THE RESEARCH TRIANGLE PARK 2017 COMPANY DIRECTORY

TABLE OF CONTENTS Connect With Us ABOUT RTP 2 www.rtp.org Phone: 919.549.8181 REGIONAL MAP 3 Fax: 919.549.8246 [email protected] SERVICE PROVIDERS 4 RTP Headquarters COMPANY LISTINGS 5 12 Davis Drive, P.O. Box 12255 INDEX: ALPHABETICAL 69 Research Triangle Park, NC 27709 @TheRTP INDEX: BY SIZE 72 The Research Triangle Park The RTPNC’s Channel ABOUT RTP Key RTP Facts www.rtp.org/about-us The Research Triangle Park’s creation in 1959 7,000 acres (2,833 hectares) remains one of the most transformational public-private 264+ research companies partnerships in the history of North Carolina – and one well before its time, due to the visionary ambitions of government, 48,495+ high-tech workers business and academic leaders to create a more competitive 22.5 million sq. ft. of built space economic base that would carry the state into the 21st century.

Today, RTP is recognized around the world for its critical mass of pioneering research, university-industry partnerships, multi- national businesses and a globally competitive talent pool. It is among the largest research parks in the U.S., currently home to more than 260 companies that have created a culture of scientific advancement and collaboration.

Industry Profile of RTP 45% Biotech & Life Sciences 17% Information Technology 11% Business & Prof. Services

3% Clean & Green Tech RTP 180 at The Frontier 2% Education 2% Financial Services & Tech 9% Foundations, Institutes & The 2017 Company Directory was produced by the Research Scientific Assoc. Triangle Foundation of North Carolina, the nonprofit owner and 7% Instruments & Materials developer of the Research Triangle Park. Information was provided by individual companies in RTP and is current as of March 2017, unless 5% Service Providers otherwise noted.

The Research Triangle Park (RTP) is a 7,000-acre area which is specially designated for scientific research and production activities. Connect With Us This directory lists only those companies located within the Park’s @TheRTP www.rtp.org boundary, as shown on the map on the following page. The Research Triangle Park [email protected] The RTPNC’s Channel 2 See more at www.rtp.org/map Hillsborough 501 Miles 0 2 4 8

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ORANGE Falls Lake COUNTY Duke Southeastern Baptist University Durham Theological Seminary 15 Tech NC Central DURHAM 50 501 Wake University COUNTY 147 Forest WAKE Chapel Hill 1 Durham COUNTY Carrboro UNC - 540 54 40 RTP Chapel Hill 401 70

540 Raleigh

Morrisville 440

55 54 40 Meredith William Peace College University 15 501 St. AugustinesCollege Cary NC State 64 University Shaw CHATHAM Jordan Lake 540 University COUNTY 64 Apex Pittsboro 1 40 Garner

70 REGIONAL MAP Wake Tech 3 SERVICE PROVIDERS

Bank of America First Environments Early Learning Center www.bankofamerica.com 2 Park Drive www.firstenvironments.org 109 T.W. Alexander Drive MD-FE-105 P.O. Box 13804 Research Triangle Park, NC 27709 (919) 956-2248 (919) 541-1361 Research Triangle Park, NC 27709

Bright Horizons at RTP RTP Federal Credit Union www.brighthorizons.com/rtp 2352 So-Hi Drive www.rtpfcu.org 21 Park Drive Research Triangle Park, NC 27709 Research Triangle Park, NC 27709 (919) 483-6713 (919) 941-5700 @brighthorizons Bright Horizons at The Enrichment Center Triangle Ultimate www.brighthorizons.com/enrich- www.triangleultimate.org The Frontier ment 10 T.W. Alexander Drive 800 Park Offices Drive 919-907-1279 P.O. Box 12726 Research Triangle Park, NC 27709 (919) 549-4802 Research Triangle Park, NC 27709 @TriangleUtly First Citizens Bank United States Postal Service www.firstcitizens.com 22 Park Drive www.usps.gov 65 T.W. Alexander Drive P.O. Box 12203 P.O. Box 9998 (919) 549-8671 (800) 275-8777 Research Triangle Park, NC 27709 Research Triangle Park, NC 27709 Wells Fargo www.wellsfargo.com 4 Park Drive P.O. Box 12078 (919) 549-8621 Research Triangle Park, NC 27709 RTP Companies By Size Incubators and Accelerators 64% 1 - 9 Employees Alexander Business Suites 13% 10 - 24 Employees Alexandria Innovation Center 4% 25 - 49 Employees First Flight Venture Center 6% 50 - 99 Employees The Frontier 4% 100 - 249 Employees The Lab 4% 250 - 999 Employees 4% 1,000 - 4,999 Employees Service Providers are business and institutions in the Research Triangle Park which 1% 5,000+ Employees support RTP companies but are not involved in scientific research. 4 COMPANY LISTINGS # A

21st Century Creations (919) 354-1001 Headquarters www.21centurycreations.com Research Triangle Park, North First Flight Venture Center Carolina 21st Century Creations is an umbrella operation that oversees the development of start-up 2 Davis Drive and early stage companies. Services provided include strategic development, product Research Triangle Park, NC Business and Professional development, financial support and access to a team of professional advisors. For those 27709 Services inventors and would-be entrepreneurs who have a great idea but not the time, money or In RTP since 2011 expertise to help it become a reality, we are here to help. Under 50 employees

Aerie Pharmaceuticals, Inc (908) 470-4320 Headquarters www.aeriepharma.com Bedminster, NJ Alexandria Innovation Center Aerie Pharmaceuticals, Inc. is a privately held, clinical stage biotechnology company 7020 Kit Creek Road Biotechnology/Life Sciences developing a portfolio of innovative medications to treat patients suffering from eye Suite 270 Pharmaceuticals/Diagnostics diseases. The company is a spin-out of Duke University Medical Center. Research Triangle Park, NC Under 50 employees 27709

AgTech Accelerator Corporation 7020 Kit Creek Road Headquarters Research Triangle Park, NC Research Triangle Park, North www.agtechaccelerator.com 27709 Carolina AgTech Accelerator™ is a unique startup accelerator focused on discovering and developing emerging agricultural technology companies. Ascent Bio-Nano Technologies: Business and Professional Ascent Bio-Nano Technologies, Inc. is a research spin-off from the Pennsylvania State Services University formed in 2012. We moved to First Flight Venture Center at Research Triangle In RTP since 2016 Park, NC in 2016. Under 50 employees

Inspiring bold ideas™ 5 AgBiome The Lab Headquarters 104 T.W. Alexander Drive Research Triangle Park, North www.agbiome.com Building 1 Carolina A AgBiome provides industry-leading discovery and early research for agriculture. P.O. Box 14069 Research Triangle Park, NC Agricultural Biosciences 27709 In RTP since 2013 50-99 employees

Agile EndoSurgery (919) 354-1073 Headquarters Research Triangle Park, North www.agileendosurgery.com First Flight Venture Center Carolina Agile EndoSurgery develops laparoscopic surgical instruments that bridge the gap 2 Davis Drive between robotic assistive devices and conventional minimally invasive surgical devices. Suite 132 Medical Devices and Instruments Research Triangle Park, NC In RTP since 2012 27709 Under 50 employees

Alera Labs LLC (919) 228-8209 Headquarters www.aleralabs.com Research Triangle Park, North The Lab Carolina Alera Labs is a contract research organization (CRO) providing analytical and pre- 104 T.W. Alexander Drive formulation support to small and mid-size pharmaceutical, biotech and medical device Building 3 Biotechnology/Life Sciences companies. Alera Labs was founded in 2010 after the realization that most larger CROs P.O. Box 13019 Pharmaceuticals and Diagnostics are not able to accommodate the needs of the small startup companies requiring faster Research Triangle Park, NC In RTP since 2013 response times and operating out of much smaller budgets. 27709 Under 50 employees

Alexander Business Suites (919) 314-2813 Headquarters www.AlexanderRTP.com Research Triangle Park, North 68 T.W. Alexander Drive Carolina Alexander Business Suites (ABS) provides office space and services within a professional P.O. Box 13628 environment within Research Triangle Park. ABS was structured to be an environment Research Triangle Park, NC Business and Professional where smaller businesses--or larger businesses with needs to house smaller groups-- 27709 Services could operate within RTP. ABS can accommodate companies needing anything from a In RTP since 2010 single office to dozens. ABS includes high speed internet, printers, conference rooms, Under 50 employees telephones and much more directly in its reasonable base rates, and structures its leases on a flexible short term basis. This type of arrangement was missing from RTP and ABS was established to fill this need. ABS is locally owned and operated.

Inspiring bold ideas™ 6 Alion Science and Technology Corporation 5 Triangle Drive Headquarters www.alionscience.com P.O. Box 12313 McLean, Virginia Research Triangle Park, NC A Alion Science and Technology Corporation is an employee-owned technology solutions 27709 Biotechnology/Life Sciences company delivering technical expertise and operational support to the Department of In RTP since 1973 Defense, civilian government agencies and commercial customers. Alion was formed in 50 - 99 employees December 2002, and acquired ManTech Environmental Technology, Incorporated in 2005.

All About Beer, LLC The Frontier Headquarters 800 Park Offices Drive Research Triangle Park, North www.allaboutbeer.com Suite 3223 Carolina All About Beer Magazine is America’s leading beer magazine, dedicated to covering the P.O. Box 110346 people, places, news, trends and events that define the beer community. For 37 years, it’s Research Triangle Park, NC Information Technology been our mission to celebrate the world of beer culture and enrich the lives of beer lovers 27709 In RTP since 2016 through education, enjoyment and events like the World Beer Festivals. Under 50 employees

American Association of Textile Chemists and Colorists (919) 549-8141 Headquarters Research Triangle Park, North (AATCC) One Davis Drive Carolina www.aatcc.org P.O. Box 12215 The American Association of Textile Chemists and Colorists (AATCC) is the world’s largest Research Triangle Park, NC Foundations, Institutes and technical and scientific society devoted to the advancement of textile chemistry, design 27709 Scientific Associations and materials. The Association has 2,000-plus individual and more than220 corporate In RTP since 1964 members in about 60 countries. The Association is best known for its test methods, used Under 50 employees globally, to assess textile materials and garments. AATCC also conducts training and educational programs, publishes a journal, magazine, newsletter and other informative pieces from time to time, and has established the separate public charitable AATCC Foundation, Inc. providing scholarships and research grants to worthy students.

Arbiom TUCASI Headquarters www.arbiom.com 15 T.W. Alexander Drive Research Triangle Park, NC Biotechnology/Life Sciences Arbiom is pioneering the development and commercialization of new technologies for 27709 In RTP since 2015 the transformation of renewable non-food feedstock to biocompatible sugars and high- Under 50 employees grade lignin needed for the renewable chemicals and advanced biomaterials industries. By unlocking new, high-value opportunities for abundant, renewable biomass to provide bio-based chemicals and materials industries with more environmentally friendly choices, Arbiom is becoming the enabler of the sustainable bioeconomy.

Inspiring bold ideas™ 7 Army Research Office (919) 549-0641 Headquarters Research Triangle Park, North www.arl.army.mil/www/default.cfm?page=29 The Frontier Carolina A The U.S. Army Research Laboratory’s Army Research Office (ARO) mission is to serve 800 Park Offices Drive as the Army’s principal extramural basic research agency in the engineering, physical, P.O. Box 12211 Foundations, Institutes and information and life sciences; developing and exploiting innovative advances to insure the Research Triangle Park, NC Scientific Associations Nation’s technological superiority. Basic research proposals from educational institutions, 27709 In RTP since 2016 nonprofit organizations, and private industry are competitively selected and funded. ARO’s Under 50 employees research mission represents the most long-range Army view for changes in its technology. ARO priorities fully integrate Army-wide, long-range planning for research, development, and acquisition. ARO executes its mission through conduct of an aggressive basic science research program on behalf of the Army so that cutting-edge scientific discoveries and the general store of scientific knowledge will be optimally used to develop and improve weapons systems that establish land force dominance.

Ascent Bio-Nano Technologies First Flight Venture Center Headquarters 2 Davis Drive Research Triangle Park, North www.ascentbionano.com Research Triangle Park, NC Carolina 27709 Biotechnology/Life Sciences In RTP since 2016 Under 50 employees

Atlantic Pharmaceuticals Ltd 15 T.W. Alexander Drive Global Headquarters Research Triangle Park, NC Saffron Walden, UK wwww.atlantichc.com 27709 Biotechnology/Life Sciences In RTP since 2016 Under 50 employees

Attagene, Inc. (919) 593-0292 Headquarters www.attagene.com Research Triangle Park, North Alexandria Innovation Center Carolina Attagene, Inc. was founded in 2001. The company’s mission is to accelerate drug 7020 Kit Creek Road, discovery and development by providing innovative tools for examining signal Suite 260 Medical Devices and Instruments transduction. Research team scientists have both academic and industrial backgrounds P.O. Box 12054 In RTP since 2002 that combine expertise in signal transduction, functional genomics and gene discovery Research Triangle Park, NC Under 50 employees with knowledge of disease pathology. 27709

Inspiring bold ideas™ 8 Avazyme, Inc (508) 317-2287 Headquarters www.avazyme.com Research Triangle Park, North The Lab Carolina A Avazyme is a solution provider offering field and laboratory testing under GLP (EPA, FDA, 104 T.W. Alexander Drive OECD), product development, and expert consulting services to the agriculture and food Building 4 Biotechnology/Life Sciences B industries, craft brewers, wineries, and distillers. Avazyme’s comprehensive services Research Triangle Park, NC Agricultural Biosciences include food safety analyses for contaminants, pathogens, allergens, food quality and 27709 In RTP since 2015 nutrition analysis, genetic trait testing, protein quantification, and preparation of regulatory Under 50 employees submission data packages. Capabilities include analytical chemistry and immunochemistry, mass spectrometry, microbiology, and molecular biology. These services are complemented by the development of innovative point-of-use tests and novel diagnostic solutions, providing fast and reliable answers to ensure food safety and food quality for everyone.

Avertica (919) 354-1056 Headquarters www.averticainc.com Research Triangle Park, North First Flight Venture Center Carolina Avertica is an early stage start-up company developing novel compounds and 2 Davis Drive polymers for electronic device applications. Many of our compounds and polymers are Research Triangle Park, NC Medical Devices and Instruments inspired by naturally occurring chemicals and biological polymers. We have developed 27709 In RTP since 2012 inexpensive, simple methods for producing linear conjugated polymers and polymer Under 50 employees networks with diverse properties. These compounds and polymers may have uses in diverse applications including touchscreen applications, organic light emitting diodes, solar collectors, light detection, memory devices, molecular electronic applications and supercapacitors for energy storage.

Avioq, Inc. (919) 314-5535 Headquarters www.avioq.com Research Triangle Park, North The Lab Carolina Avioq, Inc., founded in 2007 and incorporated in North Carolina, has headquarters in 104 T.W. Alexander Drive, Research Triangle Park, NC. The Management Team has over 250 years of experience in Building 6 Pharmaceuticals and Diagnostics the diagnostics industry. The company’s current products include an FDA approved HIV-1 P.O. Box 12808 In RTP since 2008 assay (a Class III device), an FDA licensed HTLV-I/II assay for screening serum and plasma Research Triangle Park, NC Under 50 employees from blood donor, and cadaveric samples, which also has CE marking and Health Canada 27709 approval. The company offers contract research, development and manufacturing for diagnostic test kits and critical biomaterials to third parties.

Inspiring bold ideas™ 9 AXA Advisors (919) 316-1300 US Headquarters www.axa-equitable.com New York, New York One Park Drive Global Headquarters A AXA Advisors, LLC has been helping individuals and businesses in the Research Triangle Suite 110 Paris, France Region and eastern North Carolina address their financial goals for over 100 years. P.O. Box 14767 B Research Triangle Park, NC Financial Services and 27709 Technologies In RTP since 2003 Under 50 employees

BA3 LLC (919) 341-4415 Headquarters Research Triangle Park, North www.ba3.us The Frontier Carolina BA3 creates technology for mapping applications, including Atlus products. 800 Park Offices Drive 3rd Floor, P.O. Box 37613 Information Technology Research Triangle Park, NC In RTP since 2016 27709 Under 50 employees

BaseTrace (919) 354-1016 Headquarters www.basetrace.com Research Triangle Park, North First Flight Venture Center Carolina BaseTrace produces DNA-based tracers for source-specific fluid tracking applications in 2 Davis Drive multiple industries, including hydraulic fracturing (fracking), power generation, wastewater P.O. Box 13169 Clean and Green Technologies services, and hydrogeology. This technology represents a cutting-edge tracing solution Research Triangle Park, NC In RTP since 2012 capable of assigning a unique ID to individual fluid sources, providing a powerful tool 27709 Under 50 employees for leak detection, optimization, and risk assessment. BaseTrace was founded in 2012 by Justine Chow, CEO, Jake Rudulph, CTO, Paul-Harvey Weiner, Adam Rigel, and David Roche. BaseTrace is headquartered in the First Flight Venture Center.

BASF Corporation (919) 547-2000 US Headquarters www.basf.com Florham Park, New Jersey 26 Davis Drive Global Headquarters The BASF RTP site is home to the BASF Corporation Crop Protection business and is the P.O. Box 13528 Ludwigshafen, Germany headquarters for the BASF North American Crop Protection Division; BASF Plant Science, Research Triangle Park, NC LLC; BASF Global Insecticide Research; and BASF Global Agricultural R&D. BASFCrop 27709 Biotechnology/Life Sciences Protection markets a range of innovative crop protection materials and systems that Agricultural Biosciences enable growers to increase their cost efficiency as well as their crop yield potential. It also In RTP since 1986 supplies a variety of innovative weed and pest control productsused to solve problems in turf, ornamental, forestry and public health markets. 1,000 - 4,999 employees

Inspiring bold ideas™ 10 Bayer CropScience (919) 549-2000 US Headquarters www.bayerus.com Research Triangle Park, North 2 T.W. Alexander Drive Carolina Bayer CropScience researches, develops, manufactures and sells a broad range of P.O. Box 12014 Global Headquarters innovative crop science products for the crop protection, biotechnology and seed Research Triangle Park, NC Monheim, Germany B markets; the turf and ornamental and professional pest management markets; and the 27709 consumer lawn and garden markets. Bayer CropScience, with worldwide headquarters in Biotechnology/Life Sciences Monheim, Germany, is a business area within the worldwide Bayer Group. The Research Agricultural Biosciences Triangle Park is the business headquarters of the company’s NAFTA Region.

BD Technologies (919) 549-8641 Headquarters www.bd.com Franklin Lakes, New Jersey 21 Davis Drive BD Technologies is the corporate technology R&D center for Becton Dickinson and P.O. Box 12016 Medical Devices and Instruments Company (BD). Established in 1972, the organization is responsible for technology Research Triangle Park, NC In RTP since 1973 sourcing, evaluation, feasibility and development activities, typically in a highly 27709 250 - 499 employees collaborative environment with external corporate, academic and government partners. BD Technologies focuses on developing high-value business opportunities in the following fields: parenteral drug delivery, new diagnostic platforms, advanced diabetes technologies, and cell and tissue engineering.

Benson Hill Biosystems, Inc. Alexandria Innovation Center Headquarters www.bensonhillbio.com 7020 Kit Creek Road Research Triangle Park, North Suite 250 Carolina Benson Hill Biosystems is an agricultural biotechnology company focused on the P.O. Box 13487 development of biotech-based traits to increase intrinsic crop yield. Research Triangle Park, NC Agricultural Biosciences 27709 In RTP since 2013 Under 50 employees

BHV Pharma, Inc. 3200 NC Highway 54 Headquarters www.bhvpharma.com Suite 100 Research Triangle Park, North P.O. Box 13765 Carolina BHV was launched with the mission to develop novel therapeutics aimed at improving the Research Triangle Park, NC lives of patients suffering from metabolic disorders, including diabetes and NASH/NAFLD. 27709 Pharmaceuticals and Diagnostics The company’s lead development program is in Phase 2 development for Type 2 Diabetes. In RTP since 2009 Under 50 employees

Inspiring bold ideas™ 11 BindusChem (919) 558-1201 Headquarters www.binduschem.com Research Triangle Park, North 6 Davis Drive Carolina BindusChem, LLC is a chemistry-based contract research service organization with a core Suite 230 business of custom synthesis. The company offers a variety of synthetic chemistry services Research Triangle Park, NC Biotechnology/Life Sciences B (from mg to kg quantities) to customers in a cost-effective and timely manner, specializing 27709 In RTP since 2014 in small molecules, porphyrins, nucleosides and nucleotides, and heterocycles. Under 50 employees BindusChem binds to customer focus, reliability and confidentiality.

Biogen (919) 993-1100 US Headquarters www.biogen.com Cambridge, Massachusetts 5000 Davis Drive Global Headquarters Through cutting-edge science and medicine, Biogen discovers, develops and delivers to P.O. Box 14627 Zug, Switzerland patients worldwide innovative therapies for the treatment of neurodegenerative diseases, Research Triangle Park, NC hematologic conditions and autoimmune disorders. Founded in 1978, Biogen is the world’s 27709 Biotechnology/Life Sciences oldest independent biotechnology company and patients worldwide benefit from its In RTP since 1995 leading multiple sclerosis and innovative hemophilia therapies. The company established 1,000-4,999 employees operations in RTP in 1995 and today has more than 1,300 employees inmanufacturing and patient services. bioMASON 12 T.W. Alexander Drive Headquarters www.biomason.com Building 200, Suite B Research Triangle Park, North Carolina bioMASON develops masonry material from a non-pathogenic bacterium, which induces Research Triangle Park, NC cement materials in between aggregates such as sand. 27709 Clean and Green Technologies In RTP since 2013 Under 50 employees

BioMedomics, Inc. (919) 558-1210 Headquarters www.biomedomics.com Research Triangle Park, North 6 Davis Drive Carolina BioMedomics, Inc. develops test reagents, devices and instruments for rapid personalized P.O. Box 14433 medicine diagnostics applications. Research Triangle Park, NC Medical Devices and Instruments 27709 In RTP since 2006 bioMONTR Labs (866) 609-3870 Headquarters www.bioMONTR.com Research Triangle Park, North The Lab Carolina bioMONTR is an infectious disease laboratory specializing in assay and drug development 104 T.W. Alexander Drive, with an emphasis on molecular diagnostics primarily focusing on clinical utility of molecular Building 7 Pharmaceuticals and Diagnostics testing within infectious disease therapeutic areas. bioMONTR employees have over P.O. Box 12565 In RTP since 2010 50 collective years of expertise in design, validation and performance of nucleic acid Research Triangle Park, NC Under 50 employees extraction systems, ASRs, real-time viral load and sequencing assays for viral pathogens in 27709 pharmaceutical and IVD trials for both pre- and post-approval applications.

