DOCSLIB.ORG

04 14037 Akciger 2014.Indb

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
04 14037 Akciger 2014.Indb KONGRE SEKRETERI Doç.Dr. Ilgaz Doğusoy E-Posta: [email protected] ORGANIZASYON SEKRETERYASI Serenas Uluslararası Turizm Kongre Organizasyon A.Ş. Şerifali Mah. Pakdil Sok. No: 5 Yukarı Dudullu- Ümraniye / İstanbul Tel : 0216 594 58 26 Faks : 0216 594 57 99 E-Posta : [email protected] İÇİNDEKİLER ÖNSÖZ .................................................................................................................................................................................5 EDİTÖRLER KURULU ..............................................................................................................................................................6 KONULAR MAKALE YAZIMINDAKİ TEMEL İLKELER .................................................................................................................................................................................7 Ali Özdülger EDİTÖRLER VE HAKEMLER YAZILARI NASIL DEĞERLENDİRİYOR? ...................................................................................................................................8 Akif Turna SUNUMLARIMIZI ETKİNLEŞTİRMEK .....................................................................................................................................................................................11 Göksel Altınışık MALNUTRİSYON TANIMI, ÖNEMİ VE BESLENME DURUMUNUN DEĞERLENDİRİLMESİ ..........................................................................................13 Derya Hopancı Bıçaklı NÜTRİSYON DESTEĞİNDE TEMEL İLKELER ..........................................................................................................................................................................15 Mehmet Uyar ENTERAL NUTRİSYON VE ERİŞİM YOLLARI .........................................................................................................................................................................17 Mutlu Doğanay PARENTERAL NUTRİSYON VE ERİŞİM YOLLARI .................................................................................................................................................................19 Mutlu Doğanay KEMORADYOTERAPİ UYGULANAN HASTALARDA NÜTRİSYON DESTEĞİ .....................................................................................................................20 Diclehan Kılıç KAŞEKSİ FİZYOPATOLOJİSİ ......................................................................................................................................................................................................21 Diclehan Kılıç SENKRON AKCİĞER KARSİNOMU, OLGU SUNUMU ..........................................................................................................................................................22 Celalettin Kocatürk TÜRKİYE AKCİĞER KANSERİ EPİDEMİYOLOJİSİ .................................................................................................................................................................23 Ezgi Hacıkamiloğlu KÜRESEL YETİŞKİN TÜTÜN ARAŞTIRMASI, 2012 TÜRKİYE SONUÇLARI .....................................................................................................................24 Nazmi Bilir SİGARA İÇMEYENLERDE AKCİĞER KANSERİ .......................................................................................................................................................................27 Pınar Çelik VOLUMETRİK DEĞERLENDİRME ve RADYASYON RİSKİ ...................................................................................................................................................29 Nuri Tasalı AKCİĞER KANSERLİ HASTALARDA PERİOPERATİF NUTRİSYON DESTEĞİ ...................................................................................................................31 Celalettin Kocatürk AKCİĞERİN NÖROENDOKRİN TÜMÖRLERİ ..........................................................................................................................................................................32 Deniz Nart KÜÇÜK HÜCRELİ AKCİĞER KANSERİNDE RADYOTERAPİ UYGULAMALARI .................................................................................................................36 Deniz Yalman AKCİĞER NÖROENDOKRİN TÜMÖRLERİNDE SİSTEMİK TEDAVİ: AKCİĞER NÖROENDOKRİN TÜMÖRLERİ (ANT) .............................................38 Feyyaz Özdemir 3 İKİNCİ SERİ IŞINLAMA: RADYOBİYOLOJİK VE TEKNOLOJİK TEMELİ .............................................................................................................................40 Uğur Selek ADJUVAN TEDAVİ KARARINI VE İLAÇ SEÇİMİNİ ETKİLEYECEK İPUÇLARI VAR