DOCSLIB.ORG

Leopoldina News 6|2018

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Leopoldina News 6|2018 Leopoldina news 6|2018 Deutsche Akademie der Naturforscher Leopoldina – German National Academy of Sciences Halle (Saale), 6 December 2018 Following in Alexander von Humboldt’s footsteps STATEMENT P 3 CLASS IV P 5 WORKSHOP P 9 Privacy in times of New members receive Academies advise on digitalisation certificates sustainability Ensuring the protection of Lecture on Empress Maria Support for the United individuals Theresa of Austria Nations’ objectives 06|2018 // LEOPOLDINA NEWS 2 Editorial Dear Members and Friends of the Leopoldina, Fighting the extinction of biological The diversi- species with immediate action ty of plant and animal species Academies present short statement on biodiversity present in ag- ricultural areas in Germany has decreased dra- matically in the past 25 years. This observation served as a spring- board for the short statement “Species decline in the agricultural landscape: What do we know and what can we do?”, a joint publication by the Leopoldina, the Union of the German Academies of Sciences and Humanities and acatech on 24 Octo- ber (see accompanying text), which recommends immediate action for species conservation. Because biodiversity is important An ever increasing number of butterfly species are going extinct. Likewise, the biodiversity of these for ecosystems and agriculture, and insects is decreasing in agricultural landscapes just like that of plants, birds and mammals. species diversity also speaks to most Graphic: Sisters of Design people’s hearts. There have been a lot of discussions The diversity of animal and plant spe- exhaustive use of plant protection pro- and a host of publications in the cies in Germany has been continuously ducts, overfertilisation, and the decline past months about species loss, co- decreasing for years now, particularly of structural diversity which goes hand in lony collapse disorder, monocultu- in the agricultural landscape. Under the hand with the decline of biodiversity. res and plant protection products. In direction of Prof. Dr. Kathrin Böhning- The academy’s recommendations the spring, the Leopoldina also spoke Gaese ML, Prof. Dr. Alexandra-Maria were presented to the public in Berlin on out about the use of plant protection Klein and Prof. Dr. Wolfgang Wägele, 24 October. Experts see a particular need products in its discussion paper “The the academy working group “Biodi- for action in agricultural policy on the Eu- Silent Spring”. So why are we publi- versity in Agricultural Landscape” ropean level and in Germany. Biodiversi- shing yet another paper, one which is released the statement “Species decline ty-friendly cultivation – a central demand currently being developed by the aca- in the agricultural landscape: What do – has to be profitable for farmers. The demy working group Biodiversity for a we know and what can we do?” It also upcoming reform of the European Com- more detailed statement? entered into discussions with represen- mon Agricultural Policy should be used to Because the time left for slowing tatives from the political and agricultu- provide more funding for protecting bio- down the extinction of biological spe- ral sectors. diversity. cies is quickly running out. And be- In the discussion, Hubertus Paetow, cause a societal discussion on such Biodiversity in Germany is not officially President of the German Agricultural So- topics only really takes off once vari- monitored on a national level. Thus, the ciety (DLG) emphasized his association’s ous players are vocal about them. The survey of the state of biodiversity in Ger- recognition of the need for action and ex- Leopoldina’s members and our part- many has been compiled from many dif- pressed its support of the recommenda- ner academies will continue to keep ferent sources using differing standards tions. Dr. Elsa Nickel, Head of the Direc- the conversation about biodiversity and methods. According to the statement, torate-General Nature Conservation and going. For that, they have my since- a massive decline in number of species in Sustainable Use of Natural Resources at rest thanks. May they be heard! Germany and Europe as a whole over the the German Federal Ministry for the En- past 25 years is clearly evident. For ex- vironment, Nature Conservation and Nuc- Please enjoy reading this exciting ample, since 1990, more than 30 percent lear Safety (BMUB), referenced a study of issue. of agricultural landscape birds have been the Soest district that showed more than lost and in the same timeframe, the but- 200 hectares of land under public owner- terfly population has decreased by nearly ship being used for agriculture. She is cal- half. ling for such areas to be used for biodiver- The causes for this decline are mani- sity