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Eye Insights 9.Pdf Oculoplastics Disorders Primary Acquired Nasolacrimal Duct Obstruction Orbital Inflammatory Syndrome INSIDE: • Two Common Oculoplastics Disorders • Diagnosis and Treatment • Referral Guidelines eyeeye InsightsInsightsTM Dear Colleagues, As ophthalmologists, one of the most exciting facets of our profession is our role as problem-solvers. Some of our patients have typical complaints and clear signs pointing to their pathologies, while others have complex, multifactorial problems, often connected to underlying systemic conditions that require all of our clinical skills and knowledge to accurately diagnose and treat. In this issue of eye Insights, we take a close look at two common oculoplastics disorders seen in ophthalmology practice: primary acquired nasolacrimal duct obstruction (PANDO) and orbital inflammatory syndrome (OIS). Inside, you’ll find key information about how PANDO and OIS are diagnosed and treated, guidance on when to refer a patient, and further reading. Keep in mind that ophthalmic plastic surgery is a unique specialty that relies on a surgeon’s technical ability and artistic skill. For a list of doctors that specialize in this type of surgery, please visit the website for the American Society of Ophthalmic Plastic & Reconstructive Surgery. We hope you find this issue of eye Insights useful in your practice. Back issues are available online at masseyeandear.org. If you have questions or comments, please email us at [email protected]. Joan W. Miller, MD David Glendenning Cogan Professor of Ophthalmology and Chair, Department of Ophthalmology Harvard Medical School Chief of Ophthalmology, Massachusetts Eye and Ear and Massachusetts General Hospital Ophthalmologist-in-Chief, Brigham and Women’s Hospital Lacrimal gland Canaliculus Lacrimal sac Nasolacrimal duct TWO COMMON OCULOPLASTICS DISORDERS Primary Acquired Nasolacrimal Duct Obstruction (PANDO) • PANDO is a condition in which chronic inflammation and scarring block the tear drainage system without another identifiable cause for the obstruction, such as trauma, tumor, etc. Patients with PANDO usually seek help when tears overflow. Patients with obstructions are also at risk for infection of the nasolacrimal system. Orbital Inflammatory Syndrome (OIS) • OIS refers to noninfectious inflammation of the orbital tissues—the lacrimal gland (dacryoadenitis), extraocular muscles (myositis), and sclera (scleritis)—or diffuse inflammation and/or a combination of any of these tissues. The inflammation may be idiopathic or may be secondary to a bona fide inflammatory condition, such as sarcoidosis, granulomatosis with polyangiitis, IgG4-related disease, and others. • Patients with OIS often seek help because their eyelids and the area around their eyes are red, swollen, and painful. The eye may be protruding. Vision problems, including double vision and a decrease of vision, can occur. • The gold standard for diagnosis is irrigation • Maxillofacial CT scan is considered for • Dacryocystorhinostomy (DCR) surgery is the primary • All patients diagnosed • Woog JJ. The incidence Daniel R. Lefebvre, MD, FACS of saline through the tear drainage certain cases—such as young adults, treatment for PANDO. Surgeons direct the lacrimal with PANDO should be of symptomatic system via a lacrimal cannula through the those with a history of maxillofacial trauma sac to drain into the nasal cavity in a slightly different referred to an oculoplastic acquired lacrimal Assistant Professor of Ophthalmology, punctum and canaliculi. Passage of saline or malignancy, and those with severe location, bypassing the obstruction. DCR resolves surgeon with expertise outflow obstruction Harvard Medical School through the system into the nasal cavity chronic rhinosinusitis—to determine if tearing and infection in more than 90% of patients. in lacrimal surgery. among residents of confirms that the system is patent. Reflux concurrent functional sinus surgery may Ophthalmologists are Olmsted County, from the opposing punctum indicates an be appropriate. • DCR surgery may be performed traditionally via also encouraged to refer Minnesota, 1976–2000 Ophthalmic Plastic Surgery Service obstruction. a small skin incision by the inner lower eyelid area PANDO suspects who (An American at Mass. Eye and Ear • Nasal endoscopy may reveal problems that heals very well, or via an intranasal endoscopic require advanced testing Ophthalmological • Diagnosis of acute or chronic infection in the nasal cavity requiring surgery, approach. These techniques yield equivalent success for an accurate diagnosis. Society Thesis). of the tear drainage system confirms a such as a deviated nasal septum, chronic rates, and either technique may be appropriate Trans Am Ophthalmol diagnosis of PANDO. This is diagnosed rhinosinusitis, concha bullosa (air pocket in based on surgeon experience and potential need Soc. 2007;105: by visualizing an enlarged and inflamed the middle concha), tumor, or scarring. for other intranasal procedures (such as septoplasty 649-666. lacrimal sac or discharge coming from the or sinus surgery). puncta when pressure is applied on the • Another test for PANDO is to trace the lacrimal sac. movement of dye through the lacrimal drainage system in one of two ways: 1) dacryocystography, where dye is injected in the tear duct and traced with X-ray and/ or CT scan, or 2) dacryoscintigraphy, where a radiotracer eye drop is placed in the conjunctival cul-de-sac and its movement is recorded over time through a series of gamma camera images. ASK THE EXPERT DIAGNOSIS TREATMENT REFERRAL FURTHER OPTIONS GUIDELINES READING TM Spring 2019 • As part of a thorough history, it’s etiologies are not found with laboratory • In very mild cases, observation may often be the • Any patient with orbital • Lefebvre DR, eye Insights important to ask about the use of testing or other less invasive testing. first choice. inflammation should Reinshagen KL, medications associated with OIS, such The histopathology may demonstrate be referred to an orbit Yoon MK, et al. Editor-in-Chief: Ophthalmology Suzanne Freitag, MD • Oral NSAIDs are commonly used as first-line therapy Joan W. Miller, MD Communications: as bisphosphonates taken for the specific signs, such as granulomatous specialist. Treatment An 18-year-old man Suzanne Ward, director in mild cases. Managing Editor: treatment of osteoporosis. inflammation (as in either sarcoidosis or can be complex, with diplopia and Rosa Rojas, manager Associate Professor of Ophthalmology, granulomatosis with polyangiitis) or a high encompassing therapies proptosis of the left Matthew F. Gardiner, MD • Systemic corticosteroid therapy (oral prednisone) Elizabeth DiVito, editor Harvard Medical School • A comprehensive ophthalmic evaluation number of IgG4 plasma cells (as in IgG4- for systemic disease, as eye. N Engl J Med. Clinical Advisory Group: is performed. Pain can be an important is used in many cases of typical dacryoadenitis Deeba Husain, MD Illustration: related disease). well as corticosteroids, 2018;379(25):2452- Eye diagram by or myositis. A taper is typically Ankoor S. Shah, MD, PhD symptom of OIS, particularly in myositis surgery, and radiation. 2461. Laurel Cook Lhowe Director, Ophthalmic Plastic Surgery and dacryoadenitis. It’s important to rule To rule out infection or systemic disease, performed over six to eight weeks, Contributors: The orbit specialist Photography: and is tailored to the patient’s Suzanne Freitag, MD Service, and Co-Director, Center for out infectious orbital cellulitis, which in clinicians might order these additional tests: typically coordinates • Lefebvre DR, Licensed from istock.com improvement in signs and Daniel R. Lefebvre, MD, FACS Thyroid Eye Disease and Orbital Surgery the vast majority of cases originates from care with other specialties, Mandeville JT, Tulips by jimfeng paranasal sinusitis. • A complete blood count and basic symptoms. Yonekawa Y, et al. at Mass. Eye and Ear such as rheumatology, Design: Background by IrisImages metabolic panel A case series J Sherman Studio • Second-line to meet all of the Prednisone molecule by ollaweila • Most often an orbital CT scan with and review of • Thyroid studies: free T4, T3, thyroid immunosuppressive patient’s needs. Woman with tears by skynesher contrast will clearly image the orbit and bisphosphonate- peroxidase antibody (TPO), thyroid- therapies (cyclosporine, paranasal sinuses and aid in the diagnosis. associated orbital stimulating hormone (TSH), thyroid- cyclophosphamide, A CT scan is typically preferred as the inflammation. Ocul stimulating immunoglobulin (TSI), tacrolimus, methotrexate, rituximab, and others) Published biannually, eye Insights offers the ophthalmology initial imaging modality of choice as Immunol Inflamm. and thyrotrophin-binding inhibitor are often used for OIS linked to systemic conditions community best practice information from Mass. Eye and Ear it is quickly obtained, has high spatial 2016;24(2):134-139. specialists. resolution, and shows bony anatomy immunoglobulin (TBII) as well as for sclerosing OIS. We welcome your feedback. Send comments to: in detail that is important in cases • Kubota T. [email protected] • Tests for antinuclear antibodies, • Other options include orbital radiation therapy of infection or malignancy. MRI can Corticosteroids or antineutrophil cytoplasmic antibodies, and, very rarely, surgical debulking. subsequently be obtained if needed to biopsy for idiopathic angiotensin converting enzyme, rapid augment the workup. orbital inflammation. plasma reagent, rheumatoid factor, and Surv Ophthalmol. quantiferon gold (T-spot) to rule out • An orbital biopsy helps to confirm the 2017;62(2):253-255. diagnosis of OIS in cases in which other tuberculosis. .
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