MI? ..................................................................................................41 Deniz Yamaç AKCİĞER KARSİNOMLARINDA PATOLOJİ TEDAVİYİ NASIL YÖNLENDİRİR? ...............................................................................................................42 Büge Öz METASTATİK KÜÇÜK HÜCRELİ AKCİĞER KANSERİNDE ZORLUKLAR VE GELECEK: SİSTEMİK TEDAVİDE GELİŞMELER ....................................44 Başak Oyan Uluç ÖSOFAGUS KANSERİNDE 7. REVİZYON, ŞU ANKİ DURUM VE 8. REVİZYONA ETKİLERİ ..........................................................................................46 Atilla Eroğlu ÖZOFAGUSUN SQUAMÖZ HÜCRELİ KANSERİNDE KEMOTERAPİ VEYA DEFİNİTİF KEMORADYOTERAPİ .............................................................47 Sezer Sağlam HANGİ T4 HASTALIKTA CERRAHİ TEDAVİ ............................................................................................................................................................................49 Soner Gürsoy CERRAHİ SONRASI YAŞAM KALİTESİNİ BOZAN DURUMLAR ..........................................................................................................................................52 Ertan Aydın MALİGN MEZOTELYOMA: HİSTOPATOLOJİK ÖZELLİKLER VE SON GELİŞMELER .........................................................................................................53 Serpil Dizbay Sak HİPERTEMİK PLEVRAL KEMOTERAPİ ...................................................................................................................................................................................57 Ahmet Feridun Işık MEZOTELYOMADA SİSTEMİK TEDAVİNİN ROLÜ .................................................................................................................................................................59 P. Fulden Yumuk MEZOTELYOMADA RADYOTERAPİ: KİME, NE ZAMAN? .....................................................................................................................................................61 Cem Önal GÖĞÜS CERRAHİSİNDE ENERJİ CİHAZLARININ KULLANIMI ..........................................................................................................................................64 Akif Turna ROBOTİK CERRAHİ ENDİKASYONLARI .................................................................................................................................................................................66 Şükrü Dilege TRAKEA TÜMÖRLERİ .................................................................................................................................................................................................................68 Adnan Sayar MALİGN PLEVRAL EFFÜZYONLARA YAKLAŞIM ..................................................................................................................................................................70 Hüseyin Yıldırım AKCİĞER KANSERLERİNDE GENETİK ....................................................................................................................................................................................71 İsmail Savaş SEÇİLMİŞ BİLDİRİLER ...............................................................................................................................................................................................................73 SÖZEL BİLDİRİLER .....................................................................................................................................................................................................................79 POSTER BİLDİRİLER ..................................................................................................................................................................................................................87 YAZAR DİZİNİ ............................................................................................................................................................................................................................229 ÖNSÖZ Değerli Meslekdaşlarımız, VI. Ulusal Akciğer Kanseri Kongresi, 8-11 Mayıs 2014 tarihleri arasında, Türk Akciğer Kanseri Derneği (TAKD) ve Türk Göğüs Cerrahisi Derneği (TGCD) tarafından, Antalya’da Cornelia Diamond Hotel’de düzenlenmektedir. TAKD, göğüs hastalıkları, göğüs cerrahisi, radyasyon onkolojisi, tıbbi onkoloji, patoloji, nükleer tıp, radyoloji ve diğer akciğer kanseri/torasik onkoloji ile ilgili uzmanlık dallarını bir araya getirmeyi başarmış bir dernek olarak çalışmalarını sürdürmektedir. Bölge temsilcilikleri ve çalışma gruplarını oluşturarak ülkemiz içindeki etkinliğini arttırmayı planlamıştır. Ayrıca, önümüzdeki dönemde ülkemiz akciğer kanseri sağlık politikalarının oluşturulmasına katkıda bulunmayı amaçlamaktadır. TGCD, göğüs cerrahisi alanında uzmanlık derneği olarak 1998 yılında kurulmuştur. Göğüs
