Eye External Anatomy of Eye Accessory Structures
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12 Retina Gabriele K
299 12 Retina Gabriele K. Lang and Gerhard K. Lang 12.1 Basic Knowledge The retina is the innermost of three successive layers of the globe. It comprises two parts: ❖ A photoreceptive part (pars optica retinae), comprising the first nine of the 10 layers listed below. ❖ A nonreceptive part (pars caeca retinae) forming the epithelium of the cil- iary body and iris. The pars optica retinae merges with the pars ceca retinae at the ora serrata. Embryology: The retina develops from a diverticulum of the forebrain (proen- cephalon). Optic vesicles develop which then invaginate to form a double- walled bowl, the optic cup. The outer wall becomes the pigment epithelium, and the inner wall later differentiates into the nine layers of the retina. The retina remains linked to the forebrain throughout life through a structure known as the retinohypothalamic tract. Thickness of the retina (Fig. 12.1) Layers of the retina: Moving inward along the path of incident light, the individual layers of the retina are as follows (Fig. 12.2): 1. Inner limiting membrane (glial cell fibers separating the retina from the vitreous body). 2. Layer of optic nerve fibers (axons of the third neuron). 3. Layer of ganglion cells (cell nuclei of the multipolar ganglion cells of the third neuron; “data acquisition system”). 4. Inner plexiform layer (synapses between the axons of the second neuron and dendrites of the third neuron). 5. Inner nuclear layer (cell nuclei of the bipolar nerve cells of the second neuron, horizontal cells, and amacrine cells). 6. Outer plexiform layer (synapses between the axons of the first neuron and dendrites of the second neuron). -
Permeability of the Retina and RPE-Choroid-Sclera to Three Ophthalmic Drugs and the Associated Factors
pharmaceutics Article Permeability of the Retina and RPE-Choroid-Sclera to Three Ophthalmic Drugs and the Associated Factors Hyeong Min Kim 1,†, Hyounkoo Han 2,†, Hye Kyoung Hong 1, Ji Hyun Park 1, Kyu Hyung Park 1, Hyuncheol Kim 2,* and Se Joon Woo 1,* 1 Department of Ophthalmology, Seoul National University College of Medicine, Seoul National University Bundang Hospital, Seongnam 13620, Korea; [email protected] (H.M.K.); [email protected] (H.K.H.); [email protected] (J.H.P.); [email protected] (K.H.P.) 2 Department of Chemical and Biomolecular Engineering, Sogang University, Seoul 04107, Korea; [email protected] * Correspondence: [email protected] (H.K.); [email protected] (S.J.W.); Tel.: +82-2-705-8922 (H.K.); +82-31-787-7377 (S.J.W.); Fax: +82-2-3273-0331 (H.K.); +82-31-787-4057 (S.J.W.) † These authors contributed equally to this work. Abstract: In this study, Retina-RPE-Choroid-Sclera (RCS) and RPE-Choroid-Sclera (CS) were prepared by scraping them off neural retina, and using the Ussing chamber we measured the average time– concentration values in the acceptor chamber across five isolated rabbit tissues for each drug molecule. We determined the outward direction permeability of the RCS and CS and calculated the neural retina permeability. The permeability coefficients of RCS and CS were as follows: ganciclovir, 13.78 ± 5.82 and 23.22 ± 9.74; brimonidine, 15.34 ± 7.64 and 31.56 ± 12.46; bevacizumab, 0.0136 ± 0.0059 and 0.0612 ± 0.0264 (×10−6 cm/s). -
Altered Hyaluronic Acid Content in Tear Fluid of Patients with Adenoviral Conjunctivitis
Anais da Academia Brasileira de Ciências (2015) 87(1): 455-462 (Annals of the Brazilian Academy of Sciences) Printed version ISSN 0001-3765 / Online version ISSN 1678-2690 http://dx.doi.org/10.1590/0001-3765201520140122 www.scielo.br/aabc Altered hyaluronic acid content in tear fluid of patients with adenoviral conjunctivitis JULIANA L. DREYFUSS1,2*, CAIO V. REGATIERI1,3,5*, BRUNO COELHO1, JOSÉ B. BARBOSA3, DENISE DE FREITAS3, HELENA B. NADER1 and JOÃO R. MARTINS1,4 1Departamento de Bioquímica, Disciplina de Biologia Molecular, Universidade Federal de São Paulo, Rua Três de Maio, 100, 4º andar, 04044-020 São Paulo, SP, Brasil 2Departamento de Informática em Saúde, Grupo Interdisciplinar de Ciências Exatas em Saúde, Universidade Federal de São Paulo, Rua Botucatu, 862, 04023-062 São Paulo, SP, Brasil 3Departamento de Oftalmologia, Universidade Federal de São Paulo, Rua Botucatu, 821, 04023-062 São Paulo, SP, Brasil 4Departamento de Medicina, Disciplina de Endocrinologia, Universidade Federal de São Paulo, Rua Borges Lagoa, 800, 04038-001 São Paulo, SP, Brasil 5Department of Ophthalmology, New England Eye Center, Tufts Medical Center, 800 Washington Street, 02111 Boston, MA, USA Manuscript received on March 13, 2014; accepted for publication on October 24, 2014 ABSTRACT The adenoviral conjunctivitis is one of the biggest causes of conjunctival infection in the world. Conjunctivitis causes relatively nonspecific symptoms, as hyperaemia and chemosis. Even after biomicroscopy, complex laboratory tests, such as viral culture, are necessary to identify the pathogen or its etiology. To contribute to the better understanding of the pathobiology of the adenoviral conjunctivitis, the tear fluids of patients with unilateral acute adenovirus conjunctivitis (UAAC), normal donors (control) and patients with allergic conjunctivitis were analyzed. -
Differentiate Red Eye Disorders
Introduction DIFFERENTIATE RED EYE DISORDERS • Needs immediate treatment • Needs treatment within a few days • Does not require treatment Introduction SUBJECTIVE EYE COMPLAINTS • Decreased vision • Pain • Redness Characterize the complaint through history and exam. Introduction TYPES OF RED EYE DISORDERS • Mechanical trauma • Chemical trauma • Inflammation/infection Introduction ETIOLOGIES OF RED EYE 1. Chemical injury 2. Angle-closure glaucoma 3. Ocular foreign body 4. Corneal abrasion 5. Uveitis 6. Conjunctivitis 7. Ocular surface disease 8. Subconjunctival hemorrhage Evaluation RED EYE: POSSIBLE CAUSES • Trauma • Chemicals • Infection • Allergy • Systemic conditions Evaluation RED EYE: CAUSE AND EFFECT Symptom Cause Itching Allergy Burning Lid disorders, dry eye Foreign body sensation Foreign body, corneal abrasion Localized lid tenderness Hordeolum, chalazion Evaluation RED EYE: CAUSE AND EFFECT (Continued) Symptom Cause Deep, intense pain Corneal abrasions, scleritis, iritis, acute glaucoma, sinusitis, etc. Photophobia Corneal abrasions, iritis, acute glaucoma Halo vision Corneal edema (acute glaucoma, uveitis) Evaluation Equipment needed to evaluate red eye Evaluation Refer red eye with vision loss to ophthalmologist for evaluation Evaluation RED EYE DISORDERS: AN ANATOMIC APPROACH • Face • Adnexa – Orbital area – Lids – Ocular movements • Globe – Conjunctiva, sclera – Anterior chamber (using slit lamp if possible) – Intraocular pressure Disorders of the Ocular Adnexa Disorders of the Ocular Adnexa Hordeolum Disorders of the Ocular -
Evaluation of the Eyebrow Position After External Müller's Muscle
Journal of Plastic, Reconstructive & Aesthetic Surgery (2019) 72, 662–668 Evaluation of the eyebrow position after external Müller’s muscle tucking: A new technique for ptosis repair a , ∗ b c Kenichi Kokubo , Nobutada Katori , Kengo Hayashi , d e f a Jun Sugawara , Seiko Kou , Akiko Fujii , Shoko Haga , f Jiro Maegawa a Department of Plastic Surgery, Fujisawa Shounandai Hospital. 2345 Takakura, Fujisawa-shi, Kanagawa 251-0802, Japan b Department of Ocular Plastic & Orbital Surgery, Seirei Hamamatsu General Hospital. 2-12-12 Sumiyoshi, Naka-ku, Hamamatsu-shi, Shizuoka 430-8558, Japan c Yokohama Sakuragicho Eye Clinic. 1-200 Hinodecho, Naka-ku Yokohama-shi, Kanagawa 231-0006, Japan d JUN CLINIC, 1402-5 Kitaishidocho, Nagano-shi, Nagano 380-0826, Japan e KO CLINIC for Antiaging. 4-54 Onoecho, Naka-ku Yokohama-shi, Kanagawa 231-0015, Japan f Department of Plastic and Reconstructive Surgery, Yokohama City University Hospital. 3-9 Fukuura, Kanazawa-ku, Yokohama-shi, Kanagawa 236-0004, Japan Received 27 August 2018; accepted 6 January 2019 KEYWORDS Summary Eyebrow descent commonly occurs after ptosis repair or blepharoplasty surgery. Müller’s muscle; The procedures used to correct acquired blepharoptosis are primarily classified into four Eyebrow position; groups. These procedures target the levator aponeurosis, Müller’s muscle, both the aponeu- Blepharoptosis; rosis and Müller’s muscle, or the frontalis muscle. In this study, we used a new technique called MRD; external Müller’s muscle tucking (EMMT) on 51 patients (94 eyelids), which targets the Müller’s Ptosis repair muscle for involutional blepharoptosis. The patients were assessed by comparative analysis us- ing pre- and post-operative digital photographs. -
The Distribution of Immune Cells in the Uveal Tract of the Normal Eye
THE DISTRIBUTION OF IMMUNE CELLS IN THE UVEAL TRACT OF THE NORMAL EYE PAUL G. McMENAMIN Perth, Western Australia SUMMARY function of these cells in the normal iris, ciliary body Inflammatory and immune-mediated diseases of the and choroid. The role of such cell types in ocular eye are not purely the consequence of infiltrating inflammation, which will be discussed by other inflammatory cells but may be initiated or propagated authors in this issue, is not the major focus of this by immune cells which are resident or trafficking review; however, a few issues will be briefly through the normal eye. The uveal tract in particular considered where appropriate. is the major site of many such cells, including resident tissue macro phages, dendritic cells and mast cells. This MACRO PHAGES review considers the distribution and location of these and other cells in the iris, ciliary body and choroid in Mononuclear phagocytes arise from bone marrow the normal eye. The uveal tract contains rich networks precursors and after a brief journey in the blood as of both resident macrophages and MHe class 11+ monocytes immigrate into tissues to become macro dendritic cells. The latter appear strategically located to phages. In their mature form they are widely act as sentinels for capturing and sampling blood-borne distributed throughout the body. Macrophages are and intraocular antigens. Large numbers of mast cells professional phagocytes and play a pivotal role as are present in the choroid of most species but are effector cells in cell-mediated immunity and inflam virtually absent from the anterior uvea in many mation.1 In addition, due to their active secretion of a laboratory animals; however, the human iris does range of important biologically active molecules such contain mast cells. -
Ciliary Zonule Sclera (Suspensory Choroid Ligament)
ACTIVITIES Complete Diagrams PNS 18 and 19 Complete PNS 23 Worksheet 3 #1 only Complete PNS 24 Practice Quiz THE SPECIAL SENSES Introduction Vision RECEPTORS Structures designed to respond to stimuli Variable complexity GENERAL PROPERTIES OF RECEPTORS Transducers Receptor potential Generator potential GENERAL PROPERTIES OF RECEPTORS Stimulus causing receptor potentials Generator potential in afferent neuron Nerve impulse SENSATION AND PERCEPTION Stimulatory input Conscious level = perception Awareness = sensation GENERAL PROPERTIES OF RECEPTORS Information conveyed by receptors . Modality . Location . Intensity . Duration ADAPTATION Reduction in rate of impulse transmission when stimulus is prolonged CLASSIFICATION OF RECEPTORS Stimulus Modality . Chemoreceptors . Thermoreceptors . Nociceptors . Mechanoreceptors . Photoreceptors CLASSIFICATION OF RECEPTORS Origin of stimuli . Exteroceptors . Interoceptors . Proprioceptors SPECIAL SENSES Vision Hearing Olfaction Gustation VISION INTRODUCTION 70% of all sensory receptors are in the eye Nearly half of the cerebral cortex is involved in processing visual information Optic nerve is one of body’s largest nerve tracts VISION INTRODUCTION The eye is a photoreceptor organ Refraction Conversion (transduction) of light into AP’s Information is interpreted in cerebral cortex Eyebrow Eyelid Eyelashes Site where conjunctiva merges with cornea Palpebral fissure Lateral commissure Eyelid Medial commissure (a) Surface anatomy of the right eye Figure 15.1a Orbicularis oculi muscle -
Ν Prefit Examination
Cosmetics and the Contact Lens Wearer - What and Why By Diane F. Drake, LDO, ABOM, FCLSA Mission Statement Better Quality of Life Through Better Vision Course Description This presentation discusses cosmetics offered for the male and female contact lens wearers. Obvious and not so obvious cosmetics such as hairsprays, aftershaves, colognes, and soaps will be discussed. Proper handling and hygiene of contact lenses and the various structures of the tear layer and ocular structure will be included. Discover how improper cosmetic use can affect tear layers and the success or lack of success of the contact lens wearer. Introduction ν Tear layers ν Cosmetic usage ν Importance of tear film ν Patient instructions ν Types of cosmetics ν Conclusion - Communication ν Prefit examination Anatomy of the Eye Cornea Eyelids ν Five distinct layers ν Important in health of eye – Epithelium – Help to keep eye moist – Bowman’s layer – Help to distribute tears, oxygen and – Stroma nutrients – Descemets membrane – Protects the eye from light and injury – Endothelium – Lids are elastic ν Lose elasticity with age Tissues of Eyelids Conjunctiva ν Conjunctiva ν Thin mucous membrane, running ν Termed palpebral aperture continuous from lid to corneal limbus – While opened – Not always same size – Palpebral - lids – Bulbar - Globe of eye ν Contain Meibomian glands ν Contain Sebaceous glands ν Muscles of eyelid – Levator Muscle ν Pumps tears away – Orbicularis Oculi Muscle Contact lenses cannot get lost behind the eye Lacrimal Apparatus - Tear Production ν The conjunctival -
Affections of Uvea Affections of Uvea
AFFECTIONS OF UVEA AFFECTIONS OF UVEA Anatomy and physiology: • Uvea is the vascular coat of the eye lying beneath the sclera. • It consists of the uvea and uveal tract. • It consists of 3 parts: Iris, the anterior portion; Ciliary body, the middle part; Choroid, the third and the posterior most part. • All the parts of uvea are intimately associated. Iris • It is spongy having the connective tissue stroma, muscular fibers and abundance of vessels and nerves. • It is lined anteriorly by endothelium and posteriorly by a pigmented epithelium. • Its color is because of amount of melanin pigment. Mostly it is brown or golden yellow. • Iris has two muscles; the sphincter which encircles the pupil and has parasympathetic innervation; the dilator which extends from near the sphincter and has sympathetic innervation. • Iris regulates the amount of light admitted to the interior through pupil. • The iris separates the anterior chamber from the posterior chamber of the eye. Ciliary Body: • It extends backward from the base of the iris to the anterior part of the choroid. • It has ciliary muscle and the ciliary processes (70 to 80 in number) which are covered by ciliary epithelium. Choroid: • It is located between the sclera and the retina. • It extends from the ciliaris retinae to the opening of the optic nerve. • It is composed mainly of blood vessels and the pigmented tissue., The pupil • It is circular and regular opening formed by the iris and is larger in dogs in comparison to man. • It contracts or dilates depending upon the light source, due the sphincter and dilator muscles of the iris, respectively. -
Conjunctival Flora of Normal Human Eye Which Vary with Age, Sex, Geographical Distribution, Right and Left Eye
Central JSM Ophthalmology Research Article *Corresponding author Purnima Rajkarnikar Sthapit, Department of Ophthalmology, Dhulikhel Hospital, Kathmandu Conjunctival Flora of Normal University Hospital, Dhulikhel, Kavre, Nepal, Tel: 009779813254962; Fax: 0097711490707; Email: Human Eye Submitted: 23 February 2014 Purnima Rajkarnikar Sthapit1* and Nhuchhe Ratna Tuladhar2 Accepted: 03 March 2014 1Department of Ophthalmology, Kathmandu University School of Medical Sciences, Nepal Published: 07 March 2014 2Department of Microbiology, Kathmandu University School of Medical Sciences, Nepal ISSN: 2333-6447 Copyright Abstract © 2014 Sthapit et al. Background: The normal flora of the eye plays an important role in maintaining OPEN ACCESS ocular homeostasis by various mechanisms. They comprise of mainly bacteria which do not cause infection in normal conditions but can be a main source of infection after Keywords ocular surgery, trauma or in immune compromised. The ranges of these microorganisms • Coagulase positive Staphylococcus vary with age, sex and geographical distribution. Therefore it is very important for the • Normal flora ophthalmologist to know the ocular normal flora before giving prophylactic antibiotics • Ocular infection and treating infections. • Ocular trauma Objectives: To describe the conjunctival flora of normal human eye which vary with age, sex, geographical distribution, right and left eye. Methodology: A total of 200 conjunctival swabs from 100 patients with healthy eyes were sent for microbiological evaluation to describe the various microorganisms isolated as normal flora of conjunctiva. Result: The growth of bacteria was seen in 78.5% of patients, the commonest flora isolated was Coagulase negative Staphylocccus in 51%. Greater number of male patients had sterile conjunctiva than females and conjunctiva of old people were found to be increasingly more colonised than young. -
Passport to Success
The following terms and other boldface terms in the chapter are defined in the Glossary accommodation choroid After careful study of this chapter, you should be able to: cochlea conjunctiva 1. Describe the function of the sensory system convergence 2. Differentiate between the special and general senses and give examples of each cornea 3. Describe the structure of the eye gustation 4. List and describe the structures that protect the eye lacrimal apparatus 5. Define refraction and list the refractive parts of the eye lens (crystalline lens) 6. Differentiate between the rods and the cones of the eye olfaction 7. Compare the functions of the extrinsic and intrinsic muscles of organ of Corti the eye ossicle 8. Describe the nerve supply to the eye proprioceptor 9. Describe the three divisions of the ear refraction 10. Describe the receptor for hearing and explain how it functions retina 11. Compare static and dynamic equilibrium and describe the sclera location and function of these receptors semicircular canal 12. Explain the function of proprioceptors sensory adaptation 13. List several methods for treatment of pain sensory receptor 14. Describe sensory adaptation and explain its value tympanic membrane 15. Show how word parts are used to build words related to the vestibule sensory system (see Word Anatomy at the end of the chapter) vitreous body PASSport to Success Visit thePoint or see the Student Resource CD in the back of this book for definitions and pronun- ciations of key terms as well as a pretest for this chapter. ® Paul’s Second Case: Seeing More of the Sun’s Effects aul glanced once again at the postcard condition, and it does have a hereditary fac- sitting on his entranceway table as he ar- tor.” The doctor dilated Paul’s eyes with drops Prived home in the evening. -
The Proteomes of the Human Eye, a Highly Compartmentalized Organ
Proteomics 17, 1–2, 2017, 1600340 DOI 10.1002/pmic.201600340 (1 of 3) 1600340 The proteomes of the human eye, a highly compartmentalized organ Gilbert S. Omenn Center for Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA Proteomics has now published a series of Dataset Briefs on the EyeOme from the HUPO Received: November 2, 2016 Human Proteome Project with high-quality analyses of the proteomes of these compartments Accepted: November 4, 2016 of the human eye: retina, iris, ciliary body, retinal pigment epithelium/choroid, retrobulbar optic nerve, and sclera, with 3436, 2929, 2867, 2755, 2711, and 1945 proteins, respectively. These proteomics resources represent a useful starting point for a broad range of research aimed at developing preventive and therapeutic interventions for the various causes of blindness. Keywords: Biomedicine / Biology and Disease-driven Human Proteome Project / End Blindness by 2020 / Eye proteome / EyeOme / Human Proteome Project See accompanying articles in the EyeOme series: http://dx.doi.org/10.1002/pmic.201600229; http://dx.doi.org/10.1002/pmic.201500188; http://dx.doi.org/10.1002/pmic.201400397 Proteomics has now published a series of four papers on compartments of the eye as shown in Fig. 1. As was noted [5], the human eye proteome [1–4]. Under the aegis of the Hu- it was not feasible to assess the quality of the data or estimate man Proteome Organization Biology and Disease-driven Hu- numbers of likely false positives in the heterogeneous studies man Proteome Project (HPP), the EyeOme was organized by from which these findings were summarized.