor CNS Principal investigators A/Prof P Graham, Prof G Delaney, Lisa Wang MSc Dr E Millar, Dr Anne Capp, Als Prof R Sutherland, Dr S Victoria Stevens BPharm – Clinical Trials Pharmacist Carroll, Dr J Harvey, Dr J Lynch, Dr R Tse. Trans Tasman Radiation Oncology Group 08.06: A Randomised comparison of anastrozole commenced before and continued during adjuvant radiotherapy for breast cancer versus anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy. (STARS – Study of Anastrozole and Radiotherapy Sequencing). $660,000 2010-2012.

61 Research Projects in Progress

Principal Short Name Title Investigator Study VEG108844, a Study of Pazopanib Versus Sunitinib in the COMPARZ Treatment of Subjects With Locally Advanced and/or Metastatic Winston Liauw Renal Cell Carcinoma A Multicenter Phase III Randomized Trial of Adjuvant Therapy for Patients With HER2-Positive Node-Positive or High Risk BETH Node-Negative Breast Cancer Comparing Chemotherapy Jodi Lynch Plus Trastuzumab With Chemotherapy Plus Trastuzumab Plus Bevacizumab Randomized phase III trial comparing doxorubicin and cyclophosphamide followed by docetaxel (AC->T) with doxorubicin and cyclophosphamide followed by docetaxel and BCIRG 006 trastuzumab (AC->TH) and with docetaxel, platinum salt and Matthew Links trastuzumab (TCH) in the adjuvant treatment of node positive and high risk node negative patients with operable breast cancer containing the HER2neu alteration. CARBO/TAX: Wkly Carboplatin + Taxol and Concomitant RT for Carbo/Tax Matthew Links locally advanced NSCLC: Predictors of Rx Tolerance. A phase III trial evaluating the role of ovarian function SOFT suppression and the role of exemestane as adjuvant therapies for Jodi Lynch premenopausal women with endocrine responsive breast cancer. Randomized phase III trial comparing docetaxel in combination with doxorubicin and cyclophosphamide (TAC) versus doxorubicin BCIRG 005 and cyclophosphamide followed by docetaxel (AC->T) as adjuvant Matthew Links treatment of operable breast cancer HER2neu negative patients with positive axillary lymph nodes Phase III randomised, multi-centre, international trial to determine the relation between dose and clinical activity of STI-571 in AG0102 GIST patients with unresectable or metastatic malignant gastrointestinal Matthew Links stromal tumors expressing the c-kit receptor tyrosine kinase (CD117). A phase III randomised study of Brivanib (BMS-582664) in combination with Cetuximab (Erbitux½) versus Placebo in CO.20 combination with Cetuximab (Erbitux½) in patient previously Winston Liauw treated with combination chemotherapy for metastatic colorectal carcinoma A Phase 1 study of RAD001 (everolimus) in combination with RAD001 Matthew Links fluvastin and zoledronic acid in patients with solid tumours A Randomized, Double-Blind, Multicenter, Placebo-Controlled TEACH Study of Adjuvant Lapatinib (GW572016) in Women With Early- Jodi Lynch Stage ErbB2 Overexpressing Breast Cancer Phase II, multi-center, two-stage study utilising a randomised discontinuation design to evaluate the safety and efficacy of VEG102616 Winston Liauw GW786034 in adult subjects with locally recurrent or metastatic clear-cell Renal Cell Carcinoma (RCC).

62 A Randomized, Multicenter, Open-Label Phase 3 Study of Pemetrexed-Cisplatin Chemotherapy Plus IMC-11F8 Versus Inspire Pemetrexed-Cisplatin Chemotherapy Alone in the First-Line Matthew Links Treatment of Patients With Nonsquamous Stage IIIb or IV Non- Small Cell Lung Cancer (NSCLC) A Randomized, Multicenter, Open-Label, Phase 3 Study of Gemcitabine-Cisplatin Chemotherapy Plus Necitumumab (IMC- Squire 11F8) Versus Gemcitabine-Cisplatin Chemotherapy Alone in the Matthew Links First- Line Treatment of Patients With Stage IV Squamous Non- Small Cell Lung Cancer (NSCLC) A Randomized, Double-Blind, Placebo-Controlled, Multi-Center Phase 3 Study of Denosumab as Adjuvant Treatment for Women D-Care Jodi Lynch with Early-Stage Breast Cancer at High Risk of Recurrence (D-CARE) Prediction of cardiotoxicity by measurement of serum N-terminal CATS pro-B-type natriuretic peptide in breast cancer patients receiving Jodi Lynch adjuvant trastuzumab Multicenter Phase III Randomized Trial Comparing Doxorubicin And Cyclophosphamide Followed By Docetaxel (AC®T) With Doxorubicin And Cyclophosphamide Followed By Docetaxel And Trastuzumab (Herceptin®) (AC®TH) And With Docetaxel, BCIRG 006 Sub study Matthew Links Carboplatin And Trastuzumab (TCH) In The Adjuvant Treatment Of Node Positive And High Risk Node Negative Patients With Operable Breast Cancer Containing The Her2 Alteration. Breast Cancer Recurrence Substudy Randomized, Double-Blind, Phase 3 Trial to Compare the Efficacy of Ipilimumab vs Placebo in Asymptomatic or Minimally CA184095 Patricia Bastick Symptomatic Patients with Metastatic Chemotherapy-Naïve Castration Resistant Prostate Cancer A Randomized, Multicenter, Double-Blind, Placebo-Controlled Phase 3 Study of Weekly Paclitaxel With or Without Ramucirumab Rainbow (IMC-1121B) Drug Product in Patients With Metastatic Gastric Winston Liauw Adenocarcinoma, Refractory to or Progressive After First-Line Therapy With Platinum and Fluoropyrimidine A Double Blind Placebo Controlled Randomized Trial Of PF-804 In Patients with Incurable Stage IIIb/IV Non-Small Cell Lung Cancer BR.26 Matthew Links After Failure Of Standard Therapy For Advanced Or Metastatic Disease The Utility Of Genomics And Functional Imaging To Predict Predict IR Irinotecan Pharmacokinetics And Pharmacodynamics: The Predict Winston Liauw IR Study A Phase 3, Randomized, Double-Blinded, Placebo-Controlled Study Of ARQ 197 Plus Erlotinib Versus Placebo Plus Erlotinib In Marquee Matthew Links Previously Treated Subjects With Locally Advanced Or Metastatic, Non-Squamous, Non–Smallcell Lung Cancer (NSCLC) A randomized Phase III, double-blind, placebo-controlled multicenter trial of daily everolimus in combination with Bolero 3 Patricia Bastick trastuzumab and vinorelbine, in pretreated women with HER2/neu over-expressing locally advanced or metastatic breast cancer

63 A Phase 3, multicenter, randomized, double-blind, placebo controlled trial of AMG 479 or placebo in combination with Gamma Winston Liauw Gemcitabine as first-line therapy for metastatic adenocarcinoma of the pancreas A Multi-Centre Study of Tamoxifen Dose Escalation Study in Breast TADE Jodi Lynch Cancer Patients with CYP2D6 Polymorphisms A Phase III Randomized, Multicenter, Two-Arm, Open-Label Trial to Evaluate the Efficacy of Trastuzumab Emtansine Compared With Th3resa Treatment of Physician's Choice in Patients With HER2 Positive Patricia Bastick Metastatic Breast Cancer Who Have Received at Least Two Prior Regimens of HER2 Directed Therapy A Trial in the Timing of Surgery and Adjuvant Chemotherapy for Hepatic Metastases from Colorectal Cancer. A phase III, multi-cen- Attache tre, randomised trial comparing perioperative morbidity between Winston Liauw those given chemotherapy prior to and post surgical resection versus those given chemotherapy post surgical resection. A Phase II, Double-Blind, Placebo Controlled, Randomized Study of GDC-0941 or GDC-0980 With Fulvestrant Versus Fulvestrant Fergi Jodi Lynch in Advanced or Metastatic Breast Cancer in Patients Resistant to Aromatase Inhibitor Therapy A Phase III Prospective, Two-Cohort Non-Randomized, Multi- Centre, Multinational, Open Label Study To Assess The Safety Of SafeHer Assisted- And Self-Administered Subcutaneous Trastuzumab As Patricia Bastick Adjuvant Therapy In Patients With Operable Her2-Positive Early Breast Cancer Randomized, Multicenter, Double-Blind, Phase 3 Trial Comparing the Efficacy of Ipilimumab Plus Etoposide/Platinum Versus IDEate Chee Lee Etoposide/Platinum in Subjects With Newly Diagnosed Extensive- Stage Disease Small Cell Lung Cancer (ED-SCLC) A Phase 2, Open Label, Multicenter, Randomized Trial Comparing Tivozanib in Combination With mFOLFOX6 to Bevacizumab in Baton Winston Liauw Combination With mFOLFOX6, In Stage IV Metastatic Colorectal Cancer (mCRC) Subjects A Randomised, Open-label Phase IIb Trial of Afatinib Versus Lux Lung-7 Gefitinib as First-line Treatment of Patients With EGFR Mutation Chee Lee Positive Advanced Adenocarcinoma of the Lung A controlled trial of an optimized multidisciplinary intervention for TOPS Trial Patricia Bastick post-cancer fatigue A randomised phase II double-blind study to evaluate the effect of Regorafenib or placebo on progression-free survival and objective Integrate Katrin Sjoquist response rate in refractory advanced oesophago-gastric cancer (AOGC) A Randomized Phase 3 Study Comparing Cabazitaxel/Prednisone in Combination With Custirsen (OGX-011) to Cabazitaxel/ Affinity Patricia Bastick Prednisone for Second-Line Chemotherapy in Men With Metastatic Castrate Resistant Prostate Cancer. Phase II study investigating the ability of Macrophage Inhibitory Cytokine-1 (MIC-1) and associated plasma markers to predict Mic-1 Patricia Bastick response to chemotherapy in men with metastatic castrate- resistant prostate cancer

64 A Phase II, Multicenter, Open-Label, Randomized Study Evaluating the Efficacy and Safety of MEHD7945A + FOLFIRI Versus Dareck Winston Liauw Cetuximab + FOLFIRI in Second Line in Patients With KRAS Wildtype Metastatic Colorectal Cancer A Randomized, Double-Blind, Phase 2, Dose-Ranging Study to Evaluate the Safety and Efficacy of Veliparib and Whole Brain M10-897 Radiation Therapy Versus Placebo and Whole Brain Radiation Matthew Links Therapy in Subjects With Brain Metastases From Non-Small Cell Lung Cancer. Randomized phase II study of BEZ235 or everolimus in advanced BEZ235 Winston Liauw pancreatic neuroendocrine tumours. A Multinational, Randomized, Open-Label Phase III Study of Custirsen (TV-1011/OGX-011) In Combination With Docetaxel Enspirit Chee Lee Versus Docetaxel As A Second-Line Treatment In Patients With Advanced or Metastatic (Stage IV) Non-Small Cell Lung Cancer A phase IIIb, multi-center, open-label, expanded access study of EVERolimus (RAD001) in combination with EXemestane in post- Everexes menopausal women with EStrogen receptor positive, human Patricia Bastick epidermal growth factor receptor 2 negative locally advanced or metastatic breast cancer EVEREXES A randomised phase II study evaluating the potential molecular profile of biliary tract cancer and also examining the clinical benefit TACTIC Winston Liauw and safety of panitumumab, cisplatin and gemcitabine in the treatment of biliary tract cancer. A Phase III Study of the Impact of a Physical Activity Program on CHALLENGE Disease-Free Survival in Patients With High Risk Stage II or Stage Winston Liauw III Colon Cancer: A Randomized Controlled Trial A Phase 1b/2 Trial of AMG 386 in Combination With Pemetrexed AMG386 and Carboplatin as First Line Treatment of Metastatic Non- Matthew Links Squamous Non-Small Cell Lung Cancer A Phase Iii Randomized Study of Bbi608 and Best Supportive CO23 Care versus Placebo and Best Supportive Care In Patients with Winston Liauw Pretreated Advanced Colorectal Carcinoma Safety, Tolerability, Pharmacokinetics & Antitumour Activity of AZD9291 in Patients With Advanced Non Small Cell Lung Cancer Aura Chee Lee Who Have Progressed on Prior Therapy With an Epidermal Growth Factor ReceptorTyrosine Kinase Inhibator Agent

65 Original Peer-Reviewed Publications Dimoska, A., Butow, P. N., Lynch, J., Hovey, E., Agar, M., Beale, P., & Tattersall, M. H. N. (2012). Implementing 2012 patient question-prompt lists into routine cancer care. [doi: 10.1016/j.pec.2011.04.020]. Patient Education and Chua, T., Al-Alem, I., Zhao, J., Glenn, D., Liauw, W., & Counseling, 86(2), 252-258. Morris, D. (2012). Radiofrequency Ablation of Concomitant and Recurrent Pulmonary Metastases after Surgery for C.K. Lee, C. Brown, R. Gralla, V. Hirsh, A. Inoue, V. Colorectal Liver Metastases. Annals of Surgical Oncology, Gebski, C.J. Yang. Impact Of Epidermal Growth Factor 19(1), 75-81. Receptor-Tyrosine Kinase Inhibitor Treatment In Advanced Non-Small Cell Lung Cancer: A Meta-Analysis. Annals of Chua, T., Liauw, W., & Morris, D. (2012). Early recurrence Oncology 2012, 23 (suppl 9): ix400-ix446. of pseudomyxoma peritonei following treatment failure of cytoreductive surgery and perioperative intraperitoneal Chee Khoon Lee, Ian Marschner, R John Simes, Merryn chemotherapy is indicative of a poor survival outcome. Voysey, Brian Egleston, Gary Hudes, Paul de Souza. International Journal of Colorectal Disease, 27(3), 381-389. Increase in cholesterol predicts survival advantage in renal cell carcinoma patients treated with temsirolimus. Clinical Chua, T., Liauw, W., Zhao, J., & Morris, D. (2012). Cancer Research 2012, 18(11), 3188–3196. Comparative analysis of perioperative intraperitoneal chemotherapy regimen in appendiceal and colorectal C. K. Lee, R. J. Simes, C. Brown, V. Gebski, J Pfisterer, peritoneal carcinomatosis. International Journal of Clinical A-M. Swart, D. Berton-Rigaud, M. Plante, T. Skeie-Jensen, Oncology, Jun;18(3):439-46. I. Vergote, C. Schauer, C. Pisano, G. Parma, K. Baumann, J. A. Ledermann, E. Pujade-Lauraine, J. Bentley, G. Chua, T. C., Chong, C. H., Liauw, W., & Morris, D. L. Kristensen, A. Belau, M. Nankivell, U. Canzler, S. J. Lord, (2012). Approach to Rectal Cancer Surgery. International C. Kurzeder, M. Friedlander. A prognostic nomogram to Journal of Surgical Oncology, 2012 2012. Published on predict overall survival in patients with platinum-sensitive line June 27 2012: Article ID 247107. recurrent ovarian cancer. Annals of Oncology 2012. 2013 Chua, T. C., Chong, C. H., Liauw, W., Zhao, J., & Apr;24(4):937-43. Morris, D. L. (2012). Inflammatory Markers in Blood and Links, M., Sargeant, C., Waters, A., Liauw, W., & Thomas, Serum Tumor Markers Predict Survival in Patients With P. (2012). Implementing a Multi-professional Web-based Epithelial Appendiceal Neoplasms Undergoing Surgical Learning Environment for a Comprehensive Cancer Cytoreduction and Intraperitoneal Chemotherapy. Annals Centre: Obstacles, Solutions and Reflections. Journal of of Surgery, 256(2), 342-349. Cancer Education, 27(1), 37-41. Chua, T. C., Liauw, W., Chu, F., & Morris, D. (2012). Verry H, Lord SJ, A Martin A, Gill G, Lee CK, Howard K, Viewing Metastatic Colorectal Cancer as a Curable Chronic Wetzig N, Simes J. Effectiveness and cost-effectiveness Disease. American Journal of Clinical Oncology, 35(1), of sentinel node biopsy compared with axillary node 77–80. dissection in patients with early stage breast cancer: a Chua, T. C., Liauw, W., Chu, F., & Morris, D. L. (2012). decision model analysis. British Journal of Cancer 2012, Summary outcomes of two-stage resection for advanced 106, 1045–1052. colorectal liver metastases. Journal of Surgical Oncology, Waller, A., Girgis, A., Johnson, C., Lecathelinais, C., 2013 Feb;107(2):211-6. Sibbritt, D., Forstner, D., Liauw, W., & Currow, D. C. (2012). Chua, T. C., Moran, B. J., Sugarbaker, P. H., Levine, E. A., Improving Outcomes for People With Progressive Cancer: Glehen, O., Gilly, F. N., Baratti, D., Deraco, M., Elias, D., Interrupted Time Series Trial of a Needs Assessment Sardi, A., Liauw, W., Yan, T. D., Barrios, P., Gómez Portilla, Intervention. Journal of Pain and Symptom Management, A., de Hingh, I. H. J. T., Ceelen, W. P., Pelz, J. O., Piso, P., 43(3), 569-581. González-Moreno, S., Van Der Speeten, K., & Morris, D. 2013 L. (2012). Early- and Long-Term Outcome Data of Patients With Pseudomyxoma Peritonei From Appendiceal Origin Lobb, E. A., J. Lacey, J. Kearsley, W. Liauw, L. White Treated by a Strategy of Cytoreductive Surgery and and A. Hosie (2013). Living with advanced cancer and Hyperthermic Intraperitoneal Chemotherapy. Journal of an uncertain disease trajectory: an emerging patient Clinical Oncology, 30(20), 2449-2456. population in palliative care? BMJ Supportive & Palliative Care. 2013 Jan 29. Chua, T. C., Saxena, A., Liauw, W., Chu, F., & Morris, D. L. (2012). Hepatectomy and resection of concomitant Sommeijer, D. W., K. M. Sjoquist and M. Friedlander extrahepatic disease for colorectal liver metastases – A (2013). Hormonal Treatment in Recurrent and Metastatic systematic review. [doi: 10.1016/j.ejca.2011.10.034]. Gynaecological Cancers: A Review of the Current European Journal of Cancer (0). 66 Literature. Current Oncology Reports: 2013 Dec;15(6):541- of Epidermal Growth Factor Receptor Tyrosine Kinase 8. Inhibitors (EGFR-TKIs) in the Treatment of Advanced Non- Small Cell Lung Cancer (NSCLC): A Meta-analysis. Journal Price TJ, Hardingham JE, Lee CK, Townsend AR, Wrin JW, of Thoracic Oncology 2013; 8, Supplement 2, S593, Wilson K, et al. Prognostic impact and the relevance of PTEN copy number alterations in patients with advanced Other Published Material colorectal cancer (CRC) receiving bevacizumab. Cancer Medicine 2013, doi: 10.1002/cam4.75. Chow, Hui Ting, Tran, Kim, Millar, Ewan K. A., Lynch, Jodi, Murrell, Dedee F. (2012). Diverse Presentations of Lee CK, Brown C, Gralla RJ, Hirsh V, Thongprasert S, Tsai Carcinoma Erysipelatoides from a Teaching Hospital in C-M, Tan EH, Ho JC-M, Chu DT, Zaatar A et al. Impact Australia. Case Rep Dermatol Med. 2012; 2012: 134938. of EGFR Inhibitor in Non–Small Cell Lung Cancer on Progression-Free and Overall Survival: A Meta-Analysis. Links, M., & Galettis, P. (2012). One Step Closer to the Journal of the National Cancer Institute 2013, 105(9):595- Target: Intracellular Pharmacokinetics of Gemcitabine (20 605. April, 2012 ed.): InTech, April, 2012.

You B, Colomban O, Heywood M, Lee C, Davy M, Reed N, Presentations at Scientific Meetings and Pignata S, Varsellona N, Emons G, Rehman K, Steffensen Conferences KD, Reinthaller A, Pujade-Lauraine E, Oza A. The strong 2012 International prognostic value of KELIM, a model-based parameter from CA 125 kinetics in ovarian cancer: Data from CALYPSO trial YJ Chua, C Karapetis, C Underhill, L M.Nott, D Goldstein, (a GINECO-GCIG study). Gynecologic Oncology 2013, M Cronk, V Gebski, N Wong, K M Sjoquist, A Biankin, doi:10.1016/j.ygyno.2013.05.013. Australasian Gastrointestinal Trials Group (AGITG) PAN1: A randomized phase II study evaluating potential predictive Peter Fox, Malcolm Hudson, Chris Brown, Sarah Lord, biomarkers in the treatment of metastatic pancreatic Val Gebski, Paul De Souza, Chee Khoon Lee. Markers of cancer. Poster, American Society of Clinical Oncology systemic inflammation predict survival in patients with (ASCO) Annual Meeting, Chicago, June 2012. advanced renal cell cancer. British Journal of Cancer 2013, 109, 147–153. J Fawcett, K M Sjoquist, R Padbury, C Christophi, N Tebbutt, C Pilgrim, VGebski, N Wong, CE Aiken, D Chee Khoon Lee, Val J Gebski, Alan S Coates, Anne- Goldstein, Australasian Gastro-Intestinal Trials Group Sophie Veillard, Vernon Harvey, Martin HN Tattersall, (AGITG) ATTACHE: A phase III, multicenter, randomized Michael J Byrne, Brian Brigham, John Forbes, R John comparison of chemotherapy given prior to and post- Simes and on behalf of Australia and New Zealand Breast surgical resection versus chemotherapy given post-surgical Cancer Trials Group (ANZBCTG). Trade-offs in quality resection for hepatic metastases from colorectal cancer. of life and survival with chemotherapy for advanced Poster, ASCO Annual Meeting, Chicago, June 2012. breast cancer: mature results of a randomized trial comparing single-agent mitoxantrone with combination Price TJ, Hardingham J, Lee C, Wrin J, Townsend A, cyclophosphamide, methotrexate, 5-fluorouracil and Wilson K, Weickhardt A, Simes J, Murone C, Tebbutt N. prednisone. SpringerPlus 2013, 2:391. Analysis of PTEN in patients with advanced colorectal cancer (CRC) receiving capecitabine alone or in Felicia Roncolato, Pei Ding, Sally Lord, Val Gebski, Chee combination with bevacizumab with or without mitomycin Khoon Lee. Risk of Treatment-related Mortality with C in the phase III AGITG MAX trial. Journal of Clinical Bevacizumab treatment in advanced cancers. European Oncology, ASCO Annual Meeting Proceedings, Chicago, Journal of Cancer 2013; 49, Supplement 2. June 2012; 30 (15 suppl): 3534. Pei Ni Ding, Richard Gralla, Akira Inoue, Sally Lord, Nick , Lord S, Chatfield M, Friedlander M, Pavlakis, Tetsuya Mitsudomi, Matthew Links, Val Gebski, Sjoquist KM, Lee C Simes J, Marschner I. Progression-free survival (PFS) as a James C. Yang, Chee Khoon Lee. Exon 19 deletions, surrogate end point for overall survival (OS) in first-line smoking history and gender as additional predictive treatment of advanced epithelial ovarian cancer (EOC). factors for treatment benefit with EGFR Tyrosine Kinase Journal of Clinical Oncology, ASCO Annual Meeting Inhibitors in patients harbouring activating EGFR Proceedings 2012; 30 (15 suppl): 5081. mutations: A Meta-analysis of 1432 patients in six randomised trials. Journal of Thoracic Oncology 2013; 8, K Sjoquist, C Lee, S Lord, M Chatfield, M Friedlander, RJ Supplement 2, S593. Simes, I Marschner. Progression Free Survival (PFS) is a valid surrogate end point for overall survival (OS) in first Pei Ni Ding, Sally Lord, Matthew Links, Victoria Bray, line treatment of advanced epithelial ovarian cancer (EOC). Val Gebski, James C. Yang, Chee Khoon Lee. Toxicity Poster, ASCO Annual Meeting, Chicago, June 2012.

67 2012 National Angelina Tjokrowidjaja, Chee K Lee, Nehmat Houssami, Sally J Lord. Metastatic breast cancer (MBC) in young K Sjoquist Interpreting Clinical Trial Data: Prognostic women: A population-based cohort study to describe risk, and Predictive Factors Invited speaker, Cancer characteristics and prognosis. SABCS 2013. San Antonio Pharmacy Practitioners Advanced Course November 2012, Breast Cancer Symposium 10-14 December 2013 San Melbourne. Antonio, Texas USA. K Sjoquist Targeted Therapies – assessing and grading Chee Khoon Lee, Lucy Davies, Val Gebski, Sally Lord, common toxicities Invited speaker, Australasian Angelo Di Leo, Stephen Johnston, Charles Geyer Jr, David Gastrointestinal Trials Groups (AGITG) Annual Scientific Cameron, Michael Press, Catherine Ellis, John Simes, Paul Meeting September 2012, Sydney. De Souza. HER2 Extracellular Domain (ECD): A Predictive 2013 International Marker of Lapatinib Treatment Benefit in Advanced Breast Cancer. SABCS 2013. San Antonio Breast Cancer Michael M. Vickers, Dongsheng Tu, Chee Lee, Paul Symposium 10-14 December 2013 San Antonio, Texas Wheatley-Price, Wendy Parulekar, Michael Donald USA. Brundage, Malcolm J. Moore, Heather-Jane Au, Christopher J. O’Callaghan, Derek J. Jonker, Jolie Ringash, Fox, P., B. Gao, B. Balakrishnar, A. M. Menzies, V. Gebski, David Goldstein. Significance of baseline quality of life S. Coulter, C. Liddle, R. Hui, R. Kefford, J. Lynch, N. scores in predicting clinical outcomes in an international Wilcken, R. L. Balleine and H. Gurney (2013). Factors phase III trial of advanced pancreatic cancer: NCIC CTG predicting endoxifen level in a tamoxifen dose escalation PA.3. Journal of Clinical Oncology, ASCO Annual Meeting study of breast cancer patients. ASCO. 31 May-4 June Proceedings 2013; 31, No 15_suppl (May 20 Supplement): 2103 Chicago, USA. 4053. Kirby, R., N. Alzahrani, J. Zhao, T. Chua, W. Liauw and D. Martin R. Stockler, Felix Hilpert, Michael Friedlander, Morris (2013). P-0153 Peritonectomy results at St George Hospital, Sydney Australia at 677 Procedures (Poster). Madeleine King, Lari B. Wenzel, Chee Lee, Florence Joly, Nikolaus De Gregorio, Jose Angel Arranz Arija, Mansoor ESMO 15th World Congress on Gastrointestinal Cancer, Raza Mirza, Roberto Sorio, Ulrich Freudensprung, Vesna 3–6 July 2013, Barcelona, Spain. Sneller, Gill Hales, Eric Pujade Lauraine and AURELIA Investigators. Health-related quality of life (HRQoL) results from the AURELIA trial evaluating bevacizumab (BEV) plus chemotherapy (CT) for platinum-resistant recurrent ovarian cancer (OC). ASCO Annual Meeting Proceedings 2013, 31 May-4 June 2103 Chicago, USA.

Angelina Tjokrowidjaja, Chee Lee, Martin R. Stockler. Does chemotherapy improve survival in muscle-invasive bladder cancer (MIBC)? A systematic review and meta- analysis (MA) of randomized controlled trials (RCT). Journal of Clinical Oncology, ASCO Annual Meeting Proceedings 2013; 31 May-4 June 2103 Chicago, USA.

Chee Khoon Lee, Alan Coates, Malcolm Hudson, Karin Ribi, Jürg Bernhard. Prognostic significance of quality- of-life scores in early stage and relapsed breast cancer: results from seven randomized trials of the International Breast Cancer Study Group. SABCS 2013. San Antonio Breast Cancer Symposium 10-14 December 2013 San Antonio, Texas USA.

68 > Department of Palliative Care, St George Hospital & Calvary Health Care Sydney

Head of Department Cancer Institute NSW. Sanderson C, Lobb EA, Upfront Family Meetings for Community Palliative Care Services. Dr. Jan Maree Davis B.Med (Hons) FRACP FAChPM Evidence to Practice Grant 2013-2014. $50,000.

Senior Medical Cancer Institute NSW. Innovation Grant Lobb EA, Hanson Dr. Frank Brennan MB BS FRACP FAcHPM S, Sanderson C, Links M, Liauw W. Retrospective case Dr. Judith Lacey MBBS FRACP FAcHPM review and analysis of clinical journey of 100 consecutive Dr. Christine Sanderson BA, BMBS, MPH, FRACP deaths in the Oncology Unit at St. George Hospital, 2013 Dr Linda Sheahan, Staff Specialist FRACP, M. Bioethics $25,000.

Research Cancer & palliative Care Research & Evaluation Unit – University of Western Australia. Monterosso L, Lobb EA, Professor Elizabeth Lobb PhD., MAppSci, B.AdEd. Joske, D, White K, Young, K, Platt V, Krishnasamy, M, Professor of Palliative Care (Allied Health), Calvary Health Yates P, Johnson C. Defining unmet needs of haematology Care Sydney and Cunningham Centre for Palliative Care; survivors: An exploratory study to inform intervention Adjunct Professor, School of Medicine, the University of development. 2012. $19,985. Notre Dame, Sydney. Churchill Fellowship, Sheahan, L. Exploring the Interface Dr. Christine Sanderson, BA, BMBS, MPH, FRACP between Palliative Care and Legalised Physician Assisted Staff Specialist in Palliative Medicine, Calvary Health Care Dying. 2012 $20000. Sydney; Research Fellow, CareSearch, Flinders University of South Australia, PaCCSC (Palliative Care Clinical Studies St. George Hospital Cancer Care Centre, Lobb EA, Lane Co-operative Investigator L, Lacey, J, Kelly B, Chochinov H, Agar M. AIs Kearsley J, Liauw W, Mason C, Ingham J, Garrard J. A pilot study Dr. Jane Mowll PhD, Research Associate of an intervention to facilitate communication between Ms. Lesley White, RN couples on end-of-life issues.. 2012-2013. $42,000. Ms. Louise Bryce, RN Ms. Victoria Tait, RN Cancer Institute NSW, Agar M (CI), Davidson P, Clark K, Ms Mary Heidenreich RN Phillips J, Xuan W, Sanderson C, Lobb E, Lovell M, Luckett Ms. Anne Johnson, Senior Social Worker T, Clayton J, Chye R, Liauw W, Chang S, Hardy J (AIs). Improving Palliative Care through Clinical Trials (ImPaCCT) Research Grants - the NSW collaborative trials group in palliative care. Cooperative Clinical Trial Grant. 2013-2016. $295,484. Australian Government DIISR Research Collaborative Research Network, University of Notre Dame Phillips J and Mary Philippa Brazill Foundation, Phillips JL, Lobb EA, Lobb EA. Palliative Care: Translating evidence into action Lynch S, Ingham J. A study to build the capabilities of to improve outcomes for palliative care patients and their Australian undergraduate medical and nursing students to care givers. 2013 – 2017. $760,000. respond to requests to hasten death.. 2013. $4,000

Australian Government, DIISR Collaborative Research Research Projects in Progress Network, University of Notre Dame Monterosso L, Lobb EA, Bulsara M. The effect of a nurse-led haematology A pilot study of an intervention to facilitate communication survivorship clinic on patient reported anxiety and unmet between couples on end-of-life issues Lobb EA, Lane L, informational needs: a multi-site Phase II randomised Lacey, J, Kelly B, Chochinov H, Agar M. AIs Kearsley J, controlled trial. 2013 – 2017 $494,774. Liauw W, Mason C, Ingham J, Garrard J.

Cancer Council WA. Halkett GKB, Nowak A, Lobb EA, Pilot of a structured home-based support and education Agar M, Miller L, Moorin R, Shaw T. Confidence to Care: for caregivers of people with high grade glioma. Halkett Pilot of a structured home-based support and education GKB, Nowak A, Lobb EA, Agar M, Miller L, Moorin R, for caregivers of people with high grade glioma. 2013- Shaw T. 2014, $99,315. 69 Too much, too soon? The impact of treatment-focused Original Peer-Reviewed Publications genetic testing in patients newly diagnosed with breast cancer. CIs Meiser B, Mitchell G, Tucker K, Saunders C, 2012 Geelhoed E, Hopper J, Watts K. AIs: Kirk J, Lobb EA, Brennan FP. John Keats and Wilfred Owen – Mortality, Barlow-Stewart K, Friedlander M, Thewes B, Southey M, Mystery, and the Pursuit if Truth: Lessons for Palliative Gleeson M, Kelly P. Care. Journal of Palliative Care 2012; 28(2): 116-119. Palliative Care: Translating evidence into action to Brennan FP. The lonely impulse of delight. Journal of improve outcomes for palliative care patients and their Palliative Care 2012; 28(4): 297-300. care givers. Phillips J and Lobb EA. Josland E, Brennan FP, Anastasiou A, Brown MA. The effect of a nurse-led haematology survivorship clinic Developing and sustaining a renal supportive care service on patient reported anxiety and unmet informational for people with end-stage kidney disease. Renal Society of needs: a multi-site Phase II randomised controlled trial. Australasia Journal 2012; 8(1): 12-18. Monterosso L, Lobb EA, Bulsara M. Lobb, EA. The challenge of giving bad news. Medicine Confidence to Care: Pilot of a structured home-based Today 2012, Vol 13 (9).55-57. Invited paper. support and education for caregivers of people with high grade glioma. Halkett GKB, Nowak A, Lobb EA, Agar M, Rando, T.A., Doka, K.J., Fleming, S., Franco, M.H., Lobb, Miller L, Moorin R, Shaw T. EA., Murray Parkes, C. Steele, R. A Call to the Field, Omega – Journal of Death & Dying, 2012. 64 (4); 251- Upfront Family Meetings for Community Palliative Care 255. Invited paper. Services. Sanderson C, Lobb EA. Butow,PN, Lobb, EA, Jefford, M, Goldstein, D., Retrospective case review and analysis of clinical journey Eisenbruch, M., Girgis, A., King, M., Sze, M., Aldridge, of 100 consecutive deaths in the Oncology Unit at St. LJ, Schofield, P. A bridge between cultures: interpreters’ George Hospital. Lobb EA, Hanson S, Sanderson C, Links perspectives of consultations with migrant oncology M, Liauw W. patients. Supportive Care in Cancer, 2012. 20(2):235 – Defining unmet needs of haematology survivors: An 244. exploratory study to inform intervention development. Hudson, P., Lobb, EA, Thomas. K., Zordan, R., Trauer, T., Monterosso L, Lobb EA, Joske, D, White K, Young, K, Platt Quinn, K., Williams, A., Summers, M. Psycho-educational V, Krishnasamy, M, Yates P, Johnson C. group intervention for family caregivers of hospitalised A pilot study of an intervention to facilitate communication palliative care patients: pilot study. Journal of Palliative between couples on end-of-life issues. Lobb EA, Lane L, Medicine 15 (3) 277-281. 2012. Lacey, J, Kelly B, Chochinov H, Agar M. AIs Kearsley J, Zilliacus E, Meiser B, Gleeson M, Watts K, Tucker K, Lobb Liauw W, Mason C, Ingham J, Garrard J. EA, Mitchell G Are we being overly cautious? A qualitative Improving Palliative Care through Clinical Trials (ImPaCCT) inquiry into the experiences and perceptions of treatment- - the NSW collaborative trials group in palliative care. Agar focused germline BRCA genetic testing amongst women M (CI), Davidson P, Clark K, Phillips J, Xuan W, Sanderson recently diagnosed with breast cancer Supportive Care in C, Lobb, E, Lovell M, Luckett T, Clayton J, Chye R, Liauw Cancer (2012) 20(11):2949-58. W, Chang S, Hardy J (AIs). Halkett, G., Kristjanson, L., Lobb, EA., Little, J., Jiwa, A study to build the capabilities of Australian M., Shaw, T., Taylor, M.,Spry, N. Information needs and undergraduate medical and nursing students to respond preferences of women as they proceed through radiation to requests to hasten death. Phillips JL, Lobb EA, Lynch S, therapy for breast cancer. Pt Edu & Couns, 2012;86(3):396- Ingham J. 404.

Who grieves: identifying those most likely to be affected Hudson, P., Trauer, T., Lobb, EA., Williams, A., Zordan, by the death of a person with a terminal condition. Phillips R., Quinn, K., Williams, A., Summers, M. Supporting J, Currow D, Lobb EA. family caregivers of hospitalized palliative care patients: Effectiveness of a psycho-educational group intervention. Exploring the Interface between Palliative Care and BMJ Supportive & Palliative Care (2012). doi:10.1136/ Legalised Physician Assisted dying – Cross sectional Data bmjspcare-2011-000131. collection from the Australian and New Zealand context. Sheahan L. Coupe NA, Lacey J, Sanderson C. Unique Manifestations of Catecholamine Release in Malignant Pheochromocytoma: An Experience Within an Inpatient Palliative Care Unit. J Pain Symptom Manage. 2012 70 May;43(5):967-72. Kearsley, JH, Lobb, EA. “It’s not a disease we treat but a person:” Reflections of medical students from their first Newton PJ, Davidson PM, Sanderson C. An online survey rotation to an oncology and palliative care unit. Journal of of Australian physicians reported practice with the off-label Palliative Care. 29:3 / 2013; 231–235. use of nebulised frusemide. BMC Palliative Care 2012, 11:6. Lobb, EA, Lacey, J., Kearsley, J., Liauw, W., White, L., Hosie, A. Living with advanced cancer and an Sheahan L, Da Silva M, Czoli C, Zlotnik Shaul R. A uncertain disease trajectory: An emerging population Canadian Perspective on a Child’s Consent to Research in palliative care? BMJ Supportive & Palliative Care. within a Context of Family Centered Care: From Published on-line April 2013; 2013;0:1–6. doi:10.1136/ Incompatibility to Synergy. Journal of Clinical Research bmjspcare-2012-000381 and Bioethics 2012: 3 (1). Watts, K.J., Meiser, B., Wakefield, C., Barratt, A., Howard, 2013 K., Cheah, B.C., Mann, G.J., Lobb, EA, Gaff, C.L., Patel, Brennan FP. “Clock Without Hands” – Carson McCullers M.I. Online prostate cancer screening decision aid for and the Rhythm of Living and Dying. American Journal of at-risk men: A randomized trial, Health Psychology, 12 Hospice and Palliative Medicine 2013; 30(3):312-316. June 2013.Patel MI. Health Psychology, Health Psychology 11/2013, DOI:10.1037/a0034405. Urban K, Brennan FP. Patients who withdraw from dialysis in a Sydney centre with palliative care support : who, why, Sanderson, C., Lobb, EA, Mowll, J. Butow, P., Price, M. and how they die. Progress in Palliative Care. 2013; 21(6): Signs of post-traumatic stress disorder in caregivers 325-330. following an expected death: a qualitative study’ as a factual descriptor of the study. Palliative Medicine, 2013, Brennan FP. Conscientious Objector – Edna St Vincent 27(7), 625-631. Millay, mortality and the nature of Palliative Care. Journal of Palliative Care 2013; 29(2): 123-125. Sanderson C, Hardy J, Spruyt O, Currow D Placebo and nocebo effects in randomised controlled trials - the Brennan FP, Brown M. The ethics of dialysis – an alliance implications for research and practice. Journal of Pain and of Nephrology, Palliative Medicine and Ethics. Quarterly Symptom Management: Vol. 46 No. 5 November 2013. Journal of Medicine 2013; 106(5): 397-400. Heidenreich MT, White K, Kuen Koo F The experience Brennan FP. The New World of Ourselves. Journal of of Chinese immigrant women in caring for a terminally Palliative Care. 2013; 29(4): 258-259. ill family member in Australia, Collegian 03 July 2013 (10.1016/j.coleg.2013.06.002). Brennan FP. Ethical Principles for Patients, Families and Doctors to Consider. Nephrology 2013; 18: 413-414. Other published material

Brennan FP, Siva B, Crail S. Appropriate Assessment of 2012 Symptom Burden and Provision of Patient Information. Nephrology 2013; 18: 418-421. Lobb, EA. Chapter: “The selfsame well: Perspectives on human suffering in loss, grief and bereavement”. Book Brennan FP. Holistic Palliative Care Approach - Physical, – Perspectives on Human Suffering, proceedings from Spiritual, Religious and Psychological Needs. Nephrology Colloquium on Human Suffering, Hobart, February 2012. 2013;18: 421-423. Elservier. Editors J. Malpas and N. Lickiss, C. Sanderson.

