Solid Tumor Rules 2018 Preface (Excludes Lymphoma and Leukemia M9590 – M9992)
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Who, How and What of Pathology of Soft Tissue Sarcoma
Editorial Page 1 of 11 Who, how and what of pathology of soft tissue sarcoma Salvatore Lorenzo Renne Anatomic Pathology Unit, Humanitas Research Hospital, Humanitas University, Rozzano, MI 20089, Italy Correspondence to: Salvatore Lorenzo Renne. Adjunct Teaching Professor, Anatomic Pathology Unit, Humanitas Research Hospital, Humanitas University, Via Manzoni 56, Rozzano, MI 20089, Italy. Email: [email protected]. Submitted Aug 06, 2018. Accepted for publication Aug 23, 2018. doi: 10.21037/cco.2018.10.09 View this article at: http://dx.doi.org/10.21037/cco.2018.10.09 Introduction to soft tissue sarcoma (STS) adipocytes (lipoma, spindle cells lipoma, hibernoma, well- pathology differentiated liposarcoma (LPS), myxoid LPS, etc.). One chapter is dedicated to specific entities “of uncertain STS is a generic term that refers to a heterogeneous group differentiation” that are well-characterized entities that do of rare neoplastic diseases. The aim of this review is to not readily resemble any normal mesenchymal cells (as the discuss the role of pathology in the multidisciplinary Ewing sarcoma or the synovial sarcoma—a clear misnomer). management of STS patients. This will be done: (I) The last chapter is dedicated to those sarcomas that do illustrating the framework for the current classification; (II) not follow in any of the previously listed diagnosis and are examining the characteristics that allows an expert diagnosis; therefore called “undifferentiated/unclassified sarcomas” (III) describing the role of the sarcoma pathologist -
Complete Case of a Rare but Benign Soft Tissue Tumor
Hindawi Case Reports in Orthopedics Volume 2019, Article ID 6840693, 5 pages https://doi.org/10.1155/2019/6840693 Case Report Hibernoma of the Upper Extremity: Complete Case of a Rare but Benign Soft Tissue Tumor Thomas Reichel ,1 Kilian Rueckl,1 Annabel Fenwick,1,2 Niklas Vogt,3 Maximilian Rudert,1 and Piet Plumhoff1 1Department of Orthopedic Surgery, Koenig-Ludwig-Haus, University of Wuerzburg, Brettreichstraße 11, 97074 Wuerzburg, Germany 2Department of Trauma Surgery, Klinikum Augsburg, 86156 Augsburg, Germany 3Department of Pathology, University of Wuerzburg, 97080 Wuerzburg, Germany Correspondence should be addressed to Thomas Reichel; [email protected] Received 26 February 2019; Accepted 14 April 2019; Published 21 May 2019 Academic Editor: Elke R. Ahlmann Copyright © 2019 Thomas Reichel et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Hibernoma is a rare benign lipomatous tumor showing differentiation of brown fatty tissue. To the author’s best knowledge, there is no known case of malignant transformation or metastasis. Due to their slow, noninfiltrating growth hibernomas are often an incidental finding in the third or fourth decade of life. The vast majority are located in the thigh, neck, and periscapular region. A diagnostic workup includes ultrasound and contrast-enhanced MRI. Differential diagnosis is benign lipoma, well- differentiated liposarcoma, and rhabdomyoma. An incisional biopsy followed by marginal resection of the tumor is the standard of care, and recurrence after complete resection is not reported. The current paper presents diagnostic and intraoperative findings of a hibernoma of the upper arm and reviews similar reports in the current literature. -
Circuition: Concerto for Jazz Guitar and Orchestra
University of Kentucky UKnowledge Theses and Dissertations--Music Music 2021 CIRCUITION: CONCERTO FOR JAZZ GUITAR AND ORCHESTRA Richard Alan Robinson University of Kentucky, [email protected] Digital Object Identifier: https://doi.org/10.13023/etd.2021.166 Right click to open a feedback form in a new tab to let us know how this document benefits ou.y Recommended Citation Robinson, Richard Alan, "CIRCUITION: CONCERTO FOR JAZZ GUITAR AND ORCHESTRA" (2021). Theses and Dissertations--Music. 