conservation and wildlife corridors. fold, including the increase in the cultiva- (ca) tion of arable land, the precautionary and STATEMENT SPECIES REDUCTION (GER) 06|2018 // LEOPOLDINA NEWS 3 Taking advantage – protecting privacy Academies present potential actions for protecting data in the age of digitalisation In the past few years, digitalisation has continued to permeate nearly all branches of society and has contributed to significant improvements along the way, including simplified communica- tion both at work and at home, easier access to information and increased potential for analysing large amounts of data, for instance in the research sector. And these are only three of the many areas of application. However, some non-desirable effects have also become increasingly noticeable – par- ticularly in the realm of privacy, since new technologies frequently subvert data protection measures. Our right to privacy is rooted in the Uni- versal Declaration of Human Rights as Graphic: Sisters of Design well as in the Basic Law for the Federal Republic of Germany. After all, having regionally. Rather, they are often available protection and being able to decide for transnationally or globally, posing unique ourselves whom we reveal information to legal challenges. is one of the basic prerequisites of free- Statement “Privacy in the era of dom and a central aspect of a liberal-de- digitalisation” mocratic society. Growing level of risk to individuals' The Leopoldina, the Union of the Ger- privacy man Academies of Sciences and Huma- nities and acatech published a statement Digitalisation comes with an ever gro- on 26 November entitled “Privacy in the wing amount of data being collected and era of digitalisation”, revealing potential processed. By analysing data, particularly technical, legislative and social actions via its interconnectedness with the aid of that could enable us reconcile the benefits machine learning methods, we can recog- of digitalisation with privacy protection. nize correlations that extend well beyond Such actions may include expanding data individuals’ perceptive abilities. However, protection rights and the returning data the growing amounts of data being crea- sovereignty to consumers as well as bet- ted and analysed using digital technolo- ter monitoring algorithms which combine gies also mean a growing level of risk to and analyse data. individuals’ privacy. Furthermore, economic policies need This is exacerbated by a substantial to address issues such as the protection lack of transparency in the use of digital As one of the spokespersons of the working group against oligopolies – a system in which technologies and the management of un- "Big Data – Data protection – Privacy", Klaus- only a few companies dominate the enti- derlying business models. It is generally Robert Müller presented the recent statement of re market. At a more fundamental level not known what data companies gene- the working group about "Privacy in the era of the security of information technology rate, link and forward internally to other digitalisation". Photo: Leopoldina | Johannes Mengel systems does not just constitute the ba- business units or to other companies, or sis of privacy protection, it is also a perti- how machine learning algorithms are de- ent methods for warranting protection nent economic factor for which standards signed. against private companies — the main should be defined. This goes to show that This use of digital technologies brings drivers of digital transformation — must there is a whole array of options available up the fundamental question: To what ex- be ensured. Legislation is compounded for shaping the digital future together. tent can today’s legal regulations maintain by the dissolution of boundaries brought (ew, jm, sw) the current level of privacy protection? In about by new technologies. Digital tech- addition to the protection of individuals nologies, their underlying infrastructures from government authorities, suffici- and the resulting services are not limited STATEMENT PRIVACY (GER) 06|2018 // LEOPOLDINA NEWS 4 Hormone researcher to hold the Timely help for traumatised Leopoldina’s Christmas lecture refugees Jens Claus Brüning receives Carl-Friedrich-von-Weizsäcker-Preis Refugees’ traumatising experiences can At the Leopoldina’s annual be mitigated or avoided altogether. Ef- Christmas lecture on 11 December, fective help for refugees on the basis of Prof. Dr. Jens Claus Brüning ML scientific findings was the topic of the will be honoured with the Carl- event entitled “Traumatised refugees Friedrich-von-Weizsäcker-Preis – immediate response required”, held for his research on the funda- on 5 November at the Berlin-Branden- mentals of obesity and diabetes burg Academy of Sciences and Huma- mellitus. nities (BBAW) in Berlin.