Siva B, Brennan FP. Inappropriate Interventions in the Sanderson, C. Webpage for CareSearch. Dementia Dying Patient. Nephrology 2013; 18: 423-424. (including evidence summaries on palliative care challenges; caregivers and care settings; prognosis and Stewart C, Brennan FP. Legal Issues Concerning advance care planning; symptom management.) http:// Withholding and Withdrawal of Dialysis. Nephrology 2013; www.caresearch.com.au/caresearch/tabid/2785/Default. 18: 444-449. aspx, accessed May 29, 2013. Lim CED, Siow S, Ho KEH, Chua JL, Chong N, Cheng L, Brennan FP. Renal Palliative Care – A Reader. 2012. Vision Kwok, Brennan FP, Cigolini M. Advance Care planning in Media, Sydney. haemodialysis patients. Protocol Information. Cochrane Reviews. Review number 294. September 2013. Brennan FP. Suffering seeks a voice. In: Malpas J and Lickiss N (eds). Perspectives on Human Suffering. 2012. Brennan FP, Murrell DF. Report from the Inaugural Springer Publishing. Australian Pruritus Symposium, Sydney, Australia, August 10 2013. Acta Derm Venereol 2013. Oct 24 [Epub ahead of publication]. 71 Presentations at Scientific Meetings and sub-threshold prolonged grief disorder (PGD) amongst Conferences bereaved cancer caregivers: Implications for bereavement services Clinical Oncological Society of Australasia Annual 2012 – International Scientific Meeting, Melbourne.

Lobb, EA, Price, M., McGowan, N., Mowll, J Butow, PN. Brennan, FP. Palliative Care Physicians don’t just palliate. “Palliative care services and a ‘good death’; learning Renal Home Therapies Conference, Sydney. March 15. from family care-givers” 19th International Congress on Palliative Care, Montreal 9-12 October Brennan, FP. How Do We Stop ? Withdrawal From Dialysis. Renal Home Therapies Conference, Sydney. March 15. Kearsley, J & Lobb, EA. “It is not a disease we treat but a person”: Reflections of medical students on their first Brennan, FP. Renal Supportive Care – An Overview and rotation to an oncology and palliative care term”. 19th Recent Developments. NSW Palliative Care Education Day, International Congress on Palliative Care, Montreal 9-12 Royal Prince Alfred Hospital. May 25. October, 2012 Brennan, FP. Symptom management in patients Lobb, EA, Price, M., McGowan, N., Mowll, J Butow, PN. with Chronic Kidney Disease. Renal Supportive Care “Palliative care services and a ‘good death’; learning Symposium, St George Hospital. August 10. from family care-givers” 19th International Congress on Brennan, FP. Nephrology- Medical, Ethical and Legal Palliative Care, Montreal 9-12 October. Dimensions. Renal Supportive Care Symposium, St George Hudson, P, Trauer, T, Lobb, EA, Zordan, R. Williams, A., Hospital. Case based discussion with Dr Su Crail, Professor Quinn, K., Summers, M., Thomas, K., Supporting family Cameron Stewart and Bernadette Tobin. August 10. caregivers of hospitalized palliative care patients: A Brennan, FP.. What is new in Renal Supportive Care ? (Co- psycho-educational group intervention. 19th International presented with Liz Josland and a video presentation by Congress on Palliative Care, Montreal 9-12 October. Gemma Collett) August 10. Brennan, FP. The management of pain and other Brennan, FP..Symptom management in patients symptoms in patients with End Stage Kidney Disease. with Chronic Kidney Disease. Renal Supportive Care Australian and New Zealand Society of Nephrology Symposium, St George Hospital. August 10. Meeting, Auckland, New Zealand, August 26. 2013 - International Heidenreich MT, White K, Kuen Koo F. Caring Is a Lonely and Isolating Experience: Immigrant Chinese Women’s Lobb, EA, Lane, L., Lacey, J., Chochinov, HM, Kelly, B. Experience in Caring for a Terminally Ill Relative at Home Agar, M., Mowll, J., Links, M., Kearsley, JH, Liauw, W., in New South Wales, Australia. 19th International Congress Lynch, J. A pilot study of an intervention for couples to on Palliative Care. Montreal, Canada. October. facilitate communication about end of life issues where one member of the couple has incurable cancer. 15th 2012 – National World Congress on Psycho-oncology, Rotterdam, 4-8th Mowll, J., Lobb, EA, Price, M., McGowan, N., Butow, PN. November (oral). Features of gender and grief reported in the experiences Sanderson, C, Lobb, EA, Mowll, J, Butow, PN, McGowan, of family care-givers six months after a family member’s N., Price, MA. The sights and sounds of palliative care: death from ovarian cancer. Clinical Oncological Society of Caregivers’ experiences at the deathbed: A qualitative Australasia Annual Scientific Meeting, Melbourne study. 15th World Congress on Psycho-oncology, Halkett, G., Nowak, A., Lobb, EA, Long, A. Fournier, Rotterdam, 4-8th November. (poster) C., Nowak, A. Carers of patients with HGG are more Lobb, EA, Lacey, J, Liauw, W, White, L., Hosie, A, Kearsley, distressed than the patients: Understanding the J. A re-assessment of meaning-making in patients with experience of caring for people living with High Grade early-diagnosed incurable cancer. 15th World Congress on Glioma Clinical Oncological Society of Australasia Annual Psycho-oncology, Rotterdam, 4-8th November. Scientific Meeting, Melbourne. Hosie, A., Phillips, J., Agar, M., Lobb, EA, Davidson, Calford, BR, Zilliacus, E., Meiser, B., Lobb, EA, Spigelman, P. Exploring recognition and assessment of delirium A, Tucker, K. The Process and Content of Tele-health symptoms by palliative care nurses using the Critical Cancer Genetic Counselling, Clinical Oncological Society Incident Technique. 8th Annual Meeting of the European of Australasia Annual Scientific Meeting, Melbourne. Delirium Association; Leuven, Belgium, September 20-21 Zordan, R., Remedios, C., Price, M., Lobb, EA, Hall, C., (oral). Hudson, P. The prevalence and predictors of threshold and 72 Brennan FP, Palliative Care in End Stage Renal Disease. Brennan FP, Renal Supportive Care in adult patients – Asia Pacific Hospice and Palliative Care Network An Overview . Paediatric Palliative Care Symposium, Conference, Bangkok, Thailand. October 11. Westmead Childrens’ Hospital. March 7.

Brennan FP,. Engaging Palliative care in non-cancer Brennan FP, The experience of establishing a Renal patients. Asia Pacific Hospice and Palliative Care Network Supportive Care Service. Nephrology Scientific Conference, Bangkok, Thailand. [Plenary speech] October Symposium. Melbourne, Victoria. April 20. 12. Brennan FP, Pain in non-malignant diseases including End Brennan FP, Morality and Ethics in the withdrawal of Stage Kidney Disease. Pain Symposium. Pain Institute treatment. Asia Pacific Hospice and Palliative Care Royal North Shore Hospital, Sydney. May 4. Network Conference, Bangkok, Thailand. October 13. Brennan FP, Renal Supportive Care – An Overview. The Brennan FP, Renal Supportive Care – An Overview. All Physicians’ Forum. Concord Hospital, Sydney, July 11. Ireland Palliative Care Institute, Dublin, Ireland. April 29. Brennan FP, What is new in Renal Supportive Care? Renal 2013 National Supportive Care Symposium, St George Hospital, Sydney, August 9. Lobb, EA, Sanderson, C, Mowll, J., Butow, PN, Price, M. “The Sights and Sounds of Palliative Care” Caregiver’s Brennan FP, The pathogenesis and management experiences at the deathbed: A qualitative study”. 12th of Restless Legs Syndrome. Renal Supportive Care Australian Palliative Care Conference National Convention Symposium, St George Hospital, Sydney, August 9. Centre in Canberra, 3-6 September. Brennan FP, The pathogenesis of pruritus. Pruritus Sanderson, C., Johnson, A., Lobb, EA, Mowll, J. “Do Symposium. St George Hospital, Sydney. August 10. early patient-centered family meetings reduce patient and Brennan FP, The pathogenesis and management of family distress at first admission for in-patient palliative Uraemic Pruritus. Pruritus Symposium. St George Hospital, care”? 12th Australian Palliative Care Conference the Sydney, August 10. National Convention Centre in Canberra, 3-6 September. Brennan FP, Management and Advance Care Planning in Hosie, A., Phillips, J., Agar, M., Lobb, EA, Davidson, patients with End Stage Kidney Disease. Clinical Ethics P. Exploring recognition and assessment of delirium Forum - Ethics, End of Life and Advance Care Planning. symptoms by palliative care nurses: a qualitative study”. Royal Hospital for Women, Randwick, Sydney. September 12th Australian Palliative Care Conference, National 27. Convention Centre in Canberra, 3-6 September. Heidenreich MT, White K, Kuen Koo F Caring Is a Lonely Sanderson, C., Johnson, A., Lobb, EA, Mowll, J. Studying and Isolating Experience: Immigrant Chinese Women’s family meetings: what have we learned and what should Experience in Caring for a Terminally Ill Relative at Home we measure? 12th Australian Palliative Care Conference in New South Wales, Australia. 12th Australian Palliative to be held at the National Convention Centre in Canberra, Care Conference. Canberra, ACT, 3-6 September. 3-6 September. Heidenreich MT, White K, Kuen Koo F. Chinese family Kadwell, L., Usher, J., Gilbert, E, Lobb EA. “Talking about obligations: Confucian cultural beliefs influencing palliative sexuality and intimacy is everyone’s business” Health care for Chinese families and female carers in Australia. professionals communication in the context of cancer and 12th Australian Palliative Care Conference. Canberra, ACT, palliative care” 12th Australian Palliative Care Conference, 3-6 September. National Convention Centre in Canberra, 3-6 September.

Sheahan, L., Churchill Fellowship report findings: Exploring Community Engagement the Interface between Palliative care and Legalised Lobb, EA. Appointed to Executive Committee of ACI Physician. Palliative Care Network 2012. Assisted Suicide/Voluntary Euthanasia. Palliative Care Lobb, EA. Appointed member of Expert Advisory Group Australia Conference, Canberra, August. on Bereavement Search filter – CareSearch, 2012. Brennan FP, Renal Supportive Care – An Overview. Kearsley, J., Lacey, J., Lobb, EA, Sanderson, C., White, Department of Nephrology, John Hunter Hospital, L. Organising Committee – Whole Person Care Public Newcastle. February 14. Lecture – Professor Eric Cassell, UNSW, 2nd September, 2013.

73 Kearsley, J., Lacey, J., Lobb, EA, Sanderson, C., White, L. Organising Committee – Whole Person Care Symposium, Sydney, May, 2012.

74 > Department of Radiation Oncology

Head of Department Junli (Cindy) Deng PhD student Ning (Sophia) Li Visiting Fellow (Medical Oncologist) Professor J H Kearsley MBBS (Hons Syd) FRACP FRANZCR Oliver Fio ILP student

Senior Medical Allied Health

A/Professor Peter Graham MBBS, FRANZCR, Cert Julia Maclean PhD M.Sc (Medicine) B.App. Sc (Speech Bioethics, Grad Dip Medical Statistics Pathology), BA (Linguistics/Psychology) Dr Joseph Bucci MBBS FRACP FRANZCR Wendy Relf, M. HealthSc (Comms), B.App. Sc (Speech Dr Catherine Clark MBBS FRANZCR Pathology), BA (Linguistics/Psychology). Dr Yaw Chin BSc (Med) FRANZCR Dr Eric Hau BSc (Med), MBBS, Grad Cert (Biostat), Research Grants FRANZCR NHMRC Project Grant, Principal Investigators: Cook I, Junior Medical Szczesniak M, Maclean J, Graham P, Omari T. Predicting dysphagia-related complications and improving outcomes Dr Nadine Beydoun in patients treated with head and neck radiotherapy. Dr Eric Hau $301,624 (2012-2014). Dr Ariyanto Pramana Dr Mimi Tieu NHMRC Career Development Fellow (Level 2) Principal Dr Dominique Lee Investigators: A/Professor Yong Li Dr Alex Petruvski Identification of novel biomarkers in urine to improve Dr Chelsea Connor diagnosis and monitor progression in prostate cancer. $417,000 (2010-2014). Research Staff - Clinical Trials Unit ARC-linkage Grant Principal Investigators: A/Professor Peter Fink BSc, Clinical Trials Unit Manager –Radiation Yong Li, Dr Paul Cozzi, M. Willcox, B. Walsh. Proteomic Oncology study of urine to discover novel biomarkers for human Trials Co-ordinators prostate cancer. $150,000 (2010-2013). Helen Cox BSc Sima Don PhD Cancer Australia / National Breast Cancer Foundation, Faith Koh MPH Principal Investigators: Holloway L, Metcalfe P, Lazarus Mary MacFarlane RN E, Delaney G, Batumalai V, Vial P, Koh E-S, Associate Kylie Melki - BBioTech Investigators: Quinn A, Jameson M, Hargreaves B, Moran Sharon Parkes BSc C, Keall P, Collins L, Shafiq J, Rozenfeld A, Lonergan Xiaolu Wang M HealthAdmin D, Papadatos G, Lim K, Ahern V, Drummond R, Tiver K, Xiaobing Ma BMed Graham P, Ramsay J. Breast MRI in radiotherapy planning. Victoria Stevens BPharm $391,596 2012-2015.

Senior Researchers Cancer Australia Project Grant, Principal Investigators: A Prof P Graham, Prof G Delaney, Dr E Millar, Dr Anne A/Professor Yong Li: Principal Scientific Officer and Head Capp. AIs: Prof R Sutherland, Dr S Carroll, Dr J Harvey, Dr of Cancer Research Program J Lynch , Dr R Tse. TROG 08.06; A randomised comparison Dr Jingli (Helen) Hao: Hospital Scientist, Conjoint Lecturer of anastrozole commenced before and continued during of UNSW adjuvant radiotherapy for breast cancer versus anastrozole and subsequent anti-oestrogen therapy delayed until Research Students after radiotherapy. (STARS - Study of Anastrozole and Julia Beretov Scientific Officer and PHD student Radiotherapy Sequencing), $660,000 (2010-2012). Lei (Nancy) Chang PhD student

75 Research Projects in Progress Feasibility of Using Polyethylene Glycol Hydrogel to Increase Prostate-Rectum Separation and Its Impact A randomised comparison of Anastrozole commenced on Rectal Dose during Radiation Therapy. Principal before and continued during adjuvant radiotherapy Investigator: Dr Nadine Beydoun. for breast cancer versus Anastrozole and subsequent anti-oestrogen therapy delayed until after radiotherapy. Evaluating the Utility of a Patient Decision Aid for Principal Investigator: A/Professor Peter Graham. Prospective Participants in the TROG RAVES Prostate Cancer Trial (TROG 08.03) Principal Investigator: Dr Determining the needs of Grade III-IV High Grade Glioma Joseph Bucci. patients. Principal Investigator: Professor John Kearsley. A Phase II Study of Stereotactic ablative Body A collaborative randomised phase III trial: The timing of Radiotherapy(SABR) for Stage I NSCLC. Principal intervention with androgen deprivation in prostate cancer Investigator: Dr Eric Hau. patients with a rising PSA. Principal Investigator: Dr Joseph Bucci. Identification of novel biomarkers in tears for breast cancer diagnosis and monitoring. Principal Investigators: A/ Randomised trial investigating the effect on survival and Professor Yong Li, A/Professor Peter Graham, M Willcox , V PSA control of different durations of adjuvant androgen Wasinger and Professor John Kearsley . deprivation in association with definitive radiation treatment for localised carcinoma of the prostate (RADAR). PI3K/Akt/mTOR signalling pathway in prostate cancer Principal Investigators: Dr Joseph Bucci. radioresistance. Principal Investigators: A/Professor Yong Li, A/Professor Peter Graham, Professor John Kearsley and A phase III study of regional RT in early breast cancer Dr Joseph Bucci. (NCIC MA20). Principal Investigator: A/Professor Peter Graham. Identification of novel biomarkers associated with prostate cancer radioresistance. Principal Investigators: A/Professor STARS Pilot Breast Trial: A randomised comparison of Yong Li, A/Professor Peter Graham, Dr Paul Cozzi, Anatrazole commenced before and continues during Professor John Kearsley and Dr Joseph Bucci. radiotherapy for breast cancer versus Anastrazole and subsequent Anti-Oestrogen therapy delayed until after Investigating the roles of CD44v6 and CD326 in prostate radiotherapy. Principal Investigator: A/Professor Peter cancer metastasis and chemo- radioresistance. Principal Graham. Investigators: A/Professor Yong Li, Dr Paul Cozzi, A/ Professor Peter Graham, and Professor John Kearsley. A randomised comparison of breast conservation with or without lumpectomy radiotherapy boost Predicting dysphagia-related complications and improving Principal Investigator: A/Professor Peter Graham outcomes in patients treated with head and neck Pulmonary Fibrosis following breast conservation adjuvant radiotherapy. Principal Investigators: Professor Ian Cook, radiotherapy: the modifying effects of systemic therapies Dr Michal Szczesniak, Dr Julia Maclean, A/Professor (chemotherapy and Tamoxifen. Principal Investigator: A/ Peter Graham, Dr Taher Omari. Prospective, randomized Professor Peter Graham. controlled trial of cricopharyngeal dilatation in post- laryngectomy dysphagia. Principal Investigators: Dr Peter A Randomised Phase III Study of Radiation Doses and Wu, Professor Ian Cook, Dr Michal Szczesniak, Dr Julia Fractionation Schedules in Non-Low Risk Ductal Carcinoma Maclean. In Situ (DCIS) of the Breast. Principal Investigator: A/ Professor Peter Graham. Influence of Altered Pharyngo-esophageal Biomechanical Parameters on Swallowing and Speech Function in A randomised phase II/III trial of preoperative Laryngectomees. Principal Investigators: Ms Teng Zhang, chemoradiotherapy versus preoperative chemotherapy Professor Ian Cook, Dr Michal Szczesniak, A/Prof Paul for resectable gastric cancer. Principal Investigator: Dr Yaw Bertrand, Dr Julia Maclean. Chin. Original Peer-Reviewed Publications RAVES: Radiotherapy - Adjuvant Versus Early Salvage. A phase III multi-centre randomised trial comparing adjuvant 2012 radiotherapy (RT) with early salvage RT in patients with positive margins or extraprostatic disease following radical Beydoun, N., Graham, P. H., & Browne, L. (2012). prostatectomy. Principal Investigator: Dr Joseph Bucci. Metastatic cutaneous squamous cell carcinoma to the axilla: A review of patient outcomes and implications for Phase II Study of Accelerated Partial Breast Irradiation future practice. World Journal Oncology, 3(5), 217-226. Using Interstitial Multi-Catheter High Dose Rate Brachytherapy. Principal Investigator: Dr Yaw Chin. Graham, P., Plant, N., Graham, J., Browne, L., Borg, M., 76 Capp, A., Delaney, G., Harvey, J., Kenny, L., Francis, M., either CD44 or CD147. PLoS ONE 2012;7:e40716. & Zissiadis, Y. (2012 ). Digital photography as source Ni J, Cozzi PJ, Duan W, Shigdar S, Graham P, Kearsley documentation of skin toxicity: An analysis from the J, Li Y. Role of the EpCAM (CD326) in prostate cancer Trans Tasman Radiation Oncology Group (TROG) 04.01 metastasis and progression. Cancer and Metastasis Post-Mastectomy Radiation Skin Care. Journal of Medical Reviews 2012; 31:779-791. Imaging and Radiation Oncology, 56, 458-463. Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley Hao, J., Madigan, M. C., Khatri, A., Power, C. A., Hung, J, Li Y. Epithelial mesenchymal transition (EMT) is involved T.-T., Beretov, J., Chang, L., Xiao, W., Cozzi, P. J., Graham, in the prostate cancer radiation resistance. Asia-Pacific P. H., Kearsley, J. H., & Li, Y. (2012). In Vitro and In Vivo Journal of Clinical Oncology 2012; 8(Supplement 3): 333. Prostate Cancer Metastasis and Chemoresistance Can Be Modulated by Expression of either CD44 or CD147. PLoS 2013 ONE, 7(8), e40716. Ball, D. L., R. J. Fisher, B. H. Burmeister, M. G. Poulsen, P. Hau, E., Browne, L. H., Khanna, S., Cail, S., Chin, Y., H. Graham, M. G. Penniment, S. K. Vinod, H. E. Krawitz, Clark, C., Inder, S., Szwajcer, A., & Graham, P. (2012). D. J. Joseph, G. C. Wheeler and B. E. McClure (2013). The Radiotherapy Breast Boost With Reduced Whole-Breast complex relationship between lung tumor volume and Dose Is Associated With Improved Cosmesis: The Results survival in patients with non-small cell lung cancer treated of a Comprehensive Assessment From the St. George and by definitive radiotherapy: A prospective, observational Wollongong Randomized Breast Boost Trial. International prognostic factor study of the Trans-Tasman Radiation Journal of Radiation Oncology Biology Physics, 82(2), 682- Oncology Group (TROG 99.05). Radiotherapy and 689. Oncology 106(3): 305-311.

Hau, E., & Graham, P. (2012). A brief review on the Beydoun, N., Bucci, J., Chin, Y., Spry, N., Newton, R., biological effects of radiation on cells. The Radiographer, and Galvão, D., (2013). Prospective study of exercise Volume 59(3), 89-97. intervention in prostate cancer patients on androgen deprivation therapy. Journal of Medical Imaging Kearsley, J. (2012). An exquisite presence (after Buber). and Radiation Oncology: epub, DOI: 10.1111/1754- Palliative & Supportive Care, 10(04), 307-307. 9485.12115. Ni, J., Cozzi, P., Duan, W., Shigdar, S., Graham, P., Kearsley, Chao, H., Wang, L, Hao, J, Ni, J, Chang, Li, Graham, P, J., & Li, Y. (2012). Role of the EpCAM (CD326) in prostate Kearsley, J and Li, Y (2013). Low dose histone deacetylase cancer metastasis and progression. Cancer and Metastasis inhibitor, LBH589, potentiates anticancer effect of Reviews, 31(3-4), 779-791. docetaxel in epithelial ovarian cancer via PI3K/Akt pathway Pramana, A., Browne, L., & Graham, P. H. (2012). in vitro. Cancer Letters 329(1): 17-26. Metastatic cutaneous squamous cell carcinoma to parotid Chao, H., Wang, L, Hao, J, Ni, J, Chang, Li, Graham, P, nodes: The role of bolus with adjuvant radiotherapy. Kearsley, J and Li, Y (2013). Low dose histone deacetylase Journal of Medical Imaging and Radiation Oncology, inhibitor, LBH589, potentiates anticancer effect of 56(1), 100-108. docetaxel in epithelial ovarian cancer via PI3K/Akt pathway Xiao, W., Graham, P., Power, C., Hao, J., Kearsley, J., in vitro. Cancer Letters 329(1): 17-26. & Li, Y. (2012). CD44 is a biomarker associated with Graham, P, Plant N, Graham J, L. Browne, M. Borg, A. human prostate cancer radiation sensitivity. Clinical and Capp, G. P. Delaney, J. Harvey, L. Kenny, M. Francis and Experimental Metastasis, 29(1), 1-9. Y. Zissiadis (2013). A Paired, Double-Blind, Randomized Xiao W, Graham P, Power C, Hao JL, Kearsley J, Li Y. Comparison of a Moisturizing Durable Barrier Cream to CD44 is biomarker correlated with human prostate cancer 10% Glycerine Cream in the Prophylactic Management radiation sensitivity. Clinical & Experimental Metastasis of Postmastectomy Irradiation Skin Care: Trans-Tasman 2012; 29:1-9. Radiation Oncology Group (TROG) 04.01. International Journal of Radiation Oncology Biology*Physics 86(1): 45- Shigdar S, Lin J, Li Y, Yang CJ, Wei M, Zhu Y, Liu H, Duan 50. W. Cancer stem cell targeting: the next generation of cancer therapy and molecular imaging. Therapeutic Hao, J., Ni, J, Graham, P, Cozzi, P, Bucci, J. Kearsley, J Delivery 2012; 3:227-244. and Li, Y (2013). “The CD44 Isoforms in Prostate Cancer Metastasis and Progression. World Journal of Cancer Hao J, Madigan M, Khatri A, Power C, Hung T, Beretov Research 1(1): 3-14. J, Chang L, Xiao W, Cozzi P, Graham P, Kearsley J, Li Y. In vitro and in vivo prostate cancer metastasis and Hau, E, Browne L., Capp A., Delaney G. P, Fox, C, chemoresistance can be modulated by expression of Kearsley, J, Millar, E. Nasser, E, Papadatos G and Graham, 77 P (2013). The impact of breast cosmetic and functional with activation of the PI3K/Akt/mTOR pathway in prostate outcomes on quality of life: long-term results from the St. cancer radioresistance. Cell Death and Disease. 2013; George and Wollongong randomized breast boost trial. 4:e875. Breast Cancer Research and Treatment: 1-9. Krishnan, S. and Maclean J (2013). Practice of Haworth, A., L. Wilfert, D. Butler, M. A. Ebert, S. Todd, laryngectomy rehabilitation interventions: a perspective J. Bucci, G. M. Duchesne, D. Joseph and T. Kron (2013). from Australia. Current Opinion in Otolaryngology and Australasian brachytherapy audit: Results of the ‘end-to- Head and Neck Surgery 21(3):224-229. end’ dosimetry pilot study. Journal of Medical Imaging and Radiation Oncology: Volume 57, Issue 4, pages Other Published Material 490–498, August 2013. You J, Cozzi PJ, Fitzgerald A, Walsh B, Russell PJ, Willcox Lobb, E. A., J. Lacey, J. Kearsley, W. Liauw, L. White M, Graham P and Li Y. Prostate cancer biomarkers and and A. Hosie (2013). “Living with advanced cancer and the emerging proteomic techniques used in biomarker an uncertain disease trajectory: an emerging patient research. Horizons in Cancer Research, edited by Hiroto S. population in palliative care?” BMJ Supportive & Palliative Watanabe. Nova Science Publishers, Inc. USA. 2012;47:1- Care. Vol 27, No 34, 2009: pp. 5757-5762. 36.

Chao H, Wang L, Hao J, Ni J, Chang L, Graham P, Kearsley Perry, A. and Maclean, J. (2012) Rehabilitation after J, Li Y. Combination of the histone Deacetylase inhibitor Treatment for Recurrent Head and Neck Cancer. In H. LBH589 with Docetaxel is highly effective in treating Mehanna and K. Ang (Eds), Head and Neck Cancer human epithelial ovarian cancer. Cancer Letters. 2013; Recurrence: Evidence-based, Multidisciplinary 329:17-26. Management (pp. 253-259). Germany: Thieme. Hao JL, Ni J, Graham P, Cozzi P, Bucci J, Kearsley J and Li You J, Willcox M, Madigan MC, Wasinger V, Schiller B, Y. The CD44 isoforms in prostate cancer metastasis and Walsh B, Graham P, Kearsley J and Li Y. Tear as a source progression. World Journal of Cancer Research 2013; 1:1- of protein biomarkers for human disease diagnosis and 12. prognosis. Advancers in Clinical Chemistry, edited by Greg Xiao W, Graham P, Hao JL, Chang L, Ni J, Power C, Dong Makowski, Elsevier. 2013; 62:151-187. Q, Kearsley J and Li Y. Combination therapy with the Maclean, J – Co-Author - ACI - Care of adult patients in histone Deacetylase inhibitor LBH598 and radiotherapy is acute care facilities with a tracheostomy – Clinical Practice an effective regimen for prostate cancer cells. PloS ONE. Guideline 2013. 2013; 8:e74253. Maclean, J – Co-Author - Speech Pathology Australia - Shigdar S, Qian C, Lv L, Pu C, Li Y, Li L, Marappan M, Li J, Clinical Guideline – Laryngectomy Management 2012. Wang L, Duan W. The use of sensitive chemical antibodies for diagnosis: detection low levels of EpCAM in breast Presentations at Scientific Meetings and cancer. PloS ONE. 2013; 8:e57613. Conferences

Shigdar S, Qian L, Zhou SF, Xiang DX, Wang T, Li Y, Lim LY, 2012 - International Kong LX, Li LH, Duan W. RNA aptamers targeting cancer stem cell marker CD133. Cancer Letters. 2013; 330:84-95. Xiao W, Graham P, Power C, Dong QH, Cozzi PJ, Kearsley J and Li Y (2012). The histone deacetylase inhibitor Deng JL, Wang L, Chen HM, Li L, Ma YM, Ni J, Li Y. The LBH589 combined with radiation is an effective regimen role of tumour-associated MUC1 in epithelial ovarian for prostate cancer. Advances in prostate cancer research- cancer metastasis and progression. Cancer and Metastasis AACR special conference, 6-9 Feb. Orlando USA. Reviews. 2013; 32:535-551. Wang L, Chen HM, Liu FH, Beretov J, Hao JL, Chao HT, Ni J, Cozzi P, Hao JL, Beretov J, Chang L, Duan W, Perkins AC, Kearsley J and Li Y (2012). Studies of the effect Shigdar S, Delprado W, Graham P, Bucci J, Kearsley J of anti-MUC1 monoclonal antibody (C595) with docetaxel and Li Y. Epithelial cell adhesion molecule (CD326) is in in vitro epithelial ovarian cancer cells and an in vivo associated with prostate cancer metastasis and chemo-/ animal model. The 3rd International Ovarian Cancer radioresistance via PI3K/Akt/mTOR signaling pathway. Symposium: Prevention, Detection and Treatment of the International Journal of Biochemical Cell Biology. 2013; Disease and Its recurrence, 10-11 May. Pittsburgh, PA, 45:2736-2748. USA.

Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Li Y, Chao HT, Wang L, Hao JL, Ni J, Graham P, Kearsley Kearsley J and Li Y. Acquisition of epithelial-mesenchymal J (2012). Combination of low dose histone deacetylase transition and cancer stem cell phenotypes is associated inhibitor, LBH589, with docetaxel is an effective option for 78 epithelial ovarian cancer treatment. The 3rd International in vitro and in vivo prostate cancer metastasis and Ovarian Cancer Symposium: Prevention, Detection and chemoresistance. 14th International Biennial Congress of Treatment of the Disease and Its recurrence, 10-11 May, the Metastasis Research Society, 2-5 September, Brisbane, Pittsburgh, PA, USA. Australia.

Beretov J, Wasinger V, Graham P, Kearsley J and Li Y Chang L, Peter G, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley (2012). Identification of novel urine biomarkers from J and Li Y (2012). Developing radiation resistant prostate metastatic breast cancer patients using proteomic cancer cell lines with epithelial mesenchymal transition approaches. Asia Oceania Human Proteome Organization (EMT) characteristic for prostate cancer treatment. The St (AOHUPO) 6th Congress, 5-7, Beijing, China. George & Sutherland Medical Research Symposium, 11 Oct, 2012, Sydney, Australia. Beretov J, Wasinger V, Graham P, Kearsley J and Li Y (2012). Proteomic identification of novel urine biomarkers- Ni J, Cozzi P, Hao JL, Beretov J, Chang L, Duan W, for the early detection of breast cancer. HUPO 11th Annual Delprado W, Graham P, Bucci J, Kearsley J and Li World Congress, September 9-13, Boston, USA. Y (2012). EpCAM (CD326) and CD44 variants are biomarkers associated with prostate cancer metastasis Maclean, J., Szczesniak, M., Zhang, T., Graham, P., and and progression. The St George & Sutherland Medical Cook, I. (2012). Dysphagia is a Prevalent and Under Research Symposium, 11 October, Sydney. Recognized Complication of Head and Neck Radiotherapy. Paper presented at. Dysphagia Research Society, Toronto, Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley USA, March 2012. J and Li Y (2012). Epithelial mesenchymal transition (EMT) is involved in the prostate cancer radiation resistance. Maclean, J., Szczesniak, M., Pramsothy, S., Zhang, T., IPOS 14th world congress and COSA’s 39th annual Graham, P., & Cook, I. (2012). Esophageal Dysmotility in scientific meeting, 13-15 November, Brisbane. Laryngectomy Patients: An Unrecognized Association?. Paper presented at Dysphagia Research Society, Toronto, Beretov J, Wasinger V, Graham P, Kearsley J and Li Y USA, March 2012. (2012). Discovering Urine Protein Biomarkers in Breast Cancer using Proteomic Technology. The St George & Kearsley, J. Analysis of student reflections: “It is not Sutherland Medical Research Symposium, 11 October, a disease we treat but a person”. Paper presented at Sydney. the Palais des Congrès,19th International Congress on Palliative Care, Montreal, Canada. October. Beretov J, Wasinger V, Peter Scwartz, Graham P, Kearsley J and Li Y (2012). Discovering Urine Protein Biomarkers in Li, Y., Chao, H., Wang, L., Hao, J., Ni, J., Graham, P. and Breast Cancer using Proteomic Technology. “Proteomics Kearsley, J. (2012). Combination of low dose histone and Beyond” Symposium, Macquarie University, 7th deacetylase inhibitor, LBH589, with docetaxel is an November, Sydney. effective option for epithelial ovarian cancer treatment. Paper presented at the The 3rd International Ovarian Ni J, Cozzi P, Hao JL, Beretov J, Chang L, Duan W, Cancer Symposium: Prevention, Detection and Treatment Delprado W, Graham P, Bucci J, Kearsley J and Li Y of the Disease and Its recurrence. Pittsburgh, PA, USA, (2012). EpCAM (CD326) is a biomarkers associated with May. prostate cancer metastasis and progression. AACBS annual scientific meeting, Sydney, 16 December 2012. 2012 - National Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley Molloy, T., Pajic, M., Holzhauser, S., Graham, P., Millar, J and Li Y (2012). Acquisition of radioresistance and EMT/ E., & Sutherland, R. (2012). Identification of miRNAs CSC phenotypes is linked with activation of the PI3K/Akt/ as potential mediators of radiotherapy resistance in mTOR pathway in prostate cancer cells. AACBS annual breast cancer. Paper presented at the 24th Lorne Breast scientific meeting, Sydney, Australia, 16 December 2012. Conference. Victoria. Maclean J, Szczesniak M, Paramsothy S, Zhang T, Graham, Ni J, Cozzi P, Beretov J, Duan W, Delprado W, Graham P, P, Cook IJ. Australian and New Zealand Head and Neck Kearsley J and Li Y (2012). Over-expression of EpCAM Cancer Society, Oesophageal dysmotility in laryngectomy (CD326) and CD44 variants in human prostate cancer cells patients: An unrecognized association, Brisbane, October, are potential therapeutic targets for targeted therapy. 2012, 13th Australasian Prostate Cancer Conference, 31 July. Melbourne. Maclean, J.C., Szczesniak M, Graham, P, Cook IJ. Australian and New Zealand Head and Neck Cancer Li Y, Hao JL, Madigan MC, Khatri A, Power CA, Hung Society, Brisbane, October, 2012, Long-term dysphagia TT, Beretov J, Xiao W, Cozzi PJ, Kearsley J (2012). following Radiotherapy. Over-expression of either CD44 or CD147 modulates 79 Maclean, J.C., Australian and New Zealand Head and Maclean, J.C., Szczesniak M, Graham, P, Cook IJ. Neck Cancer Society, Brisbane, October, 2012, invited Australian and New Zealand Head and Neck Cancer panellist IFHNOS Session 3: Multidisciplinary Therapy. Society, Melbourne, September, 2013, Cricopharyngeal dysfunction – assessment and treatment. 2013 - International Community Engagement Li Y, Wang L, Chao H, Hao J, Ni J, Chang L, Deng J, Graham P, Kearsley J (2013). Combining low dose LBH589 A/Prof Yong Li with docetaxel increases apoptosis in epithelial ovarian cancer cells via PI3K/Akt /mTOR signalling pathway. IGCS, Associate Editor of World Journal of Cancer Research, Bali, Indonesia, 11-13 April 2013. USA (2012). Member, Epithelial-Mesenchymal Transition International Chang L, Wasinger V, Graham P, Hao JL, Ni J, Beretov J, Association (TEMTIA) 2013. Bucci J, Cozzi P, Kearsley J and Li Y (2013). Identification of Vice-president of the Australian Chinese Association novel biomarkers for prostate cancer radioresistance using of Chinese Biomedical Scientists (AACBS) 2013~ and the label-free LC-MS/MS approach. HUPO 12th Annual responsible for organizing the Annual meeting and World Congress, Yokohama, Japan, 14-18 September scientific meeting. 2013. Dr Julia Maclean Beretov J, Wasinger V, Schwartz P, Graham P, Millar E, Kearsley J and Li Y (2013). Proteomic investigation of Executive member, Australian and New Zealand Head and breast cancer biomarkers using human plasma and serum Neck Cancer Research Foundation samples. HUPO 12th Annual World Congress, Yokohama, Treasurer, Executive Australian and New Zealand Head and Japan, 14-18 September 2013. Neck Cancer Society.

Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley J and Li Y (2013). PI3K/Akt/mTOR dual inhibitors have obvious advantages over single inhibitors in overcoming prostate cancer radioresistance. AACR- Molecular Targets and Cancer Therapeutics, Boston, MA, USA, 19-23 Oct 2013.

Li Y, Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley J (2013). Prostate cancer radioresistance is associated with acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes via activation of the PI3K/Akt/mTOR pathway. The 6th EMT International Association (TEMTIA) Conference-Alicante, Spain, 13-16 Nov 2013.

Maclean, J.C., Ward EC., Findlay M, Rees G Dysphagia and nutritional management in Australian and New Zealand head and neck cancer centres , Dysphagia Research Society, Seattle, USA, March.

2013 - National

Ni J, Cozzi P, Hao JL, Beretov J, Chang L, Duan W, Delprado W, Graham P, Bucci J, Kearsley J and Li Y (2013). CD44 variant 6 is a biomarkers associated with prostate cancer metastasis and progression. The Lowy Cancer Symposium. UNSW, Sydney,May.

Chang L, Graham P, Hao JL, Ni J, Bucci J, Cozzi P, Kearsley J and Li Y (2013). Acquisition of epithelial-mesenchymal transition and cancer stem cell phenotypes is associated with activation of the PI3K/Akt/mTOR pathway in prostate cancer radioresistance. Prostate Cancer World Congress, Melbourne, 6-10 August.