178. https://uknowledge.uky.edu/music_etds/178 This Doctoral Dissertation is brought to you for free and open access by the Music at UKnowledge. It has been accepted for inclusion in Theses and Dissertations--Music by an authorized administrator of UKnowledge. For more information, please contact [email protected]. STUDENT AGREEMENT: I represent that my thesis or dissertation and abstract are my original work. Proper attribution has been given to all outside sources. I understand that I am solely responsible for obtaining any needed copyright permissions. I have obtained needed written permission statement(s) from the owner(s) of each third-party copyrighted matter to be included in my work, allowing electronic distribution (if such use is not permitted by the fair use doctrine) which will be submitted to UKnowledge as Additional File. I hereby grant to The University of Kentucky and its agents the irrevocable, non-exclusive, and royalty-free license to archive and make accessible my work in whole or in part in all forms of media, now or hereafter known. I agree that the document mentioned above may be made available immediately for worldwide access unless an embargo applies. -
Orbital Involvement with Desmoplastic Melanoma*
Br J Ophthalmol: first published as 10.1136/bjo.71.4.279 on 1 April 1987. Downloaded from British Journal of Ophthalmology, 1987, 71, 279-284 Orbital involvement with desmoplastic melanoma* JERRY A SHIELDS,'4 DAVID ELDER,2 VIOLETTA ARBIZO,4 THOMAS HEDGES,' AND JAMES J AUGSBURGER' From the 'Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, the 'Pigmented Lesion Group, Department of Dermatology and of Pathology and Laboratory Medicine, University of Pennsylvawa, the 'Department of Ophthalmology, Pennsylvania Hospital, and the 4Pathology Department, Wills Eye Hospital, USA. SUMMARY A 79-year-old woman developed an orbital mass five and a half years after excision of a cutaneous melanoma from the side of the nose. The initial orbital biopsy was interpreted histopathologically as a malignant fibrous histiocytoma, but special stains and electron microscopy showed it to be a desmoplastic malignant melanoma which had apparently spread to the orbit from the prioriskin lesion by neurotropic mechanisms. The occurrence of a desmoplastic neurotropic melanoma in the orbit has not been previously recognised. The problems in the clinical and pathological diagnosis of this rare type of melanoma are discussed. Orbital involvement with malignant melanoma most August 1984 she had excision of scar tissue around often occurs secondary to extrascleral extension the left eye and biopsy of a 'cyst' in the left upper of posteribr uveal melanoma.' Primary orbital eyelid, which was diagnosed at another hospital as a melanoma and metastatic cutaneous melanoma malignant fibrous histiocytoma. http://bjo.bmj.com/ to the orbit are extremely rare.2 Desmoplastic A general physical examination gave essentially melanoma is a rare form of cutaneous melanoma normal results, and complete examination of the which can extend from a superficial location into the right eye revealed no abnormalities. -
Analytic, Descriptive, and Prescriptive Components of Evolving Jazz: a New Model Based on the Works of Brad Mehldau
Analytic, Descriptive, and Prescriptive Components of Evolving Jazz: A New Model Based on the Works of Brad Mehldau Mark Edward Baynes An exegesis submitted in partial fulfilment of the requirements for the degree of Doctor of Musical Arts The University of Auckland 2015 ii Abstract Jazz has steadily evolved from its inception in the late 19th century to the present. As is the case for other genres, musicological analytic research on jazz evolution has lagged behind its practice; consequently, there is a paucity of in-depth descriptive and analytic research on the music of recent innovators. Among the most recent examples of this evolution, the works of Brad Mehldau as a solo/ensemble pianist and as a composer arguably embody some of the most compelling innovations in the field. Non-academically oriented jazz writers and fans have consistently assigned these works vanguard status, but Mehldau’s output has not yet been sufficiently examined to prescribe performance methods. This exegesis contains (1) descriptive analysis of improvisation contained within a broad cross-section