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Benefits of Resveratrol Supplementation nutrients Benefits of Resveratrol Supplementation Edited by María P. Portillo and Alfredo Fernández-Quintela Printed Edition of the Special Issue Published in Nutrients www.mdpi.com/journal/nutrients Benefits of Resveratrol Supplementation Benefits of Resveratrol Supplementation Special Issue Editors Mar´ıaP. Portillo Alfredo Fern´andez-Quintela MDPI • Basel • Beijing • Wuhan • Barcelona • Belgrade Special Issue Editors Mar´ıa P. Portillo University of the Basque Country (UPV/EHU) Spain Instituto de Salud Carlos III (CIBERobn) Spain Alfredo Fernandez-Quintela´ University of the Basque Country (UPV/EHU) Spain Instituto de Salud Carlos III (CIBERobn) Spain Editorial Office MDPI St. Alban-Anlage 66 4052 Basel, Switzerland This is a reprint of articles from the Special Issue published online in the open access journal Nutrients (ISSN 2072-6643) from 2018 to 2019 (available at: https://www.mdpi.com/journal/nutrients/ special issues/Benefits of Resveratrol Supplementation) For citation purposes, cite each article independently as indicated on the article page online and as indicated below: LastName, A.A.; LastName, B.B.; LastName, C.C. Article Title. Journal Name Year, Article Number, Page Range. ISBN 978-3-03921-275-0 (Pbk) ISBN 978-3-03921-276-7 (PDF) c 2019 by the authors. Articles in this book are Open Access and distributed under the Creative Commons Attribution (CC BY) license, which allows users to download, copy and build upon published articles, as long as the author and publisher are properly credited, which ensures maximum dissemination and a wider impact of our publications. The book as a whole is distributed by MDPI under the terms and conditions of the Creative Commons license CC BY-NC-ND. Contents About the Special Issue Editors ..................................... vii Preface to ”Benefits of Resveratrol Supplementation” ........................ ix Alessandra Roggerio, C´eliaM. Cassaro Strunz, Ana Paula Pacanaro, Dalila Pinheiro Leal, Julio Y. Takada, Solange D. Avakian and Antonio de Padua Mansur Gene Expression of Sirtuin-1 and Endogenous Secretory Receptor for Advanced Glycation End Products in Healthy and Slightly Overweight Subjects after Caloric Restriction and Resveratrol Administration Reprinted from: Nutrients 2018, 10, 937, doi:10.3390/nu10070937 ................... 1 Jorge Hernandez-Valencia, Enrique Garcia-Villa, Aquetzalli Arenas-Hernandez, Jaime Garcia-Mena, Jose Diaz-Chavez and Patricio Gariglio Induction of p53 Phosphorylation at Serine 20 by Resveratrol Is Required to Activate p53 Target Genes, Restoring Apoptosis in MCF-7 Cells Resistant to Cisplatin Reprinted from: Nutrients 2018, 10, 1148, doi:10.3390/nu10091148 .................. 10 Nai-Wen Kan, Mon-Chien Lee, Yu-Tang Tung, Chien-Chao Chiu, Chi-Chang Huang and Wen-Ching Huang The Synergistic Effects of Resveratrol combined with Resistant Training on Exercise Performance and Physiological Adaption Reprinted from: Nutrients 2018, 10, 1360, doi:10.3390/nu10101360 .................. 27 Lech Sedlak, Weronika Wojnar, Maria Zych, Dorota Wygledowska-Promie nska,´ Ewa Mrukwa-Kominek and Ilona Kaczmarczyk-Sedlak Effect of Resveratrol, a Dietary-Derived Polyphenol, on the Oxidative Stress and Polyol Pathway in the Lens of Rats with Streptozotocin-Induced Diabetes Reprinted from: Nutrients 2018, 10, 1423, doi:10.3390/nu10101423 .................. 42 Inaki˜ Milton-Laskibar, Leixuri Aguirre, Usune Etxeberria, Fermin I. Milagro, J. Alfredo Mart´ınez and Maria P. Portillo Do the Effects of Resveratrol on Thermogenic and Oxidative Capacities in IBAT and Skeletal Muscle Depend on Feeding Conditions? Reprinted from: Nutrients 2018, 10, 1446, doi:10.3390/nu10101446 .................. 57 Alice Chaplin, Christian Carp´en´eand Josep Mercader Resveratrol, Metabolic Syndrome, and Gut Microbiota Reprinted from: Nutrients 2018, 10, 1651, doi:10.3390/nu10111651 .................. 73 Arnaud Courtois, Claude Atgi´e, Axel Marchal, Ruth Hornedo-Ortega, Caroline Lap`eze, Chrystel Faure, Tristan Richard and St´ephanieKrisa Tissular Distribution and Metabolism of trans-ε-Viniferin after Intraperitoneal Injection in Rat Reprinted from: Nutrients 2018, 10, 1660, doi:10.3390/nu10111660 ..................102 In-Ae Jang, Eun Nim Kim, Ji Hee Lim, Min Young Kim, Tae Hyun Ban, Hye Eun Yoon, Cheol Whee Park, Yoon Sik Chang and Bum Soon Choi Effects of Resveratrol on the Renin-Angiotensin System in the Aging Kidney Reprinted from: Nutrients 2018, 10, 1741, doi:10.3390/nu10111741 ..................113 v Andrea Ardid-Ruiz, Maria Ibars, Pedro Mena, Daniele Del Rio, Bego na˜ Muguerza, Cinta Blad´e, Llu´ıs Arola, Gerard Aragon`es and Manuel Su´arez Potential Involvement of Peripheral Leptin/STAT3 Signaling in the Effects of Resveratrol and Its Metabolites on Reducing