80

SURGERY PERIOPERATIVE & ANAESTHETIC SERVICES

Anaesthesia St George Hospital > 83

Cardiothoracic Surgery > 85

Liver and Peritonectomy Surgery > 90

Orthopaedic Surgery > 96

Trauma > 104

Vascular Surgery > 108 > Department of Anaesthesia St George Hospital

Head of Department Michael Kerr MBBS FANZCA Andrew Kennedy MBBS FANZCA Richard Morris MBBS FANZCA Gerhard Labuschage MB ChB MMed(Anest) FCA(SA) Senior Medical- Staff Specialists FANZCA Harold Lam MBBS FANZCA Maggie Bailey BMBS FANZCA Lecturer Conjoint UNSW Mike Lambros MBBS FANZCA Chimene Bhar MBBS FRCA Ben Ma MBBS FANZCA Neil Bradburn MBBS FANZCA Lecturer Conjoint UNSW Bobby Manasiev MBBS FANZCA Peter Cox MBBS FANZCA Joanne Momsen MBBS FANZCA Marie Dreux BMBS FANZCA Lecturer Conjoint UNSW Gisele Mouret MBBS FANZCA Anthony Lewis PhD MB BCh FRCA FANZCA Jodi Murphy MBBS FANZCA Liz Mackson MBBS FANZCA Manu Narayanaswamy MBBS FANZCA Andrew Mcdonald MBBS FANZCA Neeraj Pal MBBS FANZCA Peter Nay MBBS FRCA FANZCA Pamela Salerno MBBS FANZCA She-yin Ng MBBS FANZCA Marianne Sidhom MBBS FANZCA Pauline Paton MBBS FANZCA Kate Smyth MBBS FANZCA Sharon Tivey MBBS FANZCA Lecturer Conjoint UNSW Vincent Sperando MBBS FANZCA Anica Vasic MBBS FANZCA Mark Steward MBBS FANZCA Abhijeet Tandel MBBS FANZCA Visiting Medical Officers Sue-Ann Wan MBBS FANZCA Andrew Armstrong MBBS FANZCA Lecturer Conjoint Helen Zois MBBS FANZCA UNSW Research Projects in Progress Erez Ben-Menachem MBBS FANZCA Philip Black BMBS FANZCA Enhanced oral intake prior to colonoscopy, G Peter Brennan MBBS FANZCA Labuschagne, M Kerr, T Holliday, R Morris. Colleen Bruce MBBS FANZCA Angela Brothers MBBS FANZCA Comparison of Prothrombinex vs Fresh Frozen Plasma Matthew Bruce MBBS FANZCA during Peritonectomy Surgery A Lewis, S Ho, D Morris, W Matthew Chiew MBBS FANZCA Liau Matthew Coady MBBS FANZCA Original Peer-Reviewed Publications Michael Cooper BMBS FANZCA Daniel Cox BMBS FANZCA Howe PW, Cooper MG. Blood loss and replacement for Vincent DaSilva MBBS FANZCA spring cranioplasty in Australia – a prospective national Cyrus De Souza MBBS FANZCA audit. Anaesthesia and Intensive Care 2012; 40: 107-113. Tamara Eichel MBBS FANZCA Robert Fabina MBBS FANZCA Santoro AS, Cooper MG, Cheng A. Failed intubation and Alex Fang MBBS FANZCA failed oxygenation in a child. Anaesthesia & Intensive Care Salwan Fransi MBBS FANZCA Lecturer Conjoint UNSW 2012:40: 1056-1058. David Goodie MBBS FANZCA Liao AY, Levin B, Daniel M, Chan L, Cooper MG, Birman Rajiv Gupta MBBS FANZCA CS. Emergency EXIT: an urgent ex utero intrapartum Andrew Guy MBBS FANZCA trachestomy for giant fetal neck mass. Aust NZ J Surgery Simon Harper MBBS FANZCA 2013; 83: 684-685. Drew Heffernan MBBS FANZCA Michael Henderson MBBS FANZCA Chatterjee DJ, Reid C, Lewis A. A potential technique for Robert Higgs MBBS FANZCA flexible scope-assisted intubation using an Ambu aScope Mark Higney MB ChB FRCA FANZCA 2TM inserted via a supraglottic airway device. Anaesthia Andrew Howard MBBS FANZCA and Intensive Care. 2012 July 40(4):724. Cameron Hunt MBBS FANZCA 83 Reid C, Lewis A, Habig K, Burns B, Billson F, Kunkel S, Fisk Cooper MG. Technology vs Tradition: How to get into W. Sustained life-like waveform capnography after human print. NSW Anaesthetic Continuing Education meeting, cadaveric tracheal intubation. Emergency Med J. 2013 Oct Australian & New Zealand College of Anaesthetists, 8. doi: 10.1136/emermed-2013-203105. [Epub ahead of Sydney, Jun 15, 2013. print]. Howard, A. Peri-operative Arrhythmias at Technology Presentations at Scientific Meetings and Meets Tradition, ANZCA and ASA 79th Continuing Conferences Education Seminar, Sydney, 15th June 2013.

2012 - International

Cooper MG. Pulse oximetry – Lifebox and a standard of care for anaesthesia and surgery in Papua New Guinea. Papua New Guinea Medical Symposium, Port Moresby, September 2012.

2013 - International

Lewis, A, Airway Management in Prehospital and Retrieval Medicine. Society of Anaesthetists of Wales Autumn Meeting. LLandrindod Wells, Wales, 7th November 2013

Lewis, A Simulation using Mobile Technology. Society of Anaesthetists of Wales Autumn Meeting. LLandrindod Wells, Wales, 7th November 2013

Lewis A, Richmond C. Sim Training. Cost effective ways to Train in your department. Developing Emergency Medicine, Havana, Cuba. 17th September 2013.

Lewis A, Richmond C. Train the Trainer Sim Training. Developing Emergency Medicine, Havana, Cuba. 17th September 2013.

2013 - National

ANZAC, Gallipoli, WW1. 8th International Symposium on the History of Anaesthesia, Sydney, Jan 2013. Graves M, Cooper MG. Anaesthesia at a Casualty Clearing Station: Review of an Australian Anaesthetists role in the Great War. 8th International Symposium on the History of Anaesthesia, Sydney, Jan 2013.

Cooper MG (speaker and chair). The challenges of paediatric anaesthesia in the developing world. Society of Paediatric Anaesthetists of Australia & New Zealand Annual Meeting, October 2013, Sydney.

84 > Department of Cardiothoracic Surgery

Head of Department controlled trials. J Thorac Cardiovasc Surg. 2013 Aug 146(2) 255-61. Dr Gary Fermanis MBBS (Hons) FRACS Cao C, Manganas C, Ang S, Yan, TD. A systematic review Visiting Medical Officers and meta-analysis on pulmonary resections by robotic Dr Con Manganas MBBS MS (NSW) FRACS video-assisted thoracic surgery. Annals of Cardiothoracic Dr Matthew Horton MBBS FRACS Surgery. 2012 May. 1 (1): 3-10. Dr Sheen Peeceeyen MCh Cao C, Manganas C, Ang S, Yan, TD. A meta-analysis Senior Research of unmatched and matched patients comparing video- assisted thoracoscopic lobectomy and conventional open Dr Christopher Cao MBBS, BSc (Med) lobectomy. Annals of Cardiothoracic Surgery. 2012 May. 1 (1): 16-23. Nursing Research Cao C, Manganas C, Bannon P, Vallely M, Yan TD. Drug- Patricia Newbon, RN eluting stents versus coronary artery bypass graft surgery Research Projects in Progress in left main coronary artery disease: A meta-analysis of early outcomes from randomized and nonrandomized Review of patients who have undergone pneumonectomy studies. J Thorac Cardiovasc Surg. 2013 Mar 145(3) 738- at St George Hospital 1992 - 2014, with a view to long 47. term outcomes. Dr A Kashani (Thesis). Farkouh ME, Domanski M, Sleeper LA, Siami FS, Original Peer-Reviewed Publications Dangas G, Mack M, Yang M, Cohen DJ, Rosenberg Y, Solomon SD, Desai AS, Gersh BJ, Magnuson EA, Lansky Cao C, Tian D, Manganas C, Matthews P, Yan TD. A, Boineau R, Weinberger J, Ramanathan K, Sousa Systematic review of trimodality therapy for patients with JE, Rankin J, Bhargava B, Buse J, Hueb W, Smith CR, malignant pleural mesothelioma. Ann Cardiothorac Surg. Muratov V, Bansilal S, King S 3rd, Bertrand M, Fuster V; 2012 Nov;1(4):428-37. FREEDOM Trial Investigators. Strategies for multivessel revascularization in patients with diabetes. N Engl J Med. Cao C, Indraratna SAP, Manganas C, Bannon P, Black 2012 Dec 20;367(25):2375-84. D, Yan T. D. Systematic Review and Meta-analysis of Transcatheter Aortic Valve Implantation versus Surgical Other Published Material Aortic Valve Replacement for Patients with Severe Aortic Stenosis. Ann Cardiothorac Surg. 2012 Nov 15. DOI: Cao C, Manganas C, Byrom M, Yan, T.D. Re: Radial 10.3978/j.issn.2225-319X.2012.11.09 artery or saphenous vein, a graft of second choice in coronary artery bypass surgery. J Thorac Cardiovasc Surg Cao C, Manganas C, Ang SC, Peeceeyen S, Yan TD. Apr;145(4):1147-8. Video-assisted thoracic surgery versus open thoracotomy for non-small cell lung cancer: a meta-analysis of Cao C, Manganas C, Indraratna P, Ang S, Yan T. Re: propensity score-matched patients. Interact Cardiovasc Transcatheter aortic valve implantation (TAVI): risky and Thorac Surg. 2013 Mar 16(3) 244-9. costly. BMJ 2012;345 e4710.

Cao C, Manganas C, Indraratna P, Ang S, Bannon P, Yan Cao C, Manganas C, Byrom M, Yan TD. Reply to the T. Cost-effectiveness of TAVI versus surgery for high-risk editor. J Thorac Cardiovasc Surg. 2013 Apr;145(4):1147-8. patients with aortic stenosis. J Am Coll Cardiol. 2013 Apr 23;61(16):1747-8.

Cao C, Manganas C, Horton M, Bannon P, Munkholm- Larsen S, Ang SC, Yan TD. Angiographic outcomes of radial artery versus saphenous vein in coronary artery bypass graft surgery: A meta-analysis of randomized 85 Presentations at Scientific Meetings and Meta-analysis of Propensity Score Matched Patients Conferences 7. Level 1A Evidence on Angiographic Outcomes of All presentations are by Dr Christopher Cao. Radial Artery versus Saphenous Vein in Coronary Artery Bypass Graft Surgery The 7th China Lung Cancer Minimally Invasive Therapy Forum/The 4th Asia-Pacific minimally Invasive Thoracic 8. A Systematic Review and Meta-analysis on Pulmonary Surgery Conference (Guangzhou, China; December 2013) Resections by Robotic Video-assisted Thoracic Surgery 1. XSOLA Study 9. Cross-sectional Study on Lobectomy Approach 2. Meta-analysis of Segmentectomy vs Lobectomy for (X-SOLA) Patients with NSCLC 10. Should Clopidogrel be Discontinued Prior to Coronary 15th World Conference on Lung Cancer (Sydney, Artery Bypass Graft Surgery for Patients with Acute Australia; October 2013) Coronary Syndrome?

1. Systematic Review of Pleurectomy in the Treatment of 11. Systematic Review of Trimodality Therapy for Patients Malignant Pleural Mesothelioma with Malignant Pleural Mesothelioma

2. A Meta-analysis of Extended Pleurectomy/ EuroPCRMeeting (Paris, France; May 2013): Decortication versus Extrapleural Pneumonectomy in the Treatment of Malignant Pleural Mesothelioma 1. TAVI versus Surgical Aortic Valve Replacement for Patients with Severe Aortic Stenosis 3. Video-assisted thoracic surgery versus open thoracotomy for non-small cell lung cancer - A meta- 2. Cost Analysis of TAVI – Can We Afford It? analysis of propensity score matched patients 20th Anniversary of VATS Lobectomy Consensus Meeting 4. A Systematic Review and Meta-analysis on Pulmonary (Edinburgh, UK; November 2012): Resections by Robotic Video-assisted Thoracic 1. VATS Lobectomy versus Open thoracotomy – A Surgery Systematic Review and Meta-analysis Propensity Score 5. Cross-sectional Study on Lobectomy Approach Matched Patients (X-SOLA) 2. Cross-sectional Study on Lobectomy Approach 6. Video-assisted Thoracoscopic Surgery at 20 Years: A (X-SOLA) Consensus Statement Cardiac Society of Australia and New Zealand Annual Cardiac Society of Australia and New Zealand Annual Scientific Meeting (Brisbane, Australia; August 2012): Scientific Meeting (Darwin, Australia; August 2013): 1. Drug-Eluting Stents versus Coronary Artery Bypass 1. A Systematic Review and Meta-analysis of Graft Surgery in Left Main Coronary Artery Disease - A Transcatheter Aortic Valve Implantation versus Meta-analysis of Randomized and Nonrandomized Surgical Aortic Valve Replacement for Patients with Studies Severe Aortic Stenosis (Baxter Young Achiever Award 2. Current Level IA Evidence for Radial Artery versus Winner) Saphenous Vein in Coronary Artery Graft Surgery – A 2. A Systematic Review of the Cost-effectiveness of Systematic Review and Meta-analysis of Randomized Transcatheter Aortic Valve Implantation Controlled Trials

3. A Meta-analysis of Drug-eluting Stents versus Royal Australasian College of Surgeons ASC (Kuala Coronary Artery Bypass Graft Surgery in Left Main Lumpur, Malaysia; May 2012): Coronary Artery Disease 1. Drug-Eluting Stents versus Coronary Artery Bypass 4. Systematic Review of Pleurectomy in the Treatment of Graft Surgery in Left Main Coronary Artery Disease - A Malignant Pleural Mesothelioma Meta-analysis of Randomized and Nonrandomized Studies 5. Video-assisted Thoracoscopic Surgery at 20 Years: A Consensus Statement 2. Current Level IA Evidence for Radial Artery versus Saphenous Vein in Coronary Artery Graft Surgery – A 6. Video-assisted Thoracic Surgery versus Open Systematic Review and Meta-analysis of Randomized Thoracotomy for Non-small Cell Lung Cancer – A Controlled Trials 86 3. Meta-analysis of VATS versus Open Thoracotomy for Early-Stage NSCLC

4. An Unusual Presentation of Recurrent Pneumonia (e-Poster).

87 > Department of Colorectal Surgery

Head of Department Dinning P, Wiklendt L, Gibbins I, Patton V, Bampton P, Lubowski DZ, Cook IJ, Arkwright J. Low-resolution colonic Assoc Professor David Lubowski FRACS manometry leads to a gross misinterpretation of the Senior Medical frequency and polarity of propagating sequences: Initial results from fibre-optic high-resolution manometry studies. Professor Denis King OAM FRACS Neurogastroenterol Motil 2013; 25(10): e64. Dr D Shevy Perera FRACS Dr Steven Gan FRACS Wang DH, Blenman N, Maunder S, Patton V, Arkwright J. Dr Daniel Kozman FRACS An optical fiber Bragg grating force sensor for monitoring sub-bandage pressure during compression therapy. Optics Junior Medical Express. 2013 Aug 26; 21(17):19799-807.

Dr Kim Phan-Thien FRACS Colorectal Fellow Presentations at Scientific Meetings and

Research Staff Conferences 2012 - International Vicki Patton RN Bsc(Health) MN(Hons) Sacral nerve stimulation workshop. Satellite Medtronic Original Peer-Reviewed Publications meeting at ASCRS meeting, San Antonio, USA, 2-3 June 2012 2012. “Sacral nerve stimulation: Clinical results” David Z. Lubowski. Lubowski DZ. Editorial. Colorectal surgery: rigour and logic when treating pelvic floor disorders. Editorial; International College of Surgeons, 38th Biennial World ANZJS 2012; 82:383-384 . Congress, Brisbane, Australia, 7-9 November 2012. “Sacral Nerve Stimulation for Faecal Incontinence” David Dinning PG, Hunt LM, Arkwright JW, Patton V, Szczesniak Z. Lubowski. MM, Wiklendt L,Davidson JB, Lubowski DZ, Cook IJ. Pancolonic motor response to subsensory and International Society University Colorectal Surgeons suprasensory sacral nerve stimulation in patients with slow- ISUCRS Biennial Congress XXV Bolongna Italy 24 transit constipation. British J Surg 2012; 99(7):1002-1110. June 2012. “Clinical characteristics of patients treated with sacral nerve stimulation for neurogenic faecal 2013 incontinence.” V Patton.

Wang S, McKay GD, Vonthethoff L, Lubowski DZ. Latent 2013 - International schistosomiasis triggering mesenteric panniculitis. ANZJS 2013; 83:396-397. American Society of Colon and Rectal Surgeons ASCRS meeting, Phoenix, 1 May 2013. Panel Symposium Lubowski DZ. Editorial. Multidisciplinary team meetings. on “Worst Cases”. “Cases on: Anal fistula” David Z. ANZJ Surg 2013; 83:99-100. Lubowski

Patton V, Wiklendt L, Arkwright JW, Lubowski DZ, New Zealand Medical Association, GP CME Meeting, Dinning PG.The effect of sacral nerve stimulation on distal Rotorua, 20 June 2013. “Management of anorectal colonic motility in patients with faecal incontinence. Br J conditions” David Z. Lubowski. Surg 2013; 100(7); 959-968 Mar 27. Combined Spring Meeting of Colorectal Surgical Society Diezmos EF, Sandow SL, Marcus L, Perera DS, Lubowski of Australia and NZ with Colon and Rectal Section of DZ, King DW, Bertrand PP, Liu L Expression and RACS, Gold Coast 11-13 July 2013. “Management of localization of pannexin-1 hemichannels in human colon constipation / internal rectal prolapse.” David Z. Lubowski in health and disease. Neurogastroenterol Motil 2013; 25, e395–e405.

88 2012 - National

UNSW Women’s Health and Research Institute of Australia, Sydney 4 Feb 2012. “Proctalgia and Proctalgia Fugax” David Z. Lubowski.

AGW , Adelaide, 18 October 2012. “Sacral nerve stimulation for colonic motility disorders – is it prime time?” David Z. Lubowski.

2013 - National

Annual Scientific Meeting Urogynaecological Society of Australasia, Sydney, 16 March 2013. “Management of post-defaecation soiling” David Z. Lubowski.

Pharmaceutical Society of Australia, Annual Meeting, Sydney 2 June 2013. “Modern management of anorectal conditions” David Z. Lubowski.

89 > Department of Liver and Peritonectomy Surgery

Head of Department Research Projects in Progress

Professor David Lawson Morris Pre-clinical evaluation of a novel nanoparticle, albumin- bound albendazole in the treatment of chemo-resistant Senior Medical ovarian cancer. Principal investigators: Mohammad Dr Jai Seema Bagia Pourgholami, Martina Stenzel, Lubna Noorani, Samina Badar, David Morris. Junior Medical Determination of the anticancer activity of monepantel Dr Nayef Alzahrani (Fellow – KSA Training Program) (AAD1566) in preclinical models of cancer. Principal Dr Saleh Alzahrani (Fellow – KSA Training Program) investigators: David Morris, Stephanie Chu, Samina Badar, Parvin Ataie-Kachoie, Mohammad Pourgholami. Research Staff Evaluation of minocycline as a potential drug for the Dr Mohammad Pourgholami, Principal Scientific Officer treatment of cancer-induced angiogenesis, metastasis MSc Pharmaceutical Sciences and PhD Pharmacology and malignant ascites formation. Principal investigators: Dr Jing Zhao, Hospital Scientist, M Med Sc Mohammad Pourgholami, Stephanie Chu, Samina Badar, Dr Javed Akhter, Technical Officer, MSc, PhD Parvin Ataie, David Morris. Dr Anahid Ehteda, Postdoc Research Fellow, UNSW BSc (Microbiology); MSc (Microbiology), PhD Role of human Sprouty proteins ovarian and breast cancers Dr Krishna Pillai, Research Assistant M Med Sc Principal investigators: Mohammad Pourgholami, Ahmed (Pharmaceutical Drug Development), Mekkawy, Samina Badar, Martina Stenzel, David Morris. Ms Stephanie Wai Ling Chu, Research Assistant, BSc (Hon); MSc Development of mucolytic comprising of bromelain and Mrs Samina Badar, Research Assistant MSc N-acetyl cysteine for the dissolution of mucin secreted Mrs Farnaz Bahrami-Budlalu, Postgraduate Research by pseudomyxoma peritonei, with enhanced efficacy by Student, Pharm D (Doctorate degree in Pharmacy), addition of other agents. Principal investigators: J.Akhter, Mrs Lubna Noorani, PhD student, UNSW M.Pharm. K.Pillai, A Ekheda and DL. Morris. Dr Afshin Amini, PhD student, MD Physio-chemical analysis of three grades of mucin Dr Samar Masoumi Moghaddam, PhD student, MD secreted by pseudomyxoma peritonei. Principal Dr Parvin Ataie-Kachoie, Research Officer, PharmAust Ltd investigators: K.Pillai, J.Akhter and DL. Morris. Pharm D (Doctorate degree in Pharmacy), PhD. Optimization of a mixture of bromelain and N-acetyl Research Grants cysteine for the treatment of malignant peritoneal mesothelioma. ARC project grant. Stenzel M, Morris DL, Pourgholami MH Principal investigators: K.Pillai, J.Akhter and DL. Morris. Targeted therapies using Sprouty proteins: Synthetic strategies to polyion complex micelles as smart nano-sized Combination of bromelain, N-acetyl cysteine and aspirin drug carriers for proteins (390,000.00 over 3 years 2014- for the treatment of malignant peritoneal mesothelioma. 2017). Principal investigators: K.Pillai, J.Akhter and DL. Morris.

ARC project grant Stenzel M, Morris DL, Pourgholami MH Anti-Tumour and Chemosensitising effect of a A platform for the efficient optimization of drug delivery combination of bromelain + N-acetylcystein with cytotoxic using cross-linked micelles and thioclick-chemistry toward drugs on cancer cells. Principal investigators: L. Pillai, better anti-cancer treatment. ($450,000.00 over 3 years J.Akhter and DL Morris. 2011-13). Comparison of three thermal tumour ablative devices such as monopolar, bipolar radiofrequency and microwave for their efficacy in the absence and in the presence of heat sink in perfused calf liver. Principal investigators: K.Pillai, J.Akhter and DL. Morris. 90 Tumour cell release dynamics during thermal ablation of Carcinomatosis: Cytoreductive Surgery and HIPEC–- liver tumours that involve the piercing of the surface of Overview and Basics. Cancer Investigation, 30(3), 209-224. tumours. Principal investigators: K.Pillai, J.Akhter and DL. Cao, C. Q., Yan, T. D., Deraco, M., Elias, D., Glehen, O., Morris. Levine, Sugarbaker, P. H. (2012). Importance of gender Pharmacokinetics of Monepantel in Mice. Principal in diffuse malignant peritoneal mesothelioma. Annals of investigators: A Ehteda, DL. Morris. Oncology, 23 (6), 1494-1498.

Combination therapy of Monepantel (AAD1566) with Cao, C. Q., Yan, T. D., Morris, D. L., Van der speeten, commonly used chemotherapeutic agents. Principal K., Laurberg, S., Glehen, O., Sugarbaker, P. H. (2012). investigators: DL. Morris, MH Pourgholami, Parvin Ataie- Prospective Registry On Mesothelioma Peritonei Kachoie. Treatment (PROMPT): study design and rationale.]. Tumori, 98(1), 166-171. Cytotoxic and mucolytic effects of bromelain in combination with N-acetylcysteine with potential value Chua, T. C., & Morris, D. L. (2012). Colorectal Liver in pseudomyxoma peritonei. Principal investigators: DL. Metastases with Extrahepatic Disease-A New Criteria for Morris, A Amini. Oncologic Resection? Journal of gastrointestinal cancer, 43(3), 502-504. Evaluation of the expression of human Sprouty proteins in epithelial ovarian cancer. Principal investigators: DL. Chua, T. C., & Morris, D. L. (2012). Exploring the role of Morris, S Masoumi Moghaddam. resection of extrahepatic metastases from hepatocellular carcinoma. Surgical Oncology, 21(2), 95-101. Original Peer-Reviewed Publications Chua, T. C., & Morris, D. L. (2012). Resectable Colorectal 2012 Liver Metastases: Optimal Sequencing of Chemotherapy. Journal of gastrointestinal cancer, 43(3), 496-498. Amini, A., Masoumi moghaddam, S., Morris, D. L., & Pourgholami, M. H. (2012). The Critical Role of Vascular Chua, T. C., & Morris, D. L. (2012). Therapeutic potential Endothelial GrowtFactor in Tumor Angiogenesis. Current of surgery for metastatic colorectal cancer. Scandinavian Cancer Drug Targets, 12(1), 23-43. Journal of Gastroenterology, 47(3), 258-268.

Amini, A., Masoumi moghaddam, S., Morris, D. Chua, T. C., Al-Alem, I., Zhao, J., Glenn, D. W., Liauw, L., & Pourgholami, M. H. (2012). Utility of vascular W., & Morris, D. L. (2012). Radiofrequency ablation of endothelial growth factor inhibitors in the treatment of concomitant and recurrent pulmonary metastases after ovarian cancer: from concept to application. Journal of surgery for colorectal liver metastases. Annals of Surgical Oncology, Volume 2012 (Article ID: 540791), 1-14. doi: Oncology, 19(1), 75-81. 10.1155/2012/540791. Chua, T. C., Chong, C. H., & Morris, D. L. (2012). Bahrami, F., Morris, D. L., & Pourgholami, M. H. (2012). Peritoneal Mesothelioma. Current Status and Future Tetracyclines: drugs with huge therapeutic potential. Mini- Directions. [10.1016/j.soc.2012.07.010]. Surgical Oncology Reviews in Medicinal Chemistry, 12(1), 44-52. Clinics of North America, 21(4), 635-643.

Bester, L., Meteling, B., Pocock, N. A., Pavlakis, N., Chua, Chua, T. C., Chong, C. H., Liauw, W. S., & Morris, D. L. T. C., Saxena, A., & Morris, D. L. (2012). Radioembolization (2012). Approach to Rectal Cancer Surgery. International versus Standard Care of Hepatic Metastases: Comparative Journal of Surgical Oncology, 2012 (Article ID: 247107), Retrospective Cohort Study of Survival Outcomes and 1-9. Adverse Events in Salvage Patients. Journal of Vascular and Interventional Radiology, 23(1), 96-105. Chua, T. C., Chong, C. H., Liauw, W. S., Zhao, J., & Morris, D. L. (2012). Inflammatory Markers in Blood and Brucher, B. L., Piso, P., Verwaal, V., Esquivel, J., Serum Tumor Markers Predict Survival in Patients With Derraco, M., Yonemura, Y, Nissan, A. (2012). Peritoneal Epithelial Appendiceal Neoplasms Undergoing Surgical

91 Cytoreduction and Intraperitoneal Chemotherapy. Annals efficacy in nude mice. Anticancer Research, 32(9), 3659- of Surgery, 256(2), 342-349. 3666.

Chua, T. C., Esquivel, J., Pelz, J. O., & Morris, D. L. (2012). Khan, A. B., Al-Suhaibani, Y., Al-Mohaimeed, K., & Morris, Summary of current therapeutic options for peritoneal D. L. (2012). Application of Advanced Multimodality Care metastases from colorectal cancer. Journal of Surgical to Pseudomyxoma Peritonei Patient: Report of First Patient Oncology, 107(6), 566-573. Treated at a Tertiary Center. Indian Journal of Surgical Oncology, 1(3), 270-273. Chua, T. C., Liauw, W. S., Chu, F., & Morris, D. L. (2012). Summary outcomes of two-stage resection for advanced Kim, Y., Liemmawal, E., Pourgholami, M. H., Morris, D. colorectal liver metastases. [10.1002/jso.23170]. Journal of L., & Stenzel, M. H. (2012). Comparison of shell-cross- Surgical Oncology, 107(2), 211-216. linked micelles with soft and glassy cores as a drug delivery vehicle for albendazole: Is there a difference in Chua, T. C., Liauw, W. S., Chu, F., & Morris, D. L. (2012). performance? Macromolecules, 45(13), 5451-5462. Viewing metastatic colorectal cancer as a curable chronic disease. American Journal of Clinical Oncology - Cancer Kim, Y., Pourgholami, M. H., Morris, D. L., & Stenzel, M. Clinical Trials, 35(1), 77-80. H. (2012). Effect of cross-linking on the performance of micelles as drug delivery carriers: a cell uptake study. Chua, T. C., Liauw, W. S., Zhao, J., & Morris, D. L. (2012). Biomacromolecules, 13(3), 814-825. Comparative analysis of perioperative intraperitoneal chemotherapy regimen in appendiceal and colorectal Klaver, Y., Chua, T. C., De hingh, I., & Morris, D. L. (2012). peritoneal carcinomatosis. International Journal of Clinical Outcomes of elderly patients undergoing cytoreductive Oncology. June 18(3) 439-46. surgery and perioperative intraperitoneal chemotherapy for colorectal cancer peritoneal carcinomatosis. Journal of Chua, T. C., Liauw, W., & Morris, D. L. (2012). Early Surgical Oncology, 105(2), 113-118. recurrence of pseudomyxoma peritonei following treatment failure of cytoreductive surgery and Masoumi moghaddam, S., Amini, A., Morris, D. L., & perioperative intraperitoneal chemotherapy is indicative Pourgholami, M. H. (2012). Significance of vascular of a poor survival outcome. International Journal of endothelial growth factor in growth and peritoneal Colorectal Disease, 27(3), 381-389. dissemination of ovarian cancer. Cancer and Metastasis Reviews, 31(1-2), 143-162. Chua, T. C., Moran, B. J., Sugarbaker, P. H., Levine, E., Glehen, O., Gilly, F. N., Morris, D. L. (2012). Early- Mekkawy, A. H., Morris, D. L., & Pourgholami, M. H. and Long-Term Outcome Data of Patients With (2012). HAX1 Augments Cell Proliferation, Migration, Pseudomyxoma Peritonei From Appendiceal Origin Adhesion, and Invasion Induced by Urokinase-Type Treated by a Strategy of Cytoreductive Surgery and Plasminogen Activator Receptor. Journal of Oncology, Hyperthermic Intraperitoneal Chemotherapy. Journal of 2012 (Article ID: 950749), 1-9. Clinical Oncology, 30(20), 2449-2456. Mirarabshahii, P., Pillai, K., Chua, T. C., Pourgholami, M. Chua, T. C., Pelz, J. O., & Morris, D. L. (2012). Surgery for H., & Morris, D. L. (2012). Diffuse malignant peritoneal colorectal peritoneal carcinomatosis. Scandinavian Journal mesothelioma - An update on treatment. Cancer of Gastroenterology, 47(3), 277-285. Treatment Reviews, 38(6), 605-612.

Chua, T. C., Saxena, A., Chu, F., & Morris, D. L. (2012). Ng, K. M., Chua, T. C., Saxena, A., Zhao, J., Chu, F., & Hepatic Resection for Transplantable Hepatocellular Morris, D. L. (2012). Two decades of experience with Carcinoma for Patients Within Milan and UCSF Criteria. hepatic cryotherapy for advanced colorectal metastases. American Journal of Clinical Oncology - Cancer Clinical Annals of Surgical Oncology, 19(4), 1276-1283. Trials, 35(2), 141-145. Pillai, K., Akhter, J., Chua, T. C., & Morris, D. L. (2012). Chua, T. C., Saxena, A., Liauw, W. S., Chu, F., & Morris, Mucolysis by Ascorbic Acid and Hydrogen Peroxide on D. L. (2012). Hepatectomy and resection of concomitant Compact Mucin Secreted in Pseudomyxoma Peritonei. extrahepatic disease for colorectal liver metastases - A [Journal of Surgical Research, 174(2), e69-e73. systematic review. European Journal of Cancer, 48(12), Pillai, K., Akhter, J., Chua, T. C., & Morris, D. L. (2012). 1757-1765. Potential mucolytic agents for mucinous ascites from Ehteda, A., Galettis, P. T., Chu, S. L. W., Pillai, K. R., & pseudomyxoma peritonei. Investigational New Drugs, Morris, D. L. (2012). Complexation of albendazole with 30(5), 2080-2086. hydroxypropyl-& #226;-cyclodextrin significantly improves its pharmacokinetic profile, cell cytotoxicity and antitumor

92 Pourgholami, M. H., Mekkawy, A. H., Badar, S., & Morris, Journal of Clinical Oncology - Cancer Clinical Trials. D. L. (2012). Minocycline inhibits growth of epithelial February, doi: 10.1097/COC.0b013e31827deea1. ovarian cancer. Gynecologic Oncology, 125(2), 433-440. Bester, L., Meteling, B., Pocock, N. A., Saxena, A., Chua, Saxena, A., Chua, T. C., Chu, F., Al-Zahrani, A., & Morris, T. C., & Morris, D. L. (2013). Radioembolisation with D. L. (2012). Optimizing the surgical effort in patients with Yttrium-90 microspheres: An effective treatment modality advanced American Journal of Clinical Oncology - Cancer for unresectable liver metastases. Journal of Medical Clinical Trials. Oct 35(5) 439-45. Imaging and Radiation Oncology, 57(1), 72-80.

Saxena, A., Chua, T. C., Perera, M., Chu, F., & Morris, D. Chan, D. L., Morris, D. L., & Chua, T. C. (2013). L. (2012). Surgical resection of hepatic metastases from Clinical efficacy and predictors of outcomes of repeat neuroendocrine neoplasms: A systematic review. Surgical hepatectomy for recurrent hepatocellular carcinoma – A Oncology, 21(3), e131-e141. systematic review. Surgical Oncology, 22(2), e23-e30.

Saxena, A., Chua, T. C., Zhao, J., & Morris, D. L. (2012). Chan, D. L., Morris, D. L., Chua, T. C., & Rao, A. (2013). Liver-directed therapy for neuroendocrine neoplasm Intraperitoneal chemotherapy in ovarian cancer: A review hepatic metastasis prolongs survival following progression of tolerance and efficacy. Cancer Management and after initial surgery. Journal of Surgical Oncology, 105(4), Research, 4(1), 413-422. 342-350. Chua, T. C., Quinn, L. E., Zhao, J., & Morris, D. L. Yang, T. X., Chua, T. C., & Morris, D. L. (2012). (2013). Iterative cytoreductive surgery and hyperthermic Radioembolization and chemoembolization for intraperitoneal chemotherapy for recurrent peritoneal unresectable neuroendocrine liver metastases - A metastases. Journal of Surgical Oncology, 108(2), 81-88. systematic review. Surgical Oncology, 21(4), 299-308. Ehteda, A., Galettis, P., Pillai, K., & Morris, D. L. (2013). 2013 Combination of Albendazole and 2-Methoxyestradiol significantly improves the survival of HCT-116 tumor- Al-Alem, I., Pillai, K., Akhter, J., Chua, T. C., & Morris, D. L. bearing nude mice. BMC Cancer, 13, Article number 86. (2013). Heat Sink Phenomenon of Bipolar and Monopolar Radiofrequency Ablation Observed Using Polypropylene Kim, Y., Pourgholami, M. H., Morris, D. L., Lu, H., & Tubes for Vessel Simulation. SurgicalInnovation. Oct 16 Stenzel, M. H. (2013). Effect of shell-crosslinking of 21(3) 269-76. micelles on endocytosis and exocytosis: acceleration of exocytosis by crosslinking. Biomaterials Science, 1, 265- Amini, A., Ehteda, A., Masoumi, S., Moghaddam, S. M., 275. Akhter, J., Pillai, K., & Morris, D. L. (2013). Cytotoxic effects of bromelain in human gastrointestinal carcinoma cell Klaver, Y. L., Chua, T. C., Verwaal, V., De hingh, I. H., & lines (MKN45, KATO-III, HT29-5F12, and HT29-5M21). Morris, D. L. (2013). Secondary cytoreductive surgery and OncoTargets and Therapy, 6, 403-409. peri-operative intraperitoneal chemotherapy for peritoneal recurrence of colorectal and appendiceal peritoneal Ataie-Kachoie, P., Badar, S., Morris, D. L., & Pourgholami, carcinomatosis following prior primary cytoreduction. M. H. (2013). Minocycline Targets the NF- B Nexus through Journal of Surgical Oncology, 107(6), 585-590. Suppression of TGF- 1-TAK1-I B Signaling in Ovarian Cancer. Molecular Cancer Research, 11(10), 1279-1291. Koh, J. L., Liauw, W., Chua, T., & Morris, D. L. (2013). Carbohydrate antigen 19-9 (CA 19-9) is an independent Ataie-kachoie, P., Morris, D. L., & Pourgholami, M. H. prognostic indicator in pseudomyxoma peritonei post (2013). Minocycline Suppresses Interleukine-6, Its Receptor cytoreductive surgery and perioperative intraperitoneal System and Signaling Pathways and Impairs Migration, chemotherapy. J Gastrointest Oncol, 4(2), 173-181. Invasion and Adhesion Capacity of Ovarian Cancer Cells: In Vitro and In Vivo Studies. PLoS ONE, 8(4), Article Moghaddam, S. M., Amini, A., Wei, A. Q., Pourgholami, number 60817. M. H., & Morris, D. L. (2013). Initial report on differential expression of sprouty proteins 1 and 2 in human epithelial Ataie-Kachoie, P., Pourgholami, M. H., & Morris, D. L. ovarian cancer cell lines. Journal of Oncology, 2012, (2013). Inhibition of the IL-6 signaling pathway: A strategy Article ID 373826. to combat chronic inflammatory diseases and cancer. Cytokine & Growth Factor Reviews, 24(2), 163-173. Morris, D. L. (2013). Peritonectomy HIPEC - Contemporary results, indications. Chinese Journal of Cancer Research, Bester, L., Feitelson, S., Milner, B., Chua, T. C., & Morris, D. 25(4), 373-374. L. (2013). Impact of prior hepatectomy on the safety and efficacy of radioembolization with Yttrium-90 microspheres Pillai, K., Akhter, J., Chua, T. C., & Morris, D. L. (2013). for patients with unresectable liver tumors. American Anticancer Property of Bromelain With Therapeutic 93 Potential in Malignant Peritoneal Mesothelioma. Cancer Williams, B. H. M., Alzahrani, N. A., Chan, D. L., Chua, T. Investigation, 31(4), 241-250. C., & Morris, D. L. (2013). Repeat cytoreductive surgery (CRS) for recurrent colorectal peritoneal metastases: Yes or Pillai, K., Pourgholami, M. H., Chua, T. C., & Morris, no? European Journal of Surgical Oncology (EJSO). doi: D. L. (2013). MUC1 as a Potential Target in Anticancer 10.1016/j.ejso.2013.10.022. Therapies. American Journal of Clinical Oncology, 1-1. doi: 10.1097/COC.0b013e31828f5a07. Yang, T. X., Billah, B., Morris, D. L., & Chua, T. C. (2013). Palliative resection of the primary tumour in patients with Pillai, K., Pourgholami, M. H., Chua, T. C., & Morris, D. Stage IV colorectal cancer: systematic review and meta- L. (2013). Ki67-BCL2 index in prognosis of malignant analysis of the early outcome after laparoscopic and open peritoneal mesothelioma. American Journal of Cancer colectomy. Colorectal Disease, 15(8), e407-e419. Research, 3(4), 411-423. Yang, T. X., Morris, D. L., & Chua, T. C. S. (2013). Pelvic Pillai, K., Pourgholami, M. H., Chua, T. C., & Morris, D. exenteration for rectal cancer: A systematic review. L. (2013). Does the expression of BCL2 have prognostic Diseases of the Colon and Rectum, 56(4), 519-531. significance in malignant peritoneal mesothelioma? American Journal of Cancer Research, 3(3), 312-322. Other Published Material

Pillai, K., Pourgholami, M. H., Chua, T. C., & Morris, D. Morris, DL (2013), Cytoreductive Surgery & Perioperative L. (2013). Oestrogen receptors are prognostic factors in Chemotherapy for Peritoneal Surface Malignancy. malignant peritoneal mesothelioma. Journal of Cancer Textbook and Video Atlas. PSOGI Group International. Research and Clinical Oncology, 139(6), 987-994. Contributing Author. Pillai, K., Pourgholami, M. H., Chua, T. C., & Morris, D. L. Presentations at Scientific Meetings and (2013). MUC1 has prognostic significance in malignant Conferences peritoneal mesothelioma. The International Journal of Biological Markers, 28(3), 303-312. 2012 - International

Pourgholami, M. H., Ataie-Kachoie, P., Badar, S., & Morris, Akhter J, Pillai K, Al-Alem I, & Morris D L (2012). D. L. (2013). Minocycline inhibits malignant ascites of Comparative study of radiofrequency ablation (RFA) ovarian cancer through targeting multiple signaling of a novel bipolar probe with a unipolar probe (in the pathways. Gynecologic Oncology, 129(1), 113-119. presence and absence of vessel simulation), using egg white and ex-vivo liver model. Paper presented at The Saxena, A., Chua, T. C., Fransi, S., Liauw, W., & Morris, Royal Australasian College of Surgeons Annual Scientific D. L. (2013). Effectiveness of early and aggressive Congress, Kuala Lumpur, Malaysia. administration of fresh frozen plasma to reduce massive blood transfusion during cytoreductive surgery. J Pillai K, Pourgholami MH, Akhter J, Chua TC, Morris DL Gastrointest Oncol, 4(1), 30-39. (2012). Ki67 is an important prognostic factor in malignant peritoneal mesothelioma. Poster presented at the Saxena, A., & Morris, D. L. (2013). Mortality and Peritoneal Cancer Symposium, Munich, Germany. Morbidity after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy for Peritoneal 2012 - National Carcinomatosis. Viszeralmedizin, 29(4), 6-6. Ataie-Kachoie P, Badar, S., Morris DL., Pourgholami Ung, L., Chua, T. C., & Morris, D. L. (2013). Cure for MH: Minocycline abolishes malignant ascites formation peritoneal metastases? An evidence-based review.. ANZ and tumor growth through attenuation of tumor Journal of Surgery, 83(11), 821-826. growth factor-ß, vascular endothelial growth factor and interleukin-6 pathways in an experimental model Ung, L., Chua, T. C., & Morris, D. L. (2013). Peritoneal of ovarian cancer. St. George and Sutherland Medical metastases of lower gastrointestinal tract origin: a Research Symposium, Sydney, October 2012. comparative study of patient outcomes following cytoreduction and intraperitoneal chemotherapy. Journal Bahrami F, Pourgholami MH, Morris DL: Monepantel of Cancer Research and Clinical Oncology, 139(11), 1899- suppress ovarian cancer cell proliferation by arresting 1908. G0-G1 cell cycle and down regulating related cyclins and Cdks proteins followed by inhibition of DNA incorporation. Ung, L., Chua, T. C., & Morris, D. L. (2013). Cure for St. George and Sutherland Medical Research Symposium peritoneal metastases? An evidence-based review. ANZ Sydney, October 2012. Journal of Surgery, 83(11), 821-826. Hossain L, Stenzel M, Pourgholami, MH, Morris DL: Albumin Nanoparticles for Delivery of Albendazole in 94 Ovarian Cancer: Uptake of Albendazole loaded Albumin Pillai K, Akhter J, Chua TC, Morris DL. A revolutionary Nanoparticles in Ovarian Cancer. Drug Delivery Australia, method for the treatment of pseudomyxoma peritonei. Melbourne, November 2012. St. George and Sutherland Medical Research Symposium, Sydney, October 2013. Mekkawy AB, Pourgholami MH, Morris DL: Suppression of growth factors-induced migration in human cells. St. Community Engagement George and Sutherland Medical Research Symposium Sydney, October 2012. Pourgholami MH – Member of Scientific Committee St George Medical Foundation. 2013 - International

Ataie-Kachoie, P., Morris, D. L., & Pourgholami, M. H. (2013/04/15/). Minocycline abrogates IL-6 signaling and inhibits migration, invasion and adhesion capacity of ovarian cancer cells. Paper presented at the 104th Annual Meeting of the American-Association-for-Cancer-Research (AACR), Washington, DC.