of Mehldau’s music; (2) definition of a new analytical lexicon derived from a holistic study of consonance, dissonance, and research into perceived motivation in music; and (3) prescriptive musical tools relating to consonance and dissonance that have informed the researcher’s performance. iii Acknowledgements I would like to express my special thanks to Dr David Lines, Associate Professor W. Dean Sutcliffe, Dr Davinia Caddy, Kevin Field, Dr Mark Kramer, Gary Burton, Jo Shum, Steve Harvie, Alex Freer, Tom Dennison, Dixon Nacey, Nick Marsh, Jason Orme, Chrissie Hart, Hadyn Godfrey, Chris Mason-Battley, Phil Broadhurst, Kim Paterson, Tom Rainey, Mike Booth and Stephen Morton-Jones. -
Acral Compound Nevus SJ Yun S Korea
University of Pennsylvania, Founded by Ben Franklin in 1740 Disclosures Consultant for Myriad Genetics and for SciBase (might try to sell you a book, as well) Multidimensional Pathway Classification of Melanocytic Tumors WHO 4th Edition, 2018 Epidemiologic, Clinical, Histologic and Genomic Aspects of Melanoma David E. Elder, MB ChB, FRCPA University of Pennsylvania, Philadelphia, PA, USA Napa, May, 2018 3rd Edition, 2006 Malignant Melanoma • A malignant tumor of melanocytes • Not all melanomas are the same – variation in: – Epidemiology – risk factors, populations – Cell/Site of origin – Precursors – Clinical morphology – Microscopic morphology – Simulants – Genomic abnormalities Incidence of Melanoma D.M. Parkin et al. CSD/Site-Related Classification • Bastian’s CSD/Site-Related Classification (Taxonomy) of Melanoma – “The guiding principles for distinguishing taxa are genetic alterations that arise early during progression; clinical or histologic features of the primary tumor; characteristics of the host, such as age of onset, ethnicity, and skin type; and the role of environmental factors such as UV radiation.” Bastian 2015 Epithelium associated Site High UV Low UV Glabrous Mucosa Benign Acquired Spitz nevus nevus Atypical Dysplastic Spitz Borderline nevus tumor High Desmopl. Low-CSD Spitzoid Acral Mucosal Malignant CSD melanoma melanoma melanoma melanoma melanoma 105 Point mutations 103 Structural Rearrangements 2018 WHO Classification of Melanoma • Integrates Epidemiologic, Genomic, Clinical and Histopathologic Features • Assists -
A Case of Intradermal Melanocytic Nevus with Ossification (Nevus of Nanta)
197 A Case of Intradermal Melanocytic Nevus with Ossification (Nevus of Nanta) Young Bok Lee, M.D., Kyung Ho Lee, M.D., Chul Jong Park, M.D. Department of Dermatology, College of Medicine, The Catholic University of Korea, Seoul, Korea A 49-year-old woman presented with a 30-year history of asymptomatic plaque on her right temple. The histological examination revealed nests of nevus cells throughout the entire dermis. Bony spicules were seen just beneath the nevus cell nests in the lower dermis. Cutaneous ossification is an unusual event. Herein, we present a case of intradermal melanocytic nevus with unusual ossification (nevus of Nanta). To the best of our knowledge, this is the first such case report in the Korean literature. (Ann Dermatol (Seoul) 20(4) 197∼199, 2008) Key Words: Melanocytic nevus, Ossification INTRODUCTION drug intake or medical illness. The histological examination showed a dense proliferation of benign Ossification within the skin may occur in a nevus cells in the upper dermis. They were arranged variety of conditions, including pilomatricoma, basal in nests surrounding the hair follicles (Fig. 2). Bony cell carcinoma, appendageal and fibrous prolifera- spicules were seen in the lower dermis, underneath 1,2 tion, inflammation and trauma . The occurrence of the nevus cell nests. Some of them were compact ossification within a melanocytic nevus is an un- while others were surrounded by mature fatty tissue 3-5 usual event . (Fig. 3). Herein, we present a case of intradermal melano- cytic nevus with unusual ossification (nevus of Nanta). To the best our knowledge, this is the first such case report in the Korean literature. -
PROPOSED REGULATION of the STATE BOARD of HEALTH LCB File No. R057-16