Load more

Recommended publications
  • Understanding Your Pathology Report: Benign Breast Conditions
    cancer.org | 1.800.227.2345 Understanding Your Pathology Report: Benign Breast Conditions When your breast was biopsied, the samples taken were studied under the microscope by a specialized doctor with many years of training called a pathologist. The pathologist sends your doctor a report that gives a diagnosis for each sample taken. Information in this report will be used to help manage your care. The questions and answers that follow are meant to help you understand medical language you might find in the pathology report from a breast biopsy1, such as a needle biopsy or an excision biopsy. In a needle biopsy, a hollow needle is used to remove a sample of an abnormal area. An excision biopsy removes the entire abnormal area, often with some of the surrounding normal tissue. An excision biopsy is much like a type of breast-conserving surgery2 called a lumpectomy. What does it mean if my report uses any of the following terms: adenosis, sclerosing adenosis, apocrine metaplasia, cysts, columnar cell change, columnar cell hyperplasia, collagenous spherulosis, duct ectasia, columnar alteration with prominent apical snouts and secretions (CAPSS), papillomatosis, or fibrocystic changes? All of these are terms that describe benign (non-cancerous) changes that the pathologist might see under the microscope. They do not need to be treated. They are of no concern when found along with cancer. More information about many of these can be found in Non-Cancerous Breast Conditions3. What does it mean if my report says fat necrosis? Fat necrosis is a benign condition that is not linked to cancer risk.
    [Show full text]
  • Intraoral Lipoma: a Case Report
    Hindawi Publishing Corporation Case Reports in Medicine Volume 2014, Article ID 480130, 4 pages http://dx.doi.org/10.1155/2014/480130 Case Report Intraoral Lipoma: A Case Report L. K. Surej Kumar, Nikhil Mathew Kurien, Varun B. Raghavan, P. Varun Menon, and Sherin A. Khalam Department of Oral & Maxillofacial Surgery, PMS College of Dental Science & Research, Golden Hills, Vattappara, Venkode, Thiruvananthapuram 695028, India Correspondence should be addressed to P. Varun Menon; [email protected] Received 13 September 2013; Accepted 19 December 2013; Published 30 January 2014 Academic Editor: David W. Eisele Copyright © 2014 L. K. Surej Kumar et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Lipomas are rare in oral and maxillofacial regions although they are the most common tumours of mesenchymal origin in human body. The etiology remains unclear. Various different theories explain the pathogenesis of this adipose tissue tumour andalso different histological variants of oral lipoma have been given in literature. A case of intraoral lipoma occurring in mental region in a 77-year-old male is reported along with review of the literature. Wide surgical excision was performed and two-year followup showed excellent healing without any recurrence. Lipomas are benign soft tissue neoplasm of mature adipose tissue seen as a common entity in the head and neck region. Intraoral lipomas are a rare entity which may be noticed only during routine dental examinations. Most of them rarely cause pain, resulting in delay to seek treatment.
    [Show full text]
  • WO 2018/035138 Al 22 February 2018 (22.02.2018) W !P O PCT
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2018/035138 Al 22 February 2018 (22.02.2018) W !P O PCT (51) International Patent Classification: SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, A61L 27/36 (2006.01) A01K 67/027 (2006.01) TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. C12N S/00 (2006.01) C12N 5/077 (2010.01) (84) Designated States (unless otherwise indicated, for every C12N 5/071 (2010.01) G01N 33/50 (2006.01) kind of regional protection available): ARIPO (BW, GH, C12N 5/09 (2010.01) GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, (21) International Application Number: UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, PCT/US20 17/046983 TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, LU, LV, (22) International Filing Date: MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM, 15 August 2017 (15.08.2017) TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, (25) Filing Language: English KM, ML, MR, NE, SN, TD, TG). (26) Publication Language: English Published: (30) Priority Data: — with international search report (Art. 21(3)) 62/375,016 15 August 2016 (15.08.2016) US 62/430,015 05 December 2016 (05.12.2016) US (71) Applicants: ORGANOVO, INC.