2013 - National

Amini, A., Moghaddam, S. M., Ehteda, A., & Morris, D. L. (2013). Cytotoxic effects of pineapple bromelain in gastrointestinal carcinoma cell lines. Paper presented at The 25th Lorne International Cancer Conference, Lorne, Australia.

Ataie-Kachoie P, Badar S., Morris DL., Pourgholami MH.: New implication for an old drug: minocycline as a potential candidate for ovarian cancer. The 25th Lorne International Cancer Conference, Lorne, Australia, February.

Ataie-Kachoie P, Badar, S., Morris DL., Pourgholami MH.: Minocycline down-regulates NF-BB-regulated cell proliferation, antiapoptotic and metastatic gene products through the suppression of NF-BB activation in ovarian cancer: in vitro and in vivo studies. St. George and Sutherland Medical Research Symposium. Sydney, October 2013.

Bahrami F, Morris DL, Pourgholami MH: Monepantel suppress ovarian cancer cell proliferation by arresting cell cycle at G1 and down regulating cyclins A, E, Cdk 2 and 4. The 25th Lorne International Cancer Conference, Lorne, Australia, February 2013.

Bahrami F, Morris DL, Pourgholami MH: Monepantel suppress ovarian cancer cell proliferation by arresting cell cycle at G1 through AMPK/ ERK / p70S6k pathway and down regulating cyclin D1, E, Cdk 4 and 2. St. George and Sutherland Medical Research Symposium, Sydney, October 2013.

Hossain L, Pourgholami MH, Liang R, Morris DL, Stenzel M: Delivery of albendazole for the treatment of ovarian cancer. Lowy Cancer Symposium, Sydney, May 2013.

Moghaddam, S. M., Amini, A., & Morris, D. L. (2013). Human epithelial ovarian cancer cell lines differentially express Sprouty proteins 1, 2 and 4. Paper presented at the 25th Lorne International Cancer Conference, Lorne, Australia. 95 > Department of Orthopaedic Surgery and Orthopaedic Research Institute

Head of Department Original Peer-Reviewed Publications

Dr Robert Molnar 2012

Senior Medical Xu Y,Bonar F,Murrell GA. (2012) Enhanced expression of neuronal proteins in idiopathic frozen shoulder. J Shoulder Professor George AC Murrell (Director, Orthopaedic Elbow Surg 21 1391-7. Research Institute) Dr Ashish Diwan Millar NL,Reilly JH,Kerr SC,Campbell AL,Little KJ,Leach Professor Ian Harris WJ,Rooney BP,Murrell GA,McInnes IB. (2012) Hypoxia: a Dr Hugh Jones critical regulator of early human tendinopathy. Ann Rheum Professor Ron Sekel Dis 71 (2) 302-10. Dr Wayne Viglione Dr Zoltan Szomor Walton JR,Murrell GAC. (2012) Effect of operative time on Dr S P Tan outcomes of rotator cuff repair. Tech Shoulder Elbow Surg Dr Michael Dixon 13 (1) 23-7. Dr Anthony Keeley Walton JR,Murrell GA. (2012) Clinical tests diagnostic for Junior Medical rotator cuff tear. Tech Shoulder Elbow Surg 13 (1) 17-22.

Dr Adrian Hughes Shepherd H,Murrell GAC. (2012) Use of synthetic patches Dr Edmund O’Leary as tendon substitutes in knotless arthroscopic repairs of Dr Alice Chang massive rotator cuff tears. Tech Shoulder Elbow Surg 13 (1) 32-5. Research Staff Le Lievre HMJ,Murrell GAC. (2012) Long-term outcomes A/Prof Judie Walton of arthroscopic capsular release for idiopathic adhesive Dr Ai Qun Wei capsulitis. J Bone Joint Surg (Am) (94) 1208-16. Dr Patrick Lam Dr Lijkele Beimers Peters K,McCallum S,Briggs L,Murrell GA. (2012) A Dr Aminudin Bin Mohammed Shamsudin comparison of the outcomes of arthroscopic repair of Dr P S Haen partial- versus full-thickness rotator cuff tears. J Bone Joint Dr Justine Naylor Surg (Am) 94 1078-85. Dr Pooria Sarrami Murrell GAC. (2012) Advances in rotator cuff repair - Ms Helen Badge undersurface repair. Tech Shoulder Elbow Surg 13 (1) 23-7. Ms Deanne Jenkin Ms Elizabeth Armstrong Bokhari AR,Murrell GA. (2012) The role of nitric oxide in Ms Deanne Jenkins tendon healing. J Shoulder Elbow Surg 21 (2) 238-44. Mr David Mijalkov Mr William du Moulin Kelly MJ,Andres B,Briggs L,Lam P,Ali R,Murrell GAC. (2012) Ultrasound-guided placement of a localization Research Grants wire for arthroscopic treatment of calcific tendonitis. Tech Shoulder Elbow Surg 13 (3) 134-7. HCF, Ian Harris, Improving services and outcomes for joint replacement patients, $705,000; 2013-2015 Millican J,Murrell GAC. (2012) Can handheld dynamometers diagnose partial-thickness rotator cuff Smith and Nephew (Investigator initiated), Dr Robert tears? Shoulder and Elbow 4 (2) 100-5. Molnar, Radiostereometric Analysis (RSA) of The Genesis II Minimally Invasive Surgery (MIS) Tibial Base Plate, $9000; Wu XL,Briggs L,Murrell GA. (2012) Intraoperative 2008 - 2014) determinants of rotator cuff repair integrity: an analysis of 500 consecutive repairs. Am J Sports Med 40 (12) 2771-6.

96 Walton JR,Murrell GAC. (2012) A two-year clinical Adie S, Dao A, Harris I A, Naylor J M, Mittal R, (2012) Sep outcomes study of 400 patients, comparing open surgery Satisfaction with joint replacement in public vs private and arthrosopic for rotator cuff repair. Bone Joint Res 1 hospitals: a cohort study, ANZ J Surg.;82(9): 616-624. 210-17. Arora M, Harris I A, McEvoy L, Mittal R, Naylor J M, (2012) Millar NL,Murrell GA. (2012) Heat shock protein in The effect of a single passive intervention to improve tendinopathy: novel molecular regulators. Mediators of patient satisfaction in an orthopaedic service Open Journal Inflammation (2012) (Article ID 436203) 1-7. of Orthopedics;2(2): 33.

Kishen TJ, Lindstrom ST, Etherington G, and Diwan AD Walton JR (2012) Evidence that ingested aluminum (2012). Veillonella spondylodiscitis in a healthy 76-year-old additives contained in processed foods and alum-treated lady. Eur Spine J.; 21 Suppl 4: 413-7. drinking water are a major risk factor for Alzheimer’s disease. Curr Inorg Chem 2, 19-33. Mitchell SJ, Hilmer SN, Kirkpatrick CM, Hansen RD, Williamson DA, Singh NA, Finnegan TP, Allen BJ, Diamond Walton JR (2012) Aluminum disruption of calcium TH, Diwan AD, Lloyd BD, Smith EU, and Fiatarone Singh homeostasis and signal transduction resembles change MA (2012). Estimation of lean body weight in older women that occurs in aging and Alzheimer’s disease. J Alzheimers with hip fracture. J Nutr Health Aging.; 16: 188-92. Dis 29, 255-273.

Molnar RB, Jenkin DE, Millar MJ, Campbell D, Walton JR (2012) Cognitive deterioration and assocoiated Harris IA Feb, (2012). The Australian arthroplasty pathology induced by chronic low-level aluminum thromboprophylaxis survey. J Arthroplasty, Feb 27(2):173- ingestion in a translational rat model provides an 9. explanation of Alzheimer’s disease, tests for susceptibility and avenues for treatment. Int J Alzheimers Dis, 91947, Hogg M, Molnar R, Shidiak L, Gillies M, May 1, (2012);. 17 pp doi:10.1155/2012/914947 (Open access). Comparison of a 3-Hole Locking Plate With Angled Screws to a Standard 4-Hole Hip Plate: A Finite Element 2013 Study. Journal of Bone & Joint Surgery, British Volume, Tham ERX,Briggs L,Murrell GAC. (2013) Ultrasound 94-B(SUPP XXIII):217. changes after rotator cuff repair - is supraspinatus tendon Small T, Cairns P, Proctor J, Molnar R. A, May 1, (2012) thickness related to pain? J Shoulder Elbow Surg 22 (8) Pilot Study to Assess a Multimodal Approach to Short e8-e15. Stay Arthoplasty. Journal of Bone & Joint Surgery, British Millar NL,Murrell GA,McInnes IB. (2013) Alarmins in Volume;94-B(SUPP XXIII):44. tendinopathy: unravelling new mechanisms in a common Molnar RB, Jenkin DE, Millar MJ, Campbell disease. Rheumatology (Oxford) 52 (5) 769-79. D, Harris IA Feb (2012),The Australian Ronquillo J,Lam P,Murrell GAC. (2013) Arthroscopic ePTFE Arthroplasty Thromboprophylaxis survey, Journal patch repair for irrepairable rotator cuff tears. Part 1: Arthroplasty;27(2):173-9. surgical technique and biomechanical comparison of two Gnanenthiran SR, Adie S, Harris IA, Feb (2012), suture techniques at the patch to tendon interface. Tech Nonoperative versus Operative Treatment for Shoulder Elbow Surg 14 (2) 29-32. Thoracolumbar Burst Fractures Without Neurologic Deficit: Ronquillo JC,Lam P,Murrell GAC. (2013) Arthroscopic A Meta-analysis Clin Orthop Relat Res.;470(2):567-77. ePTFE patch repair for irrepairable rotator cuff tears. Part Mitchell R, Watson WL, Curtis K, Harris I, McDougall P, 2: preliminary clinical results. Tech Shoulder Elbow Surg 14 (2012) Jan, Difficulties in establishing long-term trauma (2) 33-41. outcomes data collections. Could trauma outcomes Ronquillo J,Briggs L,Lam P,Murrell GAC. (2013) be routinely monitored in New South Wales, Australia: Morphological changes of synthetic (ePTFE) interpositional piloting a 3 month follow-up? Injury.;43(1):96-102. patch repair for massive irrepairable rotator cuff tear; a

97 short term prospective clinical study. Tech Shoulder Elbow Journal of Biomimetics, Biomaterials & Tissue Engineering. Surg 14 (3) 73-80. 2013; 13: 97-118.

McFarland EG,Maffulli N,Del Buono A,Murrell Mathew J, Singh S, Garis S, and Diwan A (2013). Backing GAC,Garzon-Muvdi J,Petersen SA. (2013) Impingement up the stories: The psychological and social cost of low is not impingement: the case for calling it “Rotator Cuff back pain. Int J Spine Surgery. 2013; 7: 29-38. Disease”. Muscles Ligaments Tendons J 3 (3) 196-200. Arora M, Diwan AD, Harris IA (2013). Burnout in Shepherd H,Lam P,Murrell GAC. (2013) Synthetic patch orthopaedic surgeons: a review. ANZ J Surg. 2013 Jul;83(7- rotator cuff repair- a 10-year follow-up. J Shoulder Elbow 8):512-5. Surg 6 (1) 35-9. Harris I A, Harris A M, Naylor J M, Adie S, Mittal R, Dao Murrell GA. (2013) Reply: measurement of posterior A T (2013), Discordance Between Patient and Surgeon capsule thickness. J Shoulder Elbow Surg 22 (8) e17. Satisfaction After Total Joint Arthroplasty Journal of Arthroplasty Volume 28, Issue 5, May 2013, Pages 722–727. Beimers L,Murrell GAC. (2013) Arthroscopic capsular release for idiopathic adhesive capsulitis - surgical Buhagiar MA, Naylor J M, Harris I A, Xuan W, Kohler F, technique. JBJS Essential Surgical Technique 3(1):e2. Wright R J and Fortunato R (2013), Hospital Inpatient versus Home-based rehabilitation after knee arthroplasty (The Bhattacharjee S, Zhao Y, Hill JM, Culicchia F, Kruck TPA, HIHO study): study protocol for a randomized controlled Percy ME, Pogue AI, Walton JR, Lukiw WJ (2013) Selective trial Trials 2013, 14:432. accumulation of aluminum in cerebral arteries in Alzheimer’s disease (AD). J Inorg Biochem 126, 35-37. Walton JR (2013) Aluminum’s involvement in the progression of Alzheimer’s disease. J Alzheimers Dis 35, Diwan AD, Leong A, Appleyard R, Bhargav D, Fang 7-43. (Open access) ZM, and Wei A (2013). Bone morphogenetic protein-7 accelerates fracture healing in osteoporotic rats. Indian J Presentations at Scientific Meetings and Orthop. 2013; 47: 540-6. Conferences

Oliver RA, Yu Y, Yee G, Low AK, Diwan AD, and Walsh 2012- International WR (2013). Poor histological healing of a femoral fracture following 12 months of oestrogen deficiency in rats. Murrell GAC, The 2nd International Symposium on Osteoporosis Int. 2013; 24: 2581-9. Musculoskeletal System and Pain, Sapporo, Japan. Lecture: Advances in the diagnosis and management of Arora M, Chan EK, Gupta S, and Diwan AD (2013). rotator cuff tears. Polymethylmethacrylate bone cements and additives: A review of the literature. World J Orthop. 2013; 4: 67-74. Murrell GAC, Funabashi Orthopaedic Sports Medicine Center, Funabashi, Japan; Department of Orthopaedic Arora M, Diwan AD, and Harris IA (2013). Burnout in Surgery, Tohoku University School of Medicine, Sendai, orthopaedic surgeons: a review. ANZ J Surg. 2013; 83: Japan. Lecture: Rotator cuff healing and repair. 512-5. Murrell G A C, 17th FINA World Sports Medicine Congress, Grigg M, Arora M, and Diwan AD (2013). Australian medical Istanbul, Turkey Lecture: Aetiology and Management of students and their choice of surgery as a career: a review. Shoulder Problems in Swimming Workshop: Shoulder ANZ J Surg. 2013. assessment.

Grigg M, Diwan AD (2013). The painful back; elements of Harris I A, American Academy of Orthopaedic Surgeons current understanding. Karnataka Medical Journal. 46:3-6. Annual Scientific Meeting, Tourniquet application only during cement fixation in total knee arthroplasty: a double- Arora M, Asha S, Chinnappa J, and Diwan AD (2013). blind randomized controlled trial Burnout in emergency medicine physicians. Emerg Med Pulsed electromagnetic field stimulation for acute Australasia. 2013; 25: 491-495. tibia fractures: a multicenter double blind randomized Chamoli U, Diwan AD, and Tsafnat N (2013). Pedicle screw- controlled trial. based posterior dynamic stabilizers for degenerative spine: Harris I A, AO Difficult Fracture Symposium – Korea, Timing In vitro biomechanical testing and clinical outcomes. J of surgery for hip fractures in the elderly Biomed Mater Res A. Epub Date 2014/01/03 Bisphosphonates: weighing the risks and benefits. Zhou F, Wei A, and Diwan A (2013). An overview of Peters K,Briggs L,Murrell GAC. (2012). Ultrasound-guided intervertebral disc degeneration and evaluation of the versus blind subacromial corticosteroid injection for chondrogenic and chemotactic potential of CDMP-2. 98 subacromial impingement. 2012 AAOS Annual Meeting, shoulders. Australian Orthopaedic Association Annual February 7-11, San Francisco, CA. Poster P315. Scientific Meeting, October 7-11, (2012), Sydney.

Wu X,Briggs L,Murrell GAC. (2012) Intra-operative Le Lievre HM,Murrell GAC. (2012) Long-term outcomes determinants of rotator cuff repair integrity: an analysis of arthroscopic capsular release for frozen shoulder. in 500 consecutive repairs. 2012 AAOS Annual Meeting, Australian Orthopaedic Association Annual Scientific February 7-11, San Francisco, CA. Paper 62. Meeting, October 7-11, Sydney.

Peters K,Murrell GAC. (2012) Permanent outperforms Peters K, Khoo J K, Wei A Q, Ronquillo J, Lam P, Murrell biodegradable anchors for arthroscopic stabilization. 2012 GAC. (2012) Permanent outperforms biodegradable AAOS Annual Meeting, February 7-11, San Francisco, CA. anchors for arthroscopic shoulder stabilization. Australian Paper 201. Orthopaedic Association Annual Scientific Meeting, October 7-11, 2012, Sydney. Dines J,Bedi A,Rodeo S,Murrell GAC. (2012) Biologic Augmentation of Tendon-Bone Healing in the 21st Beimers L,Lam P,Murrell GAC. (2012) The effects of Century: Where are we now? Instructional Course Lecture reinforcing rotator cuff repairs with ePTFE augmented 224. AAOS annual meeting, San Francisco, CA. sutures. 2012 Biennial Shoulder & Elbow Society of Australia, Brisbane, Queensland. Wu X,Briggs L,Murrell GAC. (2012) Intra-operative determinants of rotator cuff repair integrity: an analysis Shepherd H,Ronquillo J,Lam P,Murrell GAC. (2012) ePTFE in 500 consecutive repairs. AOSSM 2012 Specialty Day, patch repair for irrepairable rotator cuff tears. 2012 February 11, 2012, San Francisco, CA. Paper. Biennial Shoulder & Elbow Society of Australia, Brisbane, Queensland. Peters K,Murrell GAC. (2012) Permanent outperforms biodegradable anchors for arthroscopic stabilization. Open Lam P,Shepherd HM,Murrell GAC. (2012) Biomechanical Meeting of the American Shoulder and Elbow Surgeons, analysis of Fiber Tape versus Fiberwire in rotator cuff Specialty Day, February 11, 2012, San Francisco, CA. repair. The St George and Sutherland Hospital Medical Paper. Research Symposium, October 2012.

Le Lievre HM,Murrell GAC. (2012) Excellent long-term Khoo J,Wei AQ,Lam P,Ronquillo J,Murrell GAC. (2012) outcomes of arthroscopic capsular release for frozen Biomechanics and cytotoxicity of suture anchors used in shoulder. Open Meeting of the American Shoulder and labral repairs. The St George and Sutherland Hospital Elbow Surgeons, Specialty Day, February 11, 2012, San Medical Research Symposium, October 2012. Francisco. Paper. (Finalist Neer Award). Kroslak M,Murrell GAC. (2012) Surgical treatment of Tham L,Briggs L,Murrell GAC. (2012) Ultrasound changes lateral epicondylitis: a prospective., randomised, placebo after rotator cuff repair – is supraspinatus tendon thickness controlled pilot study. The St George and Sutherland related to pain? Orthopaedic Research Society 2012 Hospital Medical Research Symposium, October 2012. Annual Meeting in San Francisco, California, February 4-7. Lam PH,Hansen K,Keighley G,Briggs L,Murrell GAC. (2012) Poster. A randomised double blined clinical control trial evaluating Peters K,Murrell GAC. (2012) Permanent outperforms the effectiveness of daily vibration following arthroscopic biodegradable anchors for arthroscopic stabilization. 8th rotator cuff repair. The St George and Sutherland Hospital Biennial AAOS/ASES Shoulder and Elbow Meeting May Medical Research Symposium, October 2012. Poster. 3-5, 2012, Boca Raton Resort & Club, Boca Raton/Miami, Le BTN,Wu X,Lam PH,Murrell GAC. (2012) Factors Florida. Paper. predicting rotator cuff re-tear: An analysis of 1000 Dines J,Bedi A,Rodeo S,Murrell GAC. (2012) Biologic consecutive rotator cuff repairs. The St George and Augmentation of Tendon-Bone Healing in the 21st Sutherland Hospital Medical Research Symposium, Century: Where are we now? Instructional Course Lecture. October 2012, Poster. AAOS annual meeting, Chicago, IL. Tham L,Briggs L,Murrell GAC. (2012) Ultrasound changes 2012 - National after rotator cuff repair – is supraspinatus tendon thickness related to pain? The St George and Sutherland Hospital Murrell GAC, Lecture: Ultrasound and advances in rotator Medical Research Symposium, October 2012. Poster. cuff repair. Australian Sonographers Association Annual Meeting Canberra 2012. Shepherd HM,Lam PH,Murrell GAC. (2012) Interpositoin PTFE patch repair vs direct rotator cuff repair in an ovine Kurz AK, Kelly MJ, Briggs L,Murrell GAC (2012) Effect of model. The St George and Sutherland Hospital Medical surgeon-sonographer intaraction on ultrasound diagnosis Research Symposium, October 2012. Poster. of rotator cuff tears: a five-year cohort study in 775 99 Briggs L, Peters K, Murrell GAC. (2012) Ultrasound-guided Molnar R, Computer Navigated Total Hip Arthroplasty versus blind subacromial corticosteroid injection for - Can It Be Simple And Accurate? The Annual Scientific subacromial impingement. 4th International Compress on Meeting of the Arthroplasty Society, June (2012), Physical Activity and Public Health, Australian Conference Melbourne. of Science and Medicine in Sport, National Sports Injury Harris I A, ACI 2nd Annual Musculoskeletal Network Prevention Conference, Sydney. Journal of Science and Forum: Pre, peri and post-operative care in primary total Medicine in Sport, 15, 6, p 373. hip and knee replacement: a review of the evidence. Kurz A,Kelly M,Briggs L. Murrell GAC. (2012) Adrian Kurz: Sydney, 4 May 2012. Effect of surgeon-sonographer interaction on ultrasound Harris I A, NSW AOA Annual Scientific Meeting 2012: diagnosis of rotator cuff tears: A five-year cohort study Sydney 17 August 2012. in 775 shoulders. 4th International Compress on Physical Activity and Public Health, Australian Conference of • Complications and diagnostic investigations after hip Science and Medicine in Sport, National Sports Injury and knee arthroplasty in English proficient and non- Prevention Conference, Sydney. Journal of Science and English proficient patients Medicine in Sport, 15, 6, p 373. • Is centre-based care superior to a home program after Le B,Wu X,Murrell GAC (2012). Factors predicting rotator total knee replacement? A single blind randomized cuff re-tear rate: An analysis of 1000 consecutive rotator controlled trial cuff repairs. 4th International Compress on Physical Activity and Public Health, Australian Conference of • Why don’t people participate in randomized trials in Science and Medicine in Sport, National Sports Injury surgery? Prevention Conference, Sydney. Journal of Science and Mail versus telephone administration for Oxford hip Medicine in Sport, 15, 6, p 373. • and knee scores Lam PH, Hansen K, Keighley G, Briggs L,Murrell GAC. ANZ Hip Fracture Registry (2012) A randomised double blinded clinical control trial • evaluating the effectiveness of daily vibration following • The effect of a single passive intervention to improve arthroscopic rotator cuff repair. 4th International Compress patient satisfaction in an orthopaedic service on Physical Activity and Public Health, Australian Conference of Science and Medicine in Sport, National • Are subacute outcomes following TKR and THR Sports Injury Prevention Conference, Sydney. Journal of different in patients who have limited English Science and Medicine in Sport, 15, 6, p 374. proficiency?

Kroslak M,Murrell GAC. (2012) Surgical treatment of • Total hip replacement in haemodialysis and renal lateral epicondylitis: A prospective, randomised, blinded, transplant patients – a systematic review placebo controlled pilot study. 4th International Compress Dose dependent effects of intra-articular injection of on Physical Activity and Public Health, Australian • tranexamic acid on bleeding in total knee arthroplasty. Conference of Science and Medicine in Sport, National Sports Injury Prevention Conference, Sydney. Journal of Harris I A, AOA Annual Scientific Meeting: Sydney, 8-11 Science and Medicine in Sport, 15, 6, p 374. October 2012

Lam PH,Shepherd H,Murrell GAC (2012). Biomechanical • Rates of lumbar spine surgery, revision and mortality comparison of two arthroscopic rotator cuff repair rates for NSW, 2000-2008 techniques using synthetic scaffolds as a bridging device in an ovine model. 4th International Compress on Physical • Pulsed electromagnetic field stimulation for acute Activity and Public Health, Australian Conference of tibia fractures: a multicentre double blind randomised Science and Medicine in Sport, National Sports Injury controlled trial Prevention Conference, Sydney. Journal of Science and Trends in arthroscopic surgery and conversion to TKR: Medicine in Sport, 15, 6, p 157. • NSW 2000-2008 Leason S,Briggs L, Murrell GAC (2012) The effectiveness Predictors of discordance in patients and surgeon of ultrasound in diagnosis of adhesive capsulitis: A pilot • satisfaction after hip and knee replacement study. 4th International Compress on Physical Activity and Public Health, Australian Conference of Science • Is a 30 minute walk test useful after a knee and Medicine in Sport, National Sports Injury Prevention replacement? Conference, Sydney. Journal of Science and Medicine in Sport, 15, 6, p 158. • Why don’t people participate in randomized trials in surgery? 100 • The evidence base for common orthopaedic Harris I, 2nd Annual Whitlam Orthopaedic Research Centre procedures Symposium August 10, 2012, Liverpool Hospital NSW

• ANZ Hip Fracture Registry • Patient satisfaction after total joint replacement: private versus public • Total hip replacement in haemodialysis and renal transplant patients – a systematic review • Elective total hip and knee replacements: a review of the evidence • Spine surgery outcomes in a workers compensation environment • Patient preference for rehabilitation after joint replacements • Dose dependent effects of intra-articular injection of tranexamic acid on bleeding in total knee arthroplasty • Mail versus telephone administration for Oxford hip and knee scores • Peri-articular steroid injection in total knee arthroplasty: a prospective double blinded • The evidence base for common orthopaedic randomized controlled trial procedures Mortality after surgery in NSW.

• The CROSSBAT trial: lessons for conducting Harris I A, Australian Physiotherapy Association Annual multicentre randomized trials in orthopaedics in Meeting: Improving access to elective joint replacement Australia surgery: a waitlist cohort. Melbourne, October 2013.

• Are orthopaedic randomized trials generalisable? A Harris I A, Ingham Institute Annual Research and Teaching comparison with other surgical specialties Showcase: Sydney, November 2013

• Scientific and reporting quality of orthopaedic • Monitoring hip or knee arthritis: measurement error in randomized trials: a comparison with other surgical patient outcomes specialties • Tranexamic Acid to reduce blood transfusion in hip • Emergency pelvic fracture care: acute interventions fracture surgery are required in haemorrhagic shock (debate) • Inter-rater reliability in clinical registry data collection Harris I A, AOA Continuing Orthopaedic Education: Melbourne, 1-3 March 2013 • Accuracy and completeness data audit of the Arthroplasty Clinical Outcomes Registry • Orthopaedic Trauma: Distal radius fractures – internal fixation is rarely necessary • Opioid dependence after major orthopaedic trauma

• The CROSSBAT Trial: lessons learned from a • Opioid dependence after minor motor vehicle trauma. multicentre RCT. Harris I A, Osteoarthritis and viscosupplementation Harris I A, AOA Continuing Orthopaedic Education “Short- experts’ debate: The clinical evidence against Sharp” meeting - How I got into research: Sydney, 26 July viscosupplementation: Sydney, 27 June 2013 2013 Harris I A, Raising Expectations in Rheumatology, Surgical Harris I A, NSW AOA Annual Scientific Meeting: Sydney, recommendations – be wary: Melbourne, 28 July 2013. 23 August 2013 Harris I A, St George Hospital Osteoarthritis Symposium: ACORN: The Arthroplasty Clinical Outcomes Registry, • Over half of Australian orthopaedic trainees are NSW – what is it and why do we need it?, The clinical burned out: results from a nationwide cross-sectional evidence against injection therapy for osteoarthritis of the study knee, Kogarah. • Australian orthopaedic surgeons are highly satisfied Harris I A, SWSLHD Allied Health Research Forum, with their careers: results from a nationwide cross- Improving access to elective joint replacement surgery: a sectional study waitlist cohort. Liverpool NSW. • ACORN: The Arthroplasty Clinical Outcomes Registry, Harris I A, Western Orthopaedic Group of Surgeons NSW – what is it and why do we need it? Annual Meeting, The clinical evidence against injection • A comparison of alignment using patient specific therapy for osteoarthritis of the knee. Bowral, 30 instruments, computer navigation and conventional November 2013. instrumentation in total knee Arthroplasty.

101 Harris I A, Workers Compensation Conference, Spine of Shoulder and Elbow Surgery (ICSES 2013), Nagoya, surgery and injections: the case for restraint. Sydney, 24 Japan. Invited paper SSY-1-1. August 2013. Murrell GAC. Shepherd H,Ronquillo J,Lam P. (2013) 2013 - International ePTFE patch repair for irreparable rotator cuff tears. 12th International Congress of Shoulder and Elbow Surgery Murrell GAC, 12th International Congress of Shoulder (ICSES 2013), Nagoya, Japan. Paper SO-13-3. and Elbow Surgery (ICSES 2013), Nagoya, Japan. Lecture: Biological and synthetic patches for irreparable rotator cuff Murrell GAC, Peters K,Khoo J,Wei A,Ronquillo J,Lam tears. P. Permanent outperforms biodegradable anchors for arthroscopic stabilisation. 12th International Congress of Murrell GAC, 36th Annual Scientific Meeting Singapore Shoulder and Elbow Surgery (ICSES 2013), Nagoya, Japan. Orthopaedic Association, Singapore, 8-12 October 2013 Paper SO-14-9. Lecture: Permanent versus biodegradable anchors for arthroscopic stabilisation for traumatic anterior shoulder Arora M, Diwan AD, Harris IA; “Australian orthopaedic instability. Lecture: Rotator cuff tears - pathology and surgeons are highly satisfied with their careers: results from imaging. Lecture: Undersurface rotator cuff repair. a nationwide cross-sectional study”. Indian Orthopaedic Debate: Single row (*) versus double row for rotator Association Conference 2013 - Poster Presentation, India. cuff repair. Symposium: Rotator cuff repair with knotless Arora M, Diwan AD, et al; “PMMA bone cements system. Lecture: Biological and synthetic patches for and additives: A review of the literature”; 34th SICOT irreparable rotator cuff tears. Orthopaedic World Congress – Poster Presentation, India, Arora M, Diwan AD, Harris IA; “Burnout among Abstract number – 33557. orthopaedic surgeons”. Indian Orthopaedic Association Arora M, Diwan AD, et al; PMMA bone cements and Conference 2013 - Podium Presentation, India. additives: Review of literature”. 19th Asian Congress of Le BTN, Wu X, Lam PH, Murrell GAC. (2013) Factors Surgery and 1st Singhealth Surgical Congress 2013 – predicting rotator cuff re-tear: An analysis of 1000 Poster Presentation, Singapore. consecutive rotator cuff repairs. Open Meeting of the Briggs L,Lam P,Millar N,Murrell GAC. Are the symptoms American Shoulder and Elbow Surgeons, held on Specialty of calcific tendonitis due to neoinnervation and/or Day, Saturday, March 23, 2013, in Chicago, IL. neovascularisation? 2014 AAOS Annual Meeting, March Le BTN,Wu X,Lam PH,Murrell GAC. (2013) Factors 11-15, New Orleans, Louisiana, Paper 515. predicting rotator cuff re-tear: An analysis of 1000 Shamsudin A,Lam P,Murrell GAC. Primary versus revision consecutive rotator cuff repairs. AOSSM 2013 Specialty arthroscopic rotator cuff repair - an analysis in 350 Day, March 23, 2013, Chicago, IL. Paper 16. consecutive patients. 2014 AAOS Annual Meeting, March Peters K; Pirapakaran K Murrell GAC (2013) Permanent 11-15, New Orleans, Louisiana, Poster # P322. outperforms biodegradable anchors for arthroscopic Hawthorne J,Carpenter E,Lam P,Murrell GAC. Effect of shoulder stabilization. AOSSM 2013 Specialty Day, March glenohumeral abduction on supraspinatus repair tension. 23, 2013, Chicago, IL. Paper 12. 2014 AAOS Annual Meeting, March 11-15 in New Orleans, Kurz AK, Kelly MJ, Briggs L, Murrell GAC (2013) Surgeon- Louisiana, Poster # P315. sonographer interaction on ultrasound diagnosis of rotator Shamsudin A,Lam P,Murrell GAC. Primary versus revision cuff tears: Five-Year Study in 775 Shoulders. AAOS Annual arthroscopic rotator cuff repair - an analysis in 350 Meeting, March 19-23, Chicago, IL, paper 498. consecutive patients. 2014 AOSSM Specialty Day, March Le BTN,Wu X,Lam PH,Murrell GAC. (2013) Factors 11-15 in New Orleans, Louisiana, Paper. predicting rotator cuff re-tear: An analysis of 1000 Harris I A, AO Masters Course – Current Concepts consecutive rotator cuff repairs. AAOS Annual Meeting, Interprosthetic and Vancouver C fractures March 19-23, Chicago, IL, paper 122. History of pilon fractures Complex tibial plateau fractures Dines J,Bedi A,Rodeo S,Murrell GAC. (2013) Biologic and fracture-dislocations. Dubai, 28 September 2013. Augmentation of Tendon-Bone Healing in the 21st

Century: Where are we now? Instructional Course Lecture.

AAOS Annual Meeting, Chicago, IL.

Murrell GAC. (2013) Biological and synthetic patches for 2013 - National irreparable rotator cuff tears. 12th International Congress

102 Murrell GAC, Australian Sonographers Association Annual Meeting, Sydney. Plenary Lecture: Clinical assessment of shoulder and biomechanics, 2013, Sydney.

Arora M, Diwan AD, et al; “PMMA bone cements and additives: a review of the literature”; Australian Orthopaedic Association Annual Meeting 2013 - Poster Presentation, Australia.

Arora M, Diwan AD, Harris IA; “Australian orthopaedic surgeons are highly satisfied with their careers: results from a nationwide cross-sectional study”; Australian Orthopaedic Association Annual Meeting 2013 - Podium Presentation, Australia.

Arora M, Diwan AD, Harris IA; “Over half of Australian orthopaedic trainees are burned out: results from a nationwide cross-sectional study”; Australian Orthopaedic Association Annual Meeting 2013 - Podium Presentation, Australia.

Arora M, Diwan AD, Harris IA; “Australian orthopaedic surgeons are highly satisfied with their careers: results from a nationwide cross-sectional study”; New Zealand Orthopaedic Association Annual Meeting 2013 - Poster Presentation, New Zealand.

Arora M, Diwan AD, Harris IA; “Over half of Australian orthopaedic trainees are burned out: results from a nationwide cross-sectional study”; New Zealand Orthopaedic Association Annual Meeting 2013 - Poster Presentation, New Zealand.

Arora M, Diwan AD, Harris IA; “Australian orthopaedic surgeons are highly satisfied with their careers: results from a nationwide cross-sectional study”; Australian Orthopaedic Association NSW Branch Annual Meeting 2013 - Podium Presentation, Australia.

Arora M, Diwan AD, Harris IA ; “Over half of Australian orthopaedic trainees are burned out: results from a nationwide cross-sectional study”; Australian Orthopaedic Association NSW Branch Annual Meeting 2013 - Podium Presentation, Australia.

Community Engagement

Dr Ashish Diwan, Spinal Surgeon, Department of Orthopaedic Surgery, raised $140,000 donations for the UNSW foundation for spine research and education.

103 > Department of Trauma Services

Head of Department Day of Difference Foundation, Kate Curtis, Kim Foster, Rebecca Mitchell, Paediatric Critical Injury Research Dr Mary Langcake, FRACS, BMBS, BSc Program , $574,223, 2013-2018.

Senior Medical Research Projects in Progress Dr Christine Bowles, MBBS, FACEM Does the implementation of a Chest Injury protocol Dr Anthony Chambers, BSc, MBBS, MS, FRACS (ChIP) for patients with blunt thoracic trauma reduce Dr Anthony Morgan, MD, PhD complications and improve outcomes for patients? Nursing Kate Curtis, Stephen Asha, Annelise Unsworth & Mary Langcake. Kate Curtis, CNC, RN, MNurs (Hons), PhD Conjoint Associate Professor, February 2010 – June 2017 The CONFORM Study - PrediCtors Of analgesia use and St George Clinical School, University of NSW regimeN adherence FollOwing discharge after Major Honorary Professorial Fellow, June 2010 – June 2014 trauma. The George Institute for Global Health Helen Goldsmith, Kate Curtis & Andrea McCloughen. Visiting Associate Professor, May 2013 – May 2015 Exploring the Role of the Wound Care Clinical Nurse Faculty of Health Sciences and the Organisation and Consultant in a Tertiary Referral Hospital. Delivery of Care Research Group Matthew Dutton, Mary Chiarella & Kate Curtis. University of Southampton, England Taneal Wiseman, CNC Evaluation of an emergency nursing assessment framework Belinda Kennedy, CNS on patient assessment and documentation: A feasibility Liz Walter, CNS pilot. Sarah Kourouche, CNS Belinda Munroe, Kate Curtis & Thomas Buckley. Jane Leroi, RN Belinda Munroe, CNS Life threatening injury in young people: A mixed methods study. Research Grants Rebekah Ogilvie, Kim Foster, Kate Curtis, Andrea McCloughen. Motor Accidents Authority of NSW, NSW Small Grants round. Kate Curtis, Lynne Roberts, Mary Langcake. Depression, Anxiety and Stress in Major trauma patients Improving the care and outcomes of patients with blunt Taneal Wiseman, Kate Curtis &Kim Foster . chest injury. $14,814, 2013-14. What makes an Emergency Nurse? Personality Types/ Motor Accidents Authority of NSW, NSW Small Grants characteristics . round. Kate Curtis, Helen Goldsmith, Mary Langcake. Belinda Kennedy, Kate Curtis & Donna Waters. Improving outpatient pain management. The profile rural trauma presentations. $13, 676, 2013-14. Maryanne Sewell & Kate Curtis. Motor Accidents Authority of NSW, NSW Small Grants The impact of trauma nursing roles on patient outcomes round. Taneal Wiseman, Kate Curtis, Sandra West. Liz Walter & Kate Curtis. E-learning to improve trauma care on the wards. $14, 717, 2013-14. Cost of Major Trauma in NSW. University of Sydney: Nursing, Health Sciences, UNSW TARS, The George Emergency Care Institute, Kate Curtis, Margaret Murphy, Institute for Global Health, NSW Institute of Trauma and Jennifer Hardy, Melinda Lewis, Luke Strachan & Tom Injury Management. Buckley. HiRAID: Evaluation of an emergency nursing Kate Curtis, Deborah Black, Doris Lam, Rebecca Mitchell & assessment framework on patient assessment and John Myburgh. documentation: A pilot study, $99,457, 2012-14.