PROPOSED REGULATION OF THE STATE BOARD OF HEALTH LCB File No. R057-16 Section 1. Chapter 457 of NAC is hereby amended by adding thereto the following provision: 1. The Division may impose an administrative penalty of $5,000 against any person or organization who is responsible for reporting information on cancer who violates the provisions of NRS 457. 230 and 457.250. 2. The Division shall give notice in the manner set forth in NAC 439.345 before imposing any administrative penalty 3. Any person or organization upon whom the Division imposes an administrative penalty pursuant to this section may appeal the action pursuant to the procedures set forth in NAC 439.300 to 439. 395, inclusive. Section 2. NAC 457.010 is here by amended to read as follows: As used in NAC 457.010 to 457.150, inclusive, unless the context otherwise requires: 1. “Cancer” has the meaning ascribed to it in NRS 457.020. 2. “Division” means the Division of Public and Behavioral Health of the Department of Health and Human Services. 3. “Health care facility” has the meaning ascribed to it in NRS 457.020. 4. “[Malignant neoplasm” means a virulent or potentially virulent tumor, regardless of the tissue of origin. [4] “Medical laboratory” has the meaning ascribed to it in NRS 652.060. 5. “Neoplasm” means a virulent or potentially virulent tumor, regardless of the tissue of origin. 6. “[Physician] Provider of health care” means a [physician] provider of health care licensed pursuant to chapter [630 or 633] 629.031 of NRS. 7. “Registry” means the office in which the Chief Medical Officer conducts the program for reporting information on cancer and maintains records containing that information. -
Discover Seventh Chords
Seventh Chords Stack of Thirds - Begin with a major or natural minor scale (use raised leading tone for chords based on ^5 and ^7) - Build a four note stack of thirds on each note within the given key - Identify the characteristic intervals of each of the seventh chords w w w w w w w w % w w w w w w w Mw/M7 mw/m7 m/m7 M/M7 M/m7 m/m7 d/m7 w w w w w w % w w w w #w w #w mw/m7 d/wm7 Mw/M7 m/m7 M/m7 M/M7 d/d7 Seventh Chord Quality - Five common seventh chord types in diatonic music: * Major: Major Triad - Major 7th (M3 - m3 - M3) * Dominant: Major Triad - minor 7th (M3 - m3 - m3) * Minor: minor triad - minor 7th (m3 - M3 - m3) * Half-Diminished: diminished triad - minor 3rd (m3 - m3 - M3) * Diminished: diminished triad - diminished 7th (m3 - m3 - m3) - In the Major Scale (all major scales!) * Major 7th on scale degrees 1 & 4 * Minor 7th on scale degrees 2, 3, 6 * Dominant 7th on scale degree 5 * Half-Diminished 7th on scale degree 7 - In the Minor Scale (all minor scales!) with a raised leading tone for chords on ^5 and ^7 * Major 7th on scale degrees 3 & 6 * Minor 7th on scale degrees 1 & 4 * Dominant 7th on scale degree 5 * Half-Diminished 7th on scale degree 2 * Diminished 7th on scale degree 7 Using Roman Numerals for Triads - Roman Numeral labels allow us to identify any seventh chord within a given key. -
Music in Theory and Practice
CHAPTER 4 Chords Harmony Primary Triads Roman Numerals TOPICS Chord Triad Position Simple Position Triad Root Position Third Inversion Tertian First Inversion Realization Root Second Inversion Macro Analysis Major Triad Seventh Chords Circle Progression Minor Triad Organum Leading-Tone Progression Diminished Triad Figured Bass Lead Sheet or Fake Sheet Augmented Triad IMPORTANT In the previous chapter, pairs of pitches were assigned specifi c names for identifi cation CONCEPTS purposes. The phenomenon of tones sounding simultaneously frequently includes group- ings of three, four, or more pitches. As with intervals, identifi cation names are assigned to larger tone groupings with specifi c symbols. Harmony is the musical result of tones sounding together. Whereas melody implies the Harmony linear or horizontal aspect of music, harmony refers to the vertical dimension of music. A chord is a harmonic unit with at least three different tones sounding simultaneously. Chord The term includes all possible such sonorities. Figure 4.1 #w w w w w bw & w w w bww w ww w w w w w w w‹ Strictly speaking, a triad is any three-tone chord. However, since western European music Triad of the seventeenth through the nineteenth centuries is tertian (chords containing a super- position of harmonic thirds), the term has come to be limited to a three-note chord built in superposed thirds. The term root refers to the note on which a triad is built. “C major triad” refers to a major Triad Root triad whose root is C. The root is the pitch from which a triad is generated. 73 3711_ben01877_Ch04pp73-94.indd 73 4/10/08 3:58:19 PM Four types of triads are in common use. -