Body Fat Accumulation Reprinted from: Nutrients 2018, 10, 1757, doi:10.3390/nu10111757 ..................128 Avinash Kumar, Melinee D’silva, Kshiti Dholakia and Anait S. Levenson In Vitro Anticancer Properties of Table Grape Powder Extract (GPE) in Prostate Cancer Reprinted from: Nutrients 2018, 10, 1804, doi:10.3390/nu10111804 ..................144 Michał Wici ´nski,Maciej Socha, Maciej Walczak, Eryk W´odkiewicz,Bartosz Malinowski, Sebastian Rewerski, Karol G´orskiand Katarzyna Pawlak-Osi ´nska Beneficial Effects of Resveratrol Administration—Focus on Potential Biochemical Mechanisms in Cardiovascular Conditions Reprinted from: Nutrients 2018, 10, 1813, doi:10.3390/nu10111813 ..................156 Pauline Chalons, Souheila Amor, Flavie Courtaut, Emma Cantos-Villar, Tristan Richard, Cyril Auger, Philippe Chabert, Val´erieSchni-Kerth, Virginie Aires and Dominique Delmas Study of Potential Anti-Inflammatory Effects of Red Wine Extract and Resveratrol through a Modulation of Interleukin-1-Beta in Macrophages Reprinted from: Nutrients 2018, 10, 1856, doi:10.3390/nu10121856 ..................170 Sonia L. Ram´ırez-Garza,Emily P. Laveriano-Santos, Mar´ıaMarhuenda-Mu ˜noz,Carolina E. Storniolo, Anna Tresserra-Rimbau, Anna Vallverd´u-Queraltand Rosa M. Lamuela-Ravent´os Health Effects of Resveratrol: Results from Human Intervention Trials Reprinted from: Nutrients 2018, 10, 1892, doi:10.3390/nu10121892 ..................187 Roberto Spogli, Maria Bastianini, Francesco Ragonese, Rossana Giulietta Iannitti, Lorenzo Monarca, Federica Bastioli, Irina Nakashidze, Gabriele Brecchia, Laura Menchetti, Michela Codini, Cataldo Arcuri, Loretta Mancinelli and Bernard Fioretti Solid Dispersion of Resveratrol Supported on Magnesium DiHydroxide (Resv@MDH) Microparticles Improves Oral Bioavailability Reprinted from: Nutrients 2018, 10, 1925, doi:10.3390/nu10121925 ..................205 Natacha Fourny, Carole Lan, Eric S´er´ee,Monique Bernard and Martine Desrois Protective Effect of Resveratrol against Ischemia-Reperfusion Injury via Enhanced High Energy Compounds and eNOS-SIRT1 Expression in Type 2 Diabetic Female Rat Heart Reprinted from: Nutrients 2019, 11, 105, doi:10.3390/nu11010105 ...................215 Margherita Springer and Sofia Moco Resveratrol and Its Human Metabolites—Effects on Metabolic Health and Obesity Reprinted from: Nutrients 2019, 11, 143, doi:10.3390/nu11010143 ...................230 vi About the Special Issue Editors Mar´ıa P. Portillo completed her studies in Pharmacy at the University of Navarra (Spain). She then submitted her PhD thesis at the University of Navarra (Spain). After the PhD period, she continued at the Paul Sabatier University and Unit U377 INSERM in Toulouse (France). Following the postdoctoral period, Prof. Portillo was appointed Lecturer in the Department of Nutrition and Food Science at the University of the Basque Country (UPV/EHU) where, in 2010, she became a Professor. She leads the group ”Nutrition and Obesity”, one of the Basque Excellence Research Centers, and is also enrolled in CIBERobn, which is supported by Health Institute Carlos III. This group maintains scientific collaborations with several groups from the United States and Europe. She has participated as a collaborator in 17 competitive research projects and has led 30 projects supported by the Spanish Ministry, the Government of the Basque Country, and UPV/EHU. She has published 173 papers and several book chapters and supervised 12 PhD theses. Prof. Portillo’s field of research covers the biological effects of different types of diets and biomolecules present in food on the prevention and treatment obesity, as well as on several obesity co-morbidities, such as insulin resistance and hepatic steatosis. In addition to her research activity, Prof. Portillo coordinates the bachelor’s degree in ”Nutrition and Dietetics”, the master’s program in ”Nutrition and Health”, and the doctorate program ”Nutrigenomics and Personalized Nutrition” at UPV/EHU. She is President of the Spanish Nutrition Society, and a member of the Spanish Agency for Food Safety and the Editorial Board of both Nutrition and The British Journal of Nutrition. Alfredo Fernández-Quintela is a graduate in Biology from the University of the Basque Country (UPV/EHU). Following his PhD degree, he conducted postdoctoral studies at the Rowett Research Institute (Aberdeen, Scotland). Thereafter, he was employed as an Associate Professor at the University of the Basque Country (UPV/EHU) in Vitoria (Spain) in 1994, where he is currently Lecturer in Human Nutrition and Food Sciences, and a Senior Researcher in the Department of Pharmacy and Food Sciences. His research focuses on the effects of bioactive molecules present in food (bioactive fatty acids, polyphenols) on obesity prevention and treatment,
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