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Instrument Considerations in the Transfer of Chromatographic Methods, Part II: System Considerations Thomas E Volume 36 Number 11, 785–840 11, Number 36 Volume Volume 36 Number 11 November 2018 www.chromatographyonline.com LCGC NORTH AMERICA INSTRUMENT CONSIDERATIONS IN Understanding The Analytical Toolbox Stationary-Phase THE TRANSFER OF for Biopharmaceutical November 2018 November Selectivity for GC CHROMATOGRAPHIC Characterization METHODS magentablackcyanyellow ES39215_LCGC1118_CV1.pgs 11.05.2018 14:54 UBM Feel good in your method development? Feel Better with Us Trust our analytical products in every stage of your drug product development. 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[email protected] UBM Americas (www.ubmlifesciences.com) is a leading worldwide media com- pany providing integrated marketing solutions for the Fashion, Life Sciences and Dave Esola Powersports industries. UBM Americas serves business professionals and consumers in these industries with its portfolio of 91 events, 67 publications and directories, VP & General Manager 150 electronic publications and Web sites, as well as educational and direct market- UBM Life Sciences Group ing products and services. Market leading brands and a commitment to delivering [email protected] innovative, quality products and services enables UBM Americas to “Connect Our Customers With Theirs.” UBM Americas has approximately 1000 employees and currently operates from multiple offices in North America and Europe. MACHEREY-NAGEL Manufacturer of premium chromatography media Chromatography Find what you are looking for! CHROMABOND® columns with classical and innovative SPE phases Original NUCLEOSIL®, professional NUCLEODUR® and highly efficient NUCLEOSHELL® HPLC columns Robust TLC glass plates, economical aluminum and polyester sheets www.mn-net.com 790 LCGC NORTH AMERICA VOLUME 36 NUMBER 11 NOVEMBER 2018 WWW.CHROMATOGRAPHYONLINE.COM CONTENTS COLUMNS 796 LC TROUBLESHOOTING Mixing and Mixers in Liquid Chromatography—Why, When, and How Much? Part II, Injections Dwight R. Stoll What happens when we inject a sample into the mobile-phase stream? Many Volume 36 Number 11 November 2018 LC practitioners are surprised to learn just how serious the effect of the injected www.chromatographyonline.com sample solvent can be. 802 SAMPLE PREP PERSPECTIVES A Look Back and A Look Forward—An Annual Check-up on the State of Sample Preparation Douglas E. Raynie We assess the state of the field, first looking back at developments presented INSTRUMENT Understanding CONSIDERATIONS IN The Analytical Toolbox at conferences this year, reader questions, and the passing of a pioneer in solid- Stationary-Phase THE TRANSFER OF for Biopharmaceutical Selectivity for GC Characterization CHROMATOGRAPHIC phase extraction. Then, we look to the future of sample preparation. METHODS COVER DESIGN BY 806 GC CONNECTIONS Dan Ward Stationary Phase Selectivity: The Chemistry Behind the Separation Cover image courtesy of Nicholas H. Snow Ioana Davies (Drutu) / Here, we focus on selectivity: its definition, its importance for generating stock.adobe.com separations and resolution; and its role in column polarity. 814 FOCUS ON BIOPHARMACEUTICAL ANALYSIS Analytical Characterization of
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