US 2006O165636A1 (19) United States (12) Patent Application Publication (10) Pub. No.: US 2006/0165636A1 HaSebe et al. (43) Pub. Date: Jul. 27, 2006

(54) HAIR TREATMENT COMPOSITION AND (52) U.S. Cl...... 424/70.14 HAIR COSMETC FOR DAMAGED HAIR

(76) Inventors: Kouhei Hasebe, Gifu (JP); Kikumi (57) ABSTRACT Yamada, Gifu (JP) Correspondence Address: The present invention intends to provide a composition for FRISHAUF, HOLTZ, GOODMAN & CHICK, PC hair treatment containing Y-polyglutamic acid or a salt 220 Fifth Avenue thereof, a hair cosmetic for damaged hair containing Such a 16TH Floor composition, and their uses. The composition for hair treat NEW YORK, NY 10001-7708 (US) ment containing Y-polyglutamic acid or a salt thereof and the hair cosmetic for damaged hair of the present invention have (21) Appl. No.: 10/547,492 excellent improvement effects on the strength and frictional (22) PCT Filed: Mar. 3, 2004 force of hair, so that they can provide tension, elasticity, or the like to damage hair to prevent or alleviate split hair and (86). PCT No.: PCT/PO4/O2606 broken hair as well as improvements in combing and touch. (30) Foreign Application Priority Data Furthermore, they also exert effects of moisture retention inherent to Y-polyglutamic acid or a salt thereof, preventing Mar. 10, 2003 (JP)...... 2003-62688 or improving effects on the generation of dandruff on the basis of such effects, preventing effects on the feeling of Publication Classification Stickiness or creak, and various effectiveness including (51) Int. Cl. appropriate residual tendency to hair in a simultaneous A6 IK 8/64 (2006.01) manner, respectively. Patent Application Publication Jul. 27, 2006 US 2006/O165636 A1 A/6, 7

Purified Water Applied (CONTROL) Y Polyglutamic Acid Solution Applied Non-Decolorized Hair Bundle

1.0 1.2 14 1.6 1.8 2.0 Strength of Hair (gf/1.1 m)

A/6, 2

Purified Water Applied (CONTROL) Y-Polyglutamic Acid Solution Applied

Non-Decolorized Hair Bundle

O 0.2 0.4 O.6 0.8 Average Frictional Coefficient (MIU Value) US 2006/0165636 A1 Jul. 27, 2006

HAIR TREATMENT COMPOSITION AND HAIR facture a product without defects as described above while COSMETC FOR DAMAGED HAIR preventing or alleviating the damage of hair. In the cosmet ics industry, it is strongly expected to develop a single TECHNICAL FIELD component, which will prevent or alleviate the damage of 0001. The present invention relates to a composition for hair without causing other defects. hair treatment, which is characterized by containing Y-poly 0006. On the other hand, polyglutamic acid is one of the glutamic acid or a salt thereof, and to a hair cosmetic for components which have been conventionally used for hair damaged hair, which contains such a composition for hair cosmetic. The polyglutamic acid has, in addition to its treatment. thickening action, Superior moisture retention (see JP-B 04-50286), hairdressing effects (see JP-B 47-46910), BACKGROUND ART inflammation-depressing effects and UV-absorbing effects (see JP-A 01-146815), resistance to oxidation (see JP-A 0002 The protein structure of hair is denaturated by 01-146986), stimulatory effects on the production of pyr various kinds of external factors, including: environmental rolidone carboxylic acid (see JP-A 06-329529), alleviating factors such as UV exposure; physical factors such as heat, effects on the feeling of stiffness and creak (see JP-A friction, and dryness due to brushing, driers, and so on; and 10-298037), improving effects on the feeling of smooth hair chemical factors such as components contained in hair dyes, with a combination of an oxidant, a cationic Surfactant, and permanent agents, and hair-breaching agents, so that hair is polyglutamic acid (see JP-A 2002-80330), depressing damaged such as exfoliation of hair cuticles, decreased effects-on discomfort due to polyhydric alcohol (JP-A 2002 water contents in hair, loss in interaction or binding between 145723), effects to protect hair and improve the feeling of keratin proteins, deletion of protein and other hair constitu Smooth hair with a combination of wax, silicones, and ents of hair, or the like. The damaged state of hair leads to polyglutamic acid (JP-A 2002-193752), and so on. The the generation of split hair and broken hair, an increase in efficacies thereof toward various directions have been con frictional force of the surface of hair, a decrease in tension firmed, so that the polyglutamic acid will be one of the very or elasticity of hair, tangled hair, drying out of hair, less beneficial components with respect of its use for hair. Smoothness of hair, and so on. 0007. In consideration of the aforementioned problems, 0003 For preventing or alleviating the damage of hair, as a result of carrying out further investigation into poly conventionally, in the cosmetic industry, there have been glutamic acid which has been conventionally used as a used silicones, polysaccharides, polypeptides, surfactants, multifunctional thickening agent for hair, the inventors of polyols, amino acids, fats and oils, plant extracts, UV the present invention have found that Y-polyglutamic acid or absorbers, UV-scattering agents, and so on. In late years, in a salt thereof can be used for damaged hair to provide the particular, various useful Substances related to the compo damaged hair with excellent strength while lowering the nents conventionally used in the art have been newly devel frictional force of the hair. oped, such as dextrin derivatives (see, JP-A 07-285834), new silicones (JP-A 08-127519, JP-A 08-59440, and JP-A 0008 Furthermore, the inventors of the present invention 09-59132), and new peptide derivatives (JP-A 11-302300 have found that an improvement in strength of damaged hair and JP-A 2000-86462). can be attained by constructing a composition for hair treatment containing Y-polyglutamic acid or a salt thereof or 0004 Furthermore, for allowing each component to exert a hair cosmetic containing the composition to provide the its efficacy sufficiently in parallel with making up for the hair with tension or elasticity while lowering its frictional intrinsic defects of each component (e.g., creak and stiffness force, thereby allowing improvements in combing and touch generated when applied on hair, and a decrease in feeling of of hair. Furthermore, a moisturizing effect inherent to Smooth hair, Such as a greasy feeling, and a decrease in Y-polyglutamic acid or a salt thereof can prevent or alleviate residual percentage in hair), products have been generally the development of dandruff without causing the feeling of constructed by combining various components, respectively Stickiness or creak. In addition, Y-polyglutamic acid or a salt and thus diverse combinations have been conventionally thereof is a water-soluble polymer. Consequently, the inven designed in the cosmetic industry (see JP-A 06-157247, tors of the present invention have also found that the JP-A 07-53332, JP-A 08-208439, JP-A 10-279436, JP-A characteristic features of Y-polyglutamic acid or a salt 2000-191445, and JP-A 2002-145741). thereof. Such as a moderate residual tendency to hair, which 0005. However, when a single component is used for hair have been conventionally reported, can be sufficiently for example, silicones have excellent hair-coating effects to exerted. alleviate split ends and broken hair while causing a decrease in feeling of Smooth hair. In addition, polyols have excellent DISCLOSURE OF THE INVENTION moisture retention and prevent hair from drying but they 0009. That is, according to claim 1 of the present inven have an extremely lower alleviating effect on the damage of tion, there is provided a composition for hair treatment, hair itself. The UV absorber remarkably protects hair from characterized by containing Y-polyglutamic acid or a salt being damaged by UV rays but shows low residual tendency thereof. to the hair. In other words, the UV absorber exerts excellent efficacy while simultaneously exerting undesired defects 0010. According to claim 2 of the present invention, there such as depletion in prolonged durability of effectiveness. is provided a hair cosmetic for damaged hair, characterized Besides, making up the defects by the combination of the by containing the composition for hair treatment of claim 1. respective components requires a high prescription technol 0011. According to claim 3 of the present invention, there ogy and an accumulation of a large quantity of technological is provided a use of Y-polyglutamic acid or a salt thereof in information in the production. It is still difficult to manu the production of a composition for hair treatment. US 2006/0165636 A1 Jul. 27, 2006

0012. According to claim 4 of the present invention, there tillery effluent media and Soybean extract media, and Syn is provided a method of administering a hair cosmetic thetic or semi-synthetic media composed of respective com containing Y-polyglutamic acid or a salt thereof to a patient ponents with any content concentrations in the media for imparting a strength to damaged hair and lowering a optionally selected from: carbon sources such as glucose, frictional force of the hair. fructose, galactose, Sucrose, maltose, mannose, lactose, glycerol, and starch; inorganic nitrogen Sources such as BRIEF DESCRIPTION OF THE DRAWINGS ammonium Sulfate, ammonium phosphate, and hydrochloric 0013 FIG. 1 is a diagram illustrating the efficacy of acid ammonium; organic nitrogen Sources such as glutamic Y-polyglutamic acid sodium salt corresponding to the acid or a salt thereof, aspartic acid or a salt thereof, strength of damaged hair. glutamine, and asparagine; major inorganic salts containing 0014 FIG. 2 is a diagram illustrating the efficacy of Sodium chloride, magnesium sulfate, monopotassium phos Y-polyglutamic acid sodium salt corresponding to the mean phate, and disodium phosphate; minor inorganic salts con frictional coefficient of damaged hair. taining atoms of iron, copper, Zinc, cobalt, nickel, boron, manganese, molybdenum, tin, selenium, Silicon, arsenic, BEST MODE FOR CARRYING OUT THE Vanadium, chromium, fluorine, and the like; vitamins such INVENTION as biotin, nicotinic acid amide, calcium pantothenate, thia mine, riboflavine, and pyridoxine hydrochloride; organic 0.015 The Y-polyglutamic acid or a salt thereof used in acids such as citric acid, tartaric acid, malic acid, and the present invention is a compound having a chemical glycolic acid; natural extract products such as yeast extracts, structure represented by Formula 1. meat extracts, potato extracts, tomato extracts, and Soybean Formula 1 peptides; and so on. ...~s.HN ~.HN r-soNH2

wherein R is a hydrogen atom or one optionally selected 0019. With regard to the culture conditions of the micro from: alkali metal atoms such as sodium, potassium, and organism in the present invention, temperatures are defined lithium; tertiary amines Such as trimethylamine, triethy within the range of 20 to 37° C. and further adjusted in the lamine, dimethylamine, diethylamine, trimethanolamine, process of microorganism growth and the production of triethanolamine, dimethanolamine, diethanolamine, and Y-polyglutamic acid, and pH is defined within the range of ethanolamine; and quaternary amines Such as tetramethy 5.0 to 8.0 and further adjusted in the process of microor lamine and tetraethylamine, where the atomic species or ganism growth and the production of Y-polyglutamic acid. molecule species of R exist in the molecule may be identical Besides, the duration of culture may be up to the time at to or different from each other, and n in Formula 1 is 400 or which Y-polyglutamic acid is sufficiently produced. more. 0020. An extraction/purification method for Y-poly 0016. The Y-polyglutamic acid or a salt thereof used in glutamic acid or a salt thereof from a culture medium after the present invention has an average molecular weight of at terminating the culture in the present invention may be least 50,000 or more, preferably 100,000 or more, particu optionally selected from known methods including an acid larly preferably 500,000 or more. The upper limit of the precipitation method, a solvent precipitation method, and a average molecular weight is not specifically limited. How membrane purification method. ever, the upper limit may be placed on an average molecular 0021. The form of Y-polyglutamic acid or a salt thereof in weight of 4,000,000, for example. the present invention may be any of those including liquid, 0017. The Y-polyglutamic acid or a salt thereof used in Solid, powder, paste, and gel forms. The most Suitable form the present invention may be produced by a fermentation can be arbitrarily selected to construct the composition for process using a microorganism. The useful microorganisms hair treatment or hair cosmetic for damaged hair. include those belonging to the genus Bacillus having the 0022. The content of Y-polyglutamic acid or a salt thereof ability to produce Y-polyglutamic acid. Of those, for in the composition for hair treatment according to the example, Bacillus subtilis, Bacillus anthracis, Bacillus present invention may vary slightly depending on the type, licheniformis, and Bacillus megaterium are preferable quality, desired degree of action, and so on of the compo because of their enhanced abilities to produce Y-poly sition and is not specifically limited. In general, it is effective glutamic acid. Those microorganisms may be those trusted when the content of Y-polyglutamic acid or a salt thereof is in a depositary institution or the like or may be bacteria or defined within the range of 0.001% by mass or more, the like commercially available in the market. preferably 0.01 to 50.0% by mass in terms of solid content 0018 Culture media, which can be used for the produc in the total amount of the preparation. In addition, the dosage tion of Y-polyglutamic acid in the fermentation process using form of the composition for hair treatment according to the the microorganism mentioned above, may include natural present invention is arbitrary, and examples thereof include media composed of natural products, such as shochu-dis ample, capsule, powder, granule, pill, tablet, Solid, liquid, US 2006/0165636 A1 Jul. 27, 2006

gel, foam, emulsion, cream, ointment, sheet, moose, pow like), carnauba wax, spermaceti wax, lanolin, liquid lanolin, der-dispersed, multiple-layered, and aerosol forms. reduced lanolin, hard lanolin, candellila wax, montan wax, 0023. It is effective when the content of the composition shellac wax, wax, and rice wax: mineral oils such as liquid for hair treatment with respect to the hair cosmetic for paraffin, paraffin wax, Solid paraffin, Vaseline, paraffin, oZo damaged hair in the present invention, which may vary kerite, ceresin, and microcrystalline wax; natural fatty acids slightly depending on the type, quality, desired degree of Such as lauric acid, myristic acid, palmitic acid, Stearic acid, action, and so on of the hair cosmetic and is not specifically behenic acid, oleic acid, linoleic acid, linolenic acid, docosa limited, is defined within the concentration range of 0.01% hexaenoic acid, eicosapentaenoic acid, 12-hydroxy Stearate, by mass or more, preferably 0.1 to 20.0% by mass in the undecylenic acid, tall oil, and lanolin fatty acid; and fatty total amount of the preparation. acids of synthetic fatty acids such as isononanoic acid, 0024. The hair cosmetic for damaged hair of the present caproic acid, 2-ethylbutanoic acid, isopentanoic acid, 2-me invention may find use in the field of any of cosmetics, thylpentanoic acid, 2-ethylhexanoic acid, isopentanoic acid, quasi-drugs, and pharmaceutical preparations as far as it can and isostearic acid. be applied on hair, and the applications include, but not specifically limited to: cosmetics for washing hair, Such as 0028. Examples of the compound further include poly shampoo, rinse agents, and treatment agents; hair-styling ethylene glycol, polypropylene glycol, gum arabic, gum cosmetics such as hair cream, hair spray, hair tonic, hair gel. benzoin, dammar gum, guaiac resin, Irish moss, karayagum, hair lotion, hair oil, hair essence, hair water, hair wax, and tragacanth gum, carob gum, quince seed, agar, casein, hair foam; hair-restoration and growth agents; hair-coloring dextrin, gelatin, pectin, starch, carageenan, carboxymethyl related products such as hair-coloring pre-treatment agents, chitin or chitosan, hydroxyethyl chitosan, or hydroxyalkyl post-treatment agents, and intermediate-treatment agents; (C2 to C4) chitin or chitosan in which alkylene (C2 to C4) and permanent agent-related products such as permanent oxide such as ethylene oxide is added, low molecular chitin pre-treatment agents, post-treatment agents, and intermedi or chitosan, a chitosan salt, Sulfated chitin or chitosan, ate-treatment agents. In addition, examples of the dosage phospholylated chitin or chitosan, alginic acid or a salt form of the hair cosmetic include, but not specifically thereof, hyaluronic acid or a salt thereof, chondroitin sulfate limited to, Solid, paste, moose, gel, powder, solution, Solu or a salt thereof (such as a Sodium chondroitin Sulfate salt), bilized, emulsified, powder-dispersed, multiple-layered, and heparin, ethylcellulose, methylcellulose, carboxymethylcel aerosol forms. lulose, carboxyethylcellulose, sodium carboxyethylcellu 0025. In the present invention, in addition to Y-poly lose, hydroxyethylcellulose, hydroxypropylcellulose, nitro glutamic acid or a salt thereof which is an essential ingre cellulose, crystalline cellulose, dient for the composition for hair treatment and hair cos hydroxypropylmethylcellulose, polyvinyl alcohol, polyvinyl metic for damaged hair, the composition for hair treatment methyl ether, polyvinylpyrrolidone, vinylpyrrolidone/N.N- and the hair cosmetic for damaged hair may arbitrarily select dimethylaminoethyl methacrylate copolymer diethylsulfate and use together with, as an additive, a film former, a Solution, polyvinyl methacrylate, a polyacrylic acid salt bioactive ingredient, and a preparation-regulating ingredi (such as an octylamide acrylate? acrylhydroxypropyl/buty ents such as a coloring agent, a Surfactant, a fragrance and laminoethyl methacrylate copolymer or an alkanolamine a vehicle, and so on. Thus, the Superior composition for hair acrylic resin), polyalkyleneoxide Such as polyethyleneoxide treatment and the hair cosmetic for damaged hair having or polypropyleneoxide or a crosslinked polymer thereof more various functionalities can be constructed. The content (such as a methylsiloxane/polyoxyethylene copolymer), a of those ingredients in the preparation is generally within the carboxyvinyl polymer, an alkyl denaturated carboxyvinyl concentration range of 0.0001 to 50% by mass. polymer, polyethyleneimine, dermatan Sulfate, keratan Sul 0026. The following component or additive may be fate, glycerin fatty acid pyrrolidone carboxylates, glycerin added in advance or during a manufacturing process of the fatty acid acetyl amino acid esters, pyrrolidone carboxylate composition for hair treatment and hair cosmetic for dam or a salt thereof (Such as sodium pyrrolidone carboxylate), aged hair of the present invention, and whether it is added polyaspartic acid or a salt thereof, polylysine of a salt in advance or during the production process may be chosen thereof, and a water-soluble high molecular polymer Such as appropriately in consideration of workability. a 2-methacryloyloxyehtyl phosphorylcholine copolymer. 0027 Generally, the film-forming agent of the present 0029. Examples of the compound further include silicone invention can be optionally selected from compounds hav compounds Such as a polyether denaturated silicone (such as ing property to form a film over a hair. Examples of the a polyoxyethylene/methylpolysiloxane copolymer or poly compound include: fats and oils such as avocado oil, almond (oxyethylene/oxypropylene) methylpolysiloxane copoly oil, fennel oil, perilla oil, olive oil, orange oil, orange raffer oil, sesame oil, cacao butter, camomile oil, carrot oil, cucum mer), oxazoline denaturated organopolysiloxane, alkyl ber oil, tallowate, Kukui nut oil, safflower oil, silicone oil, denaturated organopolysiloxane, a styrylketone silicone shea butter, liquid shea butter, soybean oil, camelia oil, derivative, dimethylpolysiloxane, methylphenylpolysilox maize oil, rapeseed oil, persic oil, castor oil (polyoxyethyl ane, epoxy denaturated silicone, fluorine denaturated sili ene (POE) hardened castor oil, derivatives thereof (40, 50. cone, alcohol denaturated silicone, alkyl denaturated silicon, and 60 EO), and the like), jojoba oil, cottonseed oil, peanut alkoxy denaturated silicone, amino denaturated silicone, oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel ammonium denaturated polymeric silicone, organopolysi oil, haze wax, coconut oil, beef tallow, lard, squalene, loxane, methylphenylpolysiloxane, polysiloxane, poly squalane, pristane, and hydrogenated products thereof (hard (N-acylalkyleneimine)denaturated silicone, dimethylpolysi ened oils); waxes such as beeswax (white beeswax or the loxane, methylphenylpolysiloxane, a nitrogen-containing US 2006/0165636 A1 Jul. 27, 2006 acryl-silicone-based graft copolymer, decamethyl cyclopen diethanolamine phosphate salt, a 6-O-alkylascorbic acid tri tanesiloxane, fluorine Substituted alkyl denaturated silicone, ethanolamine phosphate salt, a 6-O-alkylascorbic acid organopolysiloxanyl silylalkyl denaturated silicone, tricy monoisopropanolamine phosphate salt, a 6-O-alkylascorbic clic diterpene carboxylate denaturated silicone, trifluoro acid diisopropanolamine phosphate salt, a 6-O-alkylascorbic alkyl denaturated silicone, polydimethylsiloxane, divi acid triisopropanolamine phosphate salt, 3-O-glycosyl-L- nylpolydimethylsiloxane, ascorbic acid, a 6-o-B-Dgalactopyranosyl-L-ascorbic acid, dihydrogenopolydimethylsiloxane, a dihydrogenopolydim cholesterol phosphated ascorbic acid, L-ascorbyl palmitate, ethylsiloxane divinylpolydimethylsiloxane polymer, trim L-ascorbyl isopalmitate, L-ascorbyl dipalmitate, L-ascorbyl ethylsiloxysilicic acid, a polyoxypropylene/methylpolysi diisopalmitate, L-ascorbyl Stearate, L-ascorbyl isostearate, loxane copolymer, ethylpolysiloxane, L-ascorbyl distearate, L-ascorbyl diisoStearate, L-ascorbyl ethylmethylpolysiloxane, ethylphenylpolysiloxane, octam myristate, L-ascorbyl isomyristate, L-ascorbyl dimyristate, ethylcyclotetrasiloxane, diorganopolysiloxane, octamethyl L-ascorbyl diisomyristate, L-ascorbyl 2-ethylhexanoate, cyclotetrasiloxane, tetramethyl tetraphenyl tetracyclosilox L-ascorbyl di-2-ethylhexanoate, oleate-L-ascorbic acid, 2-o- ane, polyether denaturated polysiloxane, amino denaturated C-D-glucosyl-L-ascorbic acid, 2-O-O-D-maltosyl-L-ascor polysiloxane, epoxy denaturated polysiloxane, fluorine bic acid, 2-o-C-D-maltotriosyl-L-ascorbic acid, 3-O-O-D- denaturated polysiloxane, alcohol denaturated polysiloxane, glucosyl-L-ascorbic acid, 3-O-O-D-maltosyl-L-ascorbic alkyl denaturated polysiloxane, dodecamethyl cyclohexasi acid, 2-o-C-D-maltotriosyl-L-ascorbic acid, tetraisopalmi loxane, laurylmethicone copolyol, an aminoethylaminopro tate L-ascobic acid, tetralaurate L-ascobic acid, tetra-2- pylsiloxane/dimethylsiloxane copolymer, and eugenol dena ethylhexanoate L-ascobic acid, tetraoleate L-ascobic acid, turated silicone. 5.6-isopropylidene-L-ascorbic acid, retinoate L-ascobic acid, L-ascorbic acid-DL-tocopherol phosphate, L-3-O-ethy 0030 Generally, a bioactive ingredient to be used in the lascorbic acid, L-ascorbic acid tristearate, L-ascorbic acid present invention can be optionally selected from com tripalmitate, L-ascorbic acid trioleate, L-ascorbic acid triph pounds having any useful bioactivity to a hair. Examples osphate, 2-O-ascorbyl cinnamate, 2-O-ascorbyl ferulate, 2-o- thereof include a p-aminobenzoic acid derivative, a salicylic ascorbyl caffeate, 2-O-ascorbyl cinnapate, 2-o-6-palmitoy acid derivative, a benzenesulfonamide derivative, a imida lascorbyl-4'-acetoxyferulate, DL-C.-tocopherol-2-L- Zole derivative, a naphthalene derivative, hydroxyanthra ascorbic acid phosphodiester, an ascorbic acid inositol nilic acid or a salt thereof or a derivative thereof, a anthra binding derivative, a phosphoamide ascorbate derivative, an nilic acid derivative, a coumarin derivative, an amino acid derivative (2-amino-3-1-carboxyl-2-(1H-imidazol-4-yl)e- ascorbic acid arbutin conjugate, ascorbylphosphoryl cho htylaminobutanoic acid, 2-amino-3-1-carboxyl-2-(1H lestelol, a chromanil ascorbic acid derivative, an ascorbic imidazol-4-yl)ethylaminobutanoic acid hydrochloride, acid cyalate derivative, or the like). 2-amino-3-1-carboxyl-2-(1H-imidazol-4-yl)ehtylami 0031 Examples of the compound further include: toco nobutanoic acid sodium salt, or 2-amino-3-1-carboxyl-2- pherol, a salt thereof, and a derivative thereof (such as (1H-imidazol-4-yl)ethylaminobutanoic acid potassium C-tocopherol, B-tocopherol, Y-tocopherol, 8-tocopherol, salt), a benzotriazole derivative, a tetrazole derivative, an e-tocopherol, C-tocopherylretinoate, aminomethylated toco imidazoiline derivative, a pyrimidine derivative, a dioxane pherol, hydroxymethylated tocopherol, tocopheryl phos derivative, a camphor derivative, a furan derivative, a phate, tocopherolacetate, tocopherolinicotinate, tocopherol pyrone derivative, a nucleic acid derivative, an allantoin Succinate, tocopherollinoleate, tocopherolorotate DL-C.- derivative, a nicotinic acid derivative, and ascorbic acid or tocopherylglucoside, DL-C.-tocopherylmaltoside, DL-B- a salt thereof or a derivative thereof (phosphoric acid-L- tocopherylglucoside, DL-B-tocopherylmaltoside, DL-y- magnesium ascorbate, ascorbyl palmitate, ascorbyl dipalmi tocopherylglucoside, DL-y-tocopherylmaltoside, DL-8- tate, glucosyl ascorbic acid, hydroxyproline phosphate tocopherylglucoside, DL-8-tocopherylmaltoside, D-O- ascorbic acid, 5-O-O-D-glucopyranosyl-L-ascorbic acid, tocopherylglucoside, D-O-tocopherylmaltoside, D-B- L-phosphate ascorbic acid sodium salt, L-phosphate ascor tocopherylglucoside, D-B-tocopherylmaltoside, D-y- bic acid potassium salt, L-phosphate ascorbic acid magne tocopherylglucoside, D-y-tocopherylmaltoside, D-8- sium salt, L-phosphate ascorbic acid calcium salt, L-phos tocopherylglucoside, D-8-tocopherylmaltoside, L-O- phate ascorbic acid aluminum salt, L-sulfate ascorbic acid tocopherylglucoside, L-C-tocopherylmaltoside, L-B- Sodium salt, L-sulfate ascorbic acid potassium salt, L-Sulfate tocopherylglucoside, L-B-tocopherylmaltoside, L-y- ascorbic acid magnesium salt, L-sulfate ascorbic acid cal tocopherylglucoside, L-y-tocopherylmaltoside, L-6- cium salt, L-Sulfate ascorbic acid aluminum salt, L-sodium tocopherylglucoside, L-8-tocopherylmaltoside, ascorbate salt, L-potassium ascorbate salt, L-magnesium 1-(Sulphoethylamino)-3-(o-tocopheryl-6-yloxy)propan-2- ascorbate salt, L-calcium ascorbate salt, L-aluminum ascor ol. 1-(carboxypropylamino)-3-(o-tocopheryl-6-yloxy)pro bate salt, 6-O-O-D-galactopyranosyl-L-ascorbic acid, 2-o-B- pan-2-ol hydrochloride, S-3-(o-tocopheryl-6-yloxy)-2-hy D-galactopyranosyl-L-ascorbic acid, an L-ascorbic acid droxypropylcystein, S-3-(o-tocopheryl-6-yloxy)-2- magnesium phosphate salt, an L-ascorbic acid sodium phos hydroxypropyl-y-glutamyl cystenyl glycine, N-3-(C- phate salt, an L-ascorbic acid sodium sulfate salt, a 6-o- tocopheryl-6-yloxy)-2-hydroxypropyl)aspartic acid, and acylascorbic acid sodium phosphate salt, a 6-O-acylascorbic N-3-(o-tocopheryl-6-yloxy)-2-hydroxypropylglutamic acid ammonium phosphate salt, a 6-O-acylascorbic acid acid); tocotrienol, a salt thereof, or a derivative thereof (such isopropanolamine salt, a 3-O-isopropyl-L-ascorbic acid, a as C-tocotrienol, B-tocotrienol, Y-tocotrienol, 8-tocotrienol, 6-O-alkylascorbic acid potassium phosphate salt, a 6-o- tocotrienol acetate, tocotrienol nicotinate, tocotrienol Succi alkylascorbic acid calcium phosphate salt, a 6-O-alkylascor nate, tocotrienollinoleate, and tocotrienol orotate); and kojic bic acid barium phosphate salt, a 6-O-alkylascorbic acid acid or a derivative -thereof (2-methoxymethyl-hydorxy ammonium phosphate salt, a 6-O-alkylascorbic acid mono 4H-pyran-4-one, 2-ethoxymethyl-5-hydroxy-4H-pyran-4- ethanolamine phosphate salt, a 6-O-alkylascorbic acid one, 2-benzoyloxymethyl-5-hydroxy-4H-pyran-4-on, 2-cin US 2006/0165636 A1 Jul. 27, 2006 namoyloxymethyl-5-hydroxy-4H-pyran-4-one, quinone B-L-glucose, hydroquinone C-D-galactose, hydro 2-phenoxymethyl-5-hydroxy-4H-pyran-4-one, a kojic acid quinone B-D-galactose, hydroquinone C-L-galactose, or glycoside, geranyl acetone, kojic acid monobutyrate, kojic hydroquinone B-L-galactose; a pentose glycoside such as acid monocaprate, kojic acid monopalmitate, kojic acid hydroquinone C-D-ribose, hydroquinone B-D-ribose, hyd monostearate, kojic acid monocinnamate, kojic acid roquinone C-L-ribose, hydroquinone B-L-ribose, hydro monobenzoate, kojic acid dibutyrate, kojic acid dipalmitate, quinone C-D-arabinose, hydroquinone B-D-arabinose, hyd kojic acid distearate, or kojic acid dioleate). roquinone C-L-arabinose, or hydroquinone B-L-arabinose; 0032 Examples of the compound further include oxy an aminoglycoside Such as hydroquinone C-D-glucosamine, benZone, benzophenone, guaiaZulen, sinicon, baicalin or a hydroquinone B-D-glucosamine, hydroquinone C-L-glu salt thereofor, derivatives thereof, baicalein or a salt thereof cosamine, hydroquinone B-L-glucosamine, hydroquinone or derivatives thereof, berberine or a salt thereof or deriva C-D-galactosamine, hydroquinone B-D-galactosamine, hyd tives thereof, chrysin or a salt thereof or derivatives thereof, roquinone C-L-galactosamine, or hydroquinone B-L-galac apigenin or a salt thereof or derivatives thereof, lutherolin-or tosamine; a hydroquinone glycoside of a uronate glycoside a salt thereof or derivatives thereof, acacetin or a salt thereof Such as hydroquinone C-D-glucuronate, hydroquinone B-D- or derivatives thereof, diosmetin or a salt thereof or deriva glucuronate, hydroquinone C-L-glucuronate, hydroquinone tives thereof, kaempferol or a salt thereof or derivatives B-L-glucuronate, hydroquinone C-D-galacturonate, hydro thereof, triforine or a salt thereof or derivatives thereof, quinone 3-D-galacturonate, hydroquinone C-L-galactur astragalin or a salt thereof or derivatives thereof, quercetin onate, or hydroquinone B-L-galacturonate; and a hydro or a salt thereof or derivatives thereof, quercitrin or a salt quinone hydroxyalkylether glycoside Such as hydroquinone thereof or derivatives thereof, isoquercitrin or a salt thereof benzylether, 4-3-D-glucopyranosyloxy-1-(4-hydroxyphe or derivatives thereof, rutin or a salt thereof or derivatives noxy)butane, 5-B-D-glucopyranosyloxy-1-(4-hydroxyphe thereof, morin or a salt thereof or derivatives thereof, noxy)pentane, 6-3-D-glucopyranosyloxy-1-(4-hydroxyphe myricetin or a salt thereof or derivatives thereof, myricitrin noxy)hexane, 2-3-D-glucopyranosyloxy-1-(4- or a salt thereof or derivatives thereof, dachiscetin or a salt hydroxyphenoxy)propane, 2-3-D-glucopyranosyloxy-1-(4- thereof or derivatives thereof, quercetagetin or a salt thereof hydroxyphenoxy)butane, or 2-3-D-glucopyranosyloxy-1- or derivatives thereof, isorhamnetin or a salt thereof or (4-hydroxyphenoxy)propane-3-ol. derivatives thereof, pinosembrin or a salt thereof or deriva 0034) Examples of the compound further include: an tives thereof, naringenin or a salt thereof or derivatives isonitrile antibiotic Such as isonitrin A, isonitrin B, isonitrin thereof, hesperetin or a salt thereof or derivatives thereof, C, isonitrin D, isonitrate E, isonitrate F, delmadein, or eriodictyol or a salt thereof or derivatives thereof, tricobilidein; an orseillin derivative such as orsellinate, pinobanksin or a salt thereof or derivatives thereof, aroma ethylester orcinolorseillinate, p-geranylorseillinate, p-ethy dendrin or a salt thereof or derivatives thereof, engelitin or lester geranylorcinol geranylorseillinate, p-farnesylorseilli a salt thereof or derivatives thereof, taxofolin or a salt nate, p-ethylester farnesylorcinol farnesylorsellinate, thereof or derivatives thereof, astilbin or a salt thereof or p-dodecanylorseillinate, p-ethylester dodecanylorcinol derivatives thereof, ampelopsin or a salt thereof or deriva dodecanylorseillinate, p-tetradecanylorseillinate, p-ethyl tives thereof, glutathion or a salt thereof or derivatives ester tetradecanylorcinol tetradecanylorseillinate, p-hexade thereof, an isoflavone glycoside (6-O-apiosylpuerarin-4'-O- canylorseillinate, p-ethylester hexadecanylorcinol hexade glucoside, 6-O-glucosylpuerarin, 3'-hydroxypuerarin-4'-O- canylorseillinate, p-undecanylorseillinate, p-ethylester glucoside, 6-o-apiosyl-3'-hydorXypuerarin, or the like), a undecanylorcinol undenacylorseillinate, p-tridecanylorseil y-pyrone glycoside (maltol-3-O-(6'-o-apiosyl)-glucoside, linate, p-ethylester undecanylorcinol tridecanylorseillinate, maltol-3-O-(6'-o-apiosyl)-glucoside, or the like), p-pentadecanylorseillinate, p-ethylester pentadecanylorci isononylferulate, elagic acid or a salt thereof or derivatives nol pentadecanylorseillinate, ethylhexylorseillinate, p-ethy thereof (5,4-dimetyl elagic acid, 3,3'-dimethyl ellagic acid, lester ehtylhexylorcinol ethylhexylorseillinate, p-cyclo 3.3',4-trimethyl ellagic acid, 3,3,4,4-tetramethyl-5-meth hexylmethylorseillinate, p-ethylester oxy ellagic acid, 3-ethyl-4-methyl-5-hydroxy elagic acid, cylcohexylmethylorcinol cyclohexylmethylorseillinate, amritoside, and the like), rucinol, onjisaponin, Ophiopogo p-hydroxyethylhexylorseillinate methylester, or p-hydroxy nis Saponin, ruscogenin, sericoside, asiaticoside, hederin, ethylhexylorseillinate hydroxyethylhkylorcinol; umbellic Senegin, benzoic anilides (4-hydroxy-N-(2-hydroxyphenyl acid; breferdin; oxydesveratrol; a resorcinol derivative )benzoic amide, 4-hydroxy-N-(3-hydroxyphenyl)benza (4-cyclohexylresorcinol); a 3-hydroxyketone compound mide, 4-hydroxy-N-(4-hydroxyphenyl)benzamide, 3,5-di-t- Such as 1.5-bis(p-hydroxyphenyl)-2-hydroxypentane-4-one, butyl-4-hydroxy-N-(4-hydroxyphenyl)benzamide, 3,5-di-t- 1.5-bis(op-dihydroxyphenyl)-2-hydroxypentane-4-One, or butyl-4-hydroxy-N-(3-hydroxyphenyl)benzamide, 3,5-di-t- 1.5-bis(p-hydroxyphenyl-m-methoxyphenyl)-2-hydroxy butyl-4-hydroxy-N-(2-hydroxyphenyl)benzamide, and the pentane-4-one; a 1,3-diketone compound such as 1.5-bis(p- like), diphenylpiralin, cyproheptadine, triprolidine, dimetin hydroxyphenyl)-2,4-pentanedione, 1.5-bis(op-dihydrox dene, oZagrel, isothipendyl, iproheptine, homochlorcycliz yphenyl)-2,4-pentanedione, or 1.5-bis(p-hydroxyphenyl-m- ine, alimemazine, bucillamine, oXotamide, Vidarabine, Xan methoxyphenyl)-2,4-pentanedione; thotoxol, hexachlorophene phenylmercury, mercuric oxide, bishydroxybenzylamides; Y-aminobutyrate or a derivative mercurous chloride, a hydrogen peroxide Solution, Zinc thereof such as N-methyl-y-aminobutyrate, N-dimethyl-y- peroxide, and a placenta (bovine-derived, porcein-derived, aminobutyrate, or Y-oleylester aminobutyrate; and rucinol. sheep-derived, or the like) extract. 0035 Examples of the compound further include: 0033 Examples of the compound further include hydro lobeline or a lobeline derivative; a rikuiritin derivative such quinone or a salt thereof or derivatives thereof including: a as rikuiritin-O-glucoside or rikuiritin-O-maltoside; a phenyl hexose glycoside Such as hydroquinone C-D-glucose, hyd chroman derivative; a chromone derivative such as 2-butyl roquinone B-D-glucose, hydroquinone C-L-glucose, hydro chromone, 2-pentylchromone, 2-heptylchromone, 2-nonyl