Inspiring bold ideas™ 12 BioShape Solutions (919) 789-1383 Headquarters www.bioshapesolutions.com Research Triangle Park, North First Flight Venture Center Carolina BioShape Solutions has developed novel medical devices that provide simple and 2 Davis Drive effective local delivery of therapeutic agents to inhibit and treat infection around surgical P.O. Box 13169 Medical Devices and Instruments B implants. BioShape’s devices are truly unique and are designed to easily and securely Research Triangle Park, NC In RTP since 2010 attach to fixation implants (metal plates or rods) during surgery. The devices enable 27709 Under 50 employees immediate and sustained local delivery of a preventive/therapeutic medical agent. Initially, BioShape is focusing on devices used in fracture repair and spinal fusion for both human and animal markets.

Blackstone Entrepreneurs Network The Frontier Headquarters www.bennorthcarolina.com 800 Park Offices Drive New York, New York Suite G302 Blackstone Entrepreneurs Network was launched in North Carolina in 2011 with a gift from Research Triangle Park, NC Business and Professional The Blackstone Charitable Foundation. The Network’s mission is to help catalyze the 27709 Services regional development of the Triangle’s entrepreneurial ecosystem and thereby strengthen In RTP since 2015 economic development in the area. Under 50 Employees

BlocLedger Inc (919) 371-8306 Headquarters Research Triangle Park, North www.blocledger.com The Frontier Carolina BlocLedger provides blockchain product and services in support of Hyperledger Fabric. 800 Park Offices Drive The company partners with enterprise customers in their evaluation, implementation and Suite 3706 Information Technology deployment of blockchain solutions based on Hyperledger. Customized utilities, APIs Research Triangle Park, NC In RTP since 2015 and operational dashboards provided by BlocLedger enable seamless integration of 27709 Under 50 employees blockchain technology into a company’s existing work flows and application infrastructure. The company has integrated third party e-Signature solutions with blockchain to provide an auditable time stamped proof of the data’s integrity and existence which can be verified without relying on a trusted authority.

Bluecell Energy First Flight Venture Center Headquarters www.bluecellenergy.com 2 Davis Drive Research Triangle Park, North P.O. Box 13169 Carolina Bluecell Energy, LLC is a North Carolina startup developing a novel rechargeable battery Research Triangle Park, NC system to provide cost-effective energy storage services to the electric grid. 27709 Clean and Green Technologies In RTP since 2013 Under 50 employees

Inspiring bold ideas™ 13 Brite Bio, Inc. 3200 NC Highway 54 Headquarters www.britebio.com Suite 100 Research Triangle Park, North P.O. Box 13888 Carolina Brite Bio is a woman owned small business. Formed in 2012 by Dr. Renee Lea-Currie, Research Triangle Park, NC our mission is to provide the highest quality human cell systems, reagents and contract 27709 Biotechnology/Life Sciences B services to our research partners; to develop and commercialize innovative research In RTP since 2009 C tools, leverage our expertise through research and development and strategic alliances Under 50 employees that accelerate discovery.

Bunker Labs RDU (919) 656-4434 Headquarters www.bunkerlabsrdu.org Chicago, IL The Frontier We are a national program built by veteran entrepreneurs, for veteran entrepreneurs. 800 Park Offices Drive Business and Professional We believe veterans are our greatest national human asset - we aim to inspire, educate, P.O. Box 13901 Services and connect them to fulfill their potential. Our Mission: “To catalyze the entrepreneurial Research Triangle Park, NC In RTP since 2015 potential of the military experience to lead innovation in the American economy”. 27709 Under 50 employees

Burroughs Wellcome Fund (919) 991-5100 Headquarters www.bwfund.org Research Triangle Park, North 21 T.W. Alexander Drive Carolina The Burroughs Wellcome Fund is an independent private foundation dedicated to P.O. Box 13901 advancing the biomedical sciences by supporting research and other scientific and Research Triangle Park, NC Foundations, Institutes and educational activities. 27709 Scientific Associations In RTP since 1970 Under 50 employees

Camras Vision First Flight Venture Center Headquarters www.camrasvision.com 2 Davis Drive Research Triangle Park, North Research Triangle Park, NC Carolina Camras Vision is an ophthalmic medical device company developing a solution for 67 27709 million glaucoma sufferers.

Cell Microsystems (252) 285-9842 Headquarters www.cellmicrosystems.com Research Triangle Park, North First Flight Venture Center Carolina Cell Microsystems was founded in 2010 to develop and commercialize the CellRaft 2 Davis Drive System. The technology behind the CellRaft System was developed in the lab of Dr. Nancy P.O. Box 13169 Biotechnology/Life Sciences Allbritton at the University of North Carolina, Chapel Hill. Cell Microsystems focuses its Research Triangle Park, NC In RTP since 2015 product development and commercialization on ‘product applications’ for its technology. 27709 Under 50 employees The company and its collaborators and early adopters have developed an expansive list of product applications where the CellRaft System provides a crucial step in the sample preparation workflow that is agnostic to the investigators chosen molecular analysis method (i.e. qPCR, NGS, etc.) or source of reagents.

Inspiring bold ideas™ 14 Centauri Surgical Systems First Flight Venture Center Headquarters 2 Davis Drive Research Triangle Park, North www.centaurisurgical.com Research Triangle Park, NC Carolina Centauri Surgical Systems is a medical device company that develops real-time MRI 27709 guided robotic surgical platforms for neurologic procedures that allow surgeons to Biotechnology/Life Sciences precisely access the brain and spine during surgery providing rapid, automated delivery In RTP since 2016 C of diagnostic and therapeutic instruments and drugs. These platforms are fast, accurate, Under 50 employees and can facilitate 3-D image guided procedures including deep brain stimulation, tumor ablation, biopsy, lesion removal, and electrode device placement representing a significant breakthrough over existing methods.

Center for Innovation Management Studies The Frontier Headquarters www.cims.ncsu.edu 800 Park Offices Drive Raleigh, North Carolina Research Triangle Park, NC @CIMS_NCSU 27709 Business and Professional The Center for Innovation Management Studies (CIMS) represents a one-of-a-kind Services convergence of academia and industry. Its purpose is to study technological innovation In RTP since 2015 and its management, disseminate that knowledge, and help companies apply it to achieve Under 50 employees bottom-line results. CIMS is dedicated to fostering a collaborative environment among scholars, researchers and business executives. Its location helps advance this mission: CIMS is housed in the College of Management at NC State University’s Centennial Campus, located in the vibrant, technology-rich Research Triangle Park region of North Carolina.

Center for International Understanding (919) 314-2826 Headquarters ciu.northcarolina.edu Research Triangle Park, North Alexander Business Suites Carolina The Center for International Understanding serves North Carolina by promoting 68 T.W. Alexander Drive awareness, expanding understanding, and empowering action through global education. P.O. Box 13628 Foundations, Institutes and CIU’s programs for business, policy and education leaders aim to make North Carolina the Research Triangle Park, NC Scientific Associations most globally engaged state in the nation. 27709 In RTP since 2014 Under 50 employees

Centers for Disease Control and Prevention (919) 541-1317 Headquarters www.cdc.gov Atlanta, Georgia 3210 NC Highway 54 The Centers for Disease Control and Prevention (CDC) - National Center for Health Catawaba Building Biotechnology/Life Sciences Statistics works to protect public health and safety by providing information to P.O. Box 12214 In RTP since 2008 enhance health decisions, and it promotes health through partnerships with state Research Triangle Park, NC 100 - 249 employees health departments and other organizations. The CDC focuses national attention on 27709 developing and applying disease prevention and control (especially infectious diseases), environmental health, occupational safety and health, health promotion, prevention and education activities designed to improve the health of the people of the United States.

Inspiring bold ideas™ 15 CertiRx Corporation (919) 354-1029 Headquarters www.certirx.com Research Triangle Park, North First Flight Venture Center Carolina CertiRx Corporation is developing CertiTag(TM) Assured Brands(TM) and TraxSecur(TM) 2 Davis Drive Serialized Security(TM) to make pharmaceutical products safer from the growing global P.O. Box 13169 Information Technology risk of counterfeiting. Additionally, CertiRx Corporation’s anticounterfeiting and security Research Triangle Park, NC In RTP since 2010 C technology platform has many applications outside of pharmaceuticals, including 27709 Under 50 employees AuthentiForm(TM) sensitive document security solutions.

Chaperone Therapeutics, Inc. 6 Davis Drive Headquarters www.chaperonetherapeutics.com P.O. Box 12167 Research Triangle Park, North Research Triangle Park, NC Carolina Chaperone Therapeutics, Inc. is an early-phase pharmaceutical company founded to 27709 develop therapies for diseases associated with protein misfolding by restoring the body’s Pharmaceuticals and Diagnostics natural balance of the protein folding activity.

ChemoGenics BioPharma (919) 323-8133 Headquarters www.chemogenicsbiopharma.com Research Triangle Park, North The Lab Carolina As a drug discovery research and service based organization, ChemoGenics BioPharma 104 T.W. Alexander Drive strives to be the partner of choice for solutions to multiple aspects of the drug discovery Building 7 Pharmaceuticals and Diagnostics process. We have consistently delivered exceptional value to both large and small Research Triangle Park, NC In RTP since 2010 research laboratories, our client satisfaction is measured by a large number (>90%) of 27709 Under 50 employees repeat clients. We have state of the art facilities such as two LC/MS/MS, ELSD, GCMS, Prep HPLC, and CEM discovery explorer. We have successfully generated chemical composition of matter for companies that don’t have in-house chemistry capabilities. Since our inception, we have completed several multi-year long FTE-based projects.

ChemQ Bioscience LLC (919) 230-1617 Headquarters www.vitroprep.com Research Triangle Park, North 6 Davis Drive Carolina ChemQ Bioscience LLC, a privately owned research and development company focusing Research Triangle Park, NC on manufacturing of in vitro diagnostic products, was incorporated in the State of North 27709 Pharmaceuticals and Diagnostics Carolina, USA. The founder, members and scientific advisory board of the company have In RTP since 2013 many years of experience in medicinal chemistry, clinical oncology, clinical pathology and Under 50 employees molecular biology.

Inspiring bold ideas™ 16 Ciena Corporation (800) 207-3714 Headquarters www.ciena.com Hanover, Maryland One Park Drive Ciena Corporation, the network specialist, offers leading network infrastructure, Suite 300 Information Technology intelligent software, and comprehensive services to help operators, enterprises, and Research Triangle Park, NC In RTP since 2010 governments exploit the full potential of their networks and fundamentally change the 27709 Under 50 employees way they compete. Ciena leverages deep expertise in packet and optical networking C and distributed software to deliver solutions in alignment with OPn, its architecture for next-generation networks that are programmable, scalable, and can automatically adapt to handle the changes created by the surging demand for high-bandwidth applications and services. The company’s solutions form the foundation of many of the largest, most reliable and sophisticated networks across the globe.

Cisco Systems, Inc. (919) 392-2000 Headquarters www.cisco.com San Jose, California 7025 Kit Creek Road Cisco is the worldwide leader in networking that transforms how people connect, P.O. Box 14987 Information Technology communicate and collaborate. Research Triangle Park, NC In RTP since 1995 27709 5,000+ employees

Clairvoyant Networks LLC First Flight Venture Center Headquarters 2 Davis Drive Research Triangle Park, North www.theoracare.com Research Triangle Park, NC Carolina Clairvoyant Networks LLC is focused on leveraging technologies to improve the lives 27709 of aging in place, independent living and memory care seniors, their loved ones and Biotechnology/Life Sciences professional care providers by implementing simple to use cost effective solutions and In RTP since 2016 services. Under 50 employees

Cleanvolt Energy First Flight Venture Center Headquarters Research Triangle Park, North CleanVolt Energy develops advanced super-capacitor/battery technology for mobile 2 Davis Drive products. The company is dedicated to the development of novel battery materials Research Triangle Park, NC Carolina with high storage capacity to enable cost-effective electric cars, mobile devices and 27709 the storage of solar energy for the enablement of a greener world with the ability to Clean and Green Technologies outperform current batteries x5. In RTP since 2016 Under 50 employees

Inspiring bold ideas™ 17 Clinical Ambassador (919) 410-7783 Headquarters Research Triangle Park, North www.clinicalambassador.com The Frontier Carolina Clinical Ambassador is a patient recruitment marketing agency that promotes widespread 800 Park Offices Drive awareness of and access to clinical research. We are status quo disruptors who use Suite 3750 Business and Professional humor, honesty and humanity in our dynamic tactics to address health disparities and P.O. Box 13604 Services C gaps in representation with the ultimate goal of engaging more diverse participants. Our Research Triangle Park, NC In RTP since 2017 realistic strategies support meaningful multicultural inclusion to reflect the “Browning of 27709 Under 50 employees America” and optimize outcomes for all concerned.

Clinical Sensors, Inc. First Flight Venture Center Headquarters 2 Davis Drive Research Triangle Park, North Clinical Sensors is commercializing sensors to improve monitoring and care for serious Research Triangle Park, NC Carolina medical conditions such as diabetes, chronic wounds, and infection. The membrane-based 27709 platform technologies being developed by Clinical Sensors greatly enhance the specificity, accuracy, and analytical performance of electrochemical sensors both in vivo and ex vivo. Medical Devices and Instruments Clinical Sensors is poised to significantly transform patient care by providing accurate, In RTP since 2014 rapid, and actionable results for analytes that, untilrecently, were challenging to measure. Under 50 employees

Cloud Pharmaceuticals, Inc. (919) 424-6894 Headquarters www.cloudpharmaceuticals.com Research Triangle Park, North 6 Davis Drive Carolina Cloud Pharmaceuticals is changing the way drugs are discovered and developed. Research Triangle Park, NC Cloud Pharmaceuticals designs new drugs and drug candidates and accelerates the 27709 Pharmaceuticals and Diagnostics development process by implementing new, innovative cloud computing technology In RTP since 2012 in place of traditional methods. We manage development of multiple assets through an Under 50 employees extensive network of partners. This reduces cost, decreases development time, and creates novel molecules with therapeutic value. Our drug discovery and development implementation consists of a drug design technology called Inverse Design that uses high-performance cloud computing resources, followed by immediate preclinical optimization and rapid development toward Investigational New Drug (IND) and Phase 1. We have a growing pipeline including central nervous system (CNS), cancer, inflammation, lipid metabolism, and rare disease indications, among others.

CNanoz Inc. 919-354-1071 Headquarters Research Triangle Park, North www.cnanoz.com First Flight Venture Center Carolina CNanoz is an innovator in developing nano technology based water purification systems. 2 Davis Drive CNanoz’s strategy is to bring innovative, nano technology based products to market Research Triangle Park, NC Biotechnology/Life Sciences by developing and marketing high utility carbon, silver, ferric and alumina based nano 27709 In RTP since 2015 materials. Our hybrid nano system consists of carbon, silver, ferric and alumina whose Under 50 employees proportions are customizable dependent on the water quality to trap all biological organic and inorganic toxic materials. This hybrid filter of nano materials can be used for water purification for safe human consumption through removal of pathogens and toxic materials such as Sulphate, Arsenic, Fluoride, Lead and Cadmium.

Inspiring bold ideas™ 18 Compass Datacenters (877) 289-7577 Headquarters www.compassdatacenters.com Dallas, Texas 99 T.W. Alexander Drive Compass Datacenters is a wholesale provider focused on delivering dedicated data Research Triangle Park, NC Information Technology centers for businesses seeking 1MW to 3MW day one of IT load capacity with the ability 27709 In RTP since 2013 for future growth in the location of their choice. Your Compass data center is untethered Under 50 employees from geographic constraints and capacity planning obstacles to provide you with greater C control and a cost model that directly links your spending to your growth. Best of all, unlike other providers, everything is included.

Connecture Inc. (262) 432-8282 Headquarters www.connecture.com Brookfield, Wisconsin Alexander Business Suites Our singular focus on health insurance distribution allows us to offer true end-to-end 68 T.W. Alexander Drive Business and Professional solutions for every market segment: state, federal, and commercial – for members under Research Triangle Park, NC Services the age of 65 and over. For today’s changes and tomorrow’s, Connecture is ready. With 27709 In RTP since 2014 the technology and user experience insights you need to reach more markets – more Under 50 employees efficiently and more effectively.

Copernicus Group IRB (919) 465-4310 Headquarters www.cgirb.com Research Triangle Park, North One Triangle Drive Carolina Established in 1996 as an independent institutional review board (IRB), Copernicus Group Suite 100 IRB’s (CGIRB) 28 board members meet twice weekly to carry out full board reviews. P.O. Box 110605 Biotechnology/Life Sciences Expedited reviews are completed on a daily basis. CGIRB provides review of drug, Research Triangle Park, NC In RTP since 2007 device, biologic and social-behavioral studies for FDA and OHRP regulated research 27709 50 - 99 employees for sponsors, CROs and institutions. CGIRB was awarded full accreditation of the human research protection program by The Association for the Accreditation of Human Research Protection Programs, Inc., and was awarded full reaccreditation in 2007.

Couragen Biopharmaceutics, LLC (919) 558-1208 Headquarters Research Triangle Park, North Couragen Biopharmaceutics, LLC is a North Carolina startup biotechnology company 6 Davis Drive Carolina whose mission is to develop gene therapy and protein therapy products for pre-clinical Suite 234 and clinical use. Couragen uses a technology platform based on adeno-associate virus (AAV) vectors, a safe and powerful vehicle, to deliver therapeutic genes to a variety Research Triangle Park, NC Pharmaceuticals and Diagnositics of cells, tissues and even the whole body for genetic and chronic diseases treatment. 27709 In RTP since 2014 In addition, the company also provides custom-designed AAV vectors, which are in Under 50 employees high demand as a tool for laboratory research such as molecular biology, genetics and mechanisms of pathogenesis and even engineering of animal models.

Inspiring bold ideas™ 19 CraZBrain, LLC (919) 357-2200 Headquarters www.crazbrain.com Research Triangle Park, North The Frontier Carolina CraZBrain, LLC was founded by Aaron Rothrock to make science fun and exciting for 800 Park Offices Drive, elementary and middle school aged students. Aaron earned his Ph.D. in chemistry at 4th Floor Business and Professional the University of North Carolina at Chapel Hill and taught middle school science at Cary Research Triangle Park, NC Services C Academy until 2014. His strong science background combined with years of teaching 27709 In RTP since 2014 experience has inspired him to form CraZBrain to convert the historically mundane Under 50 employees curriculum to one which brings science to life, allowing students to think, design, experiment and desire to repeat. His history of converting kids from saying “I’ve never really liked science” into “Science is my favorite subject” speaks for itself!

Creative PEGWorks (919) 357-2200 Headquarters Research Triangle Park, North www.creatovepegworks.com The Lab Carolina Creative PEGWorks manufactures and sells advance polymer products to support R&D in 104 T.W. Alexander Drive biomedical engineering, pharmaceuticals, regenerative medicine, drug delivery, medical Suite 505 Biotechnology/Life Sciences device and other biotechnology and nanotechnology applications. Its main product lines Research Triangle Park, NC In RTP since 2007 include PEGylation reagents, PEG copolymers, functional biopolymers, hualuronic acid 27709 Under 50 employees among others. PEGWorks also provides contract research and consulting services.

Creative Scientist The Lab Headquarters 104 T.W. Alexander Drive Research Triangle Park, North www.incellbio.com Suite 5-11 Carolina Creative Scientist, Inc., an investigative cell biology company, develops advanced Research Triangle Park, NC cell-based assays to analyze both individual and population-wide responses to drugs, 27709 Biotechnology/Life Sciences environmental toxicants, and ionizing radiation. In RTP since 2015

Credit Suisse (919) 994-5000 US Headquarters www.credit-suisse.com New York, New York 7033 Louis Stephens Drive Global Headquarters Credit Suisse is a leading global financial services company, providing businesses, P.O. Box 110047 Zurich, Switzerland institutional and high-net-worth private clients worldwide with advisory services, Research Triangle Park, NC comprehensive solutions, and excellent products. The Credit Suisse RTP Center provides 27709 Financial and Insurance Activities vital business continuity, information technology and operational support services to the In RTP since 2005 firm and their clients. 1,000 - 4,999 employees

Inspiring bold ideas™ 20 Cree, Inc. (919) 407-5300 Headquarters www.cree.com Durham, North Carolina 3028 Cornwallis Road Cree, Inc. is leading the light-emitting diode (LED) lighting revolution and setting the stage P.O. Box 12713 Clean and Green Technologies to obsolete energy-wasting traditional lighting technologies through the use of energy- Research Triangle Park, NC In RTP since 2005 efficient, environmentally friendly LED lighting. Cree develops and produces LED chips, 27709 250 - 499 employees components and lighting system products. Cree is also a developer and provider of high- C efficiency power components used to improve the energy efficiency of power supplies, renewable energy systems, motors and other systems. In addition, Cree develops industry-leading RF components used in communications and military applications.

