Anti-NEDD4L (aa 100-200) polyclonal antibody (DPABH-17505) This product is for research use only and is not intended for diagnostic use. PRODUCT INFORMATION Antigen Description E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2. Immunogen Synthetic peptide conjugated to KLH derived from within residues 100 - 200 of Human NEDD4-2. Isotype IgG Source/Host Rabbit Species Reactivity Mouse, Human Purification Immunogen affinity purified Conjugate Unconjugated Applications ICC/IF, WB Format Liquid Size 100 μg Buffer Constituents: 1% BSA, PBS, pH 7.4 Preservative 0.02% Sodium Azide Storage Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles. GENE INFORMATION Gene Name NEDD4L neural precursor cell expressed, developmentally down-regulated 4-like, E4 ubiquitin protein ligase [ Homo sapiens ] 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 1 © Creative Diagnostics All Rights Reserved Official Symbol NEDD4L Synonyms NEDD4L; neural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase; RSP5; NEDD4-2; NEDD4.2; hNEDD4-2; E3 ubiquitin-protein ligase NEDD4-like; ubiquitin-protein ligase Rsp5; Entrez Gene ID 23327 Protein Refseq NP_001138436.1 UniProt ID A0A024R2A4 Pathway Adaptive Immune System; Aldosterone-regulated sodium reabsorption; Budding and maturation of HIV virion; Disease Function ion channel binding; ligase activity; potassium channel inhibitor activity; potassium channel regulator activity 45-1 Ramsey Road, Shirley, NY 11967, USA Email: [email protected] Tel: 1-631-624-4882 Fax: 1-631-938-8221 2 © Creative Diagnostics All Rights Reserved.