Load more

Recommended publications
  • Föritztalkurier | Amtsblatt Der Gemeinde Föritztal
    Föritztalkurier |Amtsblatt derGemeindeFöritztal Jahrgang 2019 Mittwoch, 25. September 2019 Nummer 11 nzur Ernennung en Michael Eichhor itztal Wirgratulier er Gemeinde För tswegewartd zum neuen Or www.foeritztal.de AMTSBLATTder GemeindeFöritztal |Nr. 11/2019 -2- Inhaltsverzeichnis: Amtlicher Teil der Gemeinde Föritztal Beschlüsse des Gemeinderates Föritztal •Beschluss über die Auftragsvergabe zum Bauvorhaben •Beschluss über die Bestätigung der Tagesordnung Überdachung und Sanierung des Sportlerheims der Sitzung des Gemeinderates Föritztal im OT Mupperg Los 1-Rohbau und Sanierungs- vom12.09.2019 ........................................................ Seite 3 arbeiten..................................................................... Seite 6 •Beschluss über die Niederschrift des öffentlichen Teils •Beschluss über die Auftragsvergabe zum Bauvorhaben der 08. Sitzung des Gemeinderates Föritztal Überdachung und Sanierung des Sportlerheims vom02.07.2019 ........................................................ Seite 3 im OT Mupperg Los 15 -Schlosserarbeiten ............. Seite 6 •Beschluss über die Bestätigung zur Veröffentlichung •Beschluss über die Niederschrift des nicht öffentlichen der in der 08. Sitzung des Gemeinderates Föritztal Teils der 08. Sitzung des Haupt- und Finanzaus- am 02.07.2019 gefassten nicht öffentlichen schusses des Gemeinderates Föritztal Beschlüsse ............................................................... Seite 3 vom23.07.2019 ........................................................ Seite 7 •Beschluss über die
    [Show full text]
  • Differential Synergy of Notch and T Cell Receptor Signaling Determines Αβ
    ARTICLE Diff erential synergy of Notch and T cell receptor signaling determines αβ versus γδ lineage fate Annette I. Garbe,1 Andreas Krueger,1 Fotini Gounari,1,2 Juan Carlos Zúñiga-Pfl ücker,3 and Harald von Boehmer1 1Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02115 2Tufts-New England Medical Center, Boston, MA 02111 3University of Toronto, Toronto, Ontario, M4N 3M5 Canada Thymic precursors expressing the pre–T cell receptor (TCR), the TCR, or the TCR can all enter the CD4+8+ lineage, albeit with different effi cacy. Here it is shown that proliferation and differentiation of precursors with the different TCRs into lineage cells require Notch signaling at the DN3 stage of thymic development. At the DN4 stage, Notch signaling still signifi cantly contributes to the generation of T cells. In particular, in lineage commitment, the pre-TCR synergizes more effi ciently with Notch signals than the other two TCRs, whereas TCR-expressing cells can survive and expand in the absence of Notch signals, even though Notch signaling enhances their proliferation. These observations suggest a new model of versus lineage choice in which lineage fate is determined by the extent of synergy between TCR and Notch signaling and in which the evolutionarily recent advent of the cell-autonomously signaling pre-TCR increased the effi cacy of T cell generation. CORRESPONDENCE The mammalian immune system contains sev- essential for the rescue of DP cells from pro- Harald von Boehmer: eral T lymphocyte lineages of which the grammed cell
    [Show full text]
  • Sitzungsberichte Der Leibniz-Sozietät, Jahrgang 2004, Band 67
    SITZUNGSBERICHTE DER LEIBNIZ-SOZIETÄT Band 67 • Jahrgang 2004 trafo Verlag Berlin ISSN 0947-5850 ISBN 3-89626-493-1 Inhalt 01 Peter Oehme: Einleitung 02 Herbert Hörz: Eine glückliche Verbindung von Person und Funktion 03 Günter Pasternak: Begegnungen mit Werner Scheler 04 Adolf Grisk & Hansgeorg Hüller: Gemeinsame Jahre an der Universität Greifswald 05 Peter Oehme: Ein Pharmakologe und Akademiepolitiker 06 Christiane Jung: Von der Hämkatalyse zum Cytochrom P450 07 Rita Bernhardt: Cytochrom P450 und die Anwendung der Molekularbiologie 08 Werner Scheler: Schlussworte; Anstelle eines Nachwortes Anhang 09 Wissenschaftlicher Werdegang 10 Auswahl bibliografischer Daten Rezensionen 11 Gisela Jacobasch: Moritz Mebel, Gottfried May, Peter Althaus: Der komplette Nierenersatz!? Aufbau und Entwicklung der Nierentransplantation in der DDR 12 Werner Scheler. Athineos Philippu: Geschichte und Wirken der pharmakologischen, klinisch-pharmakologischen und toxikologischen Institute im deutschsprachigen Raum 13 Werner Scheler: Heinz David: Kontinuitäten, Brüche und Abbrüche sowie Neuanfänge in der 300jährigen Geschichte der Medizinischen Fakultät (Charité) der Berliner Universität 14 Nachwort Prof. Dr. sc. med. Drs. hc. Werner Scheler (im Hintergrund Ingeborg Scheler) während des Festkolloquiums am 19. September 2003 Sitzungsberichte der Leibniz-Sozietät 67(2004), 7–9 Mehr als 70 Fachkollegen, ehemalige „Mitstreiter“ und Freunde hatten sich am 19. September diesen Jahres zu einem wissenschaftlichen Kolloquium im Zeiss-Großplanetarium Berlin zusammengefunden,