US 2006/0165636 A1 Jul. 27, 2006 none(2',4'-dihydroxyacetophenone), 1-(2,4-dihydroxyphe glucoside Salicylic acid, fatty acid ester salicylic acid, alco nyl)-1-propanone(2',4'-dihydroxypropiophenone), 1-(2,4- hol ether salicylic acid, and Salicylic acid amides; Salicyl dihydroxyphenyl)-1-butanone, 1-(2,4-dihydroxyphenyl)-1- alcohol, a salt thereof, or derivatives thereof apigenin: pentanone, 1-(2,4-dihydroxyphenyl)-1-hexanone, 1-(2,4- amentoflavone; ethylene oxide; ethylene glycol, diethylene dihydroxyphenyl)-1-heptanone, 1-(2,4-dihydroxyphenyl)-1- glycol; triethylene glycol; ethylene glycol monoethyl ether; octanone, 1-(2,4-dihydroxyphenyl)-1-nonanone, 1-(2,4- ethylene glycol monobutyl ether; diethyleneglycol monom dihydroxyphenyl)-1-decanone, 1-(2,4-dihydroxyphenyl)-1- ethyl ether; diethylene glycol monoethyl ether; propylene undecanone, 1-(2,4-dihydroxyphenyl)-1-dodecanone, 1-(2, oxide; propylene glycol; 1,3-butylene glycol; pentylglycol, 4-dihydroxyphenyl)-1-tetradecanone, 1-(2,4- glycerin; polyalcohols such as erythritol, pentaerythritol, dihydroxyphenyl)-1-hexadecanone, 1-(2,4- dipentaerythritol, threitol, arabitol, xylitol, ribitol, galactitol, dihydroxyphenyl)-1-octadecanone, 1-(2-hydroxy-4- Sorbitol, mannitol, lactitol, maltitol, sitiritol, laminitol, valie methoxyphenyl)-ethanone(2'-hydroxy-4'- namine, validamine, and validatol; a saccharide or ester methoxyacetophenone), 1-(2-hydroxy-4-methoxyphenyl)-1- thereof Such as glucose, galactose, mannose, Xylose, fruc propanone(2'-hydroxy-4-methoxypropiophenone), 1-(2- tose, maltose, isomaltose, cellobiose, gentiobiose, trehalose, hydroxy-4-methoxyphenyl)-1-butanone, 1-(2-hydroxy-4- kojibiose, laminaribiose, nigerose, Sanbebiose, neohesperi methoxyphenyl)-1-pentanone, 1-(2-hydroxy-4- dose, apiose, hamamelose, Streptose, hydroxystreptose, methoxyphenyl)-1-hexanone, 1-(2-hydroxy-4- dihydrostreptose, 2-methylerythrose or a derivative thereof methoxyphenyl)-1-heptanone, 1-(2-hydroxy-4- (trehalose undecylenic acid or the like), 2-methylerythrono methoxyphenyl)-1-octanone, 1-(2-hydroxy-4- lactone, micarose, cladinose, accenose, alcanose, olivomi methoxyphenyl)-1-nonanone, 1-(2-hydroxy-4- cose, chromose, evemicose, Vinerose, nogarose, Virenose, methoxyphenyl)-1-decanone, 1-(2-hydroxy-4- nobiose, moenuronic acid, garosamin, sibilosamin, N-acyl methoxyphenyl)-1-undecanone, 1-(2-hydroxy-4- kansosamin, bancosamin, evenitrose, rubranitrose, tetroni methoxyphenyl)-1-dodecanone, 1-(2-hydroxy-4- trose, pyrarose, C.-Octose, trioxacalcinose, aldogarose, or methoxyphenyl)-1-tetradecanone, 1-(2-hydroxy-4- blastminocin; trehalose or a derivative thereof D-man methoxyphenyl)-1-hexadecanone, 1-(2-hydroxy-4- nosamin and a derivative thereof, and primeverose or a methoxyphenyl)-1-octadecanone, 1-(4-hydroxy-2- derivative thereof. methoxyphenyl)-ethanone(4'-hydroxy-21 0042 Examples of the compound further include: sodium methoxyacetophenone), 1-(4-hydroxy-2-methoxyphenyl)-1- lactate; hydantoin and a derivative thereof: N-p-vinylben propanone(4'-hydroxy-2-methoxypropiophenone), 1-(2,4- Zyl-D-cellobionamide, N-p-vinylbenzyl-D-lactonamide; dimethoxyphenyl)-ethanone(2',4'-dimethoxyacetophenone), N-p-vinylbenzyl-D-maltonamide: N-p-vinylbenzyl-D-glu 1-(2,4-dimethoxyphenyl)-1-propanone(2',4'-dimethoxypro conamide; glucosyloxyethyl methacrylate; galactosylox piophenone), a lactone derivative (such as 1,6-dioxaspiro ypropyl acrylate; mannosiloxyethyl methacrylate; glutamyl 4.4nonane-2,7-dione, 1,6-dioxaspiro4.5decane-2,7-di lysine; glutaurine; 1,2,4-butanetriol, kalan-3,4-diol; and red one, 4-tridecanolide, 4-dodecanolide, 4-undecanolide, beans saponin (3-o-B-D-glucopyranosyl-B-D-glucuronopy 4-decanolide, 4-nonanolide, 4-octanolide, 4-heptanolide, ranosyl-Sophoradiol, 3-o-B-D-glucopyranosyl-3-D-glucu 5-dodecanolide, 5-undecanolide, 5-decanolide, 5-nonano ronopyranosyl-soya sapogenol B, 3-O--D-glucopyranosyl lide, 5-octanolide, 2-undecene-4-olide, 2-decene-4-olide, f-D-glucuronopyranosyl-adsuki sapogenol, 3-o-f3-D- 2-nonene-4-olide, 2-heptene-4-olide, 2-undecene-5-olide, glucopyranosyl-28-O-B-D-glucopyranosyl-f-D- 2-decene-5-olide, 2-nonene-5-olide, 2-octene-5-olide, 4-me glucopyranosyl-dipsogenic acid, 3-O-O-L- thyl-4-dodecanolide, 4-methyl-4-undecanolide, 4-methyl-4- rhamnopyranosyl-B-D-glucopyranosyl-B-D- decanolide, 4-methyl-4-nonanolide, 4-methyl-4-heptano glucuronopyranosyl-soya sapogenol B, 3-o-f-D- lide, 5-methyl-5-dodecanolide, 5-methyl-5-undecanolide, glucopyranosyl-B-D-glucuronopyranosyl-29-o-B-D- 5-methyl-5-decanolide, 5-methyl-5-nonanolide, 5-methyl-5- glucopyranosyl-B-D-glucopyranosyl-adzuki Sapogenol, octanolide, 2-methoxycarbonyl-4-dodecanolide, 2-meth oxycarbonyl-4-undecanolide, 2-methoxycarbonyl-4-de and the like). canolide, 2-methoxycarbonyl-4-nonanolide, 0043. Examples of the compound further include: retinol, 2-methoxycarbonyl-4-heptanolide, 2-methoxycarbonyl-5- a salt thereof, or derivatives thereof (retinol unsaturated undecanolide, 2-methoxycarbonyl-5-decanolide, 2-meth aliphatic ester Such as retinyl linoleate, retinyl linolenate, oxycarbonyl-5-nonanolide, 2-methoxycarbonyl-5-octano retinyl oleate, or retinyl arachidonate); retinal, a salt thereof, lide, 2-allyl-4-undecanolide, 2-allyl-5-decanolide, 2-allyl-4- or derivatives thereof; dehydroretinal, a salt thereof, or nonanolide, 2-pentyl-4-undecanolide, 2-pentyl-4- derivatives thereof retinoic acid, a salt thereof, or deriva nonanolide, 2-methyl-4-undecanolide, 2-methyl-4- tives thereof; retinoic acid analogues (4-8-(3,5-dimeth nonanolide, 2-(4-hydroxybutyl)-4-undecanolide, 2-(4- ylphenyl)-2-naphthalenylcarbonylaminobenzoic acid, hydroxybutyl)-4-nonanolide, 2-(4-hydroxybutyl)-5- 4-8-(3-methylphenyl)-2-naphthalenyl)carbonyl)amino decanolide, 5-propyloxy-4-pentanolide, 5-allyloxy-4- benzoic acid, 4-8-(4-methylphenyl)-2-naphthalenylcar pentanolide, 5-(2-hydroxyethoxy)-4-pentanolide, bonyl)aminobenzoic acid, 4-8-(2-methylphenyl)-2-naph thalenylcarbonyl)aminobenzoic acid, 4-8-(3,4- 8-hydroxy-4-octanolide, 6-propyloxy-5-hexanolide, 6-ally dimethylphenyl)-2-naphthalenylcarbonylaminobenzoic loxy-5-hexanolide, 6-(2-hydroxyethoxy)-5-hexanolide, or acid, 4-8-(2,4-dimethylphenyl)-2-naphthalenylcarbonyl 9-hydroxy-5-nonanolide), echinomycin, iriflorental, iri aminobenzoic acid, 4-8-(2-isopropylphenyl)-2-naphtha paridal, 2-8-C-glucosyl-7-methylaloesolcoumaroylester, lenylcarbonyl)aminobenzoic acid, 4-8-(2-ethylphenyl)- 2-8-C-glucosyl-7-methylaloesolcinnamoylester, and chlo 2-naphthalenylcarbonylaminobenzoic acid, 4-8-(2- ropyramine. fluorophenyl)-2-naphthalenylcarbonylaminobenzoic acid, 0041 Examples of the compound further include: sali 4-8-(2-methoxyphenyl)-2-naphthalenylcarbonylamino cylic acid, a salt thereof, or derivatives thereof such as benzoic acid, 4-(8-benzyl-2-naphthalenyl)carbonyl US 2006/0165636 A1 Jul. 27, 2006 aminobenzoic acid, and 4-(E)-2-(8-phenyl-2-naphthale phenyl-1H-indene-5-yl) vinylbenzoic acid, and 4-(1,1- nyl)propenylbenzoic acid); a retinoic acid derivative such dimethyl-3-phenyl-1H-indene-5-carbonyl)aminobenzoic as 4-hydroxyphenylretinamide; and retinoid analogues such acid. as 4-(5,6-dihydro-5,5-dimethyl-8-ethyl-2-naphthaleny 0044) Examples of the compound further include: caro l)aminocarbonylbenzoic acid, 4-(5,6-dihydro-5,5,8-trim tin, a salt, or derivatives thereof (carotenoids Such as C-ca ethyl-2-naphthalenyl)aminocarbonylbenzoic acid, 4-(5. rotin, B-carotin, Y-carotin, lycopene, cryptoXanthin, lutein, 6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)amino Zeaxanthin, isoZeaxanthin, rhodoxanthin, capsanthin, and carbonylbenzoic acid, 4-(5,6-dihydro-5,5-dimethyl-8- crocetin); lycopene, a salt, or derivatives thereof; thiamine, ethyl-2-naphthalenyl)carbonyl)aminobenzoic acid, 4-(5. a salt, or derivatives thereof (thiamine hydrochloride, thia 6-dihydro-5,5,8-trimethyl-2-naphthalenyl)-carbonyl)amino mine disulfide, bisbenthiamine, bisibuthiamine, thiamine benzoic acid, 4-(E)-2-(5,6-dihydro-5,5-dimethyl-8-phenyl monophosphate disulfide, benfothiamine, cycotiamine, 2-naphthalenyl)-1-propenylbenzoic acid, 4-(5,6-dihydro octothiamine, dicethiamine, fursulthiamine, proSulthiamine, 5,5-dimethyl-8-phenyl-2-naphthalenyl)oxycarbonyl and astaxanthin thiamine phosphodiester); thiamine Sulfate; benzoic acid, 4-(5,6-dihydro-5,5-dimethyl-8-phenyl-2- riboflavin, a salt, or derivatives thereof (such as flavin (naphthalenyl)carbonyl)aminobenzoic acid, 4-(5.6- adenine dinucleotide, flavin mononucleotide, riboflavin dihydro-5,5-dimethyl-8-phenyl-2-(naphthalenyl)carbonyl phosphodiester, 1-3-D-riboflanosyl nicotinamide pyrophos oxybenzoic acid, 4-5,6-dihydro-5,5-dimethyl-8-(2- phate diester, and 1-3-D-riboflanosyl nicotinate); pyridox fluorophenyl)-naphthalenylcarbonylaminobenzoic acid, ine, a salt, or derivatives thereof (such as 3.4-pyridoxine 4-(5,6-dihydro-5,5,6-trimethyl-8-phenyl-2-(naphthale dipalmitate, 3.4-pyridoxine dicaprylic acid, and disulfate nyl)carbonyl)aminobenzoic acid, 4-(5,6-dihydro-5,5,7- pyridoxine); pyridoxal, a salt, or derivatives thereof; pyri trimethyl-8-phenyl-2-naphthalenyl)carbonylbenzoic acid, doxamine, a salt, or derivatives thereof cyanocobalamin, a 4-(E)-(5,6-dihydro-5,5-dimethyl-8-phenyl)-2-naphthale salt, or derivatives thereof: cobalamins (such as methylco nylvinylbenzoic acid, 4-(5,6-dihydro-5,5-dimethyl-8- balamin, adenosylcobalamin, hydroxocobalamin, and aqua phenyl)-2-naphthalenylcarbonylsulfamylbenzoic acid, cobalamin); folic acid, a salt, or derivatives thereof, nico 4-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl tinic acid, a salt, or derivatives thereof; pantothenic acid, a sulfamylcarbonylbenzoic acid, 4-(5,6-dihydro-5,5-dim salt, or derivatives thereof biotin, a salt, or derivatives ethyl-8-phenyl)-2-naphthalenylethylbenzoic acid, 4-(5. thereof choline, a salt, or derivatives thereof, and inositol, 6-dihydro-5,5-dimethyl-8-phenyl)-2-naphthalenyl a salt, or derivatives thereof. thiocarbonylaminobenzoic acid, 4-(5,6-dihydro-5,5- dimethyl-8-phenyl)-2-naphthalenylcarbonyl)methyl 0045 Examples of the compound further include: ergo benzoic acid, 4-(5,6-dihydro-5,5-dimethyl-8-phenyl)-2- calciferol, a salt thereof, orderivatives thereof cholecalcif naphthalenyl)methyloxybenzoic acid, 4-(5,6-dihydro-5, erol, a salt therof, or derivatives thereof (such as 1C.-hy 5-dimethyl-8-phenyl)-2-naphthenyloxymethylbenzoic droxy-22-(1-hydroxy-1-methyl)-2-cyclopentene-4-yl-oxy acid, 4-(5,6-dihydro-5,5-dimethyl-8-(2,4-dimethylphe 23.24.25.26.27-pentanolcholecalciferol, 1R,4R-1C.- nyl)-2-naphthalenylcarbonyl)aminobenzoic acid, 4-(5. hydroxy-22-(1-hydroxy-1-methyl)-2-cyclopentene-4-yl 6-dihydro-5,5-dimethyl-8-(4-methylphenyl)-2-naphthale oxy-23.24.25.26.27-pentanolcholecalciferol, 1 R,4S-la nylcarbonyl)aminobenzoic acid, 4-(5,6-dihydro-5,5- hydroxy-22-(1-hydroxy-1-methyl)-2-cyclopentene-4-yl dimethyl-8-phenyl)-2-naphthalenylethylbenzoic acid, oxy-23.24.25.26.27-pentanolcholecalciferol. 1S,4R-1C.- 4-(5,6-dihydro-5,5-dimethyl-8-phenyl)-2-naphthalenyl hydroxy-22-(1-hydroxy-1-methyl)-2-cyclopentene-4-yl sulfamylmethylbenzoic acid, 4-(5,6-dihydro-5,5-dim oxy-23.24.25.26.27-pentanolcholecalciferol, and 1S,4S ethyl-8-phenyl)-2-naphthalenylmethylamino)benzoic 1O-hydroxy-22-(1-hydroxy-1-methyl)-2-cyclopentene-4- acid, 4-(5,6-dihydro-5,5-dimethyl-8-phenyl)-2-naphtha yl-oxy-23.24.25.26.27-pentanolcholecalciferol): lenylaminothiocarbonylbenzoic acid, 4-(5,6-dihydro-5, dihydrotachysterol, a salt thereof, or derivatives thereof; 5-dimethyl-8-phenyl)-2-naphthalenyl)methylsulfamylben phytonadione, a salt thereof, or derivatives thereof; Zoic acid, 4-(5,6-dihydro-5,5-dimethyl-8-phenyl-2- menaquinone, a salt thereof, or derivatives thereof mena naphthalenyl)aminomethylbenzoic acid, 4-(5.6- dione, a salt thereof, or derivatives thereof menadiol, a salt dihydro-5,5-dimethyl-8-phenyl)-2-naphthalenylcarbonyl thereof, or derivatives thereof carnitine, a salt thereof, or amino-2-hydroxybenzoic acid, 4-(5,6-dihydro-5,5- derivatives thereof feruilic acid, a salt thereof, or deriva dimethyl-8-phenyl)-2-naphthalenylcarbonyl)amino-2- tives thereof; y-olizanol, a salt thereof, or derivatives nitrobenzoic acid, 4-(5,6-dihydro-5,5-dimethyl-8- thereof, orotic acid, a salt thereof, or derivatives thereof; phenyl)-2-naphthalenylcarbonylamino-2-fluorobenzoic rutin, a salt thereof, or derivatives thereof. eriocitrin, a salt acid, 4-(5,6-dihydro-5,5-dimethyl-8-phenyl-2-naphthale thereof, or derivatives thereof; hesperidin, a salt thereof, or nyl)carbonyl)amino-2-methoxybenzoic acid, 4-(5,6-di derivatives thereof. Vitamin L complex: anthranilic acid, a hydro-5,5-dimethyl-8-(2-naphthalene))-2-naphthalenylcar salt thereof, or derivatives thereof adenylthiomethylpen bonyl)aminobenzoic acid, 4-(5,6-dihydro-8-phenyl-2- tose, a salt thereof, or derivatives thereof; and methylme naphthalenyl)carbonylaminobenzoic acid, 4-(5,6- thionine sulphonium chloride or a derivative thereof. dihydro-5,5-dimethyl-8-phenyl-2-naphthalenyl)carbonyl 0046 Examples of the compound further include: valine, amino-3-fluorobenzoic acid, 4-(5,6-dihydro-5,5- leucine, isoleucine, threonine, methionine, phenylalanine, dimethyl-8-phenyl-2-naphthalenyl)carbonyl)amino-3- tryptophan, lysine, glycine, alanine, asparagine, glutamine, methylbenzoic acid, 4-(5,8,10,10a-tetrahydro-10.10 serine, cysteine, cystine, tyrosine, proline, hydroxyproline, dimethyl-9-phenyl-2-anthracenyl)carbonyl)aminobenzoic aspartic acid, glutamic acid, hydroxylysine, arginine, orni acid, 4-(1,1-dimethyl-3-phenyl-1H1-indene-5-yl)amino thine, and histidine and derivatives thereof (N-octyloxycar carbonylbenzoic acid, 4-(1,1-dimethyl-3-phenyl-1H-in bonyl-B-alanyl-L-histidine, N-dodecyloxycarbonyl-3-ala dene-5-yl-oxymethyl)benzoic acid, 4-2-(1,1-dimethyl-3- nyl-L-histidine, N-(12-amino-1-oxododecyl)-L-histidine, US 2006/0165636 A1 Jul. 27, 2006

