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Combined Loss of LAP1B and LAP1C Results in an Early Onset Multisystemic Nuclear Envelopathy
ARTICLE https://doi.org/10.1038/s41467-019-08493-7 OPEN Combined loss of LAP1B and LAP1C results in an early onset multisystemic nuclear envelopathy Boris Fichtman1, Fadia Zagairy1, Nitzan Biran1, Yiftah Barsheshet1, Elena Chervinsky2, Ziva Ben Neriah3, Avraham Shaag4, Michael Assa1, Orly Elpeleg4, Amnon Harel 1 & Ronen Spiegel5,6 Nuclear envelopathies comprise a heterogeneous group of diseases caused by mutations in genes encoding nuclear envelope proteins. Mutations affecting lamina-associated polypep- 1234567890():,; tide 1 (LAP1) result in two discrete phenotypes of muscular dystrophy and progressive dystonia with cerebellar atrophy. We report 7 patients presenting at birth with severe pro- gressive neurological impairment, bilateral cataract, growth retardation and early lethality. All the patients are homozygous for a nonsense mutation in the TOR1AIP1 gene resulting in the loss of both protein isoforms LAP1B and LAP1C. Patient-derived fibroblasts exhibit changes in nuclear envelope morphology and large nuclear-spanning channels containing trapped cytoplasmic organelles. Decreased and inefficient cellular motility is also observed in these fibroblasts. Our study describes the complete absence of both major human LAP1 isoforms, underscoring their crucial role in early development and organogenesis. LAP1-associated defects may thus comprise a broad clinical spectrum depending on the availability of both isoforms in the nuclear envelope throughout life. 1 Azrieli Faculty of Medicine, Bar-Ilan University, Safed, Israel. 2 Genetic Institute, Emek Medical Center, Afula, Israel. 3 Department of Human Genetics, Shaare Zedek Medical Center, Jerusalem, Israel. 4 Monique and Jacques Roboh Department of Genetic Research, Hadassah-Hebrew University Medical Center, Jerusalem, Israel. 5 Department of Pediatrics B’, Emek Medical Center, Afula, Israel. -
Israel-Hizbullah Conflict: Victims of Rocket Attacks and IDF Casualties July-Aug 2006
My MFA MFA Terrorism Terror from Lebanon Israel-Hizbullah conflict: Victims of rocket attacks and IDF casualties July-Aug 2006 Search Israel-Hizbullah conflict: Victims of rocket E-mail to a friend attacks and IDF casualties Print the article 12 Jul 2006 Add to my bookmarks July-August 2006 Since July 12, 43 Israeli civilians and 118 IDF soldiers have See also MFA newsletter been killed. Hizbullah attacks northern Israel and Israel's response About the Ministry (Note: The figure for civilians includes four who died of heart attacks during rocket attacks.) MFA events Foreign Relations Facts About Israel July 12, 2006 Government - Killed in IDF patrol jeeps: Jerusalem-Capital Sgt.-Maj.(res.) Eyal Benin, 22, of Beersheba Treaties Sgt.-Maj.(res.) Shani Turgeman, 24, of Beit Shean History of Israel Sgt.-Maj. Wassim Nazal, 26, of Yanuah Peace Process - Tank crew hit by mine in Lebanon: Terrorism St.-Sgt. Alexei Kushnirski, 21, of Nes Ziona Anti-Semitism/Holocaust St.-Sgt. Yaniv Bar-on, 20, of Maccabim Israel beyond politics Sgt. Gadi Mosayev, 20, of Akko Sgt. Shlomi Yirmiyahu, 20, of Rishon Lezion Int'l development MFA Publications - Killed trying to retrieve tank crew: Our Bookmarks Sgt. Nimrod Cohen, 19, of Mitzpe Shalem News Archive MFA Library Eyal Benin Shani Turgeman Wassim Nazal Nimrod Cohen Alexei Kushnirski Yaniv Bar-on Gadi Mosayev Shlomi Yirmiyahu July 13, 2006 Two Israelis were killed by Katyusha rockets fired by Hizbullah: Monica Seidman (Lehrer), 40, of Nahariya was killed in her home; Nitzo Rubin, 33, of Safed, was killed while on his way to visit his children. -
Migration of Eretz Yisrael Arabs Between December 1, 1947 and June 1, 1948