Melanocytic Lesions of the Face—SW Mccarthy & RA Scolyer 3 Review Article
Melanocytic Lesions of the Face—SW McCarthy & RA Scolyer 3 Review Article Melanocytic Lesions of the Face: Diagnostic Pitfalls* 1,2 1,2 SW McCarthy, MBBS, FRCPA, RA Scolyer, MBBS, FRCPA Abstract The pathologist often has a difficult task in evaluating melanocytic lesions. For lesions involving the face the consequences of misdiagnosis are compounded for both cosmetic and therapeutic reasons. In this article, the pathological features of common and uncommon benign and malignant melanocytic lesions are reviewed and pitfalls in their diagnosis are highlighted. Benign lesions resembling melanomas include regenerating naevus, “irritated” naevus, com- bined naevus, “ancient naevus”, Spitz naevus, dysplastic naevus, halo naevus, variants of blue naevi, balloon and clear cell naevi, neurotised naevus and desmoplastic naevus. Melanomas that can easily be missed on presentation include desmoplastic, naevoid, regressed, myxoid and metastatic types as well as so-called malignant blue naevi. Pathological clues to benign lesions include good symmetry, V-shaped silhouette, absent epidermal invasion, uniform cellularity, deep maturation, absent or rare dermal mitoses and clustered Kamino bodies. Features more commonly present in melanomas include asymmetry, peripheral epidermal invasion, heavy or “dusty” pigmentation, deep and abnormal dermal mitoses, HMB45 positivity in deep dermal melanocytes, vascular invasion, neurotropism and satellites. Familiarity with the spectrum of melanocytic lesions and knowledge of the important distinguishing features should -
Variants of Acinar Adenocarcinoma of the Prostate Mimicking Benign Conditions Peter a Humphrey
Modern Pathology (2018) 31, S64–S70 S64 © 2018 USCAP, Inc All rights reserved 0893-3952/18 $32.00 Variants of acinar adenocarcinoma of the prostate mimicking benign conditions Peter A Humphrey Department of Pathology, Yale School of Medicine, New Haven, CT, USA Histological variants of acinar adenocarcinoma of the prostate may be of significance due to difficulty in diagnosis or due to differences in prognosis compared to usual acinar adenocarcinoma. The 2016 World Health Organization classification of acinar adenocarcinoma includes four variants that are deceptively benign in histological appearance, such that a misdiagnosis of a benign condition may be made. These four variants are atrophic pattern adenocarcinoma, pseudohyperplastic adenocarcinoma, microcystic adenocarcinoma, and foamy gland adenocarcinoma. They differ from usual small acinar adenocarcinoma in architectural glandular structure and/or cytoplasmic and nuclear alterations. The variants are often admixed, in variable proportions, with usual small acinar adenocarcinoma that is often Gleason pattern 3 but may be high-grade pattern 4 in a minority of cases. Atrophic pattern adenocarcinoma can be identified in a sporadic setting or after radiation or hormonal therapy. This variant is characterized by cytoplasmic volume loss and can resemble benign glandular atrophy, an extremely common benign process in the prostate. The glands of pseudohyperplastic adenocarcinoma simulate usual epithelial hyperplasia, with gland complexity that is not typical of small acinar adenocarcinoma. These complex growth configurations include papillary infoldings, luminal undulations, and branching. Microcystic adenocarcinoma is characterized by cystic dilation of prostatic glands to a size that is much more commonly observed in cystic change in benign prostatic glands. Finally, the cells in foamy gland adenocarcinoma display cytoplasmic vacuolization and nuclear pyknosis, features that can found in benign glands and macrophages.