104 The scribe nurse in major trauma: Does level of experience Taylor C, Jan S, Curtis K, Tzannes A, Li Q, Palmer C & improve quality of documentation and leadership? Myburgh J (2012). The cost-effectiveness of physician Kate Curtis, Alana Clements, Leanne Horvat & Ramon staffed Helicopter Emergency Medical Service (HEMS) Shaban. transport to a major trauma centre in NSW, Australia. Injury, 43; 1843–1849 Subdural Haemmorrhage in older persons: a comparison of outcomes between those on anticoagulants at the time Dutton M & Curtis K (2012). Well-wound therapy: use of injury and those not. Stephen Asha, Jaenette Keady, of NPWT to prevent laparotomy breakdown. Journal of Kate Curtis & Saeed Kohan. Wound Care, 21(8);386-8

Integrative Literature review on successful models of care Willenberg L, Curtis K, Taylor C, Jan S, Glass P, Myburgh delivery for severely injured children. Kate Curtis, Kim J (2012). The variation of acute treatment costs of trauma Foster, Rebecca Mitchell. in high-income countries. BMC Health Services Research, 12(1):267 The incidence of paediatric trauma in Australia. Kate Curtis, Kim Foster, Rebecca Mitchell. Curtis K, Mitchell R.J, Chong S.S, Balogh Z.J, Reed D.J, Clark P.T, D’Amours S, Black D.A, Langcake M.E, Taylor What are the levels of emotional distress, contributing C.J, McDougall P.A, Cameron P.A (2012). Injury trends factors and unmet needs of parents of injured children and mortality in severely injured adults in NSW. Medical throughout the trauma journey? Kate Curtis, Kim Foster, Journal of Australia, 197(4): 233-237 Rebecca Mitchell. Clements A & Curtis K (2012). What is impact of nursing How is care provided for paediatric trauma patients and roles in hospital patient resuscitation? Australasian their families? Kate Curtis, Kim Foster, Rebecca Mitchell. Emergency Nursing Journal, 15(2): 108-115.

What are the needs of parents of severely injured children Mitchell R, Curtis K, Fisher M (2012). Understanding in Australia? Kate Curtis, Kim Foster, Rebecca Mitchell. trauma as a men’s health issue: gender differences in Improving outcomes in children suffering major trauma traumatic injury presentations at a level 1 trauma centre in Kate Curtis, Kim Foster, Rebecca Mitchell. Australia. Journal of Trauma Nursing, 19(2), 80-88.

Original Peer-Reviewed Publications Curtis K, Caldwell E, Delprado A, Munroe B (2012). Traumatic Injury in Australia and New Zealand. Australasian 2012 Emergency Nursing Journal, 15(1); 45-54.

Asha SE, Curtis KA, Taylor C, Kwok A. Patient-controlled Frydenberg E, Curtis K, Chong S, Poulos R, Grzebieta R, analgesia compared with interval analgesic dosing Steel T, Nau T (2012). Road Trauma, patterns of injury and for reducing complications in blunt thoracic trauma: a mortality in an Australian trauma centre. Journal of the retrospective cohort study. Emergency Medicine Journal, Australasian College of Road Safety, 23(1):21-28. 2012. doi:10.1136/emermed-2012-201980 Asha S, Curtis KA, Grant N, Taylor C, Lo S, Smart R, et Curtis K, Leonard E: The Trauma Nurse Coordinator in al (2012). Comparison of radiation exposure of trauma Australia and New Zealand: Demographics, Role and patients from diagnostic radiology procedures before and Professional Development. Journal of Trauma Nursing after the introduction of a panscan protocol. Emergency 2012, 19(4):214-220. Medicine Australasia. 24(1):43-51

Ogilvie R, Foster K, McCloughen A & Curtis K. The Mitchell R, Watson W, Curtis K, Harris I & McDougall experience of surviving life-threatening injury: a qualitative P (2012). Difficulties in establishing long-term trauma synthesis. International Nursing Review, 2012, 59(3):312- outcomes data collections. Could trauma outcomes 320. be routinely monitored in New South Wales, Australia: piloting a 3 month follow-up? Injury, 43(1): 96-102.

105 2013 Malaysia

Wiseman T, Foster K & Curtis K. Mental health following Langcake M, Invited Speaker. Training Teams for Trauma, traumatic physical injury: an Integrative literature review. Surgical Education Program. RACS 81st Annual Scientific Injury. 2013;44(11):1383-1390 Congress, 10 May 2012, Malaysia.

Taylor C, Curtis K, Jan S & Newcombe M. Helicopter Langcake M, Invited Speaker. The Problems with Total Emergency Medical Services (HEMS) over-triage and the Body Scans, Trauma Surgical Program. RACS 81st Annual financial implications for major trauma centres in NSW, Scientific Congress, 10 May 2012, Malaysia. Australia. BMC Emergency Medicine June 2013, 13:11 2012 National Curtis K, Chan D, Lam M, Mitchell R, King K, Leonard Dutton M, Chiarella M & Curtis K. The current state of L, D’Amours S, Black D. The profile and cost of major knowledge into role, context of practice and impact of trauma in older people in New South Wales, Australia. the wound care nurse. 10th National Australian Wound Australasian Journal on Ageing (online June 2013 DOI: Management Association Conference. Sydney Convention 10.1111/ajag.12059) & Exhibition Centre18 -21 March. Mitchell R, Curtis K, Holland AJ, Balogh ZJ, Evans, J, Clements A, Curtis K, Holzhauser K, Horvat L. The Wilson K (2013). Acute costs and predictors of higher impact of a senior nurse as nurse team leader on treatment costs for major paediatric trauma in New communication and perceptions of leadership in major South Wales, Australia. Journal of Paediatrics and Child. trauma resuscitations. 10th International Conference for 49(7):557-63 Emergency Nursing, 10-12th October, Hobart. Munroe B, Curtis K, Considine J, Buckley T. The Impact Curtis K, Mitchell R.J, Chong S, Balogh Z.J et al. Injury Structured Patient Assessment Frameworks Have on trends and mortality in adult patients with major trauma in Patient Care: An Integrative Review. Journal of Clinical New South Wales, Australia, AMDIG 2012 Unlocking the Nursing (2013 Early online DOI: 10.1111/jocn.12226) Value of Mortality Data Workshop. 13 November, Sydney. McIntosh AS, Curtis K, Rankin T, Cox M, Pang TY, McCrory Curtis K, Mitchell R.J, Chong S, Balogh Z.J et al. Injury P & Finch C. Associations between helmet use and brain trends and mortality in adult patients with major trauma injuries amongst injured pedal- and motor-cyclists: A case in NSW, 10th International Conference for Emergency series analysis of trauma centre presentations. Journal of Nursing, 10-12th October, Hobart . the Australasian College of Road Safety 2013; 24, 11-20. Munroe B, Curtis K, Buckley T, Considine J. The impact of Dinh M, Curtis K, Ivers R. The effectiveness of helmets a structured patient assessment on patients and clinicians. in reducing head injuries and hospital treatment costs in 10th International Conference for Emergency Nursing, 10- Sydney, Australia. A multicentre study. Medical Journal of 12th October, Hobart. Australia 2013; 198 (8): 415-417 Curtis K, Lam M, Mitchell R, Black D et al. Acute costs and Mitchell R, Curtis K, Chong S, Holland AJ, Soundappan predictors of higher treatment costs of trauma in New SVS, Wilson KL, Cass DT. Comparative analysis of trends South Wales, Australia. Trauma 2012, 26-28th October, in paediatric trauma outcomes in Australia. Injury, 2013, Perth. 44:97-103.

Presentations at Scientific Meetings and Leonard E, Curtis K. A snapshot: Resources currently available in trauma services throughout Australia and New Conferences Zealand. Trauma 2012, 26-28th October, Perth. 2012 International Curtis K, Leonard L. Australian and New Zealand Trauma Dutton M, Chiarella M & Curtis K (2012). The current state Nurse Coordinators. Who, what and where? Trauma 2012, of knowledge into role, context of practice and impact of 26-28th October, Perth. the wound care nurse. 4th Congress of the World Union Clements A, Curtis K, Holzhauser K, Horvat L. The impact of Wound Healing Societies Better Care, Better Life, of a senior nurse as nurse team leader on communication September 2-6, Yokohama Japan and perceptions of leadership in major trauma Frydenberg E, Curtis K, Chong S, Poulos R, Grzebieta R, resuscitations. Trauma 2012, 26-28th October, Perth. Steel T, Nau T (2012). Road Trauma, Patterns of Injury and Curtis K, Mitchell R.J, Chong S, Balogh Z.J et al. Injury Mortality in an Australian Trauma Centre. Neurosurgery trends and mortality in adult patients with major trauma in Section of the Royal Australasian College of Surgeons’ NSW. Trauma 2012, 26-28th October, Perth. Annual Scientific Congress., 7 – 10 May Kuala Lumpur, 106 Curtis K, Invited Speaker. Panel member for moderated Curtis K, Invited Speaker: Critical aspects of trauma discussion entitled ‘2012 Vision, Challenges, and New nursing care 8th Annual Critical Care Conference in the Frontiers in Emergency Care’ Panel 10th International Vineyards, 9 - 10th May. Conference for Emergency Nursing, 10-12th October, Curtis K, Invited Speaker: Trauma nursing innovations 8th Hobart. Chaired by Jane Hutcheon. Annual Critical Care Conference in the Vineyards, 9 - 10th Curtis K, Invited Speaker: Swan XX Trauma Conference, May. Sydney, NSW. July 28-29th 2012 . Community Engagement Langcake M, Panel Session “Dealing with Uncertainty”. Whole Person Care 2nd National Symposium. Doltone Langcake M, Teaching on EMST/DSTC. Senior Surgery House, Sydney. 21 March 2012. Program. RACS 81st Annual Scientific Congress, Malaysia. 7 May 2012. Langcake M, Invited speaker Gunshot Wounds Energy Transfer. SWAN XX Trauma Conference, Sydney, NSW. 28 Langcake M, Invited Speaker: Consequences of Trauma in July 2012. Older Patients. Seniors’ Day Injury Prevention Seminar, St George Leagues Club 21 March 2012. 2013 International Langcake M, Probus Club of Revesby. 24 September 2012. Chan D, Curtis K, et al. The injury profile and acute treatment costs of major trauma in older people in New Langcake M Consequences of Trauma in Older Patients. South Wales” E-Poster Presentation. Trauma Surgery Seniors’ Day Injury Prevention Seminar, St George Leagues Section of the Royal Australasian College of Surgeons Club. 21 March 2013. Annual Scientific Congress, 6 – 10 May 2013, Auckland, Langcake M Consequences of Trauma in Older Patients. New Zealand. The Sutherland Hospital’s Clinical Grand Rounds. 29 April Crouch R, Palfrey R, McHale H, Curtis K. Trauma Nurse 2013. Coordinators in England, Major Trauma Coordinator Langcake M Experiences in Afghanistan. Probus Club of National Conference, Salford, England, 25th November Ryde. 28 May 2013. 2013. Wiseman T, Pedestrian Trauma. Seniors Day Injury 2013 National Prevention Seminar, 20 March 2013, Mortdale, NSW. Langcake M, Invited Speaker: Inspiring Women in Hosted by Trauma Services, St George Hospital. Medicine. Women in Medicine, Parkville 12 August.

Ogilvie R, Curtis K, Palmer C, Lam M, McCloughen A, Foster K. Incidence and outcomes of major traumatic injury in the Australian Capital Territory. Canberra Health Annual Research Meeting (CHARM). 20-23rd August.

Kennedy B, Curtis K, Waters D. The Personality Characteristics of Emergency Nurses. International Conference for Emergency Nurses, 9-12 October, Melbourne.

Ogilvie R, Curtis K, Palmer C, Lam M, McCloughen A, Foster K. Incidence and outcomes of major traumatic injury in the Australian Capital Territory. International Conference for Emergency Nurses, 9-12 October, Melbourne.

Mitchell R, Curtis K et al. Acute care costs and predictors of higher treatment costs for major paediatric trauma in NSW. 11th Australasian Injury Prevention & Safety Promotion Conference, 11-13 November Fremantle, Western Australia.

Curtis K, Invited Speaker: Management of massive haemorrhage in trauma. International Conference for Emergency Nurses, 9-12 October 2013, Melbourne.

107 > Department of Vascular Surgery

Head of Department

Dr Eric Farmer MBBS(Hons) FRACS DDY

Visiting Medical Officers

Dr K Hanel MB BS FRACS DDU Dr L Lemech MB BS FRACS DDU Dr G McMullin MB BS FRACS DDU A/Prof J Iliopoulos MB BS (Hons1) FRACS (Cardiothoracic and vascular) PhD

Vascular Trainee

Michael Tawadrous, Fellow Victor Bourke, Vascular SET 3 trainee Adrian Tchen, Vascular SET 1 trainee Jill O’Donnell, Fellow Tam Nguyen, Vascular SET 5 trainee Saissan Rajendran, Vascular SET 1 trainee

Research Projects in Progress

Prospective evaluation of a model to predict outcomes following Endovascular Aortic Aneurysm Repair. Chief Investigator Associate Professor Robert Fitridge, The Queen Elizabeth Hospital, Adelaide, South Australia. St George Principal Investigator L.D. Lemech.

Managing trauma in the austere environment: a project for special operations command of the Australian Army. J. Iliopoulos, Chief Investigator; Prof W R Walsh (S & ORL NSW).

Adhesions in lumbar spine surgery. J Iliopoulos, Chief investigator Prof. WR Walsh (S&ORL UNSW), (Ongoing).

Training of defence force staff in simple tissue handling procedures in a sheep carcus model, J Iliopoulos, Chief Investigator Prof W R Walsh (S & ORL UNSW).

Renal Dysfunction in patients undergoing Endoluminal grafting of Abdominal Aortic Aneurysms. Principle Inestigator – Taranei Amir-Nizami.

108 MENTAL HEALTH

Mental Health Academic Unit / School Of > 110 Psychiatry > Mental Health Academic Unit / School Of Psychiatry

Head of Department Dr Herng Nieng Chan (visiting psychiatrist) Dr Montserrat Porter (visiting academic) Dr Kevin Clarke MBBS(Hons),MHA, Grad Dip FBS, Dr Phern Chern Tor (visiting psychiatrist) FRANZCP, Conjoint Lecturer UNSW Senior Research Staff Senior Medical Dr Angelo Alonzo (BA, BSc (Hons), Ph.D) Professor Colleen Loo (MB.BS. (Hons), FRANZCP, MD. Dr Donel Martin (MClinNeuroPsych; Ph.D; BA (Hons)) School of Psychiatry UNSW; Research Psychiatrist – Black Dog Institute Research Staff Dr Matthew Boulton, BMBS BSc FRANZCP, Conjoint Dr Veronica Galvez-Ortiz (MBBS, MD, Ph.D) Associate Lecturer UNSW Dr Bronwyn Hegarty (Ph.D) Dr Anne Camac, MBBS, FRANZCP, Conjoint Lecturer Stevan Nikolin (BSc) UNSW Natalie Katalinic (BA (Hons)) Dr Mesut Cetiner, MBBS Bsc (Med) (Hons) FRANZCP, Certificate POA & Conjoint Lecturer UNSW Research Students Dr Denise Cupina MD, FRANZCP, Conjoint Senior Lecturer UNSW Michael Player (BPsych (Hons), Ph.D) Dr Spencer Duke, BMedSci BM BS MRCPsych FRANZCP, Kerrie-Anne Ho (BPsych (Hons), Ph.D) Conjoint Senior Lecturer UNSW Emily O’Keefe (Medical student, independent learning Dr Andrew Gerard, MBBS FRANZCP project) Dr Yana Kay, MBBS, BA, PHD FRANZCP, Conjoint Lecturer UNSW Research Grants Dr Andrew Pethebridge, MBBS, MM (Ven Sci), MM, NHMRC Project Grant ID 1004152 – Role of neurogenesis FRANZCP, FAChAM, Conjoint Senior Lecturer UNSW in clinical recovery from depression during ECT: Dr Margot Phillips, BABSc (Med) MBBS FRANZCP Application of a novel in vivo magnetic resonance Dr Anne Wand, Staff Specialist Psychiatrist, Clinical spectroscopy technology. Dr Michael Valenzuela, Professor Lecturer, USYD, Conjoint Senior Lecturer UNSW Colleen Loo, Dr Jesus Pujol, Professor Petar Djuric, Dr Dr Carmelo Aquilina MD FRCPsych FRANZCP, Senior Dennis Velakoulis, Associate Professor Murat Yucel, Clincial Lecturer, USYD Professor Mike Dragunow. $505,312 (2011-2013) Dr Kylie GullifordBSc(Hons) MBBS(Hons) FRANZCP Advanced Certificate Child Psychiatry Child & Adolescent NARSAD young Investigator Award – Remediation of Psychiatrist Conjoint Lecturer UNSW cognitive dysfunction in euthymic bipolar disorder patients Dr Sam Harvey, Consultant Psychiatrist & Clinical using transcranial direct current stimulation (tDCS), Dr Academic, Consultation Liaison Psychiatry Team Lecturer Donel Martin. $60,000 USD (2011-2012) UNSW Dr Aparna Menon MBBS FRANZCP Dementia Collaborative Research Centre grant. Staff Specialist Senior Conjoint Lecturer UNSW Mental Transcranial direct current stimulation (tDCS) to enhance Health Rehabilitation Unit, The Sutherland Hospital outcomes from computer facilitated cognitive training in patients with mild cognitive impairment (MCI). Principal Vocational registrars, advanced trainees Investigator Mohan A. Associate Investigators Martin D, Sachdev P, Brodaty H, Loo C, Gates N. $40,000. 2012. Dr Rosalyn Lai (MBBS, MD) Dr Laura Cotiga (MBBS, MD) Stanley Medical Research Foundation. A Controlled Trial Dr Alison Bautovich (MBBS, MD) of Transcranial Direct Current Stimulation as a Treatment for Unipolar and Bipolar Depression. 11T-005. Loo C. Visiting fellows $681,595 USD (2012-2015) Dr Patricia Sanchez-Paez (visiting academic) UK MRC/NHS Efficacy and Mechanism Evaluation grant. Dr Pablo Puras (visiting academic) Ketamine augmentation of electroconvulsive therapy 110 to improve outcomes in depression. Anderson et al. Research Projects in Progress £1,002,385 [Note non UK CIs not permitted. Therefore Prof Colleen Loo is named as an international expert Principal Investigator: Professor Colleen Loo (all studies adviser on the grant] (2012) below)

NHMRC Program Grant ID: 1037196.“Depressive and Genetic Factors, Biomarkers and Outcomes of Brain bipolar disorders: Pathophysiology, phenotypes and Stimulation treatment innovations.” Principal investigator Mitchell P, An investigation of the effects of trancranial electrical Schofield P, Parker G, Breakspear M. $7100525. (2013- stimulation 2017). Open pilot trial of temporal lobe transcranial direct current NHMRC Project Grant ID 1051423. Electrical Stimulation stimulation (tDCS) for depression with a “Random Noise” Pattern: A New Approach for the Treatment of Depression. Principal Investigators Loo C, Neuroplasticity induced by transcranial direct current Mitchell P, Taylor I. $505 380. (2013-2015) stimulation treatment.

UNSW Major Research Equipment & Infrastructure Grant. A pilot study of ketamine as an antidepressant Near Infrared Spectrosopcy. Loo C, Sachdev P, Mitchell P, Dokos. $ 44,213. 2012. Investigating direct current stimulation as a treatment for depression: A controlled clinical trial St George Medical Research Foundation Establishment Grant. Does transcranial DirectCurrent Stimulation A controlled trial of transcranial direct current stimulation (tDCS) enhance outcomes from computerised cognitive as a treatment for unipolar and bipolar depression remediation inpatients with schizophrenia? – A randomised Electrical Stimulation with a “Random Noise” Pattern: A controlled trial in a rehabilitatory setting. Menon A, Loo C, Novel Approach for the Treatment of Depression Martin D, Bowman A. $17,000.. 2012. A comparison of transcranial electrical stimulation methods RANZCP New Investigator Grant. Does transcranial DirectCurrent Stimulation (tDCS) enhance outcomes Anaesthesia in ECT Study from computerised cognitive remediation inpatients A study of transcranial electrical stimulation (TES) as a with schizophrenia? – A randomised controlled trial in a maintenance treatment for depression. rehabilitatory setting. Menon A. $5882. 2012. Trial of Bilateral Transcranial Direct Current Stimulation NSW Institute of Psychiatry Research Fellowship, 0.5 FTE. (tDCS) for the treatment of depression A study of ketamine as an antidepressant treatment. Lai R. $55,000, 2012. Low frequency rTMS: A randomized trial

Pfizer Neuroscience Research Grant. A comparative Assessment of Suitability for Participation in Research Trials Study of Intravenous, Intramuscular and subcutaneous Administration of Ketamine in Depression. Lai R. $40,000, The effect of repeated and intermittent sessions of 2013. transcranial electrical stimulation on cortical excitability

NSW Institute of Psychiatry Research Fellowship, 0.6 Enhancing verbal learning and memory using high FTE. Treating depression in hemodialysis patients: a definition transcranial direct current stimulation (HD-tDCS) randomised sham controlled trial of transcranial Direct Remediation of cognitive dysfunction in euthymic Current Stimulation (tDCS). Bautovich A. $73 494.30 2013. bipolar disorder patients using transcranial direct current RANZCP New Investigator Grant.Treating depression in stimulation (tDCS): A pilot study hemodialysis patients: a randomised sham controlled trial Transcranial direct current stimulation (tDCS) to enhance of transcranial Direct Current Stimulation (tDCS). Bautovich outcomes from computer facilitated cognitive training in A. $6000, 2013. patients with mild cognitive impairment (MCI) 111 Original Peer-Reviewed Publications Bai S, Loo C, Dokos S. Effects of electroconvulsive therapy stimulus pulsewidth and amplitude computed 2012 with an anatomically-realistic head model. In: Conference Proceedings IEEE Engineering in Medicine and Biology Bai S, Loo C, Dokos S. A computational model of direct Society, 2012; p. 2559-2562. brain excitation induced by electroconvulsive therapy: comparison among three conventional electrode 2013 placements. Brain Stimulation 2012; 5(3): 408-421. Loo C, Garfield J, Katalinic N, Schweitzer I, Hadzi-Pavlovic Galvez V, Alonzo A, Martin D, Loo C. Transcranial direct D. Speed of Response in Ultrabrief and Brief Pulse Width current stimulation (tDCS) treatment protocols. Should Right Unilateral ECT. Int J Neuropsychopharmacology stimulus intensity be constant or incremental over multiple 2013; 16: 755-761. sessions? Int J Neuropsychopharmacology 2012; 16(1): 13-21. Loo C. ECT in the 21st Century: Ultrabrief pulse stimulation – a new development in treatment technique. Loo C, Alonzo A, Martin D, Mitchell P, Galvez V, Sachdev Australian Prescriber 2013; 36(1) 22-23. P. Transcranial direct current stimulation for depression: 3-week, randomised, sham-controlled trial. British Journal Perich T., Mitchell, P.B., Loo, C., Hadzi-Pavlovic, D., of Psychiatry 2012; 200:52-59. Roberts, G., Lau, P., Wright, A., Frankland, A. Clinical and demographic features associated with the detection of Loo C, Katalinic N, Martin D, Schweitzer I. A review early warning signs in bipolar disorder, Journal of Affective of ultrabrief pulse width electroconvulsive therapy. Disorders 2013; 145(3): 336-340. doi.org/10.1016/j. Therapeutic Advances in Chronic Disease 2012; 3(2) 69-83. jad.2012.08.014.

Smith D, Schweitzer, I, Ingram, N, Loo, C. Successful Martin D, Alonzo A, Ho, K-A, Player M, Mitchell P, Ultrabrief ECT for a Mixed Episode of Bipolar Disorder. Sachdev P & Loo C. Continuation transcranial direct Australian & New Zealand J Psychiatry, 2012; 46: no. 4 388 current stimulation for the prevention of relapse in major doi: 10.1177/0004867411433954 Letter/ case report. depression. Journal of Affective Disorders 2013; 144: 274- 278. Kalu, U, Sexton C, Loo C, Ebmeier K. Transcranial Direct Current Stimulation in the Treatment of Major Depression: Chan H, Alonzo A, Martin D, Mitchell P, Sachdev P, Loo A Meta-Analysis. Psychological Medicine 2012; 42(9): C. Augmenting transcranial direct current stimulation with 1791-1800. doi:10.1017/S0033291711003059 D-cycloserine for depression: A pilot study. J ECT 2013; 29(3):196-200. Chan, H, Alonzo A, Martin D, Player M, Mitchell P, Sachdev P, Loo C. Treatment of major depressive disorder by Cupina D, Patil S, Loo C. Chronic catatonic schizophrenia transcranial Random Noise Stimulation: Case report of a treated successfully with right unilateral ultrabrief pulse novel treatment. Biological Psychiatry 2012; 72(4): e9-e10 electroconvulsive therapy: A case report. J ECT 2013; PMID: 22425412. 29(2); 134-136.

Player, M, Taylor J, Alonzo A, Loo C. Paired associative Rae C, Lee V, Ordidge R, Alonzo A, Loo C. Anodal stimulation increases motor cortex excitability more transcranial direct current stimulation increases brain effectively than theta-burst stimulation. Clinical pH and modulates bioenergetics. International J Neurophysiology 2012; 123(11):2220-6. Neuropsychopharmacology, 2013; 16(8); 1695-1706.

Loo C & Martin D. Could transcranial direct current Bai S, Loo C, Dokos S. A review of computational models stimulation have unexpected additional benefits in the of transcranial electrical stimulation. Critical Reviews in treatment of depressed patients? Expert Review of Biomedical Engineering. 2013;41(1):21-35. Neurotherapeutics. 2012: 12 (7): 751-753. Alonzo A, Chan G, Martin D, Mitchell P, Loo C. Transcranial Loo C, Katalinic N, Garfield J, Sainsbury K, Hadzi-Pavlovic Direct Current Stimulation (tDCS) for Depression: Analysis D, MacPherson R. Neuropsychological and mood effects of Response Using a Three-Factor Structure of the of ketamine in electroconvulsive therapy: A randomised Montgomery-Åsberg Depression Rating Scale. J Affective controlled trial. J Affective Disorders 2012; 142(1-3): 233- Disorders, 2013; 150(1); 91-95. 240. Faculty of 1000 Recommended. Katalinic, N, Lai R, Somogyi, A, Mitchell P, Glue P, Loo CK. Chan H, Mitchell P, Loo CK & Harvey S. Treatment resistant Ketamine as a new treatment for depression: A review of depression: Pharmacological approaches. Medical Journal its efficacy and adverse effects. Australian & New Zealand of Australia 2012; 1(Supp 4); 44-47. J Psychiatry, 2013; 47(8); 710-727.

112 Galvez, V, Loo C, Alonzo A, Cerrillo E, Menchon J, Crespo ECT and Neurostimulation. Barossa Valley, 1 Sept, 2012. J, Urretavizcaya M. Do benzodiazepines moderate the Invited main speaker, Queensland Neuropsychiatry effectiveness of bitemporal Electroconvulsive Therapy in Interest Group, “Neurostimulation Forum”. 27th Oct 2012. Major Depression? J Affective Disorders 2013; 150(2):686- Brisbane. 690. doi: 10.1016/j.jad.2013.03.028). ECT workshop, Royal Melbourne Hospital, 14 Nov 2012. Martin D, Liu R, Alonzo A, Green M, Player M, Sachdev P, Loo C. Can transcranial direct current stimulation Session Chair, Health Service Alliance First Annual enhance outcomes from cognitive training? A Scientific Symposium.“Science and Health for Women in randomized controlled trial in healthy participants. Int J 2012”.Royal Hospital for Women, Sydney.15 Nov, 2012. Neuropsychopharmacology 2013; 16(9):1927-1936. 2013 - International Player M, Taylor J, Weickert C, Alonzo A, Sachdev P, Martin D, Mitchell P, Loo CK. Neuroplasticity in Invited plenary speaker. “RUL ultrabrief ECT: further Depressed Individuals Compared to Healthy Controls. RCT evidence”. International Society for ECT and Neuropsychopharmacology 2013; 38(11):2101-2108 Neurostimulation. San Francisco. 19 May 2013.

Corry J, Green M, Roberts G, Frankland A, Wright A, Lau 2013 - National P, Perich T, Loo C, Breakspear M, Mitchell P. Anxiety, stress NSW Official Visitors Program-Training Day. “Treatment and perfectionism in bipolar disorder. J Affective Disorders Approaches in Electroconvulsive Therapy”.1 9 February, 2013; 151(3):1016-1024. 2013. Sydney. Martin D, Katalinic N, Ingram A, Schweitzer I, Smith Invited speaker, Professorial Grand Rounds, Westmead D, Hadzi-Pavlovic D, Loo C. A new early cognitive Hospital. “Brain Stimulation: A New Tool in Psychiatry”. 4 screening measure to detect cognitive side-effects of July 2013. electroconvulsive therapy? J Psychiatric Research 2013; 47(12):1967-1974. Invited speaker, Health-E-Care Hospitals Planning weekend. “New Directions in Research”. 13-14 July 2013. Presentations at Scientific Meetings and Byron Bay, NSW. Conferences Invited Speaker, The Melbourne Clinic. “Multicentre RCT All presentations listed are by Professor Colleen Loo of Ultrabrief pulse ECT”. Melbourne, 24 July 2013. 2012 - International Plenary Speaker “Transcranial Direct Current Stimulation”. International Society for ECT and Neurostimulation Australian Brain Stimulation conference, Melbourne, Annual Meeting.“Transcranial Direct Current Stimulation”. Australia. 25-26 July, 2013. Symposiumpresenter.Philadephia, US. 6 May, 2012. St George Hospital Grand Rounds. “ Neuroplasticity in Presentation to Neuroscience Research Unit, University of health and psychiatric illness”. 5 Sept 2013. Manchester, “Transcranial Direct Current Stimulation: A Concord Centre for Mental Health. “Application of Brain New Treatment for Depression?” 11 May, 2012. Stimulation in Psychiatry”. 19 September 2013. 2012 - National Invited speaker, RANZCP Neuropsychiatry and Behavioural NSW Official Visitors Program-Training Day. Neurology Conference 8 - 9 November 2013. The “Electroconvulsive Therapy”. 9 February, 2012. Sydney Melbourne Brain Centre, University of Melbourne. “ECT: A Constantly Evolving Science”. RANZCP Invited symposium speaker: tDCS. Hobart, May 2012. Speaker “Brain Stimulation is Good for You: ECT & tDCS”. UNSW Brain Sciences Colloquium. Black Dog Institute, 25 Specialist Mental Health Services for Older People November 2013. Benchmarking Forum, NSW Health. Guest Speaker – presentation on ECT.NSW Mental Health Drug and Invited Speaker, VIC Chief Psychiatrist’s Clinical Practice Alcohol Head Office, Sydney. 5 June, 2012. Forum: ECT. 3 Dec 2014, Melbourne. [Note all Vic psychiatrists were invited to attend a special ½ day Invited main speaker, Ramsay Healthcare Continuing forum, convened to discuss ECT policy and practice in Education Workshop on “ECT and TMS”, Adelaide Clinic, the state of Vic. C Loo was the invited speaker and panel SA, August, 2012. discussant, to provide expert input into this forum.]

Invited main speaker, SA NeurostimulationRetreat.Talks on Keynote speaker, ASPR, Melbourne 4-6 Dec 2013. 113 Community Engagement Ketamine Benefits Depression Patients, says Study TopNews 7/6/12 Television Ketamine ‘could relieve depression’, Ninemsn 7/6/12 and The Project – Special Report, “Going Global: Bulletin Wire, 7/6/12 electroconvulsive therapy”, 12/6/12 Ketamine may relieve depression, trials show, Australian “Ketamine” – ABC Catalyst, 25/10/12 Doctor, 7/6/12 tDCS in depression – Channel 9 National News 6pm, Party drug ‘special k’ may help relieve depression, The 9/2/13. Australian Also published on Silobreaker, Topix NewKerala News ECT – Insight program. SBS. 24/9/13. Track India (Web India 123 Yahoo! Lifestyle India, Big News Radio Network, The Times of India India4u, Jagran Post, The Free Library, Hamara News, AndhraNews.net 7/6/12 Interview-ABC Radio Darwin, on ECT, 19/12/12 Depression trial using Ketamine looking for volunteers, Interview about ECT. ABC Radio (WA). 6/3/13. MedIndia.

Interview – Radio Australia, on ECT and tDCS, 6/4/13. Common anesthetic discovered to be providing instant Print Media relief to depression sufferers.,TopNews Arab Emirates, 7/06/12 “Brainwave is a breakthrough”. St George and Sutherland Shire Leader. 6/3/12 “’Special’ drug set to ease the blues”, Adelaide Advertiser, 8/6/12. “Shock Value” – Sydney Morning Herald, article about ECT. 10/11/12 “Special K eases blues”, MX Brisbane, 7/6/12.

Promising Depression Treatment – article about tDCS in “A quiet revolution”, UNSW Uniken (http://uniken.unsw. depression New York Times 11/2/13. edu.au/features/quiet-revolution), 7/6/12. tDCS in depression. The Globe and Mail, Vancouver. “Ketamine could play anti-depressant role”, India Pharma Interviewed 14/2/13. News (http://www.contify.com/story/ketamine-could-play- anti-depressant-role-9041055), 9/6/12 “Lite and easy, Nurse Ratched. Electroconvulsive shock therapy not like it used to be” & “Going with the Current” Party drug treats depression, Sydney Morning Herald, Also Australian Financial Review. 6/3/13. published in Warren Advocate Casey Weekly), Hobsons Bay Weekly 19/6/12. Brain cells slower to adapt with depression” Sydney Morning Herald. 1/6/13 Australian researchers test speedy depression drug, Psychiatry Update 22/6/12 “Warning over gamer’s headset”. DIY tDCS. Sun Herald. 30/6/13. Special K for Depression Renews Hope in Hallucinogens, Bloomberg Also published in The Frostproof News The Web Media Lake Wales News, The Polk County Democrat, The Fort Meade Leader 08/7/12-10/7/12 New depression treatment ‘safe and effective’, News Medical Special K: ketamine’s road from tranquiliser to possible antidepressant, The Conversation 13/12/12 Electrical stimulation of the brain is a safe treatment for depression The Conversation Depressed brains are less plastic. ABC Science. 28/5/13

Safe And Effective New Treatment For Depression MediLexiton 9/3/12

’ Special K’ could relieve depression Daily Telegraph UNSW Newsroom Virtual Medical Centre Also published on Sky News, Courier Mail, Medical Xpress Herald Sun, All Voices, News.com.au, Interceder, Bigpond News, Perth Now, Adelaide Now, Arizona Health between 6/6/12 - 7/6/12

114 WOMEN’S AND CHILDREN’S HEALTH

Urogynaecology > 116

Women’s Health > 119 > Department of Urogynaecology

Head of Department Mansfield (University of Wollongong), Y Cheng, V Gebski (University of Sydney) Professor KH Moore MBBS MD FRCOG FRANZCOG CU Development of novel techniques for identification of Senior Medical intracellular bacteria in human urothelial cells Y Cheng, Dr E Karantanis MBBS FRANZCOG MD CU K Mansfield (University of Wollongong, KH Moore M Schembri (University of Queensland). Junior Medical Original Peer-Reviewed Publications Dr N Te West Dr Z Chen 2012

Research Staff Shahab RB, Sarma S, Moore KH, Kuteesa WMA, Cebola M, Walsh CA, Wang YA, Karantanis E. Randomized Dr Ying Chen – Laboratory Scientist Controlled Trial of Cough Test versus no Cough Test in the Wendy Allen – Nurse Continence Advisor Tension-Free Vaginal Tape Procedure effect upon Voiding Katrina Parkin – Nurse Continence Advisor Dysfunction and 12 month Efficacy. Int Urogyn J, 2012; Wendy Hayes – Physiotherapist 23:435-441.

Research Grants Karantanis E, Painter V, Moore KH. Does patient activity level affect 24-hour pad test results in stress-incontinent NHMRC – 2009-2012 women? Neurol & Urodyn 2012; 31: 143-147 . Principal investigators – R. Chess-Williams, E. Burcher, KH. Moore, Non-neuronal ATP: Regulation of release and Ho M, Kuteesa W, Short A, Eastwood A, Moore KH. Action in the bladder Incontinence after childbirth: Long-term analysis of direct Total awarded; years funded - $ 420,000; 2009-2012. costs of conservative and surgical therapy. Aust NZ Cont J 2012; 18: 10-19 UNSW Faculty of Medicine 2012 – “Silver Star” Grant in recognition of high score non-funded NHMRC Grant Hannan TJ, Totsiks M, Mansfield KJ, Moore KH, Schembri application. MA, Hultgren SJ. Host-Pathogen Checkpoints and Principal investigators – Professor Kate Moore Population Bottlenecks in Persistent and Intracellular Total awarded $20,000. Uropathogenic E Coli Urinary Tract Infection. FEMS Microbiol Rev. 2012 36:616-48. Thera Vida Randomised Control Trial 2011-2012. Principal investigators – Professor Kate Moore 2013 Total awarded $30,000. Walsh CA, Cheng Y, Mansfield KJ, Parkin K, Mukerjee C, Research Projects in Progress Moore KH. Decreased intravesical ATP in patients with refractory detrusor overactivity and bacteriuria. J Urol Prospective Multicentre observational trial of vaginal 2013; 189: 1383-7. oestriol cream for women with stress incontinence, KH Moore Sydney, JP Roovers Amsterdam, S Jeffries, Cheng Y, Mansfield KJ, Allen W, Millard RJ, Burcher E, Capetown Moore KH. Correlation between Cystometric volumes, ATP release, and pH in women with overactive bladder versus Prospective observational study of Patient Motivation controls. Neurourol Urodyn. 2013;32:969-73 Questionnaire in relation to pelvic floor physiotherapy compliance, KH Moore, E Karantanis W Hayes, K Parkin, W Mansfield KJ, Cowan T, Cheng Y, Allen W, Moore KH. Allen. Predicting refractory Detrusor overactivity: Are there any clues at Diagnosis? EMJ Urology 2013; 1: 87-91. Randomised placebo controlled trial of antibiotics for patients with refractory detrusor overactivity, KH Moore, K

116 Moore KH, Allen W, Woodman J, Bushati A, Burcher E. Coli reduces stretch induced ATP release. Journal E. Response to resiniferatoxin in women with refractory of Urology 2012; 187: e368-369, American Urological detrusor overactivity: Role of bacterial cystitis. Aust NZ Assosciation, Chicago. Cont J 2013; 19: 66-73. Cheng Y, Mansfield KJ, Burcher E,Moore KH. ATP Wong V, Kim S, Moore KH. Why are some women with release during bladder filling in women with bladder pelvic floor dysfunction unable to contract their pelvic floor oversensitivity. American Urological Assosciation, Chicago muscles? ANZJOG 2013; Oct 1. doi: 10.1111/ajo.12133. Journal of Urology 2012; 187: e934-e935.

Hagen S, Stark D, Glazener C, Dickson S, Barry S, Elders Mansfield KJ,Moore KH, Cheng Y, Schembri M. Effect of A, Frawley H, Galea MP, Logan J, McDonald A, McPherson Escherichia coli lipopolysaccharide on stretch-induced ATP G, Moore KH, Norrie J, Walker A, Wilson D, Individualised release from cultured urothelial cells. Beijing ICS meeting Pelvic Floor muscle training in women with pelvic organ Neurourol & Urodyn 2012; 31: 1024-1025. prolapse: a multicentre randomised controlled trial. doi: Bahadory F, Markus I, Cheng Y, Moore KH, Liu L, Burcher 10.1016/SO140-6736 (13) 61977-7 Epub 27th Nov 2013 E. Gene expression of purinergic, muscarinic and Lancet. tachykinin receptors in porcine bladder: comparison in Davidson JE, Moore KH. Is Pelvic Floor Muscle Training fresh tissue and cultured urothelium, myofibroblast and as Effective for Urinary Incontinence in the Elderly as detrusor muscle cells. 2012 Beijing; Proc. ICS meeting, Compared to the General Population? A&NZ Cont J Poster. 2013: 19:18-25. Cheng Y, Mansfield KJ, Schembri M, Moore KH. Novel Deepak I, Sundac L, Benjamin W, Moore KH, Ulett G. Fluorescent staining methods for detection of adherent Asymptomatic bacteriuria: prevalence rates of casual with Intracellular Bacteria in urothelial cells from patients microbes, etiology of infection in different patient with refractory urgency. International Urogynaecology populations, and recent advances in molecular detection. Association ASM (IUGA) Brisbane – Oral Presentation. Int. FEMS Microbiol Lett. 2013; 346: 1-10. Urogyn J, 23; S117-S118.

