Automating Laboratory Processes by Connecting Biotech and Robotic Devices—An Overview of the Current Challenges, Existing Solutions and Ongoing Developments
Total Page:16
File Type:pdf, Size:1020Kb
Load more
Recommended publications
-
Microplate Selection and Recommended Practices in High-Throughput Screening and Quantitative Biology
NLM Citation: Auld DSPh.D., Coassin PAB.S., Coussens NPPh.D., et al. Microplate Selection and Recommended Practices in High-throughput Screening and Quantitative Biology. 2020 Jun 1. In: Sittampalam GS, Grossman A, Brimacombe K, et al., editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-. Bookshelf URL: https://www.ncbi.nlm.nih.gov/books/ Microplate Selection and Recommended Practices in High-throughput Screening and Quantitative Biology Douglas S. Auld, Ph.D.,1 Peter A. Coassin, B.S.,2 Nathan P. Coussens, Ph.D.,3 Paul Hensley,4 Carleen Klumpp-Thomas,5 Sam Michael,5 G. Sitta Sittampalam, Ph.D.,5 O. Joseph Trask, B.S.,6 Bridget K. Wagner, Ph.D.,7 Jeffrey R. Weidner, Ph.D.,8 Mary Jo Wildey, Ph.D.,9 and Jayme L. Dahlin, M.D., Ph.D. 7,10 Created: June 1, 2020. Abstract High-throughput screening (HTS) can efficiently assay multiple discrete biological reactions using multi-well microplates. The choice of microplate is a crucial yet often overlooked technical decision in HTS and quantitative biology. This chapter reviews key criteria for microplate selection, including: well number, well volume and shape, microplate color, surface treatments/coatings, and considerations for specialized applications such as high-content screening. This chapter then provides important technical advice for microplate handling including mixing, dispensing, incubation, and centrifugation. Special topics are discussed, including microplate surface properties, plate washing, well-to-well contamination, microplate positional effects, well-to-well and inter-lot variability, and troubleshooting. This information and best practices derived from academic, government, and industry screening centers, as well as microplate vendors, should accelerate assay development and enhance assay quality. -
Towards Robotic Laboratory Automation Plug & Play: The" LAPP
Towards Robotic Laboratory Automation Plug & Play: The \LAPP" Framework Ad´amWolf´ ,∗,y,z David Wolton,{ Josef Trapl,{ Julien Janda,{ Stefan Romeder-Finger,x Thomas Gatternig ,x Jean-Baptiste Farcet ,x P´eter Galambos ,k and K´arolySz´ell k,? yBaxter AG, a Takeda company zDoctoral School of Applied Informatics and Applied Mathematics, Obuda´ University {Takeda Pharmaceuticals International AG, a Takeda company xBaxalta Innovations GmbH, a Takeda company kAntal Bejczy Center for Intelligent Robotics, Obuda´ University ?Alba Regia Technical Faculty, Obuda´ University, H-8000 Sz´ekesfeh´erv´ar,Hungary E-mail: [email protected] arXiv:2106.10129v2 [cs.RO] 26 Aug 2021 1 Abstract Increasing the level of automation in pharmaceutical laboratories and production facilities plays a crucial role in delivering medicine to patients. However, the particular requirements of this field make it challenging to adapt cutting-edge technologies present in other industries. This article provides an overview of relevant approaches and how they can be utilized in the pharmaceutical industry, especially in development labo- ratories. Recent advancements include the application of flexible mobile manipulators capable of handling complex tasks. However, integrating devices from many different vendors into an end-to-end automation system is complicated due to the diversity of interfaces. Therefore, various approaches for standardization are considered in this article, and a concept is proposed for taking them a step further. This concept enables a mobile manipulator with a vision system to \learn" the pose of each device and - utilizing a barcode - fetch interface information from a universal cloud database. This information includes control and communication protocol definitions and a representa- tion of robot actions needed to operate the device. -
Automation and Robotics Are Increasingly Prominent Features in the Laboratory