CrossView, Inc. (919) 433-9000 Headquarters www.crossview.com/crossview/us West Palm Beach, Florida Alexander Business Suites Since 1997, CrossView has been building cross-channel solutions for clients ranging from 68 T.W. Alexander Drive Business and Professional top 10 Internet retailers down to organizations who are just expanding into more than P.O. Box 13628 Services one channel. CrossView’s premier product suite is integrated with a company’s core Research Triangle Park, NC In RTP since 2012 retail management systems to bring together all of the information around customer, 27709 Under 50 employees orders, products, pricing, promotions and inventory and make that information available to shoppers at every CrossView touchpoint in a way that delights them.

CSC Systems (919) 233-0167 Headquarters www.csc.com Falls Church, Virginia 79 T.W. Alexander Drive CSC (Computer Sciences Corporation) Systems is an IT and business services company 4201 Research Commons Information Technology that predominantly provides IT personnel staffing services in the following areas: Research Triangle Park, NC In RTP since 1978 systems integration and professional services; enterprise application development and 27709 100 - 249 employees management; application software for the financial services industry; business process outsourcing; managed hosting services; and application and IT infrastructure outsourcing.

Curasan Inc. 919-941-9770 Headquarters www.curasaninc.com Research Triangle Park, North Progress Center Carolina @curasan_inc 3200 NC Highway 54 Curasan, Inc. is the U.S. subsidiary of curasan AG Germany. curasan AG’s focus is to Cape Fear Building, Suite 201 Biotechnology/Life Sciences develop, manufacture and market unique products and services in the cutting edge P.O. Box 12339 In RTP since 2014 field of regenerative medicine. Our extensive product offerings cover the fields of bone Research Triangle Park, NC Under 50 employees and tissue regeneration, tissue engineering, and wound healing for dental, spinal and 27709 orthopaedic applications. Our flagship product, Cerasorb M, is a synthetic pure phase β-TCP. Based in the Research Triangle Park, nearby Raleigh, N.C., curasan, Inc. provides high quality competitively priced products used by Oral Surgeons, Periodontists, General Dentists, Orthopaedic Surgeons, and Neurosurgeons.

Inspiring bold ideas™ 21 CytoFlow, LLC (919) 354-1009 Headquarters www.cytoflow.com Research Triangle Park, North First Flight Venture Center Carolina CytoFlow believes it is possible to build powerful analytical tools that are accessible 2 Davis Drive and easy-to-use. They understand that researchers should be able to focus on their Research Triangle Park, NC Biotechnology/Life Sciences experiments and not have to spend weeks learning how to use and maintain the 27709 In RTP since 2014 instrument. C Under 50 employees D Danfoss Drives (717) 261-5000 US Headquarters Milwaukee, Wisconsin drives.danfoss.com 12 T.W. Alexander Drive Global Headquarters Danfoss Drives is driven by a passion to develop, manufacture and sell the best AC drives Research Triangle Park, NC Vaasa, Finland and inverters in the world, and to provide efficient life-cycle services for its customers. 27709 Their AC drives offer optimum process control and energy efficiency for electric motors. Instruments and Advanced Danfoss Drives inverters are a key component in producing energy from renewable Materials sources. In RTP since 2011 Under 50 employees

DellEMC (919) 549-8421 Headquarters Hopkinton, Massachusetts www.emc.com 62 T.W. Alexander Drive EMC is a global leader in enabling businesses and service providers to transform Research Triangle Park, NC Information Technology their operations and deliver Information Technology as a service. Fundamental to this 27709 In RTP since 1977 transformation is cloud computing. Through innovative products and services, EMC 500 - 999 employees accelerates the journey to cloud computing, helping IT departments to store, manage, protect and analyze their most valuable asset -- information -- in a more agile, trusted and cost-efficient way.

Delta Products Corporation (919) 767-3800 US Headquarters www.deltaww.com Fremont, California 5101 Davis Drive Global Headquarters Founded in 1971, Delta Products Corporation provides electronic components and P.O. Box 12173 Taipei City, Taiwan products to original equipment manufacturing/original design manufacturing (OEM/ Research Triangle Park, NC ODM) customers and distributors. Delta is a U.S. affiliate of Delta Electronics, Inc., 27709 Information Technology international electronic components and peripheral manufacturer. Delta is engaged in In RTP since 1998 the development, design, manufacture and marketing of electronics component and 50 - 99 employees equipment for OEM/ODM and distribution. Delta’s major customers include many leading companies in information, communication and consumer electroincs industries.

Inspiring bold ideas™ 22 Dharma Laboratories, LLC (919) 342-6624 Headquarters www.dharmapdlabs.com Research Triangle Park, North The Lab Carolina We have expertise in developing various dosage forms such as: oral solids, liquids, 104 T.W. Alexander Drive, injectables, and topicals etc. Dharma Labs could be a partner of choice for late stage Building 7 Pharmaceuticals and Diagnostics compounds, matured products and novel branded (Specialty) prescription pharmaceutical Research Triangle Park, NC In RTP since 2012 products. Our development programs include ANDA, Paragraph IV, NDA submissions 27709 Under 50 employees utilizing the FDA 505(b)(2) pathway that involve novel formulations and alternative delivery forms. This development approach significantly reduces development time, cost and D risk. We have decades of firsthand experience in market research, clinical development, regulatory, formulation development and technology transfer.

Dignify Therapeutics First Flight Venture Center Headquarters www.dignifytherapeutics.com 2 Davis Drive Research Triangle Park, North P.O. Box 13169 Carolina Dignify Therapeutics is a drug development company focused on developing novel Research Triangle Park, NC bladder and bowel drug therapies for spinal cord injured, multiple sclerosis and similar 27709 Pharmaceuticals and Diagnostics patient populations with voiding dysfunction. By combining novel pharmaceutical agents In RTP since 2013 with drug delivery technology, Dignify Therapeutics will restore the dignity of voluntary Under 50 employees excretory function for these patients.

DILIsym Services (919) 558-1323 Headquarters Research Triangle Park, North www.dilisymservices.com 6 Davis Drive Carolina DILIsym Services, Inc. is a startup company based in Research Triangle Park, NC P.O. Box 12137 committed to providing the pharmaceutical industry with the tools, resources and Research Triangle Park, NC Biotechnology/Life Sciences information to efficiently develop safer drug therapies that increase the availability of vital 27709 In RTP since 2015 therapeutics for the patients who need them. Under 50 employees

DOCS 79 T.W. Alexander Drive Headquarters 4401 Research Commons, Research Triangle Park, North www.docsglobal.com Suite 300 Carolina DOCS provides global strategic resourcing and FSP services to the biopharmaceutical Research Triangle Park, NC and medical device industries. Founded in 1997, DOCS has grown to become the premier 27709 Business and Professional resourcing provider for the clinical development industry. Services In RTP since 2016 Under 50 employees

Inspiring bold ideas™ 23 DTS Language Services, Inc. (800) 524-0722 Headquarters (919) 719-1406 Research Triangle Park, North www.dtstranslates.com Carolina DTS Language Services, Inc. translates documents into over 75 languages. We help The Frontier organizations in the Clinical, Biotech, Medical Device, and other Life Science markets 800 Park Offices Drive Biotechnology/Life Sciences reach international audiences quickly, accurately, and on time. 100% professional human Research Triangle Park, NC In RTP since 2017 translation (NOT software). 27709 Under 50 employees D E DuPont Electronics and Communications (919) 248-5000 Headquarters www.electronics.dupont.com Research Triangle Park, North 14 T.W. Alexander Drive Carolina The DuPont facility in the Research Triangle Park serves as the world headquarters for P.O. Box 13999 DuPont Electronics and Communications - a leading global supplier of innovative materials Research Triangle Park, NC Instruments and Advanced for the solar energy, consumer electronics, displays and advanced printing industries. 27709 Materials In RTP since 1985 100 - 249 employees

EatDrinkDeals.com (919) 812-4249 Headquarters Research Triangle Park, North www.eatdrinkdeals.com The Frontier Carolina EatDrinkDeals is the nation’s leading news website for discount dining information. 800 Park Offices Drive EatDrinkDeals covers national chains and provides restaurant coupons, coupon codes Suite 3518 Information Technology and general information on how to get the best dining deals. EatDrinkDeals was founded Research Triangle Park, NC In RTP since 2017 in 2006 and is privately owned. 27709 Under 50 employees EatDrinkDeals has been featured by Consumer Reports, Cosmopolitan, Real Simple Magazine, USA Today, and ABC-TV’s The View.

Edstar Analytics, Inc. The Frontier Headquarters www.edstaranalytics.com 800 Park Offices Drive Research Triangle Park, North 3rd Floor Carolina Our services include helping school systems, non-profits, and Institutes of Higher Research Triangle Park, NC Education to write grant proposals, evaluating grant-funded programs, setting up 27709 Information Technology infrastructure for moving into a data-driven framework, and professional develop In RTP since 2015 customized

Inspiring bold ideas™ 24 ECS Federal, Inc. (703) 270-1540 Headquarters www.ecs-federal.com Fairfax, Virginia 79 T.W. Alexander Drive Electronic Consulting Services (ECS) is a professional services firm and one of the fastest 4201 Research Commons Information Technology growing businesses in the United States. Founded by experienced information technology Research Triangle Park, NC In RTP since 2006 professionals, ECS takes pride in providing quality services and support, client-focused 27709 Under 50 employees business practices, client satisfaction, prudent cost management and reliable performance. EHR 2.0 (919) 345-2837 Headquarters E www.ehr20.com Cary, North Carolina First Flight Venture Center EHR 2.0, the new trend in healthcare IT, provides high quality training to healthcare 2 Davis Drive Business and Professional professionals to learn and meet the HIPAA compliance regulations, consulting services to P.O. Box 12076 Services secure their IT infrastructure and help prepare for federal audits. Providers of HIPAA Tool Research Triangle Park, NC In RTP since 2011 Kit and Best Practices platform. 27709 Under 50 employees

Eisai, Inc. (919) 941-6920 US Headquarters www.eisai.com Woodcliff Lake, New Jersey 900 Davis Drive Global Headquarters Eisai, Inc. is a human health-care company seeking innovative solutions in disease P.O. Box 14505 Tokyo, Japan prevention, cure and care for the health and well-being of people worldwide. Eisai, Inc Research Triangle Park, NC is owed by Eisai Company, Ltd., a Japanese pharmaceutical company that focuses on 27709 Pharmaceuticals and Diagnostics treatments for oncology, neroscience and other specialty disorders. RTP is home to Eisai’s In RTP since 1996 state-of-the-art pharmaceutical production and drug development facility for parenteral 250 - 499 employees products. In 2012 Eisai announced a Manufacturing Alliance with Biogen Idec. Biogen has assumed control of the Oral Solid Dose facility on the Eisai RTP campus and will manufacture both Eisai and Biogen OSD products in the future.

ElectroChemical Systems, Inc. (919) 354-1026 Headquarters www.fibrotools.com Research Triangle Park, North First Flight Venture Center Carolina ElectroChemical Systems, Inc. (ECSI) designs, builds and supplies efficient, precision 2 Davis Drive benchtop wet-processing equipment for electroplating and electroforming of P.O. Box 13169 Instruments and Advanced microstructures of single metals and alloys. Our equipment is delivered worldwide, Research Triangle Park, NC Materials N. America, Europe, Asia and Africa, to academic, R&D institutions and specialty 27709 In RTP since 2010 manufacturers. IKoClassic, our standard tool, has been established in numerous institutions Under 50 employees as an irreplaceable teaching and R&D tool for MEMS and NANO structure development and fabrication.

Inspiring bold ideas™ 25 Endacea, Inc. (919) 406-1888 Headquarters www.endacea.com Research Triangle Park, North First Flight Venture Center Carolina Endacea, Inc., an emerging biopharmaceutical company, is developing a series of 2 Davis Drive proprietary A1 adenosine receptor (AR) antagonists as drug candidates for a number of P.O. Box 12076 Pharmaceuticals and Diagnostics medical indications, including: 1) inflammation, including sepsis and asthma; and 2) renal Research Triangle Park, NC In RTP since 1998 impairment. Endacea is advancing the company’s lead compound A1 AR antagonist, L-97- 1, as an i.v. anti-sepsis drug candidate and as a post-exposure medical countermeasure 27709 Under 50 employees for plague and other biodefense indications. Endacea is also developing a sensitive and specific biomarker for sepsis as a companion diagnostic for Endacea’s i.v. anti-sepsis drug candidate and for other uses. E

Entegrion, Inc. 79 T.W. Alexander Drive, Headquarters www.entegrion.com 4401 Research Commons, Research Triangle Park, North Suite 200 Carolina Entegrion specializes in technologies that support and preserve the function of the human P.O. Box 14867 vascular system. Research Triangle Park, NC Pharmaceuticals and Diagnostics 27709 In RTP since 2005

EntreDot (919) 522-0722 Headquarters www.entredot.org Research Triangle Park, North The Frontier Carolina The mission of EntreDot is to help entrepreneurs create, launch and operate their 800 Park Offices Drive, businesses by providing professional mentoring and business education programs 3rd Floor Business and Professional that maximize the opportunity for success, resulting in incremental economic growth in Research Triangle Park, NC Services revenue and jobs. 27709 In RTP since 2014 Under 50 employees

ENVIGEN Pharmaceuticals (919) 314-5561 Headquarters www.envigenpharma.com Research Triangle Park, North The Lab Carolina ENVIGEN Pharmaceuticals, Inc. is a research based drug development company. The 104 T.W. Alexander Drive company is developing a number of classes of new small drug-like molecules against life Research Triangle Park, NC Pharmaceuticals and Diagnostics threatening diseases like cancer, HIV/AIDS and neurological disorders. These molecules 27709 In RTP since 2010 work in different and novel mechanistic pathways against the biomolecular targets. Under 50 employees ENVIGEN is also working with other research organizations either as a collaborator, or service provider on their drug discovery projects.

Inspiring bold ideas™ 26 Ericsson (919) 472-7000 US Headquarters www.ericsson.com Plano, Texas 4001 NC Highway 54 Global Headquarters Ericsson is the largest supplier of mobile systems in the world and supports all major P.O. Box 13905 Stockholm, Sweden standards for wireless communications. Ericsson drives the telecommunications industry Research Triangle Park, NC and provides total solutions from systems and applications to services and core 27709 Information Technology technology for mobile handsets. The world’s 10 largest mobile operators are among In RTP since 1990 Ericsson’s customers, and some 40 percent of all mobile calls are made through their 100 - 249 employees systems. Ericsson’s RTP location is focused on developing platforms for mobile terminals. E EthosExcel (919) 354-1030 Headquarters www.excelclinicalresearch.com Research Triangle Park, North First Flight Venture Center Carolina Excel Clinical Research Group is a community-engaged, US-based Contract Research 2 Davis Drive, Organization (CRO). We provide Functional Clinical Trial Resourcing, Site Management Suite 121 Pharmaceuticals and Diagnostics and Clinical Trial Operations services to biotechnology, pharmaceutical and medical Research Triangle Park, NC In RTP since 2011 device companies as well as state and federal government agencies. As part of our Site 27709 Under 50 employees Management model, we offer Principal Investigator (PI) & Trial Site Assistance services to help free investigators to focus on what they do best--take care of patients, yet also receive valuable support to enable to be successful in the conduct of clinical trials. Excel Clinical is WBENC, WOSB, NMSDC and HUB-certified.

Eton Bioscience (800) 758-1630 Headquarters www.etonbio.com San Diego, California The Lab Founded in 2003, Eton Bioscience is a privately held contract research bio-services 104 T.W. Alexander Drive, Biotechnology/Life Sciences firm headquartered in San Diego. Originally devoted to meeting the local need for DNA Building 4A In RTP since 2008 sequencing, Eton Bioscience now provides services to research institutions nationwide. In P.O. Box 110363 Under 50 employees 2008, Eton Bioscience opened its branch in The Research Triangle Park. Research Triangle Park, NC 27709

Exam Design Inc. (919) 539-8584 Information Technology www.examdesign.com In RTP since 2013 First Flight Venture Center Under 50 employees Exam Design is the leading provider of examination development software used in high- 2 Davis Drive stakes hiring decisions. The web-based suite of tools called ExamDeveloper helps users Research Triangle Park, NC to develop quality assessments for hiring and certification purposes without the time- 27709 consuming and costly in-person meetings. ExamDeveloper also supports every step in the test development process including job analysis, item banking, standard setting, and statistical analysis.

Inspiring bold ideas™ 27 Excelerate Health Ventures First Flight Venture Center Headquarters www.exceleratehealth.com 2 Davis Drive Research Triangle Park, North Suite 105 Carolina Excelerate Health Ventures is a professionally managed healthcare angel/VC fund that Research Triangle Park, NC is comprised of individuals and entities that represent healthcare providers, payers, 27709 Financial and Insurance Activities entrepreneurs, and healthcare investors. The main focus of the fund is to invest in seed In RTP since 2013 and early stage healthcare technology software/services start-ups.

Exinent The Frontier Headquarters 800 Park Offices Drive Research Triangle Park, North E www.exinent.com Research Triangle Park, NC Carolina F We have been in the Magento game longer than almost any other eCommerce shop 27709 out there, and have a passion for building world-class Magento sites, and implementing Information Technology custom extensions that take the Magento platform to the next level. In RTP since 2014 Under 50 employees

Family Health Network 919-749-0965 Headquarters www.familyhealthnetwork.com Research Triangle Park, North First Flight Venture Center Carolina Family Health Network has developed a suite of technologies that enable carers, 2 Davis Drive whether professional or non professional, to more easily participate in the care of Suite 127 Information Technology persons needing care. This technology is accessible through Family Health Network’s P.O. Box 13169 In RTP since 2009 Connected for Life membership. Features include scheduling of care calls, daily recording Research Triangle Park, NC Under 50 employees and distribution of the senior’s health status (observations of daily living or ODLs), video 27709 visits, and connections to physicians and other health care and community professionals. Connected For Life is one a few companies who place senior patients and their families at the center of a continuum of care.

Fennec Pharmaceuticals Inc. (919) 636-4530 Headquarters www.fennecpharma.com . Alexander Business Suites Research Triangle Park, North 68 T.W. Alexander Drive Carolina Fennec Pharmaceuticals Inc. is a biopharmaceutical company dedicated to the discovery P.O. Box 13628 and development of novel cancer therapeutics. Our goal is to increase the longevity and Research Triangle Park, NC Pharmaceuticals and Diagnostics improve the quality of life for many patients with cancer. We have focused our internal 27709 In RTP since 2012 efforts on Eniluracil, an oral dihydropyrimidine dehydrogenase (DPD) inhibitor, which we Under 50 employees are developing to improve the tolerability and effectiveness of 5-fluorouracil (5-FU), one of the most widely used oncology drugs in the world.

Inspiring bold ideas™ 28 Fidelity Investments (877) 236-9340 Headquarters www.fidelity.com Boston, Massachusetts 100 New Millennium Way Fidelity’s goal is to make financial expertise broadly accessible and effective in helping 7133 Louis Stephens Drive Financial and Insurance Activities people live the lives they want. With assets under administration of $5.2 trillion, including Research Triangle Park, NC In RTP since 2006 managed assets of $2.1 trillion as of November 30, 2015, Fidelity focuses on meeting the 27709 1,000 - 4,999 employees unique needs of a diverse set of customers: helping more than 24 million people invest their own life savings, nearly 20,000 businesses manage employee benefit programs, as well as providing nearly 10,000 advisory firms with technology solutions to invest their own clients’ money. Privately held for nearly 70 years, Fidelity employs 42,000 associates.

First Flight Venture Center (919) 990-8558 Headquarters F www.firstflightventure.org Research Triangle Park, North 2 Davis Drive Carolina First Flight Venture Center (FFVC) provides incubation and acceleration of new P.O. Box 13169 technologies in the Research Triangle Park (RTP) area. FFVC has been home to more than Research Triangle Park, NC Business and Professional 250 companies with a cumulative economic impact of over $800M. Tenants are provided 27709 Services business formation, product development and market commercialization programs to help In RTP since 1991 them grow and expand their businesses. At present, FFVC hosts 37 tenants involved with Under 50 employees hardware, software, medical device and life science technologies. FFVC is also a frequent host to a wide variety of community programs including CED FastTrac, Meet-Up-Groups, and life science gatherings.

FMC Corporation (919) 316-3532 Headquarters www.FMC.com Philadelphia, Pennsylvania 3040 East Cornwallis Road, FMC Corporation is a diversified chemical company serving agricultural, consumer and Johnson Building Agricultural Biosciences industrial markets globally with innovative solutions, applications and market-leading Research Triangle Park, NC In RTP since 2013 products. FMC Agricultural Solutions develops, markets and sells all three major classes 27709 Under 50 employees of crop protection chemicals: insecticides, herbicides and fungicides. These products are used in agriculture to enhance crop yield and quality by controlling a broad spectrum of insects, weeds and disease, as well as in non-agricultural markets for pest control.

Forse, Inc. 4001 NC Highway 54 Information Technology www.forseinc.com Research Triangle Park, NC In RTP since 2013 27709 Under 50 employees Forse, Inc is a circuit board repair company that specializes in diagnostics, depot repair and reverse logistics. Forse also offers warehouse and fulfillment, logistics, test development services, and custom PC/server configuration.