Other Published Material Hayes W, O’Toole J, Thakkar A, Karantanis E, Moore KH. Randomized Controlled Trial: Extracorporeal Magnetic Book Chapter Innervation versus Pelvic Floor Muscle Training in Women with Stress Urinary Incontinence. 2012 IUGA Brisbane – Moore KH, Subak L, Wagner TH, De Wachter S, Dudding Oral Presentation. Int. Urogyn, J, 23; S213-S214. T. Economics of Urinary & Faecal Incontinence, and Prolapse. Report of World Health Organisation, Editors: 2012 National Abrahams P, Cardozo L, Koury S, Wein A. 2012; 1829-1861 Health Publications Ltd., Plymouth. Bahadory F, Markus I, Cheng Y, Moore KH, Liu L, Burcher E. Gene expression of neurochemical receptors in porcine Text Book bladder and cultured cells: comparison in urothelium, myofibroblasts and detrusor. St George Medical Research Moore, KH. Urogynecology in Evidence Based Clinical Foundation. Oct 2012, Prize for Best Poster. Practice. Second Edition. Textbook. Editor Moore, KH. 2012. ISBN: 9781447142904. Invited to write the second 2013 International edition of this monograph by Springer-Verlag, London. Cheng Y, Mansfield KJ, Mukerjee C, Allen W, Schembri Presentations at Scientific Meetings and MA, Moore KH. Development of Novel Techniques Conferences for Investigation of Intracellular Bacteria in Urothelial Cells from Patients with Incontinence. International 2012 International Urogynaecological Association Meeting Dublin. Int. Urogyn J, 2013; 24: 123 – 124. Mansfield KJ, Cheng Y,Moore KH. Treatment of urothelial cells with lipopolysacchardie from enteropathogenic 117 Chen Z, Wong V, Moore KH. Nine year subjective and International Continence Society August, Barcelona, Objective follow up of the Ultra-lateral Anterior Vaginal poster. Repair for Cystocoele. International Urogynaecological Cheng Y, Mansfield KJ, Allen W, Millard R, Burcher E, Association Meeting, Dublin. Int. Urogyn J, 2013; 24: . Correlation Between Cystometic Volumes, 59– 61. Moore K ATP Release and pH in Women with Overactive Bladder Wong V, Guzman RA, Rojas K, Shek K, Chou D, Versus Controls Neurourol & Urodyn 2013; 32: 969-973 Moore KH, Dietz P. Predictors of prolapse recurrence International Continence Society Barcelona. following laparoscopic sacrocolpopexy. International 2013 National Urogynaecological Association Meeting Dublin. Int. Urogyn J, 2013; 24: 64 – 65. Chen Z, Wong V, Wang A, Moore KH. Nine year subjective and objective follow up of the Ultra-Lateral Cheng Y, Moore KH. Comparison of Nitric Oxide release Anterior Vaginal Repair for Cystocoele. UGSA meeting during urodynamic test between detrusor overactive Garvan Institute of Medical Research, March. women and controls. Neurourol & Urodyn 2013; 32: 746- 48 International Continence Society Barcelona. Leek H, Reus A, Stephenson Z, Karantanis E, Moore KH. Clean Intermittent Self-Catheterisation: An RCT of single- Bahadory F, Burcher E, Moore KH, Liu L. The gene use versus multiple re-use of Catheters – UTI Risk and Cost expression of target proteins and receptors for Botox Implications. UGSA meeting Garvan Institute of Medical in porcine bladder, and down regulation of SNAP-25 in Research, March. cultured cells, International Continence Society. August, Barcelona, poster. Community Engagement Wong V, Rodirgo Guznian R, Sheu KL, Chow D, Moore Professor Kate Moore KH, Dietz P. Cystocele recurrence following laparoscopic sacrocolpopexy: How low does the mesh go? Neurourol Professor Kate Moore is the inaugural Chairman of the & Urodyn 2013; 32: 705-707 International Continence Urogynaecological Society of Australasia, a society of Society Barcelona. continence clinicians, which aims to promote research, training and education about pelvic floor dysfunction Wong V, Kim S, . How common is levator Moore KH across Australia and New Zealand. The Society holds an muscle defect in women with acontractile pelvic floor. Annual Scientific meeting, attended by approximately 200 International Continence Society, August, Barcelona. gynaecologists, physio therapists and nurse continence Parkin K, Walsh D, Hayes W, Wong V Karantanis E, advisors, as well as a workshop attached to the RANZCOG Moore KH. Does the Incontinence treatment motivation annual meeting and also holds regional meeting (e.g. questionnaire (ITMQ) predict response to pelvic Mackay, Cairns). The society administers the Australian floor physiotherapy for Stress Urinary Incontinence? Pelvic Floor Surgery Database, which enables monitoring International Continence Society August, Barcelona, of surgical outcomes, including the use of polypropylene poster. mesh for prolapse surgery.

Leek H, Reus A, Stephenson Z, Karantanis E, Moore K. Clean Intermittent Self-Catheterisation: A randomised Control Crossover Trial of single-use versus multiple re-use of non-coated catheters; is cystitis rate altered? Neurourol & Urodyn 2013; 32: 759-760 International Continence Society Barcelona.

Cowan T, Mansfield KJ, Cheng Y, Allen W,Moore K. Does Intravesical ATP or Recurrent Bacterial Cystitis predict response to antimuscarinics in Detrusor Overactivity.

118 > Department of Women’s Health

Head of Department Dr Trent Miller – Staff Specialist Obstetrician & Gynaecologist, Training Supervisor St George Hospital, Professor Michael Chapman – MBBS, MD, FRCOG, Conjoint Lecturer UNSW. MBBS(Hons), FRANZCOG FRANZCOG, CREI Professor of Obstetrics & Gynaecology Co-Director of Dr Michael O’Connor AM – VMO Obstetrics & Women’s & Children’s Health St George Hospital, Head of Gynaecology, Conjoint Senior Lecturer UNSW. MD. BS School - Women’s & Children’s Health UNSW (Hons), MHL (Syd), DCH.DDU.MRCOG (Gold Medal). FRCOG. FRANZCOG.FACLM. Senior Medical Dr James Opperman – VMO Obstetrics & Gynaecology. Professor Kate Moore – Professor of Obstetrics & MBBS (Syd. Hons.), FRANZCOG Gynaecology UNSW, Urogynaecologist. MB BS Syd, MD Liv, FRCOG, FRANZCOG, CU Dr David Rosen – VMO Gynaecology, Laparoscopic Surgeon. MBBS FRANZCOG A/Prof Greg Davis - Senior Staff Specialist Obstetrician & Gynaecologist, Conjoint A/Prof UNSW/Adj Prof UTS. Dr Steven Thou – Staff Specialist Obstetrician & MBChB, MD, FRCOG, FRANZCOG Gynaecologist, Conjoint Lecturer UNSW.BSc (Med) (Hons), MBBS (Hons), FRANZCOG A/Prof Gavin Sacks – Staff Specialist Obstetrician, Fertility Specialist, Conjoint A/Prof UNSW. MA (Cantab) BM BCh Dr Queeny Wong – VMO Obstetrics. MBBS, FRANZCOG (Ox) PhD (Ox) MRCOG FRANZCOG CCSST (UK) Dr Andrew Zuschmann - Staff Specialist Obstetrician Dr John Breen – Staff Specialist Obstetrician & & Gynaecologist, Fertility Specialist, Conjoint Lecturer Gynaecologist, Conjoint Lecturer UNSW. BSc Hons, UNSW. BSc(Med) MBBS MReprodMed (UNSW) MBChB, MRCOG, FRANZCOG FRANZCOG

Dr Greg Cario – VMO Obstetrics & Gynaecology, Junior Medical Laparoscopic Surgeon, Conjoint Senior Lecturer UNSW. Dr Trupti Kanade – Fellow in Laparoscopic Surgery MB, BS (Syd) Hons, FRANZCOG, FRCOG Dr Shadi Khashaba – Fellow in Reproductive Dr Danny Chou – VMO Gynaecology, Laparoscopic Endocrinology & Infertility Surgeon, Conjoint Lecturer UNSW. MBBS MRCOG Dr Joanne McKenna –Fellow in Laparoscopic Surgery FRANZCOG Dr Brian Tsai – Fellow in Laparoscopic Surgery Dr Christos Venetis – Fellow in Reproductive Dr Ludmilla Collins – VMO Obstetrics & Gynaecology. Endocrinology & Infertility MBBS, FRANZCOG Senior Midwifery Research Fellow Dr Amanda Henry – Consultant Obstetrician, Lecturer UNSW. MA Public Health, FRANZCOG, B.Med. (Hons) Professor Caroline Homer PhD, RN, RM (Professor of ,B.Med.Sci (Hons), DDU(O&G) Midwifery, UTS)

Dr Emmanuel Karantanis - Staff Specialist Obstetrician & Research Midwife Gynaecologist, Conjoint Senior Lecturer UNSW. BSc(Med), Mrs Lynne Roberts MMid MHSc MBBS(Hons), FRANZCOG, PhD, CU

Dr Gavin Kemball – VMO Obstetrics & Gynaecology, Research Grants Fertility Specialist, Conjoint Lecturer UNSW. MBBS, NHMRC Project Grant: De Lacey S; Chapman MG; Ratcliffe MRCOG, FRANZCOG, BSc, MSc J. Acupuncture to improve live birth rates for women Dr Chandra Krishnan – Staff Specialist Obstetrician, undergoing IVF: a randomised controlled trial. Total Grant: Fertility Specialist, Conjoint Lecturer UNSW. MB BS (Syd) $634,969 (2011-15). FRANZCOG ARC Discovery Grant: Foureur M, Homer CSE, Fenwick J, 119 Davis D, Sorensen R, Forbes I. Theorising the relationship Department of Women’s Health is a Collaborating Centre between birth unit design and the communication patterns for the following multicentre randomised controlled trials: of labouring women and their maternity care providers. Australasian antenatal Study To Evaluate the Role Of 2012: $91,340; 2013: $86,140. Intramuscular Dexamethasone versus betamethasone NHMRC Project Grant: Homer CSE, Ellwood D, Oats J, (ASTEROID) Study. Principal Investigator: Prof Caroline Foureur MJ, Sibbritt D, McLachlan H, Forster D, Dahlen Crowther. University of Adelaide and Women’s and H. Birthplace in Australia: A prospective cohort study. Children’s Hospital, Adelaide. Site Investigator SGH A/Prof $790,175 (2012-2015). Greg Davis.

NHMRC Project Grant: Homer CSE, Foureur MJ, Davis Candida in Pregnancy study (CiPS). Principal Investigator: D, Adams J, Porteous A. Does Continuity Of Midwifery Prof Jonathon Morris. University of Sydney at Royal North Care Increase Vaginal Birth After Caesarean (VBAC): A Shore Hospital. Site Investigator SGH: A/Prof Greg Davis. Randomised Controlled Trial. $257,550 (2012-2015). MAgnesium sulphate at 30 to 34 weeks’ GEstational NHMRC Project Grant:– Kildea S, Martensson L, Webster age: Neuroprotection TriAl (MAGENTA). Principal J, Homer CSE, Stapleton H, Beckmann M, Gao Y, Gibbons Investigator: Prof Caroline Crowther. University of Adelaide K. Impact on Caesarean Rates following Injections of and Women’s and Children’s Hospital, Adelaide. Site Sterile Water (ICARIS) – A randomised controlled trial. Investigator SGH: A/Prof Greg Davis. $456,760 (2012-2014). Preterm Prelabour Rupture Of Membranes close to Term St George and Sutherland Medical Research Foundation. (PPROMT) Trial. Principal Investigator: Prof Jonathan Clinical Researcher Award for 2013. Henry A, $20,000, Morris. Royal North Shore Hospital, Sydney. Site (2013). Investigator SGH: A/Prof Greg Davis.

Australasian Society of Ultrasound in Medicine Research PROGesterone after previous preterm birth for the Grant Fetal cardiovascular evaluation after maternal prevention of neonatal RESpiratory distress Syndrome betamethasone Vs dexamethasone administration. Welsh (PROGRESS) Trial. Principal Investigator: Prof Caroline A, Henry A, Shand A. $15,000 (2012). Crowther. University of Adelaide and Women’s and Children’s Hospital, Adelaide. Site Investigator SGH: A/ UNSW Medicine Major Research Equipment and Prof Greg Davis. Infrastructure Initiative. Henry A, Welsh A, Abbott J, Nesbitt-Hawes E, Schindler, T. $100,000, (2013). Triggers for pre eclampsia. Principal Investigator: Dr Jane Ford. University of Sydney at Royal North Shore Hospital. Research Projects in Progress Site Investigator SGH: A/Prof Greg Davis.

Fetal cardiovascular response to maternal corticosteroid Original Peer-Reviewed Publications administration: a comparison of dexamethasone versus betamethasone” (Short title: SUPER-A*STEROID). Henry A, 2012 Welsh AW, Shand A, Crowther C, Davis G, Palmer A. Amari E, Fowler C, Homer CSE. Bed sharing with infants Fetal Doppler and the Tei index for evaluation of normal in a time of SIDS awareness. Neonatal Paed Child Health and pathological pregnancy. Henry A, Welsh AW. Nurs 2012;15(2): 3-7.

Third trimester ultrasound: an audit of current practices at Brown MA, Roberts LM, Mackenzie C, Mangos GJ, Davis St George Hospital. Henry A, King K, Foo J. GK. A Prospective Randomised study of Automated versus Mercury blood pressure recordings in hypertensive Midwifery-led intervention group for pregnant women of pregnancy (PRAM study). Hypertens Preg. 2012; 31:107- high body mass index: engagement with and outcomes of 119. SSWInG. Henry A, Chwah S, Reilly A, Hall B, O’Sullivan A. Budden A, Henry A, Heatley E. Oxytocin infusion Triggers for delivery in pre-eclampsia: a retrospective regimens for induction of labour (protocol). Cochrane cohort study. Henry A, Varnier N, Brown M, Pettit F, Library, Issue 3, 2012. Mangos G, Davis G. Catling-Paull C, Foureur MJ, Homer CSE on behalf of the Trajectory of platelets in pregnancy. Henry A, Duong C, members of the Publicly-funded Homebirth Consortium. Kidson-Gerber G. Publicly-funded homebirth models in Australia. Women Postpartum Physiology, Psychology and Paediatric (P4) Birth 2012; 25: 152-158. follow up study. Principal Investigator Davis G.

120 Dahlen HG, Homer CSE. Web-based News Reports on Painter V, Karantanis E, Moore KH. Does patient activity Midwives Compared with Obstetricians: A Prospective level affect 24-hr pad test results in stress-incontinent Analysis. Birth. Article first published online: 9 Jan 2012. women? Neurourol Urodyn. 2012;31(1):143-7 DOI: 10.1111/j.1523-536X.2011.00512.x Smith RM, Brodie PM, Homer CSE. (2012) Reviewing Dahlen, H.G., Homer, CSE. Motherbirth or childbirth? A and reflecting on practice: the midwives experiences of prospective analysis of vaginal birth after caesarean blogs. credentialing. Women Birth 2012; 25: 159-165. Midwifery 2012;29: 167-173. Roth H, Homer CSE, Fenwick J.) “Bouncing back”: Henry A, Clements S, Kingston A, Abbott J. In search How Australia’s leading women’s magazines portray the of work/life balance: trainee perspectives on part-time postpartum ‘body’. Women Birth 2012; 25:128-128. obstetrics and gynaecology specialist training. BMC Res Sacks G; Fay L; Chapman M; Smith S; Yang Y; Gowen E. Notes 2012; 5:19 doi:10.1186/1756-0500-5-19 Detailed Analysis of Peripheral Blood Natural Killer Cells in Hawkins T, Roberts J, Mangos G, Davis G, Roberts L, Women with Repeated IVF Failure. Am J Reprod Immunol. Brown M. Plasma uric acid remains a marker of poor 2012; 67: 434 – 442. outcome in hypertensive pregnancy: A retrospective Shahheidari M, Homer CSE. Impact of the design of cohort study. BJOG.2012; 119:484-492. Neonatal Intensive Care Units on neonates, staff, and Hawkins TL, Brown MA, Mangos GJ, Davis GK. Transient families: A systematic literature review. J Perinat Neonat gestational hypertension: Not always a benign event. Preg Nurs 2012; 26(3):260-6. Hypertens: Int J Women’s Cardiovasc Health 2012; 2(1): Smith CA; de Lacey S; Chapman M; Ratcliffe J; Norman 22-27. RJ; Johnson N; Sacks G; Lyttleton J; Boothroyd C. Homer CSE, Catling-Paull C. Safe timing for an urgent Acupuncture to improve live birth rates for women caesarean section: What is the evidence to guide policy? undergoing in vitro fertilization: A protocol for a Aust Health Rev 2012; 36 (3): 277-281. randomized controlled trial. Trials 2012, 13:60

Homer CSE, Allende T, Pekin F, Caplice S, Catling-Paull C, Smith, R, Gray, J, Raymond, J, Catling-Paull, C, Homer, Foureur MJ. It’s more than just having a baby. Women’s CSE. Integrating simulation into a theoretical subject experiences of a maternity service for Aboriginal and for midwifery students. Clin Simul Nurs. 2012; 8(9): Torres Strait Islander families. Midwifery 2012;28(4): e451-e457. E449-E455. Vaughan G, Pollock W, Peek M, Knight M, Ellwood Homer CSE, Griffith M, Brodie PM, Kildea S, Curtin A, D, Homer CSE, Jackson-Pulver L, McLintock C, Ho T, Ellwood D. Developing a core competency model and Sullivan EA. Ethical issues: the multi-centre low-risk ethics/ educational framework for primary maternity services: a governance review process and AMOSS. Aust N Z J national consensus approach. Women Birth 2012; 25(3): Obstet Gynaecol 2012; 52:195–203. 122-127. Wheeler J, Davis D, Brodie PM, Fry M, Homer CSE. Is Homer CSE, Lees T, Stowers P, Aiavao F, Sheehy A, Barclay Asian ethnicity an independent risk factor for severe LM. Traditional birth attendants in Samoa: Integration with perineal trauma in childbirth? A systematic review of the the formal health system. Int J Childbirth. 2012; 2(1): 5-11. literature. Women Birth 2012; 25(3):107-13.

Ith P, Dawson A, Homer CSE. (2012) Quality of Maternity 2013 Care Practices of Skilled Birth Attendants in Cambodia. Int Catling-Paull C, Coddington R, Foureur M, Homer CSE. J Evid Based Healthc 10: 60–67. Publicly-funded homebirth in Australia: A review of Koch J; Rowan K; Rombauts L; Yazdani A; Chapman M; maternal and neonatal outcomes for the last 6 years. Med Johnson N. Endometriosis and Infertility - A consensus J Aust 2013;198(11): 616-620. statement from ACCEPT (Australasian CREI Consensus Chambers GM; Wang YA; Hoang VP; Sullivan EA; Expert Panel on Trial evidence) Aust N Z J Obstet Chapman MG; Ledger W; Abdalla HI. What can we Gynaecol 2012; 52: 513 – 522. learn from a decade of promoting safe embryo transfer Moore KH, Shahab RB, Walsh CA, Kuteesa WM, Sarma S, practices? A comparative analysis of policies and Cebola M, Allen W, Wang YA, Karantanis E. Randomized outcomes in the UK and Australia, 2001-2010. Hum controlled trial of cough test versus no cough test in the Reprod 2013; 28: 1679 - 1686 tension-free vaginal tape procedure: effect upon voiding Chapman MG; Sacks G. Recurrent miscarriage: dysfunction and 12-month efficacy. Int Urogynecol J. Investigating the potential causes. Med Today. 2013. 13: 2012; 23(4):435-41. 61 - 65 121 Dawson A, Brodie PM, Copeland F, Rumsey M, Homer Homer CSE, Catling CJ, Scarf VL, Sibbritt D. The profile of CSE. Collaborative approaches towards building women who consult midwives in Australia. Women Birth midwifery capacity in low income countries: A review of 2013;26: 240-245. experiences. Midwifery; Epub 2013 Jul 1, doi: 10.1016/j. Ith P, Dawson A, Homer CSE. Women’s perspective of midw.2013.05.009. maternity care in Cambodia. Women Birth 2013;26: 71–75. Dawson, AJ, Buchan J, Duffield, C, Homer CSE, Ith P, Dawson A, Whelan A, Homer CSE. Practices of Wijewardena, K. Task shifting and sharing in maternal and skilled birth attendants during labour, birth and the reproductive health in low-income countries: A narrative immediate postpartum period in Cambodia. Midwifery synthesis of current evidence. Health Policy Plan 2013; doi: 2013;29(4): 300-7. 10.1093/heapol/czt026. Lee N, Mårtensson LB, Homer C, Webster J, Gibbons K, Dawson A; Homer C. Managing the International Stapleton H, Dos Santos N, Beckmann M, Gao Y, Kildea S. Humanitarian and Development Health Workforce: A Impact on Caesarean section rates following injections of review of experiences and needs. Asia Pac J Health sterile water (ICARIS): a multicentre randomised controlled Manage. 2013. 8(1): 14-23. trial. BMC Preg Childbirth 2013, 13:105. Dawson A, Homer CSE. How does the mining industry Listijono DR; Chapman MG; Boylan T; Cooke S; Kilani S. contribute to sexual and reproductive health in developing An analysis of the impact of embryo transfer difficulty on countries. J Clin Nurs 2013; 22 (23-24): 3597–3609. live birth rates, using a standardised grading system. Hum Farrokh-Eslamlou H, Eslamli M, Aghlmand S, Homer CSE. Fertil (Camb). 2013; 16(3): 211-4. The impact of World Health Organization’s Decision- McLindon LA; Beckmann M; Flenady V; McIntyre HD; Making Tool for Family Planning Clients and Providers on Chapman M. Women’s views of a fertility awareness and the Quality of Family Planning Services in Iran. J Fam Plan hormonal support approach to subfertility. Hum Fertil Reprod Health Care 2013;0:1–7. (Camb). 2013;16:252-7. Gray JE, Leap N, Sheehy A. Students’ perceptions of Raymond J, Smith RM, Gray JE, Homer CSE. Learning the follow-through experience in three year Bachelor through authentic assessment: an evaluation of a new of Midwifery Programs in Australia. Midwifery 2013;29, development in the undergraduate midwifery curriculum. 400–406. Nurse Educ Pract 2013;13(5): 471–476. Halliday L, Sullivan E, Peek M, Ellwood D, Homer CSE, Richter J, Henry A, Ryan G, DeKonninck P, Lewi L, Deprest Knight M, McLintock C, Jackson-Pulver L. The Australasian J. Amniopatch procedure after previable iatrogenic Maternity Outcomes Surveillance System (AMOSS): rupture of membranes: a two centre review. Prenat Diagn An evaluation of stakeholder engagement, usefulness, 2013; 33(4): 391-6. simplicity, acceptability, data quality and stability. Aust N Z J Obstet Gynaecol 2013;53(2):152-7. Russell P, Sacks G, Tremellen K, Gee A The distribution of immune cells and macrophages in the endometrium Hammond A, Foureur M, Homer CSE, Davis D. Space, of women with recurrent reproductive failure: Further place and the midwife: Exploring the relationship between observations and reference ranges. Pathology. 2013; the birth environment, neurobiology and midwifery 45:393-401 practice. Women Birth 2013; 26(4): 277-281. Sanderson J, Wu L, Mahajan A, Meriki N, Henry A, Welsh Henry A, Madan A, Reid R, Tracy SK, Austin K, Welsh AW, A. Selection of the Sub-Noise Gain level for acquisition of Challis D. Outpatient Foley catheter versus inpatient VOCAL datasets: a reliability study. Ultrasound Med Biol prostaglandin E2 gel for induction of labour: a randomised 2013; DOI: 10.1016/j.ultrasmedbio.2013.09.004. trial. BMC Preg Childbirth 2013, 13:25. Shaban I, Hatamleh, R, Homer CSE. Evaluating the Henry A, Shand A, Welsh AW. The short term fetal Experience of Jordanian Women with Maternity Care cardiovascular effects of corticosteroids used in obstetrics. Services. Health Care Women Int 2013;34(6):499-512. Austral J Ultrasound Med 2013; 16: 128-134. Sheehy A, Davis D, Homer CSE. Assisting women to Homer CSE, Besley K, Bell J, Davis D, Adams J, Porteous make informed choices about screening for Group B A, Foureur M. Does continuity of care impact decision Streptococcus in pregnancy: A critical review of the making in the next birth after a caesarean section (VBAC)? evidence Women Birth 2013;26: 152–157. A randomised controlled trial [Trial Protocol]. BMC Preg

Childbirth 2013,13:140.

122 Teate A, Leap N, Homer CSE. Midwives’ experiences of Davis GK, Roberts LM, Mangos G, Brown MA. The UM- becoming CenteringPregnancy facilitators: A pilot study in 101 mercury-free sphygmomanometer: a replacement for Sydney, Australia. Women Birth 2013; 26(1): e31–e36. mercury sphygmomanometry at last? Biennial Scientific Meeting ISSHP 2012, Geneva (Poster) Tracy SK, Hartz DL, Tracy MB, Kildea S, Allen Y, Forti A, Hall B, Lainchbury A, Stapleton H, Beckmann M, Bisits 2012 - National A; Homer CSE, Foureur M, White J, Welsh A. Caseload Chen L, Gardiner A, Austin K, Kidson-Gerber G, Henry midwifery care for women of all risk compared to standard A. Iron sucrose infusion in pregnancy. RANZCOG Annual hospital care: a randomized controlled trial. (Midwives Scientific Meeting, Canberra, 2012. @ New Group practice Options: M@NGO trial.) Lancet 2013;382 (9906): 1723 – 1732 Davis GK, Roberts LM, Mangos G, Brown MA. The UM- 101 mercury-free sphygmomanometer: a replacement for Vallely, LM Homiehombo P, Kelly AM, Vallely A, Homer mercury sphygmomanometry at last? Society of Obstetric CSE, Whittaker, A. Exploring women’s perspectives Medicine of Australia and New Zealand. Annual Scientific of access to care during pregnancy and childbirth: A Meeting. Sydney 2012. qualitative study from rural Papua New Guinea. Midwifery 2013;29(10):1222-9. Dilgir S, Parkin K, Patton V, Lubowski D, Karantanis E. Other Published Material Predictive factors for Obstetric Anal Sphincter Injury. IUGA ASM Brisbane 2012. Atchan M, Homer CSE. (2013) Routine care of postpartum Everitt L, Homer C, Fenwick J. Midwives Experience of women. In J. Abbott, L Bowyer, M Finn [Eds]. Obstetrics Working with Community Services during Assumption and Gynaecology: An Evidence-Based Guide. Elsevier of Care of Newborns. Breathing New Life into Maternity Australia [219-230]. Care: Working together: balancing risk in maternity care. Henry A. Chapter 13. Infections in pregnancy. In: Abbott Melbourne 2012. J, Bowyer L, Finn M (eds). Ot. Elsevier Australia 2013. Everitt L, Lock K, Fenwick J, Homer C. Breastfeeding and Presentations at Scientific Meetings and assumption of care of newborns. The Inaugural Lactation Conferences Consultants of Australia and New Zealand (LCANZ) Conference. Sydney 2012. 2012 - International Everitt, L. Learning to play the hard course: Midwives role Chapman MG. Corifollitropin Alfa – IVF Australia’s First 100 in assumption of care of newborns. Australian College Cases FSA Meeting, Auckland, New Zealand, 2012 Midwives – NSW Branch Inc. Annual State Conference, Playing the Course: A Round in Midwifery. Wyong 2012. Chapman MG. Invited Speaker: Selection of the best oocyte. Midwestern Reproductive Symposium, Chicago, Hayes W, O’Toole J,Thakkar A, Moore K, Karantanis E. IL, USA, 2012 Randomised Control Trial of Electromagnetic Chair versus PElvic Floor Physiotherapy for women with stress urinary Homer CSE. (2012). Unravelling evidence based practice in incontinence. IUGA ASM 2012 Brisbane. policy and reality – local, national, and international stories from the field. Invited keynote speaker at Celebrating Homer CSE, Foureur M. The Potential Epigenetic Impact Success: Turning best practice into common practice in of Peripartum Events and Long-term Cardiovascular maternal and infant health and care, University of York, UK. Health. Invited speaker at the Royal Hospital for Women Annual Symposium: Celebrating 100 years of Antenatal Homer CSE, Lees T, Stowers P, Aiavao F, Sheehy A, Care, Sydney 2012. Barclay LM. (2012) Traditional birth attendants in Samoa: Integration with the formal health system. ICM Asia Pacific Homer CSE, Sandall J, Nicholl M, Redshaw M. Designing Conference, Vietnam. a woman centered maternity service – balancing safety, cost, geography and reality. Invited full day workshop Meriki N, Henry A, Welsh AW. Development of normal at Breathing New Life into Maternity Care, 4th Biennial gestational ranges for the right myocardial performance Conference. Melbourne 2012. index in the Australian population with 3 alternative caliper placements. Ultrasound in Obstetrics and Gynaecology Homer CSE. The Homebirth consortium study. Place 2012; 40 (Suppl 1): 137. of Birth and Models of Care Conference. University of Western Sydney, 2012. Welsh AW, Meriki N, Henry A. The ‘Delta-MPI’: a new measure for unilateral fetal myocardial strain and its Roberts LM. What’s new in recording blood pressure normal gestational range. Ultrasound in Obstetrics and in pregnancy? St George Hospital Midwifery Seminar: Gynaecology 2012; 40 (Suppl 1): 138 Working Together. Sydney 2012. 123 Chapman MG. Polarised light microscopy in oocyte and Gynaecology RANZCOG Annual Scientific Meeting, selection RANZCOG CREI Annual Meeting, Sydney, 2012 Sydney, 2013 (e-poster).

Chapman MG. Current Concepts on assisted reproduction Chapman MG. Invited Speaker: Preparing for retirement. and fertility preservation ESA-SRB Meeting, Gold Coast, RANZCOG ASM, Sydney, 2013. 2012 Chapman MG. Guideline preparation. RANZCOG CREI 2013 - International Annual Meeting, Sydney, 2013.

Henry A, Welsh AW. Monitoring cholestasis of pregnancy Chwah S, Reilly A, Hall B, Henry A. Midwifery-led using the fetal modified myocardial performance index intervention group for pregnant women of high body (mod-MPI). 23rd World Congress on Ultrasound in mass index: engagement with and outcomes of SSWInG. Obstetrics and Gynecology, Sydney, 2013. RANZCOG Annual Scientific Meeting, Sydney, S2013 (e-poster). Henry A, Meriki N, Mahajan A, Sanderson J, Wu L, Welsh AW. Delta-MPI in pathological versus uncomplicated Everitt L, Homer C, Fenwick J. Assumption of care of a pregnancies: a value-add to right and left mod-MPI? newborn: How can you be prepared? Australian College 23rd World Congress on Ultrasound in Obstetrics and of Midwives 18th Biennial Conference, October, Hobart, Gynaecology, Sydney 2013. Australia. Abstract published in Women Birth 2013;26: S1: S6. Henry A, Shand A, Crowther C, Palmer A, Wang YA, Welsh AW. Comprehensive ultrasound evaluation of short-term Hammond A, Foureur M, Homer C, Davis D. The hospital fetal effects of dexamethasone and betamethasone. birth environment: Impacts on midwifery practice during 23rd World Congress on Ultrasound in Obstetrics and labour and birth. Australian College of Midwives 18th Gynaecology, Sydney, 2013. Biennial Conference, October, Hobart, Australia. Abstract published in Women Birth 2013;26:S1: S8. Homer C, Brodie P, Copeland F, Rumsey M, Dawson A. We kam longwe so far: Building midwifery capacity in Papua Henry A, Lees N, Bein K, Hall B, Lim V, Chen K, Welsh A, New Guinea. Pacific Society for Reproductive Health Hui L, Shand AW. Pregnancy outcomes before and after Conference, July Apia, Samoa 2013. institution of specialised Twins Clinic Care. RANZCOG 2013 Annual Scientific Meeting, Sydney, 2013. Kanade T, Kulkarni S A, Sheregar N. Laparoscopic management of grade IV endometriosis – TRICKS OF Homer C, Rumsey M, Brodie P, Dawson A, Copeland F, TRADE. 41st Annual Conference of Mumbai Obstetrics Daly J. (2013). Helping build foundations to improved and Gynaecologic Society (MOGS). Juhu, Mumbai 2013. maternal health in PNG. International Council of Nurses 25th Quadrennial Congress, Melbourne 2013. Meriki N, Henry A, Sanderson J, Mahajan A, Wu L, Welsh AW. Normal ranges for the right modified myocardial Homer C. Connections, Continuity and Community: performance index (RMPI) in the Australian population Models of care for Aboriginal and Torres Strait Islander using three alternative caliper placements. 23rd World women. Perinatal Society of Australia and NZ 17th Annual Congress on Ultrasound in Obstetrics and Gynaecology, Congress. April, Adelaide, Australia. Abstract published in Sydney, 2013. J Paed Child Health 2013;49:S2: 7.

O’Connor M. Sexual Violence as a Weapon in Armed King K, Foo J, Henry A. Third trimester ultrasound: Conflict. 40th World Congress of Military Medicine. an audit of current practices at St George Hospital. Jeddah. Kingdom of Saudi Arabia, 2013. RANZCOG Annual Scientific Meeting, Sydney, 2013.

Chapman MG. Invited Speaker: Other Than Kangaroos, Kruske S, Schmied V, Homer C. Midwives confidence Does Australia Have Anything to Offer In Reproduction? in the skills required for postnatal care: Results of a Midwestern Reproductive Symposium, Chicago, IL, USA, national survey. Australian College of Midwives 18th 2013. Biennial Conference, October, Hobart, Australia. Abstract published in Women Birth 2013;26:S1: S11. 2013 - National Moody T, Fenwick J, Foureur M, Homer C, Davis D Austin K, Chambers G, Susic D, Madan A, De Abreu Exploring ‘domesticity’ in the birthspace. Australian Lourenco R, Henry A. Cost Effectiveness of induction of College of Midwives 18th Biennial Conference, October, Labour at term with inpatient vaginal prostaglandin E2 Hobart, Australia. Abstract published in Women Birth gel compared to an outpatient Foley Catheter (FOG Trial). 2013;26:S1: S14. Royal Australian and New Zealand College of Obstetrics

124 O’Connor M. Legal Protection for ADF Medical Officers in a Quasi Authoritarian Organisation. NSW Military Health Lecture, Randwick Barracks 2013

Raymond J, Homer C, Davis D. The Who, What and Why: Weight management support for obese women during pregnancy. Australian College of Midwives 18th Biennial Conference, October, Hobart, Australia. Abstract published in Women Birth 2013;26:S1: S15.

Pettit F, Davis G, Henry A, Mangos G, Brown MA. Is early onset pre-eclampsia worse for mother or baby? Perinatal Society of Australia and New Zealand Annual Scientific Meeting, Perth, 2013.

Psaila K, Schmied V, Kruske S, Homer C. Transition of care: how well is it done? Findings from the CHoRUS study. Australian College of Midwives 18th Biennial Conference, October, Hobart, Australia. Abstract published in Women Birth 2013;26:S1: S18.

Whitton K, Shand A, Pasfield A, Nassar N, McShane M, Han X, Henry A. Anti-Mullerian hormone: a predictor of adverse pregnancy events? PSANZ Annual Scientific Meeting, Adelaide, 2013.

125

Nursing and Midwifery

Centre for Research in > Nursing and Health 128 > Centre for Research in Nursing and Health

Director of Nursing and Midwifery South Eastern Sydney Local Health District (SESLHD): University of Wollongong $20,000 Vicki Manning RN, BAdmin (Nursing), MPH Fernandez R, Arthur B (2013) Dementia education for Centre for Research in Nursing and Health acute care nurses: NSW Ministry of Health, Dementia Professor Ritin Fernandez RN, PhD School of Nursing and Training Study Centres $50,000 Midwifery - University of Wollongong St George Hospital Fernandez R, Higgs M (2013) Perception of cardiovascular Daniela Levido (Stomal Therapy Clinical Nurse Consultant, risk among offsprings of people with acute coronary Graduate Certificate in Stomal Therapy, BN) syndrome. South Eastern Sydney Local Health District (SESLHD): University of Wollongong $5000 Suzanne Polis (BN, MPH by research, Post grad certificate in Gastroenterology & Hepatology, PhD candidate) George R, Straube B, Cook C, Gallard J, et al. (2013- 2015) Enhancing Intravenous Cannula Care by Patients Megan Higgs (BN, MN, PhD candidate) from Culturally and Linguistically Diverse Backgrounds (ENABLE). SESLHD: Multicultural health service, Cultural Research Grants Diversity Health Enhancement Grants $5,000

Craig D, Fernandez R (2013) Clinical Management of Murray N, Griffith J (2012) Arabic Centering in Pregnancy. Chinese speaking women with Gestational Diabetes South Eastern Sydney Local Health District (SESLHD): Mellitus speaking women with Gestational Diabetes. St Multicultural Health. $8511 George Hospital: Multicultural Health Service Cultural Diversity Health Enhancement Grants Program 2012- Matthews L, Griffith J (2012) Ways of Working (WOW). 2013. $6,800 Maternity Services, St George Hospital: Nurse & Midwifery Office Strategy $16,192 Curtis K, Foster K, Mitchell R (2013) Paediatric Critical Injury Research Program (6 years). South Eastern Sydney Polis S (2013) Adherence to Hepatitis B anti-viral Local Health District (SESLHD): Day of Difference. 574,223 medications. St George Hospital: Gilead Sciences. $13,000

Curtis K, Goldsmith H, Langcake M (2013) Improving Polis S, Pritchard -Jones J (2013) Education needs of outpatient pain management. South Eastern Sydney Local hepatology nursing staff working with patients diagnosed Health District (SESLHD): Motor Accidents Authority of with HCV and HBV related advanced liver disease. St NSW. $13, 676 George Hospital: Pillar Award for Nursing & Allied Health. Roche Pharmaceuticals. $10,000 Curtis K, Murphy M, Hardy J, Lewis M, Strachan L, Buckley DT (2012) Evaluation of an emergency nursing assessment Polis S, Zekry A, Fernandez R (2013) Effect of a nurse framework on patient assessment and documentation: directed model of outpatient care for management A pilot study South Eastern Sydney Local Health District of patients with advanced liver disease: a pilot study (SESLHD): Emergency Care Institute. $99,457.60 St George Hospital: St George & Sutherland Medical Research Foundation. $20,000 Curtis K, Roberts L, Langcake M (2013) Improving the care and outcomes of patients with blunt chest injury. South Ho S, Cook C, Straube B, Fernandez R, et al. (2013-2014) Eastern Sydney Local Health District (SESLHD): Motor The Action Study: Strategies to reduce the VRE infection Accidents Authority of NSW. $14,814 (Transmission and BacteraemIa) rates in high risk patients admitted to 4E/4N wards. SESLHD: SESLHD Infection Falomir C (2013) Cancer Information CALD Wall and Prevention & Control Enhancement Program. $100,000 DVD library. South Eastern Sydney Local Health District (SESLHD): Multicultural Health Service Cultural Diversity Wiseman T, Curtis K, West S (2013) E-learning to improve $1800 trauma care on the wards. South Eastern Sydney Local Health District (SESLHD): Motor Accidents Authority of Fernandez R (2012) Secondary prevention following PCI. NSW. $14, 717.

