RESEARCH >REPORT St George and Sutherland Hospitals 2012 » 2013 > INTRODUCTIONS Professor John Edmonds Conjoint Professor, UNSW Chair of the St George and Sutherland Medical Research Foundation The Research Report of the St George and Sutherland Hospitals, currently published every second year, is an important record of our clinical and research staff and some traditional indicators by which institutions’ research status is judged: projects undertaken, grants awarded, publications and presentations. There are encouraging pointers, great and small, that government and society are increasingly recognising the importance of medical research: McKeon’s Strategic Review of Health and Medical Research; a federal commitment to a 20 billion dollar medical research fund; the choice of Suzanne Corey (former Director of WEHI) as the 2014 Boyer Lecturer; even a recent Q & A session devoted to Science & Australia. As society looks to its great academic medical centres for research-driven guidance, it becomes ever more important that St George and Sutherland Hospitals match the excellence of their clinical service and teaching with a comparable level of eminence in research endeavour and success. The St George and Sutherland Medical Research Foundation is committed to helping the hospitals’ academics in that project. The Research Reports provide a useful audit of our joint progress. Professor Peter Gonski Head, Sutherland Teaching Unit St George Clinical School Although Sutherland Hospital is well known as a provider of major clinical service to the South Eastern Sydney Local Health District, it also provides a major teaching resource to medical, nursing and allied health students. Research is now becoming important in its activities. On behalf of Sutherland, I am grateful that the St George and Sutherland Medical Research Foundation has included us in their activities and also providing research funds. With the close relationships between the hospital, community, Universities and Foundation, which have already been secured, I can only see the research interest increase in the future. I do think that our significant clinical load allows us to be leaders in clinical research and assure that our research will directly influence patient care and lives. It is wonderful to have our research celebrated in this report. Professor Ritin Fernandez Professor of Nursing Research and Innovation is vital to the provision of quality healthcare for our patients. At St George Hospitals clinician and scientists undertake the full spectrum of basic biomedical, clinical and health services research. There has been a remarkable progress in research outputs and outcomes at St George Hospital and this report high lights the unique and influential research that is being conducted by our world class researchers. The report also demonstrates the commitment of researchers and scientists not only towards evidence synthesis but also in translating and implementing the evidence in clinical practice. I would like to acknowledge the role and contribution of the broader hospital community, our patients, the many volunteers, our collaborators and supporters, particularly the St George and Sutherland Medical Research Foundation without whom research here would not be possible. The research achievements are very encouraging, but more importantly they form the foundation for future research endeavours as well as provide inspiration and motivation as we move forward. Professor Michael Grimm Clinical Associate Dean St George Clinical School, UNSW Research in our hospitals fundamentally supports the excellence in clinical care for which we all strive. If anything, this will become even more important in coming years. This important report demonstrates the extraordinary breadth and impressive depth of research activities undertaken at St George and Sutherland Hospitals, and I hope it serves to announce those achievements loudly and emphatically. The composing of a document such as this always comes as a surprise: surprise at the breadth and volume of research carried out by hospital and university staff and students, from most senior to undergraduate levels. It’s a testament to the enormous amount of hard work that goes into making our hospitals vital and inquiring places, as well as places of healing. I commend this report to all members of our hospital communities. > CONTENTS Medicine And Critical Care 5 Mental Health 109 Cardiology 6 Mental Health Academic Unit, School of Psychiatry 110 Dermatology 8 Emergency – St George Hospital 15 Women’s and Children’s Health 115 Emergency – The Sutherland Hospital 18 Endocrinology 19 Urogynaecology 116 Gastroenterology and Hepatology 22 Women’s Health 119 Infectious Disease, Immunology and 27 Sexual Healh Nursing and Midwifery 