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Curriculum Vitae Mirjam Van Der Burg, Phd

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Curriculum Vitae Mirjam Van Der Burg, Phd CV of M. van der Burg May 2014 Curriculum Vitae Mirjam van der Burg, PhD Working address and contact details Department of Immunology Erasmus MC, University Medical Center Rotterdam Wytemaweg 80 3015 CN ROTTERDAM The Netherlands tel. (31)10.7043015 fax (31)10.7044731 e-mail: [email protected] Personal information Date of birth: 6th of July 1974 Place of birth: Rotterdam, The Netherlands Academic education and degrees Sept. 1992 – March 1997 MSc Biochemistry & Molecular biology at Leiden University Cum laude May 1997-December 2001 PhD at Dept. of Immunology, Erasmus University Rotterdam, NL Thesis: “ Recombination processes during human B-cell differentiation ” Promotor: prof. dr. J.J.M. van Dongen; co-promotor: dr. A.W. Langerak Thesis defence: 19 th of June 2002 Appointments since completing PhD 2002-2007 Fixed term at Dept. of Immunology, Erasmus MC as Post Doc with supervision of 1 PhD student and 2 technicians (1.6 fte) and 1-2 students of Medical University or students from HLO 2007- present Tenured term position at Dept. of Immunology, Erasmus MC, since 2009 as Assistant Professor. Supervision of 2 PhD students, 4 technicians (3.0 fte) and 1-2 students of Medical University or Master students and regular international visiting scientists. Description of current research After the PhD, Mirjam van der Burg started her own research group on Primary Immunodeficiencies (PID) at the Department of Immunology, Erasmus MC. The current Workgroup PID consists of 1 post-doc, 1 pediatric immunologist, 2 PhD students, 4 technicians (3.0 fte) and 1-2 students of Medical School or Master students and regular international visiting scientists. The two research lines are: 1. V(D)J recombination and its defects in severe combined immunodeficiency 2. Immunopathological causes and consequences of primary antibody deficiencies (PAD) 1 CV of M. van der Burg May 2014 The main scientific contributions over the past five years were the identification of four new candidate genes for PID, i.e. genes that can be mutated in PID. Genetic defects in two of the new candidate genes were related to severe combined immunodeficiency ( LIG4 and DNA-PKcs ) and link to research line no. 1 and two genes were related to primary antibody deficiencies ( CD19 and CD81 ) which link to research line no. 2. With identification of mutations in CD19 and CD81, a new PAD category of CD19-complex deficiencies or BCR-signaling deficiencies was defined. In addition, the PID group studies immunological processes that are disturbed in PID as disease model for monogenetic defects. The strength of the research group is the combination of basic research on immunological processes and PID. For PID research, diagnostics and patient care in the Erasmus MC, an Immunodeficiency Center has been initiated by the Depts. of Immunology (Dr. M. van der Burg), Pediatrics (Dr. G. Driessen) and Internal Medicine (Prof.dr. P.M. van Hagen), which has been qualified as a Jeffrey Modell Foundation center of Excellence of PID April 2010 based on outstanding PID research and patient care. International activities European consortia - Leader of EuroChimerism Workpackage DNA isolation from low cell numbers (part of project QLRT-2001-01485) 2002 - 2006 - Leader of EuroFlow PID Workpackage (consortium of 7 European PID laboratories) for development of standardized flow cytometric diagnostics for PID (part of EU-LSHB-CT-2006- 018708) 2011 - present International PID workgroups for guidelines and disease definition - Member of the European Society of Immunodeficiencies (ESID) and member of the Working party Genetics. - Participant of international workgroup “International Update on definition of CVID” chaired by Prof. K. Warnatz, Freiburg, Germany. - Participant of international workgroup “Consensus meeting for the diagnosis of combined immunodeficiencies” chaired by Prof. S. Ehl, Freiburg, Germany and Capucine Picard, Paris, France. - Participant and co-author of the Clinical and Laboratory and Standards Institute (CLSI) document I/LA36, Newborn Bloodspot Screening for Severe Combined Immunodeficiency (SCID) by Measurement of T-cell receptor excision circles (TREC). Chairman, dr. W.J. Hannon, Atlanta, GA, USA National and International memberships - Member of the national Workgroup of Immunodeficiencies (WID) and coordinator of the genetic testing for PID candidate genes in the Netherlands - Member of “Jong GR network” (national network of Junior Health Organization) - Member of the Dutch Society for Immunology (NVVI) - Member of the European Society of Immunodeficiencies (ESID) - Member of the European Academy of Allergy and Clinical Immunology (EAACI) Reviewer Reviewer for Blood, Journal of Allergy