    [Show full text]
  • WO 2014/080291 A2 30 May 20 14 (30.05.2014) W P O P C T
    (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2014/080291 A2 30 May 20 14 (30.05.2014) W P O P C T (51) International Patent Classification: (81) Designated States (unless otherwise indicated, for every C07D 401/04 (2006.01) kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, (21) International Application Number: BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM, PCT/IB20 13/003 126 DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, (22) International Filing Date: HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KN, KP, KR, 20 November 2013 (20.1 1.2013) KZ, LA, LC, LK, LR, LS, LT, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, (25) Filing Language: English OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, (26) Publication Language: English SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, (30) Priority Data: ZW. 61/729,108 2 1 November 2012 (21. 11.2012) US (84) Designated States (unless otherwise indicated, for every (71) Applicant: RVX THERAPEUTICS INC. [CA/CA]; 202, kind of regional protection available): ARIPO (BW, GH, 279 Midpark Way SE, Calgary, Alberta T2X 1M2 (CA). GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, (72) Inventors: FAIRFAX, David, John; 72 McCormack TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK, Road, Slingerlands, NY 12159 (US).
    [Show full text]
  • Tommunication That This Continuation
    TOMMUNICATIONUS009771363B2 THAT THIS CONTINUATION (12 ) United States Patent (10 ) Patent No. : US 9 ,771 , 363 B2 Ibrahim et al. ( 45) Date of Patent: Sep . 26 , 2017 ( 54 ) HETEROCYCLIC COMPOUNDS AND USES 8 , 119 , 637 B2 2 / 2012 Ibrahim et al . THEREOF 8 , 129 , 404 B2 3 / 2012 Ibrahim et al . 8 ,143 ,271 B2 3 / 2012 Ibrahim et al. 8 , 153 , 641 B2 4 / 2012 Ibrahim et al. ( 71 ) Applicant: Plexxikon Inc. , Berkeley, CA (US ) 8 , 158, 636 B2 4 / 2012 Ibrahim et al . 8 , 198, 273 B2 6 /2012 Ibrahim et al . ( 72 ) Inventors : Prabha N . Ibrahim , Mountain View , 8 , 268, 858 B2 9 / 2012 Wu et al. CA (US ) ; Wayne Spevak , Berkeley , 8 ,367 , 828 B2 2 / 2013 Arnold et al. CA (US ) ; Jiazhong Zhang , Foster City , 8 ,404 , 700 B2 3 /2013 Ibrahim et al. 8 , 415 , 469 B2 4 / 2013 Ibrahim et al. CA (US ) ; Songyuan Shi, Fremont, CA 8 , 461 , 169 B2 6 / 2013 Zhang et al. (US ) ; Ben Powell , Pleasant Hill , CA 8 , 470 , 818 B2 6 / 2013 Ibrahim et al . (US ) ; Yan Ma, Belmont , CA (US ) 8 , 642 , 606 B2 2 / 2014 Ibrahim et al . 8 , 673 , 928 B2 3 / 2014 Ibrahim et al. (73 ) Assignee : Plexxikon Inc ., Berkeley , CA (US ) 8 , 722 , 702 B2 5 /2014 Zhang et al . 8 ,865 , 735 B2 10 / 2014 Diodone et al . 8 ,901 ,118 B2 12 /2014 Zhang et al. ( * ) Notice : Subject to any disclaimer, the term of this 8 , 901, 301 B2 12 / 2014 Ibrahim et al. patent is extended or adjusted under 35 8 , 912, 204 B2B2 12 /2014 Ibrahim et al .