Inspiring bold ideas™ 29 Foundation Medicine 7010 Kit Creek Road Headquarters Research Triangle Park, NC Research Triangle Park, North www.foundationmedicine.com 27709 Carolina

Biotechnology/Life Sciences In RTP since 2016 Under 50 employees

Freudenberg IT LP (FIT) (866) 705-6395 US Headquarters www.freudenberg-it.com Research Triangle Park, North 12 T.W. Alexander Drive Carolina F Freudenberg IT (FIT) believes extraordinary things happen when the complex is made Building 100 Global Headquarters simple. Through its deep knowledge of SAP, FIT helps companies experience the value Research Triangle Park, NC Weinheim, Germany G of their enterprise application investments—without the hassle of managing complicated 27709 infrastructures on their own. From hosting to cloud computing to disaster recovery, Information Technology FIT provides the services – and security – organizations need to remain resilient in an In RTP since 2009 increasingly complex world. Customers choose FIT to improve operations, boost efficiency and reduce overall risks and costs. They stick with FIT because it does the many small 100 - 249 employees things that add up to one extraordinary thing: FIT simplifies IT.

Fujifilm Diosynth Biotechnologies (919) 337-4400 Headquarters www.fujifilmdiosynth.com Morrisville, North Carolina 6051 George Watts Hill Drive FUJIFILM Diosynth Biotechnologies is an industry leading Biologics Contract Development Research Triangle Park, NC Biotechnology/Life Sciences and Manufacturing Organization with experience in development to manufacturing of 27709 In RTP since 1995 recombinant proteins, vaccines, monoclonal antibodies and gene therapies expressed 250 - 499 employees on a wide array of microbial, mammalian, and insect cell line systems. We offer a comprehensive list of services from cell line development, including its proprietary pAVEwayTM microbial and ApolloTM mammalian expression systems to process development, analytical development, clinical and commercial manufacturing. In 2014, we expanded with a BARDA recognized site with advanced flexible facilities with expertise in viral and cell-based vaccines and capacity for higher-containment production.

G1 Therapeutics (919) 213-9835 Headquarters www.g1therapeutics.com Research Triangle Park, North 79 T.W. Alexander Drive, Carolina G1 Therapeutics is working to commercialize a proprietary small molecule-based approach 4401 Research Commons, to protect the bone marrow from damage due to chemotherapy or radiation. Damage Suite 105 Pharmaceuticals and Diagnostics to the bone marrow results in severe anemia, neutropenia, and thrombocytopenia. G1 P.O. Box 110341 In RTP since 2014 Therapeutics’ small molecules transiently arrest the cell cycle of hematopoeitic progenitor Research Triangle Park, NC Under 50 employees and stem cells in the bone marrow. 27709

Inspiring bold ideas™ 30 Galaxy Diagnostics, Inc. (919) 313-9672 Headquarters www.galaxydx.com Research Triangle Park, North Alexandria Innovation Center Carolina Galaxy Diagnostics is an early-stage infectious disease diagnostics company, specializing 7020 Kit Creek Road, in the detection of Bartonella (Cat Scratch Disease) and other difficult to diagnose zoonotic Suite 130 Pharmaceuticals and Diagnostics bacteria. Galaxy Diagnostics novel, patented growth media facilitates the detection of P.O. Box 14346 In RTP since 2009 multiple species of Bartonella leading to more accurate diagnosis and treatment of one of Research Triangle Park, NC Under 50 employees the most significant and recently discovered public health threats. 27709

GEAR UP NC (919) 237-7945 Headquarters www.northcarolina.edu Research Triangle Park, North G Alexander Business Suites Carolina GEAR UP stands for Gaining Early Awareness and Readiness for Undergraduate Programs 68 T.W. Alexander Drive and is a national college access initiative funded by the U.S. Department of Education. P.O. Box 13628 Business and Professional Research Triangle Park, NC Services 27709 In RTP since 2014

GENBAND (972) 521-5800 Headquarters www.genband.com Frisco, Texas 4001 NC Highway 54 GENBAND’s real time communications solutions help its customers connect people to Research Triangle Park, NC Information Technology each other and address the growing demands of today’s consumers and businesses for 27709 In RTP since 2010 real time communications wherever they happen to be. The company’s comprehensive 250 - 499 employees solutions suite empowers its customers to enrich their service offerings with real time contextual communications, providing a richer, more engaging user experience. GENBAND’s technology is deployable in the network, on premise or through the cloud. Our market-leading Network Modernization, Unified Communications, Mobility and Embedded Communications solutions enable our customers to quickly capitalize on growing market segments and introduce differentiating products, applications and services to their customers.

Genetron Health 6 Davis Drive Headquarters www.genetronhealth.com P.O. Box 13758 Research Triangle Park, North Research Triangle Park, NC Carolina Genetron Health is a world-leading patient oriented healthcare company specialized in 27709 cancer precision diagnostics. Genetron Health is dedicated to providing the most accurate Biotechnology/Life Sciences and timely precision diagnostics to help individuals evaluate cancer risk and to help In RTP since 2015 cancer patients by facilitating the most comprehensive personalized cancer treatment Under 50 employees options.

Inspiring bold ideas™ 31 GENEWIZ (877) 436-3949 Headquarters www.genewiz.com South Plainfield, New Jersey Alexandria Innovation Center GENEWIZ provides reliable, award-winning Sanger DNA Sequencing services to 7020 Kit Creek Road Biotechnology/Life Sciences researchers at academic, pharmaceutical, clinical, biotechnology, and government Research Triangle Park, NC In RTP since 1999 institutions. Due to a focus on excellent science and service at competitive prices, 27709 Under 50 employees GENEWIZ is the #1 trusted partner of researchers. GENEWIZ is well-equipped to handle DNA sequencing of all complexities including single tube, high-throughput, standard and solution-oriented, complex, custom, or GLP DNA sequencing projects. GENEWIZ’s mission is to eliminate bottlenecks, improve productivity, and accelerate your research progress. Gift Boogle (919) 619-2789 Headquarters G www.giftboogle.com Research Triangle Park, North First Flight Venture Center Carolina Gift Boogle is a collaborative gift-giving social network where gift givers and receivers can 2 Davis Drive connect, find inspiration and discover perfect gifts. Gift Boogle leverages the three online P.O. Box 13169 Information Technology trends of ecommerce, social media and search to transform and reinvent the gift giving Research Triangle Park, NC In RTP since 2011 process. So when Uncle Henry retires or your best friend lands the perfect job or your 27709 Under 50 employees brother’s birthday comes around, Gift Boogle is there with a notification and a selection of highly targeted and timely gift ideas that fit the person and the occasion.

Gilbarco Veeder-Root 3200 NC Highway 54 Headquarters www.gilbarco.com Catawba Building, Suite 150 Greensboro, North Carolina Research Triangle Park, NC Gilbarco, Inc. is a leading global supplier of fuel dispensing equipment and fully integrated 27709 Information Technology point of sale systems for the global petroleum marketplace. Gilbarco is headquartered in In RTP since 2007 Greensboro, NC with sales, manufacturing, research, development and service locations Under 50 employees in North and South America, Europe, Asia, the Pacific Rim and Australia.

GlaxoSmithKline (919) 483-2100 US Headquarters www.gsk.com Research Triangle Park, North 5 Moore Drive Carolina GlaxoSmithKline’s mission is to improve the quality of human life by enabling people to P.O. Box 13398 Global Headquarters do more, feel better and live longer. This mission has led GSK to a world-leading position Research Triangle Park, NC Middlesex, United Kingdom in developing new medicines, vaccines and consumer healthcare products that are used 27709 by millions of people around the world. GSK’s vision is for its value chain to be carbon Pharmaceuticals and Diagnostics neutral by 2050. GSK invests billions of dollars annually in research and development – In RTP since 1970 including researching the World Health Organization’s three priority diseases: HIV/AIDS, tuberculosis and malaria. The U.S. commercial headquarters for GSK is located in RTP, 1,000 - 4,999 employees while the corporate headquarters is in the United Kingdom.

Inspiring bold ideas™ 32 GlobalSubmit Inc. The Frontier Headquarters 800 Park Offices Dr Research Triangle Park, North www.globalsubmit.com 3rd Floor Carolina GlobalSubmit is an innovator in the field of regulated product submissions. We provide Research Triangle Park, NC technology solutions and regulatory services to support submissions to health agencies 27709 Biotechnology/Life Sciences worldwide. GlobalSubmit is dedicated to facilitating regulatory submissions between In RTP since 2015 life sciences companies and global regulatory agencies. Our flagship Submissions Under 50 employees Management Suite includes solutions for publishing, validating and reviewing eCTD submissions, as well as submission tracking and monitoring regulatory activity status. We have also introduced solutions for life sciences document management and regulatory information management.

Goldfinch Sensor Technolies and Analytics LLC (919) 480-8991 Headquarters G www.goldfinchsta.com Research Triangle Park, North First Flight Venture Center Carolina Grifols is a global healthcare company whose mission is to improve the health and 2 Davis Drive well being of people around the world. Grifols accomplishes this mission by producing Research Triangle Park, NC Service Providers life-saving protein therapies for patients and by providing hospitals, pharmacies and 27709 In RTP since 2017 healthcare professionals with the tools they need to deliver expert medical care. Under 50 employees

GoSell (800) 212-2806 Headquarters Research Triangle Park, North www.gosell.com The Frontier Carolina At its core, GoSell is a simple CRM, or PAM, Prospecting Activity Manager, where 800 Park Offices Drive prospects can be added or uploaded, noted, dispositioned, and tracked from initial call or Suite 3502 Information Technology visit to the sale. GoSell helps B2B sales people to sell, helps sales managers to manage, P.O. Box 14865 In RTP since 2017 and helps their organizations to dramatically increase revenue. Research Triangle Park, NC Under 50 employees 27709

Grifols (919) 316-6300 US Headquarters Los Angeles, California www.grifols.com 79 T.W. Alexander Drive Global Headquarters Grifols is a global healthcare company whose mission is to improve the health and 4101 Research Commons Barcelona, Spain well being of people around the world. Grifols accomplishes this mission by producing P.O. Box 110526 life-saving protein therapies for patients and by providing hospitals, pharmacies and Research Triangle Park, NC Biotechnology/Life Sciences healthcare professionals with the tools they need to deliver expert medical care. 27709 Pharmaceuticals and Diagnostics In RTP since 1999 500-999 employees

Inspiring bold ideas™ 33 GW Pharmaceuticals (919) 314-8364 Headquarters Research Triangle Park, North www.gwpharm.com NC Biotech Center Carolina GW Pharmaceuticals was founded in 1998 and is listed on both the NASDAQ Global 15 T.W. Alexander Drive Market (GWPH) and AIM, a market of the London Stock Exchange,. GW is licensed by the Research Triangle Park, NC Biotechnology/Life Sciences UK Home Office to work with a range of controlled drugs for medical research purposes. 27709 In RTP since 2015 The Group’s lead programme is the development of a product portfolio of cannabinoid Under 50 employees prescription medicines to meet patient needs in a wide range of therapeutic indications, including Sativex® Oromucosal Spray and Epidiolex® for childhood epilepsy.

Heteroz, Inc 104 T.W. Alexander Drive Headquarters G Research Triangle Park, NC Research Triangle Park, North H www.heteroz.com 27709 Carolina Heteroz, LLC. is a product and service company, located at Research Triangle Park, NC USA. The company supplies novel building blocks and screening compounds for research Instruments and Advanced & development process. We also make customer specific compounds based on their Materials molecular designs and target proteins. In RTP since 2016 Under 50 employees

Hi Fidelity Genetics First Flight Venture Center Headquarters 2 Davis Drive Research Triangle Park, North www.hifigenetics.com Research Triangle Park, NC Carolina Hi Fidelity Genetics is a start up based in Durham, NC. We develop tools to measure and 27709 predict plant traits. Such tools are essential for maintaining a sufficient supply of food as Biotechnology/Life Sciences the world’s population grows and its climate changes. In RTP since 2016 Under 50 employees

Humacyte (919) 313-9633 Headquarters www.humacyte.com Research Triangle Park, North Alexandria Innovation Center Carolina Humacyte, a privately held company, is primarily focused on developing engineered 7020 Kit Creek Road tissue products. The company uses an innovative and proprietary platform technology to P.O. Box 12695 Biotechnology/Life Sciences engineer human, extracellular matrix-based tissues that can be shaped into tubes, sheets, Research Triangle Park, NC In RTP since 2005 or particulate conformations, with properties similar to native tissues. Humacyte’s platform 27709 Under 50 employees bio-engineering technology is revolutionary in terms of both process and composition within the regenerative medicine space. The company is primarily focused on developing products for replacement of arterial and venous tissues damaged by vascular diseases.

Inspiring bold ideas™ 34 IBM Corporation 3039 East Cornwallis Road Headquarters www.ibm.com P.O. Box 12195 Armonk, New York Research Triangle Park, NC IBM Corporation strives to lead in the invention, development and manufacturing of the 27709 Information Technology industry’s most innovative technologies, including computer systems, software, storage In RTP since 1965 systems and systems technology. IBM business units with operations in RTP, include IBM 5,000+ employees Software, Global Technology Services, Systems Technology, Retail Solutions, Finance, Integrated Supply Chain, Marketing, and Human Resources.

ICON Clinical PLC (919) 294-2200 US Headquarters www.iconus.com Philadelphia, Pennsylvania 79 T.W. Alexander Drive Global Headquarters ICON Clinical PLC is a global provider of outsourced development services to the 4501 Research Commons Dublin, Ireland pharmaceutical, biotechnology and medical device industries. ICON Clinical specializes Research Triangle Park, NC in the strategic development, management and analysis of programs that support clinical 27709 Biotechnology/Life Sciences development. In RTP since 2007 50 - 99 employees I iEssence Tech Inc. The Frontier Headquarters 800 Park Offices Drive Research Triangle Park, North Third Floor Carolina Research Triangle Park, NC 27709 Under 50 employees

Impact Pharmaceutical Services, Inc. (919) 899-9248 Headquarters www.impactpharma.com Research Triangle Park, North 79 T.W. Alexander Drive Carolina Impact Pharmaceutical Services is a contract research organization that specializes in 4401 Research Commons providing medical writing, regulatory strategy and consulting, regulatory operations, and Suite 100 Pharmaceuticals and Diagnostics program management services to the pharmaceutical and biotechnology industry. P.O. Box 110423 In RTP since 2009 Research Triangle Park, NC Under 50 employees 27709

Inanovate (617) 610-1712 Headquarters www.inanovate.com Research Triangle Park, North First Flight Venture Center Carolina Inanovate’s mission is to make accurate cancer screening available and affordable to 2 Davis Drive everyone. Inanovate combines proprietary nano-scale surface technologies, protein P.O. Box 13169 Medical Devices and Instruments screening procedures and protein biomarker content with cutting-edge expertise and Research Triangle Park, NC In RTP since 2008 facilities to create advanced biochip systems for working with proteins. In addition to 27709 Under 50 employees the development of clinical diagnostic systems, Inanovate offers pre-clinical products and services that make protein biochip based research more accurate, reliable and cost effective.

Inspiring bold ideas™ 35 Indexus Biomedical LLC (919) 824-0419 Headquarters Research Triangle Park, North Indexus Biomedical LLC is engaged in the design, development, and manufacturing of First Flight Venture Center Carolina multifunction instrument systems, reagents and assays for hematology and immunoassay 2 Davis Drive diagnostic applications. The company’s mission is to make advanced diagnostic testing affordable and accessible to all. The first product under development is a portable bench Research Triangle Park, NC Medical Devices and Instruments top system that performs the Complete Blood Count (CBC) with WBC Differential, HIV 27709 In RTP since 2013 diagnosis, the CD4 count, tests for malaria, dengue fever, Hepatitis A, Hepatitis B, and Under 50 employees tests for cardiac and kidney biomarkers. Indexus Biomedical is currently funded by NIH/ NIAID (SBIR), matching fund from NC Sate Dept Commerce, and private funds.

Inivata Inc 7020 Kit Creek Road Headquarters Suite 140 Research Triangle Park, North www.inivata.com Research Triangle Park, NC Carolina A revolution in precision cancer genomics - Liquid biopsies to clinical outcomes - Inivata is 27709 a global clinical cancer genomics company. Biotechnology/Life Sciences In RTP since 2016 I Under 50 employees

Intarcia Therapeutics, Inc 6 Davis Drive Headquarters www.intarcia.com Research Triangle Park, NC Boston, MA 27709 Intarcia Therapeutics, Inc., is a rapidly emerging biopharmaceutical company committed Biotechnology/Life Sciences to developing innovative therapies that merge medicine with technology, and have the In RTP since 2015 potential to transform therapeutic categories. We focus our efforts on serious diseases Under 50 employees that are prevalent and poorly controlled. Our near-term goal is to deliver a game-changing new level of freedom for a vast number of patients with type 2 diabetes. Making a real difference in this disease is our future and our passion.

Integrated Technical Services Research Commons Headquarters www.itsco.com 79 T.W. Alexander Drive Research Triangle Park, North Research Triangle Park, NC Carolina At Integrated Technical Services, we integrate the best network and system engineering 27709 talent to provide comprehensive and balanced IT services and solutions that deliver real Information Technology value to your business. From Healthcare and Telecom to Manufacturing and Education, we In RTP since 2015 have worked closely and successfully with hundreds of customers to help navigate the Under 50 employees ever-changing IT landscape and to deliver positive, demonstrable results.

Inspiring bold ideas™ 36 Integrated Training Solutions, Inc. (919) 353-1870 Headquarters www.itsnc.net Sanford, North Carolina First Flight Venture Center Founded in 1999, ITS designs, develops, operates, and maintains advanced simulation 2 Davis Drive Information Technology based decision support capabilities to reduce cost and increase efficiency for the rapid P.O. Box 13169 In RTP since 2011 analysis, assessment and execution of critical issues. These capabilities usebest practices Research Triangle Park, NC Under 50 employees that include cost-effective, structured, repeatable, and on-line capabilities and methods. 27709 The simulation quickly and efficiently delivers data-based assessments at significantly less cost than traditional methods. The capabilities are derived from patent pending software for domains that include: front-end analysis, assessments, requirements determination, gap analysis, strategic planning, training analysis, implementation planning, program management, acquisition planning, facilitation services, budget planning and execution, source selection and portfolio management.

Intelligaia (715) 699-5301 Headquarters www.intelligaia.com Research Triangle Park, North The Frontier Carolina I @Intelligaia 800 Park Offices Drive At Intelligaia we follow a user centric design process where the users’ needs and Suite 406 Information Technology experiences are placed at the center, providing UI and UX consulting services for Research Triangle Park, NC In RTP since 2015 enterprise customers. The experience is defined and designed around the user by 27709 Under 50 employees creating customer journey maps and stories. We then work with technology and partners transform these customer stories to products.

International Services Assistance Fund (919) 990-9099 Headquarters www.isafonline.org Research Triangle Park, North The Frontier Carolina The mission of International Services Assistance Fund (ISAF) is to encourage women’s 800 Park Offices Drive reproductive health, rights and empowerment. ISAF works to fulfill this mission through 3rd Floor Foundations, Institutes and research and education, particularly by facilitating the use of safe, inexpensive and non- P.O. Box 13067 Scientific Associations coercive family planning methods, specifically the quinacrine pellet method of nonsurgical Research Triangle Park, NC In RTP since 2005 permanent female contraception. 27709 Under 50 employees

International Society of Automation (919) 549-8411 Headquarters www.isa.org Research Triangle Park, North 67 T.W. Alexander Drive Carolina Founded in 1945, the International Society of Automation is a leading, global, nonprofit P.O. Box 12277 organization that is setting the standard for automation by helping over 40,000 worldwide Research Triangle Park, NC Foundations, Institutes and members and other professionals solve difficult technical problems, while enhancing 27709 Scientific Associations their leadership and personal career capabilities. Based in Research Triangle Park, North In RTP since 1980 Carolina, ISA develops standards; certifies industry professionals; provides education and 50 - 99 employees training; publishes books and technical articles; and hosts conferences and exhibitions for automation professionals. ISA is the founding sponsor of the Automation Federation.

Inspiring bold ideas™ 37 International Union of Pure & Applied Chemistry (IUPAC) (919) 485-8700 Headquarters www.iupac.org Research Triangle Park, North 79 T.W. Alexander Drive Carolina IUPAC is a voluntary, non-governmental, nonprofit organization that unites chemists 4201 Research Commons worldwide to apply chemistry for the benefit of humankind and for the solution of world P.O. Box 13757 Foundations, Institutes and problems of sustainable development. Research Triangle Park, NC Scientific Associations 27709 In RTP since 1997 Under 50 employees i-xploremyhealth First Flight Venture Center Headquarters www.i-xploremyhealth.com 2 Davis Drive Boston, Massachusetts Research Triangle Park, NC Patient education is a significant part of preventive healthcare. i-xploremyhealth helps 27709 Pharmaceuticals and Diagnostics patients recognize early symptoms and understand the diagnosis given by their doctors. In RTP since 2014 In this way, they are able to participate actively in the care of their own health. I JMC (USA), Inc. (919) 549-4150 US Headquarters www.jmcusa.com One Innovation Drive Austin, Texas J P.O. Box 12138 Global Headquarters JMC (USA), Inc. is a wholly owned subsidiary of Japan Metals and Chemicals Company, Research Triangle Park, NC Tokyo, Japan K Ltd. The Chromium Division, located in RTP, produces high-purity chromium metal that 27709 is the highest purity commercially produced chromium metal available in the world. The Instruments and Advanced primary use of the material is in the production of active matrix flat panel displays. Materials In RTP since 1992 Under 50 employees

Jobacuda LLC (919) 710-2978 Headquarters Research Triangle Park, North www.jobacuda.com The Frontier Carolina We design and sell Jobacuda, a cloud-based solution that helps contractors run their 800 Park Offices Drive businesses and get paid faster. Suite 3406 Information Technology Research Triangle Park, NC In RTP since 2015 27709 Under 50 employees

Kate Pope Photography (919) 818-9536 Headquarters Research Triangle Park, North www.KatePope.com The Frontier Carolina Professional portrait and wedding photography. Kate Pope Photography aims to create 800 Park Offices Drive beautiful and timeless photos that you will love just as much today as you do years from Suite 3609 Business and Professional now, whether it’s for your family, your business or your wedding. KPP regularly works in Research Triangle Park, NC Services and around North Carolina, but is available for travel to new and exciting destinations, too. 27709 In RTP since 2017 Under 50 employees

Inspiring bold ideas™ 38 KBI Biopharma 2 Triangle Drive Headquarters www.kbibiopharma.com Research Triangle Park, NC Research Triangle Park, North 27709 Carolina KBI Biopharma, Inc. (KBI) is a leading development and contract manufacturing organization serving the biopharmaceutical industry. We help our client partners accelerate and Pharmaceuticals and Diagnostics optimize drug development and manufacturing programs by offering an extensive suite In RTP since 2013 of expert development and manufacturing services in an agile, client-friendly partnering Under 50 employees environment. Clients include global pharmaceutical and biotechnology companies and academic/nonprofit organizations. Today we serve more than 150 customers in the US, Canada, Europe, Korea and Japan, including most of the top ten pharmaceutical companies.