Automation and robotics are increasingly prominent features in the laboratory. Freeing up scientists to be creative and transforming the working day for many individuals. a brief history 1875 1945 1961 1981 1993 2004 The earliest mention of Little progress was The world’s first Dr Masahide Sasaki Dr Rod Markin at the The NIH and 300 laboratory automation made until the dust industrial robotic arm opened the first fully University of Nebraska leaders in research in the chemical had settled after WW2 for factory automation automated laboratory Medical Center created and government literature is from 18751, when commercially was released by at the Kochi Medical one of the world’s first identified automation that’s 52 years before available automated Unimation, paving the school to make rapid automated clinical lab technology as crucial the first TV was equipment started to way for all automated and accurate blood management systems, in accelerating medical demonstrated!2 become much more robotics to follow. sampling a reality. tying together discovery and complex. Spotting a Others quickly followed computer processing improving health.5 demand, Washington and, within 10 years, with physical robotics. University was the first 72% of Japanese The original to teach students how national university LAB-InterLink system to operate automated hospitals had adopted consisted of multiple equipment. 3 lab automation.1 testing stages along 112 feet of conveyor belts and was capable of full sample prep, testing and archiving.4 state of the market now $ 3.92 -
Laboratory Automation Selection Guide
Laboratory Automation Selection Guide Issue 2 The Equipment Compatibility Program Quality and Compatibility, Only from Corning. Corning Life Sciences maintains a comprehensive equipment compatibility program in which leading equipment manufacturers certify the compatibility of our products with their instruments. This information is continually updated with our new products as well as new instruments. Corning microplates offer compatibility with a wide range of laboratory instrumentation, including microplate readers, microplate washers, liquid handling instruments, automation accessories, and robotic systems. To make it easy to identify the Corning microplates that perform well with your instruments, we’ve assembled an Equipment Reference Guide with the help of manufacturers from throughout the industry. The Guide is available at www.corning.com/lifesciences. To ensure the accuracy of this reference guide, we invited leading manufacturers to test our microplates on their instru- ments using extensive criteria for fit and function. For example, a microplate reader manufacturer would have tested a Corning microplate for proper fit in the microplate carrier, suitable optical performance, and compatibility with all of the instrument’s accessories, including microplate stackers and bar code readers. If the microplate met all criteria, the manufacturer then signed a form certifying that the microplate was tested for fit and function and found compatible with their instrument and all relevant accessories. So you have their assurance as well as ours that the Corning microplates you choose will perform as needed. Please use this Equipment Reference Guide with confidence. Expert assistance is just a telephone call or email away Customer service and technical representatives are available to answer any question – from pricing and product availability to protocols and applications advice. -
NOMENCLATURE in LABORATORY ROBOTICS and AUTOMATION (IUPAC Recommendations 1994)
Pure & Appl. Chern., Vol. 66, No. 3, pp. 609-630, 1994. Printed in Great Britain. @ 1994 IUPAC INTERNATIONAL UNION OF PURE AND APPLIED CHEMISTRY ANALYTICAL CHEMISTRY DIVISION COMMISSION ON ANALYTICAL NOMENCLATURE* COMMISSION ON GENERAL ASPECTS OF ANALYTICAL CHEMISTRY? NOMENCLATURE IN LABORATORY ROBOTICS AND AUTOMATION (IUPAC Recommendations 1994) Prepared for publication by H. M. (Skip) KINGSTON' and M. L. KINGSTON2 'Department of Chemistry, Duquesne University, Pittsburgh, PA 15282, USA 2Pittsburgh Regional Library Center, Pittsburgh, PA 15221, USA *Membership of the Commission during the period (1987-1989) when this report was being prepared is given hereunder (Note: The Commission ceased to exist after the 35th IUPAC General Assembly, Lund, 1989). Chairman: R. E. Van Grieken (Belgium); Secretary: C. L. Graham (UK); Titular Members: C. A. M. G. Cramers (Netherlands), L. A. Cume (USA), W. Honvitz (USA), D. Klockow (FRG), M. Parkany (Switzerland); Associate Members: L. S. Ettre (USA), D. M. Everaerts (Netherlands), Y.Gohshi (Japan), P. S. Goel (India), H. M. Kingston (USA), G. J. Patriarche (Belgium), D. L. Rabenstein (USA), J. W. Stahl (USA); National Representatives: Magda Ariel (Israel), K. Danzer (GDR), U. L. Haldna (USSR), D. R. Reeves (New Zealand), B. Schreiber (Switzerland), J. Stary (Czechoslovakia), C. Svehla (UK). +Membershipof the Commission during the preparation of this report (1989-93) was as follows: Chairman: 1989-91 F. Ingman (Sweden); 1991-93 W. E. van der Linden (Netherlands); Vice-chairman: 1989-91 R. E. van Grieken (Belgium); Secretary: 1989-91 W. E. van der Linden (Netherlands); Co-Secretary: 1989-91 C. L. Graham (UK); Secretary: 1991-93 C. L. Graham (UK); Titular Members: L. -
Laboratory Robotics: New Opportunities Internal
December 2018 Volume 13 • Number 11 LabManager.com FOSTERING PRODUCTIVITY AT THE BENCH OR IN THE FIELD Internal Communication Laboratory Robotics: New Opportunities Lab Automation Product Resource Guide Follow us on www.genohm.com squad when they do. they happen, and alert your current with industry trends. defenses prevent errors before and is exible so you can stay conguration, and automatic and maintain. It saves you money An arsenal of rules, ags, The right LIMS is easy to set up Reduce Errors Investment workow, everytime. efciently and protect data. tracking samples in every permissions to work more creating digital locations and access with user, role, and group Foil the gambits of chaos by You control the gateways of Protection Visibility Management Capabilities all in a Single Solution, look no further than SLIMS! laboratory needs Sample Management, an Electronic Laboratory Notebook or Workow SLIMS is a digital platform used for managing all information in a laboratory. Whether your They deserve SLIMS Super Power Your Lab is full of heroes Your Lab is full of heroes They deserve SLIMS Super Power SLIMS is a digital platform used for managing all information in a laboratory. Whether your laboratory needs Sample Management, an Electronic Laboratory Notebook or Workow Management Capabilities all in a Single Solution, look no further than SLIMS! Visibility Protection Foil the gambits of chaos by You control the gateways of creating digital locations and access with user, role, and group tracking samples in every permissions to work more workow, everytime. efciently and protect data. Reduce Errors Investment An arsenal of rules, ags, The right LIMS is easy to set up conguration, and automatic and maintain. -
Laboratory Automation and Robotics
Journal of Automatic Chemistry, Vol. 12, No. 6 (November-December 1990), pp. 227-250 The 1990 International Symposium on Laboratory Automation and Robotics The eighth meeting on this subject was held in Bostonfrom 16 September to 19 September 1990, and brought together around 300 delegates mainly from the USA but with a few from other countries. Hosted by Zymark, the conference covered various facets of automation whilst focusing on laboratory robotics. The symposium included a series ofplenary lectures, invited lectures andposter sessions. The highlights were, for this delegate, thejqrst plenary by Glenn Taylor of Shell (on 'Roboticsfuljqll a strategic need') and a visit to the Zymarkfacility where several distinct robotic systems were in evidence. Whilst promoted as robotic systems these exhibits included quite a considerable degree of laboratory automation, especially solution handling. Glen Taylor's plenary session set the meeting off on a high note. He outlined his company's commitment to automation and robotics and described the changes that encouraged this move, and the problems associated with the acceptance by staff etc., prior to introducing it into all applications. We are in a new culture where the focus is on the customer's needs for analysis rather than just for numbers. New demands by regulatory requirements, environmental requirements, pressures from competition and, in the oil business, by a change in crude starting materials, are specc factors which have changed customers' needs. Accurate, cost-effective analyses are now ofparamount importance and these require good quality control, automation and robotics. A vital role for automation is to improve the credibility of analytical results and Dr Taylor suggested that up to 30% of all analytical demands werefor blind duplicates- sent to test the analyst rather than because they were needed. -