[Intelligence Service (Arab Section)] June 30, 1948 Migration of Eretz Yisrael Arabs between December 1, 1947 and June 1, 1948 Contents 1. General introduction. 2. Basic figures on Arab migration 3. National phases of evacuation and migration 4. Causes of Arab migration 5. Arab migration trajectories and absorption issues Annexes 1. Regional reviews analyzing migration issues in each area [Missing from document] 2. Charts of villages evacuated by area, noting the causes for migration and migration trajectories for every village General introduction The purpose of this overview is to attempt to evaluate the intensity of the migration and its various development phases, elucidate the different factors that impacted population movement directly and assess the main migration trajectories. Of course, given the nature of statistical figures in Eretz Yisrael in general, which are, in themselves, deficient, it would be difficult to determine with certainty absolute numbers regarding the migration movement, but it appears that the figures provided herein, even if not certain, are close to the truth. Hence, a margin of error of ten to fifteen percent needs to be taken into account. The figures on the population in the area that lies outside the State of Israel are less accurate, and the margin of error is greater. This review summarizes the situation up until June 1st, 1948 (only in one case – the evacuation of Jenin, does it include a later occurrence). Basic figures on Arab population movement in Eretz Yisrael a. At the time of the UN declaration [resolution] regarding the division of Eretz Yisrael, the following figures applied within the borders of the Hebrew state: 1. -
Faculty for Medicin in Tzfat Orientation Guide
WELCOME! Welcome to the Azrieli Faculty of Medicine, Bar-Ilan University, Safed PRE-ARRIVAL Visa Every incoming student arriving to Israel, including post-doctoral fellows, must arrange for a student visa (A/2 visa) at their local Israeli consulate prior to their arrival in Israel. Please present your acceptance letter from the Graduate School as well as a support letter from the faculty / your PI when applying for a visa. A list of Israeli consulates around the world can be found here: https://embassies.gov.il/Pages/IsraeliMissionsAroundTheWorld.aspx. * For renewing your visa while in Israel, please contact the academic secretary (Ms. Nurith Maor [email protected]) 1.5 months prior to its expiry date. She will assist you with scheduling an appointment at the Ministry of Interior office in Safed. Health Insurance Every international student must obtain a health insurance policy for the duration of their stay in Israel, prior to their arrival (you will also be requested to present your health insurance for the visa application). Once in Israel, you may decide whether to continue your health insurance from your home country or to buy a local health insurance policy. There is no obligation to work with a specific insurance provider, however we recommend contacting “Harel-Yedidim” – with comprehensive experience handling the insurance needs of international students, and 24/7 English-speaking assistance. For more information on Harel-Yedidim see here https://biuinternational.com/wp- content/uploads/2019/01/Health-insurance-procedures.pdf and/or visit their website, http://www.yedidim-health.co.il/ More information regarding the coverage can be found here https://biuinternational.com/wp- content/uploads/2018/11/Summary-of-coverages-UMS-Policy.pdf (for a basic summary of the coverage) and here https://biuinternational.com/wp-content/uploads/2018/12/UMS-Policy.pdf (for the full policy). -
Short Bios251011.Pdf
יום עיון בנושא @ יום שלישי, כ“ז בתשרי תשע“ב, 25.10.2011 מלון דן אכדיה, הרצליה האקדמיה הלאומית פדגוגיה הישראלית למדעים בעידן המידע היזמה למחקר יישומי בחינוך הוועדה לנושא מחקר מתווה-דרך: הצעה לארגון לימודים מחודש קורות חיים ליום עיון "פדגוגיה בעידן המידע" שמות המשתתפים והגופים שהם מייצגים מופיעים כאן לפי סדר הא"ב: אלי איזנברג סמנכ"ל בכיר למחקר-ופיתוח ולהכשרה ברשת אורט ישראל. בעבר היה חבר סגל בטכניון וחוקר באוניברסיטה הפתוחה באנגליה, וכן הקים מרכז טכנולוגי באנגליה ומערכת חינוך טכנולוגי מקיפה מטעם אורט העולמי בדרום-אפריקה. במסגרות אלה עסק ד"ר איזנברג במחקר, בפיתוח, ביישום ובהערכה של תכניות לימודים, בהסבת מורים והכשרתם לתעודות ולתארים, בפיתוח והטמעה של חומרי למידה (חומרה, לומדה, תוכנה) ובמחקר-ופיתוח של מודלים להנחיה ולסיוע ביישום החינוך הטכנולוגי ברמות השונות בבתי ספר, במכללות ובמערכות הדרכה בתעשייה. ד"ר איזנברג הוא בעל ניסיון של 22 שנים בהכשרת מורים, בהסבת מהנדסים ובהוראה למגוון אוכלוסיות תלמידים, מטעוני טיפוח ועד נוער מחונן. הוא פרסם עשרות מאמרים מקצועיים בעיתונות מקצועית ובכנסים מדעיים, וכתב ספרי לימוד להכשרת מורים בחינוך הטכנולוגי. בעל תואר שלישי בחינוך טכנולוגי מהטכניון בחיפה. מיכל בלר מייסדת הרשות הארצית למדידה והערכה בחינוך (ראמ"ה), שבראשה היא עומדת. תחום התמחותה העיקרי הוא מדידה והערכה חינוכית. עד כניסתה לתפקידה הנוכחי שימשה מנהלת מחקר בכירה במחלקת המחקר והפיתוח של מכון המבחנים הגדול בעולם - ETS Educational Testing Service, בפרינסטון, ניו-ג'רזי (ארצות הברית). לפני כן עמדה בראש המרכז הארצי לבחינות ולהערכה (מיסוֹדן של האוניברסיטאות בישראל), והייתה פרופסור-חבר במחלקה לחינוך ופסיכולוגיה באוניברסיטה הפתוחה, שם גם הקימה וניהלה את מרכז שה"ם (שילוב טכנולוגיות בהוראה מרחוק). בעלת תואר שלישי בפסיכולוגיה מהאוניברסיטה העברית בירושלים, 1982. -