and Clinical Immunology, Molecular Immunology, Cytometry Part B, Haematologica, Frontiers in Immunology, Journal of Clinical Immunology, Nature reviews in Immunology. Associate-editor Associate-editor of Frontier in Immunology 2 CV of M. van der Burg May 2014 Teaching activities - Clinical immunology for medical students, case discussions (2000-present) - Elective courses on Gene Therapy (2006-2008, 2011- present) - Faculty member of the Master Molecular Medicine (2009-present) Lectures on PID and Critical Research Topics - Master Infection and Immunity: PID lectures, Molecular Technique Practicals (2009- present) - Training for Medical Immunologists on diagnostics of primary Immunodeficiencies (2005- present) - Teacher/Faculty member at European Society of Immunodeficiencies (ESID) Summer School (2011, 2013) - Coordinator “tweedejaarskeuzeonderwijs PID”for medical students (2013 - ) - Coordinator week “antibody deficiencies” in minor Ever thought of doing research (2013-) Co-promotorships/PhD supervision - Menno C. van Zelm – B-cell development and primary antiboyd deficiencies – 20 June 2007 cum laude - Gertjan J.A. Driessen – Immunobiology of Primary Antibody Deficiencies: towards a new classification – 16 October 2013 - Hanna IJspeert – Clinical and immunological diversity of recombination defects – 19 March 2014 Member of PhD thesis defense committee - Annick van de Ven, UMC Utrecht, November 2011 Scholarships and prizes - Best publication award 2010 of the research school Molecular Medicine for the paper A DNA- PKcs mutation in a radiosensitive T-B- SCID patient inhibits Artemis activation and nonhomologous end-joining. Van der Burg et al. J Clin Invest. 2009;119:91-98. - NWO Aspasia Award for talented female scientist (2013) Grant allocations 2005: ZonMW Veni grant 916.56.107 “V(D)J recombination under control” Principle investigator, (€150K, 3 years) 2005: Project “Lokale Productiegebonden Component”: “Zorgvernieuwing voor primaire immunodeficiënties door snellere en doelmatigere diagnostiek” Co-investigator, (€219K, 3 years) 2006: Baxter research grant: “Identification of B-cell differentiation/maturation defects in common variable immunodeficiency (CVID) as powerful tool for a new classification” Principle investigator, (€50K, 2 years) 2008: SSWO project: “Scope on SCID: unraveling clinical and immunogenetic heterogeneity of SCID” Principle investigator, (€220K, 4 years) 2012: Baxter research grant: “Primary Antibody Deficiencies: Early and accurate diagnosis of new patients and identification of new genetic defects” Principle investigator, (€25K, 1.5 years) 2012: ZonMW Vidi grant 016.126.323 “Immune Repertoire in the Picture” Principle investigator (€800K, 5 years) 3 CV of M. van der Burg May 2014 2013: MultiPAD project Baxter Principle investigator together with GJ Driessen (€100K, 3 years) Courses - Cursus Managementvaardigheden (October 2000) - Cursus Leidinggeven (June2001) - Praktisch Project Mananagement (June 2003) - Cursus Probleem management (March 2005) - Cursus WOD art 9 (September 2005) - Cursus academisch Leidinggeven, including financial management (January-June 2007) - Female Career Development Program 9 (October 2012-October 2013) International SCI publications 10 key publications 1. IJspeert H, Driessen GJ, Moorhouse MJ, Hartwig NG, Wolska-Kusnierz B, Kalwak K, Pituch-Noworolska A, Kondratenko I, van Montfrans JM, Mejstrikova E, Lankester AC, Langerak AW, van Gent DC, Stubbs AP, van Dongen JJ, van der Burg M . Similar recombination-activating gene (RAG) mutations result in similar immunobiological effects but in different clinical phenotypes. J Allergy Clin Immunol. 2014;133:1124-1133 e1121. IF:12.0 2. Castiello MC, Bosticardo M, Pala F, Catucci M, Chamberlain N, van Zelm MC, Driessen GJ, Pac M, Bernatowska E, Scaramuzza S, Aiuti A, Sauer AV, Traggiai E, Meffre E, Villa A, van der Burg M . Wiskott-Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans. J Autoimmun. 2014;50:42-50. IF:8.1 3. IJspeert H, Warris A, van der Flier M, Reisli I, Keles S, Chishimba S, van Dongen JJ, van Gent DC, van der Burg M . Clinical spectrum of LIG4 deficiency is broadened with severe dysmaturity, primordial dwarfism, and neurological abnormalities. Hum Mutat. 2013;34:1611-1614. IF:5.2 4. Driessen GJ, Ijspeert H, Weemaes CM, Haraldsson A, Trip M, Warris A, van der Flier M, Wulffraat N, Verhagen MM, Taylor MA, van Zelm MC, van Dongen JJ, van Deuren M, van der Burg M . Antibody deficiency in patients with ataxia telangiectasia is caused by disturbed B- and T-cell homeostasis and reduced immune repertoire diversity. J Allergy Clin Immunol. 2013;131:1367-1375 e1369. IF:12.0 5. Driessen GJ, van Zelm MC, van Hagen PM, Hartwig NG, Trip M, Warris A, de Vries E, Barendregt BH, Pico I, Hop W, van Dongen JJ, van der Burg M . B-cell replication history and somatic
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