    [Show full text]
  • Pleuropulmonary Blastoma: Case Report
    135 ISSN 2073-9990 East Cent. Afr. J. surg. (Online) Pleuropulmonary Blastoma: Case Report A.Tadesse, MD 1, Philipos Kidane MD 1, Birhanu Nega, MD 1, Jakob Schneider, MD 2, 1Department of Surgery, School of medicine, College of Heath Sciences, Addis Ababa University 2Department of Pathology, School of Medicine, College of Health Sciences, Addis Ababa University Pleuropulmonary blastoma (PPB) is a rare and aggressive tumor that is emerging as a distinct entity of early childhood disease. It is characterized by mesenchymal elements (including undifferentiated blastoma and often cartilaginous, rhabdomyoblastic, or fibroblastic differentiation) and epithelium-lined spaces. The tumor arises in the lung and pleura and is regarded as a pulmonary dysontogenetic or embryonic neoplasm. It is the pulmonary analog of other tumors of childhood including Wilms` tumor, Neuroblastoma, Hepatoblastoma, Pancreatoblastoma and Retinoblastoma. Due to their protean presentation it is often difficult to make a preoperative diagnosis. A high index of suspicion therefore is needed. As a result these are diagnosed late, and these, along with other factors, affect the eventual outcome. We report a case of Pleuropulmonary blastoma diagnosed after the child was operated as a case of massive left hemothorax following blunt trauma . Introduction Pleuropulmonary blastoma (PPB) is a rare and highly aggressive intrathoracic malignancy in childhood and less than 100 cases have been reported in the literature. In 1961, Spencer first used the term and suggested that PPB arose from mesodermal blastoma because of its similarities to nephroblastoma. In the year1988, Manivel et al. described PPB in children as an entity that was distinct from the biphasic epithelial stromal morphology of the classic adult type.
    [Show full text]
  • Case Report Infant Pleuropulmonary Blastoma: Report of a Rare Case and Review of Literature
    Int J Clin Exp Pathol 2015;8(10):13571-13577 www.ijcep.com /ISSN:1936-2625/IJCEP0014587 Case Report Infant pleuropulmonary blastoma: report of a rare case and review of literature Hong Zhang1, Chun-Wei Xu2, Jian-Guo Wei3, Guang-Jun Zhu4, Sheng Xu2, Jin Wang2 Departments of 1Out-Patient, 2Pathology, The General Hospital of Beijing Military Region, Beijing 100700, People’s Republic of China; 3Department of Pathology, The People’s Hospital of Shaoxing Zhejiang, 312000, People’s Republic of China; 4Department of Central Laboratory, 281 Hospital of PLA, Qinhuangdao 066105, Hebei, People’s Republic of China Received August 16, 2015; Accepted September 23, 2015; Epub October 1, 2015; Published October 15, 2015 Abstract: In infants, pleuropulmonary blastoma is a rare but aggressive tumor. The typical histopathological pre- sentation includes the aggregation of malignant primitive small cells, usually observed in sheets. So as to provide proper and timely treatment, the differential diagnosis includes pulmonary blastoma, sarcomatoid mesothelioma, fetal rhabdomyoma, synovial sarcoma, and primitive neuroectodermal tumor. Herein, we will present one male pediatric patient with pleuropulmonary blastoma. The patient was a 4-month-old male infant, who had a prolonged cough and dyspnea for 4 months that was complicated by cyanosis for 3 days. A physical examination revealed a solid mass in the right lung that was sized 9.0 × 6.0 × 4.0 cm and had a grayish-white cross section. The boundary between the mass and lung tissue was clear; the mass already occupied a great portion of the lung. A microscopic examination suggested that the tumor was composed of round or orbicular-ovate primitive fetal cells.