N-2-ethylhexyloxycarbonyl-3-alanyl-L-histidine hydro temocapril; losartan; endothelin; a galactomannan-saccha chloride, N-hexadecyloxycarbonyl-f-alanyl-L-histidine, ride polymer, mucin; trimethyl glycine; proteoglycan; a N-octylaminocarbonyl-3-alanyl-L-histidine, N-dodecylami lactobacillus extract; a lactobacillus medium extract; a lac nocarbonyl-f-alanyl-L-histidine, N-dodecylsulfonyl-3-ala tobacillus fermented milk extract; a bifidobacterium extract; nyl-L-histidine, N-dodecylamino-oxalyl-3-alanyl-L-histi a bifidobacterium medium extract; a bifidobacterium-fer dine, and the like); Sulfate, phosphate, nitrate, and citrate mented milk extract; a placenta extract; a reishi mushroom (sodium citrate or the like) thereof, amino acids such as a extract; a spleen extract; a thymus extract; an yeast extract; amino acid derivative of pyrrolidone carboxylate or the like: an yeast medium extract; an yeast-fermented extract; a C-hydroxy acids such as glycolic acid, citric acid, malic fungus extract; a fungus medium extract; a basidiomycete acid, tartaric acid, lactic acid, and Succinic acid; 2-hydroxy extract; a basidiomycete medium extract; a bacterial cell carboxylic acids (methylactic acid, 2-hydroxybutanoic acid, homogenized extract; a bacterial medium extract; and a 2-hydroxypentanoic acid, 2-hydroxyhexanoic acid, 2-hy cultured human dermis homogenized extract. droxyheptanoic acid, 2-hydroxyoctanoic acid, 2-hydrox 0048 Examples of the compound further include: a ben ynonanoic acid, 2-hydroxy decanoic acid, 2-hydroxyunde Zochroman derivative; a nordihydroguaseretnic acid; butyl cylic acid, C.-hydroxylauric acid, C-hydroxymyristic acid, hydroxytoluene(BHT): dibutylhydroxytoluene; butylhy C-hydroxypalmitic acid, C-hydroxyStearic acid, C.-hy droxyanisole(BHA); hydroxytyrosol; parahydroxyanisole; droxyarachidonic acid, cerebronic acid, C-hydroxynervonic propyl gallate: Sesamol, Sesamolin; gossypol; maritimein; acid, mandelic acid, benzilic acid, phenylactic acid, atro Sulfuretin; Xanthene-2,7-diols; caffeoylquinic acids; propo lactic acid, 2-(4'-hydroxyphenyl)-2-hydroxyethanoic acid, lis; carotenoids (C-carotene, B-carotene, Y-carotene, lyco 2-(4-chlorophenyl)-2-hydroxyethanoic acid, 2-(3'-hydroxy pene, lutein, violaxanthin, spirilloxanthin, Sphaeroiden, 4'-methoxyphenyl)-2-hydroxyethanoic acid, 2-(4'-hydroxy astaxanthin, and the like), phlorotannin; Superoxide dismu 3'-methoxyphenyl)-2-hydroxyethanoic acid, 3-(2-hydrox tase; catalase; glutathione peroxidase; bilirubin; quercetin: yphenyl)-2-hydroxypropanoic acid, 3-(4-hydroxyphenyl)- quercitrin; catechin; a catechin derivative; rutin or a deriva 2-hydroxypropanoic acid, 2-(3',4'-dihydroxyphenyl)-2- tive thereof gallic acid, a salt thereof, or derivatives thereof; hydroxyethanoic acid, glyceric acid, erythronic acid, ribonic curcumine, a salt thereof, or derivatives thereof; transferrin; acid, arabinonic acid Xylonic acid, lyXonic acid, allonic acid, ceruloplasmin, coenzyme Q; uric acid; bilirubin; metal altronic acid, gluconic acid, mannonic acid, gulonic acid, lothionein; a stilbenegalloyl glycoside (3,5,4'-trihydroxy stil idonic acid, galactonic acid, talonic acid, glucoheptonic benea'-o-f3-D-(6"galloyl)glucopyranoside, 3,5,4'-trihydrox acid, galactoheptonic acid, tartronic acid, mucic acid, and yStilbenea'-o-B-D-(2"galloyl)glucopyranoside, or the like); the like); polyhydroxy carboxylic acids or hydroxypolycar chlorogenic phospholipid ester, chlorogenic sphingosine boxylic acids (gluconolactone, galactonolactone, glucurono ester and a derivative thereof chlorogenic glycolipid ester; lactone, galacturonolactone, glonolactone, ribonolactone, chlorogenic Sugar ester, chlorogenic sterol ester; a thiazole saccharic acid lactone, pantoylactone, glucoheptonolac derivative or a salt thereof (2-(3,4-diethoxyphenyl)-4-(3- tone, mannonolactone, galactoheptonolactone, and the like); carboxy-4-hydroxyphenyl)thiazole, 2-(3,4-diethoxyphe 2-keto acids (glyoxalic acid, methyl 2-ketoethanoic acid, nyl)-4-3-carboxy-4-hydroxy-5-(2-methyl-2-propenyl)phe benzoylformic acid, methylbenzoylformic acid, ethylben nylthiazole, 2-(3,4-diethoxyphenyl)-4-(3-carboxy-4- Zoylformic acid, phenylpyruvic acid, methyl phenylpyruvic hydroxy-5-methylphenyl)thiazole, O 2-(3,4- acid, ethyl phenylpyruvic acid, 2-ketobutanoic acid, 2-ke diethoxyphenyl)-4-(3-carboxy-5-methoxyphenyl)thiazole); topentanoic acid, 2-ketohexanoic acid, 2-ketoheptanoic hydroxymatairesinol; allohydroxymatairesinol; and a acid, 2-ketooctanoic acid, 2-ketododecanoic acid, 2-methyl hydantoin derivative. ketooctanoic acid, and the like); quinic acid; isocitric acid; tropic acid; trethocanic acid; 3-chlorolactic acid; cerebronic 0049. Examples of the compound further include: a acid; citramalic acid; agaricic acid; aroy ricinic acid; pantoic phthalazine derivative such as 4-ethyl-1-(B-hydroxyethy acid; lactobionic acid; hexuronic acid; photosensitive ele lamino)phthalazine, 4-N-propyl-1-(B-hydroxyethylami ment 301; allantoin: glyceride pentadecanoic acid; estradiol; no)phthalazine, 4-N-butyl-1-(B-hydroxyethylamino)ph ethenylestradiol; antiarol or a glycoside thereof, lyoniresinol thalazine, O 4-N-butyl-1-(B- or a glycoside thereof rhododendrol or a glycoside thereof. hydroxypropylamino)phthalazine; a Xanthin derivative Such as caffeine, theophylline, theobromine, Xanthine, amino and platiphylonol or a glycoside thereof. phylline, cholintheophylline, diprophylline, proxyphylline 0047 Examples of the compound further include: lactone or oXtriphylline; a benzophenone derivative Such as 2-hy compounds (D-glucurono-6.3-lactone, C.-D-glucoheptonic droxy-4-methoxybenzophenone, 2-hydroxy-4-methoxyben y-lactone, Ö-glucuronolactone, C.f3-glucooctonic-y-lactone, Zophenone-5-Sulfonic acid, sodium 2-hydroxy-4-methoxy L-glonic-y-lactone, Y-D-galactonolactone, D-saccharic-1,4- benzophenone-5-sulfonic acid, lactone, D-saccharic-3,6-lactone, D-ribonic-y-lactone, dihydroxydimethoxybenzophenone, sodium dihydroxy C.-butyrolactone, Y-butyrolactone, C-octanoiclactone, Y-oc dimethoxybenzophenone Sulfonic acid, 2,4-dihydroxyben tanoiclactone, nonanoiclactone, Y-Valerolactone, D-man Zophenone, or tetrahydroxybenzophenone; and a 1,2-dihy noic-Ö-lactone, D-xyloic-Ö-lactone, D-arabinoic-Ö-lactone, droxy-4-(2-hydroxyethyl)benzene derivative such as 1-(2- Stearoyl-6-gluconolactone, DL-pantolactone, palmitoyl-DL (4-(3,4-dihydroxycinnamoyl)-3-rhamnosyl)glucosyl)ethyl pantolactone, and the like), 3-hydroxy-3,4-dicarboxy-1,4- 3-hydroxy-4-methoxybenzene, 1-(2-(6-(3,4- butanolide or a derivative thereof; 6-benzylaminopurine or a dihydroxycinnamoyl)-3-rhamnosyl)glucosyl)ethyl-3- derivative thereof; 1,4-diaza bicyclooctane; 2,5-dimethyl hydroxy-4-methoxybenzene, 1-(2-(2-actyl-4-(3,4- furan: 2-methylfuran; 2,5-diphenylfuran; 1,3-diphenyl dihydroxycinnamoyl)-3-rhamnosyl)glucosyl)ethyl-3,4- isobenzofuran, rutin; tectorigenin 7-Xylosylglucoside; cap dihydroxybenzene, 1-(2-(2-actyl-6-(3,4- topril; alacepril; lisinopril; enalapril; delapril; benazepril; dihydroxycinnamoyl)-3-rhamnosyl)glucosyl)ethyl-3,4- cilaZapril; imidapril; quinapril; trandelapril; perindopril; dihydroxybenzene, 1-(2-(4-(3,4-dihydroxycinnamoyl)-3- US 2006/0165636 A1 Jul. 27, 2006 rhamnosyl)glucosyl)ethyl-3,4-dihydroxybenzene, 1-(2-(6- tetramethyl-6'-hydroxychroman; an L-carnosine Zinc (4-hydroxy-3-methoxycinnamoyl)-3- complex; umbelliferone; aesculin; benzyl cinnamate; cino rhamnosyl)glucosyl)ethyl-3,4-dihydroxybenzene, 1-(2-(4- Xate; oxybenzone; dioxybenzone; octabenZone, Sulisoben (3,4-dihydroxycinnamoyl)-3-rhamnosyl)glucosyl)-1- Zone; benzoresorcinol; arbutin; guaiaZulen; shikonin; baica methoxyethyl-3,4-dihydroxybenzene, 1-(2-(4-(3,4- lin; baicalein; berberine; neoheliopan; chlorophylls; dihydroxycinnamoyl)-3-rhamnosyl)glucosyl)-1- Xanthophylls; escarole; Zinc oxide; talc, and kaolin. hydroxyethyl-3,4-dihydroxybenzene, 1-(2-(6-(3,4- 0051 Examples of the compound further include: zinc dihydroxycinnamoyl)-3-Xylosyl)glucosyl)ethyl-3,4- Sulfate; Zinc oxide; calamine; Zinc p-phenolsulfonic acid; dihydroxybenzene, 1-(2-(3-allosyl-6-(3-hydroxy-4- potassium aluminium Sulfate; resorcin; ferric chloride; tan methoxycinnamoyl))glucosyl)ethyl-3,4-dihydroxybenzene, nins such as tannic acid, hamamelitannin, acertannin, gal 1-(2-(3-glucosyl-6-(3-hydroxy-4-methoxycinnamoyl))glu lotannin including tetragalloyl glucose, pentagalloyl glu cosyl)ethyl-3-hydroxy-4-methoxybenzene, 1-(2-(3-allosyl cose, hxagalloyl glucose, heptagalloyl glucose, octagalloyl 6-(3-hydroxy-4-methoxycinnamoyl)glucosyl)ethyl-3-hy glucose, nonagalloyl glucose, decagalloyl glucose, undeca droxy-4-methoxybenzene, 1-(2-(4-(3,4- galloyl glucose, or dodecagalloyl glucose, and elagitannins dihydroxycinnamoyl)glucosyl)ethyl)-3,4- including tellima glandin I, tellima glandin II, casuaricultin, dihydroxybenzene, 1-(2-(3-(3,4- pedunclagin, geranin, isotarcebin, granatin A, granatin B, dihydroxycinnamoyl)glucosyl)ethyl)-3,4- chebulic acid, chebulagic acid, casualinin, nufalin, procya dihydroxybenzene, 1-(2-(2-(3,4- nidin B-2, thiasinensin A, and thiasinensin B; a quinolinon dihydroxycinnamoyl)glucosyl)ethyl)-3,4- derivative; a dibenzoxepin derivative; thiotropocin; a dihydroxybenzene, O 1-(2-(6-(3,4- phthalimide derivative; a flurbiprofen; felbinac; bufexamac: dihydroxycinnamoyl)glucosyl)ethyl)-3,4- Suprofen; a 1,4-diphenylpropylpyperadine derivative; a dihydroxybenzene. calxine compound; a chromanol glycoside Such as 2-(C-D- 0050 Examples of the compound further include: a glucopyranosyl)methyl-2.5.7,8-tetramethylchroman-6-ol); p-aminobenzoic acid derivative Such as p-aminobenzoic ichthammol; indomethacin; kaolin; diphenhydramine acid, ethyl p-aminobenzoic acid, glyceryl p-aminobenzoic hydrochloride; d-camphor, DL-camphor; salicylate; sodium acid, amyl p-dimethylaminobenzoic acid, or octyl p-dim salicylate; methyl salicylate; acetyl salicylate; hydrocorti ethylaminobenzoic acid; a methoxycinnamic acid derivative Sone; guaiaZulen; chamaZulen; chlorpheniramine maeate; Such as ethyl p-methoxycinnamic acid, isopropyl p-meth diphenhydramine hydrochloride; clemastine fumarate; oxycinnamic acid, octyl p-methoxycinnamic acid, p-meth cyproheptadine hydrochloride; promethazine hydrochloride; oxycinnamic acid-2-ethoxyethyl, sodium p-methoxycin a pyperadine derivative; and an O-D-phenylglucoside namic acid, potassium p-methoxycinnamic acid, or di-B- derivative. methoxycinnamic acid-mono-2-ethylhkananic acid 0052 Examples of the compound further include: gly glyceryl; an anthranilic acid derivative Such as methyl cyrrhizic acid, a salt thereof, and derivatives thereof such as anthranilic acid; an urocanic acid derivative Such as urocanic C-glycyrrhizic acid, B-glycyrrhizic acid, C.-glycyrrhizic acid acid or ethyl urocanic acid; a coumarin derivative; an amino methyl ester, B-glycyrrhizic acid methyl ester, C-glycyr acid-based compound; a benzotriazole derivative; a tetrazole rhizic acid trisodium, C-glycyrrhizic acid monopotassium, derivative; an imidazoline derivative; a pyrimidine deriva C-glycyrrhizic acid dipotassium, C-glycyrrhizic acid tive; a dioxane derivative; a camphor derivative; a furan monoammonium, B-glycyrrhizic acid trisodium, B-glycyr derivative; a pyrone derivative; a nucleic acid derivative; an rhizic acid monopotassium, 3-glycyrrhizic acid dipotassium, allantoin derivative; a nicotinic acid derivative; a pyridoxine and B-glycyrrhizic acid monoammonium; glycyrrhetic acid, derivative; a pyridoxal derivative; a pyridoxamine deriva a salt thereof, or derivatives thereof such as C-glycyrrhetic tive; amentoflavone; neosakuranin; 6-dehydrokawain; a tri acid, B-glycyrrhetic acid, Stearyl C-glycyrrhetic acid, Stearyl azine derivative such as 4,4'4"-(1,3,5-triazine-2,4,6-triyltri B-glycyrrhetic acid, C-glycyrrhetic acid pyridoxine, B-gly imino)trisbenzoic acid tris-2-ethylhexyl or the like; a cyrrhetic acid pyridoxine, C-glycyrrhetic acid glycerin, phosphatidylchromanol derivative Such as 1,2-dilaurorylg B-glycyrrhetic acid glycerin, and 3-succinyloxyglycyrrhetic lycero-3-phospho-2'-hydroxymethyl-2',5'7".8-tetramethyl acid disodium; pantenol, a salt thereof, or derivatives thereof 6'-hydroxychroman, 1,2-dimyristoylglycero-3-phospho-2'- Such as mefenamic acid, phenylbutaZone, ibuprofen, keto hydroxymethyl-2',5'7".8-tetramethyl-6'-hydroxychroman, profen, allantoin, calcium pantothenate, and pantothenyl 1,2-dipalmitoylglycero-3-phospho-2'-hydroxymethyl-2',5'., ethyl ether, e-aminocaproic acid; diclofenac sodium; tran 7,8-tetramethyl-6'-hydroxychroman, 1,2-distearoylglycero examic acid or a derivative thereof Such as trans-4-benzyl 3-phospho-2'-hydroxymethyl-2',5'7".8-tetramethyl-6'-hy oxycarbonylaminomethyl cyclohexanecarboxylic acid, droxychroman, 1.2-diarachidonylglycero-3-phospho-2'- trans-4-3-nitrobenzyl oxycarbonylaminomethyl cyclohex hydroxymethyl-2',5'7".8-tetramethyl-6'-hydroxychroman, anecarboxylic acid, trans-4-3-chlorobenzyl oxycarbony 1-myristoyl-2-palmitoylglycero-3-phospho-2'-hydroxym laminomethyl cyclohexanecarboxylic acid, trans-4-3-bro ethyl-2',5'7".8-tetramethyl-6'-hydroxychroman, 1-myris mobenzyl oxycarbonylaminomethyl cyclohexanecarboxylic toyl-2-stearoylglycero-3-phospho-2'-hydroxymethyl-2',5'., acid, trans-4-m-chlorobenzyloxy carbonylaminomethyl 7,8-tetramethyl-6'-hydroxychroman, 1-palmitoyl-2- cyclohexanecarboxylic acid, trans-4-3-methoxybenzyloxy myristoylglycero-3-phospho-2'-hydroxymethyl-2',5'.7.8'- carbonylaminomethyl cyclohexanecarboxylic acid, trans-4- tetramethyl-6'-hydroxychroman, 1-palmitoyl-2- B-methylbenzyloxy carbonylaminomethyl cyclohexanecar stearoylglycero-3-phospho-2'-hydroxymethyl-2',5'7".8- boxylic acid, trans-4-benzyloxy carbonylaminomethyl tetramethyl-6'-hydroxychroman, 1-stearoyl-2- cyclohexanecarboxylic acid sodium, trans-4-3-nitrobenzy myristoylglycero-3-phospho-2'-hydroxymethyl-2',5'.7.8'- loxy carbonylaminomethyl cyclohexanecarboxylic acid tetramethyl-6'-hydroxychroman, O 1-stearoyl-2- ammonium, trans-4-3-chlorobenzyloxy carbonylaminom palmitoylglycero-3-phospho-2'-hydroxymethyl-2',5'.7.8'- ethyl cyclohexanecarboxylic acid potassium, trans-4-3-bro US 2006/0165636 A1 Jul. 27, 2006

mobenzyloxy carbonylaminomethyl cyclohexanecarboxylic nositol linoleic acid, and astaxanthin acid potassium, trans-4-m-chlorobenzyloxy carbonylami glycerophosphatidylcholine linoleic acid, etc.); Steviol gly nomethyl cyclohexanecarboxylic acid calcium, trans-4-3- cosides; benzimidazole derivatives (1-(2-ethoxyethyl)-2-1- methoxybenzyloxy carbonylaminomethyl cyclohexanecar (2-(4-(1-(4,4-dimethyl-2-oxazolin-2-yl)-1-methylethyl)phe boxylic acid magnesium, trans-4-3-methylbenzyloxy nyl)ethyl)pyperidin-4-yl)-1H-benzimidazole, 2-4-(2-(4-(1- carbonylaminomethyl cyclohexanecarboxylic acid monoet (2-ethoxyethyl)benzimidazol-2-yl)pyperidin-1- hanolamine, trans-4-t-butyloxy carbonylaminomethyl yl)ethyl)phenyl-2-methyl propanoic acid, ethyl 2-4-(2-(4- cyclohexanecarboxylic acid, trans-4-(2-phenylisopropyloxy (1(2-ethoxyethyl)benzimidazol-2-yl)pyperidin-1- carbonylaminomethyl)cyclohexanecarboxylic acid, trans-4- yl)ethyl)phenyl-2-methyl propanoate, 1-(2-ethoxyethyl)-2- (p-biphenyl isopropyloxycarbonylaminom 1-(2-(4-(1,1-dimethyl-2- ethyl)cyclohxanecarboxylic acid, trans-4-(3,5-dimethox hydroxyethyl)phenyl)ethyl)pyperidin-4-yl)-1H yphenyl benzimidazol, 1-(2-hydroxyethyl)-2-1-(2-(4-(1-(4.4- isopropyloxycarbonylaminomethyl)cyclohexanecarboxylic dimethyl-oxazolin-2-yl)-1- acid, trans-4-(p-methylphenyl isopropyloxycarbonylami methylethyl)phenyl)ethyl)pyperidin-4-yl)-1H nomethyl)cyclohexanecarboxylic acid, trans-4-t-butyloxy benzimidazol, and 2-4-(2-(4-(1-(2- carbonylaminomethyl cyclohexanecarboxylic acid sodium, hydroxyethyl)benzimidazol-2-yl)pyperidin-1- trans-4-(2-phenylisopropyloxycarbony yl)ethyl)phenyl-2-methyl propanoic acid, etc.); alanine laminomethyl)cyclohxanecarboxylic acid potassium, trans derivatives or salts thereof (N-3-isopentyl-4-methyl-2-4- 4-(p-biphenylisopropyloxycarbony (3-trifluoromethylbenzamide)benzoylimino-3H-thiazoline laminomethyl)cyclohaxanecarboxylic acid calcium, trans-4- 5-carbonyl-L-alanine, N-3-isopentyl-4-methyl-2-4-(3- (3,5-dimethoxyphenylisopropyloxycarbonylaminomethyl trifluoromethylbenzamide)benzoylimino-3H-thiazoline-5- )cyclohxanecarbo Xylic acid magnesium, trans-4-(p-meth carbonyl-2-methylalanine, and N-3-isopentyl-4-methyl ylphenylisopropyloxycarbony 2-4-(3-trifluoromethylbenzamide)benzoylimino-3H laminomethyl)cyclohexanecarboxy lic acid monoethanola thiazoline-5-carbonyl-N-methyl-L-alanine, etc.); mine, trans-4-(9-fluorenylmethyloxycarbonylaminomethyl thiazoline derivatives or salts thereof (3-isopentyl-4-methyl )cyclohexanecarboxylic acid, trans-4-methylsulfonyl ethy 2-4-(3-trifluoromethylbenzamide)benzoylimino-3H-thia loxycarbonylaminomethyl cyclohexanecarboxylic acid, Zoline-5-carboxylic acid and 4-isobutyl-3-methyl-2-4-(3- trans-4-(9-fluorenylmethyloxycarbonylaminomethyl)cyclo trifluoromethylbenzamide)benzoylimino-3H-thiazoline-5- hexanecarboxylic acid sodium, trans-4-methylsulfonyl ethy carboxylic acid, etc.); chlorpheniramine maleate, loxycarbonylaminomethyl cyclohexanecarboxylic acid diphenhydramine hydrochloride, diphenylpyrarine potassium, trans-4-(pyridine-4'-methyloxycarbonylami hydrpchloride, carbinoxamine maleate, hydrocortisone nomethyl)cyclohexanecarboxylic acid, trans-4-(2.2.2- butyrate, Sulfated acidic mucopolysaccharides or salts trichloroethyloxycarbonylami thereof, and sulfated dextran or its salt. nomethyl)cyclohexanecarboxylic acid, trans-4-(2- 0054 Examples of the compound further include a chro trimethylsilylethoxycarbonylaminomethyl man derivative, pyridoxine or its salt and derivatives thereof, )cyclohexanecarboxylic acid potassium, trans-4-(pyridine pyridoxal or its salt and derivatives thereof, pyridoxamine or 41-methyloxycarbonylaminomethyl)cyclohexanecarboxylic its salt and derivatives thereof. Sulfur, calcium gluconate, acid sodium, trans-4-(2.2.2-trichloroethyloxycarbonylami chlorhexidine gluconate, Sulfamine, mercurochrome, lacto nomethyl)cyclohexanecarboxylic acid potassium, or trans ferrin or a hydrolysate thereof, alkyldiaminoethylglycine 4-(2-trimethylsilylethoxycarbony chloride solution, triclosan, Sodium hypochlorite, chloram laminomethyl)cyclohexanecarboxylic acid calcium; and ine T. bleaching powder, iodine compounds, iodoform, sulfatide. 1-alkyl carbapenem compounds, N-Substituted azepan 0053 Examples of the compound further include: astax derivatives or salts thereof, Sorbic acid or its salt, propionic anthin fatty acid diesters (astaxanthin dilauric ester, astax acid or its salt, Salicylic acid or its salt, dehydroacetic acid, anthin dimyristic ester, astaxanthin dipentadecanoate, astax parahydroxybenzoates, 2-keto-3-deoxyoctonate fatty acid anthin dipalmitate, astaxanthin dipalmitolenate, astaxanthin ester, deoxyinositol derivatives (quercitol etc.), inositol diheptadecanorate, astaxanthin dielaidate, astaxanthin dire unsaturated derivatives (conduritol etc.), inositol dimethyl cinolate, astaxanthin petroselinoate, astaxanthin vaccenoate, ether, dodecylglycerin ether, methyl inositol, inositol methyl astaxanthin eleostearate, astaxanthin punicin ester, astaxan ether, inosamine, deoxyinosadiamine, shikimic acid, quinic thin licanate, astaxanthin parinate, astaxanthin gadol acid acid, undecylenic acid, thiamine laurylsulfate, thiamine lau ester, astaxanthin 5-eicosenoic ester, astaxanthin 5-docose rylnitrate, phenol, cresol, p-chlorophenol, p-chloro-m-Xyle noic ester, astaxanthin cetolate, astaxanthin erucinate, astax nol, p-chloro-m-cresol, thymol, phenethyl alcohol, O-phe anthin 5,13-docosadiene ester, astaxanthin ceracol acid nylphenol, irgasan CH3565, halocarban, hexachlorophene, ester, astaxanthin decenoate, astaxanthin stering acid ester, chlorohexydine, ethanol, methanol, isopropyl alcohol, ben astaxanthin dodecenoate, astaxanthin dioleate, astaxanthin Zyl alcohol, ethylene glycol, propylene glycol, dipropylene distearate, astaxanthin dieicosapentaenoate, astaxanthin glycol, 2-phenoxyethanol, 1,3-butanediol, 3-methyl 1,3-bu didocosahexaenoate, astaxanthin dilinoleate, astaxanthin tanediol. 1.2-pentanediol, Zincpyridione, chlorobutanol, iso dilinolenate, and astaxanthin diarachidonate, etc.); astaxan propyl methylphenol, elemol, Vetiverol, patchouli alcohol, thin diglycerophosphates (astaxanthin diglycerophosphate, formaldehyde, hexamine, brilliant green, malachite green, astaxanthin glycerophosphoric acid palmitic acid, astaxan crystal violet, dermal, photopigment 101, photopigment thin glycerophosphatidylcholine palmitic acid, astaxanthin 201, photopigment 401, and an N-long-chain acyl basic glycerophosphatidylcholine DHA, astaxanthin glycerophos amino acid derivative and an acid addition salt thereof. phatidylinositol palmitic acid, astaxanthin glycerophos 0055 Examples of the compound further include cepha phatidylinositol DHA, astaxanthin glycerophosphatidyli ranthine, capronium chloride, eugenol derivatives (acetyl

US 2006/0165636 A1 Jul. 27, 2006

Zoate, 4-dodecyloxybenzoate, 4-(12-hydroxydodecyloxy mide, cerebroside, phosphatidylglucosylacylglycerol, )benzoate, 3-(12-hydroxyoctadecyloxy)benzoate, 4-(12-hy N-oleoylsphingosine, N-(12-hydroxyoctadecanoyl)sphin droxyoctadecyloxy)benzoate, 3-(11 gosine, N-(16-hydroxyhexadecanoyl)sphingosine, N-salicy hydroxyundecyloxy)benzoate, 4-(11 loyl phytosphingosine, sphingomyelin, soybean lecithin, hydroxyundecyloxy)benzoate, 3-(2E)-3,7-dimethyl-2,6- and egg-yolk lecithin, etc.), sterins (cholesterol, dihydroc octadienyloxybenzoate, 4-(2E)-3,7-dimethyl-2,6- holesterol, cholesteryl Stearate, hydroxycholesteryl Stearate, octadienyloxybenzoate, 3-(2E,6E)-3.7.11-trimethyl-2.6, macadamia nut oil cholesteryl fatty acid, B-sitosterol, Stig 10-dodecatrienyloxybenzoate, 4-(2E,6E)-3,7,11 masterol, campesterol, ergosterol, 5-dihydroergosterol, phy trimethyl-2,6,10-dodecatrienyloxybenzoate, 4-3,7- tosterol, 25-hydroxycholesterol, 26-hydroxycholesterol, dimethyl-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8- 19-hydroxycholesterol, 22-ketocholesteroloxime, 6-ketoc nonatetraenyloxybenzoate, 4-3,4-dihydro-2,5,7,8- holesterol, and 7-ketocholesterol or derivatives thereof, tetramethyl-2-(4.8, 12-trimethyltridecyl)-2H-1-benzopyran etc.), N-acetylneuraminic acid (sialic acid), N-glucosol 6-oxybenzoate, methyl parahydroxybenzoate, propyl neuraminic acid, gangliosides (galaose, ganglitriaose, gan parahydroxybenzoate, 4-(2E,6E)-3.7.11-trimethyl-2,6,10 glitetraose, globotetraose, neolactotetraose, neolacto dodecatrienyloxybenzamide, 4-(2E)-3,7-dimethyl-2,6- hexaose, and neolactooctaose, etc.), oligosulfated octadienyloxybenzamide, 4-(2-methyl-2-butenyloxy)ben hyaluronic acid, a hydroxytamoxifen compound, glycero Zamide, 4-(2-ethylhexcyloxy)benzamide, glycolipids, pentoxyferin, 3-deazaadenosine, a carboxya 4-dodecyloxybenzamide, 4-(12-hydroxydodecyloxy)benza mide derivative, inositolpolyamines, sialyl acid, a triterpenic mide, 4-(12-hydroxyoctadecyloxy)benzamide, 4-(11-hy acid derivative, lactose, a lactosamine derivative, a Sulfated droxyundecyloxy)benzamide, 4-(10-hydroxydecyloxy)ben chitin derivative, and albumin. Zamide, 4-isostearyloxybenzamide, N-(2-hydroxyethyl)-4- 0060) Examples of the compound further include a (2E,6E)-3,7,11-trimetyl-2,6,10 tropolone and its derivative, guanidine, ethanolamine, tri dodecatrienyloxylbenzamide, N,N-dimethyl-4-(2E,6E)-3, ethanolamine, aminoguanidine, flavanones (naringin, narin 7, 11-trimetyl-2,6,10-dodecatrienyloxybenzamide, N,N-di genin, maringin, maringenin, liquiritin, liquiritigenin, digallic (2E)-3,7-dimethyl-2,6-octadienyl-4-aminobenzamide, acid, luteic acid, ellagic acid, chlorogenic acid, glucogallin, 4-N'-methoxycarbonyl-N-(2E)-3,7-dimethyl-2,6-octadi tetralin, hamamelitannin, tannin gallate, tannic acid, gera enylaminobenzamide, 4-N-acetyl-N-(2E)-3,7-dimethyl-2, niin, gallic acid, galloyl gallic acid, ellagitannin, hexagal 6-octadienyl)aminobenzamide, N-(2-hydroxyethyl)-4-(2E, loylglucose, heptagalloylglucose, tetragalloylglucose, tri 6E)-3,7,11-trimethyl-2,6,10-dodecatrienyloxy-2- galloylglucose, pentagalloylglucose, digalloylquininic acid, hydroxybenzamide, and N,N-diethyl-4-(2E,6E)-3,7,11 and trigalloylquininic acid), a 2-hydroxyphenylalkylamine trimethyl-2,6,10-dodecatrienyloxy-2-hydroxybenzamide. derivative or its salt, phenylpropen derivatives (3-2,3-bis 0.058 Examples of the compound further include anac (methoxymethoxy)phenylpropenoate, 7-(4-hydroxy-3- ardic acid or its derivative (6-pentadecatrienyl salicylic methoxyphenyl)hepta-2,4,6-trienoic acid, 3-(3.5- methylether, 6-pentadecatrienyl salicylic ethylether, 6-pen dimethoxy-4-hydroxyphenyl)propenohydrazide, and tadecatrienyl salicylic propylether, 6-pentadecatrienyl sali N'-isopropylidene-3-(2-methoxyphenyl)propenohydrazide, cylic butylether, 6-pentadecatrienyl salicyl alcohol methyl etc.), Y-amino-3-hydroxybutyrates (methyl Y-amino-B-hy ether, 6-pentadecatrienyl salicyl alcohol ethyl ether, 6-pen droxybutyrate, ethyl Y-amino-B-hydroxybutyrate, propyl tadecatrienyl salicylalcohol propyl ether, 6-pentadecatrienyl y-amino-3-hydroxybutyrate, butyl Y-amino-B-hydroxybu salicyl alcohol butyl ether, 6-pentadecatrienyl salicylalde tyrate, ethylhexyl Y-amino-B-hydroxybutyrate, hexadecyl hyde methyl ether, 6-pentadecatrienyl salicylaldehyde ethyl y-amino-3-hydroxyhexabutyrate, lauryl Y-amino-B-hy ether, 6-pentadecatrienyl salicylaldehyde propyl ether, droxybutyrate, Stearyl Y-amino-B-hydroxybutyrate, oleyl 6-pentadecatrienyl salicylaldehyde butyl ether, 2-methyl y-amino-3-hydroxybutyrate, benzyl Y-amino-B-hydroxybu ether-6-pentadecatrienyl cinnamate, 2-ethylether-6-pentade tyrate, phenyl Y-amino-B-hydroxybutyrate, ethyl glycol catrienyl cinnamate, 2-propylether-6-pentadecatrienyl cin y-amino-3-hydroxybutyrate, Sorbitol Y-amino-B-hydroxybu namate, 2-butylether-6-pentadecatrienyl cinnamate, tyrate, polyoxyethyleneglycol Y-amino-B-hydroxybutyrate, 2-methylether-6-pentadecatrienyl cinnamic alcohol, 2-eth and glycerin Y-amino-B-hydroxybutyrate, etc.). ylether-6-pentadecatrienyl cinnamic alcohol. 2-propylether 0061 Examples of the compound further include: amin 6-pentadecatrienyl cinnamic alcohol, and 2-butylether-6- eoxides (oleyldimethylamineoxide, Stearyldimethylamin pentadecatrienyl, etc.), polyisoprenylated benzophenone eoxide, palmitylidimethylamineoxide, myristyldimethylami derivatives (garcinol, isogarcinol, Xanthochymol, isoxantho neoxide, lauryldimethylamineoxide, echymol, and guttiferone, etc.), a stilbene derivative or its dimethyllaurylethoxyamineoxide, dihydroxyethyllaurylami salt, morgin or its salt and derivatives thereof, and N-acetyl neoxide, and palm oil alkyldimethylamineoxide, etc.), alky glucosamine. 1betaines (palm oil fatty acid amide propylbetaine, palm oil 0059 Examples of the compound further include phos alkylbetaine, lauryldimethylaminobetaine acetate, lauric pholipids (phosphatidylethanol, phosphatidylcholine, phos acid amidopropylbetaine, laurylamidopropylbetaine, lauryl phatidyltriethanolamine, phosphatidylserine, phosphatidic hydroxysulfobetaine, 2-alkyl-N-carboxymethyl-N-hydroxy acid, phosphatidylglycerol, phosphatidylinositol, dia ethylimidazolynium betaine, and dodecylcarboxyethylhy cylphosphatidylcholine, diacylphosphatidylethanolamine, droxyethyl betaine, etc.), pyrimidine N-oxide derivatives diacylphosphatidylinositol, diacylphosphatidylserine, (2-amino-4-methyl-6-pyperidinopyrimidine-3-oxide, 1-cysteinylphosphatidic acid. 2-cysteinylphosphatidic acid, 2-amino-4-methyl-6-(1-pyrrolidinyl)pyrimidine-3-oxide, 1-glutathionylphosphatidic acid, 2-glutathionylphosphatidic 2-amino-4-methyl-6-morpholinopyrimidine-3-oxide, acid, 1-aZelaoylphosphatidic acid, 2-azelaoylphosphatidic 2-amino-4-methyl-6-1-(4-methylpiperazinyl)pyrimidine-3- acid, 1-hydroxyacylphosphatidic -acid, 2-hydroxyacylphos oxide, 2-amino-4-(1-hexahydroazepinyl)-6-methylpyrimi phatidic acid, ceramide, glucosylceramide, galactosylcera dine-1-oxide, 2-amino-4-dimethylamino-6-methylpyrimi US 2006/0165636 A1 Jul. 27, 2006

dine-1-oxide, 2-amino-4-allylamino-6-methylpyrimidine-1- metabolite; an extract of fungi, mushroom, or the like; an oxide, 2-amino-4-benzylamino-6-methylpyrimidine-1- actinomyceta extract; bacillus natto metabolite; bacillus oxide, 2-amino-4,5-methyl-6-pyperidinopyrimidine-3- natto extract; a Soya protein hydrolysate; a rice fermentative oxide, 2-amino-4-ethyl-6-morpholinopyrimidine-3-oxide, extract; rice bran (red bran and white bran) fermentative 2-amino-4-methyl-5-nitro-6-pyperidinopyrimidine-3-oxide, extracts; an euglena extract or its digest or soluble deriva 2,5-diamino-4-methyl-6-pyperidinopyrimidine-3-oxide, tives thereof; a lactic fermented product of raw milk or 2-amino-4-methyl-5,6-bis(1-pyrodinyl)pyrimidine-3-oxide, skimmilk powder; and trehalose, its derivative, and the like. 2-amino-4-methyl-5-pyperidino-6-(1-pyroridinyl)pyrimi 0064. Examples of the compound further include and dine-3-oxide, 2-methyl-4-amino-6-pyperidinopyrimidine-3- Substances from natural products such as oceanic component oxide, 2-methyl-4-amino-5-bromo-6-(1-pyrodinyl)pyrimi including: Salt waters such as deep water including sea water dine-3-oxide, 2-methyl-4-amino-5-nitro-6- salt; a sea water dry Substance; mineral salts obtained by sea pyperidinopyrimidine-3-oxide, 2-methyl-4,5-diamino-6- water of Dead Sea, Atlantic Ocean, or Pacific Ocean pyperidinopyrimidine-3-oxide, 2-methyl-4-amino-5,6- (sodium chloride, magunisium chloride, potassium chloride, bis(1-pyrodinyl)pyrimidine-3-oxide, 2-amino-4-methyl-6- and the like); sea muds or muds (fungos) such as sea muds pyperidinopyrimidine-3-oxide monohydrochloride, or muds (contained components: silicon dioxide, thitanium 2-acetylamino-4-methyl-6-pyperidinopyrimidine-3-oxide dioxide, alminum oxide, iron oxide, manganese oxide, monohydrochloride, 2,4-diamino-6-phenoxypyrimidine-3- Sodium oxide, pottadium oxide, magnesium oxide, calcium oxide, 2,4-diamino-6-(2,4-dichlorophenoxy)pyrimidine-3- oxide, strontium oxide, Sodium, potassium, magnesium, oxide, 2,4-diamino-6-(2,4,6-trichlorophenoxy)pyrimidine calcium, chrome, iron, copper, nickel, Zinc, lead, manga 3-oxide, 2,4-diamino-5-nitroso-6-(2,4- nese, arsenic, and water) Such as Italian fango, German dichlorophenoxy)pyrimidine-3-oxide, 2,4-diamino-5-nitro fango, Eifel fango, and Freiburg fango; shotokustone. 6-(2,4,6-trichlorophenoxy)pyrimidine-3-oxide, 2,4- diamino-5-nitro-6-(2,4-dichlorophenoxy)pyrimidine-3- 0065 Examples of the compound further include various oxide, 2,4,5-triamino-6-(2,4-dichlorophenoxy)pyrimidine compounds, extracts of animals, plants, and microorgan 3-oxide, and 2,4-diamino-5-bromo-6-(2,4- isms, naturally-derived from Substances, and the like Such as dichlorophenoxy)pyrimidine-3-oxide, etc.), p-menthane-3, almond extract, Phyllanthus emblica extract, ukyoyo 8-diol, monoglyceryl-D-glucoside monotridecanoate, 1-o- extract, Atractylodes ovata extract, Atractylodes japonica N-pentadecylglycero-D-glucoside, decylglycerylglucoside, extract, konfuyou extract, uncaria extract, gaigicya extract, ethylglucoside, eugenylglucoside, and glyceride Sulfate Such kakojuyo extract, glycyrrhiza extract, Gardenia florida as monopentadecanic acid glyceride Sulfate. extract, kuranigean extract, Sophora angustifolia extract, Scutellaria baicalensis root extract, triticum extract, rice 0062) Examples of the compound further include mono extract, coriaria extract, Sidowaya extract, Sanukyu extract, pentadecylglyceryl ether Sulfate, 1-o-hexadecyl-2-o-meth Sanbitro extract, Cassia minosoides extract, silane extract, ylglycerol, 1-o-octadecyl-2-o-methylglycerol, 1-o-oleyl-2- Cnidium officinale root extract, Senna leaf powdered extract, o-methylglycerol, acetylcarnitine O its salt, Inula britannica extract, Lynthrum anceps extract, Surigaten geranylgeranylacetone, a hydroxam derivative or its salt, a extract, Angelica decursiva extract, coix seed extract, rotun Zingerone glycoside, a benzene oxyacetate derivative (5- difolia extract, Vitex rotundifolia extract, Hamamelis vir 2-1-phenyl-1-(3-pyridyl)methylideneaminooxyethyl-7, giniana extract, palm extract, Parietaria officinalis extract, 8-dihydronaphthalen-1-yloxyacetate and the like), isorham safflower extract, Morus alba extract, Sophora flavescens netin-3-robinobioside, a Xanthone derivative, extract, irudaceas extract, Iris florentina extract, Clematis proanthocyanidins (proanthocyanidin from a grape seed terniflora extract, yasyajitu extract, hongkong extract, San extract, proanthocyanidin derived from apples, proanthocya guisorba officinalis root extract, yuzuriha extract, nidin derived from pine, purified proanthocyanidin oligo Polygonum multiflorum extract, fatsia extract, myall extract, mer, proanthocyanidin B-1, proanthocyanidin B-2, proan acerola extract, flowering maole extract, silver birch extract, thocyanidin B-3, and proanthocyanidin C-1, etc.), gallic extract, Paulownia tomentosa extract, Plectranthus phthalazinones, benzoxadinones, a phosphoate derivative, kameba extract, Isodon trichocarpus extract, Plectranthus cyproterone, 5C.-androstene-3C, 173-diol, medoroxyproges japonicus extract, Japanese parsley extract, buckwheat terone, norethisterone, and mestanolone. extract, dabiria extract, Capsella bursa-pastoris extract, 0063 Examples of the compound further include: a crista thoroughwort extract, camomile extract, mulberry extract, galli extract; a bovine, pork, or human placenta extract; pork Sophora angustifolia extract, felon herb extract, paper birch or bovine belly, duodenum, intestinal, kidney extracts or extract, houttuynia extract, hoelen extract, Lamium album digests thereof: a bovine or a pork brain extract; soluble extract, hop Vine extract, crataegus friut extract, Eucalyptus collagen; collagen derivatives Such as acylated collagen. globulus leaf extract, Althaea officinalis root extract, cinna collagen hydrolysates (tripeptide from collagen and the mon bark extract, Vitex ritundifolia extract, Hamameris like); elastin; an elastin hydrolysate; a soluble elastin deriva virginiana extract, Morus bombycis extract, platycodon root tive: keratin and its digest or derivatives thereof; a silk extract, cuscuta seed extract, Euphorbia lathyris extract, protein and its digest or derivatives thereof; a pork or bovine Belancanda chinensis extract, ephedra herba extract, Ara hemocyte protein digest (globin peptide); a bovine or pork liae cardatas rhizome extract, Saikokeishikankyoto dry hemoglobin digest (hemin, hematin, hem, protohem, and extract, Saposhnikovia divaricate extract, Glehnia littoralis hemoferrum, etc.); milk; casein and its digest (casein extract, Cortex moutan extract, Paeonia albiflora root hydrolysate and the like) or derivatives thereof; skimmilk extract, Geranium thunbergii extract, Radix puepariae powder and its digest or derivatives thereof; lactoferrin or its extract, licorice extract, praecox extract, aloe extract, Cimic digest; an egg component; a fish digest; a yeast metabolite; ifuga rhizome extract, green tea extract, black tea extract, a yeast extract; a bacteria metabolite; a bacteria extract; a gambir extract, anise extract, Polygonum cuspidatum metabolite of fungi, mushroom, or the like; an actinomyceta extract, Daphne pseudo-mezereum extract, Cassia obtusifo US 2006/0165636 A1 Jul. 27, 2006 16 lia extract, Cassiae semen extract, Astragali radix extract, loupia acuminata extract, Carpopeltis afflinis extract, Astragalus membranaceus extract, Trichosanthes bracteata Graciliaria gigas extract, Ceratodictyon spongiosum extract, extract, Xanthium stramarium extract, Gastrodia elata LOmentaria catenata extract, Lomentaria pinnata extract, extract, firethorn extract, Polygonum Sachalinense extract, LOmentania Okamurae extract, Laurencia intermedia Lindera Strychnifolia extract, pumpkin extract, Tipha lati extract, Laurencia undulata extract, Laurencia pinnata folia extract, Euphoribia kansui extract, Agrimonia pilosa extract, Laurencia brongniartii extract, Odonthalia corym extract, Lindera umbellata extract, Saxifraga fisca extract, bifera extract, thira extract, kamote de azafuran extract, sisal hemp extract, Clematis chinensis extract, Clematis jamaica extract, poreo Velde extract, nabo negro extract, chinensis extract, Clematis chinensis root extract, Prunus Zanthoxylum piperitum extract, Aralia cordata extract, speciosa extract, Prunus Sargentii extract, Prunus incisa Angelica pubescens extract, gasho extract, ever green oak extract, Prunus nipponia extract, Prunus Subhirtella extract, extract, Circaea cordata extract, Ageratum convzoides Prunus lannesiana extract, Aster tataricus extract, Trachy extract, Rumex japonicus root extract, Gymnema Sylvestre carpus fortunei extract, Iris florentina extract, Clematis extract, karoou extract, Tareana gracilipes extract, Mus terniflora extract, Magnolia salicifolia extract, Saxifraga saenda parviflora extract, Sabunryo extract, jasminum fortunei var. incisolobata extract, white evening primrose extract, Alcea rosea extract, shoraito extract, Arabidopsis extract, Cuscutae semen extract, Cuscuta australis extract, thaliana extract, Aspidistra elation, extract, Aconitum Cuscuta japonica extract, Artemisia absinthium extract, japonicum extract, Erythrina Cristagalli extract, AuCommia Achillea alpina extract, Dictamnus dasyCarpus extract, dill ulmoides extract, Ruscus aculeatus (Butcher's broom) seed extract, Polygonum cuspidatum extract, Tribulus ter extract, Ecballium elaterium extract, Loropetalum chinense restris extract, Mimachlamys nobilis extract, Pyrrosia lin extract, Sapium sebiferum extract, Ailanthus moluccana gua extract, Tipha angustifolia extract, Angelica dahurica extract, Dianthus hybridus extract, Polygonum cuspidatum extract, floral blanca extract, hamyura extract, Artemisia extract, Polygonum aviculare extract, Corchorus Olitorius priceps extract, Convolvulus arvensis extract, Santalum extract, Salix subfragilis extract, Salix babylonica extract, album extract, Ganoderma lucidum extract, Leonurus Sibiri Kummerowia striata extract, Coronilla varia extract, Wik cus extract, Salix gilgiana extract, Salix chaenomeloides stroemia indica extract, Dictyota dichotoma extract, shell extract, Salix gracilistyla extract, Salix integra extract, Salix fishes extract (a cockles extract, Perna viridis extract, oyster kinuyanagi extract, Salix kOriyanagai extract, Salix mat extract, Ostrea edulis extract, Scallop extract, clam extract, Sudana extract, Salix reinii extract, Salix Sieboldiana extract, clam extract, mactridae extract, Nuttalia olivacea extract, Toisusu urbaniana extract, Salix Schwernii extract, Salix ark shell extract, shell fish extract, top shell extract, Baby vulpina extract, Populus maximowiczii extract, Myrica lonia japonica extract, and the like), Aucuba japonica rubra extract, Agave americana extract, Agave americana extract, bottle tree extract, Firmiana sp. extract, Astilbe Var. marginata extract, Agave americana Var. marginata thunbergii extract, Trifolium pratense extract, Thalictrum extract, Edgeworthia chrysantha extract, Enteromorpha sp. rminus extract, Aguaje (Mauritia flexuosa) extract, Pharbitis extract, Enteromorpha linza extract, Enteromorpha prolifera purpurea extract, morning glory extract, Canna edulis extract, Enteromorpha compressa extract, Enteromorpha extract, oilseed rape extract, Gynostemma pentaphyllum intestinalis extract, Enteromorpha Crinita extract, Lami extract, Tulipa edulis extract, Amaranthus extract, Amaran naria sp. extract, Laminaria japonica extract, Laminaria thus tricolor extract, Amaranthus caudatus extract, Velvet Ochotensis extract, Laminaria religiosa extract, Laminaria flower extract, Amaranthus cruentus extract, Amaranthus angustata extract. Undaria pinnatifida extract, Undaria patulus extract, beetroot extract, spiny pigweed extract, undaroides extract, Undaria peterseniana extract, Hizikia Epipactis papillosa extract, Amaranthus hypocondriacus fiusiformis extract, Fucus evanescens extract, Padina arbore extract, Alstroemeria extract, alcanna extract, Algarrobo scens extract, Padina australis extract, kirebanoumiuchiwa extract, Aloe barbadensis extract, igusa reed extract, yew extract, Padina boryana extract, Padina crassa extract, extract, Strawberry extract, locust bean extract, draba Padina japonica extract, Padina minor extract, Padina extract, rice extract, catmint extract, Conandron extract, stipitata extract, Eucheuma serra extract, Eucheuma amaku Selaginella extract, Selaginella tamariscina extract, wheat saense extract, Eucheuma denticulatum extract, Eucheuma (Genipa americana) extract, floating grass extract, extract, armoldii extract, Chondrous ocellatus extract, Chondrus marshmallow extract, mallow extract, Cat's Claw (Uncaria verrucosus extract, Chondrus nipponicus extract, Chondrus tomentosa) extract, winter mushroom extract, eryngii pinnulatus extract, Chondracanthus tenellus extract, Chon extract, Pleurotus eryngii extract, Opuntia maxima extract, dracanthus teedii extract, Chondracanthus intermedius Inula helenium extract, Eriocaulon extract, Oca extract, extract, Dictyopteris latiuscula extract, Dictyopteris poly Cnidium monnieri extract, okra extract, Dioscorea tokoro podioides extract, Padina arborescens extract, Nemacystus extract, tokoro extract, nagadokoro extract, ononis extract, decipiens extract, Sphaerotrichia divaricata extract, olluquito extract, Glechoma extract, Glechoma hederacea Cymathaera sp. extract, Cymathaere japonica extract, Sar extract, Hydrangea macrophylla extract, cascara Sagrada gassum hemiphyllum extract, Sargassum segi extract, Sar extract, gypsophila extract, asian ginseng extract, canihua gassum hemiphyllum extract, Sargassum sagamianum extract, carnation extract, gerbera extract, camu camu (camo extract, Saraggsum nigrifolium extract, Sargassum ring camo) extract, calla extract, oat extract, Chinese quince goldianum extract, Sargassum tosaense extract, Sargassum extract, Potentilla chinensis extract, Veronica undulata piluliferum extract, Sargassum thunbergii extract, Sargas extract, Dianthus superbus var. longicalycinus extract, sum ringgolodianum extract, Sargassum confilsum extract, Dianthus superbus var. longicalycinus extract, kantaraasa Sargassum multicum extract, Sargassum siliguastrum extract, Dendranthema boreale extract, quinua (quinoa) extract, Sargassum micracanthum extract, Sargassum extract, cabbage extract, kiwi extract, cucumber extract, giganteifolium extract, Grateloupia imbricata extract, Seb tamarisk extract, Ajuga decumbens extract, Parthenium denia flabellata extract, Sebdenia polydacty extract, Grate argentatum extract, Asparagus Cochinchinensis extract, US 2006/0165636 A1 Jul. 27, 2006 17 kudzu extract, Artemisia annua extract, cupuacu extract, extract, minisasanishiki extract, Chlorella vulgaris extract, Thlaspi arvense extract, Hovenia extract, selenicereus Chlorella pyrenoidsa extract, Chlorella elypsoidia extract, extract, Picrorrhiza kurrooa extract, coconut extract, cos Macrocystis pyrifera extract, Acanthopeltis extract, Meris mos extract, Clematis apifolia extract, rice oil extract, totheca papulosa extract, Gielidium japonicum extract, Por konjak extract, Saffron extract, sapodilla extract, Sangre de phyra extract, spirogyra extract, Prasiola extract, spherical grado (Cronton) extract, Panax notoginseng extract, Shea moss extract, Kornmannia extract, Dictyopteris divaricata (karete) extract, parkii extract, Shiitake mushroom extract, extract, Petalonia binghamiae extract, Petalonia fascia shimeji mushroom extract, hinshimeji extract, Lyophyllum extract, Colpomenia bullosa extract, Agarum extract, Cos filmosum extract, Lyophyllum decastes extract, Lyophyllum taria extract, Kjellmaniella extract, Eckloniopsis extract, connatum extract, Hypsizygus extract, Lyophyllum Shimei Ecklonia stolonifera extract, Hedophyllum extract, Arthroth extract, Lyophyllum marmoreus extract, Magnolia quin amnus extract, Alaria praelonga extract, Alaria crassifolia quepeta extract, Asarum extract, cactus extract, Ophiopogon extract, Silvetia babingtonii extract, Hormophysa cuneifor japonicus extract, Gypsophila paniculata extract, Dichroa mis extract, Turbinaria conoides extract, Cystoseira hako febrifuga extract, Sesbania grandiflora extract, Vigna datensis extract, Miyagropsis myagroides extract, Miyagrop extract, daphne extract, watermelon extract, Cynanchum sis turneri extract, Sargassum nipponicum extract, paniculatum extract, Portulacea extract, Dendrobium Sargassum fulvellum extract, Coccophora langsdorfii extract, Dendrobium linawianum extract, Dendrobium extract, Bangia atropurpurea extract, Porphyra yezoensis nobile extract, oobana Sekkoku extract, Dendrobium Okina extract, Trichogloea lubrica extract, Nemalion vermiculare wense extract, Dendrobium officinale extract, Dendrobium extract, Scinaia Okamurae extract, Portieria hornemannii phalaenopsis extract, shikaku Sekkoku extract, Dendrobium extract, Gloiopeltis complanata extract, Glolosiphonia cap tosaense extract, cedron (lemon verbena) extract, Malva illaris extract, Bonnemaisonia hamifera extract, Solieria Sylvestris extract, celery extract, Andrographis paniculata pacifica extract, Solieria tenuis extract, Meristotheca coacta extract, Oriental radish extract, Eclipta extract, Dioscorea extract, Turnerella mertensiana extract, Hypnea charoides gracillima extract, dahlia extract, tarwi extract, Euphorbia extract, Hypnea japonica extract, Hypnea saidana extract, extract, Atractylodis lanceae extract, chancapiedra (Phyl Hypnea variabilis extract, Gracilaria ermiculophylla lanthus amarus) extract, tulip extract, Chinese artichoke extract, Graciliaria chorda extract, Gielidiopsis hachijoensis extract, common mushroom extract, camellia extract, trefoil extract, Ahnfeltiopsis flabelliformis extract, Mazzaella extract, Dipsacus extract, corn extract, corn floss extract, japonica extract, sponge cucumber water, birch or red pine horsetail extract, Fraxinus extract, Prairie gentian extract, Sap. Rehmannia glutinosa var. purpurea extract, fennel Sword bean extract, Canavalia gladiate extract, jujube extract, Acanthopanax senticosus extract, barley extract, extract, Dipsacus japonicus extract, nameko extract, Boeh Echinops latifolius extract, Hypericum perforatum var. meria extract, Sweet violet extract, Myristica extract, silk angustifolium extract, Hypericum perforatum extract, pars tree extract, neb extract, nebi extract, Albizia julibrissn ley extract, celery extract, Rehmannia glutinosa extract, extract, Amaryllis extract, Celosia argentea extract, Genti roman chamonmile extract, Garcinia extract, Artemisia ana extract, Acer japonicum extract, Lupinus perennis apiacea extract, Epipactis thunbergii extract, Ouillaia extract, papaya eXtract, paharobobo extract, fiddle leaf fig extract, Cephalanthera falcata extract, Cephalanthera extract, field mushroom extract, field mushroom extract, erecta extract, Calendula officinalis extract, Neottia nidus horse mushroom extract, Agaricus abruptibulbus extract, avis var. mandshurica extract, Cephalanthera longibrac aspidistra extract, pariurusu (Paliurus ramosissimus) teata extract, Pterocarya rhoifolia extract, Filipendula mul extract, balsamina (Momordica charantia) extract, Gentiana tijuga extract, Glehnia littoralis extract, Prunus Salicina Thunbergii extract, Handaikai extract, Dahlia coccinea extract, walnut extract, pineapple extract, Orchis aristata extract, beet extract, hiba extract, sunflower extract, bell extract, Belancanda chinensis extract, Fagus crenata pepper extract, Aquilegia extract, Agaricus blazei extract, extract, Chinese lantern plant extract, Grifola frondosa Cordyceps sinensis extract, Periandra dulcis extract, hazel extract, loose strife extract, Hibiscus Syriacus extract, Sap nut extract, Sponge cucumber extract, crassulaceae extract, indus mukurossi extract, bean sprout extract, eucalyptus Sedum alboroseum extract, cotton bush extract, Kochia extract, meadow Saxifrage extract, Rubus suavissimus scoparia extract, Kochia scoparia extract, Kochia scoparia/ extract, lettuce extract, tanka bean extract, Gentiana extract, Kochia extract, garden balsam extract, Stellaria dichotoma burdock extract, Lithospermum erythrorhizon extract, carrot extract, Sedum aizoon extract, jojoba extract, borage extract, extract, Hammamelis extract, hop extract, Coix lachryma bordeaux extract, Cistanche extract, Dendrobium officinale jobi extract, Lamium album var. barbatum extract, Swertia extract, maca extract, macadamia nut extract, marguerite japonica extract, Thymus vulgaris extract, parsely extract, extract, Tropaeolum extract, Tropaeolum tuberosum extract, Pachydictyon Coriaceum extract, Dilophus Okamurae silver vine extract, pine corn extract, Poria Cocos extract, extract, gatugatakonbu extract, Laminaria longipedalis Buddleja globosa extract, oblonga extract, mullein (Verbas extract, Laminaria diabolica extract, Laminaria yezoensis cum thapsus) extract, manthanya (Andes camomile) extract, extract, Laminaria longissima extract, Laminaria vendoana Ottelia extract, Ottelia alismoides extract, Mentha viridis extract, oochijimikonbu extract, Tricleocarpa cylindrica extract, Strawflower extract, munya extract, Callicarpa extract, Galaxaura falcata extract, Helminthocladia austra extract, Callicarpa japonica extract, Milletia reticulata lis extract, Helminthocladia vendoana extract, kagekinori extract, moje (pepper tree) extract, holly extract, cornflower extract, Cirrulicarpus gmelini extract, Graciliaria bursa extract, yacon extract, palm tree extract, Carpesium extract, pastoris extract, Gracilaria textorii extract, Akebia quinata Horse chesnut extract, Chaenomeles lagenaria extract, lily extract, Hydrangea serrata var. thunbergii extract, oolong extract, Polyporus my littae extract, lime extract, rye extract, tea extract, Psoralea corylifolia extract, Cymbidium kanran shallot extract, eschalot extract, apple extract, gentian extract, Fortunella japonica extract, Rhus chinensis extract, extract, lychee extract, milk vetch extract, Coicis Semen Gen-no-shoko extract, Sasame extract, Sesame cultured cell US 2006/0165636 A1 Jul. 27, 2006