Koolbridge Solar Inc. First Flight Venture Center Headquarters wwww.koolbridgesolar.com 2 Davis Drive Wrightsville Beach, North Carolina Research Triangle Park, NC Koolbridge Solar is a young company with patented and patent-pending prototyped 27709 Clean and Green Technologies products under development for residential, commercial, and solar farms. Our patented In RTP since 2015 “Smart Load Center” is a breaker panel box where each circuit breaker decides Under 50 employees independently whether to use the electric grid or the solar grid in order to maximize cost savings to the consumer. K Lenovo 7001 Development Drive Headquarters L www.lenovo.com Research Triangle Park, NC Research Triangle Park, North 27709 Carolina Lenovo is innovating to lead in the PC+Era. Already the worlds leading PC Company, Lenovo is also a leader in smartphones, tablets and enterprise servers. Lenovo has Information Technology quickly become one of the most respected technology companies in the world. In RTP since 2014 1,000 - 4,999 employees

LifeNet Health 6 Davis Drive Headquarters Research Triangle Park, NC Research Triangle Park, North www.lifenethealth.org 27709 Carolina For over 30 years, LifeNet Health has been the world’s most trusted provider of transplant solutions, from organ procurement to new innovations in bio-implant technologies and Biotechnology/Life Sciences cellular therapies—a leader in the field of regenerative medicine, while always honoring the In RTP since 2016 donors and healthcare professionals that allow the healing process. Under 50 employees

Inspiring bold ideas™ 39 Linde (919) 549-0633 US Headquarters www.linde.com Murray Hill, New Jersey 11 Triangle Drive Global Headquarters Linde develops state-of-the-art low particle gases and associated blending techniques in P.O. Box 12388 Munich, Germany support of semiconductor development and fabrication. The facility also is a liquid and gas Research Triangle Park, NC helium supplier to the medical industry. The entire facility is ISO 9001:2008 registered. 27709 Instruments and Advanced Materials In RTP since 1977 50 - 99 employees

Live Gamer (919) 433-1460 Headquarters www.livegamer.com New York, New York Alexander Business Suites Live Gamer’s patent-pending method uses the Internet to deliver targeted advertising to 68 T.W. Alexander Drive Business and Professional consumers in a way that breaks through the clutter like never before, and helps marketers Research Triangle Park, NC Services and audiences interact in new and meaningful ways. 27709 In RTP since 2000

Lucideon (919) 504-4900 Headquarters Research Triangle Park, North www.lucideon.com 79 T.W. Alexander Drive Carolina Lucideon is an international, independent materials technology company that applies 4401 Research Commons L its materials expertise in ceramics, metals and polymers to a range of sectors including Suite 101 Instruments and Advanced healthcare, construction, ceramics, aerospace, nuclear and power generation. Research Triangle Park, NC Materials M 27709 In RTP since 2015 Under 50 employees

Luzverde Partners (561) 510-0804 Headquarters Research Triangle Park, North www.luzverde.com The Frontier Carolina Luzverde Partners is a global partnership of creatives and technologists dedicated to your 800 Park Offices Drive ideal. We are an in-house creative agency that works with a select group of clients who Suite 3617 Business and Professional we consider to be partners. Our services include digital and print marketing, customer Research Triangle Park, NC Services relationship management, website development, and being an all around go-getter. Our 27709 In RTP since 2017 mission is to create maximum abundance for our clients. Under 50 employees

Market Technologies Inc. Alexander Business Suites Headquarters www.mktec.com 68 T.W. Alexander Drive Charlevoix, Michigan Research Triangle Park, NC Technology company with offerings mainly in the retail and consumer product industry. 27709 Information Technology MTI offers mobile and web solutions for consumer product companies, consumers and In RTP since 2014 retailers. In addition, our products group offers engineering and logistic services for the Under 50 employees same industry profile.

Inspiring bold ideas™ 40 Maverick Synfuels (919) 749-8717 Headquarters www.mavericksynfuels.com Research Triangle Park, North The Lab Carolina Maverick Synfuels is a second-generation chemicals and fuels company using proven 104 T.W. Alexander Drive technologies to convert low-value and renewable feedstocks - such as methane Building 4A Clean and Green Technologies (natural gas, landfill gas, anaerobic digester gas) or solid feedstocks such as biomass, P.O. Box 13108 In RTP since 2011 municipal solid waste (MSW)- into high-value, petroleum-replacing chemicals and fuels. Research Triangle Park, NC Under 50 employees By producing petroleum-replacing chemicals and fuels, Maverick can help reduce our 27709 nation’s dependence on foreign oil, reduce greenhouse gas emissions, and stimulate local economies.

MCNC (919) 248-1900 Headquarters www.mcnc.org Research Triangle Park, North 3021 East Cornwallis Road Carolina MCNC, a technology nonprofit that builds, owns and operates the North Carolina P.O. Box 12889 Research and Education Network (NCREN) has served research, education, nonprofit Research Triangle Park, NC Information Technology health care and other community institutions in the state for more than 30 years. NCREN 27709 In RTP since 1980 currently serves as the fundamental broadband infrastructure for more than 500 of these 50 - 99 employees institutions including all NC K-20 public education. NCREN, one of the nation’s premier middle-mile backbone networks, allows MCNC to customize services and applications, further enabling private-sector providers to leverage high-speed fiber to bring cost- efficient connectivity to rural and underserved areas of North Carolina. Our business and partnering strategy gives the state a competitive advantage and is driving the interconnected economy in North Carolina. M Medicago (919) 313-9670 US Headquarters www.medicago.com Research Triangle Park, North 7 Triangle Drive Carolina Medicago is a clinical-stage biotechnology company focused on developing highly P.O. Box 14545 Global Headquarters effective and competitive vaccines based on proprietary manufacturing technologies Research Triangle Park, NC Quebec, Canada and Virus-Like Particles (VLPs). Medicago’s VLP manufacturing technology is based on 27709 a transient expression system which produces recombinant vaccine antigens in non- Agricultural Biosciences transgenic plants. This technology has the potential to offer speed and cost advantages In RTP since 2010 over competitive technologies.

Memscap, Inc. (919) 248-4102 Headquarters www.memscapinc.com Research Triangle Park, North 3021 East Cornwallis Road Carolina MEMSCAP manufactures innovative products and solutions based on micro- P.O. Box 14486 electromechanical systems (MEMS) to address customer needs in micro and Research Triangle Park, NC Instruments and Advanced nanotechnology applications for telecommunications, biomedical, and sensing markets. 27709 Materials

Inspiring bold ideas™ 41 MethodSense, Inc. (919) 313-3962 Headquarters www.methodsense.com Research Triangle Park, North 3200 NC Highway 54 Carolina MethodSense is a life science consulting firm with offices in the US and Europe. We Cape Fear Building, Suite 101 guide medical device, biotech and pharmaceutical companies with quality, regulatory and P.O. Box 110352 Medical Devices and Instruments technology solutions. Our services enable clients to operate more effectively during the Research Triangle Park, NC In RTP since 2010 commercialization process and beyond. MethodSense also develops InfoStrength Smart 27709 Under 50 employees Enterprise Suite (SES), an enterprise document and business management software. InfoStrength SES is a Software as a Service (SaaS) application designed specifically for regulated businesses. MethodSense’s mission: the development and implementation of FDA compliant commercialization processes that meet business needs for enhanced efficiency and profitability.

Microelectronics Assembly Technologies (919) 314-5520 Headquarters www.microassemblytech.com Research Triangle Park, North The Lab Carolina The mission of Microelectronics Assembly Technologies (MAT) is to successfully 104 T.W. Alexander Drive commercialize its new broad based multi-chip memory module technology for high- Building 7, Room 727 Information Technology density blade server computers and mobile computing applications. Additionally, P.O. Box 13279 In RTP since 2006 MAT offers flip chip assembly services in a clean room environment for medical and Research Triangle Park, NC Under 50 employees astomonical imaging detectors (X-ray, Gamma-ray) and MEMS devices. 27709

Micross Components 3021 E Cornwallis Road Headquarters Research Triangle Park, NC Research Triangle Park, North M www.micross.com 27709 Carolina Professional portrait and wedding photography. Kate Pope Photography aims to create beautiful and timeless photos that you will love just as much today as you do years from Instruments and Advanced now, whether it’s for your family, your business or your wedding. KPP regularly works in Materials and around North Carolina, but is available for travel to new and exciting destinations, too. In RTP since 2016 Under 50 employees

Mispro Biotech Services 6 Davis Drive Headquarters Research Triangle Park, NC Research Triangle Park, North www.misprobiotech.com 27709 Carolina Since 2003, Mispro Biotech Services has provided complete animal husbandry and a wide range of technical and support services to meet the pre-clinical and in-vivo needs of Biotechnology/Life Sciences the biomedical and pharmaceutical industries. Our secure, state-of-the-art facilities offer In RTP since 2016 everything from static and ventilated cages, to in-room Class II biological safety cabinets, to Under 50 employees procedure rooms.

Inspiring bold ideas™ 42 Mokobio Biotechnology R&D Center The Lab US Headquarters www.mokobio.com.cn 104 T.W. Alexander Drive Research Triangle Park, North Building 7 Carolina Research and development of diagnostic kits on infectious diseases. Research Triangle Park, NC Global Headquarters 27709 Beijing, China

Biotechnology/Life Sciences In RTP since 2014 Under 50 employees

Monsanto Corporation 110 T.W. Alexander Drive Headquarters www.monsanto.com Research Triangle Park, NC St. Louis, Missouri 27709 Monsanto Corporation is an agricultural company that applies innovation and technology Agricultural Biosciences to help farmers around the world produce more while conserving more. Producing more, In RTP since 2005 conserving more, improving lives. That’s sustainable agriculture and that’s what Monsanto 50 - 99 employees is all about. Billions of people depend on what farmers do. And so will billions more. In the next few decades, farmers will have to grow as much food as they have in the past 10,000 years-combined. It is Monsanto’s purpose to work alongside farmers to do exactly that. Monsanto does this by selling seeds, traits developed through biotechnology, and crop protection chemicals.

Motor & Equipment Manufacturers Association (MEMA) (919) 459-4800 Headquarters M www.mema.org Research Triangle Park, North 10 Laboratory Drive Carolina MEMA supports its members through its four affiliate associations, Automotive P.O. Box 13966 Aftermarket Suppliers Association (AASA), Heavy Duty Manufacturers Association Research Triangle Park, NC Business and Professional (HDMA), Motor & Equipment Remanufacturers Association (MERA) and Original Equipment 27709 Services SuppliersAssociation (OESA). MEMA represents more than 1000 member companies In RTP since 1992 with global motor vehicle parts sales exceeding $600 billion. The motor vehicle parts Under 50 employees manufacturers are the largest employer of manufacturing jobs in the U. S. with over 700,000 direct workers.

Murano Corporation (919) 314-2896 Headquarters www.muranocorp.com Research Triangle Park, North Alexander Business Suites Carolina Murano Corporation’s mission is to help organizations build resilient, integrated, 68 T.W. Alexander Drive streamlined, and efficient (RISE) supply chains using our Cloud Supply Chain Manager Suite 207 Information Technology technology. Cloud Supply Chain Manager is an Enterprise Resource Planning (ERP) for Research Triangle Park, NC In RTP since 2015 small and medium sized businesses and a Supply Chain Resource Planning (SCRP) for 27709 Under 50 employees Fortune 1000 enterprises.

Inspiring bold ideas™ 43 myDrugCosts, Inc. (919) 335-3784 Headquarters www.mydrugcosts.com Research Triangle Park, North First Flight Venture Center Carolina myDrugCosts, Inc. operates a software-as-a-service (SaaS) platform for health systems and 2 Davis Drive, other large employers that provides relevant, cost-saving information about prescription Suite 502 Information Technology drugs. In an industry with an estimated $91 billion of annual waste on prescription drug P.O. Box 13169 In RTP since 2011 spending due to suboptimal consumer choices, myDrugCosts mobile and web solutions Research Triangle Park, NC Under 50 employees empower employees to make more effective health care purchasing decisions and to 27709 lower prescription drug costs for themselves and their employers.

National Computing Center (919) 541-0324 Headquarters www.epa.gov/oaintrnt/facilities/rtp_ncc.htm Research Triangle Park, North 109 T.W. Alexander Drive Carolina EPA’s NCC, one of the largest computer centers in the United States, provides large-scale Research Triangle Park, NC computing services for EPA nationwide. NCC also supports regulatory program offices and 27709 Information Technology administrative activities, as well as advanced supercomputing for scientific research in air Under 50 employees quality protection and other environmental studies.

National Humanities Center (919) 549-0661 Headquarters www.nationalhumanitiescenter.org Research Triangle Park, North 7 T.W. Alexander Drive Carolina The National Humanities Center is the leading independent American institute for P.O. Box 12256 advanced study in all fields of the humanities that seeks to ensure the continuing strength Research Triangle Park, NC Foundations, Institutes and of the liberal arts and to affirm the importance of the humanities in American life. 27709 Scientific Associations M In RTP since 1978 N Under 50 employees

National Inclusion Project (919) 314-5540 Headquarters www.inclusionproject.org Research Triangle Park, North The Frontier Carolina The National Inclusion Project opens doors for all children to be included together and 800 Park Offices Drive experience all that life has to offer. The National Inclusion Project conducts programs 3rd Floor Foundations, Institutes and with community partners to teach others how to be inclusive so that kids with and without P.O. Box 110104 Scientific Associations disabilities can experience life long benefits. The National Inclusion Project believes no Research Triangle Park, NC In RTP since 2008 child should sit on the sidelines. 27709 Under 50 employees

Inspiring bold ideas™ 44 National Institute of Environmental Health Sciences (919) 541-3345 Headquarters Research Triangle Park, North (NIEHS) 111 T.W. Alexander Drive Carolina www.niehs.nih.gov P.O. Box 12233 The National Institute of Environmental Health Sciences (NIEHS), located in Research Research Triangle Park, NC Foundations, Institutes and Triangle Park, North Carolina, is one of 27 research institutes and centers that comprise 27709 Scientific Associations the National Institutes of Health (NIH) (http://www.nih.gov/), U.S. Department of Health and In RTP since 1966 Human Services (DHHS) (http://www.dhhs.gov/). The mission of the NIEHS is to discover 1,000 - 4,999 employees how the environment affects people in order to promote healthier lives.

National Institute of Statistical Sciences (NISS) (919) 685-9300 Headquarters www.niss.org Research Triangle Park, North 19 T.W. Alexander Drive Carolina The National Institute of Statistical Sciences (NISS) conducts and catalyzes collaborative P.O. Box 14006 research in statistical studies. Principal activities are research projects in areas such as Research Triangle Park, NC Foundations, Institutes and bioinformatics, data confidentiality, data integration, data quality, education statistics, 27709 Scientific Associations healthcare, transportation, and complex surveys. A multi-sector (industry, government In RTP since 1990 and academia) Affiliates Program plays vital research stimulation, dissemination, human Under 50 employees resources and networking functions. Together with Duke, North Carolina State University and the University of North Carolina at Chapel Hill, NISS operates the Statistical and Applied Mathematical Sciences Institute (SAMSI), which is co-located with NISS.

National Toxicology Program (919) 541-0255 Headquarters ntp.niehs.nih.gov Research Triangle Park, North 111 T.W. Alexander Drive Carolina N Headquartered at the National Institute of Environmental Health Sciences (NIEHS), the P.O. Box 12233 National Toxicology Program (NTP) was established to meet the need for a program to Research Triangle Park, NC Biotechnology/Life Sciences address scientific, regulatory and Congressional concerns about the human health effects 27709 In RTP since 1978 of chemical agents in our environment. The NTP coordinates toxicology testing programs; Under 50 employees strengthens the toxicology science base; develops and validates testing methods; and provides information on potentially toxic chemicals and their harms.

NC Biotechnology Center (919) 541-9366 Headquarters www.ncbiotech.org Research Triangle Park, North 15 T.W. Alexander Drive Carolina The North Carolina Biotechnology Center makes the connections that create biotech jobs P.O. Box 13547 for North Carolina. Established in 1984 by the state, the NC Biotechnology Center is a Research Triangle Park, NC Biotechnology/Life Sciences private, nonprofit corporation supported by the General Assembly. NC Biotech programs 27709 In RTP since 1984 and statewide offices create jobs for North Carolina through support of biotechnology 50 - 99 employees research, business and education and strategic policy statewide. Visit ncbiotech.org for more information about funding, events, resources and connectionsto help your life- science business succeed.

Inspiring bold ideas™ 45 NC Families Accessing Services Through Technology 79 T.W. Alexander Drive, Information Technology 4301 Research Commons In RTP since 2014 (NC FAST) Research Triangle Park, NC 100 - 249 employees www.ncdhhs.gov/ncfast 27709 The NC FAST Program is designed to improve the way NC DHHS and the 100 county departments of social services conduct business. NC FAST introduces new technological tools and business processes that will enable staff to spend less time performing administrative tasks and more time assisting families.

NC GlaxoSmithKline Foundation (919) 483-2140 Headquarters www.ncgskfoundation.org Research Triangle Park, North 5 Moore Drive Carolina The North Carolina GlaxoSmithKline Foundation supports activities in North Carolina that P.O. Box 13398 help to meet the educational and health needs of today’s society and future generations. Research Triangle Park, NC Foundations, Institutes and The Foundation focuses on programs that emphasize the understanding and application 27709 Scientific Associations of health, science and education at all academic and professional levels. In RTP since 1986 Under 50 employees

NC Healthcare Information and (919) 558-9258 Headquarters Research Triangle Park, North Communications Alliance (NCHICA) 3200 NC Highway 54 Carolina www.nchica.org Cape Fear Building, Suite The North Carolina Healthcare Information and Communications Alliance, Inc. (NCHICA) 200 Information Technology is a 501(c)(3) nonprofit consortium dedicated to assisting its members in accelerating the P.O. Box 13048 In RTP since 1994 transformation of the U.S. healthcare system through the effective use of information Research Triangle Park, NC Under 50 employees N technology, informatics and analytics. Our nearly 300 member organizations represent 27709 the many sectors of the healthcare industry: hospitals and health systems, professional societies and nonprofit associations, state and local health agencies, health plans, law firms, health IT consulting firms and vendors, health education and training providers, and research organizations.

NC New Schools 919-277-3760 Headquarters www.ncnewschools.org Research Triangle Park, North 79 T.W. Alexander Drive Carolina NC New Schools/Breakthrough Learning is one of the largest public school innovation 4501 Research Commons agencies in the country. We are a professional services agency focused on developing Suite 300 Business and Professional high-performing schools and districts. Research Triangle Park, NC Services 27709 In RTP since 2015 Under 50 employees

Inspiring bold ideas™ 46 NC State Education Assistance Authority (919) 549-8614 Headquarters www.ncseaa.edu Research Triangle Park, North 10 T.W. Alexander Drive Carolina The North Carolina State Education Assistance Authority (SEAA) is an agency of the State P.O. Box 14103 of North Carolina that promotes access to higher education by administering financial aid Research Triangle Park, NC Foundations, Institutes and and savings programs, informing students and families about paying for college, teaching 27709 Scientific Associations educators about financial aid administration, and advocating for resources to support In RTP since 1978 students. 50 - 99 employees

NC State University MBA@RTP (919) 515-5584 Headquarters www.mgt.ncsu.edu/mba Raleigh, North Carolina One Park Drive The North Carolina State University MBA@RTP part-time program location, conveniently Research Triangle Park, NC Business and Professional located in The Research Triangle Park, makes it more convenient for working 27709 Services professionals to advance their careers. The program is designed specifically for In RTP since 2007 Triangle-area professionals who want to earn their NC State MBA as part-time students. Under 50 employees Technology-focused concentrations designed to help students bring value to their company, and their professional portfolio.

NC State - UNC Joint Department of Biomedical Engineering The Frontier Headquarters 800 Park Offices Drive Research Triangle Park, North www.bme.ncsu.edu Research Triangle Park, NC Carolina The mission of the Joint Department of Biomedical Engineering is to unite engineering 27709 and medicine to improve lives. With 35 primary teaching and research faculty members Education and more than 500 undergraduate, Master’s, and doctoral students, the Joint Department In RTP since 2016 N is on track to realize its ambitious vision of becoming a leader in real-world results: faculty Under 50 employees productivity, student accomplishment, and entrepreneurial success.

NephroGenex Inc. (609) 986-1780 Headquarters www.nephrogenex.com Princeton, New Jersey 79 T.W. Alexander Drive, NephroGenex is a drug development company focusing on kidney disease. The 4401 Research Commons Pharmaceuticals and Diagnostics company is developing Pyridorin (pyridoxamine dihydrochloride) as a treatment to slow Suite 290 In RTP since 2011 the progression of diabetic kidney disease. Pyridorin is one of only a few drug candidates P.O. Box 14188 Under 50 employees in advanced clinical trials for diabetic kidney disease and possesses a distinctly new Research Triangle Park, NC mechanism of action which targets an important diabetes-induced underlying cause of the 27709 disease.