Unilever Annual Report & Accounts
DISCLAIMER This is a PDF version of the Annual Report on Form 20-F 2018 and is an exact copy of the document filed with the SEC at www.sec.gov. Certain sections of the Annual Report on Form 20-F 2018 have been audited. These are on pages 75 to 127 and the Guarantor Statements on pages 158 to 162. The maintenance and integrity of the Unilever website is the responsibility of the Directors; the work carried out by the auditors does not involve consideration of these matters. Accordingly, the auditors accept no responsibility for any changes that may have occurred to the financial statements since they were initially placed on the website. Legislation in the United Kingdom and the Netherlands governing the preparation and dissemination of financial statements may differ from legislation in other jurisdictions. Except where you are a shareholder, this material is provided for information purposes only and is not, in particular, intended to confer any legal rights on you. This Annual Report on Form 20-F does not constitute an invitation to invest in Unilever shares. Any decisions you make in reliance on this information are solely your responsibility. The information is given as of the dates specified, is not updated, and any forward-looking statements are made subject to the reservations specified in the cautionary statement on the inside back cover of the Annual Report on Form 20-F 2018. Unilever accepts no responsibility for any information on other websites that may be accessed from this site by hyperlinks. MAKING SUSTAINABLE LIVING COMMONPLACE ANNUAL REPORT ON FORM 20-F 2018 ANNUAL REPORT ON CONTENTS FORM 20-F 2018 Strategic Report .............................................................................. -
Rocument RESUME ED 045 767 UD 011 084 Education in Israel3
rOCUMENT RESUME ED 045 767 UD 011 084 TITLE Education in Israel3 Report of the Select Subcommittee on Education... Ninety-First Congress, Second Session. INSTITUTION Congress of the U.S., Washington, E.C. House Ccmmittee on Education and Labcr. PUB DATE Aug 70 NOTE 237p. EDRS PRICE EDRS Price MP-$1.00 BC-$11.95 DESCRIPTORS Acculturation, Educational Needs, Educational Opportunities, *Educational Problems, *Educational Programs, Educational Resources, Ethnic Groups, *Ethnic Relations, Ncn Western Civilization, Research and Development Centers, *Research Projects IDENTIFIERS Committee On Education And Labor, Hebrew University, *Israel, Tel Aviv University ABSTRACT This Congressional Subcommittee report on education in Israel begins with a brief narrative of impressions on preschool programs, kibbutz, vocational programs, and compensatory programs. Although the members of the subcommittee do not want to make definitive judgments on the applicability of education in Israel to American needs, they are most favorably impressed by the great emphasis which the Israelis place on early childhood programs, vocational/technical education, and residential youth villages. The people of Israel are considered profoundly dedicated to the support of education at every level. The country works toward expansion of opportunities for education, based upon a belief that the educational system is the key to the resolution of major social problems. In the second part of the report, the detailed itinerary of the subcommittee is described with annotated comments about the places and persons visited. In the last part, appendixes describing in great depth characteristics of the Israeli education system (higher education in Israel, education and culture, and the kibbutz) are reprinted. (JW) [COMMITTEE PRINT] OF n. -
A Skills Beyond School Review of Israel OECD Reviews of Vocational