    [Show full text]
  • Book Reviews This Is Reflected in the Thirty Important Years Hardy Spent
    Book Reviews is part of that broader field of experimental pathology to which all medical sciences belong". This is reflected in the thirty important years Hardy spent as Chairman and Professor in the Department of Surgery at the University of Mississipi in Jackson, where he divided his activities among surgical practice, teaching, and research. The period of his memoirs saw advances in surgical pathology and anaesthesia. Also arterial surgery, open-heart surgery, organ transplantation, and the artificial heart and other prostheses were developed. Following extensive research, including a study ofthe moral problems, his team undertook and recorded the first human lung and heart transplants, in 1963 and 1964 respectively. Hardy was not only an active surgeon, but as an author contributed much to surgical literature. His wide reading, too, he regarded as a form ofeducation. His most gratifying honour was his election as President of the American College of Surgeons in 1980. It is ironic that James Hardy, vascular surgeon, should undergo in 1982 and 1985 carotid endarterectomy. His well-earned retirement allowed him professional rest to enjoy his "closely knit" family life. Valentine Swain Chigwell, Essex VIVIEN T. THOMAS, Pioneering research in surgical shock and cardiovascular surgery. Vivien Thomas and his work with Alfred Blalock, Philadelphia, University of Pennsylvania Press, 1985, 8vo, pp. xx, 245, illus., £29.95. This is a remarkable autobiography by a remarkable man. Owing to "collapse of the Stock Market", this American Negro was unable to proceed to a medical career. Luckily, he became Alfred Blalock's technician first at Vanderbilt University and later at Johns Hopkins University, both in the Experimental Surgery Laboratories.
    [Show full text]
  • Deciphering Thymic Development
    View metadata, citation and similar papers at core.ac.uk brought to you by CORE OPINION ARTICLE published: 08provided October by 2014 Frontiers - Publisher Connector doi: 10.3389/fimmu.2014.00424 Deciphering thymic development Harald Von Boehmer 1,2* 1 Department of Microbiology and Immunobiology, Harvard Medical School, Boston, MA, USA 2 Department of Cancer Immunology and AIDS, Dana-Farber Cancer Institute, Boston, MA, USA *Correspondence: [email protected] Edited by: Kendall A. Smith, Weill Medical College of Cornell University, USA Reviewed by: Herman Waldmann, University of Oxford, UK Keywords: MHC-restricted antigen recognition, T cell clones, TCR alpha/beta cDNA clones, HY antigen, TCR transgenic mice, negative thymic selection, positive thymic selection In 1979, some of us were surprised by beta genes from one T cell clone to asked Hans Georg Rammensee who was the (1) conclusion of Doherty and Zinker- another allowed us to unequivocally con- in the same office a related question. I nagel on MHC-restricted antigen recogni- clude that the MHC-restricted specificity leave it to the audience to imagine what tion following the lead of Katz, Hamaoka, was encoded by a single receptor long Michael Steinmetz told Georges Koehler and Benacerraf (2) describing the same before crystallographic studies reached or better what he did not tell him, even for the interaction of T helper cells with the same conclusion (5). This surprised though one cannot be completely sure of B cells as well as Rosenthal and Shevach some molecular biologists somewhat who it. So Georges did not produce the mice (3) describing it for the interaction of T thought that the cloning of the TCR put but Anton Berns in Amsterdam cooper- cells with macrophages.