    [Show full text]
  • Malignant Phyllodes Tumor with Extensive Lipomatous Differentiation
    Thomas Jefferson University Jefferson Digital Commons Department of Radiology Faculty Papers Department of Radiology 11-1-2020 Malignant phyllodes tumor with extensive lipomatous differentiation. Jeffrey Landy Thomas Jefferson University Priya Johal Thomas Jefferson University Alexander Sevrukov Thomas Jefferson University Ida Teberian Thomas Jefferson University Jason Shames Thomas Jefferson University Follow this and additional works at: https://jdc.jefferson.edu/radiologyfp Part of the Radiology Commons LetSee next us page know for additional how authors access to this document benefits ouy Recommended Citation Landy, Jeffrey; Johal, Priya; Sevrukov, Alexander; Teberian, Ida; Shames, Jason; Sebastiano, Christopher; and Kaufman, Theresa, "Malignant phyllodes tumor with extensive lipomatous differentiation." (2020). Department of Radiology Faculty Papers. Paper 92. https://jdc.jefferson.edu/radiologyfp/92 This Article is brought to you for free and open access by the Jefferson Digital Commons. The Jefferson Digital Commons is a service of Thomas Jefferson University's Center for Teaching and Learning (CTL). The Commons is a showcase for Jefferson books and journals, peer-reviewed scholarly publications, unique historical collections from the University archives, and teaching tools. The Jefferson Digital Commons allows researchers and interested readers anywhere in the world to learn about and keep up to date with Jefferson scholarship. This article has been accepted for inclusion in Department of Radiology Faculty Papers by an authorized
    [Show full text]
  • Liposarcoma of the Oral Cavity – Case Reports of the Pleomorphic and the Dedifferentiated Variants and a Review of the Literature
    ANTICANCER RESEARCH 26: 4857-4868 (2006) Liposarcoma of the Oral Cavity – Case Reports of the Pleomorphic and the Dedifferentiated Variants and a Review of the Literature FRANCESCA ANGIERO1, ANGELO SIDONI2 and MICHELE STEFANI1 1Institute of Pathological Anatomy, Oral Pathology Section, Milan; 2Institute of Pathological Anatomy, Perugia, Italy Abstract. Liposarcoma is one of the commonest soft-tissue accounting for only 0.3% of all liposarcomas (3-6). A review sarcomas, but very rare in the oral cavity. We present two cases of of the literature regarding liposarcomas with strictly liposarcoma of the oral cavity, together with the related clinical, intraoral location reveals fewer than 100 case reports (3). histopathological and immunohistochemical findings: one Histologically, the World Health Organization (WHO) affecting the cheek of a 62-year-old man and the other the classification distinguishes 5 LS subtypes: well-differentiated gingival maxillary tuber of a 41-year-old woman. At histological with its variants, myxoid, round cell, pleomorphic and examination a diagnosis of liposarcoma was made in both cases. dedifferentiated (2). The commonest subtype is the myxoid In the first case, immunohistochemical analysis revealed intense variant, followed by the well-differentiated, round cell, positivity for p53, MIB-1, MDM2, and focal positivity for S100 dedifferentiated and pleomorphic variants, in that order. Of protein and CD34, but was negative for alpha-smooth muscle the pleomorphic variant only five cases primarily of the oral actin, desmin and CD68. The second case it was intensely cavity have been reported in the English language literature positive for p53, MIB-1, S-100, and focal positive for MDM2, but (6-8) (Table I) and of the dedifferentiated variant in the oral negative for alpha smooth muscle actin, CD34, CD68 and cavity our case is the seventh report (3, 9-12) (Table II).
    [Show full text]
  • Maintenance of Genomic Integrity
    Chapter 1 Recombination Hot-Spots and Defense Players – Maintenance of Genomic Integrity Radhika Pankaj Kamdar and Basuthkar J. Rao Additional information is available at the end of the chapter http://dx.doi.org/10.5772/54016 1. Introduction Internal factors and external agents are a source of constant genomic stress in living organ‐ isms leading to instability in the form of chromosomal deletions, duplications and transloca‐ tions. These erroneous rearrangements of the chromosome alter the normal functioning of the genes harbored on them leading to genetic birth defects, intellectual disabilities, prema‐ ture ageing and even cancer predisposition in humans [1]. Such chromosomal aberrations occur at gaps within the genome or at breakpoint junctions on double stranded DNA motifs known as fragile sites. Preventing or repairing these DNA damages is pivotal for the normal physiological function of a human body. However, prevention or total abolition of DNA damage from an organism is impossible as it is a constant and spontaneous phenomenon occurring in a physiological environment, stalling DNA replication. Therefore, focus on mechanisms that could stabilize such breakage-prone motifs and repair the damage on DNA could grant an insight into understanding and enhancing them for maintenance of ge‐ nomic integrity. 2. Mechanisms of DNA repair Estimation studies suggest that each mammalian cell genome is subject to several hundreds of DNA strand breaks within the normal physiological setting [2]. Hence, prokaryotes and especially eukaryotes are equipped with defense mechanisms against genotoxic stress in or‐ der to constantly repair and restore the genome, bringing the replication process back in or‐ der from its attenuated state.