128 Original Peer Reviewed Publications Curtis K, Caldwell E, Delprado A, Munroe B (2012) Traumatic injury in Australia and New Zealand. Australasian Asha S, Curtis KA, Grant N, Taylor C, Lo S, Smart R, Emergency Nursing Journal 15:45-54. Compagnoni K (2012) Comparison of radiation exposure of trauma patients from diagnostic radiology procedures Curtis K, Chan DL, Lam MK, Mitchell R, King K, Leonard before and after the introduction of a panscan protocol. L, D’Amours S, Black D (2013) The injury profile and Emergency Medicine Australasia 24:43-51. acute treatment costs of major trauma in older people in New South Wales. Australasian Journal on Ageing. DOI: Asha SE, Ajami A (2013) Improvement in emergency 10.1111/ajag.12059 department length of stay using an early senior medical assessment and streaming model of care: A cohort study. Curtis K, Leonard E (2012) The Trauma Nurse Coordinator Emergency Medicine Australasia 25:445-451. in Australia and New Zealand: Demographics, Role, and Professional Development. Journal of Trauma Nursing Asha SE, Curtis KA, Taylor C, Kwok A (2013) Patient- 19:214-220. controlled analgesia compared with interval analgesic dosing for reducing complications in blunt thoracic Curtis KA, Mitchell RJ, Chong SS, Balogh ZJ, Reed DJ, trauma: a retrospective cohort study. Emergency Medicine Clark PT, D’Amours S, Black DA, Langcake ME, Taylor CB Journal 30:1024-1028. (2012) Injury trends and mortality in adult patients with major trauma in New South Wales. Medical Journal of Blay N, Glover S, Bothe J, Lee S, Lamont F (2012) Australia 197:233. Substance users’ perspective of pain management in the acute care environment. Contemporary Nurse 42:289-297. Dinh MM, Curtis K, Ivers R (2013) The effectiveness of helmets in reducing head injuries and hospital treatment Brown MA, Roberts LM, Mackenzie C, Mangos G, Davis costs: a multicentre study. Medical Journal of Australia GK (2012) A prospective randomized study of automated 198:415, 417. versus mercury blood pressure recordings in hypertensive pregnancy (PRAM Study) Hypertension in Pregnancy Dinning PG, Hunt LM, Arkwright JW, Patton V, Szczesniak 31:107-119. MM, Wiklendt L, Davidson JB, Lubowski DZ, Cook IJ (2012) Pancolonic motor response to subsensory and Burns T (2013) Waiting for a kidney transplant in Australia- suprasensory sacral nerve stimulation in patients with slow- latest trends. Transplant Journal of Australasia 22:10. transit constipation. British Journal of Surgery 99:1002- 1010. Burns T (2013) Nutritional Management of Renal Disease. Renal Society of Australasia Journal 9:143. Dinning PG, Wiklendt L, Gibbins I, Patton V, Bampton P, Lubowski DZ, Cook IJ, Arkwright JW (2013) Low-resolution Clements A, Curtis K (2012) What is the impact of nursing colonic manometry leads to a gross misinterpretation of roles in hospital patient resuscitation? Australasian the frequency and polarity of propagating sequences: Emergency Nursing Journal 15:108-115. Initial results from fiber-optic high-resolution manometry Clohessy P, Polis S, Post J (2013) Spontaneous clearance studies. Neurogastroenterology Motility 25:e640-649. of hepatitis C virus during pregnancy. Obstetric Medicine: Dunford M, ACI-ICCMU Tracheostomy Expert Group The Medicine of Pregnancy 6:28-29. (2013) Care of Adult Patients in Acute Care Facilities with a Connell T, Fernandez RS, Tran D, Griffiths R, Harlum J, Tracheostomy Clinical Practice Guideline. Sydney: Agency Agar M (2013) Quality of life of community-based palliative for Clinical Innovation. care clients and their caregivers. Palliative Support Care Dutton M, Curtis K (2012) Well-wound therapy: use of 11:323-330. Negative Pressure Wound Therapy to prevent laparotomy Cuesta C, Blow T, Tranter S (2013) Epidermolysis bullosa: a breakdown. Journal of Wound Care 21(8) 386-388 rare challenge for peritoneal dialysis nurses. Renal Society Everett B, Salamonson Y, Trajkovski S, Fernandez R (2013) of Australasia 9:41-44. Demographic and academic-related differences between 129 standard-entry and graduate-entry nursing students: A Fry M, MacGregor C, Ruperto K, Jarrett K, Wheeler J, prospective correlational survey. Nurse Education Today Fong J, Fetchet W (2013) Nursing praxis, compassionate 33:709-713. caring and interpersonal relations: An observational study. Australasian Emergency Nursing Journal 16:37-44. Everitt L (2013) Collaboration matters: Working with ‘chaotic’ complex women: A case study. Midwifery Matters Fry M, Ruperto K, Jarrett K, Wheeler J, Fong J, Fetchet Newsletter of the Australian College of Midwives-NSW W (2012) Managing the wait: Clinical initiative nurses’ Branch Incorporated 32:14-15. perceptions of an extended practice role. Australasian Emergency Nursing Journal 15:202-210. Everitt L (2013) The experiences of midwives working with the removal of newborns for child protection concerns in Frydenberg E, Curtis K, Chong S, Poulos R, Grzebieta R, NSW, Australia: Being in the headspace and heart space. Steel T, Nau T (2012) Road trauma, patterns of injury and UTS Digital Theses Collection 1-133. mortality in an Australian trauma centre. Journal of the Australasian College of Road Safety 23:21. Everitt L (2013) Research Matters: Assumption of care of newborns in maternity units. Midwifery Matters Newsletter Graham J, Gallagher R, Bothe J (2013) Nurses’ discharge of the Australian College of Midwives-NSW Branch planning and risk assessment: behaviours, understanding Incorporated 32:10-11. and barriers. Journal of Clinical Nursing 22:2338-2346.

Fernandez R, Griffiths R (2012) Water for wound Hawkins TA, Roberts J, Mangos G, Davis G, Roberts L, cleansing. Cochrane Database Syst Rev 15 DOI Brown M (2012) Plasma uric acid remains a marker of 101002/14651858CD003861pub3. poor outcome in hypertensive pregnancy: a retrospective cohort study. British Journal of Obstetrics & Gynaecology: Fernandez R, Johnson M, Tran DT, Miranda C (2012) An International Journal of Obstetrics & Gynaecology Models of care in nursing: a systematic review. 119:484-492. International Journal of Evidence Based Health Care 10:324-337. Josland E (2013) Quality of Life. What information is already available and what evidence is this based on? Fernandez R, Rajaratnam R, Evans K, Speizer A (2012) Goal Nephrology On Line early view DOI: 10.1111/nep.12072. setting in cardiac rehabilitation: implications for clinical practice. Contemporary Nurse 43:13-21. Josland E, Brennan F, Anastasiou A, Brown MA (2012) Developing and sustaining a renal supportive care service Fernandez R, Salamonson Y, Griffiths R (2012) Emotional for people with end-stage kidney disease. Renal Society of intelligence as a predictor of academic performance in Australasia Journal, 8 (1) 12-18. first-year accelerated graduate entry nursing students. Journal of Clinical Nursing 21:3485-3492. Josland E (2013) Book review Kidney disease: From advanced disease to bereavement. Second edition. The Fernandez RS, Frost S (2013) Congruence between the Renal Society of Australasia Journal 9:142. Indian Diabetes Risk Score and Australian Type 2 Diabetes Risk Assessment tool screening in Asian-Indians. Nurse Mahashabde R, Fernandez R, Sabnis S (2013) Validity Researcher 21:36-39. and reliability of the aneroid sphygmomanometer using a paediatric size cuff for craniocervical flexion test. Fernandez RS, Tran DT, Ramjan L, Ho C, Gill B (2012) International Journal of Evidence‐Based Healthcare Comparison of four teaching methods on Evidence-based 11:285-290. Practice skills of postgraduate nursing students. Nurse Education Today Online early view. McIntosh AS, Curtis K, Rankin T, Cox M, Pang T, McCrory P, Finch C (2013) Associations between helmet use and Feild D (2013) Book Review: Understanding chronic kidney brain injuries amongst injured pedal-and motor-cyclists: A disease a guide for non-specialists. Renal Society of case series analysis of trauma centre presentations. Journal Australasia Journal 9:45. of the Australasian College of Road Safety 24:11.

Fry M, Horvat L, Roche M, Fong J, Plowes J (2012) The Mitchell R, Curtis K, Fisher M (2012) Understanding Trauma prevalence and triage characteristics of patients presenting as a Men’s Health Issue: Sex Differences in Traumatic Injury with infection to one tertiary referral hospital. Australasian Presentations at a Level 1 Trauma Center in Australia. Emergency Nursing Journal 15:127-132. Journal of Trauma Nursing 19:80-88.

Fry M, Horvat L, Roche M, Fong J, Plowes J (2013) A Mitchell R, Watson WL, Curtis K, Harris I, McDougall four month prospective descriptive exploratory study P (2012) Difficulties in establishing long-term trauma of patients receiving antibiotics in one Emergency outcomes data collections. Could trauma outcomes Department. International Emergency Nursing 21:163-167. be routinely monitored in New South Wales, Australia: 130 Piloting a 3 month follow-up? Injury 43:96-102. heterogeneity of Australian nursing students: a closer look. International Nursing Review 59:59-65. Mitchell RJ, Curtis K, Chong S, Holland AJ, Soundappan S, Wilson KL, Cass DT (2013) Comparative analysis of Sorensen R, Paull G, Magann L, Davis J (2013) Managing trends in paediatric trauma outcomes in New South Wales, between the agendas: implementing health care reform Australia. Injury 44:97-103. policy in an acute care hospital. Journal of Health Organization and Management 27:698-713. Mitchell RJ, Curtis K, Holland AJ, Balogh ZJ, Evans J, Wilson KL (2013) Acute costs and predictors of higher Taylor C, Jan S, Curtis K, Tzannes A, Li Q, Palmer C, treatment costs for major paediatric trauma in New South Dickson C, Myburgh J (2012) The cost-effectiveness of Wales, Australia. Journal of Paediatrics and Child Health physician staffed Helicopter Emergency Medical Service 49:557-563. (HEMS) transport to a major trauma centre in NSW, Australia. Injury 43:1843-1849. Moore S (2013) Management of multi-resistant organisms (MRO) in the perioperative environment study tour. Taylor CB, Curtis K, Jan S, Newcombe M (2013) Helicopter ACORN: The Journal of Perioperative Nursing in Australia Emergency Medical Services (HEMS) over-triage and the 26:18. financial implications for major trauma centres in NSW, Australia. BMC Emergency Medicine 13:11. Morris P (2013) Understanding the experience of a cancer diagnosis and illness--A patient perspective of the Tranter S, Anastasiou A, Bazzi H, Burgess H, Josland biographical disruption of multiple myeloma. Australian E (2013) The renal memorial service: an important Journal of Cancer Nursing 14:20. component of renal supportive care. Renal Society of Australasia Journal 9:80-84. Moustakas J, Bennett P, Tranter S, Nicholson J (2012) The needs of older people with advanced chronic kidney Wang DH, Blenman N, Maunder S, Patton V, Arkwright disease choosing supportive care: a review. The Renal J (2013) An optical fiber Bragg grating force sensor for Society of Australasia Journal 8:70-75. monitoring sub-bandage pressure during compression therapy. Optics Express 21:19799-19807. Munroe B, Curtis K, Considine J, Buckley T (2013) The impact structured patient assessment frameworks have Westgarth F, Chiarella M, Tranter S (2012) The on patient care: an integrative review. Journal of Clinical haemodialysis Models of care Program. The Renal Society Nursing 22:2991-3005. of Australasia Journal 8:24-31.

Ogilvie R, McCloughen A, Curtis K, Foster K (2012) The Willenberg L, Curtis K, Taylor C, Jan S, Glass P, Myburgh experience of surviving life‐threatening injury: a qualitative J (2012) The variation of acute treatment costs of trauma synthesis. International Nursing Review 59:312-320. in high-income countries. BMC Health Services Research 12:267. Patton V, Wiklendt L, Arkwright JW, Lubowski DZ, Dinning PG (2013) The effect of sacral nerve stimulation on distal Wiseman T, Foster K, Curtis K (2013) Mental health colonic motility in patients with faecal incontinence. British following traumatic physical injury: An integrative literature Journal of Surgery 100:959-968. review. Injury 44:1383-1390.

Pianta TJ, Horvath AR, Ellis VM, Leonetti R, Moffat C, Presentations at Conferences and Meetings Josland EA, Brown MA (2012) Cardiac high‐sensitivity troponin T measurement: A layer of complexity in Abraham E, Patton V, Lutton N, Lubowski D (2012) The managing haemodialysis patients. Nephrology 17:636- cutting seton. Annual Scientific Congress, RACS Kuala 641. Lumpur, Malaysia.

Rolley J, Fernandez R, Everett B, Mohan S, Davidson PM Abraham E, Patton V, Lutton N, Lubowski D (2012) Sacral (2012) Factors associated with dietary practices and heart nerve stimulation for faecal incontinence - our institution’s disease prevention among Indian Australians: a focus experience. Annual Scientific Congress, RACS Kuala group study. Heart, Lung and Circulation 21:S308. Lumpur, Malaysia.

Rolley J, Fernandez R, Everett B, Mohan S, Davidson PM Ajami A (2012) The First Aid Skills Training (FAST) Project. (2012) Perceptions of medication taking among Asian Multicultural health research to practice forum: St George Indian Australians: a focus group study. Heart, Lung and Hospital, NSW. Circulation 21:S312. Ajami A, Chan DT (2012) Medical Assessment and Salamonson Y, Ramjan L, Lombardo L, Lanser LH, Decision Making in Emergency (MADMEN) Project. Fernandez R, Griffiths R (2012) Diversity and demographic Australasian Redesigning Healthcare Summit, Brisbane.

131 Awad S, Cooper N, Department E (2013) ED Versus the Curtis K (2013) Keynote speaker 8th Annual Critical Care Ward. Can secondments improve clinician relationship Conference Vineyards, Hunter Valley, NSW. and development of knowledge and skills. Council Curtis K (2012) 2012 Vision, Challenges, and New Frontiers of Children’s Nurses Conference: Winds of Change: in Emergency Care. 10th International Conference for Homebush, NSW. Emergency Nursing: Hobart. Brown M, Collett G, Josland E, Brennan B (2013) Non- Curtis K (2013) Management of massive haemorrhage in dialysis management in the elderly: survival, sympton trauma. International Conference for Emergency Nurses: control and quality of life. ASN Kidney Week: Atlanta Melbourne. Georgia USA. Burns, L (2012) Curtis K, Chan D (2013) . The injury profile and acute Burns, L (2012) Minimal Space, No Extra Nurses but Lots treatment costs of major trauma in older people in of Patients – Finding a New Way to Increase Capacity. New South Wales. Trauma Surgery Section of the Royal Haematological Society of Australia and New Zealand, Australasian College of Surgeons Annual Scientific Melbourne November. Congress: Auckland, New Zealand. Burns, L (2012) Minimal Space, No Extra Nurses but Lots Curtis K, Clements A, Curtis K, Holzhauser K, Horvat L of Patients – Finding a New Way to Increase Capacity. (2012) The impact of a senior nurse as nurse team leader (Presentation & Poster) National Health Roundtable on communication and perceptions of leadership in major Innovation Awards, October 2012. Sydney, Australia trauma resuscitations. Trauma 2012 Conference: Perth. (Winner of National Innovator of the year, nominated for a Premier’s award 2012). Curtis K, Clements A, Holzhauser K, Horvat L (2012) The impact of a senior nurse as nurse team leader on Burns L, Morris K (2012) Improving the Cancer Journey – communication and perceptions of leadership in major Introduction of a Nurse-Run Clinic for Patients Finishing trauma resuscitations. 10th International Conference for Treatment for Cancer. The Annual Scientific Meeting of the Emergency Nursing: Hobart. HAA (Haematology Society of Australia and New Zealand, HSANZ, the Australian & New Zealand Society of Blood Curtis K, Crouch R, Palfrey R, McHale H (2013) Trauma Transfusion, ANZSBT, and the Australasian Society of Nurse Coordinators in England Major Trauma Coordinator Thrombosis and Haemostasis - ASTH) and the Asian-Pacific National Conference: Salford, England. Society on Thrombosis and Haemostasis: Melbourne Curtis K, Dutton M, Chiarella M (2012) The current state Burns T, Fernandez R, Stephens M (2013) Waiting for a of knowledge into role, context of practice and impact of kidney transplant - a literature review. Transplant Nurses of the wound care nurse. 4th Congress of the World Union Australasia Annual Conference Sydney, NSW. of Wound Healing Societies Better Care, Better Life: Yokohama Japan. Chandrasekhar J, Paull G, Youssef G, Weaver J, Rees D (2012) Single Centre Clinical Experience and Discharge Curtis K, Dutton M, Chiarella M (2012) The current state planning using high sensitivity troponin T post Elective of knowledge into role, context of practice and impact of PCI. 60th Annual Scientific Meeting of Cardiac Society of the wound care nurse. 10th National Australian Wound Australia and New Zealand Brisbane. Management Association Conference: Sydney Convention & Exhibition Centre. Cryer J.A (2012) Ten years on and still going strong. International Cancer Nurses Conference: Prague. Curtis K, Frydenberg E, Chong S, Poulos R, Grzebieta R, Steel T, Nau T (2012) Road Trauma, Patterns of Injury and Cuesta A, Tranter, S. & Blow, T (2012) Caring for a Mortality in an Australian Trauma Centre. Neurosurgery patient with Epidermolysis Bullosa on Peritoneal Dialysis. Section of the Royal Australasian College of Surgeons’ Renal Society of Australasia 40th Annual Conference: Annual Scientific Congress: Kuala Lumpur, Malaysia. Melbourne, VIC. Curtis K, Kennedy B, Waters D (2013) The Personality Cuesta A (2013) Addressing Peritoneal Dialysis Related Characteristics of Emergency Nurses. International Infection. Nephrology workshop: Sydney, NSW. Conference for Emergency Nurses: Melbourne. Cuesta A, Tranter S, Blow T (2013) Taking control: Curtis K, Lam M, Mitchell R, Black D, al e (2012) Acute addressing peritoneal dialysis related infection outcomes. costs and predictors of higher treatment costs of trauma Renal Society of Australasia Conference: Hobart. in New South Wales, Australia. Trauma 2012 Conference: Curtis K (2012) Invited speaker – case reviews. Swan XX Perth. Trauma Conference: Sydney.

132 Curtis K, Leonard E (2012) A snapshot: Resources currently Decker V (2013) Regular Interprofessional Simulation available in trauma services throughout Australia and New Cases. STG POWH ICU Symposium Sydney. Zealand. Trauma 2012 Conference: Perth. Dinning P, Patton V, Hunt L, Gebski V, Jones M, Stewart Curtis K, Mitchell R, al. e (2013) Acute care costs and P, Lubowski D, Cook I (2013) Efficacy of sacral nerve predictors of higher treatment costs for major paediatric stimulation for severe slow transit constipation -a trauma in NSW. 11th Australasian Injury Prevention & randomised double-blind placebo-controlled crossover Safety Promotion Conference: Fremantle, WA. study. . American Society of Colon and Rectal Surgeons Annual Meeting: Phoenix Arizona. Curtis K, Mitchell RJ, Chong S, Balogh ZJ (2012) Injury trends and mortality in adult patients with major trauma Everitt L (2012) Assumption of Care. St George / in NSW. 10th International Conference for Emergency Sutherland Hospitals & Health Services (SGSHHS) Annual Nursing: Hobart. Midwifery Seminar Working Together: Kogarah.

Curtis K, Mitchell RJ, Chong S, Balogh ZJ (2012) Injury Everitt L (2012) Learning to play the hard course: Midwives trends and mortality in adult patients with major trauma in role in assumption of care of newborns. Australian College NSW. Trauma 2012 Conference: Perth. Midwives – NSW Branch Inc. Annual State Conference: Wyong, NSW. Curtis K, Mitchell RJ, Chong S, Balogh ZJ (2013) Injury trends and mortality in adult patients with major trauma Everitt L, Homer C, Fenwick J (2012) Midwives Experience in New South Wales, Australia. Unlocking the Value of of Working with Community Services during Assumption Mortality Data Workshop: Sydney. of Care of Newborns. 4th Biennial Breathing New Life into maternity Care Multidisciplinary Conference: Melbourne, Curtis K, Munroe B, Curtis K, Buckley T, Considine J Victoria. (2012) The impact of a structured patient assessment on patients and clinicians. 10th International Conference for Everitt L, Homer C, Fenwick J (2013) Assumption of Care Emergency Nursing: Hobart. of a Newborn: How can you be prepared? Australian College of Midwives, 18th National Conference: Hobart, Curtis K, Ogilvie R, Palmer C, Lam M, McCloughen Tasmania. A, Foster K (2013) Incidence and outcomes of major traumatic injury in the Australian Capital Territory. Everitt L, Lock K, Fenwick J, Homer C (2012) Breastfeeding Canberra Health Annual Research Meeting (CHARM): and assumption of care of newborns. . The Inaugural Canberra, ACT. Lactation Consultants of Australia and New Zealand (LCANZ) Conference Sydney, NSW. Curtis K, Ogilvie R, Palmer C, Lam M, McCloughen A, Foster K (2013) Incidence and outcomes of major Griffith J (2012) Understanding 1:1 midwifery care. NSW traumatic injury in the Australian Capital Territory. Health Towards Normal Birth State-wide Workshop: International Conference for Emergency Nurses: Sydney, NSW. Melbourne. Griffith J (2013) Rural maternity: what’s so different? UTS Curtis K, Wiseman T, Foster K (2013) The incidence of Bachelor of Midwifery (Year 3) Day: Sydney, NSW. depression, anxiety and stress (DAS) in trauma patients Griffith J, Best P (2012) Ways of Working in Maternity Care. during hospital admission and 3 months post injury. St George Midwifery Conference: Kogarah, NSW. Queensland Trauma Symposium Brisbane, QLD. Griffith J, Best P (2012) Ways of Working in Maternity Care. Davis G, Roberts L, Mangos G, Brown M (2012) The UM- SESLHD Executive Forum: Randwick, NSW. 101 mercury-free sphygmomanometer: a replacement for mercury sphygmomanometry at last? XVIII ISSHP World Hodges K, Jones S (2013) Multidisciplinary ward round Congress: Geneva, Switzerland. project. STG POWH ICU Symposium Sydney.

Davis S, Paull G, Vuong N, Connolly B, Ang E (2012) Horvat L, Fry M, Plowes J, Fong J (2012) To explore the ICD’s and PTSD: a shocking story - from crisis to recovery. nursing assessment and initial management of septic Australian Cardiovascular Health and Rehabilitation patients in the Emergency Department. Annual Critical Association Conference Kirribilli, NSW. Care Conference Hunter Valley, NSW.

Davis S, Paull G, Vuong N, Connolly B, Ang E (2012) Jacques E (2012) HCC Nurse Coordinator: Impact on ICD’s and PTSD: a shocking story - from crisis to recovery. MDT Model and Patient Education. 8th Australasian Viral Australian Cardiovascular Health and Rehabilitation Hepatitis Conference: Auckland, NZ. Association Conference: Brisbane, QLD.

133 Jones S (2013) Pressure injury prevention for critically ill Meek C (2013) Transitioning onto Haemodialysis - patients Guidelines. The ACI Intensive Care Coordination Evaluating the effectiveness of a new educational and Monitoring Unit (ICCMU): Sydney. resource. Renal Society of Australasia Annual Conference: Hobart, TAS. Josland E (2012) Hepatitis Protocols: Opening a can of worms. RSA 40th Annual Conference: Melbourne, VIC. Modester T (2012) Fractured Neck of Femur. Australian Orthopaedic Nurses’ Association Annual Conference: Josland E (2012) Renal Supportive Care: Holistic care Homebush, NSW. for ESKD patients and their families. RSA 40th Annual Conference: Melbourne, VIC. Moore S (2012) Perioperative Management of Patients with MROs Centre for Infectious Diseases and Josland E, Collett G, Brennan F, Foote C, Brown M (2012) Microbiology Public Health Conference Westmead HOPE: Helping Older People with ESKD. International Hospital, Sydney Australia. Forum on Quality and Safety in Healthcare: Le Palais des Congress, Paris, France. Moore S (2012) Understanding Health Fund Contracts. Day Surgery Nurses Association State Conference: Sydney, Keating L (2013) Measurement of temperature in critically Australia. ill adults: A systematic review and clinical practice guideline. . The Australian and New Zealand Intensive Moustakas J, Bennett P, Tranter S, Nicholson J (2012) Care Society (ANZICS) Conference: Hobart, Tasmania. Supportive care: what does the patient want? Renal Society of Australasia 40th Annual Conference: Keating P (2013) Manual Handling Equipment in St Melbourne, VIC. George Hospital. Statina International Conference: Homebush Sydney. Patton V (2012) Antegrade colonic enema administered via Chait Cecostomy Catheter. World Council of Enterostomal Keating P (2013) Perioperative Introduction Programme to Therapists: Adelaide . Tongan Nurses. Orthopaedic Outreach: Tonga. Patton V (2013 ) Are anorectal physiology tests useful in Kennedy B (2013) Personality Characteristics of Emergency asymptomatic primiparous patients with OASIS obstetric Nurses College of Emergency Nursing Australasia (CENA) anal sphincter injuries? Royal Australian and New Zealand Conference: Melbourne. College of Obstetricians and Gynaecologists 2013 Annual Lafferty M (2012) Improving care in RACF - a Model to Scientific Meeting (RANZCOG 2013 ASM): Sydney, NSW. improve care and communication- NSW Palliative care Patton V, Dinning P, Lubowski DZ, Arkwright J, King NSW Palliative Care Dubbo. D (2012) Colonic manometry demonstrates the mode Lock K (2013) Vulnerable Population groups: Innovative of action of sacral nerve stimulation in patients with Models of Care at two Baby Friendly Health Accredited faecal incontinence Joint International Meeting in hospitals. International Lactation Consultant Association Neurogastroenterology and Motility Bolongna Italy. Conference: Melbourne, Victoria. Patton V, Lubowski D (2012) Sacral nerve stimulation Magann L (2012) Benefits of early referral to palliative modifies colonic motility in patients with faecal care, symptom management and end of life conversations incontinence. International Society of University Colon and Australian Hepatoly Summit: Sydney. Rectal Surgeon (ISUCRS) Congress: Bologna.

Martinez-Smith Y, Meek C (2012) “Collaboration in Care”. Patton V, Lubowski D (2013) Antegrade colonic enema via Home Therapies Workshop: Sydney, NSW. a Chait caecostomy catheter - is it a viable option for adult bowel management?, American Society of Colon and Martinez-Smith Y, Meek C (2012) Oral presentation – Rectal Surgeons Annual Meeting: Phoenix Arizona. “Collaboration in Care”. Home Therapies Workshop: Sydney, NSW. Patton V, Lubowski D (2013) Sacral nerve stimulation for slow transit constipation. St George Medical Research McCarthy F, Falomir C (2012) Solution to safe storage. Conference Sydney, NSW. Innovation in work health and Safety: St George Hospital, Sydney. Patton V, Lubowski D (2013) Sacral nerve stimulation: why do patients fail PNE? American Society of Colon and Meek C (2013) Safeguarding veins – the use of a Save Rectal Surgeons Annual Meeting: Phoenix Arizona. the Vein Tattoo. Renal Society of Australasia Annual Conference: Hobart. Paull G (2012) Self-management: Multilingual Audio-visual Resources for People with Ischaemic Heart Disease and Chronic Heart Failure Australasian Cardiovascular Nursing College, The Ageing Heart Conference: Sydney, NSW. 134 Paull G, Gallagher R, Horvath R, Chen D (2012) escalation of delays in order to facilitate patient flow within Discrimination and high sensitivity cardiac troponin: the ED. Annual Critical Care Conference Hunter Valley, NSW relationship between clinical presentation, clinical request Romero B, Ajami A, Bayeh G, Neuhaus L, Foreshew M, and discharge diagnosis. 60th Annual Scientific Meeting Cosgrove J (2012) To identify delay reasons for Ed patients of Cardiac Society of Australia and New Zealand Brisbane, at 4 and 8 hours allowing the early identification and QLD. escalation of delays in order to facilitate patient flow within Polis S, Matisan A, Mainali B, al e (2012) Patient ED. Annual Critical Care Conference: Hunter Valley, NSW. adherence to lactulose to minimise the risk of Hepatic Sorensen R, Paull G, Magaan L, Davis J (2012) Is poor Encephalopathy. 8th Australasian Viral Hepatitis quality of care built into the system? Evidence from a study Conference Auckland, New Zealand. on communication among teams treating people dying Polis S, Wheeler E, Richmond J (2012) Developing in hospital 8th International Organisational Behaviour in Hepatitis B virus education for registered nurses. Healthcare Conference - Patient-centred healthcare teams: Australasian Viral hepatitis Conference: Auckland, New achieving collaboration, communication and care: Dublin, Zealand. Ireland.

Polis S, Wheeler E, Richmond J (2012) Evaluation Speizer A, Fernandez R (2012) Goal setting in cardiac of Hepatitis B Virus education for registered nurses. rehabilitation: Implications for clinical practice. The Australasian Viral hepatitis Conference: Auckland, New Australian Cardiovascular Health and Rehabilitation Zealand. Association Conference Brisbane.

Polis S, Zekry A, Maher L (2012) Adherence to anti-viral Szwajcer A (2012) Supporting Young Women with Breast medications: a qualitative study. Australasian Viral hepatitis Cancer. International Cancer Nurses Conference: Prague. Conference: Auckland, New Zealand. Tranter S (2013) Management of CKD Innovative Reilly A, Everitt L, Murray N (2013) Young Mum’s Group: approaches to best practice: chronic disease management Unexpected Lessons. Australian College of Midwives, 18th in the Community workshop - GP NSW: Sydney, NSW. National Conference: Life, Art and Science in Midwifery: Tranter S, Josland E (2013) Association of nutritional Hobart, Tasmania. status and the future choice of dialysis option in patients Roberts L (2012) Hypertension in pregnancy- practice attending the multidisciplinary predialysis assessment and evidence. Australian College of Midwives National clinic. Renal Society of Australasia Conference: Hobart. Webinar Series. Tranter S, Josland E (2013) Nutritional profile of patients at Roberts L, Davis G, Mangos G, Brown M (2012) The UM- enrolment to the multidisciplinary predialysis clinic 2002- 101 mercury-free sphygmomanometer: a replacement 2012. Renal Society of Australasia Conference: Hobart. for mercury sphygmomanometry at last? St George and Turner K, Burns T (2013) The role of a renal transplant Sutherland Medical Research Foundation Symposium: recipient coordinator in a non-transplanting unit. Kogarah, NSW. Transplant Nurses of Australasia Annual Conference Robertson F (2012) Breastfeeding and High Risk Sydney, NSW. Pregnancy. Annual St George Breastfeeding Conference: Manning, V (2012) To NUM or not to NUM – that is the Kogarah, NSW. question? Leadership and Practice Development in Rolley J, Fernandez R, Everett B, Mohan S, Davidson Health: Quality and Safety through Workplace Learning P (2012) Factors Associated with Dietary Practices and Conference: Hobart. Heart Disease Prevention Among Indian Australians: A Walter L (2013) Impact from point of care devices Focus Group Study. Cardiac Society of Australia and New on emergency department patient processing times Zealand: Brisbane. compared with central laboratory testing of blood Rolley J, Fernandez R, Everett B, Mohan S, Davidson P samples: a randomised controlled trial and cost- (2012) Perception of Medication Taking Among Asian effectiveness analysis. International Conference of Indian Australians: A Focus Group Study. Cardiac Society Emergency Nursing: Melbourne. of Australia and New Zealand: Brisbane.

Romero B (2012) The emergency flow Coordinator International Conference of Emergency Nursing: Hobart.

Romero B (2012) To identify delay reasons for ED patients at 4 and 8 hours allowing the early identification and 135 SOUTH EASTERN SYDNEY LABORATORY SERVICES

Anatomical Pathology > 137 > Anatomical Pathology (SEALS) St George Hospital

Head of Department AL.Biomarkers of therapeutic response to tamoxifen in ER+ breast cancer in the context of IBCSG Trials VIII and Dr Con Theocharous MBBS FRCPA, Conjoint Lecturer IX. $50,000. 2010-2012. UNSW Illawarra Health and Medical Research Institute small Senior Medical project grant. V Ramachandran, J McArthur, Sanderson- Dr Leon Vonthethoff MBBS FRCPA Smith, R Sluyter, M Lonergan, EKA Millar.Development of Dr Veli Marjoniemi MBBS BSc FRCPA, Conjoint Senior an inducible animal model for acute post-streptococcal Lecturer UNSW glomerulonephritis. Total awarded: $10,000. 2012. Dr Kim Tran MBBS FRCPA, Conjoint Lecturer UNSW Original Peer-Reviewed Publications Dr Jill Griffith BMed(Hons) FRCPA Dr Louella Davey MBBS FRCPA 2012 A/Prof Ewan Millar BSc(Hons) MBChB FRCPath FRCPA MD FFSc(RCPA), Conjoint Assoc Prof UNSW & UWS; Visiting Coates AS, Millar EKA, O’Toole S, Musgrove E, Viale G, Pathologist Kinghorn Cancer Centre & Garvan Institute of Regan M, Goldhirsch A, Gelber RD, Price KN, Castiglione- Medical Research. Gertsch M, Sutherland RL. Qualitative prognostic interaction between immunohistochemical expression of Research Staff p53 and estrogen receptor in patients with node-negative breast cancer. Results from International Breast Cancer Julia Beretov BSc DipEd (hospital scientist & PhD Study Group Trials 8 and 9. Breast Cancer Res. 2012 Nov candidate) 5;14(6):R143. Wei Melbourne MSc (hospital scientist) Chow HT, Tran K, Millar EKA, Lynch J, Murrell DM. Diverse Research Grants presentations of carcinoma erysipelatoides. Case reports NHMRC Program Grant ID No: 535903 in dermatological medicine 2012:134938. Principal investigators Daly RJ, Horvath LG, Millar EKA, Hao J, Madigan MC, Khatri A, Power CA, Hung TT, Ormandy CJ, Kench JG, O’Toole SA. Beretov J, Chang L, Xiao W, Cozzi PJ, Graham PH, Project title Molecular markers of phenotype, therapeutic Kearsley JH, Li Y. In vitro and in vivo prostate cancer responsiveness and prognosis in human cancers. Total metastasis and chemoresistance can be modulated by awarded: $11,128,320. 2009-2013. expression of either CD44 or CD147. PLoS One. 2012;7(8)

Cancer Australia Project Grant 626201 Wei Melbourne, Kim Tran , Loreena Johnson , Paul de Investigators: Graham PH, Delaney G, Millar EKA, Capp Souza , William J. Lynch. hENT1 expression in human A. A Randomised comparison of anastrozole commenced urothelium; Evaluating hENT1 prognostic potential for before and continued during adjuvant radiotherapy for intravesical Gemcitabine treatment come in patients with breast cancer versus anastrozole and subsequent anti- superficial urothelial carcinoma. BJUI, vol 109, supple 4 oestrogen therapy delayed until after radiotherapy (STARS April 2012. - Study of Anastrozole and Radiotherapy Sequencing), $660,000. 2010-2012. 2013

Cancer Institute NSW Translational Program Grant 10/ O’Toole, Beith J, Millar EKA, West R, McLean A, Cazet A, TPG/1-04. Investigators: Horvath L, Kench J, Boyer M, Swarbrick A, Oakes S. New therapeutic targets in triple Millar E, O’Toole S, Beith J and Grimison P. Personalised negative breast cancer. Journal of Clinical Pathology. medicine for cancer: molecular biomarkers in clinical 2013. 66(6):530-42. decision making for breast, prostate and pancreatic cancer. C Wolford, M Leon, A Merchant, X Yin, S Jalgaonkar, Y $3,714,000. 2010-2014. Seok Chang, J Dominick, S McConoughey, E Zmuda, ANZ Breast Cancer Trials Group. Investigators: Sutherland SA O’Toole, EKA Millar, CL Shapiro, M Ostrowski, RL RL, O’Toole SA, Millar EKA, Musgrove EA, Coates Sutherland, T Hai. ATF3 links host adaptive-response 137 to breast cancer metastasis. J Clin Invest. 2013 Jul Urothelial Carcinoma – A translational study of potential 1;123(7):2893-906. predictive biomarkers, MSc Thesis (UNSW).

Browne BC, Hochgräfe F, Wu J, Millar EK, Barraclough Presentations at Scientific Meetings and J, Stone A, McCloy RA, Lee CS, Roberts C, Ali NA, Conferences Boulghourjian A, Schmich F, Linding R, Farrow L, Gee JM, Nicholson RI, O’Toole SA, Sutherland RL, Musgrove 2012 - International EA, Butt AJ, Daly RJ. Global characterization of signalling EKA Millar, Intrinsic subtype and its clinical significance networks associated with tamoxifen resistance in breast in early node negative breast cancer: results from two cancer. FEBS J. 2013 280(21):5237-57. randomized trials of adjuvant chemoendocrine therapy. Tiu A, Reynolds R, Millar EKA, Aslan P. Neuroblastoma American Society of Clinical Oncology (ASCO) Annual of the adult kidney, the report of a case. Urology. 2013 Meeting, Chicago, USA, June. Jul;82(1):11-3. EKA Millar, Sydney International Breast Cancer Conference Hau E, Browne L, Capp A, Delaney G, Fox C, Kearsley 2012: “Basal-like breast cancer”. Sydney, October 24-26. JH, Millar EKA, Nassar EH, Papadatos G, Graham PH: The 2012 - National impact of breast cosmetic and functional outcomes on quality of life: long term results from the St George and Wei Melbourne, Kim Tran, Loreena Johnson, Paul de Wollongong Randomized Breast Boost Trial. Breast Cancer Souza, William J. Lynch. hENT1 expression in human Res Treat. 2013;139(1):115-23. urothelium; Evaluating hENT1 prognostic potential for intravesical Gemcitabine treatment come in patients with Schade B, Lesurf R, Sanguin-Gendreau V , Millar EKA, superficial urothelial carcinoma 65Th Annual Scientific Zardawi SJ, Lopez-Knowles E, Sutherland RL, O’Toole meeting Darwin April. SA, Kahn M, Hallett M, Muller WJ. Targeting B-catenin signaling in ErbB2-driven breast cancer impairs 2013 - International metastasis and expression of ErbB2. Cancer Res. 2013; 15:73(14):4474-87. Wei Melbourne, Kim Tran, Dedee F. Murrell. Collagen VII monoclonal antibodies in the diagnosis of dystrophic Ni J, Cozzi P, Hao J, Beretov J, Chang L, Duan W, Shigdar epidermolysis bullosa by immunofluorescence mapping. S, Delprado W, Graham P, Bucci J, Kearsley J, Li Y. Beijing China BIT’s 5th Annual Internation Congress of Epithelial cell adhesion molecule (EpCAM) is associated Antibodies (ICA-2013). with prostate cancer metastasis and chemo/radioresistance via the PI3K/Akt/mTOR signaling pathway. Int J Biochem Cohn HI; Tran K; Chow CW; Palmer E; Turner A; South Cell Biol. 2013 Dec;45(12):2736-48. AP; Murrell DF, 2013, ‘A novel mutation in COL7A1, G2269R causing nail only DDEB and RDEB, with a Venugopal SS1, Yan W, Frew JW, Cohn HI, Rhodes LM, presentation similar to TBDN at birth when coinherited Tran K, Melbourne W, Nelson JA, Sturm M, Fogarty J, with R2814X COL7A1 mutation’, in Journal of investigative Marinkovich MP, Igawa S, Ishida-Yamamoto A, Murrell dermatology, NATURE PUBLISHING GROUP, pp. DF. A phase II randomized vehicle-controlled trial of S141 - S141, presented at International Investigative intradermal allogeneic fibroblasts for recessive dystrophic Dermatology Meeting, Edinburgh, Scotland, 8 - 11 May. epidermolysis bullosa. J Am Acad Dermatol. 2013 Dec;69(6):898-908.e7. doi: 10.1016/j.jaad.2013.08.014. Yan WF; Venugopal SS; Frew JW; Rhodes LM; Melbourne Epub 2013 Sep 24. W; Tran K; Murrell DF, 2013, ‘Translocation of the cytokine HMGB1 coincides with wound healing in fibroblast- Other Published Material injected wounds of recessive dystrophic epidermolysis bullosa’, in Journal Of Investigative Dermatology, EKA Millar, Studies on biomarker development in breast Nature Publishing Group, pp. S137 - S137, presented cancer. MD Thesis (UNSW). at International Investigative Dermatology Meeting, Wei Melbourne, Immunohistochemistry of Superficial Edinburgh, Scotland, 8 - 11 May. 138 AGED AND EXTENDED CARE

Aged Care, St George Hospital > 140

Rehabilitation Medicine, > St George Hospital 141

Southcare, The Sutherland Hospital > 142 > Department of Aged Care St George Hospital

Head of Department Research Grants

Peter Smerdely MBBS (Hons) MPH PhD FRACP St George & Sutherland Medical Research Foundation. Senior Staff Specialist Geriatric Medicine & Endocrinology The Impact of Routine Post-Discharge Medical Evaluations Director Department of Aged Care, St George Hospital of Nursing Home Patients Following Acute Hospital Co Director, Aged & Extended Care, St George and Admissions. Chief Investigator Dr Nicholas Cordato. Sutherland Hospitals Health Service, Network Executive $50,000, 2012. Clinical Director, Conjoint Associate Professor UNSW Research Projects in Progress Senior Medical, Geriatric Medicine The Impact of Routine Post-Discharge Medical Evaluations Litsa Morfis, MBBS FRACP of Nursing Home Patients Following Acute Hospital Staff Specialist, Geriatric Medicine Admissions. Chief Investigator Dr Nicholas Cordato. Conjoint Lecturer, UNSW The 4AT Study: Screening for Delirium in an Elderly Chris Dedousis, MBBS FRACP Hospital Population. Dr Jayita De, Dr Anne Wand, Senior Staff Specialist, Geriatric Medicine & Thoracic Professor Peter Smerdely Medicine Conjoint Appointment with Southcare, Sutherland Presentations at Scientific Meetings and Hospital, Conjoint Senior Lecturer, UNSW Conferences

Sarah Baldwin MBBS FRACP Cordato, N. Invited Platform Presentation. The Staff Specialist, Geriatric Medicine, Conjoint Lecturer, Extrapyramidal Spectrum. Australian and New Zealand UNSW Society for Geriatric Medicine ANZSGM Annual Scientific Meeting 2012, Sydney. Tony Youssef BSc (MED) MBBS FRACP Staff Specialist, Geriatric Medicine Community Engagement Conjoint Appointment with Southcare, Sutherland Hospital All staff members are actively involved with the Nicholas Cordato, MBBS (Hons 1) FRACP PhD community. Regular lectures are given to groups auspiced Senior Staff Specialist, Geriatric Medicine by Alzheimer’s Australia, Department of health and St Conjoint Appointment with CRAGS, Calvary Hospital, George Hospital. Conjoint Senior Lecturer, UNSW, “Delirium Care: What You Need to Know”, Flip Chart Grant Pickard MBChB FRACP Staff Educational Resource. Developed collaboratively Staff Specialist, Geriatric Medicine with Associate Professor Victoria Traynor, the University of Appointed to Medical Assessment Unit Wollongong.