NetApp, Inc. (919) 476-5600 Headquarters www.netapp.com Sunnyvale, California 7301 Kit Creek Road Leading organizations worldwide count on NetApp for software, systems and services to P.O. Box 13917 Information Technology manage and store their data. Customers value our teamwork, expertise and passion for Research Triangle Park, NC In RTP since 2004 helping them succeed now and into the future. 27709 1,000 - 4,999 employees

Inspiring bold ideas™ 47 Network Development Group (919) 990-9070 Headquarters www.netdevgroup.com Research Triangle Park, North First Flight Venture Center Carolina Network Development Group (NDG) provides telecommunications network support 2 Davis Drive software and e-learning tools, as well as information technology infrastructure design P.O. Box 13006 Information Technology and consulting services. NDG’s NET-LAB product is the premier remote lab appliance Research Triangle Park, NC In RTP since 1999 for information technology training and distance learning. NET-LAB provides a unique 27709 Under 50 employees e-learning experience for networking students and training.

NeuroRepair Therapeutics, Inc 79 T.W. Alexander Drive Headquarters www.neurorepairx.com 4401 Research Commons Research Triangle Park, North Research Triangle Park, NC Carolina NeuroRepair, Inc. owns two issued patents and other pending patent applications, 27709 respecting methods of treatments of central nervous system disorders and injuries, Biotechnology/Life Sciences including stroke, Alzheimer’s disease, Parkinson disease, spinal cord injury, retinal In RTP since 2015 disorders, and brain injury from head trauma. Under 50 employees

New River Investments (919) 667-6147 Headquarters Los Angeles, California www.newriverinvestments.com The Frontier Registered investment advisor providing various fixed income and equity separate 800 Park Offices Drive Financial Services and account investment strategies to individuals, corporations, non-profits, and other Suite 3707 Technologies institutions. Research Triangle Park, NC In RTP since 2017 27709 Under 50 employees N NIRvana Sciences, Inc. First Flight Venture Center Headquarters www.nirvanasciences.com 2 Davis Drive Research Triangle Park, North Research Triangle Park, NC Carolina NIRvana Sciences develops and commercializes near-infrared fluorescence dyes for use 27709 in medical diagnostics and optical imaging. Pharmaceuticals and Diagnostics In RTP since 2013 Under 50 employees

Novartis Vaccines 7030 Kit Creek Road US Headquarters www.novartis.com Research Triangle Park, NC Cambridge, Massachusetts 27709 Global Headquarters The Novartis Vaccines division is a leader in providing products to fight more than 20 Basel, Switzerland vaccine-preventable viral and bacterial diseases. The only thing better than finding a cure for a disease is preventing illness in the first place. Novartis Vaccines - the world’s fifth Pharmaceuticals and Diagnostics largest manufacturer of vaccines and the second largest producer of influenza vaccine In RTP since 2013 - is committed to the fulfillment of this highest of medical ideals. By our very function, we Under 50 employees play a key role in the Novartis core mission: keeping healthy people healthy by alleviating suffering and enhancing quality of life. At Novartis Vaccines, caring begins with prevention.

Inspiring bold ideas™ 48 NovaTarg, Inc. (919) 406-4367 Headquarters www.novatargtherapeutics.com Research Triangle Park, North First Flight Venture Center Carolina NovaTarg is a research and development company founded by Dr. Ken Batchelor in 2009 2 Davis Drive for the purpose of discovering innovative medicines to treat metabolic diseases and P.O. Box 13169 Pharmaceuticals and Diagnostics cancer. NovaTarg’s primary focus is activation of AMPK, a key regulator of energyutilization Research Triangle Park, NC In RTP since 2009 in cells. Advanced leads have been identified and are being evaluated for drug candidate 27709 Under 50 employees properties. NovaTarg’s first drug candidate will be for the treatment of hepatocellular carcinoma.

NOVO, LLC The Frontier Headquarters 800 Park Offices Drive Research Triangle Park, North 3rd Floor Carolina Research Triangle Park, NC 27709 Biotechnology/Life Sciences In RTP since 2016 Under 50 employees

Novocor Medical Systems First Flight Venture Center Headquarters www.novocormed.com 2 Davis Drive Research Triangle Park, North Research Triangle Park, NC Carolina Novocor Medical Systems provides solutions that help Emergency Medical Service first 27709 responders save lives. Our patented product, HypoCore, is an innovative rapid chilling Biotechnology/Life Sciences device that cools saline during the infusion process to induce therapeutic hypothermia. In RTP since 2015 HypoCore is ready on demand, attaches in-line to standard IV tubing and instantly cools Under 50 employees N saline for up to 30 minutes without any external power. It is easily stored in ambulances, fire trucks, and helicopters and can be carried anywhere EMS personnel go.

Novozymes 108 T.W. Alexander Drive, US Headquarters www.novozymes.com Suite 1A Franklinton, North Carolina Research Triangle Park, NC Global Headquarters Novozymes is the world leader in bioinnovation. Together with customers across a broad 27709 Bagsvaerd, Denmark array of industries we create tomorrow’s industrial biosolutions, improving our customers’ business and the use of our planet’s resources. With over 700 products used in 130 Agricultural Biosciences countries, Novozymes’ bioinnovations improve industrial performance and safeguard the In RTP since 2014 world’s resources by offering superior and sustainable solutions for tomorrow’s ever- 50 - 99 employees changing marketplace.

Inspiring bold ideas™ 49 Novus Energy Technologies, Inc. The Lab Headquarters www.novusenergytechnologies.com 104 T.W. Alexander Drive Research Triangle Park, North Building 4 Carolina Leveraging breakthroughs in materials and device design, Novus’ high efficiency Research Triangle Park, NC thermoelectric systems provide heat to electric conversion or heat-pumping for significant 27709 Clean and Green Technologies energy savings in small and large scale applications. In RTP since 2016 Under 50 employees

NPBiosciences 6 Davis Drive Headquarters www.npbiosciences.com Research Triangle Park, NC Research Triangle Park, North 27709 Carolina NPBiosciences is a cutting edge biotech company dedicated to developing revolutionary platforms based on humanized mice to accelerate discovery and development of Biotechnology/Life Sciences novel therapies. The ground-breaking science was generated from three distinguished In RTP since 2014 laboratories at the Massachusetts Institute of Technology (MIT), the University of North Under 50 employees Carolina (UNC) and Singapore-MIT Alliance for Research and Technology (SMART).

Oak City Tech (919) 628-4071 Headquarters www.oakcity.tech Research Triangle Park, North The Frontier Carolina Oak City Tech is a full service web development and SEO firm with expertise in software 800 Park Offices Drive and application development. We pride ourselves in being group of like minded P.O. Box 3202 Information Technology individuals who care about people and technology. Our passion is for helping business Research Triangle Park, NC In RTP since 2014 stand out in a crowded online environment. With our talented designers we can create 27709 Under 50 employees N modern solutions for small business websites, large e-commerce platforms, logo and graphic design, search engine optimization and WordPress security and maintenance. O

Oerlikon Metco (919) 485-6002 US Headquarters www.oerlikon.com Westbury, New York 12 T.W. Alexander Drive Global Headquarters The division of Oerlikon located in RTP, known as Oerlikon Metco, is a global leader in Building 200, Suite B Balzers, Liechtenstein engineered surface solutions. The RTP location specializes in the application of PVD and P.O. Box 13159 DLC (Diamond Like Carbon) thin film coatings for wear resistance and reduced friction. Research Triangle Park, NC Instruments and Advanced Oerlikon Metco serves a variety of markets including racing, automotive, semiconductor, 27709 Materials plastics and industrial components. In RTP since 1997 Under 50 employees

Inspiring bold ideas™ 50 Optricity Corporation (919) 237-4846 Headquarters www.optricity.com Research Triangle Park, North Alexander Business Suites Carolina Optricity develops best of breed supply chain software focusing on Resource Allocation 68 T.W. Alexander Drive Optimization. Patented solutions include the advanced warehouse slotting optimization P.O. Box 12499 Information Technology tool, OptiSlot DC™, and the warehouse profiling tool, OptiProfile™. Research Triangle Park, NC In RTP since 2013 27709 Under 50 employees

Orion Business Solutions LLC (984) 212-4132 Headquarters Research Triangle Park, North www.orionbizsolutions.com The Frontier Carolina Orion is a product development and venture technology firm. Our focus is on developing 800 Park Offices Drive innovative B2B products for organizations of all sizes and helping other entrepreneurs Suite 3602 Information Technology with their endeavors. Research Triangle Park, NC In RTP since 2017 27709 Under 50 employees

OSSCube (888) 967-7282 Headquarters www.osscube.com Austin, Texas First Flight Venture Center OSSCube is a global solutions provider based in Austin, Texas, with offices in Magnolia, 2 Davis Drive Information Technology Texas, Raleigh-Durham, NC, the UK and India. OSSCube delivers integrated mission-critical Suite 129 In RTP since 2008 business solutions using open source technologies and offers a broad range of services P.O. Box 13169 Under 50 employees including: consulting, elastic virtual development resources, mobile, web and custom Research Triangle Park, NC application development, product support, and open source training. 27709

Palmetto Biomedical (919) 308-9443 Headquarters O www.palmettobiomedical.com Research Triangle Park, North First Flight Venture Center Carolina P Palmetto Biomedical was founded in 2007 by Dr. Lawrence M. Boyd, an international 2 Davis Drive leader in orthopedic medical device innovation. Palmetto Biomedical provides a P.O. Box 13169 Medical Devices and Instruments wide array of design and consulting services in areas such as product development, Research Triangle Park, NC In RTP since 2009 mechanical testing, intellectual property, business development and technology 27709 Under 50 employees evaluation. In addition, Palmetto Biomedical is currently developing medical technology for a variety of orthopedic and neurosurgical applications.

Panacea Solutions (919) 354-1032 Headquarters www.panacea.me Research Triangle Park, North First Flight Venture Center Carolina Our goal is to provide platforms for the development of truly personalized 2 Davis Drive nutraceutieuticals. Panacea Solutions is committed to not only offering products, but also P.O. Box 13169 Pharmaceuticals and Diagnostics knowledge and education. Our goal is to help you move from the standard cure mentality Research Triangle Park, NC In RTP since 2013 to one of prevention and wellness. We stand by our evidence-based solutions. And, while 27709 Under 50 employees bathroom cabinets crammed with tablets are the current standard, Panacea is helping carve a roadway to the next step of truly personalized options.

Inspiring bold ideas™ 51 Park Living Cell The Lab Headquarters www.parklivingcell.com 104 T.W. Alexander Drive, Raleigh, North Carolina Building 4A Research Triangle Park, NC Biotechnology/Life Sciences 27709 In RTP since 2013 Under 50 employees

Pharm-Olam International (919) 237-4300 Headquarters www.pharm-olam.com Research Triangle Park, North 79 T.W. Alexander Drive, Carolina For over 14 years, Pharm-Olam has provided expert advice and services to a variety of 4401 Research Commons biopharma customers in the design, collection, analysis, and reporting of their clinical trials. P.O. Box 14089 Business and Professional Pharm-Olam International supports large and small customers in all phases of development. Research Triangle Park, NC Services 27709 In RTP since 2007 Under 50 employees

Pine Labs The Lab Headquarters www.pinelaboratories.com 104 T.W. Alexander Drive, Research Triangle Park, North Building 7 Carolina Pine Laboratory provides analytical testing and development services for pharmaceutical, Research Triangle Park, NC biopharmaceutical, medical device, cosmetic, food and chemical industries. Pine 27709 Pharmaceuticals and Diagnostics laboratory is a cGMP compliant lab specializing in Ion Chromatography. In RTP since 2014

PrecisionHawk (919) 680-1305 Headquarters www.precisionhawk.com Research Triangle Park, North Research Commons Carolina PrecisionHawk is committed to delivering the highest quality tools to support the delivery 79 T.W. Alexander Drive P of consistent and reliable information to our customers and partners. Additionally, we Research Triangle Park, NC Instruments and Advanced are committed to continually improving the quality of our products and services while 27709 Materials delivering an exceptional customer experience. In RTP since 2015 Under 50 employees

Premier Research 1 Park Drive Headquarters Suite 150 Research Triangle Park, North www.premier-research.com Research Triangle Park, NC Carolina Among the top five Contract Research Organizations (CROs) for consistently delivering 27709 services that meet customer expectations. We have developed a surprising concentration Biotechnology/Life Sciences of experience for a mid-sized CRO: Over 700 trials for virtually every major class of anal- In RTP since 2015 gesic, including every NSAID pain medication on the market today. Approximately 100 rare Under 50 employees disease studies in the past 5 years. Pediatric experience with both familiar and extremely rare childhood illnesses, including work at PICUs, NICUs, clinics, and ERs—and a hard-to- match track record of successful neonatal studies.

Inspiring bold ideas™ 52 ProteoVec, Inc. 6 Davis Drive Headquarters www.proteovec.com Research Triangle Park, NC Baton Rouge, Louisiana 27709 ProteoVec is a privately held biotechnology company with corporate offices in Baton Biotechnology/Life Sciences Rouge, LA. The company is based on recombinant protein manufacturing technology and In RTP since 2014 capabilities which were developed for more than a decade at Louisiana State University Under 50 employees (LSU). Recently, an additional site in Raleigh, North Carolina was opened to concentrate on development and commercialization of the LigaTrap technology.

Purple Goldfish Think Tank (919) 360-4702 Headquarters Research Triangle Park, North www.purplegoldfish.com The Frontier Carolina The Purple Goldfish Think Tank inspires leaders to think differently about their most 800 Park Offices Drive important stakeholders. Our keynotes and workshops focus on the value of customer Suite 3708 Business and Professional experience as a competitive differentiator, the importance of employee engagement Research Triangle Park, NC Services in building a strong corporate culture, and the impact of technology and purpose in 27709 In RTP since 2017 business. We have informed and inspired at over 250 events. We’ve spoken on every Under 50 employees inhabitated continent (US, Canada, UK, Spain, The Netherlands, Russia, France, Australia, Bahrain, Malaysia, Israel, and Sweden) for Fortune 100 brands such as IBM, Target, ESPN, UPS, and Citi. We challenge brands to explore new opportunities, showing them how to be more successful in tomorrow’s changing world. Working with clients to create keynotes and workshops that are memorable, meaningful, and on-brand.

QPS Hepatic Bioscience 6 Davis Drive Headquarters Research Triangle Park, NC Research Triangle Park, North wwww.hepaticbio.comm 27709 Carolina Biotechnology/Life Sciences P In RTP since 2016 Under 50 employees Q R Raleigh Roots LLC The Frontier Headquarters 800 Park Offices Drive Research Triangle Park, North www.raleighroots.com Suite 3516 Carolina Raleigh Roots LLC is a Technology-Research-Education Consulting Practice Partnership Research Triangle Park, NC founded in 2016 by Brad Freeman & Sherry Booth Freeman, PhD 27709 Business and Professional Services In RTP since 2016 Under 50 employees

Inspiring bold ideas™ 53 Research Triangle Foundation of North Carolina (919) 549-8181 Headquarters www.rtp.org Research Triangle Park, North 12 Davis Drive Carolina The Research Triangle Park is managed by the Research Triangle Foundation of North P.O. Box 12255 Carolina. With a vision to help provide a better life for all North Carolinians, the Foundation Research Triangle Park, NC Foundations, Institutes and is focused on orchestrating industry, university and government collaborations to attract 27709 Scientific Associations research, scientific and technology-based organizations and support the creation of In RTP since 1959 quality jobs and opportunities. Through its commitment to fostering a spirit of community, Under 50 employees environmental stewardship, innovation and collaboration, the Foundation invests in programs that cultivate vibrant communities within the Park.

Research Triangle High School (919) 998-6757 Headquarters www.researchtrianglehighschool.org Research Triangle Park, North 3106 NC Highway 54 Carolina Research Triangle High School is a public charter high school offering an innovative P.O. Box 13543 curriculum which blends hands-on experiences with digital materials. Our mission is to Research Triangle Park, NC Foundations, Institutes and increase access to globally competitive STEM education for a broad spectrum of students 27709 Scientific Associations across NC. Opened in August 2012, RTHS will enroll 420 students in grades 9 through In RTP since 2012 12 by 2015. All students are on a college-preparatory track, and all are supported and Under 50 employees fostered to develop the skills needed to succeed in college and in RTP-like careers. Students join RTHS from dozens of middle schools across five counties, creating a truly diverse and committed community.

Reviewgo (855) 832-0185 Headquarters Research Triangle Park, North www.reviewgo.com The Frontier Carolina A revolutionary, managed solution that helps businesses connect with their customers, 800 Park Offices Drive collect more reviews, boost traffic and increase sales all in one place. By utilizing Suite 3615 Business and Professional the power of customers experiences and WiFi, businesses can now truly reach their PO Box 13122 Services customers. Research Triangle Park, NC In RTP since 2015 27709 Under 50 employees R

Inspiring bold ideas™ 54 Ridge Diagnostics (877) 743-4301 Headquarters www.ridgedx.com Research Triangle Park, North First Flight Venture Center Carolina Ridge Diagnostics is a neurodiagnostics company now offering the first blood test to 2 Davis Drive aid in the diagnosis of depression (Major Depressive Disorder). All testing is performed P.O. Box 13169 Pharmaceuticals and Diagnostics in Ridge’s CLIA certified laboratory in Research Triangle Park, NC. The blood test is Research Triangle Park, NC In RTP since 2007 now being made available to physicians through out the country to aid in the diagnosis, 27709 Under 50 employees management and treatment selection for their patients who suffer from depressive symptoms. The company will expand its product offering to include blood tests to determine the efficacy of depressant treatments, as well as a diagnostic test for Bipolar disorder.

RTI International (919) 541-6000 Headquarters 3040 East Cornwallis Road Research Triangle Park, North www.rti.org P.O. Box 12194 Carolina RTI International is an independent, nonprofit institute that provides research, Research Triangle Park, NC development, and technical services to government and commercial clients worldwide. 27709 Foundations, Institutes and RTI’s mission is to improve the human condition by turning knowledge into practice. Scientific Associations Established in 1958 as the Research Triangle Institute, RTI has a distinguished history of In RTP since 1958 scientific achievement in the areas of health and pharmaceuticals, education and training, 1,000 - 4,999 employees surveys and statistics, advanced technology, international development, economic and social policy, energy and the environment, and laboratory testing and chemical analysis. RTI’s staff of more than 3,700 supports projects in more than 75 countries.

RTP Capital Associates, Inc. First Flight Venture Center Headquarters www.rtpcapital.org 2 Davis Drive Research Triangle Park, North P.O. Box 13169 Carolina RTP Capital is an angel investor network investing in early stage growth companies in Research Triangle Park, NC North Carolina and the Southeast. We meet to evaluate early stage opportunities, pool 27709 Business and Professional resources and expertise, socialize,invest and make a difference. Services In RTP since 2010 Under 50 employees R S Schulman IRB (919) 287-4900 Headquarters www.sairb.com Cincinnati, Ohio 10 Laboratory Drive Schulman IRB provides high quality, rigorous IRB reviews for all therapeutic areas and Building #2, Suite 200 Biotechnology/Life Sciences research phases in North America via streamlined processes, customized technology and P.O. Box 110184 In RTP since 2015 responsive customer service. We provide dedicated, AAHRPP-accredited IRB services Research Triangle Park, NC Under 50 employees for sponsors, CROs, research institutions and sites and have an unparalleled clean audit 27709 history with FDA. We also offer global CQA and HRP consulting via our partner Provision Research Compliance Services.

Inspiring bold ideas™ 55 SciKon Innovation, Inc. (919) 354-1083 Headquarters www.scikoninnovation.com Research Triangle Park, North First Flight Venture Center Carolina SciKon’s mission is to bring microphysiological systems to the masses. SciKon’s core 2 Davis Drive competency is in both systems engineering and systems biology. Our team has a P.O. Box 13169 Biotechnology/Life Sciences significant background in engineering, with requisite expertise in applied cell biology and Research Triangle Park, NC In RTP since 2009 medical research. Our collective knowledge has driven tools and reagent development 27709 Under 50 employees from a biology perspective along with a systems engineering approach to achieve products for replicating human organ systems connected through microfluidics. SciKon’s microfluidic cell culture device improves the ability to predict human responses to drugs and toxicants using cell-based technologies in an accessible format.

Sciome, LLC First Flight Venture Center Headquarters www.sciome.com 2 Davis Drive Research Triangle Park, North P.O. Box 13169 Carolina Sciome, LLC is an innovative research and technology consulting company providing Research Triangle Park, NC state of the art informatics solutions for the life sciences industry. Sciome specializes 27709 Information Technology in developing and deploying novel bioinformatics and chemoinformatics solutions for In RTP since 2010 researchers in government, academic and private sector organizations. Our expertise Under 50 employees includes data integration, data mining, helpdesk support and analytical informatics.

ScitoVation LLC 6 Davis Drive Headquarters Research Triangle Park, NC Research Triangle Park, North www.scitovation.com 27709 Carolina ScitoVation provides clients with the science, technical expertise and technology to understand how chemical compounds affect human health. Known for partnership, Biotechnology/Life Sciencess flexibility and proven success, we help clients develop safer and more effective In RTP since 2017 pharmaceuticals, food ingredients, agricultural chemicals, commodity chemicals, Under 50 employees and consumer products. We are recognized as industry experts in cell-based and computational methods who answer profound questions and provide leading-edge solutions for our clients. S Sigma Xi, The Scientific Research Society (919) 549-4691 Headquarters www.sigmaxi.org Research Triangle Park, North Progress Center Carolina Sigma Xi, The Scientific Research Society is a nonprofit international honor society founded 3200 NC Highway 54 in 1886 with more than 530,000 scientists and engineers inducted in to the society based Suite 300 Foundations, Institutes and on their research achievements. Sigma Xi has hundreds of multi-disciplinary chapters P.O. Box 13975 Scientific Associations at universities and colleges, government laboratories and industry research centers. In Research Triangle Park, NC In RTP since 1990 addition to publishing American Scientist magazine, Sigma Xi awards research grants 27709 50 - 99 employees annually to promising young scientists and engineers, holds scientific research forums and sponsors a variety of educational programs supporting honor in science and engineering research, science ethics education, science policy and the public understanding of science.