    [Show full text]
  • Adipocytic Tumors
    1 ADIPOCYTIC TUMORS Benign tumors and reactive conditions Malignant tumors Lipoma Atypical lipomatous tumor/well-differentiated Lipomatosis liposarcoma/dedifferentiated liposarcoma Multiple symmetric lipomatosis (Launois-Bensaude Spindle cell liposarcoma syndrome) Myxoid liposarcoma Asymmetric lipomatosis Pleomorphic liposarcoma Lipomatosis of nerve Adiposis dolorosa Piezogenic pedal papules Fat necrosis of the morbidly obese Nevus lipomatosus superficialis Fibrohistiocytic lipoma Lipofibromatosis Lipoblastoma/lipoblastomatosis Lipoblastoma-like tumor of the vulva Angiolipoma Myolipoma of soft tissue Myelolipoma Chondroid lipoma Spindle cell lipoma Pleomorphic lipoma Hibernoma 1 Benign tumors and reactive conditions LIPOMA Definition Pathology • A benign dermal or subcutaneous mesenchymal Histology tumor composed of mature adult-type adipose tissue • Resemble normal adult-type adipose tissue • Lobules of adipocytes bounded by thin fibrous septa Clinical features • Adipocytes have large single lipid vacuole in their Epidemiology cytoplasm and eccentrically located small nuclei • The most commonly encountered mesenchymal • May show areas of fat necrosis and increased fibrosis tumor after trauma • Majority of patients are adults • No atypia, pleomorphism, mitoses, or • No sex predilection hyperchromasia Presentation Immunohistochemistry/special stains • Most cases are asymptomatic • Adipocytes express S100 protein • Occasionally painful when compressing nerves • Slowly growing, but size is variable Genetic profile • Usually solitary • True
    [Show full text]
  • (12) Patent Application Publication (10) Pub. No.: US 2017/0121347 A1 Chen Et Al
    US 201701 21347A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2017/0121347 A1 Chen et al. (43) Pub. Date: May 4, 2017 (54) AMORPHOUS SOLID FORM OF A BET Publication Classification PROTEIN INHIBITOR (51) Int. Cl. (71) Applicant: Incyte Corporation, Wilmington, DE C07D 49.8/04 (2006.01) (US) C07D 413/04 (2006.01) (52) U.S. Cl. (72) Inventors: Shili Chen, Newark, DE (US); William CPC ......... C07D 498/04 (2013.01); C07D 413/04 Frietze, Kennett Square, PA (US); (2013.01) Zhongjiang Jia, Kennett Square, PA (US); Pingli Liu, Newark, DE (US); Jiacheng Zhou, Newark, DE (US) (57) ABSTRACT (21) Appl. No.: 15/337,202 The present invention relates to an amorphous solid form of (22) Filed: Oct. 28, 2016 (4S)-7-(3,5-dimethylisoxazol-4-yl)-4-pyridin-2-yl-4,5-dihy droimidazo 1.5,4-de(1,4)benzoxazin-2(1H)-one, and pro Related U.S. Application Data cesses for its preparation, which is an inhibitor of BET (60) Provisional application No. 62/248,040, filed on Oct. proteins such as BRD2, BRD3, BRD4, and BRD-t and is 29, 2015. useful in the treatment of various diseases such as cancer. Patent Application Publication May 4, 2017. Sheet 1 of 3 US 2017/O121347 A1 FIGURE 1 XRPD Two-Theta deg) Patent Application Publication May 4, 2017. Sheet 2 of 3 US 2017/O121347 A1 FIGURE 2 DSC 3.3 - f, 8.8 - i \ fiA \ S. ii ' s i \ s St. -- ? . 2S38 \ A- f a36s2.ig 32C N A ---a--- / N Y.
    [Show full text]