OECD Reviews of Vocational Education and Training Training and Education Vocational of Reviews OECD A Skills beyond School Review of Israel OECD Reviews of Vocational Higher level vocational education and training (VET) programmes, are facing rapid Education and Training change and intensifying challenges. What type of training is needed to meet the needs of changing economies? How should the programmes be funded? How should they be linked to academic and university programmes? How can employers and unions be A Skills beyond School engaged? The country reports in this series look at these and other questions. They form part of Skills beyond School, the OECD policy review of postsecondary vocational education and training. Review of Israel Contents Pauline Musset, Małgorzata Kuczera and Simon Field Chapter 1. Introduction and initial assessment Chapter 2. Tackling the skills challenge Chapter 3. Strengthening co-ordination and social partner engagement Chapter 4. Building an effective framework of work-based learning Chapter 5. Building pathways of access and opportunity for vocational students Chapter 6. Developing a dual-skilled teaching workforce Further reading OECD (2010), Learning for Jobs, OECD Reviews of Vocational Education and Training, OECD Publishing. A Skills beyond School Review of Israel See also www.oecd.org/education/vet. For more information about OECD work on skills, see http://skills.oecd.org. Consult this publication on line at http://dx.doi.org/10.1787/9789264210769-en. This work is published on the OECD iLibrary, which gathers all OECD books, periodicals and statistical databases.Visit www.oecd-ilibrary.org for more information. ISBN 978-92-64-21075-2 91 2014 02 1 P 9HSTCQE*cadfje+ OECD Reviews of Vocational Education and Training A Skills beyond School Review of Israel Pauline Musset, Małgorzata Kuczera and Simon Field This work is published on the responsibility of the Secretary-General of the OECD. -
ORT PH List Numerical
The Central Archives for the History of the Jewish People Jerusalem (CAHJP) ORT PHOTO COLLECTION – ORT/Ph ORT (organization for rehabilitation and training) was founded in 1880 as a Russian, Jewish organization to promote vocational training of skilled trades and agriculture and functioned there until the outbreak of World War I, which together with the Bolshevik Revolution caused a virtual cessation of its activities. In 1920 ORT was reestablished in Berlin as an international organization and began operating in Russia and the countries that had formerly been part of Russia – Poland, Lithuania, Latvia, Bessarabia – as well as in Germany, France, Bulgaria, Romania and Hungary. When the Nazis came to power in 1933, the offices were moved from Berlin to Paris and subsequently to Marseilles after the capture of Paris by the Germans in 1940. After World War II the headquarters of World ORT Union were set up in Genève, from which they later moved to London, where they reside to this day. The list below is arranged according to serial numbers each of which represents a country. The sequencing is based on the original order of photos inside the former metal binders, hence towns within a country are listed randomly, not alphabetically. Displaying the photo collection of the ORT files from the headquarters in London, most of the descriptions are the original captions from the former binders. LIST OF REFERENCE CODES NUMERICAL ORT/PH 1 Algeria ORT/PH 13 Tunisia ORT/PH 2 Germany ORT/PH 14 South Africa ORT/PH 3 Austria ORT/PH 1 5 Uruguay ORT/PH 4 -
Renewable Energy – Green and Profitable Is Possible Green Building in Israel Brings Home Renewable Energy
No. 6 | December 5, 2014 Innovation Industry & Science The State of Israel – Promoting and Securing Innovative Green Energy Solutions Arava Power Company – Eventful Year of New Projects Nation-E – Making Energy Cyber Security Affordable Shikun & Binui Renewable Energy – Green and Profitable Is Possible Green building in Israel brings home renewable energy Green building and renewable energy in Israel Very quietly, without expending too much energy, hundreds of buildings are going up that are in the process of receiving green building certification. The Israeli green building standard No. 5281 validates the building’s energy efficiency. The field of green building in Israel provides opportunities for RE developers to streamline energy efficiency in buildings and turn them into energy producers. Green building and RE are two integrated fields aiming to create buildings that are healthier and more environmentally friendly. Developers, let’s build homes that produce energy themselves. www.sviva.gov.il You’re invited to take part- the future is in green building. Contents 04 Another Year and Still "Almost There…" | By Jon Cohen 08 The New Pioneers 10 Energy Cyber Security Needs to be Affordable... 19 We Seek Energy Projects with Attractive Risk/Reward Profile – Investments that “Make Sense” 24 The German-Israeli Chamber of Commerce on the Latest Trends in Making Municipal Services Greener | By Benjamin Friedländer and Gregor Schlosser * All interviews, except Shikun&Binui or if else mentioned, were conducted by Uri Schlesinger Dear Readers, -