    [Show full text]
  • Table of Contents
    Cancer Immunology Research Table of Contents July 2014 Volume 2 Issue 7 EDITORIAL RESEARCH ARTICLES 591 Cancer Immunology Research: A One-Year 616 Immunotherapy Converts Nonimmunogenic Anniversary Pancreatic Tumors into Immunogenic Foci of Immune Regulation Eric R. Lutz, Annie A. Wu, Elaine Bigelow, Rajni Sharma, Guanglan Mo, Kevin Soares, Sara Solt, MASTERS OF IMMUNOLOGY Alvin Dorman, Anthony Wamwea, Allison Yager, Daniel Laheru, Christopher L. Wolfgang, 592 The Thymus in Immunity and in Malignancy Jiang Wang, Ralph H. Hruban, Robert A. Anders, Harald von Boehmer Elizabeth M. Jaffee, and Lei Zheng Synopsis: Lutz and colleagues show that an allogeneic vaccine given with or without low-dose cyclophosphamide converted pancreatic cancer into an immunogenic cancer CANCER IMMUNOLOGY AT THE with infiltrating effector lymphocytes and formation of CROSSROADS: EXPERIMENTAL tertiary lymphoid aggregates that are regulatory structures IMMUNOTHERAPIES of adaptive immunity. 632 598 Hostile, Hypoxia–A2-Adenosinergic Tumor Bevacizumab plus Ipilimumab in Patients with Biology as the Next Barrier to Overcome for Metastatic Melanoma Tumor Immunologists F. Stephen Hodi, Donald Lawrence, Cecilia Lezcano, Xinqi Wu, Jun Zhou, Tetsuro Sasada, Wanyong Zeng, Michail V. Sitkovsky, Stephen Hatfield, Anita Giobbie-Hurder, Michael B. Atkins, Robert Abbott, Bryan Belikoff, Dmitriy Lukashev, Nageatte Ibrahim, Philip Friedlander, and Akio Ohta Keith T. Flaherty, George F. Murphy, Scott Rodig, Elsa F. Velazquez, Martin C. Mihm Jr, Sara Russell, MILESTONES IN CANCER
    [Show full text]
  • Jahrbuch 2018 Leopoldina-Jahrbuch 2018 Leopoldina-Jahrbuch
    Deutsche Akademie der Naturforscher Leopoldina Nationale Akademie der Wissenschaften Jahrbuch 2018 Leopoldina-Jahrbuch 2018 Leopoldina-Jahrbuch Herausgegeben von Jörg Hacker Präsident der Akademie Leopoldina Reihe 3, Jahrgang 64 (2018), Halle (Saale) 2019 Wissenschaftliche Verlagsgesellschaft Stuttgart Leopoldina-Jahrbuch 2018 Jahrbuch 2018 Leopoldina Reihe 3, Jahrgang 64 Herausgegeben von Jörg Hacker Präsident der Akademie Deutsche Akademie der Naturforscher Leopoldina Nationale Akademie der Wissenschaften, Halle (Saale) 2019 Wissenschaftliche Verlagsgesellschaft Stuttgart Redaktion: Dr. Michael Kaasch und Dr. Joachim Kaasch Das Jahrbuch erscheint bei der Wissenschaftlichen Verlagsgesellschaft Stuttgart, Birkenwaldstraße 44, 70191 Stuttgart, Bundesrepublik Deutschland. Das Jahrbuch wird gefördert durch das Bundesministerium für Bildung und Forschung sowie das Ministerium für Wirtschaft, Wissenschaft und Digitalisierung des Landes Sachsen-Anhalt. Bitte zu beachten: Die Leopoldina Reihe 3 bildet bibliographisch die Fortsetzung von: (R. 1) Leopoldina, Amtliches Organ … Heft 1– 58 (Jena etc. 1859 –1922/23) (R. 2) Leopoldina, Berichte … Band 1– 6 (Halle 1926 –1930) Zitiervorschlag: Jahrbuch 2018. Leopoldina (R. 3) 64 (2019) Die Abkürzung ML hinter dem Namen steht für Mitglied der Deutschen Akademie der Naturforscher Leopoldina – Nationale Akademie der Wissenschaften. Die im Jahrbuch angegebenen Internetadressen und Verlinkungen sind zum Zeitpunkt des Erscheinens der Publikation gültig. Spätere Veränderungen durch die Betreiber der Internetseiten
    [Show full text]
  • April 8, 1997, NIH Record, Vol. XLIX, No. 7
    C 0 R a Still The Second Best Thing About Payday Record Debuts on the Web HIGHLIGHTS· From 'Whatchamacallit' to Funshine New Camp Starts for Children The NIH Record, exclusively a paper publication since May 1949, is now Special love Infected with HIV available electronically on the World Wide launches New By Rich McManus Web. It can be accessed within the NIH Camp home page (www.nih.gov) under the nless you just came to NIH a week ago, you probably know at " Information for Employees" and "News Microsoft least something about Camp Fantastic. For the uninitiated, it's and Events" sections. Or open the site Wunderkind ~ a week-long slice of August turned into terrific summer camp directly by going to http://www.nih.gov/ Foretells Future for children-many of them Clinical Center patients-with cancer, news/NIH-Record/archives.htm. and has always been powered by the freehearted and funloving Catch the Record side of the National Cancer Institute-its Pediatric Branch and The Web version is modeled after the on the Web associated caregivers. It began 15 years ago at a 4-H campground paper one and closely resembles it, but has near Front Royal, Va., and has evolved into a year-round, family­ the advantage of color design and centered program that worries not just about the child with photography. The site's opening page is an cancer, but also about the healthy sibling who wonders where all " Archives" of issues that leads off-for the Dyer, Gorgas Talks of mom and dad's attention went.