127 Intensive Care – St George Hospital 31 Nuclear Medicine 41 Centre for Research in Nursing and Health 128 Renal Medicine 42 Respiratory and Sleep Medicine 47 South Eastern Sydney Laboratory 136 Services Rheumatology 49 Anatomical Pathology 137 Cancer Services 52 Aged and Extended Care 139 Haematology 53 Medical Oncology 61 Aged Care St George Hospital 140 Palliative Care 69 Rehabilitation Medicine 141 Radiation Oncology 79 Southcare The Sutherland Hospital 142 Surgery, Perioperative And Anaesthetic 82 Allied Health 143 Services Nutrition and Dietetics 144 Anaesthesia 83 Occupational Therapy 146 Cardiothoracic Surgery 85 Physiotherapy 147 Liver and Periotonectomy Surgery 90 Speech Pathology 148 Orthopaedic Surgery 96 Trauma 104 Erratum 151 Vascular Surgery 108 MEDICINE AND CRITICAL CARE Cardiology > 6 Renal Medicine > 42 Dermatology > 8 Respiratory Medicine > 47 Emergency – Rheumatology St George Hospital > 15 > 49 Emergency – > Sutherland Hospital 18 Endocrinology > 19 Gastroenterology and > Hepatology 22 Infectious Disease, Immunology and Sexual > 27 Health Intensive Care – > St George Hospital 31 Nuclear Medicine > 41 > Department of Cardiology Head of Department Lead in the clinical MRI (Magnetic Resonance Imaging) environment, Dr Andrew Hopkins. Dr Mark Sader MBBS(Hons) PhD A Multicentre, Randomised, Double blind, Placebo- Senior Medical - Staff Specialists Controlled Study to Evaluate the Safety and Efficiency of Dr David Ramsay study drug in Addition to Standard of Care in subjects with Dr David Rees Acute Coronary Syndrome. Thrombin Receptor Antagonist Dr Andrew Hopkins in Acute Coronary Syndrome, Dr Ananth Prasan. Dr Maurits Binnekamp A Phase 3, Randomised, Double-Blind, Evaluation of the Dr Ananth Prasan Safety and Efficiency of study drug In Subjects with a Dr George Youssef recent ACS, Dr. Ananth Prasan. Dr James Weaver BSc Med MBBS(Hons) PhD Dr Queenie Lo Trial Evaluating CV Outcomes with study drug in patients Dr Victar Hsieh with Type 2 Diabetes, Dr. Maurits Binnekamp. Research Staff A randomized, double-blind, placebo-controlled, event driven trial of quarterly subcutaneous canakinumab in Deborah Vrachas – CNS the prevention of recurrent cardiovascular events among Glenn Paull - CNC stable post-myocardial infarction patients with elevated Research Projects in Progress hsCRP, Dr George Youssef. A bone marrow-derived Stro3 mesenchymal precursor Original Peer-Reviewed Publications cells (MPC) in the treatment of patients with ST-elevation Rayner BS, Figtree GA, Sabaretnam T, Shang P, Mazhar J, myocardial infarction, Dr. Ananth Prasan. Weaver JC, Lay WN, Witting PK, Hunyor SN, Grieve SM, A Double-blind, Randomized, Placebo-controlled, Khachigian LM, Bhindi R. Selective Inhibition of the Master Multicenter Study Assessing the Impact of Additional Regulator Transcription Factor Egr-1 Using Catalytic LDL-Cholesterol Reduction on Major Cardiovascular Oligonucleotides Reduces Myocardial Injury and Improves Events When AMG 145 is Used in Combination With Statin Left Ventricular Systolic Function in a Preclinical Model Therapy In Patients with Clinically Evident Cardiovascular of Myocardial Infarction. Journal of the American Heart Disease, Dr. Ananth Prasan. Association. 2013; 2 (4):e000023. PMID 23902638. Prevention of contrast-induced acute kidney injury In Sorensen R, Paull G, Magaan L, Davis JM (2013). people undergoing angiogram, Dr. Ananth Prasan. Managing between the agendas - implementing health care reform policy in an acute care hospital. Journal of TIGRIS Study data collection 1-3yr post MI patients, Dr Health Organization and Management; 27 (6) 698-713. Mark Sader Presentations at Scientific Meetings and Study to evaluate Cardiovascular Outcomes Following Conferences Treatment with study drug in Addition to Standard of Care in Subjects with Type 2 DM and ACS, Dr. Ananth Prasan. 2012 International Thromectomy VS PCI alone in STEMI patients, Dr James Sorensen R, Paull G, Magaan L, Davis JM. Is poor quality Weaver. of care built into the system? Evidence from a study on communication among teams treating people dying in The Advisa MRI System study is a prospective, randomised hospital wards. 8th International Organisational Behaviour controlled, non-blinded, multi centre worldwide in Healthcare Conference - Patient-centred healthcare investigational study, Dr Andrew Hopkins. teams: achieving collaboration, communication and care. Dublin, Ireland. To confirm safety and effectiveness of the Model 5076 6 2012 National Paull G, Gallagher R, Horvath R, Chen D. Discrimination and high sensitivity cardiac troponin: the relationship between clinical presentation, clinical request and discharge diagnosis. 60th Annual Scientific Meeting of Cardiac Society of Australia and New Zealand, Brisbane. Chandrasekhar