extract, Scrophularia buergeriana extract, rice bran extract, ulina extract, Trichodesmium extract, hunorinoushike pomegranate extract, Zanthoxylum piperitum extract, Pyrus extract, Gielidium divarivcatum extract, Gelidium pussillum communis extract, Rheum palmatum extract, tomate extract, extract, Gelidium pacificum extract, Porphyridium cruentum nandina extract, Cirsium japonicum extract, Rosa multiflora extract, red grape extract, adzuki extract, althea extract, extract, paprika extract, pistachio extract, Japanese medlar nettle extract, cascarilla extract, ceiba extract, guarana extract, betel extract, Petasites japonicus extract, Chaenom extract, Rubus idaeus var.aculeatissimus extract, Strawberry eles speciosa extract, linula linariifolia extract, ephedra extract, Rubus phoenicolasius extract, Rubus parvifolius extract, mimosa extract, Ocimum basilicum extract, hime extract, Rubus palmatus extract, raspberry extract, Aloe kumayanagi extract, Polygonum hydropiper extract, arborescens extract, Crataegus sp. extract, Melissa offici watahujiutsugi extract, Chlamydomonas sp. extract, nalis extract, cranberry extract, Cola bella extract, Sugar akayukimo. extract, Padina Crassa extract, Padina japonica cane extract, Shinahonoki extract, Lonicera japonica extract, extract, hammamelis extract, clove extract, melissa extract, Equisetum arvense extract, Larix Occidentalis extract, Sam Isodon japonicus extract, white birch extract, gingko extract, bucus migra (elder) extract, dandelion extract, Centaurium clove extract, Haematoxylon campechianum (logwood) extract, Taraxacum albidum extract, Taraxacum platycar extract, Mallotus japonicus extract, akaminoakane extract, pum extract, black gram extract, Galeola altissima extract, Rubia tinctorum extract, Rubia tinctorum extract, hydrangea Juglans regia var. orientis extract, tormentila extract, Rosa extract, Quercus variabills extract, fig extract, gingko multiflora extract, Casuarina equisetifolia extract, Lady's extract, asparagus extract, Prunus mume extract, Quercus Mantle extract, castor extract, grape extract (grape leaf Stenophylla extract, Arctostaphylos uva-ursi (bear-berry) extract), prune extract, Veronica extract, Visnaga extract, extract, estragon extract, Sophora japonica extract, Quercus bilberry extract, Juglans mandshurica extract, buckbean dentate extract, Inula salicina var. asiatica extract, birch extract, myrrh extract, hamamelis extract, Populus maxi extract, Betula extract, Quercus acutissima extract, Nerium mowiczii extract, rhatany (krameria) extract, lemon extract, indicum extract, Citrus kinokuni (Citrus leiocarpa, Citrus corn poppy extract, shikon extract, rose fruit extract, pro tachibana, Citrus tangerina, Citrus tumida, Sagamikoji, polis extract, polygonum tinctorium extract, Gambir extract, Citrus reticulata) extract, Santalum extract, coffee extract, avocado extract, Solomon's seal extract, Fritillaria verticil comfrey extract, bamboo extract, perilla extract, Perilla lata extract, Fritillaria extract, Elephantopus extract, frutescens extract, Perilla frutescens var. crispa extract, adders-wort extract, turmeric extract, echinacea (E. angus Perilla frutescens f. discolor extract, Paeonia lactiflora tifolia) extract, Coptidis japonica extract, inula britannica extract, Quercus serrata extract, Quercus Crispula extract, extract, Hypericum extract, Juglans mandshurica var. Sie Lagerstroemia indica extract, Lycium chinense extract, boldiana extract, orange extract, cassia extract, tetrapanax Quercus myrsinaefolia extract, Trifolium repens (clover) papyriferus extract, Agastache rugosa extract, Artemisia extract, horseradish extract, Farfugium japonicum extract, capillaris extract, water cress extract, Smilax glabra extract, tentya extract, Lindera Strychnifolia extract, Rosa laevigata gentiana extract, Dendrobium extract, ligusticum extract, extract, Arachis hypogea (peanut) extract, Cinnamomum Alipinia officinarum extract, Rubus chingii extract, Cremas extract, Cinnamomum okinawense extract, Cinnamomum tra appendiculata extract, cherry extract, Salvia (sage) zeylanicum extract, Cinnamomum japonicum (bark) extract, extract, digitalis extract. Thilia japonica extract, Sal tree cinnamon stick extract, Campsis grandiflora extract, lotus extract, ficus religiosa extract, Amomi Semen extract, Coix extract, napav extract, rye extract, Anemarrhena asphode lacryma jobi extract, Nandina domestica extract, ground ivy loides extract, Rosa rugosa extract, rose extract, barbasco extract, medowsweet extract, yarrow (milfoil) extract, extract, spinach extract, Fagus grandifolia extract (beech Polygala Senega extract, Echinops griisi extract, Scythian acrospire extract or the like), Fagus japonica extract, Fagus lamb extract, Thymus vulgaris extract, Stephania cepharan sylvatica extract, Calystegia japonica extract, hoSobanaok tha extract, Persicae Semen extract, Imperata extract, Ben era extract, Paeonia suffruticaoa extract, marjoram extract, incasa extract, Houttuynia cordata extract, parsley melon extract, Oenothera extract, Spiraea thunbergii (Petroselinum crispum) extract, Eschscholtzia extract, extract, orchid extract, Momordica grosvenori extract, rooi Cyperus rotundus extract, Chinese water chestnut extract, bos extract, Portieria japonica extract, Plocamium telfairiae Althea officinalis extract, Piper extract, Phaseolus radiatus extract, Plocamium telfairiae extract, Betula grossa extract, extract, Sandalwood extract, butchers broom extract, pansy basil extract, Saussureae extract, Cocculus trilobus extract, extract, Chrysanthemum indicum extract, Arisaema hetero thistle extract, Breea Segetum extract, Cirsium borealinip phyllum extract, Aurantii Fructus Immaturus extract, ponense extract, Cirsium maritinum extract, Cirsium japoni miracle fruit extract, Aphananthe aspera extract, peach cum extract, oobana-azami extract, cacao extract, Hercam extract, cornflower extract, Sweet gale extract, mistletoe puri extract, Sinomenium acutum extract, Curcuma Zedoaria extract, Ardisia japonica extract, Sagebrush extract, mug extract, Fumaria officinalis extract, Campanula punctata wort extract, rosemary extract, Polygala tenuifolia extract, extract, Hedera rhombea extract, pepper extract, Cola Chaetomorpha spiralis extract, Chaetomorpha moniligera acuminata extract, Alisma plantago-aquatica var. Orientale extract, Chaetomorpha Okamurai extract, Desnarestia ligu extract, shaddock extract, Cornus officinalis extract, Sinome lata extract, Desnarestia viridis extract, Mvelophycus sim nium acutum extract, Dendropolyporus umbellatus extract, plex extract, Sargassum horneri extract, Sargassum micra Centella aiatica extract, Gelidium extract, Gentiana scabre canthum extract, Neodilsea vendoana extract, Neodilsea extract, Gentiana scabre var. Scabra extract extract, Elsholt tenuipes extract, Ahnfeltiopsis paradoxa extract, Palmaria Zia ciliata extract, banana extract, Puer tea extract, plum palmata extract, Chondria crassicaulis extract, belladonna extract, bohu extract, benzoin extract, habu extract, Cla extract, Magnolia obovata extract, elm extract, hemp dophora japonica extract, Cladophora Sakai extract, Cla extract, dead nettle extract, watercress (cress) extract, Vale dophora glomerata extract, Peniophora quercina extract, rian extract, clematis extract, cumaceba extract, Saponaria Nostoc commune extract, Nostoc flagelliforme extract, Spir extract, rosewood extract, horse Chestnut extract, soybean US 2006/0165636 A1 Jul. 27, 2006 19

(Saponin) extract (for example, soybean seed extract), Cal linden extract, melilot extract, Citrus junos extract, Chimo endula officinalis (common marigold) extract, Chinese yam nanthus praecox extract, Ostericum sieboldii extract, hibis extract, Japanese yam extract, nasturtium extract, coltsfoot cus extract, rosehip extract, Gentiana extract, Thymus extract, Cayratia japonica extract, giant kelp extract, Cyr serpyllum subsp. quinquecostatus extract, Prunella vulgaris tymenia sparsa extract, Sophorae Radix extract, Ferula extract, Lagerstroemia speciosa (banaba) extract, Chinese (Agi) extract, Hiba arborvitae extract, alpinia extract, hawthorn extract, Crataegus cuneata extract, Magnolia offi Alpinia katsumadai extract, Amaranthus lividus (Amaran cinalis extract, guava extract, Schisandrae fructus extract, thus viridis) extract, Amaranthus retroflexus extract, Ama Plantago asiatica extract, Rosa centifolia extract, Hyperi ranthus spinosus extract, Amaranthus tricolor subsp. man cum perforatum extract, Stellaria extract, Achyranthes fau gostanus extract, Amaranthus tricolor extract, hoSonagabiyu riei extract, Magnolia obovata extract, fox grape extract, extract, Isodon japonicus extract, Lonicera gracilipes European grape extract, vitis coignetiae extract, madarin extract, Asarum sieboldii extract, Asarum europaeum extract, Bupleurum scorzoneraefolium extract, Pisum sati extract, Ulmus laciniata extract, Patrinia scabiosaefolia vum extract, Callophyllis extract, Mastocarpus vendoi extract, Uncaria rhynchophylla extract, Zanthoxylum pip extract, Gigartina Ochotensis extract, Mastocarpus pacifi eritum extract, camomile extract, Cinchona extract, Cin cus extract, Ceramium kondoi extract, Ceramium tenerri chona succirubra extract, Phellodendron bark extract, cara mum extract, Ceramium paniculatum extract, Ceramium way extract, Piper betle extract, Sasa veitchii extract, japonicum extract, Champia expansa extract, Polysiphonia cranberry extract, grapefruit extract, Celosia cristata extract, morrowii extract, Polysiphonia crassa extract, Chondria bay extract, Rosa chinensis extract, copaiba balsam extract, armata extract, Chondria dasyphylla extract, Chondria Prunus jamasakura extract, Prunus pendula extract, Prunus intertexta extract, Chondria ryukyuensis extract, Chondria maximowiczii extract, Prunus yedoensis extract, Prunus expansa extract, Chondria lancifolia extract, Wasabia verecunda extract, Prunus x kanzakura extract, Sugarbeet japonica extract, Epimedium grandiflorum extract, Epime extract, Cimicifuga. Simplex extract, Quisqualis indica dium grandiflorum var. grandiflorum (E. sagittatum) extract, extract, cinnamon extract, Rumex acetosa extract, Taraxacus Polygonatum falcatum extract, Polygonatum Sibiricum officinale extract, Juniperus communis extract, Mentha pip (root) extract, oregano extract, Dryopteris extract, Polygala erita extract, Melissa officinalis extract, Amomum tsao-ko root extract, prunus bark extract, Pinelia ternata extract, extract, onion extract, chicory extract, Ulmus macrocarpa Citrus aurantium extract, Lycium chinense extract, Evodia (fruit) extract, Tetragonia tetragonoides extract, Cephaelis rutaecarpa extract, Senega extract, Melia azedarach extract, extract, Allium tuberosum (Allium seed) extract, Allium tamarind extract, tarragon extract, Rheum Coreanum extract, fistuiosum extract, Prunus davidiana extract, patchouli Phyllostachys migra var. henonis extract, daisy extract, extract, Lycoris radiata extract, Japanese cypress extract, myrobalan extract, Hibiscussyriacus extract, laurel extract, pimenta extract, Pulsatilla chinensis extract, blackberry Cyrtonium fortunei extract, Ulva pertusa extract, Macro extract, Digenea simplex extract, Magnolia sprengeri cystis integrifolia extract, neocystis ruetokeana extract, extract, Lobelia chinensis extract, Cryptotaenia japonica Ptilophora subcostata extract, Pterocladia capillacea extract, Lithospermum erythrorhizon (root) extract, Phyl extract, Pterocladia capillacea extract, Acanthopeltis hir lostachys pubescens extract, Phytolacca (root) extract, suta extract, Gellidiella acerosa extract, Chondrus vendoi yucca extract, Angelica dahurica extract, lavender extract, extract, Chondrus armatus extract, Caulerpa Okamurae Forsythia suspensa extract, Forsythia viridissima extract, extract, Bryopsis plumosa extract, Codium fragile extract, Chondrus giganteus extract, Chondrus crispus extract, aka Codium divaricatum extract, Codium contractum extract, momijinori extract, Ulva pertusa extract, Monostroma initi Codium cylindricum extract, Codium latum extract, Cerato dum extract, Monostroma latissimum extract, Monostroma phyllum demersum extract, Cladosiphono Okamuranus Sravillei extract, Ishige sinicola extract, Ishige Okamurae extract, Nemacystus decipiens extract, Colpomenia sinuosa extract, Eisenia bicyclis extract, Delisea japonica extract, extract, Ecklonia cava extract, Gloiopeltis fircata extract, Grateloupia elliptica extract, Grateloupia divaricata Gloiopeltis tenax extract, linum extract, Broussonetia papy extract, Grateloupia imbricata extract, Neorhodomela rifera (fruit) extract, Broussonetia kazinokim extract, Orig aculeata extract, Batrachospermum irionoteensis extract, anum vulgaris extract, Artcarpus altilis extract, Chondrus Batrachospermum Sirodotii extract, Batrachospermum gal pinnulatus extract, Chondrus elatus extract, Ulva reticulata laei extract, Alpinia Oxyphylla extract, Angelica keiskei extract, Ulva arasaki extract, Callophyllis japonica extract, extract, arnica extract, Scirpus fluviatilis extract, Carum Callophyllis Crispata extract, Callophyllis palmata extract, carvi extract, Citrus unshiu (peel) extract, Corylus hetero Callophyllis adhaerens extract, Callophyllis adnata extract, phylla extract, Disopyros Kaki extract, Cinchona extract, Callophyllis rhynchocarpa extract, Callophyllis havamensis Cymbidium pumilum extract, Verbena officinalis extract, extract, Callophyllis imageshimensis extract, Callophyllis Papaver rhoeas extract, Nuphar japonicum extract, Arctium rhynchocarpa extract, Panax japonicus extract, Lilium lan lappa extract, Lobelia sessiflora extract, Forsythia viridis cifolium extract, Lilium japonicum extract, Lilium brownii sima extract, ginger extract, Acorus (calamus) extract, haw extract, corn poppy extract, Trichosanthes kirillowii var. thorn extract, Swertia japonica extract, Citrus aurantium japonica (Karokon) extract, fenugreek extract, Lablab pur (peel) extract, Salvia militiorrhiza extract, thyme extract, purea extract, lentil extract, Chick pea extract, mung-bean Panax japonicus extract, Polygonum multiflorum (tuberous extract, Arnica unalaschkensis var. tschonoskyi extract, root) extract, Codonopsis lanceolata extract, capsium Humulus japonicus extract, Humulus lupulus var. cordifo extract, Angelica extract, Ligustrum lucidum extract, Citrus lius extract, raspberry extract, Acorus gramineus (root) natsudaidai extract, Sambucus sieboldiana extract, Corylus extract, Quercus glauca extract, angelica extract, Prunus heteophylla extract, Scopolia japonica (root) extract, Men armeniaca var. ansu (apricot kernel) extract, Prunus arme tha arvensis extract, Glehnia littoralis extract, Echinops niaca extract, Pyrola japonica extract, Cytisus scoparius setifer extract, Daphne genkwa extract, blackcurrant extract, extract, Plantago asiatica extract, Alnus Sieboldiana extract, US 2006/0165636 A1 Jul. 27, 2006 20 olive extract, Veronica persica extract, Polygonatum extract, ayumato extract, huckleberry extract, batata extract, Epipac Trichosanthes cucumeroides extract, Trichosanthes kirillowi tis papillosa var. Sayekiana extract, barata extract, Cyn extract, Chrysanthemum extract, Chrysanthemum indicum bidium x nishiuchianum extract, pecannut extract, extract, Chrysanthemum zawadskii var. latilobum extract, hinachiyodori extract, Neottia asiatica extract, Pfaffia ires Catalpa Ovata extract, kukui nut extract, Cinnamomum cam inoudes extract, brahnen extract, Furcellaria extract, blond phora extract, cubeb extract, Rhamnus japonica var. decipi psyllium extract, Cymbidium dayanum extract, henequen ens extract, Schizonepetae extract, Osmanthus fragrams var. extract, berry extract, persea extract, peruvianberg extract, aurantiacus extract, Antirrhinum majus extract, Citrus Pereskia grandifolia extract, boysen berry extract, Cyn tachibana peel extract, Cameliaxhiennalis extract, coentro bidium sinense extract, Pouteria Sapota extract, Pouteria extract, Magnolia kobus extract, Magnolia liliflora extract, lucuma extract, Echinacea angustifolia extract, whortle Kadsura japonica extract, Kadsura japonica extract, berry extract, masaranduba extract, masaranduba do sealar Schisandra nigra extract, colombo extract, condurango extract, masheila de boi extract, matta orro extract, mulberry extract, Camellia Sasanqua extract, Sweet potato extract, extract, green Sapote extract, purple corn extract, Opuntia Zizyphus jujuba extract, Euchresta japonica (root) extract, megacantha extract, Pereskia aculeata extract, Rheum pal potato extract, Blechnum niponicum extract, Gardeniae matum extract, morello cherry extract, yawaraka-mu Fructus fruit extract, coriander extract, Stevia extract, rasakiimo extract, Monarda didyma extract, Echinops ritro Euphorbia pekihensis extract, Ilex latifolia extract, Aralia extract, red currant extract, red pitaya extract, lemongrass elata extract, Picrasma quassioides extract, Rhus javanica extract, Copernicia cerifera extract, logan berry extract, var. roxburghii (fruit) extract, Drynaria fortunei (root) green algae extracts such as Dunariella sp. (genus Dunari extract, Magnolia heptapeta extract, Iris florentina extract, ella) extract, Chlorococcus sp. (genus Chlorococcus) Dryopteris nipponensis extract, Gnaphalium affine extract, extract, Pandorina sp. (genus Pandorina) extract, Volvox Codonopsis pilosula (root) extract, mangosteen extract, Zin globator (genus Volvox) extract, Volvox sp. (genus Volvox) giber mioga extract, Melaleuca alternifolia extract, Alnus extract, Palmera extract, Tetraspora extract, Mougeotia firma extract, Alnus pendula extract, Alnus Sieboldiana (genus Spirogyra) extract, Draparnaldia plumosa extract, extract, Leonurus Sibiricus extract, Alnus hirsuta var. Ulothrix implexia (genus Ulothrix) extract, furicchera Sibirica extract, longan extract, Phragmites communis extract, Valonia macrophysa (genus Valonia) extract, Valo extract, logwood extract, lantana extract, Iris tectorum nia aegagropila (genus Valonia) extract, Boergesenia forbe extract, Polygoni Multiflori extract, kanto extract, Tulipa sii (genus Boergesenia) extract, Caulerpa recemosa (genus edulis extract, Gracilaria bursa-pastoris extract, Atractylo Boergesenia) extract, Caulerpa brachypus (genus Boerges dis Lanceae root extract, Genista tinctoria extract, common enia) extract, Caulerpa scalpelliformis (genus Boergesenia) duckweed extract, myrrha extract, Champia parvula extract, extract, Acetabularia ryukyuensis (genus Acetabularia) Sargassum siliquastrum extract, blueberry extract, mango extract, Closterium sp. extract, korekaete extract, Cos extract, dil extract, elemi extract, dammar extract, Vanilla marium sp. extract, Dictyosphaeria cavernosa (genus Dic bean extract, pine extract, Sabia japonica extract, Gastrodia tyosphaeria) extract, Oedogonium sp. extract, Pediastrum elata f viridis extract, red currant extract, Ulmus parvifolia sp. extract, Trentephohlia sp. (genus Trentephohlia) extract, (bark) extract, aguaii guasu extract, abiu extract, abiurana Zygnema sp. extract, and Vaucheria sp. extract, blue-green extract, yellow Zapote extract, ilang-ilang extract, Orchis algae extracts such as Aphanothece sacrum (genus Aphan graminifolia extract, uva tea extract, Epipactis papillosa othece) extract, microcystis extract, and Oscillatoria sp. extract, unboku extract, elderberry extract, Agave filifera cV. extract, brown algae extracts such as Pilavella sp. (genus Compacta extract, Agave victorae-reginae extract, Saguaro Pilavella) extract, Ectocarpus indicus (genus Ectocarpus) cactus extract, Calocarpum Sapota extract, Orchis fauriei extract, Sorocarpus micromorus (genus Sorocarpus) extract, extract, Lygodium Japonicum extract, karaya extract, garyu Ralfsia fingiformis (genus Ralfsia) extract, Sphacellaria extract, Trametes versicolor extract, candelilla extract, tribuloides (genus Sphacellaria) extract, Halopteris filicina Canna generalis extract, savory extract, Cereus peruvianus (genus Halopteris) extract, Cutleria cylindrica (genus Cut extract, cabeb extract, Ouillaia saponaria extract, Opuntia leria) extract, Cutleria multifida (genus Cutleria) extract, leucotricha extract, Opuntia tuna extract, guapeba velmelha Cutleria adspersa (genus Cutleria) extract, Dictyota dilatata extract, Cephalanthera erecta var. Shizuoi extract, goose (genus Dictyota) extract, Spatoglossum pacificum (genus berry extract, kutitiriba extract, Curculigo latiforia extract, Spatoglossum) extract, Stypopodiumr Zonale (genus Sty Ilex rotunda extract, Sorghum nervosum extract, Sapote popodium) extract, Elachista taeniaeformis (genus Ela amarillo extract, Salmonberry extract, Echinops gmelinii chista) extract, Halothrix ambigua (genus Halothrix) extract, Hylocereus cactus extract, Epimedium semperuirens extract, Leathesia diformis (genus Leathesia) extract, extract, Cymbidium goeringii extract, shoZuku extract, Agarum clathratum (genus Agarum) extract, Chordaria Sirobana-tuta extract, Cinchona succirubra extract, Suimu flagelliformis (genus Chordaria) extract, Eudesme virescens berry extract, starapple extract, Cymbidium ensifolium (genus Eudesme) extract, Tinocladia Crassa (genus Tin extract, Pinus Sylvestris extract, bilberry extract, caper ocladia) extract, Hydrilla verticillata (genus Hydrillata) extract, European mistletoe extract, Opuntia dillenii extract, extract, Acrothrix pacifica (genus Acrothrix) extract, Car senboku extract, Zougechu extract, Chinonanthus praecox f. pomitra costata (genus Carpomitra) extract, Sporochnus concolor extract, Dioscorea matsudai extract, darkSweet radiciformis (genus Sporochnus) extract, Nereia intricata cherry extract, Opuntia vulgaris extract, chokonosutei (genus Nereia) extract, Desmarestia tabacoides (genus Des extract, Artemisia argyi extract, Neottia kiusiana extract, marestia) extract, Akkesiphycus lubricum (genus Akkesiphy Galeola Septentrionalis extract, Commelina communis cus) extract, Punctaria latifolia (genus Punctaria) extract, extract, duberry extract, toukagikaZura extract, tragacanth Asperococcus bullosus (genus Asperococcus) extract, Coilo extract, triacanthos extract, Nigeria berry extract, rapeseed desme japonica (genus Coilodesme) extract, chishima-huku extract, Orchisjoo-iokiana extract, pau-doce extract, hakuk ronori (genus Shimahukuronori) extract, Hydroclathrus US 2006/0165636 A1 Jul. 27, 2006