    [Show full text]
  • Peter Oehme Ein Pharmakologe Und Akademiepolitiker
    Sitzungsberichte der Leibniz-Sozietät 67(2004), 37–47 Peter Oehme Ein Pharmakologe und Akademiepolitiker Sehr geehrter Jubilar, lieber Werner, liebe Frau Sche- ler, liebe Familie Scheler, sehr geehrte Kolleginnen und Kollegen, das heutige Festkolloquium zu Ehren des 80. Geburts- tages von Werner Scheler findet im Rahmen der Leib- niz-Sozietät statt. Dieser Rahmen ist sicher ein richtiger, denn das Wirken des Jubilars ist eng mit dem Namen Gottfried Wilhelm Leibniz verbunden. Das be- trifft zum einen das Leibniz’sche Konzept einer engen Peter Oehme Verbindung von Theorie und Praxis. Das betrifft zum zweiten die Motivation des Handelns von Leibniz: „et- was Greifbares und Nützliches für das allgemeine Wohl zu leisten“. Betrachten wir vor diesem Hintergrund das Leben, das Wirken und das Werk unseres Jubilars, des Pharma- kologen, Akademiepolitikers, Kollegen und Freundes Werner Scheler. Dabei bittet der Vortragende vorab um Verständnis dafür, dass im Mittelpunkt seines Beitrages der Jubilar und nicht die von ihm gestaltete Institution steht und auch dafür, dass der Blickwinkel dieses Bei- trages persönlich und pharmakologisch geprägt ist. Erste bildliche Zeugnisse zeigen den Jubilar am Tag seiner Schuleinführung, gewissermaßen in der akade- mischen – genauer schulischen – „Startphase“ im Jahre 1930. Ort der Handlung ist Steinach, eine Kleinstadt mit etwa 7000 Einwohnern am Südhang des Thüringer Schuleinführung 1930 Waldes. Dieses kleine hübsche Städtchen ist bekannt durch seine Schieferbrüche, Glas-, Holz- und Spielzeugindustrie. Der Vater unseres „Einschülers“ – Karl Scheler – arbeitet als Schlossermeister in einer 38 Peter Oehme Maschinenfabrik des Ortes. Karl Scheler ist ein pflichtbewusster und durch- setzungskräftiger Mann; in seinen Auffassungen eher traditionsbewusst, kon- servativ. Den sich bereits andeutenden Entwicklungen des aufkommenden Nationalsozialismus steht er bald misstrauisch gegenüber.