56 SiNON Therapeutics 2 Davis Drive Headquarters Research Triangle Park, NC Research Triangle Park, North www.sinontp.com 27709 Carolina SiNON is dedicated to improving the lives of those who suffer from debilitating neurological diseases by increasing the ability of drugs to cross the Blood Brain Barrier Biotechnology/Life Sciences (BBB). Our patented Nano-Particle, the Carbon Dot, will enable pharmaceutical companies In RTP since 2016 to encapsulate their drugs in a way which dramatically improves drug-localization to the Under 50 employees brain. This allows for a reduction in overall dose administration to the patient, leading to reduced toxicity risk and side-effects while improving Therapeutic Index and cost- efficacy. Considering the rapid growth of the senior population, and subsequent increase in neurological disease, we believe that our novel technology is an essential part of the overall solution to this healthcare crisis in the US and around the World.

Sirga Advanced Biopharma, Inc (919) 354-1008 Headquarters Research Triangle Park, North www.sirgaab.com First Flight Venture Center Carolina Sirga is an early-phase drug discovery company focused on novel targets of pathogens 2 Davis Drive (bacterial, fungal and viral) that are difficult for the pathogenic organism to alter, thus P.O. Box 13169 Biotechnology/Life Sciences reducing the potential for drug resistance. Research Triangle Park, NC Pharmaceuticals and Diagnostics 27709 In RTP since 2008 Under 50 employees

Society of Biomolecular Imaging and Informatics (919) 558-1200 Headquarters www.sbi2.org Research Triangle Park, North 6 Davis Drive Carolina The Society of Biomolecular Imaging and Informatics (SBI2) is an international community P.O. Box 12300 of leaders, scientists, and students promoting technological advancement, discovery, Research Triangle Park, NC Foundations, Institutes and and education to quantitatively interrogate biological models to provide high context 27709 Scientific Associations information at the cellular level. In RTP since 2013 Under 50 employees

SonoVol First Flight Venture Center Headquarters S www.sonovol.com 2 Davis Drive Research Triangle Park, North Research Triangle Park, NC Carolina SonoVol is a spinout from the Joint Department of Biomedical Engineering at UNC 27709 Chapel Hill and North Carolina State University. Company co-founders Dr. Paul Dayton Biotechnology/Life Sciences and Dr. Ryan Gessner have worked together since 2008, and have developed numerous In RTP since 2014 ultrasound-imaging hardware and software technologies which have direct commercial Under 50 employees application to several disease research markets. SonoVol was founded in in 2012, and to date the team has completed the assembly and testing of their prototype imaging system. SonoVol’s mission is to lower the barrier of entry for every biologist that needs to perform preclinical screening or acquire longitudinal in vivo data in the pharmaceutical, biotech, government and academic markets.

57 Sotomayor IP Consulting, Ltd. (919) 610-6872 Headquarters Research Triangle Park, North www.sotoip.com The Frontier Carolina Based in Research Triangle Park (RTP), our firm focuses on protecting client innovation 800 Park Offices Drive assets through the patent process. Our founder, John Sotomayor, is formerly in-house Suite 3506 Business and Professional patent counsel for high-tech companies in the Triangle, is a former Patent Examiner with Research Triangle Park, NC Services the USPTO, and spent the first half of his career as an electrical engineer in the energy, 27709 In RTP since 2017 telecommunications, software and intelligence industries. Areas of specialization include Under 50 employees software, cybersecurity, IP strategy, and competitive landscape analysis.

Southcot, Inc. (919) 260-6398 Headquarters www.hypoxyprobe.com Chapel Hill, North Carolina The Lab Southcot, Inc. is a start-up company specializing in tissue oxidative stress with current 104 T.W. Alexander Drive Pharmaceuticals and Diagnostics emphasis on producing new exogenous hypoxia markers for the detection of hypoxia Building 5, Room 506 In RTP since 2006 at the cell level in diseased, normal and malignant tissues. Strategic affiliations and Research Triangle Park, NC Under 50 employees collaborations have been established with NPI, Inc in Burlington, Massachusetts; UNC- 27709 Chapel Hill; Duke University; and NC State University College of Veterinary Medicine. Reagents for both animal and human diagnostics are currently being developed.

Spyryx Biosciences TUCASI Headquarters www.spyryxbio.com 15 T.W. Alexander Drive Research Triangle Park, North Research Triangle Park, NC Carolina Spyryx Biosciences is developing next generation therapeutics for obstructive 27709 lung diseases with a particular focus on Cystic Fibrosis and COPD. We are dedicated Biotechnology/Life Sciences to making a difference in the lives of patients and their families who bravely face these In RTP since 2015 diseases every day. Under 50 employees

Stiefel, a GSK Company (919) 990-6000 Headquarters www.stiefel.com Research Triangle Park, North 20 T.W. Alexander Drive Carolina Stiefel, a GSK company, is committed to advancing dermatology and skin sciences around Research Triangle Park, NC the world in order to help people better achieve healthier skin. Stiefel’s dedication to 27709 Pharmaceuticals and Diagnostics S innovation, along with its sole focus on dermatology, has established Stiefel as a world In RTP since 2006 leader in the skin health industry. 100 - 249 employees

StrataBuilt The Frontier Headquarters Research Triangle Park, North We’re a dedicated, collaborative group of individuals that specialize in custom software 800 Park Offices Drive development and agile consulting 3rd Floor Carolina Research Triangle Park, NC Vascular Pharmaceuticals: Vascular Pharmaceuticals, Inc. is a private biopharmaceutical 27709 Information Technology company working to address the complications of diabetes, specifically diabetic In RTP since 2016 nephropathy. There is a serious unmet need for effective treatments for this patient Under 50 employees population, which includes both Type 1 and Type 2 diabetics.

58 Strensor Systems First Flight Venture Center Headquarters www.strensorsystems.com 2 Davis Drive Research Triangle Park, North Research Triangle Park, NC Carolina Strensor Systems develops metamaterials for shielding low frequency fields such as 27709 the ones used for metal detection in food manufacturing, thereby improving reliability Information Technology and accuracy of detection in order to prevent harm to consumers, machinery, company In RTP since 2014 reputation, as well as reducing processing downtime and food waste. Under 50 employees

Symmetry Biosciences (919) 314-5545 Headquarters www.symmetrybiosciences.com Research Triangle Park, North The Lab Carolina Symmetry Biosciences, Inc. is a specialized contract research organization that offers 104 T.W. Alexander Drive innovative solutions to medicinal chemistry, process chemistry and related areas to Building 4 Pharmaceuticals and Diagnostics biotechnology, pharmaceutical, medical device, agrochemical and fine chemical industries. P.O. Box 14529 In RTP since 2010 Research Triangle Park, NC Under 50 employees 27709

Syngenta Crop Protection, LLC (919) 541-8500 US Headquarters www.syngentabiotech.com Greensboro, North Carolina 3054 East Cornwallis Road Global Headquarters Syngenta Biotechnology, Inc. is a world leading agribusiness committed to sustainable P.O. Box 12257 Basel, Switzerland agriculture through innovative research and technology. The company is a leader in crop Research Triangle Park, NC protection and ranks third in the high-value commercial seeds market. Innovation is the 27709 Biotechnology/Life Sciences lifeblood of Syngenta and delivering innovation is the focus of scientists at Syngenta Agricultural Biosciences Biotechnology. In RTP, Syngenta researchers use a combination of science and cutting- In RTP since 1984 edge technology to develop innovative solutions that help farmers grow more from less. The company is in the midst of a $71 million expansion of its RTP operations. 250-499 employees

Synnovator, Inc. (919) 314-5563 Headquarters www.thesynnovator.com Research Triangle Park, North The Lab Carolina We are specialized in providing Azetidine, Cyclobutane , and Oxetane chemicals, Spiro 104 T.W. Alexander Drive chemicals, Piperidine and Tetrahydropyran chemicals, Pyrrolidine and Tetrahydrofuran Building 1 Biotechnology/Life Sciences S chemicals, and Indole and Indazole chemicals. Currently, we have over 5,000 in-stock P.O. Box 110527 In RTP since 2012 building blocks. By owning large vendor resources, we provide fast and reliable products Research Triangle Park, NC Under 50 employees at unbeatable rates. 27709

Inspiring bold ideas™ 59 Synsei Medical (919) 794-7898 Headquarters www.synseimedical.com Research Triangle Park, North First Flight Venture Center Carolina Synsei Medical was founded with the goal, passion, and commitment to advance the 2 Davis Drive practice of maternal and fetal monitoring. With more women between the ages of 40 to P.O. Box 13169 Medical Devices and Instruments 44 giving birth and having twins, along with the risk of high blood pressure, preeclampsia, Research Triangle Park, NC In RTP since 2014 and gestational diabetes during pregnancy, it is essential to provide reliable, quantitative, 27709 Under 50 employees non-invasive methods of monitoring multiple fetuses and maternal health. What is more, mobile monitoring promises to lower costs and provide better access to care to remote locations, especially for those who do not have access to obstetric specialists, and to improve hospital workflow and efficiencies.

T3D Therapeutics Inc. (919) 237-4897 Headquarters www.t3dtherapeutics.com Alexander Business Suites Research Triangle Park, North 68 T.W. Alexander Drive Carolina T3D Therapeutics’ mission, as a pharmaceutical R&D company, is to develop and Research Triangle Park, NC commercialize T3D-959, potentially an optimal disease remedial therapeutic for the 27709 Biotechnology/Life Sciences treatment of Alzheimer’s Disease. Unlike single dimension therapies in development that In RTP since 2013 target one abnormality (i.e. pathology), for example beta amyloid plaques or tau bundles, Under 50 employees this oral once-a-day therapy acts in a multidimensional manner. As a dual nuclear receptor agonist, T3D-959 may regulate a myriad of genes involved in Alzheimer’s disease pathologies and thus may offer a greater potential to slow, stop or reverse disease progression.

Telemanagement Resources International Inc. Alexander Business Suites Headquarters www.triinc.com 68 T.W. Alexander Drive Manahawkin, New Jersey Research Triangle Park, NC Telemanagement Resources International Inc. (TRI) is an organization of individuals who 27709 Business and Professional are consultants with expertise in diverse areas. Each member of the TRI team has proven Services experience providing effective telecommunications, marketing, and training counsel to In RTP since 2014 clients in business, education, and government worldwide. Under 50 employees

TEM Systems, Inc Research Triangle Park, NC Headquarters 27709 Research Triangle Park, North S www.rotem-usa.com Carolina T Biotechnology/Life Sciences In RTP since 2016 Under 50 employees

Inspiring bold ideas™ 60 Tetra Tech, Inc. (919) 485-8278 Headquarters www.tetratech.com One Park Drive Pasadena, California P.O. Box 14409 Tetra Tech, Inc. provides specialized management consulting and technical services Research Triangle Park, NC Clean and Green Technologies in resource management, infrastructure and communications. Tetra Tech’s RTP office 27709 In RTP since 1996 specializes in Water Resources Management including watershed assessment, GIS and Under 50 employees computer model applications, TMDLs management planning, implementation support, site evaluations and Low Impact Design public outreach and training.

The Divitias Group The Frontier Headquarters 800 Park Offices Drive Research Triangle Park, North Research Triangle Park, NC Carolina 27709 Business and Professional Services In RTP since 2016 Under 50 employees

Toshiba Global Commerce Solutions 3039 East Cornwallis Road, Headquarters www.toshibacommerce.com Building 307 Research Triangle Park, North P.O. Box 12195 Carolina Toshiba Global Commerce Solutions is retail’s first choice for integrated in-store solutions. Research Triangle Park, NC We are the leading supplier of point-of-sale solutions with a worldwide install base larger 27709 Information Technology than any three major competitors combined. Toshiba is committed to delivering innovative In RTP since 2012 commerce solutions that transform checkout, provide seamless consumer interactions 500 - 999 employees and optimize retail operations. With a global team of dedicated business partners, Toshiba provides end-to-end solutions, service and support that help clients meet virtually any retail technology need.

TransCirrus (800) 649-0704 Headquarters www.transcirrus.com Research Triangle Park, North First Flight Venture Center Carolina TransCirrus helps remove the barriers to cloud computing by introducing a user-friendly, 2 Davis Drive cost effective, simple, and scalable private cloud solution based on a preconfigured Research Triangle Park, NC Information Technology OpenStack® cloud in a box appliance. The solution is based on Red Hat’s version of 27709 In RTP since 2015 T OpenStack® and is readily available in the market right now. If you want an OpenStack® Under 50 Employees cloud solution that is up and running in minutes, just let us know.

Inspiring bold ideas™ 61 Triangle ArtWorks The Frontier Headquarters www.triangleartworks.org 800 Park Offices Drive Research Triangle Park, North Suit 3218 Carolina Triangle ArtWorks is based on the belief that a vibrant Triangle Region is one in which Research Triangle Park, NC members of the arts community are not only appreciated for their work, but paid for their 27709 Foundations, Institutes and work and recognized as a vital economic segment. Our mission is to support, promote Scientific Associations and advocate for and to increase the strength of this community by giving it a platform In RTP since 2015 and network to come together and connect as a business community. We are working Under 50 employees collaboratively with other arts, small business and economic development groups to ensure that the arts community continues to be strong, diverse and financially sustainable.

Triangle Community Foundation The Frontier Headquarters 800 Park Offices Drive Research Triangle Park, North www.trianglecf.org Suite 201 Carolina Triangle Community Foundation envisions a community where everyone has the Research Triangle Park, NC opportunity to thrive, and we are uniquely positioned to connect donors, nonprofits, 27709 Foundations, Institutes and leaders and individuals to make a difference. We have been right here for the last 33 Scientific Associations years, growing and changing along with our region – and we will continue to be here for In RTP since 2016 the next 33 years and beyond. Under 50 employees Foundation Medicine: Our products provide more than information. They offer hope to patients, their families and friends, their physicians and caregivers. This understanding defines our culture, drives our teams, and motivates every one of us to strive for excellence in everything we do. Triangle Research Laboratories, LLC (919) 549-3593 Headquarters www.triangleresearchlabs.net Research Triangle Park, North 6 Davis Drive Carolina Triangle Research Labs (TRL) produces high quality hepatocytes for use in pre-clinical P.O. Box 14453 ADMETox applications. TRL provides both human and animal, fresh and cryopreserved Research Triangle Park, NC Pharmaceuticals and Diagnostics hepatocytes, and other related products. TRL has decades of experience in the hepatic 27709 In RTP since 2011 sciences and is a leader in quality and service in the industry. Under 50 employees

Triangle Ultimate (919) 907-1279 Headquarters www.triangleultimate.org Research Triangle Park, North The Frontier Carolina Triangle Ultimate’s mission is to increase the quality and quantity of ultimate programs 800 Park Offices Drive, T for all ages and skill levels, with a special emphasis on youth development. By providing P 3308 Service Providers players, coaches, and volunteers opportunities to learn, play, and teach spirited ultimate, Research Triangle Park, NC In RTP since 2016 we aim to strengthen the ultimate community of the Triangle. 27709 Under 50 employees

Inspiring bold ideas™ 62 Trio Labs, Inc 2 Davis Drive Headquarters Research Triangle Park, NC Research Triangle Park, North www.trio-labs.com 27709 Carolina Trio Labs has developed innovative Additive Manufacturing (AM) technology that will revolutionize industries’ ability to create and produce high quality precision plastic, metal Instruments and Advanced and ceramic prototypes, tools and components at incredible speeds that are not available Materials in today’s market place. In RTP since 2016 Under 50 employees

Triumfant, Inc. (919) 248-9393 Headquarters www.triumfant.com Rockville, Maryland 79 T.W. Alexander Drive, Triumfant, Inc. offers revolutionary, one-of-a-kind software that detects, analyzes and 4401 Research Commons Information Technology remediates changes in endpoint machines and servers, enabling Triumfant to identify Suite 205 In RTP since 2002 and remediate malicious attacks and continuously enforce security configurations. This P.O. Box 12798 Under 50 employees approach eliminates the reliance on prior knowledge and allows Triumfant to see the Research Triangle Park, NC constantly evolving attacks that government agencies and businesses face today such as 27709 zero day attacks and the attacks characterized by the Advanced Persistent Threat.

Troxler Electronic Laboratories, Inc. (919) 549-8661 Headquarters www.troxlerlabs.com Research Triangle Park, North 3008 Cornwallis Road Carolina Founded in 1958, Troxler Electronic Laboratories, Inc. is dedicated to developing, P.O. Box 12057 manufacturing and servicing precision quality control and measurement equipment for the Research Triangle Park, NC Instruments and Advanced worldwide highway and construction industry. Troxler’s comprehensive portfolio of field 27709 Materials and laboratory products includes nuclear moisture and density gauges, electromagnetic In RTP since 1974 materials-measurement devices, gyratory compactors, infrared ovens and instruments for Under 50 employees measuring specific gravities of asphalt mixtures. With the highest quality instrumentation backed by the most reliable domestic and international customer service and support, Troxler continues to be the most trusted name in quality control and quality assurance for the construction industry.

UAI Technology, Inc. (919) 541-9339 Headquarters www.alexanderRTP.com Research Triangle Park, North 68 T.W. Alexander Drive Carolina UAI Technology, Inc., established in 1978, is involved in a number of business activities. P.O. Box 13628 T In addition to its operating business, UAI established Alexander Business Suites in its Research Triangle Park, NC Information Technology U RTP headquarters. These suites provide attractive options for firms looking to locate in 27709 In RTP since 1985 the Research Triangle Park and rent full-service offices with flexible lease terms. UAI’s Under 50 employees University Conference Services division produces nationally acclaimed educational conferences in the fields of retirement plans, health care and treasury management. UAI’s Phoenix-Hecht division develops databases, software and market research in the corporate cash management field. Phoenix-Hecht products are utilized by most major banks in the United States.

Inspiring bold ideas™ 63 UL LLC 12 Laboratory Drive Headquarters www.ul.com P.O. Box 13995 Northbrook, Illinois Research Triangle Park, NC Underwriters Laboratories, Inc. (UL) is the trusted source across the globe for product 27709 Instruments and Advanced compliance. Benefiting a range of customers from manufacturers and retailers to Materials consumers and regulating bodies, UL has tested products for the public safety for more In RTP since 1986 than a century. 250 - 499 employees

United States Environmental Protection Agency 109 T.W. Alexander Drive Headquarters Research Triangle Park, NC Washington, District of Columbia (US-EPA) 27709 www.epa.gov Clean and Green Technologies The United States Environmental Protection Agency (U.S.-EPA) laboratories and offices In RTP since 1971 develop analytical tools and models used to assess pollutant exposure; investigate human 1,000 - 4,999 employees and ecological effects of environmental pollutants; utilize engineering approaches to mitigate or limit industrial and indoor air pollution; develop guidelines for performing human health and ecological risk assessments; and manage national programs for maintaining air quality.

United Therapeutics Corporation (919) 485-8350 Headquarters www.unither.com Silver Spring, Maryland 55 T.W. Alexander Drive United Therapeutics Corporation is a biotechnology company focused on the P.O. Box 14186 Pharmaceuticals and Diagnostics development and commercialization of unique products to address the unmet medical Research Triangle Park, NC In RTP since 1996 needs of patients with chronic and life-threatening conditions. 27709 250 - 499 employees

The University of North Carolina Center (919) 549-7000 Headquarters Research Triangle Park, North for Public Television (UNC-TV) 10 T.W. Alexander Drive Carolina www.unctv.org P.O. Box 14900 Member-supported University of North Carolina Center for Public Television (UNC-TV) is Research Triangle Park, NC Business and Professional North Carolina’s only statewide public television network, made possible through a unique 27709 Services partnership of public investment and private support. UNC-TV’s mission isto provide North In RTP since 1989 Carolinians of all ages with life-changing television. 100 - 249 employees

USDA Forest Service Southern Research Station (919) 549-4000 Headquarters U www.srs.fs.usda.gov Washington, District of Columbia 3041 East Cornwallis Road The USDA - Forest Service Southern Research Station in Research Triangle Park provides P.O. Box 12254 Biotechnology/Life Sciences basic and applied forest research in economics, soils, global climate change and forest Research Triangle Park, NC In RTP since 1962 health, productivity, and sustainability. 27709 Under 50 employees

Inspiring bold ideas™ 64 Vascular Pharmaceuticals, Inc 79 T.W. Alexander Drive & Headquarters 4401 Research Commons, Research Triangle Park, North www.vascularpharma.com Suite 200A Carolina Research Triangle Park, NC 27709 Biotechnology/Life Sciences In RTP since 2016 Under 50 employees

ViiV Healthcare (877) 844-8872 US Headquarters www.viivhealthcare.com Research Triangle Park, North 5 Moore Drive Carolina ViiV Healthcare is a global specialist dedicated to delivering advances in treatment Research Triangle Park, NC Global Headquarters and care for people living with HIV. We are an independent pharmaceutical company 27709 Middlesex, United Kingdom established in 2009 by combining the power and expertise in the management of HIV from both GlaxoSmithKline (GSK) and Pfizer. Following a long-term collaboration on the joint Pharmaceuticals and Diagnostics development of several novel integrase inhibitors we were joined by Shionogi in 2012. Our In RTP since 2009 current portfolio of eleven HIV treatments generated annual sales of £1.4 billion in 2012. Our scientists are 100% dedicated to finding new ways to limit the impact of HIV on the 34 Under 50 employees million people living with the virus and understanding how best to prevent and treat the disease.