clathratus (genus Hydroclathrus) extract, Chinoospora extract, Halarachnion latissimum (genus Halarachnion) implexia (genus Chinoospora) extract, Stictyosiphon extract, Sebdenia vandae (genus Sebdenia) extract, SOriferus (genus Stictyosiphon) extract, Striaria attenuata Catenela caespitosa (genus Catenela) extract, Phacelocar (genus Striaria) extract, Scytosiphon lonentaria (genus Scy pus japonicus (genus Phacelocarpus) extract, Caulacanthus to siphon) extract, Dictyosiphon foeniculaceus (genus Dic ustulatus (genus Caulacanthus) extract, Sarcodia ceylanica tvOsiphon) extract, Chorda filum (genus Chorda) extract, (genus Sarcodia) extract, Graciliaria incurvata (genus Ecklonia kurome (genus Ecklonia) extract, Thalasiophyl Graciliaria) extract, Gracilaria rhodocaudata (genus lum clathrus (genus Thalasiophyllum) extract, neirekonbu Graciliaria) extract, Graciliaria salicornia (genus (genus Neirekombu) extract, Macrocystis pyrifera (genus Graciliaria) extract, Gracilaria Srilankia (genus Graciliaria) Macrocystis) extract, buruukimo (genus Buruukimo) extract, extract, Graciliaria sublittoralis (genus Graciliaria) extract, and Scytosiphon lonentaria (genus Scytosiphon) extract, red Graciliaria ieillardii (genus Graciliaria) extract, Graciliaria algae extracts such as Porphyra pseudolinearis (genus Por edulis (genus Graciliaria) extract, Gracilaria eucheumoides phyra) extract, Porphyra dentata (genus Porphyra) extract, (genus Graciliaria) extract, Graciliaria lemaneiformis (genus tasa (genus Porphyra) extract, Porphyra variegata (genus Graciliaria) extract, Graciliaria punctata (genus Graciliaria) Porphyra) extract, Porphyra amplissima (genus Porphyra) extract, Graciliaria arcuata (genus Graciliaria) extract, extract, Audouinella howei (genus Audouinella) extract, Graciliaria blodgettii (genus Graciliaria) extract, Graciliaria Liagora Caenomyce (genus Liagora) extract, Ligora coronopifolia (genus Graciliaria) extract, Graciliaria cunei japonica (genus Liagora) extract, aokonahada (genus folia (genus Graciliaria) extract, Graciliaria salicornia Liagora) extract, Nemalion multifidum (genus Nemalion) (genus Graciliaria) extract, Tilotus lichenoides (genus Tvlo extract, Dermonema pulvinatum (genus Nemalion) extract, tus) extract, Ahnfeltia plicata (genus Ahnfeltiopsis) extract, Dermonama frappieri (genus Dermonama) extract, Scinaia Ahnfeltiopsis consinna (genus Ahnfeltiopsis) extract, Steno Okamurae (genus Scinaia) extract, Actinotorichia fragilis gramma interrupta (genus Stenogramma) extract, Chondrus (genus Actinotorichia) extract, Ptilonia Okadai (genus Pti vendoi (genus Chondrus) extract, Gloiocladia japonica lonia) extract, Gielidium subfastigiatum (genus Gellidium) (genus Gloiocladia) extract, Fauchea spinulosa (genus extract, Gelidium tenue (genus Gellidium) extract, yohira Fauchea) extract, Fauchea stipitata (genus Fauchea) (genus Gelidium) extract, Gelidium linoides (genus extract, Chrysymenia dwrightii (genus Chrysymenia) Gelidium) extract, Dudresnaya japonica (genus Dudre extract, Chrysymenia Okamurae (genus Chrysyvmenia) snaya) extract, Dudresnaya minima (genus Dudresnaya) extract, Coelarthrum opuntia (genus Coelarthrum) extract, extract, Hvalosiphonia caespitosa (genus Hyalosiphonia) Chamaebotry's Oergesenii (genus Coelarthrum) extract, Bot extract, Pikea yoshizaki (genus Pikea) extract, Dumontia ryocladia leptopoda (genus Botryocladia) extract, Crypta contorta (genus Dumontia) extract, Dumontia simplex rachne polyglandulosa (genus Cryptarachne) extract, (genus Dumontia) extract, Masudaphycus irregulare (genus Rhodymenia intricata (genus Rhodymenia) extract, Rhody Masudaphycus) extract, Constantinea subulifera (genus menia pertusa (genus Rhodymenia) extract, Webberella Constantinea) extract, Rhodopeltis borealis (genus Sty micans (genus Webberella) extract, Halosaccion saccatum laster) extract, Contarinia Okamurae (genus Contarinia) (genus Halosaccion) extract, Champia bifida (genus Cham extract, Peyssonnelia caulifera (genus Peyssonnelia) pia) extract, Champia expansa (genus Champia) extract, extract, Cruoriella japonica (genus Cruoriella) extract, Campylaephora hypnaeoides (genus Campylaephora) Amphiroa dilatata (genus Amphiroa) extract, Corallina offi extract, Campylaephora Crassa (genus Campylaephora) cinalis (genus Corallina) extract, Prionitis ramosissima extract, Herpochondria elegans (genus Herpochondria) (genus Grateloupia) extract, Grateloupia livida (genus extract, Reinboldiella Schmitziana (genus Reinboldiella) Grateloupia) extract, Grateloupia Okamurae (genus Grate extract, Marionella Schmitziana extract, Congregatocarpus loupia) extract, Grateloupia carnosa (genus Grateloupia) pacificus extract, Neoholmesia japonica extract, Sorella extract, Grateloupia turuturu (genus Grateloupia) extract, repens (genus Sorella) extract, Nienburgia japonica (genus Grateloupia lanceolata (genus Grateloupia) extract, Grate Nienburgia) extract, Neohypophyllum middendorfii (genus loupia kurogi (genus Grateloupia) extract, Prionitis patens Neohypophyllum) extract, Myriogramme polyneura (genus (genus Prionitis) extract, Polvopes polvideoides (genus Myriogramme) extract, Hideophyllum yezoense (genus Polyopes) extract, Carpopeltis maillardii (genus Carpopel Myriogramme) extract, Acrosorium venulosum (genus tis) extract, Prionitis angusta (genus Prionitis) extract, Car Acrosorium) extract, Acrosorium flabellatum (genus Acroso popeltis prolifera (genus Prionitis) extract, Prionitis Cris rium) extract, Acrosorium polyneurum (genus Acrosorium) pata (genus Prionitis) extract, Prionitis divaricata (genus extract, Acrosorium vendoi (genus Acrosorium) extract, Prionitis) extract, Prionitis articulata (genus Prionitis) Hymenena tenuis (genus Hymenena) extract, Martensia extract, Prionitis cornea (genus Prionitis) extract, Prionitis fragilis (genus Martensia) extract, Caloglossa continua elata (genus Prionitis) extract, Prionitis ramosissima (genus (genux Caloglossa) extract, Dasya sessilis (genus Dasya) Prionitis) extract, Cryptonemia Schmitziana (genus Cryp extract, Heterosiphonia japonica (genus Heterosiphonia) tonemia) extract, Schimmelmannia plumosa (genus Schim extract, Heterosiphonia pulchra (genus Heterosiphonia) melmannia) extract, Tichocarpus Crinitus (genus Tichocar extract, Rhodoptilum plumosum (genus Rhodoptilum) pus) extract, Callophyllis Okamurae (genus Callophyllis) extract, Digenea simplex (genus Digenea) extract, Pterosi extract, Kalymcnia sessilis (genus Kalymcnia) extract, Kal phonia pinnulata (genus Pterosiphonia) extract, Kintarosi lymenia sagamiana (genus Kalymcnia) extract, Kally menia phonia fibrillosa (genus Pterosiphonia) extract, Symphyo callophylloides (genus Kalymcnia) extract, Schmitzia cladia marchantioides (genus Symphyocladia) extract, japonica (genus Schmitzia) extract, Nemastoma nakamurae Syrmphyocladia latiuscula (genus Symphyocladia) extract, (genus Nemastoma) extract, Nemastoma lancifolia (genus Symphyocladia linearis (genus Symphyocladia) extract, Nemastoma) extract, Platona izunosimensis (genus Herposiphonia Suodisticha (genus Herposiphonia) extract, Platoma) extract, Schizymenia dubvi (genus Schizymenia) Herposiphonia subdisticha (genus Herposiphonia) extract, US 2006/0165636 A1 Jul. 27, 2006 22

Amansia glomerata (genus Melanamansia) extract, Melana dimethyl ether, ethyl methyl ether, dioxane, acetonitrile, mansia japonica (genus Melanamansia) extract, Melanama Xylene, benzene, chloroform, carbon tetrachloride, phenol, insia mitsui (genus Melanamansia) extract, Enantiocladia and toluene; acids adjusted to appropriate normality (e.g., Okamurai (genus Enantiocladia) extract, Lenormandiopsis hydrochloric acid, Sulfuric acid, nitric acid, phosphoric acid, lorenzii (genus Lenormandiopsis) extract, Neurymenia flax formic acid, and acetic acid); and alkalis (e.g., sodium inifolia (genus Neurymenia) extract, Cyanidium caldarium hydroxide, potassium hydroxide, calcium hydroxide, and (genus Cyanidium) extract, Nemralionopsis tortuosa (genus ammonia). However, when the presence of an organic Nemalionopsis) extract, and Thorea Okadai (genus Thorea) solvent is not preferable in accordance with the intended use, extract, carophyote extracts Such as Stonewort extract, Lam it is possible to use a method in which water may be used prothamnium succinctum extract, Nitellopsis obtusa (genus alone or extraction may be performed using a high volatile Nitellopsis) extract, Lychnothamnus extract, Nitella flexilis solvent which can be easily removed after the extraction, var. flexilis (genus Nitella) extract, Nitella acuminata var. followed by dissolving into purified water or the like after capitulifera extract, and Tolypella extract, yellow algae solvent removal. extract such as Chromulina sp. (genus Chromulina) extract, 0069. With regard to the extraction method, in consider plant extracts such as a mixed plant extract (arnica, hyperi ation of a raw material, the type of a solvent, and so on to cum, camomile, Tilia japonica, Equisetum arvense, yarrow, be used, extraction temperature, an extraction time period, sage, mallow, and Calendula officinalis, arinica, nettle, and a usage ratio of the solvent to the raw material can be cucumber, ground ivy, mallow, and eldertree) and mixed arbitrarily defined, respectively. The extraction temperature, fruit extract (lemon, apple, peach, and orange). which can be arbitrarily defined within the range of -4° C. 0.066 An animal, plant, or microbe raw material or to 100° C. in consideration of the nature of the solvent and another naturally-occurring raw material is arbitrarily so on, is preferably in the range of approximately 10° C. to selected and processed by the conventional process on the 40° C. in terms of the stability of components contained in basis of the type of a product to which it is added and the the raw material. In addition, the usage ratio of the solvent form thereof. Such as a process of any combination of those to the raw material can be arbitrarily defined within the selected from grinding, milling, washing, extraction, decom range of 4:1 to 1:100 (raw material:solvent in weight ratio), position, fermentation or, metabolic conversion by micro and is particularly preferably in the range of 1:1 to 1:10 (raw organism, fractionation, purification, compression, filtration, material:Solvent in weight ratio). desiccation, pulverization, granulation, dissolution, steril 0070) Examples of the decomposition mainly include ization, pH adjustment, deodorization, and depigmentation acidic decomposition, alkali decomposition, enzymatic to produce an animal, plant, or microbe extract to be used as decomposition, and high temperature and high pressure a bioactive component in the present invention. decomposition. In the acidic decomposition, it is preferable 0067. Of the animal, plant, and microbe extracts to be to use any of inorganic acids such as hydrochloric acid, used as the bioactive components in the present invention, Sulfuric acid, nitric acid, phosphoric acid, acetic acid, formic for the plant extract, various parts of a plant to be used for acid, oxalic acid, hydrogen bromide, perchloric acid, and the production can be arbitrarily chosen from, for example, periodic acid, or organic acids. In the alkali decomposition, a flower, Spica, pericarp, malleolus calyx, fruit, stem, lobe, it is preferable to use any of those including Sodium hydrox branch, foliage, trunk, bark, rhizome, root bark, root, seed, ide, potassium hydroxide, calcium hydroxide, ammonium or the entire plant. For the animal and microbe extracts, a hydroxide, barium hydroxide, Sodium carbonate, ammo substance to be used for the production can be arbitrarily nium carbonate, calcium carbonate, magnesium hydroxide, chosen from, for example, extracted products from various and Sodium silicate. In the acidic or alkali decomposition, cells, intracellular organelles, tissues, and organs. Alterna the concentration of an acid or alkali, reaction time, reaction tively, any part, cell, tissue, organ, or metabolite from a temperature, and so on can be arbitrarily defined for a raw transgenic or cell fusion product can be also used. Alterna material of interest. tively, the extracts can be obtained by Subjecting any part, cell, tissue, organ, and the like to cell culture. For example, 0071. In the enzymatic decomposition, in particular, it is cultured cells from the respective tissues (e.g., cultured cells preferable to use an enzyme having a function of decom of animal origins. Such as embryonic stem cells, fibroblasts, posing a protein, polysaccaride, lipid, or a combination Langerhans cells, macrophases, epidermic cells, and hepa thereof having a function important to a cell or tissue structure or the like. Examples of the enzyme include: tocytes), undifferentiated cells, cells in the middle of differ proteolytic enzymes (proteases) Such as amino peptidase, entiation, metabolites thereof, and so on may be also used. dipeptidase, dipeptidyl peptidase, tripeptidyl peptidase, car 0068 The solvents to be used for the extraction may be boxypeptidase, serine protease, trypsin, chymotrypsin, cys Suitably selected in consideration of the intended purpose teine protease, thiol protease, papain, aspartate endopepti and type of the product to be provided, or the process or the dase, metallo endopeptidase, promeline, thermolysin, like to be performed later and generally include one or a pronase, pepsin, rennin, pancreatin, chymopapain, ficin, mixture of two or more selected from: water, lower alcohols collagenase, and elastase; polysaccharide catabolic enzymes Such as methanol, ethanol, propyl alcohol, isopropyl alcohol, Such as amylase, Taka-amylase, cellulase, hemicellulase, butanol, and isobutanol, or hydrous lower alcohols; polyal pectinase, polygalacturonase, dextranase, and planase; and cohols such as propylene glycol, 1,3-butylene glycol, 1.2- cell-wall digesting enzymes Such as hen egg-white butylene glycol, 1,4-butylene glycol, 1,5-pentane diol. 1.2- lysozyme, human lysozyme, papaya lysozyme, turnip pentane diol. 1,3-pentane diol. 1.4-pentane diol. 1.3.5- lysozyme, barley lysozyme, Zymolyase, lysozyme chloride, pentane triol, glycerin, and polyethylene glycol (molecular glucanase, glucuronidase, chitinase, and chitosanase. In the weight of 100 to 100,000), or hydrous polyalcohol; various enzymatic decomposition, the concentration of an enzyme, organic solvents such as acetone, ethyl acetate, diethyl ether, reaction time, reaction temperature, pH of the solution, and US 2006/0165636 A1 Jul. 27, 2006 so on can be arbitrarily defined. In particular, it is preferable Kluyveromyces marxianus, or Kluyveromyces thermotoler to define them so that they correspond to optimal levels of ans), the genus Kockovaella, the genus Kurtzmanomyces, an enzyme to be used. the genus Leucosporidium, the genus Lipomyces, the genus 0072 Microbial fermentation or metabolic conversion Magnusiomyces, the genus Metschnikowia, the genus can be performed by inoculating at least one microorganism Microanthomyces, the genus Monilia, the genus Monospora, to a plant -or animal raw material or a processing product the genus Monosporella, the genus Mrakia, the genus Myce thereof provided as a Substrate to grow the microorganism. loblastanon, the genus Mycocandida, the genus Mycoderma, The inoculation of microorganism to the Substrate may be the genus Mycotorula, the genus Mycokluyveria, the genus carried out by: a method involving directly adding the Mycotoruloides, the genus Myxozyma, the genus Nadsonia, microorganism to the Substrate; adsorbing microorganism the genus Nectaromyces, the genus Nematospora, the genus on Such a carrier as alginate, polyvinyl, gelatin, etc., fol Octosporomyces, the genus Ogataea, the genus Oidium, the lowed by adding it in the form of fine beads constructed of genus Oospora, the genus Oosporidium, the genus Pachy for example, microorganisms and carrier, or using the solen, the genus Parasaccharomyces, the genus Paratoru microorganism immobilized on the tube wall of a bioreactor. lopsis, the genus Parendomyces, the genus Petasospora, the In the microbial fermentation or metabolic conversion, the genus Pichia (Such as Pichia amylophila, Pichiafarinose, microorganisms to be used can be defined as but not Pichia guilliermondii, Pichia membranifaciens, or Pichia particularly limited to, those other than pathogenic micro mogii) the genus Pityrosporum, the genus Procandida, the organisms, which typically represent remarkable toxicity to genus Procandida, the genus Prosporobolomyces, the genus the living body. Examples of a microorganism to be used and Proteomyces, the genus Pseudohansenula, the genus to be classified as yeast include the genus Aciculoconidium, Pseudomonilia, the genus Pseudomycoderma, the genus the genus Actonia, the genus Aessosporon, the genus Ambro Pseudosaccharomyces, the genus Pseudozyma, the genus Siozyma, the genus Amphierna, the genus Anthomyces, the Rhodomyces, the genus Rhodosporidium, the genus Rhodot genus Apiotrichum, the genus Arthroascus, the genus orula, the genus Saccharomyces (such as Saccharomyces Arxula, the genus AscotrichospOron, Ashbia, the genus aceti, Saccharomyces cerasi, Saccharomyces cerevisiae, Ashbya, the genus Asporomyces, Atelosaccharomyces, the Saccharomyces exiguus, Saccharomyces unisporus, or Sac genus Azymocandida, the genus Azymohansenula, the charomyces fibuligera), the genus Saccharomycodes, the genus. AZymomyces, the genus Azymoprocandida, the genus genus Saccharomycopsis, the genus Saturnispora, the genus Babjevia, the genus allistosporomyces, the genus Basidiot Schizoblastosporion, the genus Schizosaccharomyces, the richospOron, the genus Bensingtonia, the genus Blastobot genus Schwanniomyces, the genus Selenotila, the genus rys, the genus Blastodendrion, the genus Blastoderma, the Selenozyma, the genus Smithiozyma, the genus Sporidiobo genus Blastoschizomyces, the genus Botryoascus, the genus lus, the genus Sporobolomyces, the genus Sporothrix, the Botryozyma, the genus Brettanomyces (such as Brettanomy genus Stephanoascus, the genus Sterigmatomyces, the genus ces bruxellensis or Brettanomyces anomalus), the genus Sympodiomyces, the genus Syringospora, the genus Tetrapi Bullera, the genus Bulleromyces, the genus Candida (Such sispora, the genus Torula, the genus Torulaspora, the genus as Candida albicans, Candida amylolenta, Candida Torulopsis, the genus TrichospOron, the genus Udemiomyces, anomala, Candida boidinii, Candida entomaea, Candida the genus Vanrija, the genus Waltomyces, the genus Willia, etchellsii, Candida famata, Candida fermentati, Candida the genus Williopsis, the genus Wingea, the genus Xantho guilliermondii, Candida halophila, Candida intermedia, phyllomyces, the genus Yamadazyma, the genus Zendera, the Candida krusei, Candida lactosa, Candida lipolytica, Can genus ZygofabOspora, the genus Zygopichia, the genus dida mogii, Candida parapsilosis, Candida sake, Candida Zygohansenula, the genus Zygorenospora, the genus tropicalis, Candida versatilis, or Candida vulgaris), the Zygosaccharomyces, the genus Zymodebaryomyces, and the genus Castellania, the genus Chlamydozyma, the genus genus Zymonema. Examples of the microorganism to be Chromotorula, the genus Citeromyces, the genus Cladospo classified as a bacterium include the genus Acetobacter rium, the genus Clavispora, the genus Crebrothecium, the (such as Acetobacter aceti), the genus Achromobacter; the genus Cryptococcus, the genus Debaryomyces (such as genus Acidianus, the genus Acidobacterium, the genus Debaryomyces delbrueckii, Debaryomyces halotolerans, or Acidithiobacillus, the genus Acrocarpospora, the genus Debaryomyces hansenii), the genus Debaryozyma, the Actinoalloteichus, the genus Actinocoralia, the genus Acti genus Dekkera, the genus Dekkeromyces, the genus Dema nokineospora, the genus Actinomadura, the genus Actino tium, the genus Dipodascus, the genus Eeniella, the genus planes, the genus Actinopolyspora, the genus Actinosyn Enantiothamnus, the genus Endoblastoderma, the genus nema, the genus Aerococcus, the genus Aeronicrobium, the Endoblastomyces, the genus Endomyces, the genus Endo genus Agrobacterium, the genus Agromyces, the genus Ahr mycopsis, the genus Endyllium, the genus Entelexis, the ensia, the genus Alcaligenes, the genus Alicyclobacillus, the genus Eremascus, the genus Eremothecium, the genus genus Alloiococcus, the genus Alteromonas, the genus Eutorula, the genus Eutorulopsis, the genus Fabospora, the Amorphosporangium, the genus Ampullariella, the genus genus Fellomyces, the genus Fermentotrichon, the genus Amrycolata, the genus Amycolatopsis, the genus Aquaspir Filobasidium, the genus Galactomyces, the genus Geotri illum, the genus Arcanobacterium, the genus Arthrobacter, choides, the genus Geotrichum, the genus Guilliermondella, the genus Aureobacterium, the genus Azotobacter; the genus the genus Hanseniaspora, the genus Hansenula (such as Bacteroides, the genus Beneckea, the genus Bifidobacterium Hansenula anomala, Hansenula kluyveri, Hansenula miso, (such as Bifidobacterium bifidum, Bifidobacterium longum, Hansenula polymorpha, or Hansenula wickerhamii), the Bifidobacterium breve, or Bifidobacterium infantis), the genus Hypomyces, the genus Issatchenkia, the genus Klo genus Brachybacterium, the genus Brevibacillus, the genus eckera (Such as Kloeckera brevis, Kloeckera fluorescens, or Brevibacterium, the genus Brevundimonas, the genus Kloeckera japonica), the genus Kloeckeraspora, the genus Burkholderia, the genus Carnobacterium, the genus Catel Kluyveromyces (such as Kluyveromyces bulgaricus, latospora, the genus Cellulomonas, the genus Chainia, the US 2006/0165636 A1 Jul. 27, 2006 24 genus Chronobacterium, the genus Chryseobacterium, the monospora, the genus PrevOtella, the genus Propionibacte genus Citrobacter; the genus Clavibacter, the genus Coryne rium, the genus Proteus, the genus Protomonas, the genus bacterium, the genus Couchioplanes, the genus Cryptospo Pseudomonas, the genus Pseudonocardia, the genus Rah rangium, the genus Curtobacterium, the genus Dactylospo nella, the genus Rarobacter, the genus Rathavibacter; the rangium, the genus Deinococcus, the genus Delfia, the genus Rhizobium, the genus Rhizomonas, the genus Rhodo genus Demetria, the genus Dermacoccus, the genus Der bacter; the genus Rhodococcus, the genus Rhodopseudomo matophilus, the genus Elytrosporangium, the genus Entero nas, the genus Rhodospirillum, the genus Rothia, the genus bacter, the genus Erwinia, the genus Escherichia, the genus Rubrobacter, the genus Ruegeria, the genus Saccharomono Eubacterium, the genus Excellospora, the genus Exiguobac spora, the genus Saccharothrix, the genus Serratia, the terium, the genus Faenia, the genus Flammeovirga, the genus Sinorhizobium, the genus Sphingobacterium, the genus Flavobacterium, the genus Flexibacter; the genus genus Sphingomonas, the genus Sporolactobacillus, the Geodermatophilus, the genus Globicatella, the genus Glu genus Stenotrophomonas, the genus Streptoalloteichus, the conacetobacter, the genus Gluconoacetobacter, the genus genus Streptococcus (such as Streptococcus durans, Strep Glycomyces, the genus Gordona, the genus Gordonia, the tococcus faecalis, Streptococcus faecium, Streptococcus genus Halobacterium, the genus Halococcus, the genus bovis, Streptococcus equinus, Streptococcus mutans, Strep Herbidospora, the genus Hydrogenophilus, the genus tococcus salivarius, Streptococcus thermophilus, Strepto Hyphonicrobium, the genus Hyphomonas, the genus coccus agalactiae, Streptococcus mitis, Streptococcus pyo Intrasporangium, the genus Janibacter; the genus Jonesia, genes, Streptococcus pneumoniae, Streptococcus lactis, the genus Kibdelosporangium, the genus Kineococcus, the Streptococcus dysgalactiae, Streptococcus sanguis, Strepto genus Kineosporia, the genus Kitasatoa, the genus Kita coccus acidominimus, Streptococcus avium, Streptococcus Satospora, the genus Kitasatosporia, the genus Klebsiella, uberis, Streptococcus Cremoris, or Streptococcus diacetilac the genus Kocuria, the genus Kurthia, the genus Lactoba tis), the genus Streptomyces, the genus Streptosporangium, cillus (such as Lactobacillus rinae, Lactobacillus divergens, the genus Streptoverticillium, the genus Terrabacter, the Lactobacillus carnis, Lactobacillus piscicola, Lactobacillus genus Thermoactinomyces, the genus Thermobifida, the acidophilus, Lactobacillus amylophilus, Lactobacillus ani genus Thermobispora, the genus Thermocrispum, the genus malis, Lactobacillus brevis, Lactobacillus casei, Lactoba Thermomonospora, the genus Thermoplasma, the genus cillus curvatus, Lactobacillus bulgaricus, Lactobacillus del Thiobacillus, the genus Thiomonas, the genus Thiosphaera, brueckii, Lactobacillus fermentum, Lactobacillus the genus Weissella, the genus Xanthobacter, the genus fructivorans, Lactobacillus fructosus, Lactobacillus helveti Xanthomonas, and the genus Zymomonas. Examples of the cus, Lactobacillus hilgardii, Lactobacillus homohiochii, microorganism to be classified as ascomycetes, basidi Lactobacillus kefiri, Lactobacillus malefermentans, Lacto omycetes, or deuteromycetes except yeast include the genus bacillus murinus, Lactobacillus paracasei, and Lactobacil Allomyces, the genus Amoebidium, the genus AmorphOth lus paracasei Subsp. tolerans, Lactobacillus parakefiri, Lac eca, the genus Arthroderma, the genus Ascoidea, the genus tobacillus pentosus, Lactobacillus plantarum, Lactobacillus Ascobolus, the genus Ascodesmis, the genus Aspergillus, the reuteri, Lactobacillus rhamnosus, Lactobacillus sakei, Lac genus Aureobasidium, the genus Botryosphaeria, the genus tobacillus confusus, Lactobacillus virideiscens, Lactobacil Botryotinia, the genus Brachybasidium, the genus Byssoch lus johnsonii, Lactobacillus viscosus, Lactobacillus bunch lamrys, the genus Capnodium, the genus Ceratocystis, the neri, Lactobacillus fermentatae, Lactobacillus acidophil genus Ceratomryces, the genus Chaetonium, the genus aerogenes, Lactobacillus leichmannii, Lactobacillus Chrysella, the genus Chrysocelia, the genus Chytridium, the gasseri, Lactobacillus bifidus, Lactobacillus jugurt, Lacto genus Claviceps, the genus Cochliobolus, the genus bacillus caucasicus, Lactobacillus arabinosus, Lactobacil Coemansia, the genus Coleosporium, the genus Coniocha lus kunkeei, Lactobacillus nagelii, Lactobacillus formicalis, etidium, the genus Cordyceps, the genus Cronartium, the Lactobacillus pentoaceticus, Lactobacillus xylosus, or Lac genus Cyttaria, the genus Dasyspora, the genus Derchslera, tobacillus minutus), the genus Leuconostoc (such as Leu the genus Dichomyces, the genus Dothidea, the genus conostoc lactis, Leuconostoc dextranicum, Leuconostoc Endogone, the genus Entomophthora, the genus Emericella, mesenteroides, Leuconostoc oenos, Leuconostoc parame the genus Eupenicillium, the genus Eurotium, the genus senteroides, Leuconostoc Cremoris, or Leuconostoc citro Exobasidium, the genus Gibberella, the genus Glomus, the vorum), the genus Listonella, the genus Lucibacterium, the genus Graphiola, the genus Gymnoascus, the genus Har genus Luteococcus, the genus Magnetospirillum, the genus pella, the genus Helicomyces, the genus Helvella, the genus Marinilabilia, the genus Marinospirillum, the genus Hemicarpenteles, the genus Hyphochytrium, the genus Hip Mesorhizobium, the genus Metallosphaera, the genus dcrea, the genus Laboulbenia, the genus Labyrinthula, the Methylobacterium, the genus Microbispora, the genus genus Leptosphaeria, the genus Leptosphaerulina, the genus Micrococcus, the genus Microellobosporia, the genus Lophodermium, the genus Melanotaenium, the genus Micromonospora, the genus Mycobacterium, the genus Microascus, the genus Microstroma, the genus Medeolaria, Mycoplasma, the genus Nocardia, the genus Nocardioides, the genus Melampsora, the genus Melamsporella, the genus the genus Nonomuraea, the genus Nonomuria, the genus Morchella, the genus Monascus, the genus Monilinia, the Oceanospirillum, the genus Ochrobactrum, the genus Oer genus Monoblephalis, the genus Mycospharella, the genus Skovia, the genus Oligella, the genus Paenibacillus, the Nannizzia, the genus Nectria, the genus Neolecta, the genus genus Pediococcus (such as Pediococcus halophilis, Pedio Neurospora, the genus Nodulosphaeria, the genus coccus acidilactis, Pediococcus cerevisiae, Pediococcus Olpidium, the genus Peziza, the genus Penicillium, the pentosaceus, or Pediococcus urinae-equi), the genus Pedo genus Perenospora, the genus Pestalotiopsis, the genus bacter, the genus Peptococcus, the genus Peptostreptococ Phomopsis, the genus Phragmidiella, the genus Pneumocys cus, the genus Pilimelia, the genus Pimeliobacter; the genus tis, the genus Preussia, the genus Pleospora, the genus Planobispora, the genus Planococcus, the genus Plano Puccinia, the genus Pythium, the genus Ravenelia, the genus US 2006/0165636 A1 Jul. 27, 2006