    [Show full text]
  • Shaping the T Cell Repertoire
    Shaping the T Cell Repertoire Harald von Boehmer J Immunol 2005; 175:7067-7068; ; This information is current as doi: 10.4049/jimmunol.175.11.7067 of September 27, 2021. http://www.jimmunol.org/content/175/11/7067 Downloaded from References This article cites 6 articles, 3 of which you can access for free at: http://www.jimmunol.org/content/175/11/7067.full#ref-list-1 Why The JI? Submit online. http://www.jimmunol.org/ • Rapid Reviews! 30 days* from submission to initial decision • No Triage! Every submission reviewed by practicing scientists • Fast Publication! 4 weeks from acceptance to publication *average by guest on September 27, 2021 Subscription Information about subscribing to The Journal of Immunology is online at: http://jimmunol.org/subscription Permissions Submit copyright permission requests at: http://www.aai.org/About/Publications/JI/copyright.html Email Alerts Receive free email-alerts when new articles cite this article. Sign up at: http://jimmunol.org/alerts Errata An erratum has been published regarding this article. Please see next page or: /content/176/1/677.1.full.pdf /content/176/1/677.2.full.pdf The Journal of Immunology is published twice each month by The American Association of Immunologists, Inc., 1451 Rockville Pike, Suite 650, Rockville, MD 20852 Copyright © 2005 by The American Association of Immunologists All rights reserved. Print ISSN: 0022-1767 Online ISSN: 1550-6606. Shaping the T Cell Repertoire Harald von Boehmer1 Today immunologists are well aware of positive to self. In this hypothesis, the focus on self-MHC was imposed and negative selection of developing T cells.
    [Show full text]
  • Arara, No 11, 2013
    Josep Renau’s Futuro Trabajador del Comunismo An Emblematic Work of the Era of the Scientific-Technical Revolution in the German Democratic Republic1 Oliver Sukrow Fig. 1 Josep Renau Futuro Trabajador del Comunismo, (Boceto No. 3), 1969, tempera on paper and wood, 88 x 65 cm, design for a mural for the Academy of Marxist-Leninist Theory of Organization, not executed, Berlin-Wuhlheide, © IVAM, Instituto Valencià d’Art Modern, Generalitat, Depósito Fundación Renau, Valencia, Spain (source: Karl-Siegbert Rehberg, Wolfgang Holler and Paul Kaiser (eds.): Abschied von Ikarus. Bildwelten in der DDR – neu gesehen, Cologne: Verlag der Buchhandlung Walter König, 2012, p. 234) In 1956, Diego Rivera (1886-1957) visited the German Democratic Republic (GDR) and was appointed as corresponding member of the Academy of Arts, Berlin for his lifetime achievements. When in East Berlin, he was asked to create some murals for the then still partly destroyed capital of the GDR, but neither Rivera nor the other two of Los Tres Grandes –Rivera, David Alfaro Siqueiros (1896-1974), and José Clemente Orozco (1883-1949)– ever executed a mural in Germany. However, in the 1 This paper is part of a PhD project at the Department of European Art History at Heidelberg University (supervisors: Prof. Dr. Henry Keazor and Prof. Dr. Edgar Wolfrum). It was firstly presented in October 2012 at the international conference “Another Modernity? Pictorial worlds of the GDR – Perspectives of a Neubewertung”, held by the Klassik Foundation Weimar. The author would like to thank the editors of ARARA for accepting this paper. arara, no 11, 2013 late 1950s and early 1960s, the Spanish artist Josep Renau (1907-82), who was exiled in Mexico after the Spanish Civil War for about twenty years from 1939 onwards, brought his theoretical and practical experiences with Mexican Muralismo to the GDR.
    [Show full text]
  • Harald Von Boehmer 1942–2018
    obituary Harald von Boehmer 1942–2018 oday, few topics in immunology Notch family of signaling receptors in this receive more attention than efforts malignancy. With colleagues in the lab, Tto detect, induce or reinvigorate the Harald also published important insights immune response to tumors. Although into the mechanisms through which many types of immune cells affect different T cell populations respond to and contribute to anti-tumor immune tumors and destroy pancreatic β -cells. At responses, the initial clinical findings that the same time, he never stopped pursuing electrified the field focused on the T cell. knowledge of the basic mechanisms that Cancer biologists who grabbed the nearest affect T cell development. While in Boston, immunology textbook in an effort to fully his lab described mechanisms that affect comprehend and build upon those initial the development of regulatory T cells in the clinical successes will have quickly realized thymus and the periphery and continued that at their core, such approaches rely on to publish insights into the structure and understanding how T cells recognize and function of the pre-TCR. respond to antigen. What they may not After closing his Boston lab, Harald have realized is how important Harald returned to his alma mater as a guest von Boehmer’s work was in laying the professor at the Institute for Immunology foundation for this understanding. of the Ludwig Maximilian University in Long before translational research was Munich. In his writings during this period, all the rage, Harald charged a segment of between the TCR and peptide–major Harald expressed optimism about the future his lab with investigating how fundamental histocompatibility complex determined of immunological research.
    [Show full text]