Process Automation for Analytical Measurements Providing High Precise Sample Preparation
Process Automation for Analytical Measurements Providing High Precise Sample Preparation in Life Science Applications Dissertation zur Erlangung des akademischen Grades Doktor-Ingenieur (Dr.-Ing.) der Fakultät für Informatik und Elektrotechnik der Universität Rostock Ellen Vorberg eingereicht am 25.02.2015 in Rostock verteidigt am 08.09.2015 in Rostock Supervisors 1. Prof. Dr.-Ing. habil. Kerstin Thurow, University of Rostock, Center for Life Science Automation 2. Prof. Dr.-Ing. Norbert Stoll, University of Rostock, Institute of Automation 3. Prof. Robin A. Felder, Ph.D., University of Virginia, School of Medicine, Department of Pathology, Charlottesville, VA Acknowledgment First of all, I would like to thank Prof. Dr. Kerstin Thurow for her continuous support throughout my PhD studies and dissertation work. I am truly grateful for her advices and suggestions and, moreover, for the excellent laboratory equipment. Furthermore, I would like to extend my thanks to all the staff members of celisca and the Institute of Automation. Especially, I would like to thank Sybille Horn, Dr. Heidi Fleischer, Dr. Thomas Roddelkopf, Lars Woinar, Heiko Engelhardt, Dr. Hui Liu, Dr. Sebastian Neubert, and Dr. Steffen Junginger for technical support. Most importantly, I thank my beloved husband, Mike Vorberg, for his love, support, and encouragement. Table of Contents Table of Contents List of Figures ............................................................................................................................................ i Sources of Figures -
Working with Laboratory Automation in Synthetic Biology
This thesis has been submitted in fulfilment of the requirements for a postgraduate degree (e.g. PhD, MPhil, DClinPsychol) at the University of Edinburgh. Please note the following terms and conditions of use: This work is protected by copyright and other intellectual property rights, which are retained by the thesis author, unless otherwise stated. A copy can be downloaded for personal non-commercial research or study, without prior permission or charge. This thesis cannot be reproduced or quoted extensively from without first obtaining permission in writing from the author. The content must not be changed in any way or sold commercially in any format or medium without the formal permission of the author. When referring to this work, full bibliographic details including the author, title, awarding institution and date of the thesis must be given. Amphibious Researchers: working with laboratory automation in synthetic biology Chris Mellingwood PhD University of Edinburgh October 2018 ii I declare that this thesis has been composed solely by myself and that it has not been submitted, in whole or in part, in any previous application for a degree. Except where stated otherwise by reference or acknowledgment, the work presented is entirely my own. Signature: 5 June 2019 iii Acknowledgements I have been fortunate to have incredibly insightful and patient academic mentors willing to share their knowledge and experiences. I am very grateful to my supervisors Jane Calvert, Pablo Schyfter, and Alistair Elfick for their time, generosity, and thoughtful advice. Special thanks also go to Dominic Berry, Emma Frow, Julie and David Morroll for their invaluable support and guidance. -
Automation 1 Automation
Automation 1 Automation Automation is the use of control systems and information technologies reducing the need for human intervention.[1] In the scope of industrialization, automation is a step beyond mechanization. Whereas mechanization provided human operators with machinery to assist them with the muscular requirements of work, automation greatly reduces the need for human sensory and mental requirements as well. Automation plays an increasingly important role in the world economy and in daily experience. KUKA Industrial Robots being used at a bakery for food production A series of articles on Automation Robotics • Cybernetics Trade-shows ASP-DAC (Asia-Pacific) • DAC DATE (Europe) • ICCAD Awards IEEE Robotics and Automation Award Robots Industrial robot Autonomous research robot Domestic robot Home Automation Laboratory automation Integrated library system Database administration and automation Building automation Automation 2 Artificial intelligence Automated attendant Automated guided vehicle Automated highway system Automated pool cleaner Automated teller machine Automatic painting (robotic) Pop music automation Robotic lawn mower Telephone switchboard Social movements Technocracy movement Venus Project • Zeitgeist Movement Impact Automation has had a notable impact in a wide range of highly visible industries beyond manufacturing. Once-ubiquitous telephone operators have been replaced largely by automated telephone switchboards and answering machines. Medical processes such as primary screening in electrocardiography or radiography -
