Anti-NEDD4L (Aa 100-200) Polyclonal Antibody (DPABH-17505) This Product Is for Research Use Only and Is Not Intended for Diagnostic Use

Anti-NEDD4L (aa 100-200) polyclonal antibody (DPABH-17505) This product is for research use only and is not intended for diagnostic use.

PRODUCT INFORMATION

Antigen Description E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.

Immunogen Synthetic peptide conjugated to KLH derived from within residues 100 - 200 of Human NEDD4-2.

Isotype IgG

Source/Host Rabbit

Species Reactivity Mouse, Human

Purification Immunogen affinity purified

Conjugate Unconjugated

Applications ICC/IF, WB

Format Liquid

Size 100 μg

Buffer Constituents: 1% BSA, PBS, pH 7.4

Preservative 0.02% Sodium Azide

Storage Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

GENE INFORMATION

Gene Name NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E4 ubiquitin protein ligase [ Homo sapiens ]

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]

Synonyms NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; RSP5; NEDD4-2; NEDD4.2; hNEDD4-2; E3 ubiquitin-protein ligase NEDD4-like; ubiquitin-protein ligase Rsp5;

Entrez Gene ID 23327

Protein Refseq NP_001138436.1

UniProt ID A0A024R2A4

Pathway Adaptive Immune System; Aldosterone-regulated sodium reabsorption; Budding and maturation of HIV virion; Disease

Function ion channel binding; ligase activity; potassium channel inhibitor activity; potassium channel regulator activity

45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected]