DOCSLIB.ORG

Methamphetamine Synthesis L ______I ______D ______ Most Commonly Synthesized E Controlled Substance ______3 ______8

Total Page：16

File Type：pdf, Size：1020Kb

Download full-text PDF Read full-text
Methamphetamine Synthesis L ______I ______D ______ Most Commonly Synthesized E Controlled Substance ______3 ______8 S ___________________________________ l Introductions and Welcome ___________________________________ i d ___________________________________ e Course coordinator’s welcome ___________________________________ Instructor introductions 1 Participant introductions ___________________________________ ___________________________________ ___________________________________ S ___________________________________ Administrative Information l ___________________________________ i ___________________________________ Breaks and start times d Restroom location ___________________________________ Eating or smoking in classroom e ___________________________________ ___________________________________ 2 ___________________________________ S ___________________________________ Course Overview & Objectives l ___________________________________ i ___________________________________ Purpose: Train first responders to… d Recognize a clandestine drug lab… ___________________________________ Recognize drug lab paraphernalia… e Implement appropriate actions. ___________________________________ ___________________________________ 3 ___________________________________ S ___________________________________ Drug Lab Definitions l ___________________________________ i ___________________________________ Lab—General Definition d Covert or secret illicit operation ___________________________________ Combination of apparatus & chemicals e Used to make controlled substances. ___________________________________ ___________________________________ 4 ___________________________________ S ___________________________________ Routine Call ? l ___________________________________ i Emergency response ___________________________________ personnel must d recognize and ___________________________________ understand the e potential hazards to ___________________________________ themselves and to the public whenever they ___________________________________ become aware of the possible presence of an 5 illicit drug lab. ___________________________________ S ___________________________________ Meth Lab Locations l ___________________________________ i Houses Wooded Areas ___________________________________ d Apartments Rental Storage ___________________________________ Motels Industrial Areas e Vehicles RVs ___________________________________ ___________________________________ 6 ___________________________________ S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 7 ___________________________________ S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 8 ___________________________________ S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 9 ___________________________________ S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 1 ___________________________________ 0 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 1 ___________________________________ 1 S ___________________________________ Drug Lab Locations l ___________________________________ i ___________________________________ Other d Tunnels, mine shafts and other ___________________________________ subterranean areas e Remote disposal sites ___________________________________ ___________________________________ 1 ___________________________________ 2 S ___________________________________ Drug Lab Definitions l ___________________________________ i ___________________________________ Waste/Abandonment/Disposal Site d Location at which… ___________________________________ Apparatus, equipment & chemicals used to… e Make controlled substances… ___________________________________ Have been deposited, disposed of, ___________________________________ dumped or stored 1 ___________________________________ 3 S ___________________________________ Waste/Abandonment/Disposal l Site ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 1 ___________________________________ 4 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 1 ___________________________________ 5 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 1 ___________________________________ 6 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 1 ___________________________________ 7 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 1 ___________________________________ 8 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 1 ___________________________________ 9 S ___________________________________ Physical Hazards l ___________________________________ i ___________________________________ Dangerous suspects. d Armed or ___________________________________ Under influence of illicit drugs e ___________________________________ ___________________________________ 2 ___________________________________ 0 S ___________________________________ Physical Hazards l ___________________________________ i ___________________________________ Defensive systems d Explosive devices ___________________________________ Mechanical & electrical security devices e Alarm systems ___________________________________ Animals ___________________________________ 2 ___________________________________ 1 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 2 ___________________________________ 2 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 2 ___________________________________ 3 S ___________________________________ Chemical Hazards l ___________________________________ i ___________________________________ Unidentified chemicals d Flammable/combustible ___________________________________ Reactive e Corrosive ___________________________________ Toxic ___________________________________ Any/all DOT Hazard Classes 2 ___________________________________ 4 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 2 ___________________________________ 5 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 2 ___________________________________ 6 S ___________________________________ Chemical Hazards l ___________________________________ i ___________________________________ Unsafe practices and d Improvised/incompatible lab equip ___________________________________ e ___________________________________ ___________________________________ 2 ___________________________________ 7 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 2 ___________________________________ 8 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 2 ___________________________________ 9 S ___________________________________ l ___________________________________ i ___________________________________ d ___________________________________ e ___________________________________ ___________________________________ 3 ___________________________________ 0 S ___________________________________ Chemical Hazards l ___________________________________
Load more

Recommended publications
  • Novel Neuroprotective Compunds for Use in Parkinson's Disease
    Novel neuroprotective compounds for use in Parkinson’s disease A thesis submitted to Kent State University in partial Fulfillment of the requirements for the Degree of Master of Science By Ahmed Shubbar December, 2013 Thesis written by Ahmed Shubbar B.S., University of Kufa, 2009 M.S., Kent State University, 2013 Approved by ______________________Werner Geldenhuys ____, Chair, Master’s Thesis Committee __________________________,Altaf Darvesh Member, Master’s Thesis Committee __________________________,Richard Carroll Member, Master’s Thesis Committee ___Eric_______________________ Mintz , Director, School of Biomedical Sciences ___Janis_______________________ Crowther , Dean, College of Arts and Sciences ii Table of Contents List of figures…………………………………………………………………………………..v List of tables……………………………………………………………………………………vi Acknowledgments.…………………………………………………………………………….vii Chapter 1: Introduction ..................................................................................... 1 1.1 Parkinson’s disease .............................................................................................. 1 1.2 Monoamine Oxidases ........................................................................................... 3 1.3 Monoamine Oxidase-B structure ........................................................................... 8 1.4 Structural differences between MAO-B and MAO-A .............................................13 1.5 Mechanism of oxidative deamination catalyzed by Monoamine Oxidases ............15 1 .6 Neuroprotective effects
    [Show full text]
  • Review Paper Monoamine Oxidase Inhibitors: a Review Concerning Dietary Tyramine and Drug Interactions
    PsychoTropical Commentaries (2016) 1:1 – 90 © Fernwell Publications Review Paper Monoamine Oxidase Inhibitors: a Review Concerning Dietary Tyramine and Drug Interactions PK Gillman PsychoTropical Research, Bucasia, Queensland, Australia Abstract This comprehensive monograph surveys original data on the subject of both dietary tyramine and drug interactions relevant to Monoamine Oxidase Inhibitors (MAOIs), about which there is much outdated, incorrect and incomplete information in the medical literature and elsewhere. Fewer foods than previously supposed have problematically high tyramine levels because international food hygiene regulations have improved both production and handling. Cheese is the only food that has, in the past, been associated with documented fatalities from hypertension, and now almost all ‘supermarket’ cheeses are perfectly safe in healthy-sized portions. The variability of sensitivity to tyramine between individuals, and the sometimes unpredictable amount of tyramine content in foods, means a little knowledge and care are still advised. The interactions between MAOIs and other drugs are now well understood, are quite straightforward, and are briefly summarized here (by a recognised expert). MAOIs have no apparently clinically relevant pharmaco-kinetic interactions, and the only significant pharmaco-dynamic interaction, other than the ‘cheese reaction’ (caused by indirect sympatho-mimetic activity [ISA], is serotonin toxicity ST (aka serotonin syndrome) which is now well defined and straightforward to avoid by not co-administering any drug with serotonin re-uptake inhibitor (SRI) potency. There are no therapeutically used drugs, other than SRIs, that are capable of inducing serious ST with MAOIs. Anaesthesia is not contra- indicated if a patient is taking MAOIs. Most of the previously held concerns about MAOIs turn out to be mythical: they are either incorrect, or over-rated in importance, or stem from apprehensions born out of insufficient knowledge.
    [Show full text]
  • Controlled Substances in Mexico • Fraction I
    INTER-AMERICAN DRUG ABUSE CONTROL COMMISSION C I C A D SIXTY-SECOND REGULAR SESSION OEA/Ser.L/XIV.2.62 December 13 - 15 , 2017 CICAD/doc.2343/17 Washington, D.C. 12 December 2017 Original: Español NEW TRENDS AND EMERGING CHALLENGES IN THE INTERNATIONAL CONTROL OF CHEMICAL PRECURSORS, SYNTHETIC DRUGS AND NEW PSYCHOACTIVE SUBSTANCES CRIMINAL INVESTIGATION AGENCY “SCIENCE AT THE SERVICE OF JUSTICE” New trends and emerging challenges in the international control of chemical precursors, synthetic drugs and new psychoactive substances 62 Regular Session of CICAD Washington D.C. December 13-15, 2017 Background Amphetamine-type stimulants have positioned themselves as one of the main drugs of consumption in the world. To maintain the supply of consumer demand, the production and trafficking of methamphetamine has evolved, always seeking to evade the regulation implemented by the authorities to contain the proliferation of drugs. Source: United Nations Office against Drugs and Crime, World Report on Drugs 2017 Legal framework International: United Nations Convention on Convention against Psychotropic Illicit Traffic in 1961 Substances Narcotic Drugs and Psychotropic Substances Single Convention on Narcotic Drugs 1961. 1971 1988 Amended by the 1972 Protocol. Legal framework International: Precursors and chemical substances frecuently used in the illicit manufacture of narcotic drugs and psychotropic substances I II 1. N-acetylanthranilic acid 1. Acetone 2. Phenylacetic acid 2. Anthranilic acid 3. Acetic anhydride 3. Hydrochloric acid 4. Acetic anhydride 4. Sulphuric acid 5. Ephedrine 5. Ethyl ether 1988 6. Ergometrine 6. Methylethylketone 7. Ergotamine 7. Piperidine 8. Alpha-phenylacetoacetonitrile 8. Toluene 9. 1-Phenyl-2-Propanone 10. Isosafrole 11.
    [Show full text]
  • United States Patent 15) 3,669,956 Borck Et Al
    United States Patent 15) 3,669,956 Borck et al. (45) June 13, 1972 54) 4-SUBSTITUTEDAMNO 260/472, 260/516, 260/518 R, 260/518 A, 260/519, PHENYACETIC ACDS AND 260/556 AR, 260/556 B, 260/558 S, 260/558 A, DERVATIVES THEREOF 260/559 T, 260/559 A, 260/.571, 260/574, 260/.575, (72 Inventors: Joachim Borck; Johann Dahin; Volker 424/244, 424/246, 424/248, 424/250, 424/267, Koppe; Josef Kramer; Gustav Shorre; J. 424/270, 424/272, 424/273, 424/274, 424/304, W. Hermann Hovy; Ernst Schorscher, all 424/309, 424/32 i, 424/324, 424/330 of Darmstadt, Germany 51) int. Cl. ........................................................ C07d 41/04 58) Field of Search........ 260/294X,293.4, 293.47, 239 BF, 73) Assignee: E. Merck A. G., Darmstadt, Germany 260/326.3, 294.3 E (22) Filed: July 22, 1968 56) References Cited (21) Appl. No.: 746,326 UNITED STATES PATENTS (30) Foreign Application Priority Data 3,252,970 5/1966 Huebner................................ 260/239 July 22, 1967 Germany.............................. M 74881 3,385,852 5/1968 Casadio................................. 260/246 Jan. 8, 1968 Germany... ....M 76850 OTHER PUBLICATIONS Feb. 23, 1968 Germany...... ...M 77363 March 1, 1968 Germany.............................. M 77429 Norman et al., J. Chen. Soc. 1963, (Nov.), 5431-6. (52) U.S. Cl................... 260/239 BF, 260/239 A, 260/239 E, Primary Examiner-Henry R. Jiles 260/243 B, 260/246, 260/247. 1, 260/247.2 R, Assistant Examiner-G. Thomas Todd 260/247.2 A, 260/247.2 B, 260/247.5 R, 260/247.7 Attorney-Millen, Raptes & White A, 260/247.7 H,
    [Show full text]
  • Capacitive Sensing of N-Formylamphetamine Based on Immobilized Molecular Imprinted Polymers
    Biosensors and Bioelectronics 92 (2017) 741–747 Contents lists available at ScienceDirect Biosensors and Bioelectronics journal homepage: www.elsevier.com/locate/bios Capacitive sensing of N-formylamphetamine based on immobilized MARK molecular imprinted polymers Kinga Graniczkowskaa, Michael Pützb, Frank M. Hauserb, Sarah De Saegera, ⁎ Natalia V. Beloglazovaa, a Faculty of Pharmaceutical Sciences, Department of Bioanalysis, Laboratory of Food Analysis, Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium b Bundeskriminalamt, Forensic Science Institute, KT45 – Toxicology, 65173 Wiesbaden, Germany ARTICLE INFO ABSTRACT Keywords: A highly sensitive, capacitive biosensor was developed to monitor trace amounts of an amphetamine Capacitive biosensor precursor in aqueous samples. The sensing element is a gold electrode with molecular imprinted polymers Molecular imprinted polymers (MIPs) immobilized on its surface. A continuous-flow system with timed injections was used to simulate flowing N-formyl amphetamine waterways, such as sewers, springs, rivers, etc., ensuring wide applicability of the developed product. MIPs, Water analysis implemented as a recognition element due to their stability under harsh environmental conditions, were synthesized using thermo- and UV-initiated polymerization techniques. The obtained particles were compared against commercially available MIPs according to specificity and selectivity metrics; commercial MIPs were characterized by quite broad cross-reactivity to other structurally related amphetamine-type stimulants. After the best batch of MIPs was chosen, different strategies for immobilizing them on the gold electrode’s surface were evaluated, and their stability was also verified. The complete, developed system was validated through analysis of spiked samples. The limit of detection (LOD) for N-formyl amphetamine was determined to be 10 μM in this capacitive biosensor system.
    [Show full text]
  • Recent Trends in the Quantification of Biogenic Amines in Biofluids
    Journal of Clinical Medicine Review Recent Trends in the Quantification of Biogenic Amines in Biofluids as Biomarkers of Various Disorders: A Review Alina Plenis 1,* , Ilona Ol˛edzka 1 , Piotr Kowalski 1 , Natalia Mi˛ekus 1,2 and Tomasz B ˛aczek 1 1 Department of Pharmaceutical Chemistry, Medical University of Gda´nsk,Hallera 107, 80-416 Gda´nsk, Poland; [email protected] (I.O.); [email protected] (P.K.); [email protected] (N.M.); [email protected] (T.B.) 2 Department of Animal and Human Physiology, Faculty of Biology, University of Gda´nsk,Wita Stwosza 59, 80-308 Gda´nsk,Poland * Correspondence: [email protected]; Fax: +48-58-349-16-35 Received: 4 April 2019; Accepted: 6 May 2019; Published: 9 May 2019 Abstract: Biogenic amines (BAs) are bioactive endogenous compounds which play a significant physiological role in many cell processes like cell proliferation and differentiation, signal transduction and membrane stability. Likewise, they are important in the regulation of body temperature, the increase/decrease of blood pressure or intake of nutrition, as well as in the synthesis of nucleic acids and proteins, hormones and alkaloids. Additionally, it was confirmed that these compounds can be considered as useful biomarkers for the diagnosis, therapy and prognosis of several neuroendocrine and cardiovascular disorders, including neuroendocrine tumours (NET), schizophrenia and Parkinson’s Disease. Due to the fact that BAs are chemically unstable, light-sensitive and possess a high tendency for spontaneous oxidation and decomposition at high pH values, their determination is a real challenge. Moreover, their concentrations in biological matrices are extremely low.
    [Show full text]
  • Gut-Brain Axis Cross-Talk and Limbic Disorders As Biological Basis of Secondary TMAU
    Journal of Personalized Medicine Article Gut-Brain Axis Cross-Talk and Limbic Disorders as Biological Basis of Secondary TMAU Luigi Donato 1,2 , Simona Alibrandi 1,3, Concetta Scimone 1,2,* , Andrea Castagnetti 4, Giacomo Rao 5, Antonina Sidoti 1 and Rosalia D’Angelo 1 1 Department of Biomedical and Dental Sciences and Morphofunctional Imaging, Division of Medical Biotechnologies and Preventive Medicine, University of Messina, 98125 Messina, Italy; [email protected] (L.D.); [email protected] (S.A.); [email protected] (A.S.); [email protected] (R.D.) 2 Department of Biomolecular Strategies, Genetics and Avant-Garde Therapies, I.E.ME.S.T., 90139 Palermo, Italy 3 Department of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, 98125 Messina, Italy 4 Wellmicro Start Up, Innovative Spin-Off Alma Mater Studiorum Università di Bologna, 40129 Bologna, Italy; [email protected] 5 Central Health Superintendence, Prevention and Research Division, INAIL, 00144 Rome, Italy; [email protected] * Correspondence: [email protected]; Tel.: +39-0902213136 Abstract: Background: Trimethylaminuria (TMAU) is a rare metabolic syndrome characterized by the accumulation and the excretion of trimethylamine (TMA), a volatile diet compound produced by gut microbiota. Gut microbiota alterations are mainly involved in the secondary TMAU, whose patients show also different psychiatric conditions. We hypothesized that the biological activity of several molecules acting as intermediate in TMA metabolic reaction might be at the basis of TMAU psychiatric comorbidities. Methods: To corroborate this hypothesis, we performed the analysis Citation: Donato, L.; Alibrandi, S.; of microbiota of both psychiatric suffering secondary TMAU patients and TMAU “mentally ill” Scimone, C.; Castagnetti, A.; Rao, G.; controls, comparing the alteration of metabolites produced by their gut bacteria possibly involved Sidoti, A.; D’Angelo, R.
    [Show full text]
  • What Foods Are Rich in Dietary TMAO Precursors?
    What is TMAO? TMAO (or trimethylamine N-oxide) is a metabolite produced by gut bacteria. Briefly, nutrients such as phosphatidylcholine (also known as lecithin), choline, and L-carnitine are abundant in animal-derived products such as red meat, egg yolk and full-fat dairy products. When consumed, these nutrients are processed by gut bacteria resulting in the release of various metabolites including TMA (trimethylamine) into the blood. TMA is then transported to the liver where it is converted into TMAO which has been shown to regulate various physiological processes involved in the development of atherosclerosis1,2. What foods are rich in dietary TMAO precursors? Red Meat Full-Fat Dairy Products Others Beef Whole milk Energy drinks Pork Eggs Dietary supplements Ham Yogurt Lamb Cream cheese Veal Butter Processed meats What dietary modification may help reduce an elevated TMAO? The composition of the diet can have a dramatic effect on the composition of the gut microbiome. Through dietary modifications, including the elimination of TMAO precursors, the gut bacteria may be altered and TMAO levels reduced. Foods commonly found in the Mediterranean diet such as cold-pressed olive oil, balsamic vinegar, and red wine are rich in the compound DMB (or 3,3-dimethyl-1-butanol), which has been shown to inhibit TMAO production3. My patient is taking a fish oil/krill oil supplement, will it falsely elevate their TMAO results? To date, we know that TMAO is found in high levels in certain types of seafood. A comprehensive list of the contents in supplements are rarely listed, so it is possible that TMAO may be present in fish oil/krill oil supplements.
    [Show full text]
  • Sulfur Trioxide Trimethylamine Complex
    Sulfur trioxide trimethylamine complex sc-229350 Material Safety Data Sheet Hazard Alert Code Key: EXTREME HIGH MODERATE LOW Section 1 - CHEMICAL PRODUCT AND COMPANY IDENTIFICATION PRODUCT NAME Sulfur trioxide trimethylamine complex STATEMENT OF HAZARDOUS NATURE CONSIDERED A HAZARDOUS SUBSTANCE ACCORDING TO OSHA 29 CFR 1910.1200. NFPA FLAMMABILITY1 HEALTH4 HAZARD INSTABILITY2 W SUPPLIER Santa Cruz Biotechnology, Inc. 2145 Delaware Avenue Santa Cruz, California 95060 800.457.3801 or 831.457.3800 EMERGENCY: ChemWatch Within the US & Canada: 877-715-9305 Outside the US & Canada: +800 2436 2255 (1-800-CHEMCALL) or call +613 9573 3112 SYNONYMS C3-H9-N-O3-S, (CH3)3N.SO3 Section 2 - HAZARDS IDENTIFICATION CHEMWATCH HAZARD RATINGS Min Max Flammability: 1 Toxicity: 4 Body Contact: 4 Min/Nil=0 Low=1 Reactivity: 2 Moderate=2 High=3 Chronic: 3 Extreme=4 CANADIAN WHMIS SYMBOLS 1 of 12 EMERGENCY OVERVIEW RISK Harmful if swallowed. Causes severe burns. Risk of serious damage to eyes. POTENTIAL HEALTH EFFECTS ACUTE HEALTH EFFECTS SWALLOWED ! The material can produce severe chemical burns within the oral cavity and gastrointestinal tract following ingestion. ! Accidental ingestion of the material may be harmful; animal experiments indicate that ingestion of less than 150 gram may be fatal or may produce serious damage to the health of the individual. ! Ingestion of acidic corrosives may produce burns around and in the mouth. the throat and esophagus. <\p>. EYE ! The material can produce severe chemical burns to the eye following direct contact. Vapors or mists may be extremely irritating. ! If applied to the eyes, this material causes severe eye damage.
    [Show full text]
  • Combinatorial Effects of Odorants on Mouse Behavior PNAS PLUS
    Combinatorial effects of odorants on mouse behavior PNAS PLUS Luis R. Saraivaa,1, Kunio Kondoha, Xiaolan Yea, Kyoung-hye Yoona,2, Marcus Hernandeza,3, and Linda B. Bucka,4 aHoward Hughes Medical Institute, Basic Sciences Division, Fred Hutchinson Cancer Research Center, Seattle, WA 98109 Contributed by Linda B. Buck, April 14, 2016 (sent for review February 28, 2016; reviewed by Trese Leinders-Zufall and Lisa Stowers) The mechanisms by which odors induce instinctive behaviors are or combination of receptors has a high probability of eliciting a largely unknown. Odor detection in the mouse nose is mediated by specific response. Their similarity among individuals also suggests >1, 000 different odorant receptors (ORs) and trace amine-associated that these responses may be immune to other olfactory inputs. For receptors (TAARs). Odor perceptions are encoded combinatorially by example, whereas changes in the combination of activated ORs can ORs and can be altered by slight changes in the combination of acti- change a perceived odor, predator odor activation of a particular vated receptors. However, the stereotyped nature of instinctive odor receptor may induce instinctive aversive behavior regardless of what responses suggests the involvement of specific receptors and geneti- other receptors are simultaneously activated by other odorants in cally programmed neural circuits relatively immune to extraneous odor the environment. One receptor in the vomeronasal organ has been stimuli and receptor inputs. Here, we report that, contrary to expecta- linked to mating behavior (33). However, the only nasal receptors tion, innate odor-induced behaviors can be context-dependent. First, demonstrated to play a role in innate odor responses thus far are the different ligands for a given TAAR can vary in behavioral effect.
    [Show full text]
  • Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis
    International Journal of Molecular Sciences Article Pattern of TAAR5 Expression in the Human Brain Based on Transcriptome Datasets Analysis Anastasia N. Vaganova 1 , Ramilya Z. Murtazina 1 , Taisiia S. Shemyakova 1 , Andrey D. Prjibelski 1 , Nataliia V. Katolikova 1 and Raul R. Gainetdinov 1,2,* 1 Institute of Translational Biomedicine, St. Petersburg State University, Universitetskaya nab. 7/9, 199034 St. Petersburg, Russia; [email protected] (A.N.V.); [email protected] (R.Z.M.); [email protected] (T.S.S.); [email protected] (A.D.P.); [email protected] (N.V.K.) 2 St. Petersburg University Hospital, St. Petersburg State University, Universitetskaya nab. 7/9, 199034 St. Petersburg, Russia * Correspondence: [email protected] Abstract: Trace amine-associated receptors (TAAR) recognize organic compounds, including primary, secondary, and tertiary amines. The TAAR5 receptor is known to be involved in the olfactory sensing of innate socially relevant odors encoded by volatile amines. However, emerging data point to the involvement of TAAR5 in brain functions, particularly in the emotional behaviors mediated by the limbic system which suggests its potential contribution to the pathogenesis of neuropsychiatric diseases. TAAR5 expression was explored in datasets available in the Gene Expression Omnibus, Allen Brain Atlas, and Human Protein Atlas databases. Transcriptomic data demonstrate ubiquitous low TAAR5 expression in the cortical and limbic brain areas, the amygdala and the hippocampus, Citation: Vaganova, A.N.; the nucleus accumbens, the thalamus, the hypothalamus, the basal ganglia, the cerebellum, the Murtazina, R.Z.; Shemyakova, T.S.; substantia nigra, and the white matter. Altered TAAR5 expression is identified in Down syndrome, Prjibelski, A.D.; Katolikova, N.V.; Gainetdinov, R.R.
    [Show full text]
  • Phenylacetic Acid in Human Body Fluids: High Correlation Between Plasma and Cerebrospinal Fluid Concentration Values
    J Neurol Neurosurg Psychiatry: first published as 10.1136/jnnp.45.4.366 on 1 April 1982. Downloaded from Journal of Neurology, Neurosurgery, and Psychiatry 1982;45:366-368 Short report Phenylacetic acid in human body fluids: high correlation between plasma and cerebrospinal fluid concentration values M SANDLER,* CRJ RUTHVEN,* BL GOODWIN,* A LEES,t GM STERNt From the Bernhard Baron Memorial Research Laboratories and Institute of Obstetrics and Gynaecology, Queen Charlotte's Hospital,* and the Department of Neurology, University College Hospital, Londont SUMMARY In a group of six Parkinsonian patients and 13 "controls" with non-Parkinsonian neurological disease, there was a high correlation between both free and conjugated phenylacetic acid concentrations in plasma and cerebrospinal fluid taken at about the same time. This compound is the major metabolite of phenylethylamine, the production of which may be disturbed in a number of neuropsychiatric illnesses. Thus plasma measurements might be employed clinically to provide an estimate ofcentral changes in phenylethylamine economy. A small but significantly higher proportion Protected by copyright. of conjugated phenylacetic acid was present in the plasma (but not cerebrospinal fluid) of Parkin- sonians compared with controls. Phenylacetic acid is the major metabolite of phenyl- been expected between plasma and cerebrospinal ethylamine, a "trace amine"'l which has become the (CSF) compartments. focus of considerable clinical attention in recent With clinical interest being predominantly centred
    [Show full text]