ELISA Automation Springfield, NJ 07081 AB104A NOV 2002 TEL 973-376-7400
Hudson Control Group 10 Stern Avenue ELISA Automation Springfield, NJ 07081 AB104A NOV 2002 TEL 973-376-7400 www.hudsoncontrol.com INTRODUCTION The ELISA, or Enzyme-Linked ImmunoSorbent Assay, is a commonly used tool for the detection of small quantities of a target compound in solutions such as serum, urine, cell supernatants, etc. Since this is an immunoassay, the success of an ELISA experiment is dependent on the quality of the antibody in relation to its ability to specifically bind with the target compound, or antigen. ELISA experiments can be performed in a variety of ways. While the details of ELISA are beyond the scope of this document, we can summarize the concepts of a generic ELISA as follows: · A microplate is coated with antibody (or antigen). · Samples, controls, and standards are added to the wells of the microplate, and incubated between ambient and 37° C for some time period. During the incubation, either some amount of the antigen in the sample will bind with the precoated antibody or the antibody in the sample will bind with the precoated antigen. Some may not bind; this is referred to as unbound antigen or antibody. · After the incubation, the unbound entities are washed away. This wash is typically a repeated cycle of adding wash buffer, soaking, and removing the liquid in each well. · A secondary antibody called the conjugate is added. (This typically has an enzyme attached that will react with a substrate to produce a color change.) Another incubation period is performed, during which the conjugate will bind to the antibody-antigen complex in the plate. -
Automation 1 Automation
Automation 1 Automation Part of a series on Automation • Robotics • Cybernetics Trade shows • ASP-DAC • DAC • DATE • ICCAD Awards IEEE Robotics and Automation Award Robots Industrial robot Autonomous research robot Domestic robot General purpose Home automation Laboratory automation Integrated library system Database administration and automation Broadcast automation Console automation Building automation Specific purpose Automated attendant Automated guided vehicle Automated highway system Automated pool cleaner Automated teller machine Automatic painting (robotic) Pop music automation Robotic lawn mower Telephone switchboard Social movements Automation 2 • Technocracy movement • Venus Project • Zeitgeist Movement Automation is the use of machines, control systems and information technologies to optimize productivity in the production of goods and delivery of services. The correct incentive for applying automation is to increase productivity, and/or quality beyond that possible with current human labor levels so as to realize economies of scale, and/or realize predictable quality levels. In the scope of industrialisation, automation is a step beyond mechanization. Whereas mechanization provides human operators with machinery to assist them with the muscular requirements of work, automation greatly decreases the need for human sensory and mental requirements while increasing load KUKA industrial robots being used at a bakery for food production capacity, speed, and repeatability. Automation plays an increasingly important role in the world economy and in daily experience. Automation has had a notable impact in a wide range of industries beyond manufacturing (where it began). Once-ubiquitous telephone operators have been replaced largely by automated telephone switchboards and answering machines. Medical processes such as primary screening in electrocardiography or radiography and laboratory analysis of human genes, sera, cells, and tissues are carried out at much greater speed and accuracy by automated systems.