Vijaya Pharmaceuticals LLC (919) 314-5528 Headquarters www.vijayapharma.com Research Triangle Park, North The Lab Carolina Vijaya Pharmaceuticals, LLC (V-PHARMA) is a dynamic, cutting edge drug discovery 104 T.W. Alexander Drive research company that provides a wide range of medicinal chemistry and synthetic Building 5 Pharmaceuticals and Diagnostics organic chemistry services. V-PHARMA is a reliable partner for providing innovative P.O. Box 14547 In RTP since 2009 solutions to the clients. The services would include: full-time equivalent (FTE), medicinal Research Triangle Park, NC Under 50 employees chemistry, and synthetic organic chemistry, custom synthesis of the advanced 27709 intermediates, synthesis of reference standards, and drug discovery through a risk-sharing partnership. V-PHARMA can offer cutting-edge solutions to the drug discovery programs including securing the intellectual property rights for an exciting program.

ViraSource (919) 354-1023 Headquarters www.virasource.com Research Triangle Park, North First Flight Venture Center Carolina ViraSource’s objective is to provide the highest quality materials and support for virology 2 Davis Drive U and immunology research. ViraSource scientists have extensive experience in virology, P.O. Box 13169 Biotechnology/Life Sciences cell biology and immunology. Research Triangle Park, NC In RTP since 2010 V 27709 Under 50 employees

Inspiring bold ideas™ 65 ViraTree First Flight Venture Center Headquarters www.viratree.com 2 Davis Drive Research Triangle Park, North Research Triangle Park, NC Carolina ViraTree is a start-up company specializing in virology reagents and services. Its mission is 27709 to acquire, authenticate, preserve, develop, and distribute innovative virological materials, Biotechnology/Life Sciences information, and technology for the advancement and application of virus research. In RTP since 2014 ViraTree provides its products and services to research laboratories in universities, Under 50 employees medical facilities, and biotech companies around the world. We also offer a platform for investigators to contribute their unique viruses and aportion of the revenue generated is shared with the investigators’ labs.

Webonise Lab Research Commons Headquarters www.webonise.com 79 T.W. Alexander Drive Research Triangle Park, North Research Triangle Park, NC Carolina @webonise 27709 Webonise Lab is a world wide product development and services company with a curious Information Technology and passionate team of software engineers, usability experts and business analysts. We In RTP since 2015 are a fun, talented, team who loves working together and we have a passion for building Under 50 employees remarkable software that people love.

WhiteSpace Health, Inc. (919) 907-2066 Headquarters www.whitespacehealth.com Research Triangle Park, North First Flight Venture Center Carolina WhiteSpace Health is a provider of data analytics and cloud-based healthcare intelligence. 2 Davis Drive Our solutions and technologies integrate all the data points and convert them to effective Research Triangle Park, NC Information Technology actionable KPIs. Our passion is to provide solutions that will help providers prepare for 27709 In RTP since 2014 rapidly changing landscape and consumerization of healthcare. Under 50 employees

Wolfspeed, a Cree Company (919) 407-5331 Headquarters www.wolfspeed.com Research Triangle Park, North 3028 Cornwallis Road Carolina @wolfspeed P.O. Box 12713 Wolfspeed is the world’s leading innovator and manufacturer of wide bandgap Research Triangle Park, NC Medical Devices and Instruments semiconductors, which have been proven to be superior to incumbent technologies 27709 In RTP since 2015 in conserving, converting and utilizing energy. Our power devices provide increased 250 - 499 employees efficiency, higher switching frequency and reduced system size and weight in a variety of applications in the communications, industrial, energy and transportation markets. Wolfspeed RF Products use GaN on silicon carbide. GaN-on-SiC provides inherent V advantages that significantly benefit Wolfspeed customers - including higher efficiency, wider bandwidth, higher power and smaller size. We serve customers in multiple markets W including military and aerospace, communications and industrial applications.

Inspiring bold ideas™ 66 XinRay Systems Inc. (919) 313-9685 Headquarters www.xinraysysytems.com Research Triangle Park, North Alexandria Innovation Center Carolina XinRay Systems Inc develops and manufactures distributed x-ray sources for a broad 7020 Kit Creek Road range of applications including diagnostic medical imaging, homeland security and Suite 210 Instruments and Advanced industrial inspection. P.O. Box 12848 Materials Research Triangle Park, NC In RTP since 2007 27709 Under 50 employees

Xintek, Inc. (919) 313-9638 Headquarters www.xintek.com Delaware, DE, USA Alexandria Innovation Center Xintek, Inc. develops nanomaterial-based field emission technologies and products for a 7020 Kit Creek Road Instruments and Advanced broad range of industries such as x-ray imaging, information display, telecommunication, P.O. Box 13788 Materials aerospace and oil detection. Xintek’s major products include: carbon nanotube (CNT) Research Triangle Park, NC Under 50 employees based field emission electron source, field emission grade CNT material, field emission 27709 x-ray source and CNT AFM probes. The company also conducts contracted R&D mainly on CNT field emission applications.

Xona Microfluidics, LLC 2 Davis Drive Headquarters Research Triangle Park, NC Temecula, California www.xonamicrofluidics.com 27709 We provide to the neuroscience research community unique, disposable platforms Biotechnology/Life Sciences to sustain viability in vitro to cellular organization. Our neuron devices provide In RTP since 2016 compartmentalization, fluidic isolation and improved cellular organization over traditionally Under 50 employees chaotic neuronal cell cultures.

Zen-Bio, Inc. (919) 547-0692 Headquarters www.zen-bio.com Research Triangle Park, North 3200 NC Highway 54, Carolina Zen-Bio, Inc. is a leading global provider of advanced cell-based solutions and services Cape Fear Building, Suite 100 to the life science, cosmetics, and personal care communities. The company, founded P.O. Box 13888 Pharmaceuticals/Diagnostics in 1995, was a pioneer in adipose derived stem cells (ASCs) and continues this legacy Research Triangle Park, NC Instruments and Advanced by providing cutting edge human primary cell culture products and services. Zen-Bio’s 27709 Materials mission is to provide the highest quality human cell systems, reagents and contract In RTP since 1995 services to our research partners, to develop and commercialize innovative research tools. Under 50 employees

X Y Z

Inspiring bold ideas™ 67 ZumaTek, Inc. (919) 225-3965 Headquarters www.zumatek.com Research Triangle Park, North First Flight Venture Center Carolina Current breast screening technologies are inadequate for accurate early detection of 2 Davis Drive breast cancer and are notoriously uncomfortable to the point of pain due to compression. Suite 508 Medical Devices and Instruments Researchers at Duke University Medical Center founded ZumaTek, Inc. for the purpose P.O. Box 13169 In RTP since 2009 of commercializing a platform of innovative, patient-friendly dedicated breast scanners Research Triangle Park, NC Under 50 employees designed to detect the presence of breast cancer much earlier than current technologies. 27709 3D breast CT offers a screening solution to more accurately screen for breast cancer while doing so in a more patient-friendly manner by eliminating the need for breast compression.

Zy Therapeutics, Inc 104 T.W. Alexander Drive Headquarters Research Triangle Park, North ZY Therapeutics is developing a drug delivery platform for cancer therapeutics using Research Triangle Park, NC nanotechnology. 27709 Carolina Biotechnology/Life Sciences In RTP since 2016 Under 50 employees

Z

Inspiring bold ideas™ 68 # Blackstone Entrepreneurs Network D BlocLedger Inc. Danfoss Drives 21st Century Creations Bluecell Energy DellEMC Bright Horizons at RTP Delta Products Corporation Bright Horizons at The Enrichment Center A Dharma Laboratories, LLC Brite Bio, Inc. Dignify Therapeutics Aerie Pharmaceuticals, Inc. Bunker Labs RDU DILIsym Services AgBiome Burroughs Wellcome Fund Agile EndoSurgery DOCS AgTech Accelerator Corporation DTS Language Services, Inc. Alera Labs LLC C DuPont Electronics and Communications Alexander Business Suites Camras Vision Alion Science and Technology Corporation Cell Microsystems E All About Beer, LLC Centauri Surgical Systems EatDrinkDeals.com American Association of Textile Centers for Disease Control and Prevention ECS Federal, Inc. Chemists and Colorists Center for Innovation Management Studies EHR 2.0 ARBIOM Center for International Understanding Edstar Analytics, Inc. Army Research Office CertiRx Corporation Eisai, Inc. Ascent Bio-Nano Technologies Chaperone Therapeutics, Inc. ElectroChemical Systems, Inc. Atlantic Pharmaceuticals Ltd ChemoGenics BioPharma Endacea, Inc. Attagene, Inc. ChemQ Bioscience LLC Entegrion, Inc. Avazyme, inc Ciena Corporation EntreDot Avertica Cisco Systems, Inc. ENVIGEN Pharmaceuticals Avioq, Inc. Clairvoyant Networks LLC Ericsson AXA Advisors Cleanvolt Energy EthosExcel Clinical Sensors, Inc. Eton Bioscience Clinical Ambassador B Exam Design Inc. Cloud Pharmaceuticals, Inc. Excelerate Health Ventures BA3 LLC Cnanoz Inc Exinent Bank of America Compass Datacenters BaseTrace Connecture Inc. BASF Corporation Copernicus Group IRB F Bayer CropScience Couragen Biopharmaceutics, LLC INDEX: COMPANIES, ALPHABETICAL INDEX: COMPANIES, Family Health Network BD Technologies CraZBrain, LLC Fennec Pharmaceuticals Inc. Benson Hill Biosystems, Inc. Creative PEGWorks Fidelity Investments BHV Pharma, Inc. Creative Scientist First Citizens Bank BindusChem Credit Suisse First Environments Early Learning Center Biogen Idec Cree, Inc. First Flight Venture Center bioMASON CrossView, Inc. FMC Corporation BioMedomics, Inc. CSC Systems Forse, Inc. bioMONTR Labs Curasan Inc Foundation Medicine BioShape Solutions CytoFlow, LLC

69 Freudenberg IT LP (FIT) International Union of Pure & Applied Chemistry Mokobio Biotechnology Group FujiFilm Diosynth Biotechnologies i-xploremyhealth Monsanto Corporation Motor & Equipment Manufacturers Association Murano Corporation G J myDrugCosts, Inc. G1 Therapeutics JMC (USA), Inc. Galaxy Diagnostics, Inc. Jobacuda LLC GEAR UP NC N GENBAND National Computing Center Genetron Health K National Humanities Center GENEWIZ Kate Pope Photography National Inc.lusion Project Gift Boogle KBI Biopharma National Institute of Environmental Gilbarco Veeder-Root Koolbridge Solar Inc Health Sciences GlaxoSmithKline National Institute of Statistical Sciences GlobalSubmit, Inc. National Toxicology Program Goldfinch Sensor Technolies and Analytics LLC L NC Biotechnology Center GoSell Lenovo NC Families Accessing Services Grifols LifeNet Health Through Technology GW Pharmaceuticals Linde NC GlaxoSmithKline Foundation Live Gamer NC Healthcare Information and Lucideon Communications Alliance H NC New Schools Heteroz, Inc. NC State Education Assistance Authority Hi Fidelity Genetics M NC State University MBA@RTP Humacyte Market Technologies Inc. NC State - UNC Joint Department of Maverick Synfuels Biomedical Engineering MCNC NephroGenex Inc. I Medicago NetApp, Inc. IBM Corporation Linde Network Development Group ICON Clinical PLC Live Gamer NeuroRepair Therapeutics, Inc iEssence Tech Inc. Lucideon New River Investments Impact Pharmaceutical Services, Inc. Luzverde Partners NIRvana Sciences, Inc. Inanovate INDEX: COMPANIES, ALPHABETICAL INDEX: COMPANIES, Market Technologies Inc. Novartis Vaccines Indexus Biomedical LLC Maverick Synfuels NovaTarg, Inc. Inivata Inc. MCNC NOVO, LLC Intarcia Therapeutics, Inc Medicago Novocor Medical Systems Integrated Technical Services Memscap, Inc. Novozymes Integrated Training Solutions, Inc. MethodSense, Inc. Novus Energy Technologies, Inc. Intelligaia Microelectronics Assembly Technologies NPBiosciences International Services Assistance Fund Micross Components International Society of Automation Mispro Biotech Services

70 SiNON Therapeutics O V Sirga Advanced Biopharma, Inc. Oak City Tech Society of Biomolecular Imaging and Informatics Vascular Pharmaceuticals, Inc Oerlikon Metco SonoVol ViiV Healthcare Optricity Corporation Sotomayor IP Consulting, Ltd. Vijaya Pharmaceuticals LLC Orion Business Solutions LLC Southcot, Inc. ViraSource ViraTree OSSCube Spyryx Biosciences Stiefel, a GSK Company StrataBuilt W P Strensor Systems Webonise Lab Palmetto Biomedical Symmetry Biosciences Wells Fargo Panacea Solutions Syngenta Biotechnology, Inc. WhiteSpace Health, Inc. Park Living Cell Synnovator, Inc. Pharm-Olam International Synsei Medical X Pine Labs XinRay Systems Inc. PrecisionHawk Xintek, Inc Premier Research T Xona Microfluidics, LLC ProteoVec, Inc. T3D Therapeutics Inc. Purple Goldfish Think Tank Telemanagement Resources International Inc. TEM Systems, Inc. Y Tetra Tech, Inc. Q The Divitias Group QPS Hepatic Bioscience Toshiba Global Commerce Solutions Z TransCirrus Zen-Bio, Inc. Triangle ArtWorks ZumaTek, Inc. R Triangle Community Foundation Zy Therapeutics, Inc Raleigh Roots LLC Triangle Research Laboratories, LLC Research Triangle Foundation of North Carolina Triangle Ultimate Research Triangle High School Trio Labs, Inc. Reviewgo Triumfant, Inc. Ridge Diagnostics Troxler Electronic Laboratories, Inc. RTI International RTP Capital Associates, Inc. INDEX: COMPANIES, ALPHABETICAL INDEX: COMPANIES, RTP Federal Credit Union U UAI Technology, Inc. S UL LLC Schulman IRB United States Environmental Protection Agency SciKon Innovation, Inc. United States Postal Service Sciome, LLC United Therapeutics Corporation ScitoVation LLC The University of North Carolina Center for Sigma Xi, The Scientific Research Society Public Television USDA Forest Service Southern Research Station

71 5,000+ employees 100 - 249 employees Under 50 Employees Cisco Systems, Inc. Centers for Disease Control and Prevention 21st Century Creations IBM Corporation CSC Systems Aerie Pharmaceuticals, Inc. DuPont Electronics and Communications Agile EndoSurgery Ericsson AgTech Accelerator Corporation 1,000 - 4,999 employees Freudenberg IT LP (FIT) Alera Labs LLC BASF Corporation NC Families Accessing Services Alexander Business Suites Biogen Idec Through Technology All About Beer, LLC Credit Suisse Stiefel, a GSK Company American Association of Textile Fidelity Investments The University of North Carolina Center for Chemists and Colorists GlaxoSmithKline Public Television ARBIOM Lenovo Army Research Office National Institute of Environmental 50 - 99 employees Ascent Bio-Nano Technologies Health Sciences Atlantic Pharmaceuticals Ltd NetApp, Inc. AgBiome Attagene, Inc. RTI International Alion Science and Technology Corporation Avertica United States Environmental Protection Agency Copernicus Group IRB Avazyme, Inc Delta Products Corporation Avioq, Inc. ICON Clinical PLC AXA Advisors 500 - 999 employees International Society of Automation BA3 LLC. Bayer CropScience Linde Bank of America DellEMC MCNC BaseTrace Toshiba Global Commerce Solutions Medicago Benson Hill Biosystems, Inc. Monsanto Corporation BHV Pharma, Inc.

INDEX: COMPANIES BY SIZE BY INDEX: COMPANIES NC Biotechnology Center BindusChem 250 - 499 employees NC State Education Assistance Authority bioMASON BD Technologies Novozymes BioMedomics, Inc. Cree, Inc. Sigma Xi, The Scientific Research Society bioMONTR Labs Eisai, Inc. United States Postal Service BioShape Solutions FujiFilm Diosynth Biotechnologies Blackstone Entrepreneurs Network GENBAND Bluecell Energy Grifols BlocLedger Inc. Syngenta Crop Protection, LLC Bright Horizons at RTP UL LLC Bright Horizons at The Enrichment Center United Therapeutics Corporation Brite Bio, Inc. Wolfspeed, a Cree company Bunker Labs RDU Burroughs Wellcome Fund Camras Vision Start-Ups listed in TEAL Cell Microsystems Center for Innovation Management Studies The above listing is based on information provided by RTP companies and media reports. Center for International Understanding Employment range is based on the sum of full-time and contract employees. 72 Under 50 Employees, continued CertiRx Corporation Entegrion, Inc. Indexus Biomedical LLC Chaperone Therapeutics, Inc. EntreDot Intarcia Therapeutics, Inc Cell Microsystems ChemoGenics BioPharma ENVIGEN Pharmaceuticals Integrated Technical Services Centauri Surgical Systems EthosExcel Integrated Training Solutions, Inc. ChemQ Bioscience LLC Eton Bioscience Intelligaia Ciena Corporation Exam Design Inc. International Services Assistance Fund Clairvoyant Networks LLC Exinent International Union of Pure & Applied Chemistry Cealnvolt Energy Excelerate Health Ventures Inivata Inc. Clinical Ambassador Family Health Network i-xploremyhealth Clinical Sensors, Inc. Fennec Pharmaceuticals Inc. JMC (USA), Inc. Cloud Pharmaceuticals, Inc. First Citizens Bank Jobacuda LLC Cnanoz Inc First Environments Early Learning Center Kate Pope Photography Compass Datacenters First Flight Venture Center KBI Biopharma Connecture Inc. FMC Corporation Koolbridge Solar Inc Couragen Biopharmaceutics, LLC Forse, Inc. LifeNet Health CraZBrain, LLC Foundation Medicine Live Gamer CrossView, Inc. G1 Therapeutics Lucideon Creative PEGWorks Galaxy Diagnostics, Inc. Luzverde Partners Creative Scientist GEAR UP NC Market Technologies Inc. CytoFlow, LLC GENEWIZ Maverick Synfuels Curasan Inc Genetron Health Memscap, Inc. Danfoss Drives Gift Boogle MethodSense, Inc. Dharma Laboratories, LLC Gilbarco Veeder-Root Microelectronics Assembly Technologies

INDEX: COMPANIES BY SIZE BY INDEX: COMPANIES Dignify Therapeutics GlobalSubmit, Inc. Micross Components DILIsym Services Goldfinch Sensor Technolies and Analytics LLC Mispro Biotech Services DOCS GoSell Mokobio Biotechnology Group DTS Language Services, Inc. GW Pharmaceuticals Motor & Equipment Manufacturers Association EatDrinkDeals.com Heteroz, Inc. Murano Corporation ECS Federal, Inc. Hi Fidelity Genetics MyDrugCosts, Inc. Edstar Analytics, Inc. Humacyte National Computing Center EHR 2.0 iEssence Tech Inc. National Humanities Center ElectroChemical Systems, Inc. Impact Pharmaceutical Services, Inc. National Inc.lusion Project Endacea, Inc. Inanovate National Institute of Statistical Sciences National Toxicology Program NC GlaxoSmithKline Foundation NC Healthcare Information and Communications Alliance Start-Ups listed in TEAL NC New Schools NC State University MBA@RTP The above listing is based on information provided by RTP companies and media reports. Employment range is based on the sum of full-time and contract employees. 73 Under 50 Employees, continued NC State - UNC Joint Department of RTP Federal Credit Union Vijaya Pharmaceuticals LLC Biomedical Engineering Schulman IRB ViraSource NephroGenex Inc. SciKon Innovation, Inc. ViraTree Network Development Group Sciome, LLC Webonise Lab New River Investments ScitoVation LLC Wells Fargo Novocor Medical Systems SiNON Therapeutics WhiteSpace Health, Inc. NIRvana Sciences, Inc. Sirga Advanced Biopharma, Inc. XinRay Systems Inc. Novartis Vaccines Society of Biomolecular Imaging and Informatics Xintek, Inc. NovaTarg, Inc. SonoVol Xona Microfluidics, LLC NOVO, LLC Sotomayor IP Consulting, Ltd. Zen-Bio, Inc. Novocor Medical Systems Southcot, Inc. ZumaTek, Inc. Novus Energy Technologies, Inc. Spyryx Biosciences Zy Therapeutics, Inc NPBiosciences StrataBuilt Oak City Tech Strensor Systems Oerlikon Metco Symmetry Biosciences Optricity Corporation Synnovator, Inc. Orion Business Solutions LLC Synsei Medical OSSCube T3D Therapeutics Inc. Palmetto Biomedical Telemanagement Resources International Inc. Panacea Solutions TEM Systems, Inc. Park Living Cell Tetra Tech, Inc. Pharm-Olam International The Divitias Group Pine Labs TransCirrus

INDEX: COMPANIES BY SIZE BY INDEX: COMPANIES PrecisionHawk Triangle ArtWorks Premier Research Triangle Community Foundation QPS Hepatic Bioscience Triangle Research Laboratories, LLC ProteoVec, Inc. Triangle Ultimate Purple Goldfish Think Tank Trio Labs, Inc. Raleigh Roots LLC Triumfant, Inc. Research Triangle Foundation of North Carolina Troxler Electronic Laboratories, Inc. Research Triangle High School UAI Technology, Inc. Reviewgo USDA Forest Service Southern Research Station Ridge Diagnostics Vascular Pharmaceuticals, Inc RTP Capital Associates, Inc. ViiV Healthcare

Start-Ups listed in TEAL

The above listing is based on information provided by RTP companies and media reports. Employment range is based on the sum of full-time and contract employees. 74