Rickia, the genus Rhinocladiella, the genus Rhizidiomyces, calcium carbonate, magnesium carbonate, yellow iron the genus Rhizoctonia, the genus Sclerocleista, the genus oxide, red iron oxide, black iron oxide, ultramarine, chrome Saprolegnia, the genus Satioella, the genus Sclerotinia, the oxide, chrome hydroxide, carbon black, and calamine; inor genus Sclerotum, the genus Septobasidium, the genus Sor ganic reducers such as a hydrogen peroxide solution, Sodium daria, the genus Sporidiobolus, the genus Stibella, the genus persulfate, ammonium persulfate, sodium perborate, urea Stigmatomyces, the genus Sydowiella, the genus Talaromay peroxide, sodium percarbonate, sodium peroxytripolyphos ces, the genus Taphrina, the genus Thraustochytrium, the phate, Sodium bromate, potassium bromate, sodium peroxy genus Tolyposporium, the genus Trichoglossum, the genus pyrophosphate, Sodium peroxy-o-phosphate, a Sodium sili Trichoma, the genus Ustilago, the genus Verticillium, and cate-hydrogen peroxide adduct, a Sodium Sulfate-hydrogen the genus Xylaria. peroxide adduct, a sodium chloride-hydrogen peroxide adduct, a B-tyrosinase enzyme solution, a mushroom extract, 0073. In the microbial fermentation or metabolic conver strontium Sulfate, sodium sulfide, barium sulfide, and cal Sion, in addition to various kinds of raw materials including cium sulfide; redox agents such as thioglycolic acids and plant raw materials, animal raw materials, and naturally salts thereof (calcium thioglycollate, Sodium thioglycolate, occurring raw materials, various additional compounds and lithium thioglycollate, magnesium thioglycollate, and stron the like may be added to the raw materials to regulate or tium thioglycolate); and dye agents such as 5-amino-o- activate the growth or metabolism of the microorganism and cresol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, further to induce a specific biosynthesis or decomposition 1-amino-4-methylaminoanthraquinone, 3,3'-iminodiphenol, pathway. Examples of those compounds to be added include: 2,4-diaminophenoxyethanol hydrochloride, 2,4-diami compounds containing, as carbon Sources, carbohydrates nophenol hydrochloride, toluene-2,5-diamine hydrochlo Such as glucose, fructose, galactose, Sucrose, maltose, man ride, nitro-B-phenylenediamine hydrochloride, p-phenylene nose, lactose, glycerol, and starch, hydrocarbons such as diamine hydrochloride, N-phenyl-f-phenylenediamine ethane, methane, propane, and butane, and aliphatic acids hydrochloride, m-phenylenediamine hydrochloride, o-ami Such as formic acid, acetic acid, propionic acid, lauric acid, nophenol, N-phenyl-3-phenylenediamine acetate, 1,4-di palmitic acid, oleic acid linolic acid, and linolenic acid; aminoanthraquinone, 2,6-diaminopyridine, 1.5-dihydrox compounds containing, as nitrogen sources, ammonium ynaphthalene, toluene-2,5-diamine, toluene-3,4-diamine, salts such as ammonium Sulfate, ammonium hydrochloride, nitro-B-phenylenediamine, p-aminophenol, p-nitro-o-phe and ammonium phosphate, urea, uric acid, or amino acids; nylenediamine, p-phenylenediamine, p-methylaminophe and compounds containing vitamins, potassium, calcium, nol, picramic acid, Sodium picramate, N,N'-bis(4-aminophe magnesium, Sodium, Sulfur, phosphorus, and chlorine, nyl)-2,5-diamino-1,4-quinonediimine, 5-(2- which are required in various microorganisms, and a com hydroxyethylamino)-2-methylphenol, N-phenyl-B- pound containing iron, copper, Zinc, cobalt, nickel, boron, phenylenediamine, m-aminophenol, m-phenylenediamine, manganese, molybdenum, tin, selenium, Silicon, arsenic, 5-amino-o-cresol Sulfate, 2-amino-5-nitrophenol Sulfate, Vanadium, chromium, and fluorine. Furthermore, various o-aminophenol Sulfate, o-chlor-B-phenylenediamine Sulfate, factors such as optimal temperature, content of oxygen 4,4'-diaminodiphenylamine Sulfate, 2,4-diaminophenol Sul Supplied, pH, and pressure which affect the growth or fate, toluene-2,5-diamine Sulfate, nitro-p-phenylenediamine activation of metabolism of various microorganisms can be Sulfate, p-aminophenol Sulfate, p-nitro-o-phenylenediamine arbitrarily defined in response to the inherent properties of Sulfate, p-nitro-m-phenylenediamine Sulfate, p-phenylene various microorganisms. For the temperature, for example, diamine Sulfate, p-methylaminophenol sulfate, m-ami it can be arbitrarily defined within the range of 10°C. to 50° nophenol Sulfate, m-phenylenediamine Sulfate, catechol, C., and the pH can be also arbitrarily defined within the diphenylamine, C.-naphthol, hydroquinone, phloroglucin, range of 1 to 14. 2-hydroxy-5-nitro-2',4'-diaminoazobenzene-5'-sodium sul 0074. In the fractionation or purification, any technology fonate, and hematein. well-known in the art can be appropriately used. In addition to the solvent extraction, for example, fractionation with 0076 Examples of adjuvant components further include: liquid chromatography (such as ion-exchange chromatogra natural animal fragrances such as musk, civet, castor, and phy, ion-exclusion chromatography, affinity chromatogra amber grease; plant fragrances such as anise essential oil, phy, gel-filtration chromatography, size-exclusion chroma angelica essential oil, ylang-ylang essential oil, orris essen tography, hydrophilic adsorption chromatography, tial oil, fennel essential oil, orange essential oil, cananga hydrophobic adsorption chromatography, or ligand essential oil, caraway essential oil, cardamom essential oil, exchange chromatography); dialysis through a semi-perme guaiac wood essential oil, cumin essential oil, Lindera able membrane, crystallization or recrystallization of com umbellata essential oil, cinnaman essential oil, cinnamon ponents, filtration with filter paper, membrane filter, ultra essential oil, geranium essential oil, copaiba balsam essen filter, activated charcoal, and filter agent, fractionation tial oil, coriander essential oil, perilla essential oil, cedar precipitation methods such as centrifugation and the appli wood essential oil, citronella essential oil, jasmine essential cation thereof, density gradient separation methods such as oil, ginger-grass essential oil, Japanese cedar essential oil, a red Zonal centrifugation method and a density gradient spearmint essential oil, peppermint essential oil, star anise sedimentation equilibrium method, and the like can be used, essential oil, tuberose essential oil, clove essential oil, neroli respectively. essential oil, gauktheria essential oil, tolu balsam essential oil, patchouli essential oil, rose essential oil, palmarosa 0075 Examples of preparation-regulating ingredients essential oil, hinoki essential oil., hiba essential oil, Santal Such as a colorant, Surfactant, fragrance, and vehicle include: essential oil, petitgrain essential oil, bay essential oil, inorganic pigments such as silicic anhydride, magnesium Vetivert essential oil, bergamot essential oil, peru balsam silicate, bentonite, mica-titanium, bismuth oxychloride, Zir essential oil, bois de rose Oil, ho-leaf essential oil, mandarin conium oxide, magnesium oxide, Zinc oxide, titanium oxide, essential oil, eucalyptus essential oil, lime essential oil, US 2006/0165636 A1 Jul. 27, 2006 26 lavender essential oil, linaloe essential oil, lemongrass Red No.231, Red No.232, Red No.401, Red No.502, Red essential oil, lemon essential oil, rosemary essential oil, and No.503, Red No.504, Red No.506, Yellow No.4, Yellow Japanese mint essential oil; fragrances Such as other syn No.5, Yellow No.202 (1), Yellow No.202 (1), Yellow No.202 thetic fragrances; natural alcohols such as ethanol, isopro (2), Yellow No.203, Yellow No.402, Yellow No.403 (1), panol, laurylalcohol, cetanol, Stearylalcohol, cetostearylal Yellow No.406, Yellow No.407, Orange No.205, Orange cohol, oleylalcohol, lanolinealcohol, cholesterol, No.207, Orange No.402, Green No.3, Green No.204, Green phytosterol, and phenoxyethanol; synthetic alcohols such as No.205, Green No.401, Green No.402, Brown No.201 aminomerthylpropanol, 2-hexyldecanol, isostearylalcohol, Purple No.401, Blue No.1, Blue No.2, Blue No.202, Blue and 2-octyldodecanol; alcohols such as behenyl alcohol and No.203, Blue No.205, Black No.401, a red cabbage pig cetyl alcohol; esters such as isopropylmyristate, isopropy ment, a red rice pigment a madder pigment, an annatto lpalmitate, palmitate/myristate, butylstearate, hexyllaurate, pigment, a sepia pigment, a turmeric pigment, a scholar glycerinlaurate, glyceryl behenate? eicosadioate, myri pigment, a krill pigment, a persimmon pigment, caramel, stylmyristate, oleyloleate, decyloleate, octyldodecyl gold, silver, a gardenia pigment, a corn pigment, an onion myristate, hexyldecyldimethyl octanoate, diisobutyladipate, pigment, a tamarind pigment, a spirulina pigment, buck 2-hexyldecyladipate, diheptylundecyladipate, N-alkylglycol wheat (whole plant) pigment, a cherry pigment, a laver monoisoStearate, ethyleneglycol distearate, glycerin pigment, a hibiscus pigment, grape juice colour, a marigold monostearate, glycerylmonoStearate (glycerin monostear pigment, a purple potato colour, purple yam colour, lac ate), hexaglyceryl tristearate, isocetylisostearate, trimethy colour, and rutin. rolpropane trisoStearate, ethyleneglycol diethylhexanoate, 0078 Examples of adjuvants still further include: surfac neopentylglycol diethylhexanoate, neopentylglycol diisooc tants such as anioic Surfactants (alkylcarboxylate, alkylsul tanoate, cetyl 2-ethylhexanoate, trimethyrolpropane trieth fonate, alkylsulfate, and alkylphosphate Such as Sodium ylhexanoate, pentaerythritol tetraethylhexanoate, cetyloc laurylsulfate, potassium laurylsarcosine, sodium C14-O-ole tanoate, octyldodecyl gum, cetylactate, myristylactate, finsulfonate, Sodium paraffinsulfonate, and Sodium lauroyl diethylphthalate, dibutylphthalate, acetylated lanoline, eth N-methyltaurine), cationic Surfactants (an alkylamine salt yleneglycol distearate, ethyleneglycol monostearate, propy and alkyl quaternary ammonium salt Such as cetyltrimethy leneglycol monostearate, and propyleneglycol dioleate; and lammonium bromide, benzalkonium chloride, benzetho metalsoaps such as aluminum Stearate, magnesium Stearate, nium chloride, methylrosanilinium chloride, Stearyltrim Zinc Stearate, calcium Stearate, Zinc palmitate, magnesium ethylammonium chloride, Stearyltrimethylammonium myristate, Zinc laurate, and Zinc undecylate. chloride, N-palm oil fatty acid acyl-L-triethanolamine 0.077 Examples of adjuvant components furthermore glutamate, lauroylmethyl-3-alaninetriethanolamine salt, include: pigments/colorants such as 5-amino-o-cresol, dimethylaminopropylamide Stearate, triethanolamine o-aminophenol, m-aminophenol, p-aminophenol. 2,6-diami cocoylglutamate salt, isopropanolamine laurate, ammonium nopyridine, 5-(2-hydroxyethylamino)-2-methylphenol, laurylsulfate, dipolyoxyethylene methylammonium alkyl N,N-bis(B-hydroxyl)-3-phenylenediamine/sulfate, N,N- chloride, cationizated polyaklylpolymers, cetyltrimethyl bis(2-hydroxyethyl)-3-phenylenediamine, p-nitro-o-phe chloride, and dimethyldistearyl chloride), ampholytic sur nylenediamine, p-phenylenediamine, m-phenylenediamine, factants (carboxylic acid type-ampholytic Surfactants N-phenyl-3-phenylenediamine, resorcin, hydroquinone, (amino-type and betaine-type such as dodecylamino propi 2-hydroxy-5-nitro-2',4'-diaminoazobenzene/sodium sulfate, onate), a Sulfate-type ampholytic Surfactant, a Sulfonate-type toluene-2,5-diamine, 2-(2-hydroxyethylamino)-5-amino ampholytic Surfactant, and a phosphate-type ampholytic toluene, N,N-bis(B-hydroxyl)-p-phenyldiamine, N,N-bis(2- Surfactant), non-ionic Surfactants (an ether-type non-ionic hydroxyethyl)-f-phenylenediamine/sulfate, 5-amino-o- Surfactant, an etherester-type non-ionic Surfactant, an ester cresol/sulfate, p-aminophenol/sulfate, o-chloro-B- type ionic Surfactant, a blockpolymer-type non-ionic Surfac phenylenediamine/sulfate, 2-(2-hydroxyethylamino)-5- tant, and non-ionic Surfactants having nitrogen such as aminotoluene? sulfate, 4,4'-diaminodiphenylamine/sulfate, polyoxyethylene lauryl ether (POE(12)laurylether and the p-methylaminophenol/sulfate, p-phenylenediamine/sulfate, like), POE(3)sodium laurylethersulfate, POE(2.5)sodium m-phenylenediamine/sulfate, toluene-2,5-diamine/sulfate, tridecylether sulfate, POE(15)dodecyl ether, polyoxyethyl 2,4-diaminophenoxyethanol/hydrochloride, toluene-2,5-di ene(POE)cetyl ether (EO3.0, 2, and 20, 10EO, 6, and 60, and amine/hydrochloride, m-phenylenediamine/hydrochloride, the like), polyoxyethylene nonylphenyl ether, polyoxyeth 2,4-diaminophenol/hydrochloride, 3.31-iminodiphenol, ylene octylphenyl ether, polyoxyethylene(20EO)stearyl p-phenylenediamine/hydrochloride, N-phenyl-3-phenylene ether, Sorbitan monostearate, Sorbitan sesquioleate, palm oil diamine/hydrochloride, N-phenyl-f-phenylenediaminefac fatty acid Sorbitan, glyceride monolaurate, 4-4'dichloro-2- etate, 1,5-dihydroxynaphthalane, toluene-3,4-diamine, hydroxyphenyl ether, pentaerythritol fatty acid ester, p-methylaminophenol, N,N'-bis(4-aminophenyl)-2,5-di 4-guanidinobutyllauroamide, and the like), and other Sur amino-1,4-quinonediimine, o-aminophenol/sulfate, 2,4-di factants (natural Surfactants, derivatives of protein hydroly aminophenol/sulfate, m-aminophenol/sulfate, 2-amino-4-ni sates, polymer Surfactants, Surfactants containing titanium/ trophenol, 2-amino-5-nitrophenol, 1-amino-4- silicon, and fluorocarbon-based Surfactants); and treatment methylaminoanthraquinone, nitro-B-phenylenediamine? agents for hair such as selenium disulfide, an isoquinolinium hydrochloride, 1,4-diaminoanthraquinone, nitro-B- alkylbromide solution, Zinc pyrithione, biphenamine, thian phenylenediamine, picramic acid, sodium picramate, tol, quinine hydrochloride, and strong ammonia water. 2-amino-5-nitrophenol/sulfate, resorcinol, nitro-3-phe 0079. Other adjuvants, which can be used in combina nylenediamine/sulfate, p-nitro-o-phenylenediamine/sulfate, tion, include: hormones; a sequestrant; a pH adjuster, chela p-nitro-m-phenylenediamine/sulfate, Red No.2, Red No.3, tors such as EDTA (EDTA-2Na and EDTA-3Na); antivirus Red No. 102, Red No.104 (1), Red No. 105 (1), Red No. 106, and antifungus agents such as paraben, methyl paraben, Red No.201, Red No.227, Red No.230 (1), Red No.230 (2), ethyl paraben, and propyl paraben; refrigerant; Stabilizer; US 2006/0165636 A1 Jul. 27, 2006 27 emulsifier; animal and plant proteins and digests thereof (urea, for instance); animal and plant polysaccharides and -continued digests thereof animal and plant glycoproteins and digests Biotin 0.00001 wiw % thereof antiflash and antiallergic agents; a therapeutic agent Yeast extract 0.2 wiv 96 for wounds; refoamer; thickening agents such as Xanthan Total amount 10 L (a 15 L-jar fermenter) gum, quinceseed gum, and toraja gum, enzyme; purified water. (electron water, small clustered water, and the like): Determination of Molecular Weight of Y-polyglutamic Acid deodorant and deodorant; and solvents such as trichlorof Obtained in Production Example 1 luoroethane. 0082 The average molecular weight of Y-polyglutamic 0080 Hereinafter, production examples, test examples, acid obtained in Production Example 1 was determined to be and prescription examples will be provided for further 520,000. As a procedure for the determination, HPLC analy detailed explanation of the present invention. However, the sis with a gel-filtration column was carried out and the present invention is not limited to these examples at all. molecular weight was then calculated from a calibration curve prepared from a retention time corresponding to the resulting peaks using a known molecular weight marker. The PRODUCTION EXAMPLE 1. known molecular weight marker used was pullulan having a 0081 Bacillus subtilis stored in the cold at 4° C. was known molecular weight. inoculated in a liquid pre-culture medium with 1-loop inocu Conditions for Molecular Weight Determination lation and then cultivated at 25°C. for 72 hours with shaking at 100 strokes/min. Bacterial cells were collected from the 0083) Column: TSK-GEL GMPWXL medium by centrifugation after cultivation and then washed 0084 Mobile phase: 50-mM phosphate buffer (pH 6.5) with sterilized purified water. The bacterial cells after wash 0085. Flow rate: 0.5 mL/min ing were all added to a liquid medium for the production of 0086) Column temperature: 40° C. Y-polyglutamic acid and then cultivated under the culture conditions of an oxygen-transfer coefficient of 0.009 min' 0087 Detector: ABS 214 nm at 28°C., pH 8.0, during the cultivation from 0 to 24 hours TEST EXAMPLE 1. and then cultivated under the culture conditions of an oxygen-transfer coefficient of 0.007 min' at 25°C., pH 6.0, Comparative Test for Improvement Effect on Hair during the cultivation from 24 to 168 hours, while they were Strength kept under aerobic conditions for 7 days in total. After Test Method and Evaluation Method cultivations, the culture medium was filtrated to remove the bacterial cells. To the resulting filtrate added was 99.9% 0088 A numerical value, which was obtained by dividing the maximum stress measured at the time of pulling hair ethanol at a volume corresponding to one half of the total provided as a test sample by the diameter of the hair, was amount of filtrate and the whole was then stirred, thereby defined as an index of hair strength. A bundle of black hair obtaining a precipitate. Subsequently, the precipitate thus (13 cm in length and 2 g in weight) from a healthy human obtained was further washed with 99.9% ethanol for individual was dipped in a decolorizer (3.0 w/v hydrogen removal of excess moisture. After washing, the precipitate peroxide, 3.0 w/v ammonia aqueous Solution) for 30 min, was dissolved in purified water, thereby obtaining a Y-poly and then washed sufficiently with purified water, followed glutamic acid solution. The concentration of the Y-poly by standing in a drying machine at 40° C. to dry the hair glutamic acid solution was adjusted with purified water, to bundle. The same operation was repeated three times in total produce a 0.002%(w/v) Y-polyglutamic acid solution. and the resulting hair bundle was then provided as decol orized hair. The decolorized hair thus obtained was dipped for 5 minutes in the Y-polyglutamic acid solution of Pro Composition of liquid pre-culture medium duction Example 1, which was adjusted at 40°C., and then washed with purified water sufficiently, followed by stand Glucose 1.0 wiv 96 ing in a drying machine at 40°C. to dry the hair bundle. As Sucrose 1.0 wiv 96 a control for comparison, purified water adjusted at 40°C. Sodium L-glutamate 5.0 Wiv 96 Sodium chloride 0.01 Wiv 96 was used instead of the Y-polyglutamic acid solution and Magnesium sulfate O.OOS wiv 96 then the same operation was carried out. Each of various hair 7-hydrate 0.5 wiv 96 bundles obtained by the above operation and hair bundles Monopotassium phosphate Biotin 0.0001 Wiv 96 without decolorization (non-decolorized hair bundles) was Yeast extract 0.5 wiv 96 subjected to a rheometer (manufactured by Fudou Kogyo K. Total amount 500 mL. K) to determine the maximum stress of each hair and the (a 100 mL/500 mL-shake flask x5) strength of hair (gfum) was then determined by dividing the Composition of liquid medium for the production of Y-polyglutamic acid maximum stress by the diameter of hair. The results are Glucose 1.5 wiv 96 shown in FIG. 1. Sucrose 1.5 wiv 96 Sodium L-glutamate 5.0 Wiv 96 RESULTS OF TEST EXAMPLE 1 Sodium chloride 0.02 Wiv 96 Magnesium sulfate 7-hydrate 0.01 Wiv 96 0089. As a result of the measurement of hair strength in Monopotassium phosphate 0.5 wiv 96 each of the hair bundle on which the Y-polyglutamic acid solution of Production Example 1 was applied, the hair US 2006/0165636 A1 Jul. 27, 2006 28 bundle as a control on which purified water was applied, and PRESCRIPTION EXAMPLE 1 the non-decolorized hair bundle, the hair on which the Y-polyglutamic acid solution of Production Example was Composition for Hair Treatment applied showed higher hair strength than that of the hair as 0093) a control on which purified water was applied, and also showed hair strength similar to that of the non-decolorized hair. The foregoing found that the Y-polyglutamic acid of Production Example 1 has a Superior hair strength improve- Mass % ment effect and advantageously acts against the hair strength Liquid paraffin 12.O deterioration of damaged hair. Vaseline 12.O White beeswax 2.0 TEST EXAMPLE 2 Carboxyvinyl polymer O.1 Xanthan gum O.1 Comparative Test for Improvement Effect on Glycerin S.O Y-Sodium polyglutamate (MW about 520,000) 1O.O Frictional Coefficient of Hair Polyoxyethylene hydrogenated castor oil 3.0 EDTA-2Na O.OS Test Method and Evaluation Method Antiseptic Adequate amount Perfume Adequate amount 0090. Various hair bundles (hair bundle on which the Purified water Balance Y-polyglutamic acid solution was applied, the hair bundle as a control on which purified water was applied, and non decolorized hair bundle) obtained in Test Example 1 were also used in the present test in a similar manner, respectively. PRESCRIPTION EXAMPLE 2 From the hair bundle on which the Y-polyglutamic acid Solution was applied, 20 hairs having almost the same hair Composition for Hair Treatment diameter were mounted on a slide glass at 1-mm intervals 0094) Such that their cuticles were aligned in a certain direction. While each of the hairs was kept in straight, both ends of the hair were fixed by an epoxy resin. Then, the average frictional coefficient (MIU) of the fixed hairs was deter- Mass %0. mined using a friction-sensing tester KES-SE (manufactured 1,3-Butylene glycol 2.0 by Kato-Tech, Co., Ltd.). Then, the hair bundle as a control GlycerinStearyl trimethylammonium chloride O.S1.O on which purified water was applied and the non-decol- Methylphenyl polysiloxane 1.O orized hair bundle were also subjected to the same operation Ethanol 40.O to determine the average frictional coefficient of the respec- Y-SodiumAntiseptic polyglutamate (MW about 330,000) Adequate1O.O amount tive hairs. The results are shown in FIG. 2. Perfume Adequate amount Purified water Balance RESULTS OF TEST EXAMPLE 2