Yun Xu MBBS FRACP Peter Smerdely - Member, SESLHD Board. Staff Specialist, Geriatric Medicine Appointed to Medical Assessment Unit Nicholas Cordato - Senior Research Fellow, Neurosciences Conjoint appointment with CRAGS, Calvary Hospital Research Australia, Randwick.

Louise Baird MBBS FRACP Conjoint Lecturer, UNSW Staff Specialist, Geriatric Medicine Appointed to Medical Assessment Unit & Aged Care

Kannie Chuang MBBS FRACP Staff Specialist, Geriatric Medicine Appointed to General Medicine Unit

140 > Department of Rehabilitation Medicine St George Hospital

Head of Department Research Projects in Progress

Dr John Estell MBBS, BS, MSpMed, FAFRM(RACP) Cost Benefit of Rehabilitation Care John Estell and Kenneth Chan. Senior Medical On-Site versus Off-site Rehabilitation in Stroke Dr Scott Hannan MBBS, BMedSci, FAFRM(RACP) FACRM John Estell. Conjoint Senior Lecturer UNSW On-Site versus Off-site Rehabilitation in Orthopaedic Dr Kenneth Chan MBBS, BSc(Med) FAFRM(RACP) Conditions, John Estell. Dr Brenda Slee MBBS MPH FAFRM(RACP) Interventional Spasticity Management A/Professor Andrew Cole MBBS(Hons) FAFRM(RACP) Scott Hannan, Brenda Slee and John Estell. FACRM Conjoint Associate Professor, School of Rehabilitation Intensity of Therapy Community Medicine UNSW John Estell.

Acute Rehabilitation Intervention in Trauma (multicentre

study coordinated through St Vincent’s Hospital) John

Estell.

Original Peer-Reviewed Publications

Poulos, CJ., Eagar, K., Faux, SG., Estell, JJ & Crotty, M. (2013). Subacute care funding in the firing line. Medical Journal of Australia, 199 (2), 92-93.

Presentations at Scientific Meetings/ Conferences 2013 International

John Estell, Justine Tinker. Best Practice Learning – the Australian Experience, Regional Spasticity Education Conference Seoul Korea, June.

John Estell, Spasticity Management and its Impact on

Function. Excellence in Spasticity Management, Asia-

Pacific Conference. Seoul, South Korea, June.

2013 National

John Estell, Sub Acute Models of Care, Australasian Faculty of Rehabilitative Medicine Conference, Sydney.

Kenneth Chan, On-site vs Off-site Stroke Rehabilitation

– which is more cost effective, Australasian Faculty of

Rehabilitative Medicine Conference, Sydney.

141 > Southcare, Sutherland Hospital and Community Services

Head of Department Research Projects in Progress A/Prof Peter Gonski MBBS BMedSci FRACP conjoint A/Prof UNSW VAPOUR study- A Controlled Trial of Vertebroplasty for Acute Painful Osteoporotic FractURes. Senior Medical William.Clark, Terry Diamond, Patrick McNeil; Peter Nyein Nyein Nyi Nyi MBBS FRACP Gonski; Peter Smerdely; Glen Schlaphoff; Derek Glenn; Chris Dedousis MBBS FRACP John Rouse; Paul Bird; Chris Dedousis. Stephen Phoon MBBS FRACP INSPIRED study- Improving Service Provision for Early Bethlyn Gill MBBS FRACP Onset Dementia. Philip Conroy MBBS FRACP Brian Draper; Henry Brodaty; Adrienne Withall; Prasad Lucy Ramon MBBS FAFRM (RACP) Nishtala; John Hodges; Peter Gonski; Clement Loy; Shikha Jain MBBS FRACP Colleen Mckinnon; Julian Trollor ; Perminder Sachdev ; Tony Youssef BSc(Med) MBBS FRACP Christopher Poulos; Robert Cumming; Bruce Brew. Research Staff Rehabilitation Heel Injury Prevention Project Ms A.Stewart CNC Ann Stewart. Original Peer-Reviewed Publications Gonski PN, Moon I. Outcomes of a Behaviour Unit in an Aged care Service Arch Gerontol Geriatr 2012,55:60-65. Gonski P, Ye X. Fractures related to falls in older patients attending an Emergency Department Australasian Journal on Ageing 2013,32 (1):64-66.

Presentations at Scientific Meetings and Conferences 2012 National

Gonski PN, Why I prescribe medications for dementia. ANZSGM Scientific meeting Sydney.

142 ALLIED HEALTH

Nutrition and Dietetics > 144

Occupational Therapy > 146

Physiotherapy > 147

Speech Pathology > 148

143 > Nutrition and Dietetics, St George Hospital

Head of Department Avesani CM, Trolonge S, Deleaval P, Baria F, Mafra D, Faxen-Irving G, Chauveau P, Teta D, Kamimura MA, Janet Bell (BSc, M NutDiet), Honorary Senior Fellow - Cuppari L, Chan M, Heimburger O and Fouque D. Illawarra Health and Medical Research Institute, School of Physical activity and energy expenditure in haemaodialysis Medicine, University of Wollongong patients: an international survey. Nephrol Dial Dietitians Transplantation. 2012 Jun;27(6):2430-4.

Maria Chan, PhD, (awaiting to be conferred), BSc(Hons) Chan M, Nutrition, diabetes and chronic kidney disease, MNutDiet GradDipExSpSc AdvAPD, Senior Renal Australian Diabetes Educator Volume 15 Number 3, Dietitian, Conjoint Associate Lecturer - St. George Clinical August 2012, 17-23. School, School of Medicine, University of New South 2013 Wales Honorary Senior Fellow - Illawarra health and medical Research Institute, School of Medicine, University Johnson DW, Atai E, Chan M, Phoon RKS, Scott C, of Wollongong Tussaint N, Turner GI, Usherwood T, and Wiggins, K. KHA- CARI guideline: Early chronic kidney disease: detection, Rachel Pons, BNutDietet prevention and management. Nephrology 18 (2013) Lauren Reece, BNutDietet 340–350.

Research Projects in Progress Other Published Material

Does a dietitian-led nutrition care pathway improve Harris, D, Rangan, G, Kairaitis, L and Elder, G. Pocket outcomes in patients with liver cirrhosis attending the Liver Guide to Basic Clinical Dialysis 2 edition. Authors: Michelle Clinic at St George Hospital? Ryan, Maria Chan and Murielle Ryan. Chapter 2 Nutrition. Principal investigators: Rachel Pons, Lauren Reece, Janet Publisher, McGraw-Hill Australia PTY LTD. 2012. Bell, Amany Zekry. Workforce recommendations for renal dietitians in Nutritional Factors and Clinical Outcomes of Patients with Australia and New Zealand, produced by the Australian End Stage Kidney Disease. Implications for practice from and New Zealand renal dietitians workforce planning researching the practice framework. group. Dietitian Association of Australia, 2012.

Principal investigators: Maria Chan, Prof. John Kelly Presentations at Scientific Meetings and (UNSW), Prof. Marijka Batterham (UOW), Prof. Linda Conferences Tapsell (UOW). 2012 – International Original Peer-Reviewed Publications Chan M, Kelly J, Batterham M and Tapsell L. Nutritional 2012 characteristics and dietary intake of patients attending the pre-dialysis assessment clinic. Proceedings of the 16th Chan M, Kelly J, Batterham M and Tapsell L. Malnutrition International Congress of Nutrition and Metabolism in (Subjective Global Assessment) Scores and Serum Albumin Renal Disease (ICNMRD), June, 2012 (Honolulu, Hawaii). Levels, but not Body Mass Index Values, at Initiation of (Poster). Dialysis are Independent Predictors of Mortality: A 10-Year Clinical Cohort Study. J Ren Nutr 2012; 22(6): 547–557. Chan M, Kelly J, Batterham M and Tapsell L. Self-reported appetite and intake adequacy in patients with non-dialysis Manning F, Harris K, Duncan R, Walton K, Bracks J, Larby chronic kidney disease. Proceedings of the 16th ICNMRD, L, Vari L, Jukkola K, Bell J, Chan M and Batterham M. June, 2012 (Honolulu, Hawaii). Additional feeding assistance improves the energy and protein intakes of hospitalised elderly patients. A health 2013 - International services evaluation. Appetite 2012, 59(2): 471–477. Patwardhan A, Ryan C and Chan M, (workshop leader),

144 Evidence and Practice Guidelines for the Nutritional Janet Bell Management of Adult Kidney Transplant Recipients. 16th Home Enteral Nutrition Co Chair, Agency for Clinical International Congress of Dietetics (Sydney, Australia). Information. Chan M, Patwardhan A, Lambert K, and Crosby C (workshop leader). Evidence and practice guidelines for the nutritional management of people with chronic kidney disease stages 1–3, early to moderate renal insufficiency (GFR 30–90 mL/min/1.73m2). 16th International Congress of Dietetics (Sydney, Australia).

2013 National

Chan, M. Invited lecture; Nutritional factors affecting clinical outcomes of patients with End stage kidney disease. The Australasian Society for Parenteral and Enteral Nutrition (AuSPEN), Annual Scientific Meeting, Sydney, November, 2013.

Chan M, Kelly J, Batterham M and Tapsell L. Nutritional characteristics and dietary intake of patients at enrolment to the pre-dialysis assessment clinic. Dietitians Association of Australia 30th National Conference, May. Canberra, Australia.

Chan M, Kelly J, Batterham M and Tapsell L. Self-reported appetite and adequacy of energy and protein intakes in patients with non-dialysis chronic kidney disease, Dietitians Association of Australia 30th National Conference, May, Canberra, Australia.

Chan M, Kelly J, Batterham M and Tapsell L.Nutritional status is associated with the future treatment choice - renal replacement therapy vs. conservative care in end stage kidney disease patients attending the multidisciplinary pre-dialysis assessment clinic. Australian and New Zealand Society of Nephrology, Brisbane, Australia.

Community Engagement

Maria Chan

Allied Health Representative, Ministry of Health - Renal Plan Reference Group for 2013 to 2022

Allied Health Representative, ACI, Renal Service Network (RSN) Executive Committee, NSW Health

Allied Health Representative, ACI, Renal Service Network (RSN) Transplant sub-committee, NSW Health.

145 > Occupational Therapy, St George Hospital

Head of Department

Sharryn Fitzgerald B.App.Sc (OT)

Research Staff

Ms Pamela Maryse Arndt BAppSc(OT) Mr Glenn Paull RN BN(Honours) Master of Nursing Presentations at Scientific Meetings and Conferences

2013 National

Arndt PM, Paull G.

Living Well with Heart Failure: a role for Occupational Therapy in the management of chronic heart failure.

Australian Cardiovascular Health & Rehabilitation Association Annual Scientific Meeting – Melbourne.

Oral presentation selected for the clinical prize session

146 > Physiotherapy , St George Hospital

Head of Department Presentations at Scientific Meetings and Conferences Jason Phillips, B.App.Sc (Physio) SGSHHS Sector head Physiotherapy 2012 - International Susan Sellars, B.App.Sc (Physio) St George Hospital Physiotherapy Unit Head Hayes, W. A prospective Randomised Controlled Trial Comparing pelvic Floor Treatments by a Pelvic Senior Physiotherapists Floor Physiotherapist Versus Extracorporeal magnetic Stimulation. The RCT compared treatments for Wendy Hayes, APA, M. Continence and Women’s Health, women with Stress Urinary Incontinence. International PGCert Pelvic Floor Rehab, Dip Physiotherapy, Women’s Urogynaecology Association Conference, Brisbane, Health Senior Physiotherapist, Conjoint Lecturer UNSW. November. (Podium Presentation and Poster). Wendy Chaseling, APA M.Hlth.Sc (cardiopul. physio, USyd), M.Ed (UNSW) , B.App.Sc (physio., USyd) ICU Senior Community Engagement Physiotherapist, Cardiorespiratory Physiotherapist. Wendy Chaseling

Research Grants Chair of Working Party for Agency for Clinical Innovation– Intensive Care Co-Ordination and Monitoring Unit Best NHMRC TEAM study: Carol Hodgson, Chief Investigator Practice Guideline for Suctioning. Systematic Review (The Alfred Hospital, Melbourne), Sue Berney, Rinaldo conducted. Clinical Practice Guidelines for all clinical Bellomo, Linda Denehy, Megan Harrold, Lisa Higgins, Jeff disciplines (including Medical, Physiotherapy and Nursing) Presnell, Dr Manoj Saxena (St George Hospital), Elizabeth written and published: http://intensivecare.hsnet.nsw.gov. Skinner, Steve Webb, Paul Young, Heidi Buhr Site au/icwiki/index.php/Suction Investigator: Wendy Chaseling, Physiotherapist St George Hospital

TEAM (Trial of Early Activity and Mobility in Intensive Care) $45,000: 2011-2013 Research Projects in Progress

TEAM study: Observational study to review the current practice of patient mobility in 25 Intensive Care Units across Australia and New Zealand, to determine barriers to mobility and what type of activities are undertaken by ICU patients.

Principal investigators (as above) Site Investigator: Wendy Chaseling, Physiotherapist St George Hospital Other Published Material

Harris, D, Rangan, G, Kairaitis, L and Elder, G. Pocket Guide to Basic Clinical Dialysis 2 edition. Authors: Michelle Ryan, Maria Chan and Murielle Ryan. Chapter 2 Nutrition. Publisher, McGraw-Hill Australia PTY LTD. 2012.

Workforce recommendations for renal dietitians in Australia and New Zealand, produced by the Australian and New Zealand renal dietitians workforce planning group. Dietitian Association of Australia, 2012. 147 > Speech Pathology

Head of Department Maclean, J – Co-Author - ACI - Care of adult patients in acute care facilities with a tracheostomy – Clinical Practice Tracy Kelly, B.App.Sc (Speech Pathology) Guideline 2013. Senior Speech Pathologists Maclean, J – Co-Author - Speech Pathology Australia - Julia Maclean, PhD; M.Sc. (Medicine); B.App.Sc (Speech Clinical Guideline – Laryngectomy Management 2012. Pathology) Presentations at Scientific Meetings and Wendy Relf, M.HealthSc. (Communications), B.App.Sc Conferences (Speech Pathology), BA (Linguistics/Psych) 2012 - International Research Grants Maclean, J.C., Szczesniak M, Zhang, T, Graham, P, Cook IJ. NHMRC Predicting dysphagia-related complications and - Dysphagia Research Society, Toronto, USA, March 2012. improving outcomes in patients treated with head and Dysphagia is a prevalent and under-recognized neck radiotherapy. Prof Ian Cook, Dr Michal Szczesniak, Dr complication of head and neck radiotherapy. Julia Maclean, A/Prof Peter Graham, Dr Taher Omari. Maclean J, Szczesniak M, Paramsothy S, Zhang T, Graham, $301,624 (2012-2014). P, Cook IJ. Australian and New Zealand Head and Neck Research Projects in Progress Cancer Society, Brisbane, October, 2012, Oesophageal dysmotility in laryngectomy patients: An unrecognized Predicting dysphagia-related complications and improving association. outcomes in patients treated with head and neck . radiotherapy. Prof Ian Cook, Dr Michal Szczesniak, Dr Julia 2012 - National Maclean, A/Prof Peter Graham, Dr Taher Omari. (Women’s Maclean J, Szczesniak M, Paramsothy S, Zhang T, Graham, and Children’s Health, Adelaide). P, Cook IJ. Australian and New Zealand Head and Neck Prospective, randomized controlled trial of cricopharyngeal Cancer Society, Brisbane, October, 2012, Oesophageal dilatation in post-laryngectomy dysphagia. Dr Peter Wu, dysmotility in laryngectomy patients: An unrecognized Prof Ian Cook, Dr Michal Szczesniak, Dr Julia Maclean. association.

Influence of Altered Pharyngo-esophageal Biomechanical Maclean, J.C., Szczesniak M, Graham, P, Cook IJ. Parameters on Swallowing and Speech Function in Australian and New Zealand Head and Neck Cancer Laryngectomees. Ms Teng Zhang Professor Ian Cook, Dr Society, Brisbane, October, 2012, Long-term dysphagia Michal Szczesniak, A/Prof Paul Bertrand (UNSW), Dr Julia following Radiotherapy. Maclean. Maclean, J.C., Australian and New Zealand Head and Original Peer-Reviewed Publications Neck Cancer Society, Brisbane, October, 2012, invited panellist IFHNOS Session 3: Multidisciplinary Therapy. Krishnan, S. and Maclean J (2013). Practice of 2013 - International laryngectomy rehabilitation interventions: a perspective from Australia. Current Opinion in Otolaryngology and Maclean, J.C., Ward EC., Findlay M, Rees G Head and Neck Surgery 21(3):224-229. Dysphagia Research Society, Seattle, USA, March 2013. Other Published Material Dysphagia and nutritional management in Australian and New Zealand head and neck cancer centres. Perry, A. and Maclean, J. (2012) Rehabilitation after Treatment for Recurrent Head and Neck Cancer. 2013 - National In H. Mehanna and K. Ang (Eds), Head and Neck Cancer Recurrence: Evidence-based, Multidisciplinary Maclean, J.C., Szczesniak M, Graham, P, Cook IJ. Management (pp. 253-259). Germany: Thieme. Australian and New Zealand Head and Neck Cancer

148 Society, Melbourne, September, 2013, Cricopharyngeal dysfunction – assessment and treatment. Community Engagement

Julia Maclean Executive member – Australian and New Zealand Head and Neck Cancer Research Foundation Executive Australian and New Zealand Head and Neck Cancer Society.

Wendy Relf Representative - ACI/Stroke Services NSW

149

Dr Margot Phillips ERRATUM BABSc (Med) MBBS FRANZCP In the 2010-11 Research Report, the following report from Vocational registrars, advanced trainees Mental Health was inadvertently cut during the printing Dr Roslyn Lai (MBBS, MD) - 2011 process. The full version of the report appears below. Senior research staff 1. Department title – Mental Health Unit, Mental Dr Angelo Alonzo (BA, BSc (Hons), Ph.D) Health Academic Unit / School of Psychiatry Dr Donel Martin (MClinNeuroPsych; PhD), BA (Hons); 2. Departmental Staff* MClinNeuroPsy

Head of Department Research assistants Dr Kevin Clarke Natalie Katalinic (BA (Hons) MBBS(Hons), MHA, Grad Dip FBS, FRANZCP Research students

Conjoint Lecturer UNSW Michael Player (BPsych (Hons), Ph.D) Professor Colleen Loo (MB.BS. (Hons), FRANZCP, Varsha Sivalingham (ILP) MD.; Rose Liu (ILP) Professor – School of Psychiatry UNSW; Natalie Johnston (BSc, MB BS)

Research Psychiatrist – Black Dog Institute) Nursing & Allied Health research staff

Dr Matthew Boulton Dr Grace Chan (BA Nursing), PhD) BMBS BSc FRANZCP Psychiatrist – PECC 3. Research Grants# Conjoint Associate Lecturer UNSW Category I - Nationally Competitive Grants Dr Anne Camac NHMRC Project Grant ID 510142 - A Sham-controlled MBBS, FRANZCP Study of Transcranial Direct Current Stimulation (tDCS) as a Conjoint Lecturer UNSW Treatment for Depression. Dr Mesut Cetiner Professor Colleen Loo MBBS Bsc (Med) (Hons) FRANZCP $400,500 (2008-2010) Certificate POA & Conjoint Lecturer UNSW NHMRC Project Grant ID 568678 - A controlled study of Dr Denise Cupina bilateral electroconvulsive therapy MD, FRANZCP Professor Colleen Loo, Professor Isaac Schweitzer Conjoint Senior Lecturer UNSW $421,268 (2009-2011)

Dr Spencer Duke NHMRC Project Grant ID 1004152 – Role of neurogenesis BMedSci BM BS MRCPsych FRANZCP in clinical recovery from depression during ECT: Conjoint Senior Lecturer UNSW Application of a novel in vivo magnetic resonance spectroscopy technology. Dr Andrew Gerard Dr Michael Valenzuela, Professor Colleen Loo, Dr Jesus MBBS FRANZCP Pujol, Professor Petar Djuric, Dr Dennis Velakoulis, Associate Professor Murat Yucel, Professor Mike Dragunow Dr Peter Jones $505,312 (2011-2013) MBChB MRCPsych FRANZCP NARSAD young Investigator Award – Remediation of Dr Andrew Kaill cognitive dysfunction in euthymic bipolar disorder patients BMED FRANZCP TA using transcranial direct current stimulation (tDCS) Dr Yana Kay Dr Donel Martin MBBS, BA, PHD FRANZCP $60,000 USD (2011-2012) Conjoint Lecturer UNSW Category II - Other competitive grants Dr Andrew Pethebridge MBBS, MM (Ven Sci), MM, FRANZCP, FAChAM Category III – Industry and other research funding: Conjoint Senior Lecturer UNSW UNSW Gold Star Award. Outcomes of Standard and

151 Ultrabrief Pulsewidth ECT. Genetic Factors, Biomarkers and Outcomes of Brain Professor Colleen Loo Stimulation $40000 (2010) Professor Colleen Loo

UNSW Gold Star Award. A comparative study of two forms A study of transcranial electrical stimulation of ECT: standard and ultrabrief pulsewidth. Professor Colleen Loo, Prof Phil Mitchell, Prof Perminder Professor Colleen Loo Sachdev, Dr Donel Martin, Dr Angelo Alonzo $40000 (2011) A study of ketamine as an antidepressant UNSW Gold Star Award. A controlled trial of ketamine as Professor Colleen Loo, Dr John Leyden, Dr Simon Harper, an adjunctive agent in ECT. Dr Jenny McGoldrick, Dr Jarrett Johnston, Dr Harry Wark, Professor Colleen Loo Natalie Katalinic, Dr Grace Chan $40000 (2011) Open Pilot Trial of Temporal Lobe Transcranial Direct UNSW Early Career Faculty Research Grant – The effect of Current Stimulation (tDCS) for Depression timing of transcranial direct current stimulation (tDCS) for Professor Colleen Loo, Dr Angelo Alonzo, Dr Donel Martin enhancing learning during cognitive training. Investigating Direct current Stimulation as a Treatment for Dr Donel Martin Depression: A Controlled Clinical Trial $17,000 (2011) Professor Colleen Loo, Professor Philip Mitchell, Professor 4. Research Projects in Progress Perminder Sachdev, Dr Angelo Alonzo, Dr Donel Martin

A controlled study of ultrabrief pulsewidth ECT Enhancing cognitive training using transcranial direct Professor Colleen Loo, Professor Isaac Schweitzer current stimulation (tDCS): a randomised controlled trial. Dr Donel Martin, Professor Colleen Loo, Dr Melissa Green An effectiveness trial assessing the efficacy and cognitive side effects of BT, BF and RUL ECT The Effect of Timing of Transcranial Direct Current Professor Colleen Loo, Dr Bill Lyndon Stimulation (tDCS) for Enhancing Learning During Cognitive Training A double-blind, randomised, placebo-controlled study of Dr Donel Martin, Professor Colleen Loo, Dr Melissa Green, adjunctive ketamine anaesthesia in ECT (electroconvulsive Dr Angelo Alonzo therapy) Professor Colleen Loo, Associate Professor Ross Remediation of Cognitive Dysfunction in Euthymic Bipolar MacPherson, Dr Ron Woodey, Dr Bill Lyndon Disorder Patients Using Transcranial Direct Current Stimulation (tDCS): A pilot study Validation of a new in vivo MRI approach for measurement Dr Donel Martin, Professor Colleen Loo, Dr Melissa Green, of hippocampal neurogenesis in humans Professor Philip Mitchell, Dr Angelo Alonzo Dr Michael Valenzuela, Professor Colleen Loo Neuroplasticity induced by transcranial direct current Genetic factors, biomarkers, and outcomes in ECT stimulation treatment. Professor Colleen Loo Professor Colleen Loo, Dr Janet Taylor, Michael Player

A sham-controlled study of transcranial direct current 5. Original Peer-Reviewed Publications stimulation (tDCS) as a treatment for depression Professor Colleen Loo, Professor Philip Mitchell, Professor Loo C, Sachdev P, Martin D, Pigot M, Alonzo A, Malhi Perminder Sachdev, Melissa Pigot G, Lagopoulos J, & Mitchell P. A double-blind, sham- controlled trial of transcranial direct current stimulation Open pilot trial of transcranial direct current stimulation for the treatment of depression. International Journal of (tDCS) using alternative electrode montages. Neuropsychopharmacology 2010; 13:61-69. Professor Colleen Loo, Prof Phil Mitchell, Prof Perminder Sachev, Dr Donel Martin, Dr Angelo Alonzo O’Reardon JP, Solvason HB, Janicak PG, Sampson S, Isenberg KE, Nahas Z, McDonald WM, Avery D, Fitzgerald Investigating methods to enhance the excitatory effects of PB, Loo C, Demitrack MA, George MS, Sackeim HA. Reply transcranial direct current stimulation (tDCS). Regarding “Efficacy and Safety of Transcranial Magnetic Professor Colleen Loo, Prof Phil Mitchell, Prof Perminder Stimulation in the Acute Treatment of Major Depression: Sachev, Dr Donel Martin, Dr Angelo Alonzo A Multisite Randomized Controlled Trial”. Biological Comparison of measures of plasticity Psychiatry 2010; 67:e15-e17. Professor Colleen Loo, A/Prof Janet Taylor, Prof Perminder Arul-Anandam A, Loo CK & Mitchell P. Induction of Sachev, Michael Player hypomanic episode with transcranial direct current 152 stimulation. Journal of ECT 2010; 26:68-69. Disorders, 2011; 132: 1-13.

Loo C, Sainsbury K, Mitchell P, Hadzi-Pavlovic D, Sachdev Loo C, Martin D, Alonzo A, Gandevia S, Mitchell P, P. A Sham-Controlled Trial of Left and Right Temporal Sachdev P. Avoiding Skin Burns with Transcranial rTMS for the Treatment of Auditory Hallucinations. Direct Current Stimulation: Preliminary Considerations. Psychological Medicine 2010; 40(4):541-546. International Journal of Neuropsychopharmacology, 2011;14(3):425-6. Loo C, Kaill A, Paton P, Simpson B. The Difficult-to- Treat Electroconvulsive Therapy Patient - Strategies for Loo C, Mahon M, Katalinic N, Lyndon B, Hadzi-Pavlovic Augmenting Outcomes. Journal of Affective Disorders D. Predictors of Response to Ultrabrief Right Unilateral 2010; 124(3):219-227. Electroconvulsive Therapy. Journal of Affective Disorders 2011; 130: 192-197. Matheson S, Green M, Loo C & Carr V. Quality assessment and comparison of evidence for electroconvulsive therapy Galvez V, Alonzo A, Martin D, Mitchell P, Sachdev P, and repetitive transcranial magnetic stimulation for Loo C. Hypomania induction in a bipolar II patient with schizophrenia: a systematic meta-review. Schizophrenia transcranial Direct Current Stimulation (tDCS). Journal of Research 2010; 118(1-3): 201-210). ECT 2011; 27(3):256-258.

MacPherson R, Lawford J, Simpson B, Mahon M, Scott D Stewart P, Loo C, MacPherson R, Hadzi-Pavlovic D. and Loo CK. Low dose lignocaine added to propofol does The Effect of Electrode Placement and Pulse Width on not attenuate the response to electroconvulsive Therapy. Asystole and Bradycardia during the Electroconvulsive Journal of Affective Disorders, 2010; 126(1-2): 330-3. Therapy Stimulus. International Journal of Neuropsychopharmacology 2011; 14(5):585-94. Loo CK, Simpson B, MacPherson R. Augmentation Strategies in Electroconvulsive Therapy. Journal of ECT Rushby J, Vercammen A, Loo C, Short B, Weickert C, 2010; 26: 202-207. Weickert T. Frontal versus parietal contributions to probabilistic association learning. Cerebral Cortex 2011; Matheson S, Green M, Loo C & Carr V. A change in 21(8):1879-1888. the conclusions of a recent systematic meta-review: repetitive transcranial magnetic stimulation is effective for Mitchell P, Frankland A, Hadzi-Pavlovic D, Roberts G, the negative symptoms of schizophrenia. Schizophrenia Corry J, Wright A, Loo C, Breakspear M. A comparison Research, 2010; 122 (1-3): 276-277. of depressive episodes in bipolar disorder and major depressive disorder within bipolar disorder pedigrees. Haskett R & Loo C. Role of Adjunctive Psychotropic British J Psychiatry 2011; 199: 303-309. Doi 10.1192/bjp. Medications during ECT in the Treatment of Depression, bp.110.088823 Mania and Schizophrenia. J ECT 2010; 26:196-201. Alonzo A, Brassil J, Taylor J, Martin D, Loo C. Daily Loo C, Kayess R, Alonzo A, Rendina N, Trollor J. Mental transcranial Direct Current Stimulation (tDCS) leads to Health Legislation & Psychiatric Treatments in NSW: greater increases in cortical excitability than second Electroconvulsive Therapy and Deep Brain Stimulation. daily tDCS. Brain Stimulation 2011, doi:10.1016/j. Australasian Psychiatry, 2010; 18(5): 417-425. brs.2011.04.006.

Janicak, P, Nahas Z, Lisanby S, Solvason HB, Sampson S, Martin D, Alonzo A, Mitchell P, Sachdev P, Galvez V, Loo C. McDonald W, Marangell L, Rosenquist P, McCall V, Kimball Fronto-extracephalic transcranial direct current stimulation J, O’Reardon J, Loo C, Husain M, Krystal A, Gilmer W, as a treatment for major depression: An open-label pilot Dowd S, Demitrack M, Schatzberg A.4Durability of Clinical study. Journal of Affective Disorders 2011; 134(1-3):459- Benefit With Transcranial Magnetic Stimulation (TMS) in 463. the Treatment of Pharmacoresistant Major Depression: Assessment of Relapse During a Six-Month, Multisite, Vercammen A, Rushby J, Loo C, Short B, Weickert C, Open-Label Study. Brain Stimulation, 2010; 3(4): 187-199. Weickert T. Transcranial Direct Current Stimulation (tDCS) influences probabilistic association learning in people with Ehnvall A, Mitchell P, Hadzi-Pavlovic D, Loo C, Breakspear schizophrenia. Schizophrenia Research 2011; 131(1-3):198- M, Wright A, Roberts G, Frankland A, Corry J. Pain 205. and rejection sensitivity in bipolar depression. Bipolar Disorders, 2011; 13(1): 59-66. Bai S, Loo C, Dokos S. A computational model of direct brain excitation induced by electroconvulsive Loo C, Katalinic N, Mitchell P, Greenberg B. Physical therapy: comparison among three conventional Treatments for Bipolar Disorder: A Review of electrode placements. Brain Stimulation. doi:10.1016/j. Electroconvulsive therapy, Stereotactic Surgery and brs.2011.07.004 other Brain Stimulation Techniques. Journal of Affective 153 6. Other published material (Books, book ECT”. NSW Health ECT conference, March 25-26, 2010. chapters, reviews,) Sydney

Walter G, Rey J, Ghaziudding N, Loo C. Electroconvulsive Invited Lecture “Principles of Brain Stimulation”. NSW Therapy, Transcranial Magnetic Stimulation and Vagus RANZCP Advanced Trainees Program. Sydney, 24 June, Nerve Stimulation (chapter). In: Martin A, Scahill L, 2010. Kratcochvil C (Editors). Pediatric Psychopharmacology: Invited Lecturer, NSW Institute of Psychiatry 3rd Yr Principles and Practice, Second Edition (pp. 363-373). New Trainees, ECT and Brain Stimulation. Sydney 22 July, 2010. York: Oxford University Press, 2010. Invited main speaker, Ramsay Healthcare Continuing Loo C, Greenberg B, Mitchell P. Non-pharmacotherapeutic Education Workshop on “ECT and TMS”, Adelaide Clinic, Somatic Treatments for Bipolar Disorder (ECT, DBS, SA, 9 Sept, 2010 rTMS) (chapter). In: Manji H & Zarate C (eds) Behavioral Neurobiology of Bipolar Disorder and Its Treatment (pp. Keynote Speaker, Queensland Neuropsychiatry Interest 285-302). Springer Verlag, 2011. Group 7th Annual ECT Forum, Brisbane. “ECT – Stimulus Parameters”. Brisbane, 16 Oct, 2010. Mitchell P, Hadzi-Pavlovic D, Loo C. Course and Outcome of Bipolar Disorder (chapter). In: Manji H & Zarate C (eds) Presentation “tDCS in depression” and Panel Discussant Behavioral Neurobiology of Bipolar Disorder and Its “Physical Treatments of Depression”, Depression Treatment (pp. 1-18). Springer Verlag, 2011. Masterclass, hosted by Servier. Sydney 7 Nov, 2010.

7. Presentations at Scientific Meetings/ Plenary Speaker “Synergistic antidepressant effects with Conferences ketamine and ECT” Australasian Society for Psychiatric Research, 6-8 Dec, Sydney, 2010 Loo C, Sainsbury K, Mitchell P, Hadzi-Pavlovic D, Sachdev P. A Sham-controlled Trial of Left and Right Temporal rTMS Chair, Early Career Researchers symposium. Australasian for the Treatment of Auditory Hallucinations. Australian Society for Psychiatric Research, 6-8 Dec, Sydney, 2010 and NZ Journal of Psychiatry, 2010; 44 (1): A15-16. Invited speaker, UNSW Brain Sciences Symposium ‘Brain Weickert T, Rushby J, Vercammen A, Weickert C, Loo Stimulation”. Topic: Brain stimulation - a tool for treating C. Effects of Transcranial Direct Current Stimulation psychiatric disorders”, Sydney, 15 March, 2011 on Probabilistic Feedback Learning in People with Invited Speaker, First National Symposium on Translational Schizophrenia. Australian and NZ Journal of Psychiatry, Psychiatry. Topic: “ECT, TMS and DCS: Established and 2010; 44 (1): A16. Emerging Treatments”. Canberra 4-5 April, 2011 Rushby JA, Loo C, Weickert CS, Weickert TW. Effects of Guest Speaker, NSW Health Adult Acute Inpatient transcranial direct current stimulation on probabilistic Benchmarking Forum. Topic: “ECT”. Sydney, 3 May, 2011. category learning in patients with schizophrenia. Schizophr Res, 2010, 117 (Nos 2-3):177. Westmead Hospital Psychiatry Grand Rounds. “Recent Advances in Treatments for Depresssion”. 7 July, 2011 Mitchell, PB, Frankland, A, Hadzi-Pavlovic, D, Roberts, G, Wright, A, Loo, CK, Malhi & Breakspear, MJ 2010, A Psychiatry Grand Rounds, St George Hospital. New comparison of the phenomenology and illness course of Treatments in Depression – Ketamine. 4 August, 2011. major depressive episodes in major depressive disorder and bipolar I and bipolar II disorders, Bipolar Disorders, Psychiatry Grand Rounds, The Sutherland Hospital. New 2010 Vol. 12 (Suppl. 1) page 38 Treatments in depression. 25 August, 2011.

Mitchell P, Frankland A, Hadzi-Pavlovic D, Roberts G, Invited symposium speaker, Australian Society of Wright A, Loo C, Breakspear M. On the nature of major Anaesthetists National Scientific Congress, Sydney, 8 Sept depressive disorder (unipolar depression) in bipolar 2011. Strategies for Optimising ECT. disorder pedigrees. Int J Neuropsychopharm, 2010; 13: St John of God Burwood Grand Rounds. Electroconvulsive 130-130, Suppl. 1 Therapy. 2 Sept, 2011 Weickert T, Gendy R, Chan M, Loo C, Mitchell PB, Australiasian Society for Bipolar Disorders Conference. Weickert CS. Probabilistic association learning impairment ECT workshop chair & speaker: “Optimising ECT: The predicts degree of schizotypal personality traits. importance of stimulus parameters” . Sydney Oct 20-22, Schizophrenia Bulletin, 2011, 37: 233, Suppl. 1. 2011 Invited speaker, “Electrode placement and dosing in Australiasian Society for Bipolar Disorders Conference. 154 Brain stimulation symposium chair and speaker “Novel Brain stimulation – what is the therapeutic potential?” Sydney Oct 20-22, 2011

Queensland Mental Health symposium: An Update on ECT. Invited speaker “New Brain Stimulation Treatment and ECT”. Brisbane Oct 29, 2011

NSW Mental Health Advocacy Service Training Day. “Electroconvulsive Therapy and NSW Health Guidelines”. 15 November, 2011. Sydney.

International

Bai S, Loo C, Dokos S. A Computational Model of Direct Brain Stimulation by Electroconvulsive Therapy. Conf Proc IEEE Eng Med Biol Soc. 2010; 1:2069-72.

Invited workshop presentation/ Meeting Faculty, International Society for ECT and Neurostimulation. Topic: “Transcranial Direct Current Stimulation for Depression”. Hawaii, 15 May, 2011.

8. Community Engagement

“Old Wives Tale: Electroshock treatment is harmful”. Women’s Day, 5 April, 2010

Southern Courier – article on tDCS. June 2010.

ECT research quoted in UK paper, Daily Mail, “How short shocks could transform depression.: June 15, 2010.

“NSW Restrictions on ECT and DBS “not justifiable” Psychiatry Update Newsletter, 30 Sept, 2010. [Australasian Psychiatry 2010; 18: 417-425 quoted]

“Rise and Shine” – interview on ECT. Channel Nine, 2 May, 2010.

Channel 10 News – interview on tDCS, 9 June, 2010.

Interview for radio 2SER on use of ECT, 25.5.2010.

Interview for ABC Radio National, PM program, 8 June, 2010, on tDCS.

Interview for ABC Radio National, Mornings with Deborah Cameron, on tDCS trial in depression. 6 April, 2011

Interview for ABC Radio Canberra, on tDCS trial in depression. 6 April, 2011

Interview for ABC Radio Central West, on tDCS trial in depression. 6 April, 2011

Medical Observer – interview re ECT 8.2.2011

Sun Herald, interviewed for article on ECT, 26 June, 2011

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