The STEM Pipeline in Israel
From Early Learning to Workforce The STEM pipeline in Israel Written by Lea Landman, Policy consultant Professional Review by Dr. Eli Eisenberg, Senior Deputy Director General and Head of Research, Development and Training in ORT Israel Submitted by 1 We hope that the report combined with the hard work of a mosaic of funders, the government, and providers will provide significant resources and inspire deep conversations, ultimately resulting in ensuring even greater impact on STEM in Israel. The Samueli Foundation is a leading philanthropic partner in developing large-scale Science, Technology, Engineering and Mathematics (STEM) initiatives involving education, workforce development, and professional development across systems with diverse stakeholders. In the past year, we have worked together with communities across the United States to help drive conversations that are reshaping the vision of STEM. Discussion and planning that include students, teachers, parents, government, funders, and business and focus on how to cultivate cross-platform, collaborative systems beginning from early learning up thru workforce. Much of this work relies on understanding the STEM landscape in the communities - mapping assets, identifying strengths, opportunities, and gaps. That is why we are excited to work with Beyachad: Stella and Yoel Carasso Family Foundation in partnership with The Rashi Foundation, Jewish Funders Network and Sheatufim to support an environmental scan of STEM assets in Israel. The report and its findings are critical to understanding the STEM landscape – successes, opportunities, strategies and challenges in building out the STEM pipeline in Israel. We hope that the report combined with the hard work of a mosaic of funders, the government, and providers will provide significant resources and inspire deep conversations, ultimately resulting in ensuring even greater impact on STEM in Israel. -
Israeli Settler-Colonialism and Apartheid Over Palestine
Metula Majdal Shams Abil al-Qamh ! Neve Ativ Misgav Am Yuval Nimrod ! Al-Sanbariyya Kfar Gil'adi ZZ Ma'ayan Baruch ! MM Ein Qiniyye ! Dan Sanir Israeli Settler-Colonialism and Apartheid over Palestine Al-Sanbariyya DD Al-Manshiyya ! Dafna ! Mas'ada ! Al-Khisas Khan Al-Duwayr ¥ Huneen Al-Zuq Al-tahtani ! ! ! HaGoshrim Al Mansoura Margaliot Kiryat !Shmona al-Madahel G GLazGzaGza!G G G ! Al Khalsa Buq'ata Ethnic Cleansing and Population Transfer (1948 – present) G GBeGit GHil!GlelG Gal-'A!bisiyya Menara G G G G G G G Odem Qaytiyya Kfar Szold In order to establish exclusive Jewish-Israeli control, Israel has carried out a policy of population transfer. By fostering Jewish G G G!G SG dGe NG ehemia G AGl-NGa'iGmaG G G immigration and settlements, and forcibly displacing indigenous Palestinians, Israel has changed the demographic composition of the ¥ G G G G G G G !Al-Dawwara El-Rom G G G G G GAmG ir country. Today, 70% of Palestinians are refugees and internally displaced persons and approximately one half of the people are in exile G G GKfGar GB!lGumG G G G G G G SGalihiya abroad. None of them are allowed to return. L e b a n o n Shamir U N D ii s e n g a g e m e n tt O b s e rr v a tt ii o n F o rr c e s Al Buwayziyya! NeoG t MG oGrdGecGhaGi G ! G G G!G G G G Al-Hamra G GAl-GZawG iyGa G G ! Khiyam Al Walid Forcible transfer of Palestinians continues until today, mainly in the Southern District (Beersheba Region), the historical, coastal G G G G GAl-GMuGftskhara ! G G G G G G G Lehavot HaBashan Palestinian towns ("mixed towns") and in the occupied West Bank, in particular in the Israeli-prolaimed “greater Jerusalem”, the Jordan G G G G G G G Merom Golan Yiftah G G G G G G G Valley and the southern Hebron District.