0.091 As a result of determining the average frictional PRESCRIPTION EXAMPLE 3 coefficient of each of the hair bundle on which the Y-poly glutamic acid solution of Production Example 1 was Shampoo applied, the hair bundle as a control on which purified water p was applied, and the non-decolorized hair bundle, the hair 0095 on which the Y-polyglutamic acid solution of Production Example 1 was applied showed a lower average frictional coefficient than that of the hair as a control on which purified water was applied and showed the average frictional coef- Mass % ficient approximate to that of the non-decolorized hair. The Ammonium lauryl Sulfate 1O.O foregoing found that the Y-polyglutamic acid of Production RS oil fatty acid acyl-L-glutamic acid 4.0 Example 1 has an excellent improvement effect on the trlethanolamine2-Alkyl-N-carboxymethyl-N-hydroxyethyl 3.0 frictional force of hair and advantageously acts on an imidazolinium betaine increase in frictional force of damaged hair. Lauric acid isopropanol amide 2.0 Ethylene glycol distearate 1.O 0092 According to the foregoing evaluation results, their Undecylenic acid trehalose O.S corresponding prescription examples will be described Y-SodiumDipotassium polyglutamate glycyrrhizinate (MW about 120,000) O.21.5 below. However, in each of the prescription examples, each Lithospermum root extract O.3 product may be one manufactured by the conventional Antiseptic O.1 meunodthod and only thune amountt to bbe mixedixed W111will be-shbe-Snown. IIn PifiedPerfume water AdequateBalance amount addition, the present invention is not limited to these pre Scription examples. US 2006/0165636 A1 Jul. 27, 2006 29

PRESCRIPTION EXAMPLE 4 PRESCRIPTION EXAMPLE 6 Shampoo Shampoo 0096) 0098)

Mass % Mass % Lauroylsodium N-methyl taurate S.O 4.0 POE (12) laurylether 2.0 POE (3) Sodium lauryl ether sulfate PEG 400 SO.O Lauroyl methyl-3-alanine triethanolamine salt S.O Glycerin 1O.O Triethanolamine cocoylglutamate S.O Ethylene glycol distearate 1.5 Lauryl amido propyl betaine S.O Amino denaturated silicone O.1 dodecyl aminopropionate 1.O Dimethylamino propyl amide Stearate 2.0 POE hydrogenated castor oil (40) 2.0 Y-Sodium polyglutamate (MW about 520,000) 3.0 O.2 2.0 e-Caproic acid Y-Sodium polyglutamate (MW about 350,000) Peach leaf extract O.S Pyridoxine hydrochloride O.3 Menthol Adequate amount Camomile extract O.3 Camphor Adequate amount Decyl glycerylglucoside 1.O Antiseptic Adequate amount Glycerin laurate 3.0 Coloring matter Adequate amount 4.0 Perfume Adequate amount Polydimethyl siloxane Purified water 4.0 Cetyl isooctanate 3.0 Ethanol Balance Wax 1.O Soy-protein hydrolysate O.2 Ethanol 3.0 Dipropylene glycol O.S PRESCRIPTION EXAMPLE 7 Sodium chloride 1.O Sodium benzoate O.3 Rinse Paraben O.2 Dibutylhydroxytoluene O.OS 0099) Perfume Adequate amount Citric acid 1.5 Purified water Balance Mass % Alkyl dipolyoxyethylene methyl ammonium chloride 4.0 Cetanol 2.5 Cationized polyacrylic polymer O.3 PRESCRIPTION EXAMPLE 5 Glycerin 3.5 Polyoxyethylene cetyl ether O.S Dimethylpolysiloxane 2.O Shampoo Y-Sodium polyglutamate (MW about 190,000) 2.O Trehalose O.S 0097 Blackberry lily extract O.3 Sodium chloride 1.O Ethanol 3.0 Perfume Adequate amount Mass % Citric acid 1.3 Purified water Balance POE (2.5) Sodium tridecyl ether sulfate 1O.O Sodium C14-O-olefin sulfonate S.O Sodium paraffin sulfonate 1.O Amido propyl betaine laurate 2.0 PRESCRIPTION EXAMPLE 8 Dodecyl carboxyethyl hydroxyethyl betaine 1.O POE (15) dodecylether 3.0 Rinse POE hydrogenated castor oil (40) 3.0 Y-Sodium polyglutamate (MW about 600,000) 2.5 Catechin O.1 0100 Basil extract O.3 Dodecyl glycerin ether 2.0 Cetyl isooctanate 1.O Liquid paraffin 1.O Mass % Collagen-derived tripeptide O.S Ethanol 2.0 Betaine-type ampholytic Surfactant 4.0 Sodium chloride O.S Cetanol 2.5 Sodium citrate O.2 Sorbitol S.O Paraben O.2 Y-Sodium polyglutamate (MW about 480,000) 2.5 Dibutylhydroxytoluene Adequate amount Tocotrienol nicotinate O.3 Ethylene glycol distearate 2.0 Rosemary extract O.3 Citric acid O.8 Polyoxyethylene cetyl ether (EO 3.0) O.S Purified water Balance Carboxymethyl cellulose O.8 Ethanol S.O US 2006/0165636 A1 Jul. 27, 2006 30

-continued -continued

Mass % Mass % Perfume Adequate amount Liquid paraffin 1O.O Citric acid 1.O Stearic acid 3.0 Purified water Balance Y-Sodium polyglutamate (MW about 620,000) 1.5 Carboxymethyl chitin O.S Hydroxypropyl chitosan O.S Glycerin monostearate 3.0 PRESCRIPTION EXAMPLE 9 Lanoline alcohol S.O Sweriia extract 1.O Rinse 1,3-Butylene glycol S.O Triethanolamine 1.O 0101 Methyl paraben Adequate amount Purified water Balance

Mass % PRESCRIPTION EXAMPLE 12 Stearyl trimethyl ammonium chloride 3.0 Sphingomyelin O.2 Casein hydrolysate O.O2 Treatment Y-Sodium polyglutamate (MW about 360,000) 3.0 Sodium N-methyl taurate O.2 0.104) Anthocyanidin O.2 Soybean seed extract O.S 2-Octyl dodecanol 1O.O Cetostearyl alcohol 2.0 Mass % Propylene glycol 1O.O Citric acid O.2 Stearyl trimethyl ammonium chloride 1.5 Potassium chloride O.3 Phosphatidylcholine O.OS Perfume Adequate amount Casein hydrolysate O.O2 Purified water Balance Y-Sodium polyglutamate (MW about 510,000) 2.5 3-Methyl-1,3-butanediol O.1 Carpronium chloride O.2 Japanese angelica extract O.S PRESCRIPTION EXAMPLE 10 Liquid paraffin 2.0 Silicone oil 3.0 Treatment Dipropylene glycol S.O POE hydrogenated castor oil derivative (60 EO) S.O 0102) Perfume Adequate amount Ethanol 3O.O Purified water Balance

Mass % 1,3-Butanediol S.O PRESCRIPTION EXAMPLE 13 Nemacystus extract O.2 Methyl paraben O.2 Phenoxyethanol O.3 Hair Cream Cetyl trimethyl chloride 2.O Dimethyl distearyl chloride 3.0 01.05 Castor oil 1.O Neopentylglycol di-iso-ocatinate S.O Liquid paraffin 8.0 Cetanol 6.0 Dimethylpolysiloxane 1.O Mass % St. polyglutamate (MW about 360,000) 3.0 Organopolysiloxane 1S.O -tocopherol acetate O.2 Purified water Balance Stearic acid O.S Squalene S.O Liquid paraffin 1O.O POE (20) cetylether 1.5

PRESCRIPTION EXAMPLE 11 orbitanE. monostearate 2.51.5 Glyceryl monostearate O.S Treatment Triethanolamine O.2 Polyvinylpyrrollidone S.O 0103) Propylene glycol 1O.O Y-Sodium polyglutamate (MW about 370,000) S.O Sesame extract O.S Tocopherol acetate O.2 Mass % Antiseptic Adequate amount Perfume Adequate amount Avocado oil S.O Purified water Balance Squalene S.O US 2006/0165636 A1 Jul. 27, 2006 31

PRESCRIPTION EXAMPLE 1.4 PRESCRIPTION EXAMPLE 17

Hair Cream Hair Lotion 0106) 01.09)

Mass % Mass % Polyoxyethylene (50 EO) hydrogenated castor oil 2.0 Liquid paraffin 1O.O Ethanol SO.O Squalene 7.0 Y-Sodium polyglutamate (MW about 250,000) 2.0 Jojoba oil 3.0 Hydroxypropyl cellulose 1.O Solid paraffin 3.0 Lemon peel extract O.S Polyoxyethylene cetyl ether 2.0 Avocado oil 1.O Y-Sodium polyglutamate (MW about 270,000) S.O 1,2-Pentanediol 1.O Y-Aminobutyrate O.2 Pyridoxine hydrochloride O.S Sanguisorba officina is extract O.3 1,3-Butylene glycol S.O Sorbitan sesquioleate 1.O Perfume Adequate amount Potassium hydroxide O.1 Purified water Balance Glycerin 3.0 Ethylparaben O.1 Purified water Balance PRESCRIPTION EXAMPLE 1.8

PRESCRIPTION EXAMPLE 1.5 Hair Lotion 0110 Hair Oil 01.07 Mass %

Ethanol 40.O Polyoxyethylene hydrogenated castor oil (60 EO) O.S Mass % Triethyl citrate 3.0 Decamethyl cyclopenta siloxane 7O.O Methylphenyl polysiloxane 4.0 Y-Sodium polyglutamate (MW about 520,000) 2.0 Dipropylene glycol 2.0 Green tea extract O.2 Diglycerin 1.O Perilia extract O.3 Y-Sodium polyglutamate (MW about 400,000) 1.5 Trichlorotrifluoroethane 7.0 Y-Orizanol O.2 Isopropyl alcohol 3.0 Aspartic acid 0.4 Dimethylpolysiloxane 4.0 Asparagine O.3 Soybean lecithin 1.O Mixed fruit extract (lemon, apple, peach, 1.O Perfume Adequate amount and orange) Mixed plant extract (arnica, hyperictim, camomile, 1.O Ethanol Balance Tilia japonica, Equisetum arvense, yallow, Sage, mallow, and Calendia officinalis) Panax ginseng extract O.1 Purified water Balance PRESCRIPTION EXAMPLE 16

Hair Lotion PRESCRIPTION EXAMPLE 19 0108) Hair-Styling Spray 0111 Mass % Ethyl glucoside 2.0 Eugenylglucoside O.S Mass % Glycerin 1O.O Vinylpyrrollidone? N,N-dimethylaminoethyl 1.O Octylacrylamide? acryl hydroxypropyl 3.0 methacrylate copolymer diethylsulfate solution butylaminoethyl methacrylate copolymer Polyoxyethylene hydrogenated castor oil (60 EO) O.3 Acryl resin alkanolamine O.S Ethanol 2O.O Aminomethyl propanol O.6 Y-Sodium polyglutamate (MW about 440,000) 2.5 Camomile extract 1.O Allantoin O.3 Y-Sodium polyglutamate (MW about 180,000) 1.O Fragaria ananassa extract 0.4 Grapefruit extract O.S Grape leaf extract 0.4 Purified water 2.0 Perfume Adequate amount Perfume Adequate amount Antiseptic Adequate amount Ethanol Balance Purified water Balance Propellant (LPG) 6.O US 2006/0165636 A1 Jul. 27, 2006 32

PRESCRIPTION EXAMPLE 20 PRESCRIPTION EXAMPLE 23 Hair Foam Hair-Coloring Pre-Treatment Agent 0112 0115)

Mass % Mass % Alkyl denaturated organopolysiloxane 2.O Beeswax 3.0 Mixed plant extract (arnica, stinging nettle, 1.O Behenyl trimethyl ammonium chloride 8.0 cucumber, Hedera helix, mallow, eldertree) Egg-yolk lecithin 2.5 Scuteilaria extract O.1 Y-Sodium polyglutamate (MW about 380,000) S.O Polyoxyethylene hydrogenated castor oil (60 EO) O.S Urea 0.4 Polyoxyethylene cetyl ether (10 EO) O.3 Aloe extract O.S Y-Sodium polyglutamate (MW about 330,000) S.O Vaseline S.O Sodium pyrrollidone carboxylic acid O.S Stearyl alcohol S.O Ergocalciferol O.1 Squalene 1O.O Chondroitin sulfate sodium salt 1.O Liquid paraffin 3O.O Purified water Balance Polyoxyethylene (20) cetylether 1.5 Polyoxyethylene (6) cetylether 2.5 Glycerin monostearate O.S 4-4'dichloro-2-hydroxy diphenylether O.S EDTA-3Na O.1 PRESCRIPTION EXAMPLE 21 Perfume Adequate amount Purified water Balance Hair Gel 0113 PRESCRIPTION EXAMPLE 24 Hair-Coloring Pre-Treatment Agent Mass % 0116 Carboxyvinyl polymer O.S Glycerin 2.0 Y-Sodium polyglutamate (MW about 520,000) S.O Tocotrienol acetate O.2 Mass % Hydrangea macrophylia extract O.S 8SS /o Clove extract O.3 Myristate palmitic acid 6.O Hinokithiol 1.O Glycerin behenic acid eicosane dicarboxylate 0.4 Ethanol 2O.O 2-Cetyl ethylhexanoate 3.0 Polyoxyethylene (20 EO) stearyl ether O.2 2-Octyl dodecanol 3.0 Perfume Adequate amount Cetanol 2.0 Purified water Balance Y-Sodium polyglutamate (MW about 450,000) S.O Sphingomyelin O.2 Cladosiphon Okamurants extract O.8 Glycerin S.O PRESCRIPTION EXAMPLE 22 Hydroxyethyl cellulose O.S Citric acid 1.O Perfume Adequate amount Hair Water Coloring matter Adequate amount Antiseptic Adequate amount 0114 Purified water Balance

Mass % PRESCRIPTION EXAMPLE 25 Orange leaf extract O.S Polyoxyethylene denaturated silicone O.S Hair-Coloring Post-Treatment Agent 3-Methyl-1,3-butanediol 2.0 0117) Y-Sodium polyglutamate (MW about 210,000) 1.5 Tocotrienol nicotinate O.1 Nor-dihydro-guaiaretic acid O.1 Stearyl trimethyl ammonium chloride O.S Polyoxyethylene laurate 0.4 Mass % Lauryldimethylamine oxide O.2 Sodium pyrrollidone carboxylic acid 1.O Hexaglyceryl monoisostearate S.O Methyl paraben O.3 Carboxyvinyl polymer O.S Sodium citrate O.1 Quince seed gum O.3 Hydroxy methoxybenzophenone sodium Sulfonate O.1 Methylsiloxane/polyoxyethylene copolymer 2.0 Perfume Adequate amount Y-Sodium polyglutamate (MW about 520,000) 4.5 Ethanol 2O.O Glucosylascorbic acid O.3 Purified water Balance Tocopheryl retinoate O.1 Nasturtium Officinale extract O.6 US 2006/0165636 A1 Jul. 27, 2006 33

PRESCRIPTION EXAMPLE 28 -continued Permanent Pre-Treatment Agent Mass % Polyoxyethylene hydrogenated castor oil O.3 0120 Dihydroxybenzophenone O.1 Methyl paraben O.1 Triethanolamine O.S Perfume Adequate amount Mass % Ethanol S.O Purified water Balance Cnidium extract O.S Hexaglyceryl tristearate 3.0 Alkyl denaturated carboxyvinyl polymer 0.4 Karayagum O.1 Methylpolysiloxane S.O PRESCRIPTION EXAMPLE 26 Liquid paraffin S.O Paraffin wax 3.0 Hair-Coloring Post-Treatment Agent Polyoxyethylene hydrogenated castor oil 2.0 3-Methyl-1,3-butanediol 1O.O 0118 Y-Sodium polyglutamate (MW about 260,000) 3.0 ChamaZulene O.2 Diclofenac sodium O.2 Dihydroxy benzophenone O.1 Propylparaben O.1 Mass % Methyl paraben O.3 Phenoxyethanol O.S Dipentaerythrite fatty acid ester 1.O Coconut oil-fatty acid sorbitan 2.0 4-Guanidinobutyl lauroamide 1.O Glycerin monostearate 1.O Stearyl trimethyl ammonium chloride O.2 Polypropylene glycol monostearate 2.0 Y-Sodium polyglutamate (MW about 220,000) S.O Triethanolamine O.S Lutein O.1 Perfume Adequate amount Beech leaf extract O.2 Purified water Balance Scuteilaria extract O.2 Cetanol 1.6 Behenyl alcohol O.2 Oley alcohol O.2 PRESCRIPTION EXAMPLE 29 Oleic acid O.2 Sostearic acid O.2 Oleyl oleate O.2 Permanent Post-Treatment Agent Glyceryl monostearate O.1 Sorbitan monolaurate O.1 0121) Polyoxyethylene (40) hydrogenated castor oil 1.O Pyrrollidone carboxylate Adequate amount Glycolic acid Adequate amount Methyl p-hydroxybenzoate Adequate amount Mass % Propyl p-hydroxybenzoate Adequate amount Perfume Adequate amount Polyoxyethylene cetyl ether 4.0 Purified water Balance Lanolin 4.0 Y-Sodium polyglutamate (MW about 510,000) S.O Cetyl alcohol O.S Ethanol S.O PRESCRIPTION EXAMPLE 27 Liquid paraffin 40.O P-dimethylamino octyl benzoate 1.5 Saivia extract S.O Permanent Pre-Treatment Agent Methyl p-hydroxybenzoate O.1 Perfume O.1 0119) Purified water Balance

Mass % PRESCRIPTION EXAMPLE 30

Beeswax 3.0 Vaseliaseline S.O Permanent Post-Treatment Agent Stearyl alcohol S.O Y-Sodium polyglutamate (MW about 180,000) 3.0 0122) Retinoic acid O.1 Cystine O.2 Liquid paraffin 3O.O Squalene 1O.O Mass % POE (60) cetylether 2.5 Maltitol O.2 Beeswax 3.0 Dimethylpolysiloxane 13.0 Y-Sodium polyglutamate (MW about 420,000) S.O EDTA-2Na O.1 Vaseline S.O Perfume Adequate amount Stearyl alcohol S.O Antiseptic Adequate amount Liquid paraffin 2S.O Purified water Balance Squalene 1O.O POE (60) cetylether 2.5 Jul. 27, 2006 34

-continued -continued

Mass % Mass % Dimethylpolysiloxane 2.O Birch extract 1.O Rooibos extract 0.4 Calcium pantothenate O.S EDTA-2Na O.1 B-Glycyrrhetic acid O.S Paraben O.1 Hydroxyethyl chitosan O.S Perfume O.1 Collagen protein enzymolysis product O.2 Purified water Balance Antibacterial agent Adequate amount Perfume Adequate amount Purified water Balance PRESCRIPTION EXAMPLE 31 Hair-Restoration and Growth Agent INDUSTRIAL APPLICABILITY 0.125 The composition for hair treatment containing 0123) Y-polyglutamic acid or a salt thereof of the present invention has excellent improvement effects on the strength and fric tional force of hair, so that it can provide tension or Mass % elasticity, or the like to damage hair to alleviate split hair and broken hair as well as improvements in combing and touch. Ethanol 6O.O In addition, the hair cosmetic for damaged hair, which Y-Sodium polyglutamate (MW about 310,000) 2.0 DL-C-Tocopherol acetate O.S contains such a composition for hair treatment, is capable of Capsicum tincture O.S preventing or alleviating various problems associated with Aloe extract 3.0 the deterioration of the hair strength mentioned above and of Resorcin O.S Dipotassium glycyrrhizinate O.S preventing or alleviating various problems associated in an Carboxymethyl chitin O.S increase in hair frictional force. Furthermore, it also exerts Collagen protein enzymolysis product O.2 its effect of moisture retention inherent to Y-polyglutamic Arginine O.25 acid or a salt thereof, preventing or alleviating effect on the Glutamine 0.25 Antibacterial agent Adequate amount generation of dandruff on the basis of such an effect, Perfume Adequate amount preventing effect on the feeling of Stickiness or creak, and Purified water Balance various effectiveness including appropriate residual ten dency to hair in a simultaneous manner. 1. A composition for hair treatment for damaged hair, PRESCRIPTION EXAMPLE 32 characterized by comprising Y-polyglutamic acid or a salt thereof. Hair-Restoration and Growth Agent 2. A hair cosmetic for damaged hair, characterized by comprising the composition for hair treatment according to 0124 claim 1. 3. A use of Y-polyglutamic acid or a salt thereof in production of a composition for hair treatment for damaged hair. Mass % 4. A method of administering a hair cosmetic containing Y-Sodium polyglutamate (MW about 250,000) 2.0 Y-polyglutamic acid or a salt thereof to a patient for impart Ethanol 6O.O Minoxidi S.O ing a strength to damaged hair and lowering a frictional DL-C-Tocopherol acetate O.S force of the hair. Caniharistincture O.S